#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q80YA9	uniprotkb:P83510	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	-	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q921J2	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-7924728|intact:MINT-4611176|ensembl:ENSMUSP00000030787	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:rheb_mouse(display_long)|uniprotkb:Rheb(gene name)|psi-mi:Rheb(display_short)|uniprotkb:Ras homolog enriched in brain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_444305.2|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2000074"(regulation of type B pancreatic cell development)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR037586|mint:Q921J2|rcsb pdb:4O25|rcsb pdb:4O2L|rcsb pdb:4O2R|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8943724|reactome:R-MMU-9639288|ensembl:ENSMUSG00000028945(gene)|ensembl:ENSMUST00000030787(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)	-	-	function:Not known; binds GTP and exhibits intrinsic GTPase activity|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:hWQL1uMB4w4vwGD6IZBHfOx9UaI10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q8VDG3	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-8402250|intact:MINT-4106622|uniprotkb:Q8C7N6|uniprotkb:Q9DC46	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:parn_mouse(display_long)|uniprotkb:Parn(gene name)|psi-mi:Parn(display_short)|uniprotkb:Polyadenylate-specific ribonuclease(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_083037.1|dip:DIP-48330N|mint:Q8VDG3|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003723"(RNA binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0043169"(cation binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0071051"(polyadenylation-dependent snoRNA 3'-end processing)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:0110008"(ncRNA deadenylation)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR014789("Poly(A)-specific ribonuclease, RNA binding")|interpro:IPR034042|interpro:IPR035979|interpro:IPR036397|interpro:IPR036867|rcsb pdb:1UG8|rcsb pdb:1WHV|rcsb pdb:2ROK|rcsb pdb:3D45|reactome:R-MMU-429947|reactome:R-MMU-450604	-	-	comment:mint|function:"3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:X82UAPZBe5zWu+3h3nFrZocZQFs10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P63101	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P39447	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-79508|uniprotkb:E9QK00|ensembl:ENSMUSP00000099652	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:zo1_mouse(display_long)|uniprotkb:Tjp1(gene name)|psi-mi:Tjp1(display_short)|uniprotkb:Zo1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005516"(calmodulin binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0005634"(nucleus)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0005737"(cytoplasm)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0005921"(gap junction)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045471"(response to ethanol)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0071000"(response to magnetism)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0071253"(connexin binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:0014704"(intercalated disc)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:0016020"(membrane)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035597|interpro:IPR036028|interpro:IPR036034|mint:P39447|rcsb pdb:2RRM|reactome:R-MMU-191650|reactome:R-MMU-2028269|reactome:R-MMU-351906|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|ensembl:ENSMUSG00000030516(gene)|ensembl:ENSMUST00000102592(transcript)|go:"GO:0001825"(blastocyst formation)|refseq:NP_033412.2|dip:DIP-30946N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:wvslyL15GCrtwUReZEC9DiNvPEk10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:F6SEU4	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-5797569|ensembl:ENSMUSP00000141686	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q61548	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-775174|uniprotkb:Q61547|uniprotkb:Q8K0D4	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:ap180_mouse(display_long)|uniprotkb:Clathrin coat-associated protein AP180(gene name synonym)|uniprotkb:91 kDa synaptosomal-associated protein(gene name synonym)|uniprotkb:Phosphoprotein F1-20(gene name synonym)|uniprotkb:Snap91(gene name)|psi-mi:Snap91(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001264911.1|refseq:NP_001264915.1|refseq:NP_038697.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|refseq:XP_006510957.1|refseq:XP_006510963.1|interpro:IPR030428|mint:Q61548|go:"GO:0000149"(SNARE binding)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043679"(axon terminus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1904006"(negative regulation of phospholipase D activity)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:uew/lk0YJ8j0CQULEZaC/qLlLF810090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q4ACU6	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q80TE7	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-774900	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:lrrc7_mouse(display_long)|uniprotkb:Protein LAP1(gene name synonym)|uniprotkb:Densin-180(gene name synonym)|uniprotkb:Lrrc7(gene name)|psi-mi:Lrrc7(display_short)|uniprotkb:Kiaa1365(gene name synonym)|uniprotkb:Lap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001278381.1|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR032675|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR036034|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6798695|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043194"(axon initial segment)|go:"GO:0043197"(dendritic spine)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:QWCdfe/eQM/ZaaAG2GwZi+Rf87Q10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q9D415	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q62108	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q91XM9	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-400138|uniprotkb:Q8BXK7|uniprotkb:Q8BYG5|ensembl:ENSMUSP00000102814|uniprotkb:F8VQM7	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:dlg2_mouse(display_long)|uniprotkb:Dlg2(gene name)|psi-mi:Dlg2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	ensembl:ENSMUSG00000052572(gene)|ensembl:ENSMUST00000107196(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035759|interpro:IPR036028|interpro:IPR036034|mint:Q91XM9|rcsb pdb:2WL7|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6794361|refseq:NP_001229976.1|refseq:NP_035937.2|dip:DIP-31569N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:37/IFbjDNxh87dnN2gglIgDGyIU10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q811D0	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-514290|uniprotkb:Q62402|uniprotkb:Q6PGB5|uniprotkb:Q8CGN7|ensembl:ENSMUSP00000097581|ensembl:ENSMUSP00000110859	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:dlg1_mouse(display_long)|uniprotkb:Synapse-associated protein 97(gene name synonym)|uniprotkb:Embryo-dlg/synapse-associated protein 97(gene name synonym)|uniprotkb:Dlg1(gene name)|psi-mi:Dlg1(display_short)|uniprotkb:Dlgh1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_031888.2|refseq:NP_001239362.1|refseq:NP_001239364.1|refseq:XP_006521831.1|refseq:NP_001239363.1|dip:DIP-31591N|ensembl:ENSMUSG00000022770(gene)|ensembl:ENSMUST00000100001(transcript)|ensembl:ENSMUST00000115205(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034629"|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043219"(lateral loop)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060022"(hard palate development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1902473"(regulation of protein localization to synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903286"(regulation of potassium ion import)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903760"(regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:1903764"(regulation of potassium ion export across plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR015143(L27-1)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q811D0|rcsb pdb:4OAJ|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-8849932	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:b8LjYbiuR2K6/jxhwU1hxBJKX6410090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q8BKX1	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q3UHD9	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-771911|uniprotkb:Q5DU45|ensembl:ENSMUSP00000043466	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:agap2_mouse(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Kiaa0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001028435.1|refseq:NP_001287943.1|ensembl:ENSMUSG00000025422(gene)|ensembl:ENSMUST00000039259(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|go:"GO:0005768"(endosome)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:yq2lQtfk+FPqgT++CxAx2CS69nE10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q8BYI9	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-774167|uniprotkb:A2RT70|uniprotkb:O88717|ensembl:ENSMUSP00000107298|ensembl:ENSMUSP00000141553	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:tenr_mouse(display_long)|uniprotkb:Restrictin(gene name synonym)|uniprotkb:Janusin(gene name synonym)|uniprotkb:Neural recognition molecule J1-160/180(gene name synonym)|uniprotkb:Tnr(gene name)|psi-mi:Tnr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_071707.2|refseq:XP_006496805.1|refseq:XP_006496806.1|refseq:XP_006496807.1|ensembl:ENSMUSG00000015829(gene)|ensembl:ENSMUST00000111669(transcript)|ensembl:ENSMUST00000192069(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0045121"(membrane raft)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048692"(negative regulation of axon extension involved in regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072534"(perineuronal net)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098966"(perisynaptic extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR033079|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:Q8BYI9|reactome:R-MMU-3000178	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:K7s7yPGS4RvIe+thCkAZIFGjNRA10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P46096	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-445340|ensembl:ENSMUSP00000063293|ensembl:ENSMUSP00000100912	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:syt1_mouse(display_long)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym)|uniprotkb:Syt1(gene name)|psi-mi:Syt1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001239271.1|refseq:NP_033332.1|refseq:XP_006513509.1|refseq:XP_006513510.1|refseq:XP_006513511.1|refseq:NP_001239270.1|ensembl:ENSMUSG00000035864(gene)|ensembl:ENSMUST00000064054(transcript)|ensembl:ENSMUST00000105276(transcript)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051291"(protein heterooligomerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0000149"(SNARE binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|refseq:XP_017169355.1|go:"GO:0060076"(excitatory synapse)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071911"(synchronous neurotransmitter secretion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098746"(fast, calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903235"(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903305"(regulation of regulated secretory pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|mint:P46096|rcsb pdb:5T0R|rcsb pdb:5T0S|rcsb pdb:5VFE|rcsb pdb:5VFF|rcsb pdb:5VFG|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-888590|dip:DIP-31322N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:CxQGrKu3l0pEzQ3aJZBJ/GZMyEA10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q68FG2	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-2255511|ensembl:ENSMUSP00000008991	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:q68fg2_mouse(display_long)|uniprotkb:Sptbn2(gene name)|psi-mi:Sptbn2(display_short)|uniprotkb:Spnb3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_067262.1|refseq:XP_006531767.1|refseq:XP_006531768.1|ensembl:ENSMUSG00000067889(gene)|ensembl:ENSMUST00000008991(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008091"(spectrin)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0030534"(adult behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051693"(actin filament capping)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098918"(structural constituent of synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:0099189"(postsynaptic spectrin-associated cytoskeleton)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-MMU-2132295|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:2F7U0dl21KxXpc9Z2sk7D/wzQvM10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q62261	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P16546	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-911063|uniprotkb:A3KGU6|uniprotkb:Q8K380|uniprotkb:Q9CT05|uniprotkb:A3KGU8|ensembl:ENSMUSP00000092697	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:sptn1_mouse(display_long)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym)|uniprotkb:Spta2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	dip:DIP-37712N|ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000095083(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032437"(cuticular plate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:P16546|reactome:R-MMU-264870|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:UVB6Kv+PBlqDH3OLoGjxm5oYVPQ10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P63318	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-397096|uniprotkb:P05697|ensembl:ENSMUSP00000097874	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:kpcg_mouse(display_long)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_035232.1|ensembl:ENSMUSG00000078816(gene)|ensembl:ENSMUST00000100301(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0005829"(cytosol)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|interpro:IPR020454|interpro:IPR035892|mint:P63318|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-416993|reactome:R-MMU-5099900|reactome:R-MMU-76005	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P68181	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-400685|uniprotkb:P05206|uniprotkb:Q3TQH5|uniprotkb:Q3UDD0|uniprotkb:Q3UTH5|ensembl:ENSMUSP00000099573	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:kapcb_mouse(display_long)|uniprotkb:Prkacb(gene name)|psi-mi:Prkacb(display_short)|uniprotkb:Pkacb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001157670.1|refseq:NP_001157671.1|refseq:NP_001157672.1|refseq:NP_035230.1|ensembl:ENSMUSG00000005034(gene)|ensembl:ENSMUST00000102515(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0097338"(response to clozapine)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044109|mint:P68181|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356|reactome:R-MMU-432040|reactome:R-MMU-4420097|reactome:R-MMU-442720|reactome:R-MMU-5610785|reactome:R-MMU-5610787|reactome:R-MMU-5621575|reactome:R-MMU-5687128|reactome:R-MMU-8853659|reactome:R-MMU-8963896|reactome:R-MMU-983231	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:9278c8xZsjU90+vryXpzUc0y/G010090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P09411	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-1634776|uniprotkb:Q3TPE6|uniprotkb:Q3UKV8|uniprotkb:Q5XJE7|ensembl:ENSMUSP00000080302	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:pgk1_mouse(display_long)|uniprotkb:Pgk1(gene name)|psi-mi:Pgk1(display_short)|uniprotkb:Pgk-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_032854.2|dip:DIP-51710N|ensembl:ENSMUSG00000062070(gene)|ensembl:ENSMUST00000081593(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0016310"(phosphorylation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031639"(plasminogen activation)|go:"GO:0043531"(ADP binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047134"("protein-disulfide reductase (NAD(P)) activity")|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|mint:P09411|rcsb pdb:4O3F|reactome:R-MMU-70171|reactome:R-MMU-70263	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:388hPtU1n0xYbopG53ZWslYTzuk10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q99LX0	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-1634273|uniprotkb:O88306|uniprotkb:Q3THB9|uniprotkb:Q3U509|ensembl:ENSMUSP00000030805|ensembl:ENSMUSP00000101298|ensembl:ENSMUSP00000101299|ensembl:ENSMUSP00000101300	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:park7_mouse(display_long)|uniprotkb:Park7(gene name)|psi-mi:Park7(display_short)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_065594.2|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|mint:Q99LX0|reactome:R-MMU-3899300|reactome:R-MMU-9646399|ensembl:ENSMUSG00000028964(gene)|ensembl:ENSMUST00000030805(transcript)|ensembl:ENSMUST00000105673(transcript)|ensembl:ENSMUST00000105674(transcript)|ensembl:ENSMUST00000105675(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007338"(single fertilization)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0061827"(sperm head)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:dfkL4WeM+WgrYJa3aYTWbFyi0bk10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P08551	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-445199|uniprotkb:Q8K0Z0|ensembl:ENSMUSP00000022639	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:nfl_mouse(display_long)|uniprotkb:Neurofilament triplet L protein(gene name synonym)|uniprotkb:68 kDa neurofilament protein(gene name synonym)|uniprotkb:Nefl(gene name)|psi-mi:Nefl(display_short)|uniprotkb:Nfl(gene name synonym)|uniprotkb:Nf68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_035040.1|ensembl:ENSMUSG00000022055(gene)|ensembl:ENSMUST00000022639(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027692|interpro:IPR039008|mint:P08551|reactome:R-MMU-438066|reactome:R-MMU-5673001|go:"GO:0098981"(cholinergic synapse)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0040011"(locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051258"(protein polymerization)|go:"GO:0051412"(response to corticosterone)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060074"(synapse maturation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|dip:DIP-31944N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:E8KK2ppZXyLXIlFZp/pjXv7GBEU10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q9JM52	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-645434|uniprotkb:Q5SXG2|uniprotkb:Q921M6|uniprotkb:Q9JM92|ensembl:ENSMUSP00000099619	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:mink1_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase kinase kinase kinase 6(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 6(gene name synonym)|uniprotkb:Misshapen/NIK-related kinase(gene name synonym)|uniprotkb:GCK family kinase MiNK(gene name synonym)|uniprotkb:Mink1(gene name)|psi-mi:Mink1(display_short)|uniprotkb:Map4k6(gene name synonym)|uniprotkb:Mink(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_795712.2|refseq:XP_006533744.1|refseq:NP_057922.2|ensembl:ENSMUSG00000020827(gene)|ensembl:ENSMUST00000102559(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007275"(multicellular organism development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000311"(regulation of AMPA receptor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9JM52|reactome:R-MMU-2559580	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:Kuk8yQcHbIShH9SwsEkvyMTVcMw10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q52KR2	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-16727039|ensembl:ENSMUSP00000035999|uniprotkb:Q69ZY8	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:lrig2_mouse(display_long)|uniprotkb:Lrig2(gene name)|psi-mi:Lrig2(display_short)|uniprotkb:Kiaa0806(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	ensembl:ENSMUSG00000032913(gene)|ensembl:ENSMUST00000046316(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010640"(regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031012"(extracellular matrix)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0060384"(innervation)|go:"GO:0097708"(intracellular vesicle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|go:"GO:0016020"(membrane)|refseq:NP_001020238.1|refseq:NP_001297627.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:FOQEaeILqHCNXZ8Oqz2inZZ0c2w10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q8R0S2	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-772277|uniprotkb:Q3TZC3|uniprotkb:Q5DU15|ensembl:ENSMUSP00000098712	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:iqec1_mouse(display_long)|uniprotkb:Iqsec1(gene name)|psi-mi:Iqsec1(display_short)|uniprotkb:Kiaa0763(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001127855.1|ensembl:ENSMUSG00000034312(gene)|ensembl:ENSMUST00000101153(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR030737|interpro:IPR033742|interpro:IPR035999	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:BZg7CaLndE4ak8KXs34YFf9iBRQ10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P46660	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-400482|uniprotkb:Q61958|uniprotkb:Q8VCW5|ensembl:ENSMUSP00000041347	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:ainx_mouse(display_long)|uniprotkb:Ina(gene name)|psi-mi:Ina(display_short)|uniprotkb:66 kDa neurofilament protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_666212.3|ensembl:ENSMUSG00000034336(gene)|ensembl:ENSMUST00000037636(transcript)|go:"GO:0005883"(neurofilament)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027703|interpro:IPR039008|mint:P46660	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:amjP0AajB8s2oXmV96wzyfz6evE10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q68EF4	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-15809151|uniprotkb:Q80UC2	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:grm4_mouse(display_long)|uniprotkb:Grm4(gene name)|psi-mi:Grm4(display_short)|uniprotkb:Gprc1d(gene name synonym)|uniprotkb:Mglur4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001786(GPCR, family 3, metabotropic glutamate receptor 4)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048787"(presynaptic active zone membrane)|reactome:R-MMU-418594|reactome:R-MMU-420499|refseq:NP_001013403.1|dip:DIP-49002N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:YyzCS0VeGoh92zPBZEKAQdul7Kw10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P62874	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-357152|ensembl:ENSMUSP00000030940|ensembl:ENSMUSP00000101241|ensembl:ENSMUSP00000130123|ensembl:ENSMUSP00000135091|uniprotkb:P04901|uniprotkb:P04697	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:gbb1_mouse(display_long)|uniprotkb:Gnb1(gene name)|psi-mi:Gnb1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	ensembl:ENSMUSG00000029064(gene)|ensembl:ENSMUST00000030940(transcript)|ensembl:ENSMUST00000105616(transcript)|ensembl:ENSMUST00000165335(transcript)|ensembl:ENSMUST00000176637(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007603"(phototransduction, visible light)|reactome:R-MMU-9009391|reactome:R-MMU-997272|reactome:R-MMU-8964616|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030425"(dendrite)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043209"(myelin sheath)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62874|rcsb pdb:6K41|rcsb pdb:6K42|rcsb pdb:6RMV|reactome:R-MMU-1296041|reactome:R-MMU-202040|reactome:R-MMU-2485179|reactome:R-MMU-381676|reactome:R-MMU-381753|reactome:R-MMU-392170|reactome:R-MMU-392451|reactome:R-MMU-392851|reactome:R-MMU-400042|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418217|reactome:R-MMU-418555|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418597|reactome:R-MMU-420092|reactome:R-MMU-428930|reactome:R-MMU-432040|reactome:R-MMU-456926|reactome:R-MMU-500657|reactome:R-MMU-6814122|reactome:R-MMU-8964315|refseq:NP_001153488.1|refseq:NP_001153489.1|refseq:NP_032168.1|refseq:XP_017175466.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:zP/G70MXiSQpzbyyWFTWrJFQENk10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P18872	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-771950|uniprotkb:P18873|intact:EBI-1018769|ensembl:ENSMUSP00000034198|ensembl:ENSMUSP00000114144	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:gnao_mouse(display_long)|uniprotkb:Gnao1(gene name)|psi-mi:Gnao1(display_short)|uniprotkb:Gna0(gene name synonym)|uniprotkb:Gnao(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001106855.1|refseq:NP_034438.1|dip:DIP-29921N|ensembl:ENSMUSG00000031748(gene)|ensembl:ENSMUST00000034198(transcript)|ensembl:ENSMUST00000125716(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009987"(cellular process)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P18872|rcsb pdb:3C7K|reactome:R-MMU-4086398	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:CCww9l5owYxGicswRXjsSu6Y+5g10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P15105	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-444858|uniprotkb:Q3TRK7|uniprotkb:Q64432|uniprotkb:Q91VC6|ensembl:ENSMUSP00000083375|ensembl:ENSMUSP00000123157	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:glna_mouse(display_long)|uniprotkb:Glutamate--ammonia ligase(gene name synonym)|uniprotkb:Glul(gene name)|psi-mi:Glul(display_short)|uniprotkb:Glns(gene name synonym)|uniprotkb:Palmitoyltransferase GLUL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_032157.2|go:"GO:0030145"(manganese ion binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0097386"(glial cell projection)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR008146(Glutamine synthetase, catalytic region)|interpro:IPR008147(Glutamine synthetase, beta-Grasp)|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR027302|interpro:IPR027303|interpro:IPR036651|mint:P15105|reactome:R-MMU-210455|reactome:R-MMU-8964539|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|ensembl:ENSMUSG00000026473(gene)|ensembl:ENSMUST00000086199(transcript)|ensembl:ENSMUST00000140685(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0004356"(glutamate-ammonia ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006542"(glutamine biosynthetic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0016595"(glutamate binding)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019676"(ammonia assimilation cycle)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:j6R9fxGLKpiREWpecpdnBY9ftoo10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q68FF6	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-645933|ensembl:ENSMUSP00000037210	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P70175	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-396969|ensembl:ENSMUSP00000085299	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:dlg3_mouse(display_long)|uniprotkb:Dlg3(gene name)|psi-mi:Dlg3(display_short)|uniprotkb:Dlgh3(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_058027.1|refseq:NP_001171249.1|ensembl:ENSMUSG00000000881(gene)|ensembl:ENSMUST00000087984(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|mint:P70175|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-6794361|reactome:R-MMU-8849932|dip:DIP-31585N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:9dR9P876v8QcvPinxtaWzDgpHwE10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:O08967	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-16725278|ensembl:ENSMUSP00000112157|uniprotkb:Q8CI93	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:cyh3_mouse(display_long)|uniprotkb:ARF nucleotide-binding site opener 3(gene name synonym)|uniprotkb:General receptor of phosphoinositides 1(gene name synonym)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 3(gene name synonym)|uniprotkb:SEC7 homolog C(gene name synonym)|uniprotkb:Cyth3(gene name)|psi-mi:Cyth3(display_short)|uniprotkb:Grp1(gene name synonym)|uniprotkb:Pscd3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	ensembl:ENSMUSG00000018001(gene)|ensembl:ENSMUST00000116456(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0090162"(establishment of epithelial cell polarity)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|rcsb pdb:1FGY|rcsb pdb:1FGZ|rcsb pdb:1FHW|rcsb pdb:1FHX|rcsb pdb:1U2B|rcsb pdb:2R09|rcsb pdb:2R0D|rcsb pdb:6BBP|rcsb pdb:6BBQ|reactome:R-MMU-6811438|refseq:NP_035312.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:SUSlHPxCGtFJpZM5a3R/pIpOFXU10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P63034	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-988425|uniprotkb:E9QJX3|uniprotkb:O89099|uniprotkb:P97695|uniprotkb:Q3UP39|ensembl:ENSMUSP00000051423	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:cyh2_mouse(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:SEC7 homolog B(gene name synonym)|uniprotkb:Pscd2(gene name synonym)|uniprotkb:Cyth2(gene name)|psi-mi:Cyth2(display_short)|uniprotkb:Sec7b(gene name synonym)|uniprotkb:ARF nucleotide-binding site opener(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008289"(lipid binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030426"(growth cone)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|rcsb pdb:1U27|rcsb pdb:1U29|reactome:R-MMU-6811438|ensembl:ENSMUSG00000003269(gene)|ensembl:ENSMUST00000056820(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|refseq:NP_001106171.1|refseq:NP_035311.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:voVY4MdVAKJFC14a1Yn/9zYYPgQ10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q9QX11	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-646678|uniprotkb:Q76MU4|uniprotkb:O88817|ensembl:ENSMUSP00000101912	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:cyh1_mouse(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 1(gene name synonym)|uniprotkb:SEC7 homolog A(gene name synonym)|uniprotkb:Cyth1(gene name)|psi-mi:Cyth1(display_short)|uniprotkb:Pscd1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001106169.1|refseq:NP_035310.2|ensembl:ENSMUSG00000017132(gene)|ensembl:ENSMUST00000106305(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008289"(lipid binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|reactome:R-MMU-6811438	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:Cl1DtnqE/FsMVxm9QZko6yMX+Ds10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q60737	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-771698|uniprotkb:Q8R0X4|ensembl:ENSMUSP00000096829	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:csk21_mouse(display_long)|uniprotkb:Csnk2a1(gene name)|psi-mi:Csnk2a1(display_short)|uniprotkb:Ckiia(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_031814.2|refseq:XP_011237574.1|refseq:XP_006498720.1|dip:DIP-32409N|ensembl:ENSMUSG00000074698(gene)|ensembl:ENSMUST00000099224(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q60737|reactome:R-MMU-1483191|reactome:R-MMU-201688|reactome:R-MMU-2514853|reactome:R-MMU-445144|reactome:R-MMU-6804756|reactome:R-MMU-6814122|reactome:R-MMU-8934903|reactome:R-MMU-8939243|reactome:R-MMU-8948751	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:7UK+lLG3t/3xJi7CaiGSCIcxfPg10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q60865	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-647767|uniprotkb:Q6IMN3|uniprotkb:Q7TT26|uniprotkb:Q60758|uniprotkb:Q61620|ensembl:ENSMUSP00000028607|ensembl:ENSMUSP00000106777	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:capr1_mouse(display_long)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:Caprin1(gene name)|psi-mi:Caprin1(display_short)|uniprotkb:Gpiap(gene name synonym)|uniprotkb:Gpiap1(gene name synonym)|uniprotkb:Gpip137(gene name synonym)|uniprotkb:M11s1(gene name synonym)|uniprotkb:G5E5(orf name)|uniprotkb:Rng105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001104759.1|refseq:NP_001104760.1|refseq:NP_001104761.1|refseq:NP_001104762.1|refseq:NP_058019.2|ensembl:ENSMUSG00000027184(gene)|ensembl:ENSMUST00000028607(transcript)|ensembl:ENSMUST00000111147(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q60865	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:e+Dcb+82jx+CoLhlGBbdSG62dPU10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P28652	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P11798	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:Q9ES28	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YA9	uniprotkb:P59281	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-772284|uniprotkb:Q69ZD4|uniprotkb:Q6P9R6|ensembl:ENSMUSP00000036697	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:rhg39_mouse(display_long)|uniprotkb:Arhgap39(gene name)|psi-mi:Arhgap39(display_short)|uniprotkb:D15Wsu169e(gene name synonym)|uniprotkb:Kiaa1688(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727082|imex:IM-26285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_001161760.1|refseq:NP_940812.2|ensembl:ENSMUSG00000033697(gene)|ensembl:ENSMUST00000036176(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007165"(signal transduction)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036020|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9035034	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:Bm7bwXl6puNRxWYdWzAQynmHJ/E10090	rigid:qTnPSeEyuJCDR5mEAsOnozv8Ec0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q6ZPJ3	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-6999453|ensembl:ENSMUSP00000080791|intact:MINT-7034165|uniprotkb:Q60800|uniprotkb:A2A7X3|uniprotkb:Q7TPN2|uniprotkb:Q8BLE8|uniprotkb:Q6PCR9	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ube2o_mouse(display_long)|uniprotkb:E2/E3 hybrid ubiquitin-protein ligase UBE2O(gene name synonym)|uniprotkb:Ube2o(gene name)|psi-mi:Ube2o(display_short)|uniprotkb:Kiaa1734(gene name synonym)|uniprotkb:Ubiquitin-protein ligase O(gene name synonym)|uniprotkb:Ubiquitin carrier protein O(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 of 230 kDa(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 O(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000020802(gene)|ensembl:ENSMUST00000082152(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|mint:Q6ZPJ3|reactome:R-MMU-983168|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_776116.2	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:7DrbsONnQCbVgpH24alvrdtoyJg10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8C7R4	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-8418744|intact:MINT-4114710|ensembl:ENSMUSP00000035328	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:uba6_mouse(display_long)|uniprotkb:Ube1l2(gene name synonym)|uniprotkb:Uba6(gene name)|psi-mi:Uba6(display_short)|uniprotkb:Ubiquitin-activating enzyme E1-like protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_766300.1|ensembl:ENSMUSG00000035898(gene)|ensembl:ENSMUST00000039373(transcript)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019780"(FAT10 activating enzyme activity)|go:"GO:0021764"(amygdala development)|go:"GO:0021766"(hippocampus development)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0060996"(dendritic spine development)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:Q8C7R4|reactome:R-MMU-8866652|reactome:R-MMU-983168	-	-	comment:mint|function:Activates ubiquitin by first adenylating with ATP its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:witNP/bDwm8Ff1J00Frv8HxIOxc10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9QUQ5	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-7385752|ensembl:ENSMUSP00000029311|uniprotkb:Q9QZC0|intact:MINT-144626|uniprotkb:Q62350|uniprotkb:Q9QUQ9	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:trpc4_mouse(display_long)|uniprotkb:Trpc4(gene name)|psi-mi:Trpc4(display_short)|uniprotkb:Trrp4(gene name synonym)|uniprotkb:Receptor-activated cation channel TRP4(gene name synonym)|uniprotkb:Capacitative calcium entry channel Trp4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:XP_006501359.1|ensembl:ENSMUSG00000027748(gene)|ensembl:ENSMUST00000029311(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034703"(cation channel complex)|go:"GO:0034704"(calcium channel complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005460(Transient receptor potential channel 4)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|rcsb pdb:5Z96|rcsb pdb:6JZO|rcsb pdb:7CQP|reactome:R-MMU-3295583|go:"GO:0070509"(calcium ion import)|refseq:NP_058680.1|refseq:NP_001240611.1|dip:DIP-40848N	-	-	comment:mint|function:"Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. TRPC4 deficient mice lack a store-operated calcium entry in endothelial cells"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:anLoCpTwauGHInK3SS326aDsyiw10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9CQE1	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-8334213|intact:MINT-1860977|uniprotkb:Q8VHX9|uniprotkb:B1AWZ4|ensembl:ENSMUSP00000015391	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:nps3b_mouse(display_long)|uniprotkb:Nipsnap3b(gene name)|psi-mi:Nipsnap3b(display_short)|uniprotkb:NipSnap-related protein(gene name synonym)|uniprotkb:Nipsnap3a(gene name synonym)|uniprotkb:Protein NipSnap homolog 3A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_079899.1|ensembl:ENSMUSG00000015247(gene)|ensembl:ENSMUST00000015391(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR012577(NIPSNAP)|mint:Q9CQE1	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:CwF0PpAno8rXKV7pT9XbzvyURQ410090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P61358	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-8401481|intact:MINT-1863099|ensembl:ENSMUSP00000090305|ensembl:ENSMUSP00000102870	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:rl27_mouse(display_long)|uniprotkb:Rpl27(gene name)|psi-mi:Rpl27(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_035419.1|refseq:XP_017170385.1|ensembl:ENSMUSG00000063316(gene)|ensembl:ENSMUST00000077856(transcript)|ensembl:ENSMUST00000107249(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001141(Ribosomal protein L27e)|interpro:IPR005824(KOW)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR018262|interpro:IPR038655|interpro:IPR041991|mint:P61358|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:TLWbAcdRKUb2ijDYjSUa1sbixis10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q62159	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-8419868|uniprotkb:Q3TUN0|intact:MINT-4132345|ensembl:ENSMUSP00000002303|ensembl:ENSMUSP00000102399|ensembl:ENSMUSP00000142697	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:rhoc_mouse(display_long)|uniprotkb:Rhoc(gene name)|psi-mi:Rhoc(display_short)|uniprotkb:Arhc(gene name synonym)|uniprotkb:Silica-induced gene 61 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_031510.2|refseq:NP_001278788.1|ensembl:ENSMUSG00000002233(gene)|ensembl:ENSMUST00000002303(transcript)|ensembl:ENSMUST00000106787(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032420"(stereocilium)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:1902766"(skeletal muscle satellite cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q62159|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5627117|reactome:R-MMU-5663220|reactome:R-MMU-9013106|ensembl:ENSMUST00000196817(transcript)	-	-	comment:mint|function:Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:CPt/q5soDZILGfkngD41Y1U4eys10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q921J2	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-7924728|intact:MINT-4611176|ensembl:ENSMUSP00000030787	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:rheb_mouse(display_long)|uniprotkb:Rheb(gene name)|psi-mi:Rheb(display_short)|uniprotkb:Ras homolog enriched in brain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_444305.2|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2000074"(regulation of type B pancreatic cell development)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR037586|mint:Q921J2|rcsb pdb:4O25|rcsb pdb:4O2L|rcsb pdb:4O2R|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8943724|reactome:R-MMU-9639288|ensembl:ENSMUSG00000028945(gene)|ensembl:ENSMUST00000030787(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)	-	-	function:Not known; binds GTP and exhibits intrinsic GTPase activity|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:hWQL1uMB4w4vwGD6IZBHfOx9UaI10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8CHG7	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-7027510|ensembl:ENSMUSP00000114119|intact:MINT-4133098|uniprotkb:E9QMD0	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:rpgf2_mouse(display_long)|uniprotkb:Rapgef2(gene name)|psi-mi:Rapgef2(display_short)|uniprotkb:Kiaa0313(gene name synonym)|uniprotkb:Pdzgef1(gene name synonym)|uniprotkb:Neural RAP guanine nucleotide exchange protein(gene name synonym)|uniprotkb:PDZ domain-containing guanine nucleotide exchange factor 1(gene name synonym)|uniprotkb:Cyclic nucleotide ras GEF(gene name synonym)|uniprotkb:RA-GEF-1(gene name synonym)|uniprotkb:Ras/Rap1-associating GEF-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:XP_006502317.1|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|go:"GO:0050699"(WW domain binding)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000159(Ras-association)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR018490|interpro:IPR023578|interpro:IPR029071|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030739|interpro:IPR036034|mint:Q8CHG7|reactome:R-MMU-5673001|ensembl:ENSMUSG00000062232(gene)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021591"(ventricular system development)|go:"GO:0021884"(forebrain neuron development)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038180"(nerve growth factor signaling pathway)|ensembl:ENSMUST00000118100(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001764"(neuron migration)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045202"(synapse)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048022"(negative regulation of melanin biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	comment:"fragmentation type: fragment"|comment:mint|comment:homomint|function:"Guanine nucleotide exchange factor (GEF) for Rap1, Rap1B and Rap2 GTPases"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:gH1WVMkcR44bJMCVvh7NctDb5KI10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:O35239	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-7297868|intact:UNK-5361869|uniprotkb:Q7TSK0|ensembl:ENSMUSP00000034832	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ptn9_mouse(display_long)|uniprotkb:Ptpn9(gene name)|psi-mi:Ptpn9(display_short)|uniprotkb:Protein-tyrosine phosphatase MEG2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_062625.2|ensembl:ENSMUSG00000032290(gene)|ensembl:ENSMUST00000034832(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0044306"(neuron projection terminus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036273|interpro:IPR036865	-	-	comment:mint|function:Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:jYpNTWEqwRwpn97yUps1rPOy8ak10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P48437	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-8339964|intact:MINT-4108644|uniprotkb:O88478|uniprotkb:Q3UPV1|uniprotkb:Q543D8|ensembl:ENSMUSP00000010319|ensembl:ENSMUSP00000135066|ensembl:ENSMUSP00000135703	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:prox1_mouse(display_long)|uniprotkb:Prox1(gene name)|psi-mi:Prox1(display_short)|uniprotkb:Homeobox prospero-like protein PROX1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_032963.1|refseq:XP_006497191.1|dip:DIP-58960N|ensembl:ENSMUSG00000010175(gene)|ensembl:ENSMUST00000010319(transcript)|ensembl:ENSMUST00000175916(transcript)|ensembl:ENSMUST00000177288(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001709"(cell fate determination)|go:"GO:0001822"(kidney development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001945"(lymph vessel development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0002194"(hepatocyte cell migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030324"(lung development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046619"(lens placode formation involved in camera-type eye formation)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060214"(endocardium formation)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|go:"GO:0061114"(branching involved in pancreas morphogenesis)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070858"(negative regulation of bile acid biosynthetic process)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090425"(acinar cell differentiation)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1901978"(positive regulation of cell cycle checkpoint)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000979"(positive regulation of forebrain neuron differentiation)|interpro:IPR007738(Homeobox prospero-like)|interpro:IPR009057(Homeodomain-like)|interpro:IPR023082|interpro:IPR037131|interpro:IPR039350|mint:P48437	-	-	function:May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:VmEx8Zsqzi7hoV15t4ja2WFM9is10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8C167	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-8322142|uniprotkb:Q3TR35|uniprotkb:Q6ZQB4|uniprotkb:Q99KJ9|intact:MINT-4123864|uniprotkb:Q8BUP5|intact:UNK-5407141|ensembl:ENSMUSP00000130967	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ppcel_mouse(display_long)|uniprotkb:Prepl(gene name)|psi-mi:Prepl(display_short)|uniprotkb:Kiaa0436(gene name synonym)|uniprotkb:Prolylendopeptidase-like(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001157094.1|refseq:NP_001157096.1|refseq:NP_001157095.1|refseq:NP_666096.3|refseq:XP_006524064.1|ensembl:ENSMUSG00000024127(gene)|ensembl:ENSMUST00000171795(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008233"(peptidase activity)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002470(Peptidase S9A, prolyl oligopeptidase)|interpro:IPR023302|interpro:IPR029058|mint:Q8C167	-	-	function:Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:NFxAQBKEvTFVKk/Eo0yVpju7ago10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8BM65	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-7448157|intact:MINT-8308425|uniprotkb:Q6ZPP8|uniprotkb:Q641L6|uniprotkb:Q8BWV8|uniprotkb:D3Z7K6	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:nyap2_mouse(display_long)|uniprotkb:Nyap2(gene name)|psi-mi:Nyap2(display_short)|uniprotkb:Kiaa1486(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	interpro:IPR029353|interpro:IPR026723|interpro:IPR026722|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0048812"(neuron projection morphogenesis)|interpro:IPR039482|refseq:NP_766437.2|refseq:XP_006496550.1|refseq:XP_006496553.1	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:5JKvz1jGhmb+XGSAyNl/PUBuOe410090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q80U63	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-8437663|intact:MINT-8057620|uniprotkb:Q8R535|uniprotkb:A2A7Y7|uniprotkb:Q80XK3|uniprotkb:Q8BHF0|uniprotkb:Q8BKV5|uniprotkb:A8Y5E4|uniprotkb:Q3V3B8|uniprotkb:Q923X2|uniprotkb:Q80WP4|ensembl:ENSMUSP00000030884|ensembl:ENSMUSP00000101340|ensembl:ENSMUSP00000101341	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:mfn2_mouse(display_long)|uniprotkb:Mfn2(gene name)|psi-mi:Mfn2(display_short)|uniprotkb:Kiaa0214(gene name synonym)|uniprotkb:Marf(gene name synonym)|uniprotkb:Hypertension-related protein 1(gene name synonym)|uniprotkb:Mitochondrial assembly regulatory factor(gene name synonym)|uniprotkb:Transmembrane GTPase MFN2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001272849.1|refseq:NP_001272850.1|refseq:NP_001272851.1|refseq:NP_001272852.1|refseq:NP_573464.2|dip:DIP-60970N|refseq:XP_006538672.1|refseq:XP_006538673.1|refseq:XP_006538674.1|ensembl:ENSMUSG00000029020(gene)|ensembl:ENSMUST00000030884(transcript)|ensembl:ENSMUST00000105715(transcript)|ensembl:ENSMUST00000105716(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031306"(intrinsic component of mitochondrial outer membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR006884(Fzo-like conserved region)|interpro:IPR022812|interpro:IPR027089|interpro:IPR027094|interpro:IPR027417|interpro:IPR030381|mint:Q80U63|reactome:R-MMU-5205685|reactome:R-MMU-9013419|reactome:R-MMU-983231	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:7jDQScOD9jxw/I3zBy5mnbjOF0M10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q03717	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-7511364|uniprotkb:Q8K0D1|intact:MINT-8298631|ensembl:ENSMUSP00000057981|ensembl:ENSMUSP00000147093	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:kcnb1_mouse(display_long)|uniprotkb:Kcnb1(gene name)|psi-mi:Kcnb1(display_short)|uniprotkb:mShab(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv2.1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_032446.2|interpro:IPR004350(Potassium channel, voltage dependent, Kv2.1)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|reactome:R-MMU-1296072|reactome:R-MMU-381676|refseq:XP_017171221.1|refseq:XP_017171222.1|ensembl:ENSMUSG00000050556(gene)|ensembl:ENSMUST00000059826(transcript)|ensembl:ENSMUST00000207917(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001508"(action potential)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:2000671"(regulation of motor neuron apoptotic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003973(Potassium channel, voltage dependent, Kv2)	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:bVGBUW1uvAWqGoo7whe/Oa6Wcv010090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8VI75	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-8418696|uniprotkb:Q3TBW0|uniprotkb:Q99J52|intact:MINT-4098711|ensembl:ENSMUSP00000036555	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ipo4_mouse(display_long)|uniprotkb:Ipo4(gene name)|psi-mi:Ipo4(display_short)|uniprotkb:Imp4a(gene name synonym)|uniprotkb:Ranbp4(gene name synonym)|uniprotkb:Importin-4a(gene name synonym)|uniprotkb:Ran-binding protein 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_077229.4|ensembl:ENSMUSG00000002319(gene)|ensembl:ENSMUST00000047131(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|mint:Q8VI75	-	-	comment:mint|function:"Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. Acts as chaperone for exposed basic domains"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:EWnr36x1avQM6PvFZMPbIQyOk4810090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P24547	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-8317637|uniprotkb:Q61734|intact:MINT-1869864|uniprotkb:Q91Z11|ensembl:ENSMUSP00000079888	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:imdh2_mouse(display_long)|uniprotkb:Impdh2(gene name)|psi-mi:Impdh2(display_short)|uniprotkb:IMPDH-II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_035960.2|ensembl:ENSMUSG00000062867(gene)|ensembl:ENSMUST00000081111(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003938"(IMP dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001093(IMP dehydrogenase/GMP reductase)|interpro:IPR005990(IMP dehydrogenase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR015875(IMP dehydrogenase / GMP reductase, conserved site)|mint:P24547|reactome:R-MMU-6798695|reactome:R-MMU-73817	-	-	function:Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:vLz8hMd9Q8xsT5bB5QlmxCRIXQE10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9R0I7	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-644694|uniprotkb:E9QKY3|uniprotkb:Q7TMM4|ensembl:ENSMUSP00000098763	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ylpm1_mouse(display_long)|uniprotkb:Nuclear protein ZAP3(gene name synonym)|uniprotkb:Ylpm1(gene name)|psi-mi:Ylpm1(display_short)|uniprotkb:Zap(gene name synonym)|uniprotkb:Zap3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0032204"(regulation of telomere maintenance)|interpro:IPR026314|ensembl:ENSMUSG00000021244(gene)|ensembl:ENSMUST00000101202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|interpro:IPR027417|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|mint:Q9R0I7|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:+1aQLNgVl385Mxmx32eA6x9ccDg10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8R5H6	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-774719|uniprotkb:Q91W51|uniprotkb:Q9ERQ9|ensembl:ENSMUSP00000019975|ensembl:ENSMUSP00000101148	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:wasf1_mouse(display_long)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Wasf1(gene name)|psi-mi:Wasf1(display_short)|uniprotkb:Wave1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_114083.1|refseq:XP_006512995.1|ensembl:ENSMUSG00000019831(gene)|ensembl:ENSMUST00000019975(transcript)|ensembl:ENSMUST00000105509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8R5H6|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:t+4F2ap7lNjE/AGuIwMhel4YknU10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9R1R2	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-775991|uniprotkb:Q3UMU5|ensembl:ENSMUSP00000053384|ensembl:ENSMUSP00000102401|ensembl:ENSMUSP00000114822	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:trim3_mouse(display_long)|uniprotkb:RING finger protein 22(gene name synonym)|uniprotkb:RING finger protein HAC1(gene name synonym)|uniprotkb:Trim3(gene name)|psi-mi:Trim3(display_short)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Rnf22(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001272799.1|refseq:NP_001272800.1|refseq:NP_001272802.1|refseq:NP_061368.1|ensembl:ENSMUSG00000036989(gene)|ensembl:ENSMUST00000057525(transcript)|ensembl:ENSMUST00000106789(transcript)|ensembl:ENSMUST00000147044(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001258(NHL repeat)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR017907|interpro:IPR027370|mint:Q9R1R2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:fOQH1BPgmOXrJXOb8VYYFpNX0UQ10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:O55013	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-1172223|ensembl:ENSMUSP00000030660	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:tppc3_mouse(display_long)|uniprotkb:BET3 homolog(gene name synonym)|uniprotkb:Trappc3(gene name)|psi-mi:Trappc3(display_short)|uniprotkb:Bet3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000028847(gene)|ensembl:ENSMUST00000030660(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030008"(TRAPP complex)|go:"GO:0033106"(cis-Golgi network membrane)|interpro:IPR007194("Transport protein particle (TRAPP) component, Bet3")|interpro:IPR016721(TRAPP I complex, Bet3)|interpro:IPR024096|mint:O55013|rcsb pdb:1WC8|rcsb pdb:1WC9|rcsb pdb:2J3R|rcsb pdb:2J3T|rcsb pdb:2J3W|rcsb pdb:2PWN|reactome:R-MMU-204005|reactome:R-MMU-8876198|refseq:NP_038746.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:VoANjtqe/P6oziS0WRdNJprvMUI10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9CYZ2	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-911872|ensembl:ENSMUSP00000117690|uniprotkb:Q3TVY1	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:tpd54_mouse(display_long)|uniprotkb:Tumor protein D52-like 2(gene name synonym)|uniprotkb:Tpd52l2(gene name)|psi-mi:Tpd52l2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000000827(gene)|ensembl:ENSMUST00000149163(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR007327(Tumor protein D52)|mint:Q9CYZ2|refseq:NP_079758.2|refseq:NP_001278126.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:8kwPlEwMV5kwUD6FlCqgXoG+0DI10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:B2RWJ3	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-16727428|ensembl:ENSMUSP00000127341|ensembl:ENSMUSP00000130974	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:tm240_mouse(display_long)|uniprotkb:Tmem240(gene name)|psi-mi:Tmem240(display_short)|uniprotkb:Gm5151(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000084845(gene)|ensembl:ENSMUST00000127188(transcript)|ensembl:ENSMUST00000147721(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0097060"(synaptic membrane)|interpro:IPR027947|refseq:NP_001094976.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:7R2zdZkIO8HRveIFrshkFRvRbs010090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8CC35	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-774691|uniprotkb:Q99JI0|ensembl:ENSMUSP00000125272	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:synpo_mouse(display_long)|uniprotkb:Synpo(gene name)|psi-mi:Synpo(display_short)|uniprotkb:Kiaa1029(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000043079(gene)|ensembl:ENSMUST00000143275(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0097444"(spine apparatus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098886"(modification of dendritic spine)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099588"(positive regulation of postsynaptic cytosolic calcium concentration)|go:"GO:1905355"(spine apparatus assembly)|interpro:IPR028753	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:X85lScd6IVk7dALEA55e9/YC9Rw10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:F6SEU4	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-5797569|ensembl:ENSMUSP00000141686	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q68FG2	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-2255511|ensembl:ENSMUSP00000008991	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:q68fg2_mouse(display_long)|uniprotkb:Sptbn2(gene name)|psi-mi:Sptbn2(display_short)|uniprotkb:Spnb3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_067262.1|refseq:XP_006531767.1|refseq:XP_006531768.1|ensembl:ENSMUSG00000067889(gene)|ensembl:ENSMUST00000008991(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008091"(spectrin)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0030534"(adult behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051693"(actin filament capping)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098918"(structural constituent of synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:0099189"(postsynaptic spectrin-associated cytoskeleton)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-MMU-2132295|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:2F7U0dl21KxXpc9Z2sk7D/wzQvM10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q62261	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P16546	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-911063|uniprotkb:A3KGU6|uniprotkb:Q8K380|uniprotkb:Q9CT05|uniprotkb:A3KGU8|ensembl:ENSMUSP00000092697	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:sptn1_mouse(display_long)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym)|uniprotkb:Spta2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	dip:DIP-37712N|ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000095083(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032437"(cuticular plate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:P16546|reactome:R-MMU-264870|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:UVB6Kv+PBlqDH3OLoGjxm5oYVPQ10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q61548	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-775174|uniprotkb:Q61547|uniprotkb:Q8K0D4	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ap180_mouse(display_long)|uniprotkb:Clathrin coat-associated protein AP180(gene name synonym)|uniprotkb:91 kDa synaptosomal-associated protein(gene name synonym)|uniprotkb:Phosphoprotein F1-20(gene name synonym)|uniprotkb:Snap91(gene name)|psi-mi:Snap91(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001264911.1|refseq:NP_001264915.1|refseq:NP_038697.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|refseq:XP_006510957.1|refseq:XP_006510963.1|interpro:IPR030428|mint:Q61548|go:"GO:0000149"(SNARE binding)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043679"(axon terminus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1904006"(negative regulation of phospholipase D activity)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:uew/lk0YJ8j0CQULEZaC/qLlLF810090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8JZR6	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-16727394|ensembl:ENSMUSP00000023776|uniprotkb:Q3TAV7|uniprotkb:Q6A004|uniprotkb:Q8BYI7|uniprotkb:Q9JKV6	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:s4a8_mouse(display_long)|uniprotkb:Electroneutral Na+-driven Cl-HCO3 exchanger(gene name synonym)|uniprotkb:Solute carrier family 4 member 8(gene name synonym)|uniprotkb:k-NBC3(gene name synonym)|uniprotkb:Slc4a8(gene name)|psi-mi:Slc4a8(display_short)|uniprotkb:Kiaa0739(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000023032(gene)|ensembl:ENSMUST00000023776(transcript)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008510"("sodium:bicarbonate symporter activity")|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030425"(dendrite)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032280"(symmetric synapse)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043679"(axon terminus)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0097386"(glial cell projection)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR003024(Sodium bicarbonate cotransporter)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|reactome:R-MMU-425381|go:"GO:0042391"(regulation of membrane potential)|refseq:NP_001334031.1|refseq:NP_067505.2|refseq:XP_017172207.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:395ge31lQ5KGGPDvC6KdvfFTadw10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q4ACU6	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:D3YZU1	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-2314988|ensembl:ENSMUSP00000103571	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:shan1_mouse(display_long)|uniprotkb:Shank1(gene name)|psi-mi:Shank1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001029287.1|refseq:XP_006540927.1|ensembl:ENSMUSG00000038738(gene)|ensembl:ENSMUST00000107938(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:TbxBmjjabypLqTlAx9zbkSAAzpk10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8VD37	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-776269|uniprotkb:A7BFW0|uniprotkb:Q3UFU3|uniprotkb:Q3UGA0|uniprotkb:Q8BXX4|uniprotkb:Q8C034|uniprotkb:Q9CXT2|ensembl:ENSMUSP00000079553	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:sgip1_mouse(display_long)|uniprotkb:Endophilin-3-interacting protein(gene name synonym)|uniprotkb:Sgip1(gene name)|psi-mi:Sgip1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_659155.1|refseq:NP_001272788.1|refseq:NP_001272789.1|refseq:NP_001272791.1|refseq:XP_006503491.1|refseq:XP_017175890.1|ensembl:ENSMUSG00000028524(gene)|ensembl:ENSMUST00000080728(transcript)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098793"(presynapse)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR018808|interpro:IPR028565|interpro:IPR036168|interpro:IPR037984|mint:Q8VD37|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:5TUgNAM4+5qY6EfbMvqhjc/i3/U10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q6ZPE2	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-771895|uniprotkb:Q4QQM2|uniprotkb:Q8BK68|uniprotkb:Q8K2Z0|uniprotkb:B2RXQ1|uniprotkb:B2RXX4|uniprotkb:B7ZWK2|ensembl:ENSMUSP00000120725	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:mtmr5_mouse(display_long)|uniprotkb:SET-binding factor 1(gene name synonym)|uniprotkb:Sbf1(gene name)|psi-mi:Sbf1(display_short)|uniprotkb:Kiaa3020(gene name synonym)|uniprotkb:Mtmr5(gene name synonym)|uniprotkb:Inactive phosphatidylinositol 3-phosphatase 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001074499.2|refseq:NP_001164032.1|ensembl:ENSMUSG00000036529(gene)|ensembl:ENSMUST00000123791(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0016604"(nuclear body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001194(DENN)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR004182(GRAM)|interpro:IPR005112(dDENN)|interpro:IPR005113(uDENN)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022096|interpro:IPR029021|interpro:IPR030564|interpro:IPR030574|interpro:IPR037516|interpro:IPR043153|rcsb pdb:1V5U|reactome:R-MMU-1483248|reactome:R-MMU-8876198	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:EXetiIj59Q3tqiAmw422ux9X6NY10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8K0T0	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-445349|uniprotkb:Q8K4S4|ensembl:ENSMUSP00000077594	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:rtn1_mouse(display_long)|uniprotkb:Neuroendocrine-specific protein(gene name synonym)|uniprotkb:Rtn1(gene name)|psi-mi:Rtn1(display_short)|uniprotkb:Nsp(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_703187.2|refseq:NP_001273377.1|ensembl:ENSMUSG00000021087(gene)|ensembl:ENSMUST00000078505(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR003388(Reticulon)|mint:Q8K0T0	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:5COULbIuLu52T1pxYUiFehIhUns10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8BSK8	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-646423|uniprotkb:Q5SWG1|uniprotkb:Q8CHX0|ensembl:ENSMUSP00000119715	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ks6b1_mouse(display_long)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001107806.1|ensembl:ENSMUSG00000020516(gene)|ensembl:ENSMUST00000154617(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043201"(response to leucine)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-MMU-166208	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:uJPo7NVO75oHLm1/ZRG3W8uF//s10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P63001	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P63318	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-397096|uniprotkb:P05697|ensembl:ENSMUSP00000097874	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:kpcg_mouse(display_long)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_035232.1|ensembl:ENSMUSG00000078816(gene)|ensembl:ENSMUST00000100301(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0005829"(cytosol)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|interpro:IPR020454|interpro:IPR035892|mint:P63318|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-416993|reactome:R-MMU-5099900|reactome:R-MMU-76005	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P16054	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-298451|ensembl:ENSMUSP00000094873|ensembl:ENSMUSP00000094874	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:kpce_mouse(display_long)|uniprotkb:Prkce(gene name)|psi-mi:Prkce(display_short)|uniprotkb:Pkce(gene name synonym)|uniprotkb:Pkcea(gene name synonym)|uniprotkb:nPKC-epsilon(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000045038(gene)|ensembl:ENSMUST00000097274(transcript)|ensembl:ENSMUST00000097275(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027274|interpro:IPR034669|interpro:IPR035892|reactome:R-MMU-114508|reactome:R-MMU-1250196|reactome:R-MMU-1489509|reactome:R-MMU-2029485|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0005829"(cytosol)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035276"(ethanol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071944"(cell periphery)|go:"GO:0043278"(response to morphine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046872"(metal ion binding)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001031"(positive regulation of cellular glucuronidation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050996"(positive regulation of lipid catabolic process)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0051301"(cell division)|refseq:NP_035234.1|dip:DIP-31066N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:LBpr5ejW6fnkKwlXL6akJYv3H1M10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P68404	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P63087	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-80040|uniprotkb:O09186|uniprotkb:O09189|uniprotkb:P37139|uniprotkb:Q64679|ensembl:ENSMUSP00000099587	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:pp1g_mouse(display_long)|uniprotkb:Ppp1cc(gene name)|psi-mi:Ppp1cc(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|rcsb pdb:4V0U|rcsb pdb:4V0V|rcsb pdb:4V0W|rcsb pdb:4V0X|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-68877|reactome:R-MMU-9648025|go:"GO:0005856"(cytoskeleton)|ensembl:ENSMUSG00000004455(gene)|ensembl:ENSMUST00000102528(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_038664.2|refseq:XP_006508478.1|refseq:XP_006530263.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:67YjuOIxqIl6Qj+bQnfLBo4iRAg10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q7M6Y3	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-775438|uniprotkb:Q3TS04|uniprotkb:Q811P1|uniprotkb:Q8BUF6|uniprotkb:Q8CIH8|uniprotkb:Q8R0A9|uniprotkb:Q8R3E1|uniprotkb:Q8VDN5|uniprotkb:Q921L0|ensembl:ENSMUSP00000146501	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:pical_mouse(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Fit1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_666306.2|refseq:NP_001239453.1|refseq:NP_001239449.1|refseq:NP_001239450.1|refseq:NP_001239451.1|refseq:NP_001239452.1|ensembl:ENSMUSG00000039361(gene)|ensembl:ENSMUST00000207484(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR030412|mint:Q7M6Y3|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-9696264	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:aMlKeX8FC7WnTwQRsfHnKEiQKhs10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:E9Q3L2	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-773641|uniprotkb:Q3UVT5|uniprotkb:Q6DIC7|uniprotkb:Q7TNG2|uniprotkb:Q80Y45	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:pi4ka_mouse(display_long)|uniprotkb:Pik4(gene name synonym)|uniprotkb:Pik4ca(gene name synonym)|uniprotkb:Pi4ka(gene name)|psi-mi:Pi4ka(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001001983.2|interpro:IPR016024(Armadillo-type fold)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR018936|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR042236|refseq:XP_006522097.1|interpro:IPR036940|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0046786"(viral replication complex formation and maintenance)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|reactome:R-MMU-1483248|reactome:R-MMU-1660514|mint:E9Q3L2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:IndUgD7njY39mo58MVLNKGSeD4c10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q2M3X8	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-2931675|ensembl:ENSMUSP00000115207|ensembl:ENSMUSP00000122232|uniprotkb:G5E8P7|uniprotkb:B1B1B5|uniprotkb:B1B1B6|uniprotkb:B1B1B7|uniprotkb:Q80VL9|uniprotkb:Q8C873	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:phar1_mouse(display_long)|uniprotkb:Phactr1(gene name)|psi-mi:Phactr1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000054728(gene)|ensembl:ENSMUST00000128646(transcript)|ensembl:ENSMUST00000149235(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0045202"(synapse)|go:"GO:0048870"(cell motility)|go:"GO:0140059"(dendrite arborization)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR004018(RPEL repeat)|interpro:IPR029987|rcsb pdb:4B1U|rcsb pdb:4B1V|rcsb pdb:4B1W|rcsb pdb:4B1X|rcsb pdb:4B1Y|rcsb pdb:4B1Z|refseq:XP_011242697.1|refseq:NP_001005740.1|refseq:XP_017170971.1|refseq:XP_017170972.1|refseq:NP_001289564.1|refseq:NP_001289565.1|refseq:XP_006516968.1|refseq:XP_006516969.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:S82qOO2lYBH7U4x+tq9ZTibCim410090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:O89084	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-16727353|ensembl:ENSMUSP00000037025|uniprotkb:Q8R078|uniprotkb:Q9JHQ4|uniprotkb:Q9QX48|uniprotkb:Q9QX49|uniprotkb:Q9QXI8	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:pde4a_mouse(display_long)|uniprotkb:Pde4a(gene name)|psi-mi:Pde4a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000032177(gene)|ensembl:ENSMUST00000039413(transcript)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006198"(cAMP catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0030552"(cAMP binding)|go:"GO:0035690"|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR036971|interpro:IPR040844|reactome:R-MMU-180024|reactome:R-MMU-418555|refseq:NP_062772.3|refseq:NP_899668.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:VqmB1Wv+lB9Tu1P9f8jeMh7yRp810090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9WU78	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-641897|uniprotkb:Q3TED2|uniprotkb:O88695|uniprotkb:O89014|uniprotkb:Q8BSL8|uniprotkb:Q8R0H5|uniprotkb:Q99LR3|uniprotkb:Q9QZN8|ensembl:ENSMUSP00000035086	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:pdc6i_mouse(display_long)|uniprotkb:ALG-2-interacting protein X(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:E2F1-inducible protein(gene name synonym)|uniprotkb:Eig2(gene name synonym)|uniprotkb:Pdcd6ip(gene name)|psi-mi:Pdcd6ip(display_short)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Alix(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001158149.1|refseq:NP_001158150.1|refseq:NP_035182.2|ensembl:ENSMUSG00000032504(gene)|ensembl:ENSMUST00000035086(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:0043209"(myelin sheath)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q9WU78|reactome:R-MMU-5213460|reactome:R-MMU-5675482|dip:DIP-41418N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:mHHuK3MilHPoz71+777a7S2Ijrw10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:O88643	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-457240	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:pak1_mouse(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-A(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)|uniprotkb:Paka(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-445144|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|dip:DIP-32847N|mint:O88643	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:96Cg20ZJuaGLWTlK9dOIdVHQLGQ10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9Z1M0	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-16727242|ensembl:ENSMUSP00000098303	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:p2rx7_mouse(display_long)|uniprotkb:ATP receptor(gene name synonym)|uniprotkb:P2Z receptor(gene name synonym)|uniprotkb:Purinergic receptor(gene name synonym)|uniprotkb:P2rx7(gene name)|psi-mi:P2rx7(display_short)|uniprotkb:P2x7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000029468(gene)|ensembl:ENSMUST00000100737(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001614"(purinergic nucleotide receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001845"(phagolysosome assembly)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004931"(extracellularly ATP-gated cation channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006649"(phospholipid transfer to membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008219"(cell death)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010467"(gene expression)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012501"(programmed cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016485"(protein processing)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032060"(bleb assembly)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0033198"(response to ATP)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0035590"(purinergic nucleotide receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043132"(NAD transport)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046931"(pore complex assembly)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070230"(positive regulation of lymphocyte apoptotic process)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1904172"(positive regulation of bleb assembly)|interpro:IPR001429(P2X purinoreceptor)|interpro:IPR003050(P2X7 purinoceptor)|interpro:IPR027309|reactome:R-MMU-139853|reactome:R-MMU-418346|reactome:R-MMU-844456|refseq:NP_035157.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:g5bHl01xZ2zYfqMml7BWrpdzFFQ10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P58281	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-776163|uniprotkb:Q3ULA5|uniprotkb:Q8BKU7|uniprotkb:Q8BLL3|uniprotkb:Q8BM08|uniprotkb:Q8R3J7|uniprotkb:A6H6Q3|ensembl:ENSMUSP00000124223	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:opa1_mouse(display_long)|uniprotkb:Optic atrophy protein 1 homolog(gene name synonym)|uniprotkb:Large GTP-binding protein(gene name synonym)|uniprotkb:Opa1(gene name)|psi-mi:Opa1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_598513.1|refseq:XP_006522720.1|ensembl:ENSMUSG00000038084(gene)|ensembl:ENSMUST00000160597(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:P58281|reactome:R-MMU-169911	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:cj1HZs8CYUuCBy4KhYmtO/lvmUk10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:O08919	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-773000|uniprotkb:Q4QQQ2|uniprotkb:Q6NVG8|ensembl:ENSMUSP00000078245	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:numbl_mouse(display_long)|uniprotkb:Numbl(gene name)|psi-mi:Numbl(display_short)|uniprotkb:Nbl(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_035080.2|ensembl:ENSMUSG00000063160(gene)|ensembl:ENSMUST00000079258(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007409"(axonogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019538"(protein metabolic process)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021849"(neuroblast division in subventricular zone)|go:"GO:0030900"(forebrain development)|go:"GO:0034332"(adherens junction organization)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:2qFX1x26D9ZwQAsK/wDEwyevlD410090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P15209	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-309647|uniprotkb:Q3TUF9|uniprotkb:Q80WU0|uniprotkb:Q91XJ9|ensembl:ENSMUSP00000078757|ensembl:ENSMUSP00000153553	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ntrk2_mouse(display_long)|uniprotkb:Ntrk2(gene name)|psi-mi:Ntrk2(display_short)|uniprotkb:Trkb(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym)|uniprotkb:GP145-TrkB/GP95-TrkB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001269890.1|refseq:NP_001020245.1|refseq:NP_032771.1|refseq:XP_006517212.1|refseq:XP_006517215.1|go:"GO:0002020"(protease binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|ensembl:ENSMUSG00000055254(gene)|ensembl:ENSMUST00000079828(transcript)|ensembl:ENSMUST00000225488(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0043679"(axon terminus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0098794"(postsynapse)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:0043204"(perikaryon)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0043235"(receptor complex)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|go:"GO:0043408"(regulation of MAPK cascade)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:P15209|reactome:R-MMU-9026527|reactome:R-MMU-9028731|reactome:R-MMU-9032759|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|refseq:XP_017170909.1|refseq:XP_017170908.1|dip:DIP-5722N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:NaGSeT7Pkwq8OE3rxvyTKEAU7mU10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P46460	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-398006|uniprotkb:A2A646|uniprotkb:Q8BQ65|uniprotkb:Q8C3R2|uniprotkb:Q8CCT9|uniprotkb:Q8CEF0|uniprotkb:Q923C6|ensembl:ENSMUSP00000099364	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:nsf_mouse(display_long)|uniprotkb:Nsf(gene name)|psi-mi:Nsf(display_short)|uniprotkb:Skd2(gene name synonym)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 2"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_032766.2|ensembl:ENSMUSG00000034187(gene)|ensembl:ENSMUST00000103075(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46460|reactome:R-MMU-204005|reactome:R-MMU-416993|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811438|reactome:R-MMU-6811440	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:mqNfvBVWEdD4caFZug82c88vwE410090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q11011	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-2309833|uniprotkb:Q3UZE0|uniprotkb:Q91VJ8|uniprotkb:Q5PR74|ensembl:ENSMUSP00000001480	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:psa_mouse(display_long)|uniprotkb:Npepps(gene name)|psi-mi:Npepps(display_short)|uniprotkb:Psa(gene name synonym)|uniprotkb:Cytosol alanyl aminopeptidase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_032968.2|ensembl:ENSMUSG00000001441(gene)|ensembl:ENSMUST00000001480(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042277"(peptide binding)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR024571|interpro:IPR027268|interpro:IPR034016|interpro:IPR042097|mint:Q11011|reactome:R-MMU-983168	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:3bY21UZD4p6P4+IIJstPb9R27LE10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P08553	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-445188|uniprotkb:A2VCT5|uniprotkb:Q0VDM8|uniprotkb:Q3HRJ6|uniprotkb:Q3TNS4|uniprotkb:Q3TPK2|uniprotkb:Q61961|uniprotkb:Q8BQ20	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:nfm_mouse(display_long)|uniprotkb:Neurofilament triplet M protein(gene name synonym)|uniprotkb:160 kDa neurofilament protein(gene name synonym)|uniprotkb:Neurofilament 3(gene name synonym)|uniprotkb:Nefm(gene name)|psi-mi:Nefm(display_short)|uniprotkb:Nef3(gene name synonym)|uniprotkb:Nfm(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_032717.2|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR002957(Keratin, type I)|interpro:IPR039008|interpro:IPR027697|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030424"(axon)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|mint:P08553	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:2HBUZIEhbbrfamAhbq7gyuRUaTk10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P08551	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-445199|uniprotkb:Q8K0Z0|ensembl:ENSMUSP00000022639	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:nfl_mouse(display_long)|uniprotkb:Neurofilament triplet L protein(gene name synonym)|uniprotkb:68 kDa neurofilament protein(gene name synonym)|uniprotkb:Nefl(gene name)|psi-mi:Nefl(display_short)|uniprotkb:Nfl(gene name synonym)|uniprotkb:Nf68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_035040.1|ensembl:ENSMUSG00000022055(gene)|ensembl:ENSMUST00000022639(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027692|interpro:IPR039008|mint:P08551|reactome:R-MMU-438066|reactome:R-MMU-5673001|go:"GO:0098981"(cholinergic synapse)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0040011"(locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051258"(protein polymerization)|go:"GO:0051412"(response to corticosterone)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060074"(synapse maturation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|dip:DIP-31944N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:E8KK2ppZXyLXIlFZp/pjXv7GBEU10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P19246	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-1634658|uniprotkb:A1E2H9|uniprotkb:Q5SVF6|uniprotkb:Q61959|ensembl:ENSMUSP00000091061	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:nfh_mouse(display_long)|uniprotkb:Nefh(gene name)|psi-mi:Nefh(display_short)|uniprotkb:Kiaa0845(gene name synonym)|uniprotkb:Nfh(gene name synonym)|uniprotkb:Neurofilament triplet H protein(gene name synonym)|uniprotkb:200 kDa neurofilament protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_035034.2|ensembl:ENSMUSG00000020396(gene)|ensembl:ENSMUST00000093369(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001552"(ovarian follicle atresia)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0007420"(brain development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015643"(toxic substance binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031103"(axon regeneration)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0061564"(axon development)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:0150017"(basal proximal dendrite)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR010790(Protein of unknown function DUF1388)|interpro:IPR018039|interpro:IPR033183|interpro:IPR039008|mint:P19246	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:1Fs10v+/s87EA3iRKeuxNEijJ5o10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P28660	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9Z0E0	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-775082|uniprotkb:Q3TCW4|uniprotkb:Q80TW1|uniprotkb:Q91YH7|uniprotkb:Q9CW81|uniprotkb:Q9QUQ0|ensembl:ENSMUSP00000030637|ensembl:ENSMUSP00000101722	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ncdn_mouse(display_long)|uniprotkb:Sfap75(gene name synonym)|uniprotkb:Norbin(gene name synonym)|uniprotkb:M-Sema F-associating protein of 75 kDa(gene name synonym)|uniprotkb:Ncdn(gene name)|psi-mi:Ncdn(display_short)|uniprotkb:Kiaa0607(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_036116.3|refseq:XP_006503181.1|refseq:XP_006503182.1|ensembl:ENSMUSG00000028833(gene)|ensembl:ENSMUST00000030637(transcript)|ensembl:ENSMUST00000106116(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045453"(bone resorption)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0098794"(postsynapse)|interpro:IPR008709(Neurochondrin)|interpro:IPR016024(Armadillo-type fold)|mint:Q9Z0E0	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:afzLC/h+kiexMllkeyxpn1btb1U10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P55066	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-774845|uniprotkb:Q6P1E3|uniprotkb:Q8C4F8	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ncan_mouse(display_long)|uniprotkb:Chondroitin sulfate proteoglycan 3(gene name synonym)|uniprotkb:Ncan(gene name)|psi-mi:Ncan(display_short)|uniprotkb:Cspg3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_031815.2|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR018378|interpro:IPR016187(C-type lectin fold)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR000538(Link)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR036179|mint:P55066|go:"GO:0001501"(skeletal system development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007417"(central nervous system development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0045202"(synapse)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0072534"(perineuronal net)|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|reactome:R-MMU-3000178	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:FbEuo7LHWAZLqfPi0o0JVHNX4Y410090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q99104	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-400199|uniprotkb:E9PUE5|ensembl:ENSMUSP00000116028	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:myo5a_mouse(display_long)|uniprotkb:Myo5a(gene name)|psi-mi:Myo5a(display_short)|uniprotkb:Dilute(gene name synonym)|uniprotkb:Dilute myosin heavy chain, non-muscle(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_034994.2|ensembl:ENSMUSG00000034593(gene)|ensembl:ENSMUST00000123128(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000149"(SNARE binding)|go:"GO:0001726"(ruffle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007601"(visual perception)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014046"(dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031585"(regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031982"(vesicle)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032433"(filopodium tip)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042476"(odontogenesis)|go:"GO:0042552"(myelination)|go:"GO:0042641"(actomyosin)|go:"GO:0042642"(actomyosin, myosin complex part)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043473"(pigmentation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0050808"(synapse organization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051643"(endoplasmic reticulum localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099089"(establishment of endoplasmic reticulum localization to postsynapse)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0099640"(axo-dendritic protein transport)|go:"GO:0150103"(reactive gliosis)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|go:"GO:0030318"(melanocyte differentiation)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR037988|mint:Q99104|rcsb pdb:2IX7|rcsb pdb:3WB8|rcsb pdb:4KP3|rcsb pdb:4ZLK|rcsb pdb:6KU0|reactome:R-MMU-2029482|interpro:IPR002710(Dilute)|go:"GO:0030141"(secretory granule)|dip:DIP-29542N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:8QtBlLL4DqB3An4CoCFVmvBEXBg10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8K310	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-1216295|ensembl:ENSMUSP00000125761|ensembl:ENSMUSP00000158074|ensembl:ENSMUSP00000158537	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:matr3_mouse(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_034901.2|rcsb pdb:1X4F|rcsb pdb:1X4D|ensembl:ENSMUSG00000037236(gene)|ensembl:ENSMUST00000166793(transcript)|ensembl:ENSMUST00000235199(transcript)|ensembl:ENSMUST00000237744(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:Q8K310	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:AwtFbI+oRfha+mn/v3yzG6bNXYg10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9QXZ0	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-643248|intact:EBI-2658096|uniprotkb:B1ARU3|uniprotkb:Q4PLL5|uniprotkb:P97394|uniprotkb:P97395|uniprotkb:P97396	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:macf1_mouse(display_long)|uniprotkb:Actin cross-linking family 7(gene name synonym)|uniprotkb:Macf1(gene name)|psi-mi:Macf1(display_short)|uniprotkb:Acf7(gene name synonym)|uniprotkb:Aclp7(gene name synonym)|uniprotkb:Macf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR002017(Spectrin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR001101(Plectin repeat)|interpro:IPR018159|interpro:IPR001452(Src homology-3)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0008104"(protein localization)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|mint:Q9QXZ0|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:niJxpkI45VTa5x73A1tuX/aLXgo10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8BHA1	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-16727221|ensembl:ENSMUSP00000061906|uniprotkb:Q14AD4	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:lrc24_mouse(display_long)|uniprotkb:Lrrc24(gene name)|psi-mi:Lrrc24(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000033707(gene)|ensembl:ENSMUST00000049956(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0051965"(positive regulation of synapse assembly)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|refseq:NP_932787.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:lbc3mcgYUo30KLHTh8cw/HkzREc10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P28740	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-776122|uniprotkb:O54744|uniprotkb:Q91W03|ensembl:ENSMUSP00000022204	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:kif2a_mouse(display_long)|uniprotkb:Kif2a(gene name)|psi-mi:Kif2a(display_short)|uniprotkb:Kif2(gene name synonym)|uniprotkb:Kns2(gene name synonym)|uniprotkb:Kinesin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001139251.1|refseq:XP_006517602.1|ensembl:ENSMUSG00000021693(gene)|ensembl:ENSMUST00000022204(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0051301"(cell division)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097228"(sperm principal piece)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P28740|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-6811434|reactome:R-MMU-68877|reactome:R-MMU-9648025|reactome:R-MMU-983189	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:xPWg0rzeKQooA3AM2Ics+e/QnRM10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8R0S2	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-772277|uniprotkb:Q3TZC3|uniprotkb:Q5DU15|ensembl:ENSMUSP00000098712	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:iqec1_mouse(display_long)|uniprotkb:Iqsec1(gene name)|psi-mi:Iqsec1(display_short)|uniprotkb:Kiaa0763(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001127855.1|ensembl:ENSMUSG00000034312(gene)|ensembl:ENSMUST00000101153(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR030737|interpro:IPR033742|interpro:IPR035999	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:BZg7CaLndE4ak8KXs34YFf9iBRQ10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P35436	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-400115|ensembl:ENSMUSP00000032331|ensembl:ENSMUSP00000111501|ensembl:ENSMUSP00000142900	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:nmde1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:Grin2a(gene name)|psi-mi:Grin2a(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_032196.2|reactome:R-MMU-8849932|reactome:R-MMU-9609736|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-438066|go:"GO:0098839"(postsynaptic density membrane)|ensembl:ENSMUSG00000059003(gene)|ensembl:ENSMUST00000032331(transcript)|ensembl:ENSMUST00000115835(transcript)|ensembl:ENSMUST00000199708(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040011"(locomotion)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|refseq:XP_006521857.1|dip:DIP-31567N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:5DMFDOh6NuFArDtKp2gp2IpmhWQ10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q921M4	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-298519|ensembl:ENSMUSP00000109004|uniprotkb:A2AN43|uniprotkb:A2AN47	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:goga2_mouse(display_long)|uniprotkb:Golga2(gene name)|psi-mi:Golga2(display_short)|uniprotkb:130 kDa cis-Golgi matrix protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0019905"(syntaxin binding)|refseq:NP_001074437.1|ensembl:ENSMUSG00000002546(gene)|ensembl:ENSMUST00000113377(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005874"(microtubule)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051225"(spindle assembly)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051645"(Golgi localization)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR024858|interpro:IPR043937|interpro:IPR043976|mint:Q921M4|reactome:R-MMU-162658|reactome:R-MMU-204005|reactome:R-MMU-6807878|reactome:R-MMU-9013148|reactome:R-MMU-9013405|refseq:XP_006498556.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:GMrTr2bHQ0lyJ7MV2kNF5+7fhAk10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P15105	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-444858|uniprotkb:Q3TRK7|uniprotkb:Q64432|uniprotkb:Q91VC6|ensembl:ENSMUSP00000083375|ensembl:ENSMUSP00000123157	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:glna_mouse(display_long)|uniprotkb:Glutamate--ammonia ligase(gene name synonym)|uniprotkb:Glul(gene name)|psi-mi:Glul(display_short)|uniprotkb:Glns(gene name synonym)|uniprotkb:Palmitoyltransferase GLUL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_032157.2|go:"GO:0030145"(manganese ion binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0097386"(glial cell projection)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR008146(Glutamine synthetase, catalytic region)|interpro:IPR008147(Glutamine synthetase, beta-Grasp)|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR027302|interpro:IPR027303|interpro:IPR036651|mint:P15105|reactome:R-MMU-210455|reactome:R-MMU-8964539|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|ensembl:ENSMUSG00000026473(gene)|ensembl:ENSMUST00000086199(transcript)|ensembl:ENSMUST00000140685(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0004356"(glutamate-ammonia ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006542"(glutamine biosynthetic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0016595"(glutamate binding)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019676"(ammonia assimilation cycle)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:j6R9fxGLKpiREWpecpdnBY9ftoo10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8K1B8	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-12603349|ensembl:ENSMUSP00000037858	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:urp2_mouse(display_long)|uniprotkb:Fermt3(gene name)|psi-mi:Fermt3(display_short)|uniprotkb:Kind3(gene name synonym)|uniprotkb:Urp2(gene name synonym)|uniprotkb:Kindlin-3(gene name synonym)|uniprotkb:Unc-112-related protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000024965(gene)|ensembl:ENSMUST00000040772(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005178"(integrin binding)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033622"(integrin activation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042995"(cell projection)|go:"GO:0070527"(platelet aggregation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR035963|interpro:IPR037843|interpro:IPR040790|rcsb pdb:5L81|reactome:R-MMU-114608|interpro:IPR037837|refseq:NP_722490.1|refseq:XP_006526656.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:abQWJ455PRZh9JISQXv3eql4XFY10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:F8VPU2	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-16725343|ensembl:ENSMUSP00000026635|uniprotkb:C4IXU2	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:farp1_mouse(display_long)|uniprotkb:FERM, RhoGEF and pleckstrin domain-containing protein 1(gene name synonym)|uniprotkb:Farp1(gene name)|psi-mi:Farp1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000025555(gene)|ensembl:ENSMUST00000026635(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007416"(synapse assembly)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035899|interpro:IPR035963|interpro:IPR041788|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9035034|refseq:NP_598843.3|refseq:XP_006518977.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:FF1E2m+C2jrf4rDejtDV2rn93GA10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8BWY3	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-8737530|uniprotkb:Q3TPZ6|uniprotkb:Q91VH9|ensembl:ENSMUSP00000025218	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:erf1_mouse(display_long)|uniprotkb:Etf1(gene name)|psi-mi:Etf1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_659115.3|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003747"(translation release factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006415"(translational termination)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0006479"(protein methylation)|go:"GO:0008079"(translation termination factor activity)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|rcsb pdb:5DMQ|rcsb pdb:5DMR|reactome:R-MMU-72764|reactome:R-MMU-975956|reactome:R-MMU-975957|ensembl:ENSMUSG00000024360(gene)|ensembl:ENSMUST00000025218(transcript)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:vUI2Eq2wx++5VxZ2MK1EQ0jnWMI10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q6PH08	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-16726089|ensembl:ENSMUSP00000147886|uniprotkb:Q80U20|uniprotkb:Q8CCP1	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:erc2_mouse(display_long)|uniprotkb:CAZ-associated structural protein 1(gene name synonym)|uniprotkb:Erc2(gene name)|psi-mi:Erc2(display_short)|uniprotkb:Cast1(gene name synonym)|uniprotkb:D14Ertd171e(gene name synonym)|uniprotkb:Kiaa0378(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000040640(gene)|ensembl:ENSMUST00000211145(transcript)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048790"(maintenance of presynaptic active zone structure)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|interpro:IPR019323|interpro:IPR030625|refseq:NP_808482.2|refseq:XP_006519013.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:bmubXKmJ7vf/Hxo37UGDaxgYamM10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9WV92	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-911885|uniprotkb:Q69ZT8|ensembl:ENSMUSP00000079098|uniprotkb:Q9R102	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:e41l3_mouse(display_long)|uniprotkb:4.1B(gene name synonym)|uniprotkb:Differentially expressed in adenocarcinoma of the lung protein 1(gene name synonym)|uniprotkb:Epb41l3(gene name)|psi-mi:Epb41l3(display_short)|uniprotkb:Dal1(gene name synonym)|uniprotkb:Epb4.1l3(gene name synonym)|uniprotkb:Kiaa0987(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000024044(gene)|ensembl:ENSMUST00000080208(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043217"(myelin maintenance)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030691|interpro:IPR035963|mint:Q9WV92|reactome:R-MMU-6794361|refseq:NP_038841.1|refseq:XP_011244586.1|refseq:XP_011244591.1|refseq:XP_017172724.1|refseq:XP_017172725.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:51gkxiswTUqQbAUqjGoPthWD7jM10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9Z2H5	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-774482|uniprotkb:Q3U3L1|uniprotkb:Q3UHP7|uniprotkb:Q80U34|uniprotkb:Q8K204	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:e41l1_mouse(display_long)|uniprotkb:Neuronal protein 4.1(gene name synonym)|uniprotkb:Epb41l1(gene name)|psi-mi:Epb41l1(display_short)|uniprotkb:Epb4(gene name synonym)|uniprotkb:Epb4.1l1(gene name synonym)|uniprotkb:Kiaa0338(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001278049.1|refseq:NP_001278051.1|refseq:NP_001278052.1|refseq:NP_001006665.1|refseq:NP_038538.1|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR019749|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019747|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR018979|interpro:IPR018980|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR007477(SAB)|interpro:IPR029071|interpro:IPR035963|mint:Q9Z2H5|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0097060"(synaptic membrane)|reactome:R-MMU-399719|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:Lu31NnWhI356njHUtKbBlaO6nWE10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P62631	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-642385|uniprotkb:P27706|ensembl:ENSMUSP00000054556	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ef1a2_mouse(display_long)|uniprotkb:Eukaryotic elongation factor 1 A-2(gene name synonym)|uniprotkb:Statin-S1(gene name synonym)|uniprotkb:Eef1a2(gene name)|psi-mi:Eef1a2(display_short)|uniprotkb:Eef1al(gene name synonym)|uniprotkb:Stn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_031932.1|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0090218"(positive regulation of lipid kinase activity)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P62631|ensembl:ENSMUSG00000016349(gene)|ensembl:ENSMUST00000055990(transcript)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:5Wr8A9JfvVaH+KRGc6VSnF2rkYE10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9JHU4	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-645061|uniprotkb:E9QM71|ensembl:ENSMUSP00000018851	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dyhc1_mouse(display_long)|uniprotkb:Dhc1(gene name synonym)|uniprotkb:Dyhc(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:Dync1h1(gene name)|psi-mi:Dync1h1(display_short)|uniprotkb:Dnch1(gene name synonym)|uniprotkb:Dnchc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_084514.2|ensembl:ENSMUSG00000018707(gene)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002177"(manchette)|go:"GO:0003341"(cilium movement)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|ensembl:ENSMUST00000018851(transcript)|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|interpro:IPR042219|mint:Q9JHU4|rcsb pdb:3ERR|rcsb pdb:3J1T|rcsb pdb:3J1U|rcsb pdb:3WUQ|rcsb pdb:5AYH|rcsb pdb:6RZA|rcsb pdb:6RZB|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:sbED0xqQpe32T7I8ijeS3Xqlx7010090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9R0P5	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-1184008|ensembl:ENSMUSP00000099461	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dest_mouse(display_long)|uniprotkb:Dstn(gene name)|psi-mi:Dstn(display_short)|uniprotkb:Dsn(gene name synonym)|uniprotkb:Sid23(gene name synonym)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Sid 23(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_062745.1|ensembl:ENSMUSG00000015932(gene)|ensembl:ENSMUST00000103172(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR029006|interpro:IPR029924|mint:Q9R0P5	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:hqPae8VWEKvGPITqHtrSs78yI4M10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:O35098	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-773225|uniprotkb:O08886|uniprotkb:Q3UL94	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dpyl4_mouse(display_long)|uniprotkb:Collapsin response mediator protein 3(gene name synonym)|uniprotkb:UNC33-like phosphoprotein 4(gene name synonym)|uniprotkb:Dpysl4(gene name)|psi-mi:Dpysl4(display_short)|uniprotkb:Crmp3(gene name synonym)|uniprotkb:Ulip4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	interpro:IPR030612|interpro:IPR032466|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011778(D-hydantoinase)|interpro:IPR011059(Metal-dependent hydrolase, composite)|mint:O35098|go:"GO:0005737"(cytoplasm)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0031005"(filamin binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070997"(neuron death)|go:"GO:0097485"(neuron projection guidance)|reactome:R-MMU-399956	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:OUbDfG6PnA7vEdKa4RKXK2cprCk10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:O08553	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-446064|uniprotkb:Q6P5D0|ensembl:ENSMUSP00000022629	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dpyl2_mouse(display_long)|uniprotkb:Unc-33-like phosphoprotein 2(gene name synonym)|uniprotkb:Dpysl2(gene name)|psi-mi:Dpysl2(display_short)|uniprotkb:Crmp2(gene name synonym)|uniprotkb:Ulip2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_034085.2|ensembl:ENSMUSG00000022048(gene)|ensembl:ENSMUST00000022629(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043209"(myelin sheath)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098793"(presynapse)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030615|interpro:IPR032466|mint:O08553|rcsb pdb:5UQC|reactome:R-MMU-399956|reactome:R-MMU-437239	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:97yc8TNEPMcGtGNRLvl+KV+DYr010090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8BZ98	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-6880033|uniprotkb:B2RUH0|uniprotkb:Q3UGY9|uniprotkb:Q80TR2|uniprotkb:Q8BWW6	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dyn3_mouse(display_long)|uniprotkb:Dnm3(gene name)|psi-mi:Dnm3(display_short)|uniprotkb:Kiaa0820(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	interpro:IPR030381|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0045202"(synapse)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|reactome:R-MMU-166016|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|interpro:IPR022812|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR019762|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR020850|interpro:IPR027417|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|refseq:NP_001033708.1|refseq:NP_766234.1|mint:Q8BZ98	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:xypgFOdNeEf2OIWkIVcxIKiT80Y10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P39054	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-642337|uniprotkb:Q9DBE1|ensembl:ENSMUSP00000133564	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dyn2_mouse(display_long)|uniprotkb:Dynamin UDNM(gene name synonym)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001240822.1|refseq:NP_001240823.1|refseq:NP_031897.2|ensembl:ENSMUSG00000033335(gene)|ensembl:ENSMUST00000172482(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008017"(microtubule binding)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061025"(membrane fusion)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035904"(aorta development)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P39054|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-203641|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-437239|reactome:R-MMU-8856828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:+f91mVsvYvuhsUOSzw37RpZv/2M10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8K1M6	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-2365792|uniprotkb:Q8BNQ5|uniprotkb:Q8BQ64|uniprotkb:Q8CGD0|uniprotkb:Q8K1A1	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dnm1l_mouse(display_long)|uniprotkb:Dnm1l(gene name)|psi-mi:Dnm1l(display_short)|uniprotkb:Drp1(gene name synonym)|uniprotkb:Dynamin-related protein 1(gene name synonym)|uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001021118.1|refseq:XP_006522694.1|refseq:NP_001263269.1|refseq:NP_001263270.1|refseq:NP_690029.2|dip:DIP-54818N|mint:Q8K1M6|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016020"(membrane)|go:"GO:0016559"(peroxisome fission)|go:"GO:0030276"(clathrin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036466"(synaptic vesicle recycling via endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048511"(rhythmic process)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051433"(BH2 domain binding)|go:"GO:0060047"(heart contraction)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070266"(necroptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090149"(mitochondrial membrane fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099503"(secretory vesicle)|go:"GO:1900063"(regulation of peroxisome organization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903578"(regulation of ATP metabolic process)|go:"GO:1904579"(cellular response to thapsigargin)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:1905395"(response to flavonoid)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR030556|reactome:R-MMU-75153|go:"GO:0005903"(brush border)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:5yGX3+QNfz3+dKRHA2ffkIVq3yU10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P39053	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-397785|ensembl:ENSMUSP00000122679|uniprotkb:A2AN50|uniprotkb:A2AN51|uniprotkb:A2AN54|uniprotkb:A2AN55|uniprotkb:Q3UNM1|uniprotkb:Q5DTN7|uniprotkb:Q61358|uniprotkb:Q61359|uniprotkb:Q61360|uniprotkb:Q6PDM5|uniprotkb:Q8JZZ4|uniprotkb:Q9CSY7|uniprotkb:Q9QXX1	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dyn1_mouse(display_long)|uniprotkb:Dnm1(gene name)|psi-mi:Dnm1(display_short)|uniprotkb:Dnm(gene name synonym)|uniprotkb:Kiaa4093(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_034195.2|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:P39053|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|ensembl:ENSMUSG00000026825(gene)|ensembl:ENSMUST00000139624(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904645"(response to amyloid-beta)|refseq:NP_001288666.1|refseq:XP_006497721.2|refseq:XP_006497722.2|refseq:XP_006497723.2|refseq:XP_006497724.2|refseq:XP_006497718.2|refseq:XP_017170817.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:wtPz3gwyxU6tAgh5091LQpt099I10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q80TZ3	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-773072|uniprotkb:Q6P2K9|uniprotkb:Q8C7L9|uniprotkb:B1B0B9|ensembl:ENSMUSP00000044251	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:auxi_mouse(display_long)|uniprotkb:DnaJ homolog subfamily C member 6(gene name synonym)|uniprotkb:Dnajc6(gene name)|psi-mi:Dnajc6(display_short)|uniprotkb:Kiaa0473(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001158055.1|refseq:NP_001158056.1|refseq:NP_001158057.1|refseq:NP_940804.1|refseq:XP_017175882.1|ensembl:ENSMUSG00000028528(gene)|ensembl:ENSMUST00000038207(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098793"(presynapse)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|interpro:IPR036869|mint:Q80TZ3|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-8856828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:5GFmotNm8YcyPXpIr1cCVmXQ+Jw10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q62108	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q91XM9	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-400138|uniprotkb:Q8BXK7|uniprotkb:Q8BYG5|ensembl:ENSMUSP00000102814|uniprotkb:F8VQM7	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dlg2_mouse(display_long)|uniprotkb:Dlg2(gene name)|psi-mi:Dlg2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000052572(gene)|ensembl:ENSMUST00000107196(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035759|interpro:IPR036028|interpro:IPR036034|mint:Q91XM9|rcsb pdb:2WL7|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6794361|refseq:NP_001229976.1|refseq:NP_035937.2|dip:DIP-31569N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:37/IFbjDNxh87dnN2gglIgDGyIU10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:O08788	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-776180|uniprotkb:E9QLJ1|uniprotkb:Q3TZG7|ensembl:ENSMUSP00000109552	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dctn1_mouse(display_long)|uniprotkb:150 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:DAP-150(gene name synonym)|uniprotkb:p150-glued(gene name synonym)|uniprotkb:Dctn1(gene name)|psi-mi:Dctn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_031861.2|dip:DIP-32057N|ensembl:ENSMUSG00000031865(gene)|ensembl:ENSMUST00000113919(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005938"(cell cortex)|go:"GO:0007097"(nuclear migration)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032402"(melanosome transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045171"(intercellular bridge)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061744"(motor behavior)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0099738"(cell cortex region)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1904398"(positive regulation of neuromuscular junction development)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR022157|interpro:IPR036859|mint:O08788|reactome:R-MMU-2132295|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-8854518	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:pqj7TtNDgexEbxqLwksW3eW41bo10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9JLM8	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-771719|uniprotkb:Q6P207|ensembl:ENSMUSP00000050034	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dclk1_mouse(display_long)|uniprotkb:Doublecortin-like and CAM kinase-like 1(gene name synonym)|uniprotkb:Dclk1(gene name)|psi-mi:Dclk1(display_short)|uniprotkb:Dclk(gene name synonym)|uniprotkb:Dcamkl1(gene name synonym)|uniprotkb:Doublecortin-like kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_064362.1|ensembl:ENSMUSG00000027797(gene)|ensembl:ENSMUST00000054237(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0009615"(response to virus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030900"(forebrain development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003533(Doublecortin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036572|mint:Q9JLM8	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:P3ZZ2GyKcdMimAcekZ8OlLbuciM10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9QXS6	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-445208|uniprotkb:A2CG16|uniprotkb:Q3V234|uniprotkb:Q922X1|uniprotkb:Q9QXS5|ensembl:ENSMUSP00000021950	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dreb_mouse(display_long)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:Dbn1(gene name)|psi-mi:Dbn1(display_short)|uniprotkb:Drba(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001170842.1|refseq:NP_001170843.1|refseq:NP_062787.2|ensembl:ENSMUSG00000034675(gene)|ensembl:ENSMUST00000021950(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0005856"(cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048699"(generation of neurons)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0098828"(modulation of inhibitory postsynaptic potential)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:1904113"(negative regulation of muscle filament sliding)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q9QXS6|reactome:R-MMU-9013405|reactome:R-MMU-9013407|reactome:R-MMU-9013418|reactome:R-MMU-9013422	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:ArZUGZNIUfSwoIketPcPCXlSM8410090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q5SQX6	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9JLV5	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-2551335|ensembl:ENSMUSP00000130738	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:cul3_mouse(display_long)|uniprotkb:Cul3(gene name)|psi-mi:Cul3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000004364(gene)|ensembl:ENSMUST00000163119(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q9JLV5|rcsb pdb:1IUY|reactome:R-MMU-4641258|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-8932339|reactome:R-MMU-8951664|go:"GO:0030030"(cell projection organization)|reactome:R-MMU-9013418|reactome:R-MMU-9013422|reactome:R-MMU-9706019|reactome:R-MMU-983168|refseq:NP_057925.1|refseq:NP_001300657.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:tSFsLPpnn80evlnxKTXO5olW5Xg10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P97427	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-773110|uniprotkb:O08554|uniprotkb:O35097|ensembl:ENSMUSP00000031004	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:dpyl1_mouse(display_long)|uniprotkb:Collapsin response mediator protein 1(gene name synonym)|uniprotkb:Unc-33-like phosphoprotein 3(gene name synonym)|uniprotkb:Crmp1(gene name)|psi-mi:Crmp1(display_short)|uniprotkb:Dpysl1(gene name synonym)|uniprotkb:Ulip3(gene name synonym)|uniprotkb:Inactive dihydropyrimidinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_031791.3|ensembl:ENSMUSG00000029121(gene)|ensembl:ENSMUST00000031004(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007411"(axon guidance)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031005"(filamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1904530"(negative regulation of actin filament binding)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030624|interpro:IPR032466|mint:P97427|rcsb pdb:1KCX|reactome:R-MMU-399956	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:/fpPxm3SNtnLKjXWrWOuG0QO3Nk10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:O54991	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-774794|uniprotkb:A2A4K6|ensembl:ENSMUSP00000099398	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:cntp1_mouse(display_long)|uniprotkb:Neurexin-4(gene name synonym)|uniprotkb:Neurexin IV(gene name synonym)|uniprotkb:Paranodin(gene name synonym)|uniprotkb:NCP1(gene name synonym)|uniprotkb:MHDNIV(gene name synonym)|uniprotkb:Cntnap1(gene name)|psi-mi:Cntnap1(display_short)|uniprotkb:Nrxn4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_058062.2|ensembl:ENSMUSG00000017167(gene)|ensembl:ENSMUST00000103109(transcript)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0005886"(plasma membrane)|go:"GO:0005918"(septate junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030424"(axon)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0033010"(paranodal junction)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR028872|interpro:IPR036056|mint:O54991	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:BTW+FjgSUq00WpWGDC6PpQcIowE10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P80318	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-772361|ensembl:ENSMUSP00000001452	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:tcpg_mouse(display_long)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:Matricin(gene name synonym)|uniprotkb:mTRiC-P5(gene name synonym)|uniprotkb:Cct3(gene name)|psi-mi:Cct3(display_short)|uniprotkb:Cctg(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_033966.1|dip:DIP-32344N|ensembl:ENSMUSG00000001416(gene)|ensembl:ENSMUST00000001452(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P80318|rcsb pdb:1GML|rcsb pdb:1GN1|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6814122	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:+jrWcoDzrkHivHA/h3aApt0gBFU10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P47754	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-299188|ensembl:ENSMUSP00000015877	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:caza2_mouse(display_long)|uniprotkb:Capza2(gene name)|psi-mi:Capza2(display_short)|uniprotkb:Cappa2(gene name synonym)|uniprotkb:CapZ alpha-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUST00000015877(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P47754|reactome:R-MMU-2132295|reactome:R-MMU-3371497|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-879415|reactome:R-MMU-983231|ensembl:ENSMUSG00000015733(gene)|refseq:NP_031630.1|dip:DIP-31382N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:9nxfEbrpHlDtTYwSvHAJvZLLweo10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q3UHL1	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-771778|uniprotkb:Q8VD20|ensembl:ENSMUSP00000040430	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:camkv_mouse(display_long)|uniprotkb:Camkv(gene name)|psi-mi:Camkv(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_663596.1|refseq:XP_006511785.1|ensembl:ENSMUSG00000032936(gene)|ensembl:ENSMUST00000035700(transcript)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|mint:Q3UHL1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:MJKDl/5XBCLsNw3CrNkwzC9zqYI10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P28652	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P11798	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8BKX1	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P59999	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-445034|uniprotkb:O15509|uniprotkb:Q3UWV4|ensembl:ENSMUSP00000114839	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:arpc4_mouse(display_long)|uniprotkb:Arp2/3 complex 20 kDa subunit(gene name synonym)|uniprotkb:Arpc4(gene name)|psi-mi:Arpc4(display_short)|uniprotkb:Arc20(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001163956.1|refseq:NP_001163957.1|refseq:NP_080828.1|ensembl:ENSMUSG00000079426(gene)|ensembl:ENSMUST00000156898(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0051015"(actin filament binding)|interpro:IPR008384(ARP23 complex 20 kDa subunit)|interpro:IPR034666|mint:P59999|rcsb pdb:7AQK|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-5663213|reactome:R-MMU-8856828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:Iqe60TWfO3QBVOY+fOqZd9JWfIE10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q60875	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-772191|uniprotkb:E9QNW9|uniprotkb:O09115|uniprotkb:Q3TBI4|uniprotkb:Q3TJ16|uniprotkb:Q8CHE1|uniprotkb:Q923E0|uniprotkb:Q9ESG7|ensembl:ENSMUSP00000029694	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:arhg2_mouse(display_long)|uniprotkb:Kiaa0651(gene name synonym)|uniprotkb:Lbcl1(gene name synonym)|uniprotkb:Lfc(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Lymphoid blast crisis-like 1(gene name synonym)|uniprotkb:LBC'S first cousin(gene name synonym)|uniprotkb:Oncogene LFC(gene name synonym)|uniprotkb:Rhobin(gene name synonym)|uniprotkb:Arhgef2(gene name)|psi-mi:Arhgef2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001185840.1|refseq:NP_001185841.1|refseq:NP_001185842.1|refseq:NP_032513.3|refseq:XP_006501130.1|ensembl:ENSMUSG00000028059(gene)|ensembl:ENSMUST00000029694(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002102"(podosome)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071802"(negative regulation of podosome assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037806|interpro:IPR041020|mint:Q60875|rcsb pdb:5WI4|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:Le4PMm1AT/ManVpetNT2wBsUlok10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P61205	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-444797|uniprotkb:P16587|ensembl:ENSMUSP00000050689	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:arf3_mouse(display_long)|uniprotkb:Arf3(gene name)|psi-mi:Arf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_031504.1|refseq:XP_011243747.1|ensembl:ENSMUSG00000051853(gene)|ensembl:ENSMUST00000053183(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P61205|reactome:R-MMU-1660514|reactome:R-MMU-6807878|reactome:R-MMU-6811434	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:np09WjdbXRu9vgMbiXn9EA3ExqA10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9DBG3	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-775229|uniprotkb:Q80XJ4|ensembl:ENSMUSP00000070714	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ap2b1_mouse(display_long)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:Ap2b1(gene name)|psi-mi:Ap2b1(display_short)|uniprotkb:Clapb1(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001030931.1|refseq:NP_082191.1|refseq:XP_006534321.1|refseq:XP_017170261.1|dip:DIP-32161N|ensembl:ENSMUSG00000035152(gene)|ensembl:ENSMUST00000065692(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0035904"(aorta development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q9DBG3|rcsb pdb:6OWO|rcsb pdb:6OXL|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:YWwOqRpXCJDwzrLv27muBx1+DHI10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P17426	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-775189|ensembl:ENSMUSP00000082519|ensembl:ENSMUSP00000127842	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ap2a1_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Ap2a1(gene name)|psi-mi:Ap2a1(display_short)|uniprotkb:Adtaa(gene name synonym)|uniprotkb:Clapa1(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001070732.1|refseq:NP_031484.1|ensembl:ENSMUSG00000060279(gene)|ensembl:ENSMUST00000085399(transcript)|ensembl:ENSMUST00000166972(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0032433"(filopodium tip)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:P17426|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:Dd6Q+Et/LTlmo5qpro2Zaeq0dMc10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P61967	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-516247|uniprotkb:P82267|uniprotkb:Q00382|uniprotkb:Q9BTN4|uniprotkb:Q9UDW9|ensembl:ENSMUSP00000106709	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ap1s1_mouse(display_long)|uniprotkb:Sigma-adaptin 1A(gene name synonym)|uniprotkb:Sigma1A-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin sigma-1A subunit(gene name synonym)|uniprotkb:HA1 19 kDa subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 sigma-1A small chain(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP19(gene name synonym)|uniprotkb:Sigma 1a subunit of AP-1 clathrin(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit sigma-1A(gene name synonym)|uniprotkb:Ap1s1(gene name)|psi-mi:Ap1s1(display_short)|uniprotkb:Ap19(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit sigma-1A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000004849(gene)|ensembl:ENSMUST00000111080(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|refseq:NP_031483.1|interpro:IPR022775|interpro:IPR044733|reactome:R-MMU-432722|rcsb pdb:1W63|reactome:R-MMU-2132295|reactome:R-MMU-432720	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:2lE9ZcVbrYANDaYhT4mLYzppefA10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:O35643	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-348937|uniprotkb:Q3TXG4|uniprotkb:Q922E2|ensembl:ENSMUSP00000009234	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ap1b1_mouse(display_long)|uniprotkb:Ap1b1(gene name)|psi-mi:Ap1b1(display_short)|uniprotkb:Adtb1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_031480.2|ensembl:ENSMUSG00000009090(gene)|ensembl:ENSMUST00000009234(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048268"(clathrin coat assembly)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:zTEB4qq5OQCyxOOnVs9OeWAQBqA10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q99NH0	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-647840|uniprotkb:Q3TV99|uniprotkb:Q5F4T7|uniprotkb:Q6PG69|uniprotkb:Q6ZQ66|uniprotkb:Q8CHT4|ensembl:ENSMUSP00000014421	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:anr17_mouse(display_long)|uniprotkb:Foe(gene name synonym)|uniprotkb:Kiaa0697(gene name synonym)|uniprotkb:Gene trap ankyrin repeat protein(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein FOE(gene name synonym)|uniprotkb:Ankrd17(gene name)|psi-mi:Ankrd17(display_short)|uniprotkb:Gtar(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_112148.2|ensembl:ENSMUSG00000055204(gene)|ensembl:ENSMUST00000014421(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007492"(endoderm development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|mint:Q99NH0	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:c/59Xwrg6uFRRx34dzmzkER9Lik10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8C8R3	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-774322|intact:EBI-2133064|uniprotkb:Q6PCN2|uniprotkb:Q3TM62|uniprotkb:Q3V2X0|uniprotkb:Q80ZZ7|uniprotkb:Q8BNC1|uniprotkb:Q8C445|uniprotkb:Q8CCV0|intact:EBI-2255612|intact:EBI-8314005|intact:MINT-4115219	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:ank2_mouse(display_long)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:AnkB(gene name synonym)|uniprotkb:Ank2(gene name)|psi-mi:Ank2(display_short)|uniprotkb:Ankyrin-B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001029340.1|refseq:NP_848770.2|dip:DIP-58645N|mint:Q8C8R3|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001257"(regulation of cation channel activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:SkB13oxZVcKuMnI8r5ItFIq2pXQ10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q3UHD9	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-771911|uniprotkb:Q5DU45|ensembl:ENSMUSP00000043466	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:agap2_mouse(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Kiaa0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001028435.1|refseq:NP_001287943.1|ensembl:ENSMUSG00000025422(gene)|ensembl:ENSMUST00000039259(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|go:"GO:0005768"(endosome)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:yq2lQtfk+FPqgT++CxAx2CS69nE10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:P60710	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-353957|ensembl:ENSMUSP00000098066|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q3TI89|uniprotkb:Q3TVP6|uniprotkb:Q64316|uniprotkb:Q6ZWM3	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:actb_mouse(display_long)|uniprotkb:Actb(gene name)|psi-mi:Actb(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	ensembl:ENSMUSG00000029580(gene)|ensembl:ENSMUST00000100497(transcript)|refseq:NP_031419.1|go:"GO:0002102"(podosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60710|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5250924|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-5689603|reactome:R-MMU-5696394|reactome:R-MMU-8856828|reactome:R-MMU-9035034|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0070160"(tight junction)|go:"GO:0001725"(stress fiber)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|dip:DIP-31574N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q8CBW3	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q3UHJ0	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-771618|uniprotkb:B2RUJ0|uniprotkb:Q3TY53|uniprotkb:Q6ZPZ6|uniprotkb:Q80XP6|ensembl:ENSMUSP00000086948	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:aak1_mouse(display_long)|uniprotkb:Adaptor-associated kinase 1(gene name synonym)|uniprotkb:Aak1(gene name)|psi-mi:Aak1(display_short)|uniprotkb:Kiaa1048(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_001035195.1|refseq:NP_808430.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030136"(clathrin-coated vesicle)|ensembl:ENSMUSG00000057230(gene)|ensembl:ENSMUST00000089519(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0071439"(clathrin complex)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q3UHJ0|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:VdUCkCmofdJSa676n0jLS8VLDso10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9WV60	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-400793|ensembl:ENSMUSP00000023507	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:gsk3b_mouse(display_long)|uniprotkb:Gsk3b(gene name)|psi-mi:Gsk3b(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_062801.1|dip:DIP-32446N|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006983"(ER overload response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014043"(negative regulation of neuron maturation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034452"(dynactin binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:Q9WV60|rcsb pdb:4NU1|rcsb pdb:5AIR|rcsb pdb:6AE3|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3371453|reactome:R-MMU-399956|reactome:R-MMU-4641262|reactome:R-MMU-5250924|reactome:R-MMU-5610785|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046849"(bone remodeling)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0106027"(neuron projection organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904780"(negative regulation of protein localization to centrosome)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|ensembl:ENSMUSG00000022812(gene)|ensembl:ENSMUST00000023507(transcript)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:FKe0WkOBBYU0vIJLmcFNMJ+KVHA10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMB8	uniprotkb:Q9QYS2	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	intact:EBI-770623|uniprotkb:Q14DJ9|ensembl:ENSMUSP00000004076	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:grm3_mouse(display_long)|uniprotkb:Gprc1c(gene name synonym)|uniprotkb:Mglur3(gene name synonym)|uniprotkb:Grm3(gene name)|psi-mi:Grm3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727444|imex:IM-26285-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_862898.1|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0010467"(gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|ensembl:ENSMUSG00000003974(gene)|ensembl:ENSMUST00000004076(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001234(GPCR, family 3, metabotropic glutamate receptor 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:Q9QYS2|reactome:R-MMU-418594|reactome:R-MMU-420499	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rogid:6YCf0CVHHO8OR8GpAMxCucRLxJE10090	rigid:scZiTaFPdzgz/rLDuBkAagTn3s4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q7TPH6	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q64514	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-8317775|intact:MINT-4138337|uniprotkb:Q5D072|ensembl:ENSMUSP00000085244	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:tpp2_mouse(display_long)|uniprotkb:Tpp2(gene name)|psi-mi:Tpp2(display_short)|uniprotkb:Tripeptidyl-peptidase II(gene name synonym)|uniprotkb:Tripeptidyl aminopeptidase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_001297469.1|refseq:NP_033444.1|ensembl:ENSMUSG00000041763(gene)|ensembl:ENSMUST00000087933(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008240"(tripeptidyl-peptidase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR022229|interpro:IPR022398|interpro:IPR023828|interpro:IPR034051|interpro:IPR036852|mint:Q64514|reactome:R-MMU-983168	-	-	comment:mint|function:Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:tplIdWcjyJniZm5rvcnivHk8ztQ10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:P83510	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	-	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q4ACU6	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:D3YZU1	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-2314988|ensembl:ENSMUSP00000103571	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:shan1_mouse(display_long)|uniprotkb:Shank1(gene name)|psi-mi:Shank1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_001029287.1|refseq:XP_006540927.1|ensembl:ENSMUSG00000038738(gene)|ensembl:ENSMUST00000107938(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:TbxBmjjabypLqTlAx9zbkSAAzpk10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q8BYM5	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-775074|uniprotkb:A2AGI1|uniprotkb:Q8BXR4|ensembl:ENSMUSP00000066304	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:nlgn3_mouse(display_long)|uniprotkb:Gliotactin homolog(gene name synonym)|uniprotkb:Nlgn3(gene name)|psi-mi:Nlgn3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_766520.2|ensembl:ENSMUSG00000031302(gene)|ensembl:ENSMUST00000065858(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030024|mint:Q8BYM5|rcsb pdb:7CEE|rcsb pdb:7CEG|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:Gw7lb80nZihiPKBscpj115Zsldo10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q62108	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q7TMB8	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:P17426	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-775189|ensembl:ENSMUSP00000082519|ensembl:ENSMUSP00000127842	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:ap2a1_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Ap2a1(gene name)|psi-mi:Ap2a1(display_short)|uniprotkb:Adtaa(gene name synonym)|uniprotkb:Clapa1(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_001070732.1|refseq:NP_031484.1|ensembl:ENSMUSG00000060279(gene)|ensembl:ENSMUST00000085399(transcript)|ensembl:ENSMUST00000166972(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0032433"(filopodium tip)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:P17426|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:Dd6Q+Et/LTlmo5qpro2Zaeq0dMc10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q8CBW3	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q8R5H6	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-774719|uniprotkb:Q91W51|uniprotkb:Q9ERQ9|ensembl:ENSMUSP00000019975|ensembl:ENSMUSP00000101148	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:wasf1_mouse(display_long)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Wasf1(gene name)|psi-mi:Wasf1(display_short)|uniprotkb:Wave1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_114083.1|refseq:XP_006512995.1|ensembl:ENSMUSG00000019831(gene)|ensembl:ENSMUST00000019975(transcript)|ensembl:ENSMUST00000105509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8R5H6|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:t+4F2ap7lNjE/AGuIwMhel4YknU10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q812A2	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-2013018|uniprotkb:Q80U09|uniprotkb:Q8BKP4|uniprotkb:Q8BLD0|uniprotkb:Q925I2	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:srgp3_mouse(display_long)|uniprotkb:Srgap3(gene name)|psi-mi:Srgap3(display_short)|uniprotkb:Arhgap14(gene name synonym)|uniprotkb:Kiaa0411(gene name synonym)|uniprotkb:Srgap2(gene name synonym)|uniprotkb:WAVE-associated Rac GTPase-activating protein(gene name synonym)|uniprotkb:Rho GTPase-activating protein 14(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	interpro:IPR031160|refseq:NP_536696.4|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|mint:Q812A2|interpro:IPR035648|interpro:IPR036028|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0030336"(negative regulation of cell migration)|reactome:R-MMU-9013148|reactome:R-MMU-9013149	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:rfo/ZKi//Gub/088qDvqLIvgdng10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q68FG2	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-2255511|ensembl:ENSMUSP00000008991	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:q68fg2_mouse(display_long)|uniprotkb:Sptbn2(gene name)|psi-mi:Sptbn2(display_short)|uniprotkb:Spnb3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_067262.1|refseq:XP_006531767.1|refseq:XP_006531768.1|ensembl:ENSMUSG00000067889(gene)|ensembl:ENSMUST00000008991(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008091"(spectrin)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0030534"(adult behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051693"(actin filament capping)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098918"(structural constituent of synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:0099189"(postsynaptic spectrin-associated cytoskeleton)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-MMU-2132295|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:2F7U0dl21KxXpc9Z2sk7D/wzQvM10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q62261	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:P16546	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-911063|uniprotkb:A3KGU6|uniprotkb:Q8K380|uniprotkb:Q9CT05|uniprotkb:A3KGU8|ensembl:ENSMUSP00000092697	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:sptn1_mouse(display_long)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym)|uniprotkb:Spta2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	dip:DIP-37712N|ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000095083(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032437"(cuticular plate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:P16546|reactome:R-MMU-264870|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:UVB6Kv+PBlqDH3OLoGjxm5oYVPQ10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:A2AQ25	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-8821027|ensembl:ENSMUSP00000066170|uniprotkb:A2AUE9|uniprotkb:A2AUF0|uniprotkb:A2AUF1|uniprotkb:Q75UV8|uniprotkb:Q75UV9|uniprotkb:Q80VK2|uniprotkb:Q8BHX8|uniprotkb:Q8BHY1|uniprotkb:Q8CHA8|uniprotkb:Q8R0K6	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:skt_mouse(display_long)|uniprotkb:Skt(gene name)|psi-mi:Skt(display_short)|uniprotkb:Etl4(gene name synonym)|uniprotkb:Kiaa1217(gene name synonym)|uniprotkb:Enhancer trap locus 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	interpro:IPR022782|interpro:IPR026725|mint:A2AQ25|ensembl:ENSMUSG00000036617(gene)|ensembl:ENSMUST00000066509(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0048706"(embryonic skeletal system development)|refseq:NP_001074475.1|refseq:NP_001171101.2|refseq:NP_084171.2|refseq:NP_835160.2|refseq:XP_006497478.1|refseq:XP_006497487.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:WI45C2F/GFoa1PhVnBHPtxCj5mM10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q8C437	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:B1AXH1	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-16727856|ensembl:ENSMUSP00000098893|uniprotkb:E9Q0V6	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:nhsl2_mouse(display_long)|uniprotkb:Nhsl2(gene name)|psi-mi:Nhsl2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_001157082.1|ensembl:ENSMUSG00000079481(gene)|ensembl:ENSMUST00000101339(transcript)|go:"GO:0030154"(cell differentiation)|interpro:IPR024845	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:DXMtK3V/Y2AHNoZgtG8OqaERroA10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q8K1R7	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-2553319|uniprotkb:Q148U2|ensembl:ENSMUSP00000049056|uniprotkb:Q8R3P1	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:nek9_mouse(display_long)|uniprotkb:Nek9(gene name)|psi-mi:Nek9(display_short)|uniprotkb:Nercc(gene name synonym)|uniprotkb:Never in mitosis A-related kinase 9(gene name synonym)|uniprotkb:Nercc1 kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	ensembl:ENSMUSG00000034290(gene)|ensembl:ENSMUST00000040992(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007049"(cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011009(Protein kinase-like)|interpro:IPR042767|mint:Q8K1R7|rcsb pdb:5DE2|reactome:R-MMU-2980767|refseq:NP_660120.2|dip:DIP-56880N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:HVtKV0f4KRYqJ5BTuVohMgrJS6A10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:P28660	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q99104	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-400199|uniprotkb:E9PUE5|ensembl:ENSMUSP00000116028	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:myo5a_mouse(display_long)|uniprotkb:Myo5a(gene name)|psi-mi:Myo5a(display_short)|uniprotkb:Dilute(gene name synonym)|uniprotkb:Dilute myosin heavy chain, non-muscle(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_034994.2|ensembl:ENSMUSG00000034593(gene)|ensembl:ENSMUST00000123128(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000149"(SNARE binding)|go:"GO:0001726"(ruffle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007601"(visual perception)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014046"(dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031585"(regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031982"(vesicle)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032433"(filopodium tip)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042476"(odontogenesis)|go:"GO:0042552"(myelination)|go:"GO:0042641"(actomyosin)|go:"GO:0042642"(actomyosin, myosin complex part)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043473"(pigmentation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0050808"(synapse organization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051643"(endoplasmic reticulum localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099089"(establishment of endoplasmic reticulum localization to postsynapse)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0099640"(axo-dendritic protein transport)|go:"GO:0150103"(reactive gliosis)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|go:"GO:0030318"(melanocyte differentiation)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR037988|mint:Q99104|rcsb pdb:2IX7|rcsb pdb:3WB8|rcsb pdb:4KP3|rcsb pdb:4ZLK|rcsb pdb:6KU0|reactome:R-MMU-2029482|interpro:IPR002710(Dilute)|go:"GO:0030141"(secretory granule)|dip:DIP-29542N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:8QtBlLL4DqB3An4CoCFVmvBEXBg10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:O35099	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q08460	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:P46660	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-400482|uniprotkb:Q61958|uniprotkb:Q8VCW5|ensembl:ENSMUSP00000041347	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:ainx_mouse(display_long)|uniprotkb:Ina(gene name)|psi-mi:Ina(display_short)|uniprotkb:66 kDa neurofilament protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_666212.3|ensembl:ENSMUSG00000034336(gene)|ensembl:ENSMUST00000037636(transcript)|go:"GO:0005883"(neurofilament)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027703|interpro:IPR039008|mint:P46660	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:amjP0AajB8s2oXmV96wzyfz6evE10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q8VDC1	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-16727814|ensembl:ENSMUSP00000081764|ensembl:ENSMUSP00000133222|uniprotkb:Q3V385|uniprotkb:Q7TMT0|uniprotkb:Q8BJN2	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:fyco1_mouse(display_long)|uniprotkb:Fyco1(gene name)|psi-mi:Fyco1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	ensembl:ENSMUSG00000025241(gene)|ensembl:ENSMUST00000084715(transcript)|ensembl:ENSMUST00000167595(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0072383"(plus-end-directed vesicle transport along microtubule)|go:"GO:1901098"(positive regulation of autophagosome maturation)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR004012(RUN)|interpro:IPR009038(GOLD)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR036598|interpro:IPR037213|interpro:IPR042654|rcsb pdb:5WRD|refseq:NP_001103723.2|refseq:NP_683727.3|refseq:XP_017168648.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:UQrU+0SySU+oBd+pE2OneGw0oog10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:P35922	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-645094	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:P39053	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-397785|ensembl:ENSMUSP00000122679|uniprotkb:A2AN50|uniprotkb:A2AN51|uniprotkb:A2AN54|uniprotkb:A2AN55|uniprotkb:Q3UNM1|uniprotkb:Q5DTN7|uniprotkb:Q61358|uniprotkb:Q61359|uniprotkb:Q61360|uniprotkb:Q6PDM5|uniprotkb:Q8JZZ4|uniprotkb:Q9CSY7|uniprotkb:Q9QXX1	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:dyn1_mouse(display_long)|uniprotkb:Dnm1(gene name)|psi-mi:Dnm1(display_short)|uniprotkb:Dnm(gene name synonym)|uniprotkb:Kiaa4093(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_034195.2|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:P39053|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|ensembl:ENSMUSG00000026825(gene)|ensembl:ENSMUST00000139624(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904645"(response to amyloid-beta)|refseq:NP_001288666.1|refseq:XP_006497721.2|refseq:XP_006497722.2|refseq:XP_006497723.2|refseq:XP_006497724.2|refseq:XP_006497718.2|refseq:XP_017170817.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:wtPz3gwyxU6tAgh5091LQpt099I10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:B9EJA2	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-16726062|ensembl:ENSMUSP00000088089|uniprotkb:G3X9L7|uniprotkb:Q69ZB2|uniprotkb:Q8BVG1|uniprotkb:Q8C044	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:cttb2_mouse(display_long)|uniprotkb:Cttnbp2(gene name)|psi-mi:Cttnbp2(display_short)|uniprotkb:Kiaa1758(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	ensembl:ENSMUST00000090601(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR002110(Ankyrin)|interpro:IPR019131|interpro:IPR020683|interpro:IPR036770|ensembl:ENSMUSG00000000416(gene)|refseq:NP_525024.1|refseq:XP_006505167.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:DCSkzHQr+dNIdM9ELmeBWbxVryg10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q02248	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:O54991	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-774794|uniprotkb:A2A4K6|ensembl:ENSMUSP00000099398	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:cntp1_mouse(display_long)|uniprotkb:Neurexin-4(gene name synonym)|uniprotkb:Neurexin IV(gene name synonym)|uniprotkb:Paranodin(gene name synonym)|uniprotkb:NCP1(gene name synonym)|uniprotkb:MHDNIV(gene name synonym)|uniprotkb:Cntnap1(gene name)|psi-mi:Cntnap1(display_short)|uniprotkb:Nrxn4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_058062.2|ensembl:ENSMUSG00000017167(gene)|ensembl:ENSMUST00000103109(transcript)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0005886"(plasma membrane)|go:"GO:0005918"(septate junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030424"(axon)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0033010"(paranodal junction)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR028872|interpro:IPR036056|mint:O54991	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:BTW+FjgSUq00WpWGDC6PpQcIowE10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:P15116	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-397974|uniprotkb:Q64260|uniprotkb:Q6GU11|intact:EBI-2255565|ensembl:ENSMUSP00000025166	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:cadh2_mouse(display_long)|uniprotkb:Cdh2(gene name)|psi-mi:Cdh2(display_short)|uniprotkb:Neural cadherin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_031690.3|ensembl:ENSMUSG00000024304(gene)|ensembl:ENSMUST00000025166(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030315"(T-tubule)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|interpro:IPR027397|interpro:IPR030051|interpro:IPR039808|mint:P15116|rcsb pdb:1NCG|rcsb pdb:1NCH|rcsb pdb:1NCI|rcsb pdb:1NCJ|rcsb pdb:1OP4|rcsb pdb:2QVI|rcsb pdb:3Q2W|rcsb pdb:4NUM|rcsb pdb:4NUP|rcsb pdb:4NUQ|reactome:R-MMU-381426|reactome:R-MMU-418990|reactome:R-MMU-525793|reactome:R-MMU-8957275|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090497"(mesenchymal cell migration)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|go:"GO:0043005"(neuron projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|dip:DIP-31564N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:Yon1udPwyvjKP2+GVGUcrsZtFng10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:P70408	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-16727790|ensembl:ENSMUSP00000042199|ensembl:ENSMUSP00000128782|uniprotkb:Q3UUB3|uniprotkb:Q80WS7	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:cad10_mouse(display_long)|uniprotkb:T2-cadherin(gene name synonym)|uniprotkb:Cdh10(gene name)|psi-mi:Cdh10(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	ensembl:ENSMUSG00000022321(gene)|ensembl:ENSMUST00000040562(transcript)|ensembl:ENSMUST00000166873(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0034332"(adherens junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR039808|rcsb pdb:6CG6|reactome:R-MMU-418990|refseq:NP_001303687.1|refseq:NP_033995.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:qcFZ51oDbh6HtvjWFmjiIAzscmM10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q6P9K8	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-771526|uniprotkb:Q6ZPU2|uniprotkb:Q8BWU2|uniprotkb:Q8BX99|uniprotkb:Q9CXH0|ensembl:ENSMUSP00000024958	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:cski1_mouse(display_long)|uniprotkb:CASK-interacting protein 1(gene name synonym)|uniprotkb:Caskin1(gene name)|psi-mi:Caskin1(display_short)|uniprotkb:Kiaa1306(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_082213.2|refseq:XP_006524378.1|ensembl:ENSMUSG00000033597(gene)|ensembl:ENSMUST00000024958(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001452(Src homology-3)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR027013|interpro:IPR032117|interpro:IPR032232|interpro:IPR035495|interpro:IPR035497|interpro:IPR035498|interpro:IPR036028|interpro:IPR036770|mint:Q6P9K8	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:zLkBAG7MLTXtMQ0HlY2ox2AumUE10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:P28652	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:P11798	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:Q8K3H0	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-400377|uniprotkb:Q3UJP7|uniprotkb:Q69ZJ9|uniprotkb:Q8BWZ8|uniprotkb:Q8VCJ8|uniprotkb:Q9CUW4|ensembl:ENSMUSP00000042875	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:dp13a_mouse(display_long)|uniprotkb:Appl1(gene name)|psi-mi:Appl1(display_short)|uniprotkb:Dip13a(gene name synonym)|uniprotkb:Kiaa1428(gene name synonym)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_660256.1|ensembl:ENSMUSG00000040760(gene)|ensembl:ENSMUST00000036570(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|interpro:IPR037929|mint:Q8K3H0|reactome:R-MMU-418889	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:1ZML/W0Qi+jMAeZQ7PXfiHA6YBE10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5SQX6	uniprotkb:P62484	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-15791842|ensembl:ENSMUSP00000058754|uniprotkb:Q6PHU3	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:abi2_mouse(display_long)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:Abi2(gene name)|psi-mi:Abi2(display_short)|uniprotkb:Abelson interactor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16727864|imex:IM-26285-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	ensembl:ENSMUSG00000026782(gene)|ensembl:ENSMUST00000052332(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007611"(learning or memory)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_001185499.1|refseq:NP_001185500.1|refseq:NP_937760.1|dip:DIP-48418N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/04/15	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:A5p3uqPuid61N78yiLHbnxA64mQ10090	rigid:/CE0YPDrq/7l9kL8sWZmXmaG+NI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q7TPH6	intact:EBI-645094	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9Z2D8	intact:EBI-645094	intact:EBI-1994548|uniprotkb:Q792D3|uniprotkb:Q8CFJ1|ensembl:ENSMUSP00000089948	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:mbd3_mouse(display_long)|uniprotkb:Mbd3(gene name)|psi-mi:Mbd3(display_short)|uniprotkb:Methyl-CpG-binding protein MBD3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001293072.1|refseq:NP_038623.1|dip:DIP-46518N|ensembl:ENSMUSG00000035478(gene)|ensembl:ENSMUST00000092295(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0016573"(histone acetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0048568"(embryonic organ development)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025884|interpro:IPR032343|interpro:IPR037965|mint:Q9Z2D8|reactome:R-MMU-3214815|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|go:"GO:0009888"(tissue development)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:1S5pGUEMFTEmqCNFTaaCgZFxG4E10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8CJG0	intact:EBI-645094	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6PDG5	intact:EBI-645094	intact:EBI-3870565|uniprotkb:Q6P6P3|ensembl:ENSMUSP00000100868	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:smrc2_mouse(display_long)|uniprotkb:Smarcc2(gene name)|psi-mi:Smarcc2(display_short)|uniprotkb:Baf170(gene name synonym)|uniprotkb:BRG1-associated factor 170(gene name synonym)|uniprotkb:SWI/SNF complex 170 kDa subunit(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001107568.1|refseq:NP_001107569.1|refseq:NP_937803.1|dip:DIP-48884N|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0042393"(histone binding)|ensembl:ENSMUSG00000025369(gene)|go:"GO:0043044"|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000953(Chromo domain)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR007526(SWIRM)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR032448|interpro:IPR032450|interpro:IPR032451|interpro:IPR036388|interpro:IPR036420|interpro:IPR038044|mint:Q6PDG5|reactome:R-MMU-3214858|reactome:R-MMU-8939243|ensembl:ENSMUST00000105235(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:v8cjo/1nUFl5vd96cKMcY8LA8M010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P62996	intact:EBI-645094	intact:EBI-8320461|uniprotkb:O15449|uniprotkb:Q64283|intact:MINT-4138402|uniprotkb:Q15815|ensembl:ENSMUSP00000124846	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:tra2b_mouse(display_long)|uniprotkb:Silg41(gene name synonym)|uniprotkb:Transformer-2 protein homolog B(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 10(gene name synonym)|uniprotkb:Silica-induced gene 41 protein(gene name synonym)|uniprotkb:Tra2b(gene name)|psi-mi:Tra2b(display_short)|uniprotkb:Sfrs10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_033212.1|refseq:NP_001317483.1|refseq:NP_001317484.1|ensembl:ENSMUSG00000022858(gene)|ensembl:ENSMUST00000161286(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:1990403"(embryonic brain development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P62996|reactome:R-MMU-72163|reactome:R-MMU-9013418|reactome:R-MMU-9013422	-	-	comment:mint|function:Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:6uZGeHEDlIVsb2uPeo+9NoR4tDw10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9EPQ8	intact:EBI-645094	intact:EBI-8339603|uniprotkb:Q60792|intact:MINT-4137206|uniprotkb:B9EHJ7|ensembl:ENSMUSP00000105136	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:tcf20_mouse(display_long)|uniprotkb:Tcf20(gene name)|psi-mi:Tcf20(display_short)|uniprotkb:Spbp(gene name synonym)|uniprotkb:Stromelysin-1 PDGF-responsive element-binding protein(gene name synonym)|uniprotkb:Nuclear factor SPBP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:XP_011243853.1|refseq:XP_011243855.1|refseq:NP_001107612.1|refseq:XP_006520795.1|refseq:XP_006520796.1|ensembl:ENSMUSG00000041852(gene)|ensembl:ENSMUST00000109510(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016604"(nuclear body)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR041972|mint:Q9EPQ8	-	-	comment:mint|function:Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:CjxG44drWFuxuDlwvqDTZLF3TCc10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q80YR5	intact:EBI-645094	intact:EBI-8339333|intact:MINT-4133756|uniprotkb:Q8K153|ensembl:ENSMUSP00000074953	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:safb2_mouse(display_long)|uniprotkb:Safb2(gene name)|psi-mi:Safb2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001025150.2|ensembl:ENSMUSG00000042625(gene)|ensembl:ENSMUST00000075510(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016604"(nuclear body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034782|interpro:IPR035979|interpro:IPR036361|mint:Q80YR5	-	-	comment:mint|function:"Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:3sn+PhoZmBj4kSqyAJCYLrk9ro810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6RHR9	intact:EBI-645094	intact:EBI-7440897|uniprotkb:O54894|uniprotkb:O54893|uniprotkb:O54895|intact:MINT-150460|ensembl:ENSMUSP00000086730	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:magi1_mouse(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_034497.1|refseq:NP_001025021.1|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0042995"(cell projection)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071944"(cell periphery)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030033|interpro:IPR036020|interpro:IPR036034|rcsb pdb:2I04|rcsb pdb:5ZYS	-	-	comment:mint|function:May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ACCN3 currents by modulating its expression at the cell surface	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P97379	intact:EBI-645094	intact:EBI-8319813|intact:MINT-1858459|uniprotkb:Q9R1B8|uniprotkb:Q3UL55|ensembl:ENSMUSP00000128244|ensembl:ENSMUSP00000128353|ensembl:ENSMUSP00000144456	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:g3bp2_mouse(display_long)|uniprotkb:G3bp2(gene name)|psi-mi:G3bp2(display_short)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_035946.2|refseq:NP_001074263.1|refseq:NP_001074266.1|refseq:XP_006534990.1|refseq:XP_006534991.1|ensembl:ENSMUSG00000029405(gene)|ensembl:ENSMUST00000164378(transcript)|ensembl:ENSMUST00000169094(transcript)|ensembl:ENSMUST00000202258(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:P97379	-	-	function:Probable scaffold protein that may be involved in mRNA transport|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:1MhDKzi09if4Beb23/9+ZTB0xKM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O35218	intact:EBI-645094	intact:EBI-8338633|intact:MINT-4091947|ensembl:ENSMUSP00000047797	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:cpsf2_mouse(display_long)|uniprotkb:Cpsf2(gene name)|psi-mi:Cpsf2(display_short)|uniprotkb:Cpsf100(gene name synonym)|uniprotkb:Mcpsf(gene name synonym)|uniprotkb:Cleavage and polyadenylation specificity factor 100 kDa subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_058552.1|refseq:XP_006516134.1|ensembl:ENSMUSG00000041781(gene)|ensembl:ENSMUST00000047357(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006398"(mRNA 3'-end processing by stem-loop binding and cleavage)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR025069|interpro:IPR027075|interpro:IPR035639|interpro:IPR036866|mint:O35218|reactome:R-MMU-159231|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|reactome:R-MMU-77595	-	-	comment:mint|function:"Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:XGmDv+2N0frKyW87Wt4gTx8rORo10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9JIY2	intact:EBI-645094	intact:EBI-7644904|ensembl:ENSMUSP00000099038|uniprotkb:Q8VCL9|uniprotkb:Q3TMC0|uniprotkb:Q8C7W5|intact:MINT-4129836	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:hakai_mouse(display_long)|uniprotkb:Cbll1(gene name)|psi-mi:Cbll1(display_short)|uniprotkb:Hakai(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:E-cadherin binding protein E7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000020659(gene)|ensembl:ENSMUST00000101499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q9JIY2|rcsb pdb:2MQ1|rcsb pdb:3VK6|reactome:R-MMU-983168|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|refseq:NP_598809.1|refseq:NP_001240776.1|refseq:NP_001240777.1	-	-	function:Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation|comment:mint|comment:homomint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:4iuLTA7wWaB7nwTRMs9MKWhn+5Y10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P53995	intact:EBI-645094	intact:EBI-8393433|intact:MINT-4087721|uniprotkb:A2ATQ4|uniprotkb:Q8BP33|uniprotkb:Q8C772|ensembl:ENSMUSP00000014499	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:apc1_mouse(display_long)|uniprotkb:Anapc1(gene name)|psi-mi:Anapc1(display_short)|uniprotkb:Mcpr(gene name synonym)|uniprotkb:Tsg24(gene name synonym)|uniprotkb:Cyclosome subunit 1(gene name synonym)|uniprotkb:Testis-specific gene 24 protein(gene name synonym)|uniprotkb:Mitotic checkpoint regulator(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_032595.2|ensembl:ENSMUSG00000014355(gene)|ensembl:ENSMUST00000014499(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR024990|interpro:IPR041221|mint:P53995|reactome:R-MMU-141430|reactome:R-MMU-174048|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-176407|reactome:R-MMU-176408|reactome:R-MMU-176409|reactome:R-MMU-176412|reactome:R-MMU-179409|reactome:R-MMU-2467813|reactome:R-MMU-2559582|reactome:R-MMU-69017|reactome:R-MMU-983168	-	-	function:"Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle"|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:PcGrcbi+iHpjseHz+LSfziOThg810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P83510	intact:EBI-645094	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	-	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8R151	intact:EBI-645094	intact:EBI-8366004|uniprotkb:A2A5R3|uniprotkb:Q3UEZ0|uniprotkb:Q3UD71|intact:MINT-4099298|uniprotkb:Q3U016|ensembl:ENSMUSP00000049404	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:znfx1_mouse(display_long)|uniprotkb:Znfx1(gene name)|psi-mi:Znfx1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001028368.2|refseq:XP_006500519.1|ensembl:ENSMUSG00000039501(gene)|ensembl:ENSMUST00000048988(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031380"(nuclear RNA-directed RNA polymerase complex)|interpro:IPR000967(Zinc finger, NF-X1-type)|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|mint:Q8R151	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:AC12ojPU7kh6+nJGZsCY089DFMk10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q7TQJ8	intact:EBI-645094	intact:EBI-7152090|ensembl:ENSMUSP00000047623|uniprotkb:Q8CG89|intact:MINT-8247474	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:wtip_mouse(display_long)|uniprotkb:Wtip(gene name)|psi-mi:Wtip(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000036459(gene)|ensembl:ENSMUST00000038537(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030030"(cell projection organization)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001781(Zinc finger, LIM-type)|reactome:R-MMU-1234176|refseq:NP_997095.1|dip:DIP-59507N	-	-	comment:mint|comment:homomint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:9p6K2jxwDwt6EXEbbyDVAvBzC/w10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8CGF6	intact:EBI-645094	intact:EBI-8316986|intact:MINT-4140349|uniprotkb:Q80TP4|uniprotkb:A2AGC7|ensembl:ENSMUSP00000057482	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:wdr47_mouse(display_long)|uniprotkb:Wdr47(gene name)|psi-mi:Wdr47(display_short)|uniprotkb:Kiaa0893(gene name synonym)|uniprotkb:Neuronal enriched MAP interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_852065.2|refseq:XP_017175308.1|dip:DIP-58945N|ensembl:ENSMUSG00000040389(gene)|ensembl:ENSMUST00000051145(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR036322|interpro:IPR040067|mint:Q8CGF6	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:t4myqVx9Xs1MBbib6vp11Wylu9Y10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P52479	intact:EBI-645094	intact:EBI-8327299|uniprotkb:Q6ZQG9|uniprotkb:Q91VY7|uniprotkb:Q3TZB8|intact:MINT-1870263|uniprotkb:Q3U5E0|uniprotkb:Q3T9L4|uniprotkb:Q3TNN5|ensembl:ENSMUSP00000104616	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ubp10_mouse(display_long)|uniprotkb:Usp10(gene name)|psi-mi:Usp10(display_short)|uniprotkb:Ode-1(gene name synonym)|uniprotkb:Uchrp(gene name synonym)|uniprotkb:Kiaa0190(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001297559.1|refseq:NP_033488.1|ensembl:ENSMUSG00000031826(gene)|ensembl:ENSMUST00000108988(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:P52479|reactome:R-MMU-5656169|reactome:R-MMU-5689880	-	-	comment:mint|function:Ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:tdoxBRcosuC3GGqMGB5pBKA9pKc10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q91VX2	intact:EBI-645094	intact:EBI-8393848|uniprotkb:Q812D6|intact:MINT-4121131|uniprotkb:Q99K40|ensembl:ENSMUSP00000030143	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ubap2_mouse(display_long)|uniprotkb:Ubap2(gene name)|psi-mi:Ubap2(display_short)|uniprotkb:Lig1(gene name synonym)|uniprotkb:Protein lingerer homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_081148.1|refseq:XP_006538287.1|ensembl:ENSMUSG00000028433(gene)|ensembl:ENSMUST00000030143(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q91VX2	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:1DmCkNUYKiOhbvmQCOs8L2+/vf010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q91W18	intact:EBI-645094	intact:EBI-8329718|uniprotkb:Q8C1A4|uniprotkb:Q8BZW6|intact:UNK-5479555|intact:MINT-4137349|uniprotkb:E9Q2Q4|intact:UNK-5512156|uniprotkb:Q6NZG7|ensembl:ENSMUSP00000129019	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:tdrd3_mouse(display_long)|uniprotkb:Tdrd3(gene name)|psi-mi:Tdrd3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001240684.1|refseq:NP_766193.3|ensembl:ENSMUSG00000022019(gene)|ensembl:ENSMUST00000168275(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006397"(mRNA processing)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035145"(exon-exon junction complex)|interpro:IPR002999(Tudor)|interpro:IPR009060(UBA-like)|interpro:IPR010304(Survival motor neuron)|interpro:IPR013894(Region of unknown function DUF1767)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR033472|interpro:IPR041915|interpro:IPR042470|mint:Q91W18|rcsb pdb:2D9T	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:OJkc6E7+tTHuVr5BSCn8MtiApZk10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8CHG7	intact:EBI-645094	intact:EBI-7027510|ensembl:ENSMUSP00000114119|intact:MINT-4133098|uniprotkb:E9QMD0	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:rpgf2_mouse(display_long)|uniprotkb:Rapgef2(gene name)|psi-mi:Rapgef2(display_short)|uniprotkb:Kiaa0313(gene name synonym)|uniprotkb:Pdzgef1(gene name synonym)|uniprotkb:Neural RAP guanine nucleotide exchange protein(gene name synonym)|uniprotkb:PDZ domain-containing guanine nucleotide exchange factor 1(gene name synonym)|uniprotkb:Cyclic nucleotide ras GEF(gene name synonym)|uniprotkb:RA-GEF-1(gene name synonym)|uniprotkb:Ras/Rap1-associating GEF-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:XP_006502317.1|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|go:"GO:0050699"(WW domain binding)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000159(Ras-association)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR018490|interpro:IPR023578|interpro:IPR029071|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030739|interpro:IPR036034|mint:Q8CHG7|reactome:R-MMU-5673001|ensembl:ENSMUSG00000062232(gene)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021591"(ventricular system development)|go:"GO:0021884"(forebrain neuron development)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038180"(nerve growth factor signaling pathway)|ensembl:ENSMUST00000118100(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001764"(neuron migration)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045202"(synapse)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048022"(negative regulation of melanin biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	comment:"fragmentation type: fragment"|comment:mint|comment:homomint|function:"Guanine nucleotide exchange factor (GEF) for Rap1, Rap1B and Rap2 GTPases"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:gH1WVMkcR44bJMCVvh7NctDb5KI10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P80560	intact:EBI-645094	intact:EBI-8538944|uniprotkb:P70328|uniprotkb:Q1RLJ1|intact:MINT-8310377|uniprotkb:O09134|ensembl:ENSMUSP00000064046	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ptpr2_mouse(display_long)|uniprotkb:Phogrin(gene name synonym)|uniprotkb:Protein tyrosine phosphatase-NP(gene name synonym)|uniprotkb:Ptprn2(gene name)|psi-mi:Ptprn2(display_short)|uniprotkb:PTP IA-2beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_035345.2|ensembl:ENSMUSG00000056553(gene)|ensembl:ENSMUST00000070733(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043235"(receptor complex)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|reactome:R-MMU-6798695	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:4Jw+Bh/t4Q1Z67SgT6vJzrO05SM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q3V1L4	intact:EBI-645094	intact:EBI-8347190|uniprotkb:Q8BZ43|intact:MINT-4113584|uniprotkb:Q6P223|uniprotkb:Q9D8G6|ensembl:ENSMUSP00000129126|ensembl:ENSMUSP00000158280	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:5ntc_mouse(display_long)|uniprotkb:Nt5c2(gene name)|psi-mi:Nt5c2(display_short)|uniprotkb:Cytosolic 5'-nucleotidase II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001157837.1|refseq:NP_084086.3|refseq:NP_001157835.1|refseq:XP_006527521.1|refseq:XP_006527522.1|ensembl:ENSMUSG00000025041(gene)|ensembl:ENSMUST00000168536(transcript)|ensembl:ENSMUST00000236501(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000255"(allantoin metabolic process)|go:"GO:0005829"(cytosol)|go:"GO:0006204"(IMP catabolic process)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0046040"(IMP metabolic process)|go:"GO:0046055"(dGMP catabolic process)|go:"GO:0046085"(adenosine metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050483"(IMP 5'-nucleotidase activity)|go:"GO:0050484"(GMP 5'-nucleotidase activity)|interpro:IPR008380(HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase)|interpro:IPR016695(Purine 5'-nucleotidase)|interpro:IPR023214|interpro:IPR036412|mint:Q3V1L4|reactome:R-MMU-2161541|reactome:R-MMU-74259	-	-	comment:mint|function:"May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:sRyb5lSKsOREwOmZJ6b+rjCYVpI10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8R4U7	intact:EBI-645094	intact:EBI-7991189|uniprotkb:Q8BQW1|uniprotkb:Q7TS71|uniprotkb:Q9CSL6|uniprotkb:Q99NG3|intact:MINT-4119192|uniprotkb:A3KG96|uniprotkb:Q3UV18|ensembl:ENSMUSP00000001116|ensembl:ENSMUSP00000060619|ensembl:ENSMUSP00000101475|ensembl:ENSMUSP00000130758	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:luzp1_mouse(display_long)|uniprotkb:Luzp1(gene name)|psi-mi:Luzp1(display_short)|uniprotkb:Luzp(gene name synonym)|uniprotkb:Leucine zipper motif-containing protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_077772.2|refseq:XP_006538984.1|ensembl:ENSMUSG00000001089(gene)|ensembl:ENSMUST00000001116(transcript)|ensembl:ENSMUST00000063021(transcript)|ensembl:ENSMUST00000105849(transcript)|ensembl:ENSMUST00000170102(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005634"(nucleus)|go:"GO:0021503"(neural fold bending)|go:"GO:0060840"(artery development)|interpro:IPR026734|mint:Q8R4U7	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:iDQj2aaSiq5/yW5J1vZ3YnF8ru410090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6Y7W8	intact:EBI-645094	intact:EBI-8652170|uniprotkb:Q8K0R0|uniprotkb:Q3UNS2|intact:MINT-266607|uniprotkb:Q8R0A3|uniprotkb:Q0VGQ7|uniprotkb:Q63ZU9|uniprotkb:Q80TV1|ensembl:ENSMUSP00000027475|ensembl:ENSMUSP00000133327	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ggyf2_mouse(display_long)|uniprotkb:Kiaa0642(gene name synonym)|uniprotkb:Perq2(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 15 protein(gene name synonym)|uniprotkb:Gigyf2(gene name)|psi-mi:Gigyf2(display_short)|uniprotkb:Tnrc15(gene name synonym)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001103682.1|refseq:NP_666224.3|refseq:XP_006529527.1|refseq:XP_006529528.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007631"(feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070064"(proline-rich region binding)|go:"GO:1990635"(proximal dendrite)|interpro:IPR003169(GYF)|interpro:IPR035445|ensembl:ENSMUSG00000048000(gene)|ensembl:ENSMUST00000027475(transcript)|ensembl:ENSMUST00000174501(transcript)	-	-	comment:mint|function:May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:XjYRWxaHyi+oSBy+5fX2jnJKU7I10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9WVR4	intact:EBI-645094	intact:EBI-8572772|uniprotkb:Q9WVR5|intact:UNK-5560063	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:fxr2_mouse(display_long)|uniprotkb:Fxr2(gene name)|psi-mi:Fxr2(display_short)|uniprotkb:Fxr2h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	interpro:IPR032172|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0045182"(translation regulator activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR022034|interpro:IPR008395(Agenet)|interpro:IPR004088(K Homology, type 1)|interpro:IPR040472|interpro:IPR040148|interpro:IPR036612|interpro:IPR041560	-	-	function:RNA-binding protein|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:q56uykuU0MnJ8r9/CdCuFG+ML0M10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q61584	intact:EBI-645094	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	-	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6A0A9	intact:EBI-645094	intact:EBI-8327719|intact:MINT-1858841|uniprotkb:Q91Z16|uniprotkb:B3DFJ0|uniprotkb:A0PJK6|ensembl:ENSMUSP00000053877	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:f120a_mouse(display_long)|uniprotkb:Kiaa0183(gene name synonym)|uniprotkb:Ossa(gene name synonym)|uniprotkb:Oxidative stress-associated Src activator(gene name synonym)|uniprotkb:Protein FAM120A(gene name synonym)|uniprotkb:FAM120A(gene name)|psi-mi:FAM120A(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001028440.2|ensembl:ENSMUSG00000038014(gene)|ensembl:ENSMUST00000060805(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR026784|interpro:IPR029060|mint:Q6A0A9	-	-	comment:"fragmentation type: fragment"|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:tZj0TOhfuvvF4GaEPHI7jWpKyl810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q61701	intact:EBI-645094	intact:EBI-8339146|uniprotkb:A2A9R6|uniprotkb:A2A9R8|uniprotkb:A2A9S0|uniprotkb:A2A9S1|uniprotkb:A2A9S2|uniprotkb:A2A9S3|uniprotkb:Q6PHZ3|uniprotkb:Q8BVA9|intact:MINT-4094262|uniprotkb:O55010|uniprotkb:A2A9R7|ensembl:ENSMUSP00000102207	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:elav4_mouse(display_long)|uniprotkb:Elavl4(gene name)|psi-mi:Elavl4(display_short)|uniprotkb:Hud(gene name synonym)|uniprotkb:Paraneoplastic encephalomyelitis antigen HuD(gene name synonym)|uniprotkb:Hu-antigen D(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001033787.1|refseq:NP_034618.2|refseq:NP_001334107.1|refseq:XP_006502862.1|ensembl:ENSMUSG00000028546(gene)|ensembl:ENSMUST00000106597(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008306"(associative learning)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031099"(regeneration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0097158"(pre-mRNA intronic pyrimidine-rich binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1905870"(positive regulation of 3'-UTR-mediated mRNA stabilization)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034918|interpro:IPR035979|mint:Q61701	-	-	function:May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:HXthuBphfQOW5EWQAG1smb8ljZY10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q60900	intact:EBI-645094	intact:EBI-8322932|uniprotkb:Q60901|intact:MINT-4094236|ensembl:ENSMUSP00000003501	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:elav3_mouse(display_long)|uniprotkb:Elavl3(gene name)|psi-mi:Elavl3(display_short)|uniprotkb:Huc(gene name synonym)|uniprotkb:Hu-antigen C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_034617.1|refseq:XP_006510085.1|ensembl:ENSMUSG00000003410(gene)|ensembl:ENSMUST00000003501(transcript)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034915|interpro:IPR035979|mint:Q60900|rcsb pdb:1D8Z|rcsb pdb:1D9A|rcsb pdb:1FNX	-	-	function:May be involved in neuronal differentiation and maintenance|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:qUvIDm1H0L+uyA+cVP6Kjefc2N810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q60899	intact:EBI-645094	intact:EBI-8329853|intact:MINT-4094224|ensembl:ENSMUSP00000008633	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:elav2_mouse(display_long)|uniprotkb:Elavl2(gene name)|psi-mi:Elavl2(display_short)|uniprotkb:Hub(gene name synonym)|uniprotkb:Hu-antigen B(gene name synonym)|uniprotkb:ELAV-like neuronal protein 1(gene name synonym)|uniprotkb:Nervous system-specific RNA-binding protein Mel-N1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_034616.1|refseq:XP_006502852.1|refseq:XP_006502853.1|refseq:XP_006502854.1|ensembl:ENSMUSG00000008489(gene)|ensembl:ENSMUST00000008633(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0045202"(synapse)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034914|interpro:IPR034999|interpro:IPR035979|mint:Q60899|reactome:R-MMU-72163	-	-	comment:mint|function:Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:dgDCiu1mN8mz6K95+ihBGQY8K8k10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6NZJ6	intact:EBI-645094	intact:EBI-8175606|uniprotkb:Q6NZN8|uniprotkb:Q8BW99|intact:MINT-1856450|ensembl:ENSMUSP00000047678|ensembl:ENSMUSP00000111120	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:if4g1_mouse(display_long)|uniprotkb:Eif4g1(gene name)|psi-mi:Eif4g1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001291361.1|refseq:NP_666053.2|refseq:XP_006522000.1|dip:DIP-42771N|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098794"(postsynapse)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1905537"(positive regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905612"(positive regulation of mRNA cap binding)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1905696"(regulation of polysome binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|reactome:R-MMU-975957|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584|mint:Q6NZJ6|reactome:R-MMU-1169408|reactome:R-MMU-156827|reactome:R-MMU-166208|reactome:R-MMU-429947|reactome:R-MMU-450408|reactome:R-MMU-72649|reactome:R-MMU-72662|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|ensembl:ENSMUSG00000045983(gene)|ensembl:ENSMUST00000044783(transcript)|ensembl:ENSMUST00000115460(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006412"(translation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034645"(cellular macromolecule biosynthetic process)	-	-	comment:mint|function:Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:91tJB28zzWTM77Jg0kZ18KIUhmo10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8C008	intact:EBI-645094	intact:EBI-8317102|uniprotkb:Q8C060|intact:MINT-4113786|uniprotkb:A2AN93|ensembl:ENSMUSP00000080643	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dzan1_mouse(display_long)|uniprotkb:Dzank1(gene name)|psi-mi:Dzank1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_766447.2|ensembl:ENSMUSG00000037259(gene)|ensembl:ENSMUST00000081982(transcript)|go:"GO:0046872"(metal ion binding)|interpro:IPR025874|interpro:IPR026876|interpro:IPR036770|mint:Q8C008	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:ozGQu95/TVKGDwRgLlTCq+bl3PM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O70305	intact:EBI-645094	intact:EBI-8006253|uniprotkb:P97421|intact:MINT-1865582	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:atx2_mouse(display_long)|uniprotkb:Atxn2(gene name)|psi-mi:Atxn2(display_short)|uniprotkb:Atx2(gene name synonym)|uniprotkb:Sca2(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 2 protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	interpro:IPR033093|refseq:NP_033151.2|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR025852|mint:O70305|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050905"(neuromuscular process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:SbI0yjYObe6jYhmgokZb1LLJlP810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q61315	intact:EBI-645094	intact:EBI-7848277|uniprotkb:Q62044|intact:UNK-5461725	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:apc_mouse(display_long)|uniprotkb:Apc(gene name)|psi-mi:Apc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0001822"(kidney development)|go:"GO:0001942"(hair follicle development)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009798"(axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042483"(negative regulation of odontogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043588"(skin development)|go:"GO:0044295"(axonal growth cone)|go:"GO:0031253"(cell projection membrane)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044337"(canonical Wnt signaling pathway involved in positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051171"(regulation of nitrogen compound metabolic process)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070852"(cell body fiber)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000211"(regulation of glutamate metabolic process)|rcsb pdb:1VJ6|reactome:R-MMU-111465|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3769402|reactome:R-MMU-4641262|reactome:R-MMU-5689896|interpro:IPR032038|mint:Q61315|interpro:IPR009224(SAMP)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009232(EB-1 binding)|interpro:IPR026818|interpro:IPR011989(Armadillo-like helical)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR026836|interpro:IPR036149|interpro:IPR041257	-	-	function:Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. APC activity is correlated with its phosphorylation state|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:5LB5NjRyV0VFe8xzCkg3/o+44g410090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9Z1D7	intact:EBI-645094	intact:EBI-16728802|ensembl:ENSMUSP00000058904|ensembl:ENSMUSP00000097308|ensembl:ENSMUSP00000153548|uniprotkb:Q8R0D8	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:zsc12_mouse(display_long)|uniprotkb:Zinc finger protein 96(gene name synonym)|uniprotkb:Zscan12(gene name)|psi-mi:Zscan12(display_short)|uniprotkb:Zfp96(gene name synonym)|uniprotkb:Znf96(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000036721(gene)|ensembl:ENSMUST00000053293(transcript)|ensembl:ENSMUST00000099720(transcript)|ensembl:ENSMUST00000225545(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR038269|refseq:NP_057893.2|refseq:XP_006516723.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:IczI02R2mJ9lLyL9IVu8nT926Ns10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6IQX8	intact:EBI-645094	intact:EBI-3044006|ensembl:ENSMUSP00000068184|ensembl:ENSMUSP00000126854|ensembl:ENSMUSP00000154709|uniprotkb:Q921W9|uniprotkb:Q924S6|uniprotkb:Q9CVF3|intact:EBI-3508329	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:zn219_mouse(display_long)|uniprotkb:Znf219(gene name)|psi-mi:Znf219(display_short)|uniprotkb:Zfp219(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000049295(gene)|ensembl:ENSMUST00000067549(transcript)|ensembl:ENSMUST00000166169(transcript)|ensembl:ENSMUST00000226522(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0060174"(limb bud formation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q6IQX8|refseq:XP_011243478.1|refseq:XP_011243479.1|refseq:XP_017171669.1|refseq:NP_081524.2|refseq:NP_001240623.1|refseq:NP_001240624.1|refseq:XP_006519561.1|refseq:XP_006519562.1|refseq:XP_006519564.1|refseq:XP_006519565.1|refseq:XP_006519566.1|refseq:XP_006519567.1|refseq:XP_006519568.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:Q6ebFbVDwgd46TS1dBOEk3kNYO410090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q91VL9	intact:EBI-645094	intact:EBI-16728761|ensembl:ENSMUSP00000041955|uniprotkb:Q8CDP7|uniprotkb:Q99LD2	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:zbtb1_mouse(display_long)|uniprotkb:Zbtb1(gene name)|psi-mi:Zbtb1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000033454(gene)|ensembl:ENSMUST00000042779(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002711"(positive regulation of T cell mediated immunity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048538"(thymus development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:2000176"(positive regulation of pro-T cell differentiation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|refseq:NP_848859.1|refseq:XP_006515958.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:YA6vdjmm++mG7Y/h2ZD5wgYIooc10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q5I043	intact:EBI-645094	intact:EBI-16728724|ensembl:ENSMUSP00000047467|uniprotkb:Q6NZP3|uniprotkb:Q6ZPP1|uniprotkb:Q8BWI1	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ubp28_mouse(display_long)|uniprotkb:Deubiquitinating enzyme 28(gene name synonym)|uniprotkb:Ubiquitin thioesterase 28(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 28(gene name synonym)|uniprotkb:Usp28(gene name)|psi-mi:Usp28(display_short)|uniprotkb:Kiaa1515(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000032267(gene)|ensembl:ENSMUST00000047349(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q5I043|reactome:R-MMU-5689880|refseq:NP_780691.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:BzdWmsJwWpIcQAPcUj9x+ZEYE0s10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:A2AN08	intact:EBI-645094	intact:EBI-4285947|uniprotkb:A2AN07|uniprotkb:A2AN09|uniprotkb:A2AN10|uniprotkb:A2AN11|uniprotkb:Q52KI4|uniprotkb:Q6PB49|uniprotkb:Q6PFC7|uniprotkb:Q80Y11|uniprotkb:Q8BGB9|uniprotkb:Q8C3E8|uniprotkb:Q8C4W5|uniprotkb:Q8C8X7|uniprotkb:Q8CGE0|uniprotkb:Q8CHF3|ensembl:ENSMUSP00000095433	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ubr4_mouse(display_long)|uniprotkb:Kiaa0462(gene name synonym)|uniprotkb:Zubr1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Ubr4(gene name)|psi-mi:Ubr4(display_short)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:p600(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001153791.1|dip:DIP-61499N|ensembl:ENSMUSG00000066036(gene)|ensembl:ENSMUST00000097822(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:A2AN08|reactome:R-MMU-6798695|reactome:R-MMU-983168|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:dTpQoZkH0+rwfrguOvzwrbPh0+Y10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P70399	intact:EBI-645094	intact:EBI-769130|uniprotkb:Q68FD0|uniprotkb:Q8CI97|uniprotkb:Q91YC9|intact:EBI-11051502|intact:EBI-11516626|uniprotkb:A2AU89|uniprotkb:A2AU91|ensembl:ENSMUSP00000106278	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:tp53b_mouse(display_long)|uniprotkb:Tp53bp1(gene name)|psi-mi:Tp53bp1(display_short)|uniprotkb:Trp53bp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001277759.1|refseq:NP_038763.3|dip:DIP-31595N|refseq:XP_011237883.1|ensembl:ENSMUSG00000043909(gene)|ensembl:ENSMUST00000110648(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:P70399|rcsb pdb:1SSF|reactome:R-MMU-3232118|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:z5tOHbR6ApNZRL9aptim/xRaVo010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q569Z6	intact:EBI-645094	intact:EBI-2536252|ensembl:ENSMUSP00000079722	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:tr150_mouse(display_long)|uniprotkb:Thrap3(gene name)|psi-mi:Thrap3(display_short)|uniprotkb:Trap150(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 150 kDa component(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000043962(gene)|ensembl:ENSMUST00000080919(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR026667|interpro:IPR029199|go:"GO:0008380"(RNA splicing)|refseq:XP_011238805.1|refseq:NP_666265.3|refseq:XP_006503104.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:Cb0vHuEX3Ew27z2gvfC/36tdeYE10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8BHJ5	intact:EBI-645094	intact:EBI-1216384|uniprotkb:Q3UWL6|uniprotkb:Q8CBG4|uniprotkb:Q8VEG3|uniprotkb:Q9EQD4|ensembl:ENSMUSP00000067164|ensembl:ENSMUSP00000141363|ensembl:ENSMUSP00000142184|ensembl:ENSMUSP00000144436	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:tbl1r_mouse(display_long)|uniprotkb:Tbl1xr1(gene name)|psi-mi:Tbl1xr1(display_short)|uniprotkb:Ira1(gene name synonym)|uniprotkb:Tblr1(gene name synonym)|uniprotkb:Transducin beta-like 1X-related protein 1(gene name synonym)|uniprotkb:Nuclear receptor corepressor/HDAC3 complex subunit TBLR1(gene name synonym)|uniprotkb:TBL1-related protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_109657.2|refseq:XP_011248020.1|refseq:XP_011248023.1|refseq:XP_011248021.1|refseq:XP_006535642.1|refseq:XP_006535643.1|refseq:XP_017175306.1|dip:DIP-38606N|ensembl:ENSMUSG00000027630(gene)|ensembl:ENSMUST00000063988(transcript)|ensembl:ENSMUST00000192328(transcript)|ensembl:ENSMUST00000193734(transcript)|ensembl:ENSMUST00000202747(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0002021"(response to dietary excess)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042393"(histone binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060613"(fat pad development)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q8BHJ5|rcsb pdb:5NAF|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-9029569|reactome:R-MMU-9707564	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:yq19+P14lXTgaMDi8JXFd5B2dic10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q920B9	intact:EBI-645094	intact:EBI-2549823|uniprotkb:Q3TZ48|uniprotkb:Q3UFH0|uniprotkb:Q921H4	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:sp16h_mouse(display_long)|uniprotkb:Supt16h(gene name)|psi-mi:Supt16h(display_short)|uniprotkb:Fact140(gene name synonym)|uniprotkb:Factp140(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex subunit SPT16(gene name synonym)|uniprotkb:FACT 140 kDa subunit(gene name synonym)|uniprotkb:FACTp140(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 140 kDa subunit(gene name synonym)|uniprotkb:Supt16(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034724"(DNA replication-independent chromatin organization)|go:"GO:0035101"(FACT complex)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR029149|interpro:IPR033825|interpro:IPR036005|interpro:IPR040258|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-6796648|interpro:IPR029148|reactome:R-MMU-6804756|reactome:R-MMU-75955|interpro:IPR013953(FACT complex subunit Spt16p/Cdc68p)|refseq:NP_291096.2|dip:DIP-55972N|mint:Q920B9	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:qcl0ckY0w3tIem/ezLyPtHVUnZA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8C804	intact:EBI-645094	intact:EBI-2364887|uniprotkb:Q8K3I7|ensembl:ENSMUSP00000058832	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:spice_mouse(display_long)|uniprotkb:Ccdc52(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 52(gene name synonym)|uniprotkb:Spice1(gene name)|psi-mi:Spice1(display_short)|uniprotkb:D16Ertd480e(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_653133.3|refseq:XP_017172412.1|ensembl:ENSMUSG00000043065(gene)|ensembl:ENSMUST00000050897(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR031387	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:ooOc9RIErFGvKSf3y0b6dcYddWw10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:E1U8D0	intact:EBI-645094	intact:EBI-16728709	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:soga1_mouse(display_long)|uniprotkb:SOGA family member 1(gene name synonym)|uniprotkb:Suppressor of glucose by autophagy(gene name synonym)|uniprotkb:Suppressor of glucose, autophagy-associated protein 1(gene name synonym)|uniprotkb:Soga1(gene name)|psi-mi:Soga1(display_short)|uniprotkb:Soga(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0005615"(extracellular space)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0045721"(negative regulation of gluconeogenesis)|interpro:IPR027882|interpro:IPR027881	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:Kk7DCpjGgjPDQ/NrzlscsMuBDGg10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P61406	intact:EBI-645094	intact:EBI-16728668|ensembl:ENSMUSP00000043555|uniprotkb:Q5NC64	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:est1a_mouse(display_long)|uniprotkb:EST1-like protein A(gene name synonym)|uniprotkb:Ever shorter telomeres 1A(gene name synonym)|uniprotkb:Smg-6 homolog(gene name synonym)|uniprotkb:Telomerase subunit EST1A(gene name synonym)|uniprotkb:Smg6(gene name)|psi-mi:Smg6(display_short)|uniprotkb:Est1a(gene name synonym)|uniprotkb:Kiaa0732(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR002716(PilT protein, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR018834|interpro:IPR019458|interpro:IPR029060|reactome:R-MMU-975957|ensembl:ENSMUSG00000038290(gene)|ensembl:ENSMUST00000045281(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042162"(telomeric DNA binding)|refseq:NP_001002764.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:eFSHXJCZXFz1idFVHCAyy6Itqos10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q3TKT4	intact:EBI-645094	intact:EBI-1210244|uniprotkb:Q6AXG8|uniprotkb:Q3TUD7|ensembl:ENSMUSP00000133922	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:smca4_mouse(display_long)|uniprotkb:Smarca4(gene name)|psi-mi:Smarca4(display_short)|uniprotkb:Baf190a(gene name synonym)|uniprotkb:Brg1(gene name synonym)|uniprotkb:Snf2b(gene name synonym)|uniprotkb:Snf2l4(gene name synonym)|uniprotkb:ATP-dependent helicase SMARCA4(gene name synonym)|uniprotkb:BRG1-associated factor 190A(gene name synonym)|uniprotkb:Protein brahma homolog 1(gene name synonym)|uniprotkb:SNF2-beta(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001167549.1|refseq:NP_001167550.1|refseq:NP_035547.2|refseq:XP_006510180.2|refseq:XP_006510182.2|refseq:XP_006510183.2|dip:DIP-40650N|dip:DIP-59249N|ensembl:ENSMUSG00000032187(gene)|ensembl:ENSMUST00000174008(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001188"(RNA polymerase I preinitiation complex assembly)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0001889"(liver development)|go:"GO:0002039"(p53 binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007399"(nervous system development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0007507"(heart development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010424"(DNA methylation on cytosine within a CG sequence)|go:"GO:0010467"(gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030900"(forebrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030957"(Tat protein binding)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035887"(aortic smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0043044"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048562"(embryonic organ morphogenesis)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902661"(positive regulation of glucose mediated signaling pathway)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030100|interpro:IPR036427|interpro:IPR038718|mint:Q3TKT4|reactome:R-MMU-1266695|reactome:R-MMU-201722|reactome:R-MMU-3214858|reactome:R-MMU-3247509|reactome:R-MMU-8939243|interpro:IPR037259	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:uLQrygmWWugY//OpA2aX4t2VgmM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q62141	intact:EBI-645094	intact:EBI-591450|uniprotkb:O54976|uniprotkb:Q6A013|uniprotkb:Q8VCB8|uniprotkb:Q8VDZ5|ensembl:ENSMUSP00000004494	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:sin3b_mouse(display_long)|uniprotkb:Transcriptional corepressor Sin3b(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3b(gene name synonym)|uniprotkb:Sin3b(gene name)|psi-mi:Sin3b(display_short)|uniprotkb:Kiaa0700(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001106719.1|refseq:NP_033214.2|dip:DIP-470N|ensembl:ENSMUSG00000031622(gene)|ensembl:ENSMUST00000004494(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0016580"(Sin3 complex)|go:"GO:0030849"(autosome)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048738"(cardiac muscle tissue development)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR039774|mint:Q62141|rcsb pdb:1E91|rcsb pdb:1PD7|rcsb pdb:2CR7|rcsb pdb:2CZY|rcsb pdb:2F05|rcsb pdb:5Y95|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9707564|go:"GO:0016575"(histone deacetylation)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:RILCV7LIlLhVsSBz43m63WcJ0B810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q80U72	intact:EBI-645094	intact:EBI-1766028|uniprotkb:Q6P5H7|uniprotkb:Q7TPH8|uniprotkb:Q80VB1|uniprotkb:Q8CI48|uniprotkb:Q8VII1|uniprotkb:Q922S3|ensembl:ENSMUSP00000068056	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:scrib_mouse(display_long)|uniprotkb:Scrib(gene name)|psi-mi:Scrib(display_short)|uniprotkb:Kiaa0147(gene name synonym)|uniprotkb:Lap4(gene name synonym)|uniprotkb:Scrib1(gene name synonym)|uniprotkb:Protein LAP4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_598850.1|refseq:XP_017171844.1|refseq:NP_001297471.1|refseq:NP_001297472.1|dip:DIP-40660N|ensembl:ENSMUSG00000022568(gene)|ensembl:ENSMUST00000063747(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001843"(neural tube closure)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0008104"(protein localization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016477"(cell migration)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036034|mint:Q80U72|reactome:R-MMU-9013148|reactome:R-MMU-9013406|reactome:R-MMU-9696264|reactome:R-MMU-9696270	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:WF4b5QAjIGIgq6tnexNZtDhI7gk10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P46061	intact:EBI-645094	intact:EBI-1033051|uniprotkb:Q60801|uniprotkb:Q6NZB5|ensembl:ENSMUSP00000057771|ensembl:ENSMUSP00000126849|ensembl:ENSMUSP00000130046	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ragp1_mouse(display_long)|uniprotkb:Rangap1(gene name)|psi-mi:Rangap1(display_short)|uniprotkb:Fug1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001139646.1|refseq:NP_035371.4|ensembl:ENSMUSG00000022391(gene)|ensembl:ENSMUST00000052374(transcript)|ensembl:ENSMUST00000170134(transcript)|ensembl:ENSMUST00000171115(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46061|rcsb pdb:1KPS|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108232|reactome:R-MMU-4615885|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9615933|reactome:R-MMU-9648025|dip:DIP-17024N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:XrJlIJ7cGqaUyNGBsK1ifk0YbmU10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9ERU9	intact:EBI-645094	intact:EBI-643756|uniprotkb:E9QM01|uniprotkb:Q61992|uniprotkb:Q8C9K9|ensembl:ENSMUSP00000003310	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:rbp2_mouse(display_long)|uniprotkb:Ran-binding protein 2(gene name synonym)|uniprotkb:Ranbp2(gene name)|psi-mi:Ranbp2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_035370.2|reactome:R-MMU-191859|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-4615885|reactome:R-MMU-5578749|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|ensembl:ENSMUSG00000003226(gene)|ensembl:ENSMUST00000003310(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006457"(protein folding)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR022011|interpro:IPR029000|interpro:IPR036443|mint:Q9ERU9|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:cjIAIF0uuxSMRXErJiJc+OBJpAw10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9JIF0	intact:EBI-645094	intact:EBI-519055|uniprotkb:Q99LS4|ensembl:ENSMUSP00000103474	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:anm1_mouse(display_long)|uniprotkb:Prmt1(gene name)|psi-mi:Prmt1(display_short)|uniprotkb:Mrmt1(gene name synonym)|uniprotkb:Hrmt1l2(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000109324(gene)|ensembl:ENSMUST00000107843(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016275"([cytochrome c]-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019919"(peptidyl-arginine methylation, to asymmetrical-dimethyl arginine)|go:"GO:0030519"(snoRNP binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0035247"(peptidyl-arginine omega-N-methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q9JIF0|reactome:R-MMU-3214858|reactome:R-MMU-8936459|reactome:R-MMU-9009391|reactome:R-MMU-9018519|refseq:NP_062804.1|refseq:NP_001239405.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:r9A3nCdPjfUjlHiIDRqKxH5DumI10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P62137	intact:EBI-645094	intact:EBI-357187|ensembl:ENSMUSP00000039109|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:Q3U7G7|uniprotkb:Q9Z1G2	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:pp1a_mouse(display_long)|uniprotkb:Ppp1ca(gene name)|psi-mi:Ppp1ca(display_short)|uniprotkb:Ppp1a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62137|rcsb pdb:5ZQV|rcsb pdb:5ZT0|reactome:R-MMU-180024|ensembl:ENSMUSG00000040385(gene)|ensembl:ENSMUST00000046094(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|refseq:NP_114074.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:kr38FkfqhN5ex5rxh4ZJbSdd8IM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9R0L6	intact:EBI-645094	intact:EBI-4284371|uniprotkb:O70287|uniprotkb:Q3URH6|uniprotkb:Q7TMS7|uniprotkb:Q8C9V2|uniprotkb:Q91Y27|uniprotkb:Q91Y28|uniprotkb:Q91Y51|uniprotkb:Q9CRK8|uniprotkb:Q923L0|uniprotkb:Q9CT57|uniprotkb:E9QLK2|ensembl:ENSMUSP00000039709	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:pcm1_mouse(display_long)|uniprotkb:Pcm1(gene name)|psi-mi:Pcm1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_076151.2|refseq:XP_006509361.1|ensembl:ENSMUSG00000031592(gene)|ensembl:ENSMUST00000045218(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q9R0L6|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-380320	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:OT+ZOQY5pqQojMcLCWMIY+6zdl410090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P60335	intact:EBI-645094	intact:EBI-309059|ensembl:ENSMUSP00000054863	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:pcbp1_mouse(display_long)|uniprotkb:Pcbp1(gene name)|psi-mi:Pcbp1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_035995.1|ensembl:ENSMUSG00000051695(gene)|ensembl:ENSMUST00000053015(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008494"(translation activator activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:P60335|reactome:R-MMU-72163|reactome:R-MMU-72203	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:x72fawo4plQ+ipfqIoREIDHc2bA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8BSQ9	intact:EBI-645094	intact:EBI-5744069|uniprotkb:E9QPW1|uniprotkb:Q05C64|uniprotkb:Q05CL6|uniprotkb:Q7TMP1|uniprotkb:Q7TNU2|uniprotkb:Q9CV51|ensembl:ENSMUSP00000107724	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:pb1_mouse(display_long)|uniprotkb:Pbrm1(gene name)|psi-mi:Pbrm1(display_short)|uniprotkb:Baf180(gene name synonym)|uniprotkb:Pb1(gene name synonym)|uniprotkb:BRG1-associated factor 180(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0043044"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001487(Bromodomain)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR018359|interpro:IPR036427|interpro:IPR036910|interpro:IPR037382|interpro:IPR037968|interpro:IPR043151|mint:Q8BSQ9|rcsb pdb:2YQD|reactome:R-MMU-3214858|ensembl:ENSMUSG00000042323(gene)|ensembl:ENSMUST00000112095(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0001825"(blastocyst formation)|go:"GO:0001890"(placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003349"(epicardium-derived cardiac endothelial cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016586"(RSC-type complex)|dip:DIP-48885N|reactome:R-MMU-8939243	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:7T640XCpm6UfVO9GB/HJKZZbd7E10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q99NH2	intact:EBI-645094	intact:EBI-6299697|uniprotkb:Q58T10|uniprotkb:Q58T11|uniprotkb:Q8CB21	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:pard3_mouse(display_long)|uniprotkb:Pard3(gene name)|psi-mi:Pard3(display_short)|uniprotkb:Par3(gene name synonym)|uniprotkb:Atypical PKC isotype-specific-interacting protein(gene name synonym)|uniprotkb:Ephrin-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001013598.1|refseq:NP_001013599.1|go:"GO:0008104"(protein localization)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043296"(apical junction complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|rcsb pdb:2KOH|rcsb pdb:2KOJ|reactome:R-MMU-2173791|reactome:R-MMU-420029|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003383"(apical constriction)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|dip:DIP-41727N|mint:Q99NH2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:T32+accBUmq14vv2OXj2mZe9fzQ10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8C015	intact:EBI-645094	intact:EBI-16728624|ensembl:ENSMUSP00000047285|ensembl:ENSMUSP00000076440|uniprotkb:Q3TQJ7|uniprotkb:Q6RWS7	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:pak5_mouse(display_long)|uniprotkb:p21-activated kinase 5(gene name synonym)|uniprotkb:p21-activated kinase 7(gene name synonym)|uniprotkb:Pak5(gene name)|psi-mi:Pak5(display_short)|uniprotkb:Pak7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000039913(gene)|ensembl:ENSMUST00000035264(transcript)|ensembl:ENSMUST00000077200(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028754|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013407|reactome:R-MMU-9013405|refseq:NP_766446.2|refseq:XP_006499572.1|refseq:XP_011237833.1|refseq:XP_017173706.1|refseq:XP_017173707.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:3r3/hAkAlWB3xoa0zEbeVJxDBy010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:B2RRE7	intact:EBI-645094	intact:EBI-16728605|ensembl:ENSMUSP00000133939|uniprotkb:B7ZNI5|uniprotkb:Q80TL3|uniprotkb:Q9CUN2	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:otud4_mouse(display_long)|uniprotkb:Otud4(gene name)|psi-mi:Otud4(display_short)|uniprotkb:Kiaa1046(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000036990(gene)|ensembl:ENSMUST00000173078(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|mint:B2RRE7|refseq:NP_001074633.1|refseq:NP_001242962.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:hvTooCUd0wIF+PvtoaDsmYWo4/s10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:E9Q7G0	intact:EBI-645094	intact:EBI-6907852|uniprotkb:Q80Y35|ensembl:ENSMUSP00000081912	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:numa1_mouse(display_long)|uniprotkb:Numa1(gene name)|psi-mi:Numa1(display_short)|uniprotkb:Nuclear mitotic apparatus protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000066306(gene)|ensembl:ENSMUST00000084852(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0055028"(cortical microtubule)|go:"GO:0055048"(anastral spindle assembly)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061673"(mitotic spindle astral microtubule)|refseq:XP_006507240.1|go:"GO:0070840"(dynein complex binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097427"(microtubule bundle)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097575"(lateral cell cortex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0099738"(cell cortex region)|go:"GO:1902365"(positive regulation of protein localization to spindle pole body)|go:"GO:1902846"(positive regulation of mitotic spindle elongation)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|go:"GO:1905720"(cytoplasmic microtubule bundle)|go:"GO:1905820"(positive regulation of chromosome separation)|go:"GO:1905832"(positive regulation of spindle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR026650|reactome:R-MMU-380320|reactome:R-MMU-68875|refseq:NP_598708.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:/yOsUga+jQmWlhNoGSJ78OsbPI810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q5F2E7	intact:EBI-645094	intact:EBI-11567759|uniprotkb:Q80TF1|uniprotkb:Q3V195|uniprotkb:Q3TCE2|ensembl:ENSMUSP00000098365	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:nufp2_mouse(display_long)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:Kiaa1321(gene name synonym)|uniprotkb:Nufip2(gene name)|psi-mi:Nufip2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001019376.1|refseq:XP_006534125.1|ensembl:ENSMUSG00000037857(gene)|ensembl:ENSMUST00000100802(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q5F2E7	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:rckz1rTUY3/RppScoXLaw1Z9ipU10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9D6T0	intact:EBI-645094	intact:EBI-16728579|ensembl:ENSMUSP00000003513|uniprotkb:Q9D8J9	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:nosip_mouse(display_long)|uniprotkb:E3 ubiquitin-protein ligase NOSIP(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NOSIP(gene name synonym)|uniprotkb:Nosip(gene name)|psi-mi:Nosip(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000003421(gene)|ensembl:ENSMUST00000003513(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016818(Nitric oxide synthase-interacting)|interpro:IPR031790|reactome:R-MMU-203754|refseq:NP_001157156.1|refseq:NP_079809.1|refseq:XP_017167721.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:VJCZ1XQRZNZuc6HrnLUNSUOFlQQ10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q80TM9	intact:EBI-645094	intact:EBI-6908752|ensembl:ENSMUSP00000022469|uniprotkb:Q2YDV7|uniprotkb:Q8C354|uniprotkb:Q8C4X9|uniprotkb:Q8CBH0|uniprotkb:Q91XW6|uniprotkb:Q99LG6|uniprotkb:Q9EPW8|uniprotkb:Q9WUM6	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:nisch_mouse(display_long)|uniprotkb:Nisch(gene name)|psi-mi:Nisch(display_short)|uniprotkb:Kiaa0975(gene name synonym)|uniprotkb:Imidazoline receptor 1(gene name synonym)|uniprotkb:Imidazoline receptor I-1-like protein(gene name synonym)|uniprotkb:Imidazoline-1 receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000021910(gene)|ensembl:ENSMUST00000022469(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048243"(norepinephrine secretion)|go:"GO:0055037"(recycling endosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001683(Phox-like)|interpro:IPR025875|interpro:IPR032675|interpro:IPR036871|interpro:IPR037904|mint:Q80TM9|reactome:R-MMU-9013149|reactome:R-MMU-9696264|reactome:R-MMU-9696270|refseq:NP_073147.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:4WK1HdDSTowpkrUNW9iMr+WB4t010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6KCD5	intact:EBI-645094	intact:EBI-2551962|ensembl:ENSMUSP00000059385|uniprotkb:Q8CES9|uniprotkb:Q8BKV4|uniprotkb:Q7TNS4|uniprotkb:Q6KC78|uniprotkb:Q9CUC6	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:nipbl_mouse(display_long)|uniprotkb:Nipbl(gene name)|psi-mi:Nipbl(display_short)|uniprotkb:Delangin homolog(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:Scc2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000022141(gene)|ensembl:ENSMUST00000052965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032039"(integrator complex)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR024986|interpro:IPR026003|interpro:IPR033031|mint:Q6KCD5|reactome:R-MMU-2470946|interpro:IPR016024(Armadillo-type fold)|refseq:NP_081983.2|refseq:NP_957684.1|refseq:XP_017172234.1|refseq:XP_006520057.1|refseq:XP_006520058.1|dip:DIP-56622N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:88SuibrHZTM4RLN0OfOJD1cMzCo10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P46935	intact:EBI-645094	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q61026	intact:EBI-645094	intact:EBI-688662|uniprotkb:E9QMH9|uniprotkb:O09001|uniprotkb:P97759|ensembl:ENSMUSP00000006037	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ncoa2_mouse(display_long)|uniprotkb:Transcriptional intermediary factor 2(gene name synonym)|uniprotkb:Glucocorticoid receptor-interacting protein 1(gene name synonym)|uniprotkb:Ncoa2(gene name)|psi-mi:Ncoa2(display_short)|uniprotkb:Grip1(gene name synonym)|uniprotkb:Tif2(gene name synonym)|uniprotkb:Src2(gene name synonym)|uniprotkb:Steroid receptor coactivator 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_032704.2|refseq:XP_006495528.1|dip:DIP-5979N|ensembl:ENSMUSG00000005886(gene)|ensembl:ENSMUST00000006037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028822|interpro:IPR032565|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q61026|rcsb pdb:1L2I|rcsb pdb:1OSV|rcsb pdb:1WM0|rcsb pdb:2Q6J|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QPY|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QZO|rcsb pdb:3MNE|rcsb pdb:3MNO|rcsb pdb:3MNP|reactome:R-MMU-159418|reactome:R-MMU-192105|reactome:R-MMU-193368|reactome:R-MMU-193807|reactome:R-MMU-211976|reactome:R-MMU-3214847|reactome:R-MMU-400206|reactome:R-MMU-5625886|reactome:R-MMU-9018519|reactome:R-MMU-9707564	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:NiMKYc0EqYC+ubVPFVRai8H/cNk10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P09405	intact:EBI-645094	intact:EBI-641864|uniprotkb:Q548M9|uniprotkb:Q61991|uniprotkb:Q8BQD8|uniprotkb:Q99K50|ensembl:ENSMUSP00000027438	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:nucl_mouse(display_long)|uniprotkb:Protein C23(gene name synonym)|uniprotkb:Ncl(gene name)|psi-mi:Ncl(display_short)|uniprotkb:Nuc(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_035010.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990631"(ErbB-4 class receptor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P09405|reactome:R-MMU-6791226|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000026234(gene)|ensembl:ENSMUST00000027438(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:NkPifysnX6CafgtN+Ko/p4aBqGE10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9EPN1	intact:EBI-645094	intact:EBI-527731|uniprotkb:Q8C931|uniprotkb:Q9EPM9|uniprotkb:Q9EPN0|uniprotkb:Q9WVM9|ensembl:ENSMUSP00000029374	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:nbea_mouse(display_long)|uniprotkb:Lysosomal-trafficking regulator 2(gene name synonym)|uniprotkb:Nbea(gene name)|psi-mi:Nbea(display_short)|uniprotkb:Lyst2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_085098.1|ensembl:ENSMUSG00000027799(gene)|ensembl:ENSMUST00000029374(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0008104"(protein localization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR010508(Protein of unknown function DUF1088)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023362|interpro:IPR031570|interpro:IPR036322|interpro:IPR036372|mint:Q9EPN1|refseq:XP_006501586.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:NWSzMiK/aQ6zHqkCxAoWJSqnrvA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q69ZK1	intact:EBI-645094	intact:EBI-16728565	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:q69zk1_mouse(display_long)|uniprotkb:N4bp2(gene name)|psi-mi:N4bp2(display_short)|uniprotkb:B3bp(gene name synonym)|uniprotkb:mKIAA1413(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0046404"(polydeoxyribonucleotide 5'-hydroxyl-kinase activity)|refseq:NP_001020088.1|interpro:IPR027417	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:Ie1hxZs2a1OzfMJeY2SwARSbSJE10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P60762	intact:EBI-645094	intact:EBI-2943018|ensembl:ENSMUSP00000082346|uniprotkb:Q8BNY9|uniprotkb:Q99MQ0	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:mo4l1_mouse(display_long)|uniprotkb:Morf4l1(gene name)|psi-mi:Morf4l1(display_short)|uniprotkb:Mrg15(gene name synonym)|uniprotkb:Tex189(gene name synonym)|uniprotkb:MORF-related gene 15 protein(gene name synonym)|uniprotkb:Testis-expressed gene 189 protein(gene name synonym)|uniprotkb:Transcription factor-like protein MRG15(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000062270(gene)|ensembl:ENSMUST00000085248(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003682"(chromatin binding)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006342"|go:"GO:0008283"(cell population proliferation)|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0047485"(protein N-terminus binding)|interpro:IPR008676(MRG)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR026541|interpro:IPR038011|interpro:IPR038217|mint:P60762|refseq:NP_001034236.1|refseq:NP_077751.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:8lFFlYOrwpJaf32UFUdVWMA8cJY10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P97820	intact:EBI-645094	intact:EBI-644181	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:m4k4_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase kinase 4(gene name synonym)|uniprotkb:HPK/GCK-like kinase HGK(gene name synonym)|uniprotkb:Nck-interacting kinase(gene name synonym)|uniprotkb:Map4k4(gene name)|psi-mi:Map4k4(display_short)|uniprotkb:Nik(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001239129.1|refseq:NP_001239130.1|refseq:NP_001239131.1|refseq:NP_032722.2|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-2559580|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032014"(positive regulation of ARF protein signal transduction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-40973N|mint:P97820	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:laMTX6DrOoTz4D8zxLP5ohzqKyw10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9QYH6	intact:EBI-645094	intact:EBI-1801274|uniprotkb:Q543L6|uniprotkb:Q99PB5|uniprotkb:Q9CYX1|ensembl:ENSMUSP00000026142	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:magd1_mouse(display_long)|uniprotkb:Maged1(gene name)|psi-mi:Maged1(display_short)|uniprotkb:Nrage(gene name synonym)|uniprotkb:MAGE-D1 antigen(gene name synonym)|uniprotkb:Neurotrophin receptor-interacting MAGE homolog(gene name synonym)|uniprotkb:Dlxin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_062765.1|interpro:IPR041898|interpro:IPR041899|mint:Q9QYH6|ensembl:ENSMUSG00000025151(gene)|ensembl:ENSMUST00000026142(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR030083|interpro:IPR037445	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:yQjDWQnoyOmw1R+BGkK3EO5blik10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9QXZ0	intact:EBI-645094	intact:EBI-643248|intact:EBI-2658096|uniprotkb:B1ARU3|uniprotkb:Q4PLL5|uniprotkb:P97394|uniprotkb:P97395|uniprotkb:P97396	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:macf1_mouse(display_long)|uniprotkb:Actin cross-linking family 7(gene name synonym)|uniprotkb:Macf1(gene name)|psi-mi:Macf1(display_short)|uniprotkb:Acf7(gene name synonym)|uniprotkb:Aclp7(gene name synonym)|uniprotkb:Macf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR002017(Spectrin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR001101(Plectin repeat)|interpro:IPR018159|interpro:IPR001452(Src homology-3)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0008104"(protein localization)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|mint:Q9QXZ0|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:niJxpkI45VTa5x73A1tuX/aLXgo10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q3UMG5	intact:EBI-645094	intact:EBI-16728543|ensembl:ENSMUSP00000108438|uniprotkb:A2AMN8|uniprotkb:Q7TNP9|uniprotkb:Q80TC9	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:lrch2_mouse(display_long)|uniprotkb:Lrch2(gene name)|psi-mi:Lrch2(display_short)|uniprotkb:Kiaa1495(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000031290(gene)|ensembl:ENSMUST00000112819(transcript)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036872|refseq:NP_001074642.1|refseq:XP_006528853.2|refseq:XP_006528854.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:+sAWZHf2327czTRMaLkHBa0SSek10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q5XJV6	intact:EBI-645094	intact:EBI-16726286|uniprotkb:A6BLZ0|uniprotkb:Q52KF1	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:lmtk3_mouse(display_long)|uniprotkb:Apoptosis-associated tyrosine kinase 3(gene name synonym)|uniprotkb:Lemur tyrosine kinase 3(gene name synonym)|uniprotkb:Lmtk3(gene name)|psi-mi:Lmtk3(display_short)|uniprotkb:Aatyk3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:Q5XJV6|refseq:NP_001005511.2|refseq:NP_001277919.1|refseq:XP_006541027.1|refseq:XP_017177816.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:FJgk1CZB0wgIbl5dhC81Wy7TRJE10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P70168	intact:EBI-645094	intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9QXL1	intact:EBI-645094	intact:EBI-911088|uniprotkb:E9PUY6|uniprotkb:P97424	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ki21b_mouse(display_long)|uniprotkb:Kinesin-like protein KIF6(gene name synonym)|uniprotkb:Kif21b(gene name)|psi-mi:Kif21b(display_short)|uniprotkb:Kif6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001034561.1|interpro:IPR019821|interpro:IPR001752(Kinesin, motor region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR027417|interpro:IPR027640|interpro:IPR036322|interpro:IPR036961|reactome:R-MMU-6811434|reactome:R-MMU-983189|reactome:R-MMU-2132295|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:1990939"	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:p5XA5tStORNyakd6slZvbCOfPfI10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:A2AIV2	intact:EBI-645094	intact:EBI-11664268|uniprotkb:A2AIV1|uniprotkb:Q3TDQ3|uniprotkb:Q3TRR9|uniprotkb:Q3U1Z2|uniprotkb:Q80TD6|uniprotkb:Q8C758|uniprotkb:Q8K151|uniprotkb:Q9CSI3|ensembl:ENSMUSP00000058078	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:vir_mouse(display_long)|uniprotkb:Virma(gene name)|psi-mi:Virma(display_short)|uniprotkb:Kiaa1429(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001333984.1|ensembl:ENSMUSG00000040720(gene)|ensembl:ENSMUST00000059914(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0080009"(mRNA methylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|interpro:IPR026736|interpro:IPR031801	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:Uw9MoM6vL4J/t5bEWPjIt7iHn4810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6ZQ88	intact:EBI-645094	intact:EBI-1216284|ensembl:ENSMUSP00000111977|uniprotkb:Q6PB53|uniprotkb:Q8VEA1|uniprotkb:A3KG94	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kdm1a_mouse(display_long)|uniprotkb:Kdm1a(gene name)|psi-mi:Kdm1a(display_short)|uniprotkb:Kiaa0601(gene name synonym)|uniprotkb:Lsd1(gene name synonym)|uniprotkb:Flavin-containing amine oxidase domain-containing protein 2(gene name synonym)|uniprotkb:BRAF35-HDAC complex protein BHC110(gene name synonym)|uniprotkb:Aof2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_598633.2|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032451"(demethylase activity)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032453"(histone H3-methyl-lysine-4 demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0032991"(protein-containing complex)|ensembl:ENSMUSG00000036940(gene)|ensembl:ENSMUST00000116273(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0008134"(transcription factor binding)|dip:DIP-38599N|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0033184"(positive regulation of histone ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034648"("obsolete histone demethylase activity (H3-dimethyl-K4 specific)")|go:"GO:0034649"("obsolete histone demethylase activity (H3-monomethyl-K4 specific)")|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0043426"(MRF binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046098"(guanine metabolic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0055001"(muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061752"(telomeric repeat-containing RNA binding)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1903827"|go:"GO:1990138"(neuron projection extension)|go:"GO:1990391"(DNA repair complex)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR002937(Amine oxidase)|interpro:IPR007526(SWIRM)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017366(Histone lysine-specific demethylase)|interpro:IPR036188|mint:Q6ZQ88|reactome:R-MMU-3214815|reactome:R-MMU-3214842|reactome:R-MMU-5625886|reactome:R-MMU-9018519|reactome:R-MMU-983231|interpro:IPR036388	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:4rlXgUzLs3mhV2FLX207Io9etU010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q99JP6	intact:EBI-645094	intact:EBI-6272061|ensembl:ENSMUSP00000117033|uniprotkb:D3Z6N9|uniprotkb:Q9Z215	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:home3_mouse(display_long)|uniprotkb:Homer3(gene name)|psi-mi:Homer3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000003573(gene)|ensembl:ENSMUST00000140212(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q99JP6|reactome:R-MMU-6794361|refseq:NP_001139625.1|refseq:NP_036114.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:7IOPI8VTi6aKK/I0tl4AiUUIXIU10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q4U2R1	intact:EBI-645094	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P70288	intact:EBI-645094	intact:EBI-302251|uniprotkb:B2RRP3	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:hdac2_mouse(display_long)|uniprotkb:Hdac2(gene name)|psi-mi:Hdac2(display_short)|uniprotkb:Yy1bp(gene name synonym)|uniprotkb:YY1 transcription factor-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-4551638|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-9022692|reactome:R-MMU-983231|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|refseq:NP_032255.2|dip:DIP-32854N|mint:P70288	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:bGLIDKTlyhBz40NViC8calRacZ010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9QZQ8	intact:EBI-645094	intact:EBI-3508334|uniprotkb:Q91VZ2|uniprotkb:Q9QZQ7|ensembl:ENSMUSP00000016081	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:h2ay_mouse(display_long)|uniprotkb:Macroh2a1(gene name)|psi-mi:Macroh2a1(display_short)|uniprotkb:H2A.y(gene name synonym)|uniprotkb:H2A/y(gene name synonym)|uniprotkb:H2afy(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001152985.1|refseq:NP_001152986.1|refseq:NP_001152987.1|refseq:NP_036145.1|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0001740"(Barr body)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902750"(negative regulation of cell cycle G2/M phase transition)|go:"GO:1902882"(regulation of response to oxidative stress)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:1902883"(negative regulation of response to oxidative stress)|go:"GO:0005730"(nucleolus)|go:"GO:1902884"(positive regulation of response to oxidative stress)|go:"GO:1903226"(positive regulation of endodermal cell differentiation)|go:"GO:1904815"(negative regulation of protein localization to chromosome, telomeric region)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002119(Histone H2A)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007125(Histone core)|go:"GO:0005813"(centrosome)|interpro:IPR009072(Histone-fold)|interpro:IPR021171|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|interpro:IPR032454|go:"GO:0007549"(dosage compensation)|interpro:IPR035796|interpro:IPR043472|mint:Q9QZQ8|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0019216"(regulation of lipid metabolic process)|ensembl:ENSMUSG00000015937(gene)|ensembl:ENSMUST00000016081(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000182"(rDNA binding)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:70q7YQGYxyE7ZBq8e7oOsIUSY0810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9WV60	intact:EBI-645094	intact:EBI-400793|ensembl:ENSMUSP00000023507	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:gsk3b_mouse(display_long)|uniprotkb:Gsk3b(gene name)|psi-mi:Gsk3b(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_062801.1|dip:DIP-32446N|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006983"(ER overload response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014043"(negative regulation of neuron maturation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034452"(dynactin binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:Q9WV60|rcsb pdb:4NU1|rcsb pdb:5AIR|rcsb pdb:6AE3|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3371453|reactome:R-MMU-399956|reactome:R-MMU-4641262|reactome:R-MMU-5250924|reactome:R-MMU-5610785|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046849"(bone remodeling)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0106027"(neuron projection organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904780"(negative regulation of protein localization to centrosome)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|ensembl:ENSMUSG00000022812(gene)|ensembl:ENSMUST00000023507(transcript)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:FKe0WkOBBYU0vIJLmcFNMJ+KVHA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q61545	intact:EBI-645094	intact:EBI-1606991|uniprotkb:Q9D2P0|ensembl:ENSMUSP00000078867	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ews_mouse(display_long)|uniprotkb:Ewsr1(gene name)|psi-mi:Ewsr1(display_short)|uniprotkb:Ews(gene name synonym)|uniprotkb:Ewsh(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_031994.2|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033109|interpro:IPR034869|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:Q61545|ensembl:ENSMUSG00000009079(gene)|ensembl:ENSMUST00000079949(transcript)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:bvajg+ZT71/K+6hwdHFdOewgvrw10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P84089	intact:EBI-645094	intact:EBI-2551866|ensembl:ENSMUSP00000021559|ensembl:ENSMUSP00000147411|uniprotkb:Q14259|uniprotkb:P70659	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:erh_mouse(display_long)|uniprotkb:Erh(gene name)|psi-mi:Erh(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000021131(gene)|ensembl:ENSMUSG00000063412(gene)|ensembl:ENSMUST00000021559(transcript)|ensembl:ENSMUST00000080152(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005634"(nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0034709"(methylosome)|interpro:IPR000781(Enhancer of rudimentary)|interpro:IPR035912|mint:P84089|rcsb pdb:1WWQ|rcsb pdb:1WZ7|refseq:NP_031977.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:foMOmvZ9wQyH0rrzBB2YlQhrT0g10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8BMB0	intact:EBI-645094	intact:EBI-5692419|uniprotkb:Q5FWK5|uniprotkb:Q80XU1|uniprotkb:Q8VDW9|ensembl:ENSMUSP00000145858	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:emsy_mouse(display_long)|uniprotkb:Emsy(gene name)|psi-mi:Emsy(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_758484.2|refseq:XP_006507693.1|ensembl:ENSMUSG00000035401(gene)|ensembl:ENSMUST00000205276(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0042802"(identical protein binding)|interpro:IPR005491(ENT)|interpro:IPR033482|interpro:IPR036142	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:6tpXN9UZYJ8X/cIfNkkJ3KTZjrc10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9Z148	intact:EBI-645094	intact:EBI-444966|uniprotkb:Q6PE08|uniprotkb:Q8K4R6|uniprotkb:Q8K4R7|uniprotkb:Q9Z149|uniprotkb:A2CG75|ensembl:ENSMUSP00000013931	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ehmt2_mouse(display_long)|uniprotkb:Histone H3-K9 methyltransferase 3(gene name synonym)|uniprotkb:Euchromatic histone-lysine N-methyltransferase 2(gene name synonym)|uniprotkb:HLA-B-associated transcript 8(gene name synonym)|uniprotkb:Protein G9a(gene name synonym)|uniprotkb:Ehmt2(gene name)|psi-mi:Ehmt2(display_short)|uniprotkb:G9a(gene name synonym)|uniprotkb:Ng36(gene name synonym)|uniprotkb:Bat8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_665829.1|refseq:NP_671493.1|refseq:NP_001273502.1|refseq:NP_001273504.1|ensembl:ENSMUSG00000013787(gene)|ensembl:ENSMUST00000013931(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007281"(germ cell development)|go:"GO:0007286"(spermatid development)|go:"GO:0007616"(long-term memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009566"(fertilization)|go:"GO:0010424"(DNA methylation on cytosine within a CG sequence)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035265"(organ growth)|go:"GO:0035690"|go:"GO:0036166"(phenotypic switching)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048665"(neuron fate specification)|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0060992"(response to fungicide)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR002110(Ankyrin)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR020683|interpro:IPR036770|interpro:IPR038034|interpro:IPR043550|mint:Q9Z148|reactome:R-MMU-2559582|reactome:R-MMU-3214841|reactome:R-MMU-6804760|reactome:R-MMU-73762|reactome:R-MMU-8953750|dip:DIP-31916N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:SN94zTs0cmZHuzgtVLjSTDtfOAM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q3UJB9	intact:EBI-645094	intact:EBI-2553526|uniprotkb:Q3U6U8|uniprotkb:Q8R223|uniprotkb:Q7TS78	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:edc4_mouse(display_long)|uniprotkb:Edc4(gene name)|psi-mi:Edc4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|reactome:R-MMU-430039|refseq:NP_001288029.1|interpro:IPR032401|refseq:NP_853625.1|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q3UJB9	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:FVX5K/2axUrzI66j1QPmJsqpxec10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q60838	intact:EBI-645094	intact:EBI-641940|uniprotkb:Q7TN14|ensembl:ENSMUSP00000099635|ensembl:ENSMUSP00000140073|ensembl:ENSMUSP00000019362	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dvl2_mouse(display_long)|uniprotkb:Dvl2(gene name)|psi-mi:Dvl2(display_short)|uniprotkb:DSH homolog 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_031914.3|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q60838|rcsb pdb:3ML6|rcsb pdb:6VCC|reactome:R-MMU-201688|reactome:R-MMU-2028269|reactome:R-MMU-4086400|reactome:R-MMU-4608870|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5099900|reactome:R-MMU-5663220|reactome:R-MMU-8856825|reactome:R-MMU-8856828|ensembl:ENSMUST00000019362(transcript)|ensembl:ENSMUST00000102575(transcript)|ensembl:ENSMUST00000190940(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060029"(convergent extension involved in organogenesis)|ensembl:ENSMUSG00000020888(gene)|dip:DIP-29399N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:bFjXy0cGGbY8YE60qW3+0NLpqNs10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8R1A4	intact:EBI-645094	intact:EBI-776274|uniprotkb:Q45V78|uniprotkb:Q5PRE6|uniprotkb:Q6PJ17|uniprotkb:Q9CSB6|uniprotkb:Q9CXM7	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dock7_mouse(display_long)|uniprotkb:Gm430(gene name synonym)|uniprotkb:Dock7(gene name)|psi-mi:Dock7(display_short)|uniprotkb:Kiaa1771(gene name synonym)|uniprotkb:Mnlt(gene name synonym)|uniprotkb:Protein moonlight(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	interpro:IPR027357|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR043162|interpro:IPR043161|interpro:IPR026791|interpro:IPR027007|interpro:IPR035892|interpro:IPR037808|mint:Q8R1A4|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043473"(pigmentation)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|reactome:R-MMU-8875555|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-983231	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:T4W30iJF8XaTuK57c9vlJFr9gpg10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P13864	intact:EBI-645094	intact:EBI-301927|uniprotkb:Q80ZU3|uniprotkb:Q9CSC6|uniprotkb:P97413|uniprotkb:Q9QXX6|ensembl:ENSMUSP00000004202	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dnmt1_mouse(display_long)|uniprotkb:Dnmt1(gene name)|psi-mi:Dnmt1(display_short)|uniprotkb:Dnmt(gene name synonym)|uniprotkb:Met1(gene name synonym)|uniprotkb:Uim(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase MmuI(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001186360.2|refseq:NP_001186361.1|refseq:NP_001186362.1|refseq:NP_034196.5|interpro:IPR031303|interpro:IPR043151|mint:P13864|rcsb pdb:3AV4|rcsb pdb:3AV5|rcsb pdb:3AV6|rcsb pdb:3PT6|rcsb pdb:3PT9|rcsb pdb:4DA4|rcsb pdb:5GUT|rcsb pdb:5GUV|rcsb pdb:5WY1|rcsb pdb:6W8V|rcsb pdb:6W8W|reactome:R-MMU-212300|reactome:R-MMU-4655427|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|ensembl:ENSMUST00000004202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010424"(DNA methylation on cytosine within a CG sequence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0044026"(DNA hypermethylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046500"(S-adenosylmethionine metabolic process)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:0016458"(obsolete gene silencing)|ensembl:ENSMUSG00000004099(gene)|refseq:NP_001300940.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:JgHTnDhDn4nuU6ww3jXfDPq01xY10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q80Y83	intact:EBI-645094	intact:EBI-16728485|ensembl:ENSMUSP00000034566|uniprotkb:Q3TPF4|uniprotkb:Q3UQ90|uniprotkb:Q5DPZ2|uniprotkb:Q5DPZ3|uniprotkb:Q5DPZ4|uniprotkb:Q5DPZ6|uniprotkb:Q6ZPJ2|uniprotkb:Q8C467|uniprotkb:Q8R1C1	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dixc1_mouse(display_long)|uniprotkb:Coiled-coil protein DIX1(gene name synonym)|uniprotkb:DIX domain-containing protein 1(gene name synonym)|uniprotkb:Dixdc1(gene name)|psi-mi:Dixdc1(display_short)|uniprotkb:Ccd1(gene name synonym)|uniprotkb:Kiaa1735(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000032064(gene)|ensembl:ENSMUST00000034566(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021869"(forebrain ventricular zone progenitor cell division)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|interpro:IPR001158(DIX)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR029071|interpro:IPR029800|interpro:IPR036872|interpro:IPR038207|rcsb pdb:5Y3B|refseq:NP_001297998.1|refseq:NP_835219.1|refseq:XP_006510517.1|refseq:XP_006510518.1|refseq:XP_006510519.1|refseq:XP_006510520.1|refseq:XP_017168928.1|refseq:XP_017168929.1|refseq:XP_017168930.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:tb4V0EZhcAZyt9mBElS+AG+NS/I10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q62167	intact:EBI-645094	intact:EBI-773173|uniprotkb:O09060|uniprotkb:O09143|ensembl:ENSMUSP00000000804	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ddx3x_mouse(display_long)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD3(gene name synonym)|uniprotkb:Embryonic RNA helicase(gene name synonym)|uniprotkb:D1Pas1-related sequence 2(gene name synonym)|uniprotkb:Ddx3x(gene name)|psi-mi:Ddx3x(display_short)|uniprotkb:D1Pas1-rs2(gene name synonym)|uniprotkb:Ddx3(gene name synonym)|uniprotkb:Dead3(gene name synonym)|uniprotkb:Erh(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_034158.1|ensembl:ENSMUSG00000000787(gene)|ensembl:ENSMUST00000000804(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q62167|reactome:R-MMU-6798695	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:K7PtRsPpXHni4TU8uzOsr6QaVxA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O54833	intact:EBI-645094	intact:EBI-1216452|ensembl:ENSMUSP00000055919|ensembl:ENSMUSP00000148404	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:csk22_mouse(display_long)|uniprotkb:Csnk2a2(gene name)|psi-mi:Csnk2a2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_034104.1|ensembl:ENSMUSG00000046707(gene)|ensembl:ENSMUST00000056919(transcript)|ensembl:ENSMUST00000212214(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0031519"(PcG protein complex)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O54833|reactome:R-MMU-1483191|reactome:R-MMU-201688|reactome:R-MMU-2514853|reactome:R-MMU-445144|reactome:R-MMU-6804756|reactome:R-MMU-6814122|reactome:R-MMU-8934903|reactome:R-MMU-8939243|reactome:R-MMU-8948751	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:6aE12BakwtzXfYRZ4EwCGSG5wBE10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q60737	intact:EBI-645094	intact:EBI-771698|uniprotkb:Q8R0X4|ensembl:ENSMUSP00000096829	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:csk21_mouse(display_long)|uniprotkb:Csnk2a1(gene name)|psi-mi:Csnk2a1(display_short)|uniprotkb:Ckiia(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_031814.2|refseq:XP_011237574.1|refseq:XP_006498720.1|dip:DIP-32409N|ensembl:ENSMUSG00000074698(gene)|ensembl:ENSMUST00000099224(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q60737|reactome:R-MMU-1483191|reactome:R-MMU-201688|reactome:R-MMU-2514853|reactome:R-MMU-445144|reactome:R-MMU-6804756|reactome:R-MMU-6814122|reactome:R-MMU-8934903|reactome:R-MMU-8939243|reactome:R-MMU-8948751	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:7UK+lLG3t/3xJi7CaiGSCIcxfPg10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q80TV8	intact:EBI-645094	intact:EBI-908322|uniprotkb:Q505G6|uniprotkb:Q6DI75|uniprotkb:Q6PG14|uniprotkb:Q8BNS4|uniprotkb:Q99JH5|uniprotkb:Q99JI2|uniprotkb:Q9CVU1	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:clap1_mouse(display_long)|uniprotkb:Clasp1(gene name)|psi-mi:Clasp1(display_short)|uniprotkb:Cytoplasmic linker-associated protein 1(gene name synonym)|uniprotkb:Kiaa0622(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001280229.1|refseq:NP_001280230.1|refseq:NP_083985.2|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024395|interpro:IPR021133|interpro:IPR028399|interpro:IPR034085|mint:Q80TV8|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0006903"(vesicle targeting)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0030981"(cortical microtubule cytoskeleton)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031592"(centrosomal corona)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0043515"(kinetochore binding)|go:"GO:0045180"(basal cortex)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-2500257	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:HwJCOu/w9CSWzqLB7WEjrC4a3bg10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:A2AJK6	intact:EBI-645094	intact:EBI-6122905|uniprotkb:Q3TA86|uniprotkb:Q3TAG7|uniprotkb:Q3TBU4|uniprotkb:Q8C986|uniprotkb:Q8K244|ensembl:ENSMUSP00000043903|ensembl:ENSMUSP00000059079	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:chd7_mouse(display_long)|uniprotkb:Chd7(gene name)|psi-mi:Chd7(display_short)|uniprotkb:ATP-dependent helicase CHD7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:XP_006538067.1|refseq:NP_001264078.1|ensembl:ENSMUSG00000041235(gene)|ensembl:ENSMUST00000039267(transcript)|ensembl:ENSMUST00000051558(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003226"(right ventricular compact myocardium morphogenesis)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006364"(rRNA processing)|go:"GO:0007417"(central nervous system development)|go:"GO:0007512"(adult heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0021545"(cranial nerve development)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030540"(female genitalia development)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035904"(aorta development)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043584"(nose development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048771"(tissue remodeling)|go:"GO:0048806"(genitalia development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060123"(regulation of growth hormone secretion)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060384"(innervation)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060429"(epithelium development)|go:"GO:0062009"(secondary palate development)|go:"GO:0070615"|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023780|interpro:IPR027417|interpro:IPR037259|interpro:IPR038718|mint:A2AJK6	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:xGLCgish7JPQt9t6qs7dcfThPGg10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6PDQ2	intact:EBI-645094	intact:EBI-3043852|ensembl:ENSMUSP00000060054	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:chd4_mouse(display_long)|uniprotkb:Chd4(gene name)|psi-mi:Chd4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000063870(gene)|ensembl:ENSMUST00000056889(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0016581"(NuRD complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0070615"|go:"GO:0072553"(terminal button organization)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR009462(Protein of unknown function DUF1086)|interpro:IPR009463(Protein of unknown function DUF1087)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR012957(CHD, C-terminal 2)|interpro:IPR012958(CHD, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR019786|interpro:IPR019787|interpro:IPR023780|interpro:IPR027417|interpro:IPR038718|mint:Q6PDQ2|reactome:R-MMU-3214815|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-9031628|reactome:R-MMU-6804758|refseq:NP_666091.1|refseq:NP_001333539.1|dip:DIP-59651N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:1ExHO4XVxVn9siWz99wuNhrnZMg10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8K389	intact:EBI-645094	intact:EBI-11068840|uniprotkb:Q6PCN1|uniprotkb:A2AVA1|uniprotkb:Q6ZPL0|ensembl:ENSMUSP00000119891	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ck5p2_mouse(display_long)|uniprotkb:Cdk5rap2(gene name)|psi-mi:Cdk5rap2(display_short)|uniprotkb:CDK5 activator-binding protein C48(gene name synonym)|uniprotkb:Kiaa1633(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_666102.2|ensembl:ENSMUSG00000039298(gene)|ensembl:ENSMUST00000144099(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR012943(Spindle associated)|interpro:IPR042791|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:DyXUSB0U+q7WgrdIW3HI3vjkpEo10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6A068	intact:EBI-645094	intact:EBI-2552123|ensembl:ENSMUSP00000024727|uniprotkb:Q8K1J9	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:cdc5l_mouse(display_long)|uniprotkb:Cdc5l(gene name)|psi-mi:Cdc5l(display_short)|uniprotkb:Kiaa0432(gene name synonym)|uniprotkb:Cdc5-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000023932(gene)|ensembl:ENSMUST00000024727(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|refseq:NP_690023.1|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904568"(cellular response to wortmannin)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017930|interpro:IPR021786|mint:Q6A068|reactome:R-MMU-72163|go:"GO:0005737"(cytoplasm)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:ehcu1kQlVD4/J1K3a77EcsjqRbI10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8VDP4	intact:EBI-645094	intact:EBI-2931660|ensembl:ENSMUSP00000036924|uniprotkb:Q6PIB1|uniprotkb:Q8BWR5|uniprotkb:Q8C0F0|uniprotkb:Q8R3G6	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ccar2_mouse(display_long)|uniprotkb:Ccar2(gene name)|psi-mi:Ccar2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000033712(gene)|ensembl:ENSMUST00000035612(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|interpro:IPR028811|mint:Q8VDP4|reactome:R-MMU-3371453|refseq:NP_666167.3|refseq:XP_006518959.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:4KqmxaC2o3+yWOF9dwQ9kQ7AMqs10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P23198	intact:EBI-645094	intact:EBI-78162|uniprotkb:Q921C4	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:cbx3_mouse(display_long)|uniprotkb:Cbx3(gene name)|psi-mi:Cbx3(display_short)|uniprotkb:Heterochromatin protein 1 homolog gamma(gene name synonym)|uniprotkb:Modifier 2 protein(gene name synonym)|uniprotkb:M32(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006325"(chromatin organization)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010369"(chromocenter)|go:"GO:0019899"(enzyme binding)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|interpro:IPR038033|reactome:R-MMU-73772|reactome:R-MMU-8953750|dip:DIP-28136N|mint:P23198	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:mD/Ut3JqLl3k0Ut98GxlstErEGs10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8K3W3	intact:EBI-645094	intact:EBI-12507190|ensembl:ENSMUSP00000017384|ensembl:ENSMUSP00000130926|uniprotkb:A3KFP7|uniprotkb:Q3UT99|uniprotkb:Q8K219|uniprotkb:Q99NF0	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:casc3_mouse(display_long)|uniprotkb:Casc3(gene name)|psi-mi:Casc3(display_short)|uniprotkb:Mln51(gene name synonym)|uniprotkb:Cancer susceptibility candidate gene 3 protein homolog(gene name synonym)|uniprotkb:Metastatic lymph node gene 51 protein homolog(gene name synonym)|uniprotkb:Protein barentsz(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000078676(gene)|ensembl:ENSMUST00000017384(transcript)|ensembl:ENSMUST00000169695(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR018545|interpro:IPR028544|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|reactome:R-MMU-975957|refseq:NP_619601.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:wkn5q2NoAFzhK7FdJ7mJFpjKZYU10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q99PV8	intact:EBI-645094	intact:EBI-11293861|uniprotkb:Q8C2I1|uniprotkb:Q99PV6|uniprotkb:Q99PV7|uniprotkb:Q9JLF8|ensembl:ENSMUSP00000068258	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:bc11b_mouse(display_long)|uniprotkb:Bcl11b(gene name)|psi-mi:Bcl11b(display_short)|uniprotkb:Ctip2(gene name synonym)|uniprotkb:Rit1(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 11B(gene name synonym)|uniprotkb:COUP-TF-interacting protein 2(gene name synonym)|uniprotkb:Radiation-induced tumor suppressor gene 1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001073352.1|refseq:NP_001273272.1|refseq:NP_067374.2|ensembl:ENSMUSG00000048251(gene)|ensembl:ENSMUST00000066060(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035701"(hematopoietic stem cell migration)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043368"(positive T cell selection)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043588"(skin development)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0071678"(olfactory bulb axon guidance)|go:"GO:0097535"(lymphoid lineage cell migration into thymus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:fcgBt1xNJI9kSOgCa+J7pNo5FNA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9QYE3	intact:EBI-645094	intact:EBI-16728430|ensembl:ENSMUSP00000000881|uniprotkb:Q80T89|uniprotkb:Q8BLC7|uniprotkb:Q8BLR4|uniprotkb:Q8BWX3|uniprotkb:Q921V4|uniprotkb:Q9D0V2|uniprotkb:Q9JIT4|uniprotkb:Q9JLK8|uniprotkb:Q9JLK9	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:bc11a_mouse(display_long)|uniprotkb:B-cell CLL/lymphoma 11A(gene name synonym)|uniprotkb:COUP-TF-interacting protein 1(gene name synonym)|uniprotkb:Ecotropic viral integration site 9 protein(gene name synonym)|uniprotkb:Bcl11a(gene name)|psi-mi:Bcl11a(display_short)|uniprotkb:Ctip1(gene name synonym)|uniprotkb:Evi9(gene name synonym)|uniprotkb:Kiaa1809(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000000861(gene)|ensembl:ENSMUST00000000881(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001067"(transcription regulatory region nucleic acid binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1904800"(negative regulation of neuron remodeling)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000173"(negative regulation of branching morphogenesis of a nerve)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|refseq:NP_001152761.1|refseq:NP_001152762.1|refseq:NP_001229863.1|refseq:NP_057916.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:SW548pSOkbqq8nXnVObx3a12FIg10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9Z1K7	intact:EBI-645094	intact:EBI-11785083	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:apcl_mouse(display_long)|uniprotkb:Apc2(gene name)|psi-mi:Apc2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	interpro:IPR026837|interpro:IPR009234(APC basic)|interpro:IPR026831|interpro:IPR026818|interpro:IPR032038|interpro:IPR009223(APC cysteine-rich)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|interpro:IPR009224(SAMP)|interpro:IPR041257|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001708"(cell fate specification)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098794"(postsynapse)|interpro:IPR036149	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:2rKvomUSC03KK5LuZdCCWvB+LCU10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q70FJ1	intact:EBI-645094	intact:EBI-645887|uniprotkb:Q3TH74|uniprotkb:Q80TR6	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:akap9_mouse(display_long)|uniprotkb:Akap9(gene name)|psi-mi:Akap9(display_short)|uniprotkb:Kiaa0803(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_919444.2|interpro:IPR019528|interpro:IPR028745|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007165"(signal transduction)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034705"(potassium channel complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044307"(dendritic branch)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097729"(9+2 motile cilium)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0120219"(subapical part of cell)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903358"(regulation of Golgi organization)|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5576890|reactome:R-MMU-5576893|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:Q70FJ1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:9yyCeoX35wNULJg413iGM9TIQxA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9DBR0	intact:EBI-645094	intact:EBI-4285802|uniprotkb:Q9R0L8|ensembl:ENSMUSP00000002699	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:akap8_mouse(display_long)|uniprotkb:Akap8(gene name)|psi-mi:Akap8(display_short)|uniprotkb:Akap95(gene name synonym)|uniprotkb:A-kinase anchor protein 95 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000024045(gene)|ensembl:ENSMUST00000002699(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001939"(female pronucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033127"(regulation of histone phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044839"(cell cycle G2/M phase transition)|go:"GO:0045087"(innate immune response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|interpro:IPR007071("A-kinase anchoring protein 95 (AKAP95)")|interpro:IPR034736|mint:Q9DBR0|refseq:NP_062748.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:CboiIO6b/r8YM0jLmJbCdzg5S3U10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P61164	intact:EBI-645094	intact:EBI-774242|uniprotkb:P42024|uniprotkb:Q3TJF9|ensembl:ENSMUSP00000039844	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:actz_mouse(display_long)|uniprotkb:Centrosome-associated actin homolog(gene name synonym)|uniprotkb:Actin-RPV(gene name synonym)|uniprotkb:ARP1(gene name synonym)|uniprotkb:Actr1a(gene name)|psi-mi:Actr1a(display_short)|uniprotkb:Ctrn1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_058556.1|ensembl:ENSMUSG00000025228(gene)|ensembl:ENSMUST00000040270(transcript)|go:"GO:0002177"(manchette)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0043209"(myelin sheath)|go:"GO:0099738"(cell cortex region)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P61164|reactome:R-MMU-2132295|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-8854518	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:aJHKOSj1qmZ7Pk8aZAyWWd8DEdw10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:F6SEU4	intact:EBI-645094	intact:EBI-5797569|ensembl:ENSMUSP00000141686	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q4ACU6	intact:EBI-645094	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q5DU25	intact:EBI-645094	intact:EBI-773452|uniprotkb:E9QK46	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:iqec2_mouse(display_long)|uniprotkb:Iqsec2(gene name)|psi-mi:Iqsec2(display_short)|uniprotkb:Kiaa0522(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000904(SEC7-like)|interpro:IPR023394|interpro:IPR033742|refseq:XP_006528908.1|interpro:IPR035999|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900454"(positive regulation of long-term synaptic depression)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:D2kDV/pgwPkXPHcK5+7S9+HS6Wk10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q68FF6	intact:EBI-645094	intact:EBI-645933|ensembl:ENSMUSP00000037210	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6PFD5	intact:EBI-645094	intact:EBI-2308733|uniprotkb:Q6PDX0|uniprotkb:Q6XBF2|ensembl:ENSMUSP00000039724|ensembl:ENSMUSP00000101700	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dlgp3_mouse(display_long)|uniprotkb:Dlgap3(gene name)|psi-mi:Dlgap3(display_short)|uniprotkb:Dap3(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 3(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:XP_011238839.1|refseq:NP_941020.1|refseq:NP_001289010.1|ensembl:ENSMUSG00000042388(gene)|ensembl:ENSMUST00000046659(transcript)|ensembl:ENSMUST00000106094(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023052"(signaling)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030526|mint:Q6PFD5|rcsb pdb:5IZU|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:mkXYwYR5Snou4RA8d71UDC7G59I10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q62108	intact:EBI-645094	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q91XM9	intact:EBI-645094	intact:EBI-400138|uniprotkb:Q8BXK7|uniprotkb:Q8BYG5|ensembl:ENSMUSP00000102814|uniprotkb:F8VQM7	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dlg2_mouse(display_long)|uniprotkb:Dlg2(gene name)|psi-mi:Dlg2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000052572(gene)|ensembl:ENSMUST00000107196(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035759|interpro:IPR036028|interpro:IPR036034|mint:Q91XM9|rcsb pdb:2WL7|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6794361|refseq:NP_001229976.1|refseq:NP_035937.2|dip:DIP-31569N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:37/IFbjDNxh87dnN2gglIgDGyIU10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q811D0	intact:EBI-645094	intact:EBI-514290|uniprotkb:Q62402|uniprotkb:Q6PGB5|uniprotkb:Q8CGN7|ensembl:ENSMUSP00000097581|ensembl:ENSMUSP00000110859	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dlg1_mouse(display_long)|uniprotkb:Synapse-associated protein 97(gene name synonym)|uniprotkb:Embryo-dlg/synapse-associated protein 97(gene name synonym)|uniprotkb:Dlg1(gene name)|psi-mi:Dlg1(display_short)|uniprotkb:Dlgh1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_031888.2|refseq:NP_001239362.1|refseq:NP_001239364.1|refseq:XP_006521831.1|refseq:NP_001239363.1|dip:DIP-31591N|ensembl:ENSMUSG00000022770(gene)|ensembl:ENSMUST00000100001(transcript)|ensembl:ENSMUST00000115205(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034629"|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043219"(lateral loop)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060022"(hard palate development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1902473"(regulation of protein localization to synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903286"(regulation of potassium ion import)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903760"(regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:1903764"(regulation of potassium ion export across plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR015143(L27-1)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q811D0|rcsb pdb:4OAJ|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-8849932	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:b8LjYbiuR2K6/jxhwU1hxBJKX6410090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:A2AGT5	intact:EBI-645094	intact:EBI-910980|uniprotkb:A0PJ77|uniprotkb:A2AGT6|uniprotkb:B2RRC4|uniprotkb:Q0VGR0|uniprotkb:Q3TML9|uniprotkb:Q3UDY6|uniprotkb:Q9CUN0|uniprotkb:Q4VAE7	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ckap5_mouse(display_long)|uniprotkb:Ckap5(gene name)|psi-mi:Ckap5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_083713.2|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024395|interpro:IPR021133|interpro:IPR034085|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008017"(microtubule binding)|go:"GO:0008542"(visual learning)|go:"GO:0010609"(mRNA localization resulting in posttranscriptional regulation of gene expression)|go:"GO:0022618"(ribonucleoprotein complex assembly)|go:"GO:0030425"(dendrite)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043204"(perikaryon)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046959"(habituation)|go:"GO:0050658"(RNA transport)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061863"(microtubule plus end polymerase)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098794"(postsynapse)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:fUm3RHxuyZP1aUHZq+R7EvuGlWY10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O88737	intact:EBI-645094	intact:EBI-400493|uniprotkb:Q6ZQB5|uniprotkb:E9QMZ3|ensembl:ENSMUSP00000035208	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:bsn_mouse(display_long)|uniprotkb:Bsn(gene name)|psi-mi:Bsn(display_short)|uniprotkb:Kiaa0434(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_031593.2|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045202"(synapse)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0050808"(synapse organization)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099526"(presynapse to nucleus signaling pathway)|go:"GO:1904071"(presynaptic active zone assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:1990257"(piccolo-bassoon transport vesicle)|interpro:IPR008899(Zinc finger, piccolo-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR030627|mint:O88737|ensembl:ENSMUSG00000032589(gene)|ensembl:ENSMUST00000035208(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|refseq:XP_006511697.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:W4w0sRW518SHtgLQ/mY/unJDgwc10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P61205	intact:EBI-645094	intact:EBI-444797|uniprotkb:P16587|ensembl:ENSMUSP00000050689	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:arf3_mouse(display_long)|uniprotkb:Arf3(gene name)|psi-mi:Arf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_031504.1|refseq:XP_011243747.1|ensembl:ENSMUSG00000051853(gene)|ensembl:ENSMUST00000053183(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P61205|reactome:R-MMU-1660514|reactome:R-MMU-6807878|reactome:R-MMU-6811434	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:np09WjdbXRu9vgMbiXn9EA3ExqA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8BGS3	intact:EBI-645094	intact:EBI-16728399|ensembl:ENSMUSP00000019660|uniprotkb:Q7TS88|uniprotkb:Q8BJ55|uniprotkb:Q9CRN6	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:zksc1_mouse(display_long)|uniprotkb:Zkscan1(gene name)|psi-mi:Zkscan1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000029729(gene)|ensembl:ENSMUST00000019660(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|interpro:IPR038269|interpro:IPR041697|reactome:R-MMU-212436|refseq:NP_084145.1|refseq:NP_598667.2|refseq:XP_006504691.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:C2kv/nmjaM465Ju6DQmSmlZ2TlM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O88532	intact:EBI-645094	intact:EBI-645485|uniprotkb:Q3TY30|uniprotkb:Q8BS85|uniprotkb:Q8CGG5|uniprotkb:Q91VZ0|uniprotkb:Q9CT34|ensembl:ENSMUSP00000118911	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:zfr_mouse(display_long)|uniprotkb:Zfr(gene name)|psi-mi:Zfr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_035897.2|ensembl:ENSMUSG00000022201(gene)|ensembl:ENSMUST00000122941(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:O88532	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:ncNwFUEUk0r2XotuXm/9Tt4iB5w10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8BJH1	intact:EBI-645094	intact:EBI-6666361|ensembl:ENSMUSP00000054734|uniprotkb:Q3TCP6	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:zc21a_mouse(display_long)|uniprotkb:Zc2hc1a(gene name)|psi-mi:Zc2hc1a(display_short)|uniprotkb:Fam164a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000043542(gene)|ensembl:ENSMUST00000051064(transcript)|go:"GO:0046872"(metal ion binding)|interpro:IPR026319|mint:Q8BJH1|refseq:NP_775273.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:Btr5djUOQ8lcE2sGzTFwvOkAv8E10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6VNB8	intact:EBI-645094	intact:EBI-2935491|ensembl:ENSMUSP00000052607|uniprotkb:Q8C8H7	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:wdfy3_mouse(display_long)|uniprotkb:Wdfy3(gene name)|psi-mi:Wdfy3(display_short)|uniprotkb:Beach domain, WD repeat and FYVE domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUST00000053177(transcript)|go:"GO:0003831"(beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|ensembl:ENSMUSG00000043940(gene)|go:"GO:0046872"(metal ion binding)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036322|interpro:IPR036372|refseq:NP_766470.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:usZZNZVZAzV8ubWsp5y077sivvI10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P70398	intact:EBI-645094	intact:EBI-2214043|uniprotkb:E9QLY0|uniprotkb:Q62497	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:usp9x_mouse(display_long)|uniprotkb:Ubiquitin thioesterase FAF-X(gene name synonym)|uniprotkb:Usp9x(gene name)|psi-mi:Usp9x(display_short)|uniprotkb:Fafl(gene name synonym)|uniprotkb:Fam(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-X(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-X(gene name synonym)|uniprotkb:Fat facets protein-related, X-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, X chromosome(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase FAM(gene name synonym)|uniprotkb:Fat facets homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	interpro:IPR016024(Armadillo-type fold)|interpro:IPR028889|refseq:NP_033507.2|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:P70398|interpro:IPR038765|interpro:IPR021905|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021698"(cerebellar cortex structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0030426"(growth cone)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045177"(apical part of cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|reactome:R-MMU-2173795|reactome:R-MMU-5689880|reactome:R-MMU-8866652|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-9033241	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:QXx5gkd+PxoNgIj2b2dLjpCuNr410090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:A2RSJ4	intact:EBI-645094	intact:EBI-11566394|uniprotkb:Q8CHD4|uniprotkb:B2RQV0|uniprotkb:E9QMH4|ensembl:ENSMUSP00000020112	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:uh1bl_mouse(display_long)|uniprotkb:Kiaa0701(gene name synonym)|uniprotkb:Uhrf1bp1l(gene name)|psi-mi:Uhrf1bp1l(display_short)|uniprotkb:Ship164(gene name synonym)|uniprotkb:Syntaxin-6 Habc-interacting protein of 164 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_083442.2|ensembl:ENSMUSG00000019951(gene)|ensembl:ENSMUST00000020112(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0062069"(GARP complex binding)|interpro:IPR026728|interpro:IPR026854|reactome:R-MMU-9696270	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:d1f8XL4s1WH75RYJaSDLG1iF6j010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q80X50	intact:EBI-645094	intact:EBI-11664310|uniprotkb:Q8BIT6|uniprotkb:Q8BIW4|uniprotkb:Q8BJ01|uniprotkb:Q8CIG7|uniprotkb:Q8K102|uniprotkb:Q9CRT6|ensembl:ENSMUSP00000143459	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ubp2l_mouse(display_long)|uniprotkb:Ubap2l(gene name)|psi-mi:Ubap2l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001159455.1|refseq:NP_001159456.1|refseq:NP_001159457.1|refseq:NP_001159458.1|refseq:NP_082751.1|refseq:XP_006502235.1|ensembl:ENSMUSG00000042520(gene)|ensembl:ENSMUST00000196843(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q80X50|rcsb pdb:1WJ7	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:ucHEy1MXF7PTEdwLChr6zAOqtcM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9R1R2	intact:EBI-645094	intact:EBI-775991|uniprotkb:Q3UMU5|ensembl:ENSMUSP00000053384|ensembl:ENSMUSP00000102401|ensembl:ENSMUSP00000114822	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:trim3_mouse(display_long)|uniprotkb:RING finger protein 22(gene name synonym)|uniprotkb:RING finger protein HAC1(gene name synonym)|uniprotkb:Trim3(gene name)|psi-mi:Trim3(display_short)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Rnf22(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001272799.1|refseq:NP_001272800.1|refseq:NP_001272802.1|refseq:NP_061368.1|ensembl:ENSMUSG00000036989(gene)|ensembl:ENSMUST00000057525(transcript)|ensembl:ENSMUST00000106789(transcript)|ensembl:ENSMUST00000147044(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001258(NHL repeat)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR017907|interpro:IPR027370|mint:Q9R1R2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:fOQH1BPgmOXrJXOb8VYYFpNX0UQ10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q62318	intact:EBI-645094	intact:EBI-346909|uniprotkb:P70391|uniprotkb:Q8C283|uniprotkb:Q99PN4|ensembl:ENSMUSP00000005705	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:tif1b_mouse(display_long)|uniprotkb:Trim28(gene name)|psi-mi:Trim28(display_short)|uniprotkb:Krip1(gene name synonym)|uniprotkb:Tif1b(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:KRAB-A-interacting protein(gene name synonym)|uniprotkb:KRIP-1(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:Kap1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_035718.2|dip:DIP-31477N|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q62318|rcsb pdb:6O5K|reactome:R-MMU-212436|ensembl:ENSMUSG00000005566(gene)|ensembl:ENSMUST00000005705(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:DvGJxQNohVWs++QEAyrqe4ngcz810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9Z321	intact:EBI-645094	intact:EBI-16728364|ensembl:ENSMUSP00000023465|ensembl:ENSMUSP00000156132	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:top3b_mouse(display_long)|uniprotkb:DNA topoisomerase III beta-1(gene name synonym)|uniprotkb:Top3b(gene name)|psi-mi:Top3b(display_short)|uniprotkb:Top3b1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000022779(gene)|ensembl:ENSMUST00000023465(transcript)|ensembl:ENSMUST00000232581(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007059"(chromosome segregation)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|mint:Q9Z321|refseq:NP_001313505.1|refseq:NP_035754.1|refseq:XP_006522054.1|refseq:XP_006522055.1|refseq:XP_006522057.1|refseq:XP_006522058.1|refseq:XP_017172426.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:9m6mpZ7aIV3fx3bU6opc3sFN3SA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:E9Q0S6	intact:EBI-645094	intact:EBI-8792524|ensembl:ENSMUSP00000127715	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:e9q0s6_mouse(display_long)|uniprotkb:Tns1(gene name)|psi-mi:Tns1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000055322(gene)|ensembl:ENSMUST00000169786(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0010761"(fibroblast migration)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|refseq:NP_082160.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:NwxyQLlVTkwCu60tx4fMp2LZmwc10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8BKI2	intact:EBI-645094	intact:EBI-9030490|uniprotkb:Q80TK4|ensembl:ENSMUSP00000064336	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:tnr6b_mouse(display_long)|uniprotkb:Tnrc6b(gene name)|psi-mi:Tnrc6b(display_short)|uniprotkb:Kiaa1093(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_659061.2|dip:DIP-48568N|ensembl:ENSMUSG00000047888(gene)|ensembl:ENSMUST00000067689(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR019486|interpro:IPR032226|interpro:IPR033500|interpro:IPR034925|interpro:IPR035979|mint:Q8BKI2|reactome:R-MMU-426496	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:zFkNbprE9NdhNf4a/bcBU+nHcac10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8BYI9	intact:EBI-645094	intact:EBI-774167|uniprotkb:A2RT70|uniprotkb:O88717|ensembl:ENSMUSP00000107298|ensembl:ENSMUSP00000141553	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:tenr_mouse(display_long)|uniprotkb:Restrictin(gene name synonym)|uniprotkb:Janusin(gene name synonym)|uniprotkb:Neural recognition molecule J1-160/180(gene name synonym)|uniprotkb:Tnr(gene name)|psi-mi:Tnr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_071707.2|refseq:XP_006496805.1|refseq:XP_006496806.1|refseq:XP_006496807.1|ensembl:ENSMUSG00000015829(gene)|ensembl:ENSMUST00000111669(transcript)|ensembl:ENSMUST00000192069(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0045121"(membrane raft)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048692"(negative regulation of axon extension involved in regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072534"(perineuronal net)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098966"(perisynaptic extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR033079|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:Q8BYI9|reactome:R-MMU-3000178	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:K7s7yPGS4RvIe+thCkAZIFGjNRA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P39447	intact:EBI-645094	intact:EBI-79508|uniprotkb:E9QK00|ensembl:ENSMUSP00000099652	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:zo1_mouse(display_long)|uniprotkb:Tjp1(gene name)|psi-mi:Tjp1(display_short)|uniprotkb:Zo1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005516"(calmodulin binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0005634"(nucleus)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0005737"(cytoplasm)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0005921"(gap junction)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045471"(response to ethanol)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0071000"(response to magnetism)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0071253"(connexin binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:0014704"(intercalated disc)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:0016020"(membrane)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035597|interpro:IPR036028|interpro:IPR036034|mint:P39447|rcsb pdb:2RRM|reactome:R-MMU-191650|reactome:R-MMU-2028269|reactome:R-MMU-351906|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|ensembl:ENSMUSG00000030516(gene)|ensembl:ENSMUST00000102592(transcript)|go:"GO:0001825"(blastocyst formation)|refseq:NP_033412.2|dip:DIP-30946N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:wvslyL15GCrtwUReZEC9DiNvPEk10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9QXE7	intact:EBI-645094	intact:EBI-8821270|ensembl:ENSMUSP00000085549|uniprotkb:Q8BMM0|uniprotkb:Q8BYQ4|uniprotkb:Q8C0A1	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:tbl1x_mouse(display_long)|uniprotkb:Tbl1x(gene name)|psi-mi:Tbl1x(display_short)|uniprotkb:Tbl1(gene name synonym)|uniprotkb:Transducin beta-like protein 1X(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0072686"(mitotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9QXE7|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-9029569|reactome:R-MMU-9707564|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050821"(protein stabilization)|ensembl:ENSMUSG00000025246(gene)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006508"(proteolysis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016575"(histone deacetylation)|ensembl:ENSMUST00000088217(transcript)|refseq:NP_065626.1|refseq:XP_006528002.1|dip:DIP-62055N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:/imB4mxc3ZdNePCeuVI1tpip5YQ10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q60864	intact:EBI-645094	intact:EBI-494437|uniprotkb:Q3TT16|uniprotkb:Q8BPH3|uniprotkb:Q99L66|ensembl:ENSMUSP00000025918	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:stip1_mouse(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:Stip1(gene name)|psi-mi:Stip1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_058017.1|ensembl:ENSMUSG00000024966(gene)|ensembl:ENSMUST00000025918(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043209"(myelin sheath)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR041243|mint:Q60864|reactome:R-MMU-3371497|reactome:R-MMU-9696273	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:f6DTvAcA6tKSLqzw11r9X+rC8ao10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P56873	intact:EBI-645094	intact:EBI-309303|ensembl:ENSMUSP00000025885|ensembl:ENSMUSP00000125570	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:znrd2_mouse(display_long)|uniprotkb:Znrd2(gene name)|psi-mi:Znrd2(display_short)|uniprotkb:Autoantigen p27 homolog(gene name synonym)|uniprotkb:C184l(gene name synonym)|uniprotkb:Protein C184L(gene name synonym)|uniprotkb:Sjoegren syndrome/scleroderma autoantigen 1 homolog(gene name synonym)|uniprotkb:Sssca1(gene name synonym)|uniprotkb:Zinc ribbon domain-containing protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_065237.3|ensembl:ENSMUSG00000079478(gene)|ensembl:ENSMUSG00000118125(gene)|ensembl:ENSMUST00000025885(transcript)|ensembl:ENSMUST00000160852(transcript)|interpro:IPR009563(Sjogrens syndrome scleroderma autoantigen 1)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:/+r9P8t/P3XJd6if3H61qk9H01I10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O54781	intact:EBI-645094	intact:EBI-593325|uniprotkb:Q8VCD9	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:srpk2_mouse(display_long)|uniprotkb:Serine/arginine-rich protein-specific kinase 2(gene name synonym)|uniprotkb:SFRS protein kinase 2(gene name synonym)|uniprotkb:Srpk2(gene name)|psi-mi:Srpk2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	mint:O54781|refseq:NP_033300.2|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|refseq:XP_017176258.1|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000785"(chromatin)|go:"GO:0001525"(angiogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:w16BWU5PrwNUPMC4Yw83eDldbrA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q62261	intact:EBI-645094	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6NZL0	intact:EBI-645094	intact:EBI-776265|uniprotkb:Q8BLM2|uniprotkb:Q9CSN3|uniprotkb:Q9CU45|ensembl:ENSMUSP00000090293	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:soga3_mouse(display_long)|uniprotkb:Soga3(gene name)|psi-mi:Soga3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_080414.2|ensembl:ENSMUSG00000038916(gene)|ensembl:ENSMUST00000092629(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|interpro:IPR027881	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:fqFLavYLqmaqDCGT+/GaB6l9h9U10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q3UHU5	intact:EBI-645094	intact:EBI-16728327|ensembl:ENSMUSP00000083899|uniprotkb:Q6PAM2|uniprotkb:Q80TR7	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:mtcl1_mouse(display_long)|uniprotkb:Coiled-coil domain-containing protein 165(gene name synonym)|uniprotkb:PAR-1-interacting protein(gene name synonym)|uniprotkb:SOGA family member 2(gene name synonym)|uniprotkb:Mtcl1(gene name)|psi-mi:Mtcl1(display_short)|uniprotkb:Ccdc165(gene name synonym)|uniprotkb:Kiaa0802(gene name synonym)|uniprotkb:Soga2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000052105(gene)|ensembl:ENSMUST00000086693(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008017"(microtubule binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0097427"(microtubule bundle)|go:"GO:2000576"(obsolete positive regulation of microtubule motor activity)|interpro:IPR027881|interpro:IPR027882|refseq:NP_001107570.1|refseq:NP_766551.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:vA92FlKEyzd63vdXH/JZpWC7O7410090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:A2AQ25	intact:EBI-645094	intact:EBI-8821027|ensembl:ENSMUSP00000066170|uniprotkb:A2AUE9|uniprotkb:A2AUF0|uniprotkb:A2AUF1|uniprotkb:Q75UV8|uniprotkb:Q75UV9|uniprotkb:Q80VK2|uniprotkb:Q8BHX8|uniprotkb:Q8BHY1|uniprotkb:Q8CHA8|uniprotkb:Q8R0K6	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:skt_mouse(display_long)|uniprotkb:Skt(gene name)|psi-mi:Skt(display_short)|uniprotkb:Etl4(gene name synonym)|uniprotkb:Kiaa1217(gene name synonym)|uniprotkb:Enhancer trap locus 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	interpro:IPR022782|interpro:IPR026725|mint:A2AQ25|ensembl:ENSMUSG00000036617(gene)|ensembl:ENSMUST00000066509(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0048706"(embryonic skeletal system development)|refseq:NP_001074475.1|refseq:NP_001171101.2|refseq:NP_084171.2|refseq:NP_835160.2|refseq:XP_006497478.1|refseq:XP_006497487.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:WI45C2F/GFoa1PhVnBHPtxCj5mM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6P4S6	intact:EBI-645094	intact:EBI-2931619|uniprotkb:Q641L5|uniprotkb:Q66JZ5|uniprotkb:Q6ZQ09|uniprotkb:Q8K075|uniprotkb:Q9CYD5	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:sik3_mouse(display_long)|uniprotkb:Sik3(gene name)|psi-mi:Sik3(display_short)|uniprotkb:Kiaa0999(gene name synonym)|uniprotkb:Qsk(gene name synonym)|uniprotkb:Salt-inducible kinase 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase QSK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001958"(endochondral ossification)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|refseq:NP_081774.3|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR034672	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:eIUTh+NVsTk8OSsys+A7gFfS9AM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P58801	intact:EBI-645094	intact:EBI-15565158|ensembl:ENSMUSP00000038833	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ripk2_mouse(display_long)|uniprotkb:Ripk2(gene name)|psi-mi:Ripk2(display_short)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0070673"(response to interleukin-18)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|reactome:R-MMU-168638|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5689896|reactome:R-MMU-9020702|ensembl:ENSMUSG00000041135(gene)|ensembl:ENSMUST00000037035(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|refseq:NP_620402.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:QmvlF8wotovBBFsfzPVjJ/2HIpE10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P69566	intact:EBI-645094	intact:EBI-772305|uniprotkb:P84500|uniprotkb:Q3V136	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ranb9_mouse(display_long)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:B-cell antigen receptor Ig beta-associated protein 1(gene name synonym)|uniprotkb:Ranbp9(gene name)|psi-mi:Ranbp9(display_short)|uniprotkb:Ranbpm(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_064314.2|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|mint:P69566|interpro:IPR035782|interpro:IPR043136|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-MMU-373760|reactome:R-MMU-5673001|reactome:R-MMU-8851805	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:nKjsQ+KN8Z4mWEyQcRejUCLSDJY10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P70388	intact:EBI-645094	intact:EBI-2014834|uniprotkb:Q6PEB0|uniprotkb:Q8C2T7|uniprotkb:Q9CU59	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:rad50_mouse(display_long)|uniprotkb:Rad50(gene name)|psi-mi:Rad50(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	dip:DIP-46805N|mint:P70388|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0016234"(inclusion body)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045120"(pronucleus)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051276"(chromosome organization)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR004584(Recombination/repair protein Rad50)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|reactome:R-MMU-2559586|reactome:R-MMU-5685938|reactome:R-MMU-5685939|reactome:R-MMU-5685942|reactome:R-MMU-5693548|reactome:R-MMU-5693565|reactome:R-MMU-5693568|reactome:R-MMU-5693571|reactome:R-MMU-5693579|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-6804756|reactome:R-MMU-69473	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:voPf6Nai/iYm8cP2gmGVf8SfqL410090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O35295	intact:EBI-645094	intact:EBI-647544|ensembl:ENSMUSP00000136957	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:purb_mouse(display_long)|uniprotkb:Purine-rich element-binding protein B(gene name synonym)|uniprotkb:Vascular actin single-stranded DNA-binding factor 2 p44 component(gene name synonym)|uniprotkb:Purb(gene name)|psi-mi:Purb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0030154"(cell differentiation)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSMUSG00000094483(gene)|ensembl:ENSMUST00000179343(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|refseq:NP_035351.1|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030499|mint:O35295	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:ZeoADmerELfkQ00oZ1w7a+wgQeA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P42669	intact:EBI-645094	intact:EBI-773823|ensembl:ENSMUSP00000059404	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:pura_mouse(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:Pura(gene name)|psi-mi:Pura(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_033015.1|refseq:XP_006525787.1|refseq:XP_011245162.1|ensembl:ENSMUSG00000043991(gene)|ensembl:ENSMUST00000051301(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:P42669	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:3LVZ5qdZYeJyeUVPhy3cozxROWs10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q3TLH4	intact:EBI-645094	intact:EBI-6908845|ensembl:ENSMUSP00000138433|uniprotkb:E9QKG5|uniprotkb:Q05CS4|uniprotkb:Q05DM5|uniprotkb:Q3TKF3|uniprotkb:Q3UXU5|uniprotkb:Q4FZE4|uniprotkb:Q66K03|uniprotkb:Q6P3F4|uniprotkb:Q80TK3|uniprotkb:Q80YR0|uniprotkb:Q8BMJ4|uniprotkb:Q8C1K7|uniprotkb:Q8CGH3	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:prc2c_mouse(display_long)|uniprotkb:Prrc2c(gene name)|psi-mi:Prrc2c(display_short)|uniprotkb:Bat2d(gene name synonym)|uniprotkb:Bat2d1(gene name synonym)|uniprotkb:Bat2l2(gene name synonym)|uniprotkb:Kiaa1096(gene name synonym)|uniprotkb:BAT2 domain-containing protein 1(gene name synonym)|uniprotkb:HLA-B-associated transcript 2-like 2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:XP_011237086.1|ensembl:ENSMUSG00000040225(gene)|ensembl:ENSMUST00000182660(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q3TLH4|refseq:NP_001074759.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:lJHI4KKm0yJpyg2mURs2zCXOrSY10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q7TPM1	intact:EBI-645094	intact:EBI-16728307|ensembl:ENSMUSP00000035734|uniprotkb:A2AN31|uniprotkb:Q8C755	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:prc2b_mouse(display_long)|uniprotkb:HLA-B-associated transcript 2-like 1(gene name synonym)|uniprotkb:Proline-rich coiled-coil protein 2B(gene name synonym)|uniprotkb:Prrc2b(gene name)|psi-mi:Prrc2b(display_short)|uniprotkb:Bat2l(gene name synonym)|uniprotkb:Bat2l1(gene name synonym)|uniprotkb:Kiaa0515(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000039262(gene)|ensembl:ENSMUST00000036691(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q7TPM1|refseq:NP_001153106.1|refseq:NP_766249.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:WlCA3MFhuVeSWOib983JRtCgwRI10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q7TSC1	intact:EBI-645094	intact:EBI-645425|uniprotkb:Q923A9|uniprotkb:Q9Z1R1|ensembl:ENSMUSP00000025253	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:prc2a_mouse(display_long)|uniprotkb:HLA-B-associated transcript 2(gene name synonym)|uniprotkb:Prrc2a(gene name)|psi-mi:Prrc2a(display_short)|uniprotkb:Bat2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001185973.1|refseq:NP_064411.2|refseq:XP_006524683.1|dip:DIP-49629N|ensembl:ENSMUSG00000024393(gene)|ensembl:ENSMUST00000025253(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q7TSC1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:ktwyGkClOoaD4rZap/xJb/aKj4s10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q62101	intact:EBI-645094	intact:EBI-6903636|uniprotkb:E9QNA3|ensembl:ENSMUSP00000002765	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kpcd1_mouse(display_long)|uniprotkb:Prkd1(gene name)|psi-mi:Prkd1(display_short)|uniprotkb:Pkcm(gene name synonym)|uniprotkb:Pkd(gene name synonym)|uniprotkb:Prkcm(gene name synonym)|uniprotkb:Protein kinase C mu type(gene name synonym)|uniprotkb:Protein kinase D(gene name synonym)|uniprotkb:nPKC-D1(gene name synonym)|uniprotkb:nPKC-mu(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000002688(gene)|ensembl:ENSMUST00000002765(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045087"(innate immune response)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0089700"(protein kinase D signaling)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015727(Protein kinase C mu-related)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|reactome:R-MMU-1660661|refseq:NP_032884.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:xK0iuWlHzuSTL3EQK0HGc2YPjdI10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P63318	intact:EBI-645094	intact:EBI-397096|uniprotkb:P05697|ensembl:ENSMUSP00000097874	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kpcg_mouse(display_long)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_035232.1|ensembl:ENSMUSG00000078816(gene)|ensembl:ENSMUST00000100301(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0005829"(cytosol)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|interpro:IPR020454|interpro:IPR035892|mint:P63318|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-416993|reactome:R-MMU-5099900|reactome:R-MMU-76005	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P68404	intact:EBI-645094	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q76MZ3	intact:EBI-645094	intact:EBI-400413|ensembl:ENSMUSP00000007708	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:2aaa_mouse(display_long)|uniprotkb:Ppp2r1a(gene name)|psi-mi:Ppp2r1a(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_058587.1|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:Q76MZ3|rcsb pdb:2IAE|rcsb pdb:2PF4|rcsb pdb:3FGA|rcsb pdb:6EF4|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2995383|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-975957|ensembl:ENSMUSG00000007564(gene)|ensembl:ENSMUST00000007708(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051232"(meiotic spindle elongation)|dip:DIP-29429N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:0tnO11U1SNOOT46j23f7dim8O8k10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q68FH0	intact:EBI-645094	intact:EBI-16728261|ensembl:ENSMUSP00000099815|uniprotkb:A2AS46|uniprotkb:Q640N0|uniprotkb:Q68G56|uniprotkb:Q8BK47|uniprotkb:Q8BVH1|uniprotkb:Q9CRE3	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:pkp4_mouse(display_long)|uniprotkb:Armadillo-related protein(gene name synonym)|uniprotkb:Pkp4(gene name)|psi-mi:Pkp4(display_short)|uniprotkb:Armrp(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000026991(gene)|ensembl:ENSMUST00000102754(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0030496"(midbody)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|interpro:IPR028443|reactome:R-MMU-6805567|reactome:R-MMU-6809371|reactome:R-MMU-9696264|reactome:R-MMU-9696270|reactome:R-MMU-9696273|refseq:NP_080637.1|refseq:NP_780673.2|refseq:XP_006499234.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:OveWBfDD8W/RHcrE3K4AuVEXBSo10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q922S4	intact:EBI-645094	intact:EBI-772547|uniprotkb:Q8K2U1|uniprotkb:Q3TCR8|uniprotkb:Q3TXZ6|ensembl:ENSMUSP00000131553	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:pde2a_mouse(display_long)|uniprotkb:Cyclic GMP-stimulated phosphodiesterase(gene name synonym)|uniprotkb:Pde2a(gene name)|psi-mi:Pde2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001137321.1|refseq:XP_006507590.1|refseq:NP_001137320.1|ensembl:ENSMUSG00000110195(gene)|ensembl:ENSMUST00000163751(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004118"(cGMP-stimulated cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010749"(regulation of nitric oxide mediated signal transduction)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0035904"(aorta development)|go:"GO:0036004"(GAF domain binding)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:1904613"(cellular response to 2,3,7,8-tetrachlorodibenzodioxine)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|mint:Q922S4|rcsb pdb:1MC0|reactome:R-MMU-418457|reactome:R-MMU-418555	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:Mb4AbU3k9lQ/qLUITe5AJ1NZdk810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P48725	intact:EBI-645094	intact:EBI-2290976|uniprotkb:A0JBT0|uniprotkb:A0JBT1	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:pcnt_mouse(display_long)|uniprotkb:Pcnt(gene name)|psi-mi:Pcnt(display_short)|uniprotkb:Pcnt2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001269921.1|refseq:NP_032813.3|interpro:IPR019528|interpro:IPR028745|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-9646399|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001944"(vasculature development)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007165"(signal transduction)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0060322"(head development)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:1990403"(embryonic brain development)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:1uo9aCCB8laEBPn83Udu0EY2wco10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O08919	intact:EBI-645094	intact:EBI-773000|uniprotkb:Q4QQQ2|uniprotkb:Q6NVG8|ensembl:ENSMUSP00000078245	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:numbl_mouse(display_long)|uniprotkb:Numbl(gene name)|psi-mi:Numbl(display_short)|uniprotkb:Nbl(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_035080.2|ensembl:ENSMUSG00000063160(gene)|ensembl:ENSMUST00000079258(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007409"(axonogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019538"(protein metabolic process)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021849"(neuroblast division in subventricular zone)|go:"GO:0030900"(forebrain development)|go:"GO:0034332"(adherens junction organization)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:2qFX1x26D9ZwQAsK/wDEwyevlD410090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P46460	intact:EBI-645094	intact:EBI-398006|uniprotkb:A2A646|uniprotkb:Q8BQ65|uniprotkb:Q8C3R2|uniprotkb:Q8CCT9|uniprotkb:Q8CEF0|uniprotkb:Q923C6|ensembl:ENSMUSP00000099364	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:nsf_mouse(display_long)|uniprotkb:Nsf(gene name)|psi-mi:Nsf(display_short)|uniprotkb:Skd2(gene name synonym)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 2"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_032766.2|ensembl:ENSMUSG00000034187(gene)|ensembl:ENSMUST00000103075(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46460|reactome:R-MMU-204005|reactome:R-MMU-416993|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811438|reactome:R-MMU-6811440	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:mqNfvBVWEdD4caFZug82c88vwE410090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P08551	intact:EBI-645094	intact:EBI-445199|uniprotkb:Q8K0Z0|ensembl:ENSMUSP00000022639	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:nfl_mouse(display_long)|uniprotkb:Neurofilament triplet L protein(gene name synonym)|uniprotkb:68 kDa neurofilament protein(gene name synonym)|uniprotkb:Nefl(gene name)|psi-mi:Nefl(display_short)|uniprotkb:Nfl(gene name synonym)|uniprotkb:Nf68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_035040.1|ensembl:ENSMUSG00000022055(gene)|ensembl:ENSMUST00000022639(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027692|interpro:IPR039008|mint:P08551|reactome:R-MMU-438066|reactome:R-MMU-5673001|go:"GO:0098981"(cholinergic synapse)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0040011"(locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051258"(protein polymerization)|go:"GO:0051412"(response to corticosterone)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060074"(synapse maturation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|dip:DIP-31944N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:E8KK2ppZXyLXIlFZp/pjXv7GBEU10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9WU42	intact:EBI-645094	intact:EBI-6673326|ensembl:ENSMUSP00000107029|uniprotkb:E9Q9V0|uniprotkb:Q9WU43|uniprotkb:Q9WUC1	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ncor2_mouse(display_long)|uniprotkb:Ncor2(gene name)|psi-mi:Ncor2(display_short)|uniprotkb:Smrt(gene name synonym)|uniprotkb:Silencing mediator of retinoic acid and thyroid hormone receptor(gene name synonym)|uniprotkb:T3 receptor-associating factor(gene name synonym)|uniprotkb:Thyroid-, retinoic-acid-receptor-associated corepressor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:Q9WU42|reactome:R-MMU-2173795|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-383280|reactome:R-MMU-400206|reactome:R-MMU-9029569|reactome:R-MMU-9623433|reactome:R-MMU-9707564|ensembl:ENSMUSG00000029478(gene)|ensembl:ENSMUST00000111398(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021537"(telencephalon development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0030900"(forebrain development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:XP_011239133.1|refseq:NP_001240833.1|refseq:NP_001240834.1|dip:DIP-42595N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:/OTDXDBeSGySNf9Sfg/BDtf8FDA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q60974	intact:EBI-645094	intact:EBI-349004|uniprotkb:Q60812	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ncor1_mouse(display_long)|uniprotkb:Ncor1(gene name)|psi-mi:Ncor1(display_short)|uniprotkb:Rxrip13(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0002361"(CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021794"(thalamus development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051225"(spindle assembly)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:0046329"(negative regulation of JNK cascade)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|reactome:R-MMU-2173795|reactome:R-MMU-3214815|reactome:R-MMU-350054|go:"GO:0046965"(retinoid X receptor binding)|reactome:R-MMU-383280|reactome:R-MMU-9029569|reactome:R-MMU-9623433|reactome:R-MMU-9707564|reactome:R-MMU-400206|mint:Q60974|dip:DIP-32548N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:5IfmxD5K9s0dYCZ6AOMwaBDElFs10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O09000	intact:EBI-645094	intact:EBI-3508338|uniprotkb:Q9CRD5	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ncoa3_mouse(display_long)|uniprotkb:Ncoa3(gene name)|psi-mi:Ncoa3(display_short)|uniprotkb:Aib1(gene name synonym)|uniprotkb:Pcip(gene name synonym)|uniprotkb:Rac3(gene name synonym)|uniprotkb:Tram1(gene name synonym)|uniprotkb:Amplified in breast cancer-1 protein homolog(gene name synonym)|uniprotkb:CBP-interacting protein(gene name synonym)|uniprotkb:Receptor-associated coactivator 3(gene name synonym)|uniprotkb:Steroid receptor coactivator protein 3(gene name synonym)|uniprotkb:Thyroid hormone receptor activator molecule 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028818|interpro:IPR032565|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|reactome:R-MMU-5687128|reactome:R-MMU-9018519|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1902459"(positive regulation of stem cell population maintenance)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033145"(positive regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048589"(developmental growth)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060068"(vagina development)|go:"GO:0060713"(labyrinthine layer morphogenesis)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0072091"(regulation of stem cell proliferation)|dip:DIP-44921N|mint:O09000	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:kUBr4kzfOKOmyqLPHkFpp4vQQ5s10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P28660	intact:EBI-645094	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8VE19	intact:EBI-645094	intact:EBI-16728240|ensembl:ENSMUSP00000039301|uniprotkb:E9QM00	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:mio_mouse(display_long)|uniprotkb:Mios(gene name)|psi-mi:Mios(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	interpro:IPR036322|interpro:IPR037593|mint:Q8VE19|reactome:R-MMU-9639288|ensembl:ENSMUSG00000042447(gene)|ensembl:ENSMUST00000040017(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|refseq:NP_663349.2|refseq:XP_006505149.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:Ib8ROrOPZeyTPcH80k1OiKYT2vw10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:E9PWI3	intact:EBI-645094	intact:EBI-16728216|ensembl:ENSMUSP00000087318	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:e9pwi3_mouse(display_long)|uniprotkb:Mcc(gene name)|psi-mi:Mcc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000071856(gene)|ensembl:ENSMUST00000089874(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR019536|interpro:IPR040171|refseq:NP_001078842.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:O1tiRrIkuo7poldZ1B6gOsZsYRA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8K310	intact:EBI-645094	intact:EBI-1216295|ensembl:ENSMUSP00000125761|ensembl:ENSMUSP00000158074|ensembl:ENSMUSP00000158537	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:matr3_mouse(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_034901.2|rcsb pdb:1X4F|rcsb pdb:1X4D|ensembl:ENSMUSG00000037236(gene)|ensembl:ENSMUST00000166793(transcript)|ensembl:ENSMUST00000235199(transcript)|ensembl:ENSMUST00000237744(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:Q8K310	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:AwtFbI+oRfha+mn/v3yzG6bNXYg10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P63085	intact:EBI-645094	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q91ZX7	intact:EBI-645094	intact:EBI-300955|uniprotkb:Q61291|uniprotkb:Q920Y4	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:lrp1_mouse(display_long)|uniprotkb:Lrp1(gene name)|psi-mi:Lrp1(display_short)|uniprotkb:Alpha-2-macroglobulin receptor(gene name synonym)|uniprotkb:A2mr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	mint:Q91ZX7|go:"GO:0002020"(protease binding)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016964"(alpha-2 macroglobulin receptor activity)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032370"(positive regulation of lipid transport)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904300"(positive regulation of transcytosis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR032485|interpro:IPR036055|reactome:R-MMU-2168880|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048694"(positive regulation of collateral sprouting of injured axon)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0045807"(positive regulation of endocytosis)|reactome:R-MMU-975634|refseq:NP_032538.2|dip:DIP-47785N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:lX7IFHEMgDZnvC069QGK9D4BL1Y10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q7TME0	intact:EBI-645094	intact:EBI-773446|uniprotkb:Q8BV73|uniprotkb:Q8BXK2|uniprotkb:Q8R3R6|uniprotkb:Q6ZQA8|uniprotkb:B2RQ15|ensembl:ENSMUSP00000052306	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:plpr4_mouse(display_long)|uniprotkb:Plppr4(gene name)|psi-mi:Plppr4(display_short)|uniprotkb:Brain-specific phosphatidic acid phosphatase-like protein 1(gene name synonym)|uniprotkb:D3Bwg0562e(gene name synonym)|uniprotkb:Kiaa0455(gene name synonym)|uniprotkb:Lipid phosphate phosphatase-related protein type 4(gene name synonym)|uniprotkb:Lppr4(gene name synonym)|uniprotkb:Php1(gene name synonym)|uniprotkb:Plasticity-related gene 1 protein(gene name synonym)|uniprotkb:Prg1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_808332.3|ensembl:ENSMUSG00000044667(gene)|ensembl:ENSMUST00000061071(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008195"(phosphatidate phosphatase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0042577"(lipid phosphatase activity)|go:"GO:0046839"(phospholipid dephosphorylation)|go:"GO:0048839"(inner ear development)|go:"GO:0052642"(lysophosphatidic acid phosphatase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|interpro:IPR000326(Phosphatidic acid phosphatase type 2/haloperoxidase)|interpro:IPR028684|interpro:IPR036938|interpro:IPR043216|mint:Q7TME0|reactome:R-MMU-419408	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:fY903zOXq+XLdNeiGse0KCznPD810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8BZL8	intact:EBI-645094	intact:EBI-16728185|ensembl:ENSMUSP00000124862|ensembl:ENSMUSP00000125335|ensembl:ENSMUSP00000125589|ensembl:ENSMUSP00000145048	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:lmo3_mouse(display_long)|uniprotkb:Neuronal-specific transcription factor DAT1(gene name synonym)|uniprotkb:Lmo3(gene name)|psi-mi:Lmo3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000030226(gene)|ensembl:ENSMUST00000161450(transcript)|ensembl:ENSMUST00000162772(transcript)|ensembl:ENSMUST00000163024(transcript)|ensembl:ENSMUST00000203435(transcript)|go:"GO:0046872"(metal ion binding)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_997105.1|refseq:XP_006505403.1|refseq:XP_006505404.1|refseq:XP_006505405.1|refseq:XP_006505407.1|refseq:XP_011239433.1|refseq:XP_011239434.1|refseq:XP_011239435.1|refseq:XP_017176802.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:cZJuQ9JWbTbuABfiuU3iIRoMWhc10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O55203	intact:EBI-645094	intact:EBI-15657830|ensembl:ENSMUSP00000067737|uniprotkb:O55205|uniprotkb:Q3UHY1|uniprotkb:Q6AXE6	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ldb2_mouse(display_long)|uniprotkb:Ldb2(gene name)|psi-mi:Ldb2(display_short)|uniprotkb:Clim1(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 1(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000039706(gene)|ensembl:ENSMUST00000070748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001942"(hair follicle development)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0044089"(positive regulation of cellular component biogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR029005|interpro:IPR030174|interpro:IPR041363|refseq:NP_001070866.1|refseq:NP_001273277.1|refseq:NP_034828.3|refseq:XP_006503817.1|refseq:XP_006503819.1|dip:DIP-46444N	-	-	"mimix:comment":not sure if in every case the origin is the same	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:BGyRj6BxhHIZzkK7TNBi769iu4U10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P70662	intact:EBI-645094	intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O88447	intact:EBI-645094	intact:EBI-301550	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:klc1_mouse(display_long)|uniprotkb:Klc1(gene name)|psi-mi:Klc1(display_short)|uniprotkb:Kns2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	mint:O88447|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043227"(membrane-bounded organelle)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|rcsb pdb:6FUZ|rcsb pdb:6FV0|reactome:R-MMU-2132295|reactome:R-MMU-5625970|reactome:R-MMU-6811434|reactome:R-MMU-983189|dip:DIP-31520N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:YFYhenefPpzqNvaDB3e6plPlGQo10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P28738	intact:EBI-645094	intact:EBI-2506834|uniprotkb:Q6NXI9|ensembl:ENSMUSP00000028102|uniprotkb:Q9Z2F8	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kif5c_mouse(display_long)|uniprotkb:Kif5c(gene name)|psi-mi:Kif5c(display_short)|uniprotkb:Nkhc2(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000026764(gene)|ensembl:ENSMUST00000028102(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051028"(mRNA transport)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098964"(anterograde dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0150034"(distal axon)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:P28738|rcsb pdb:1VFV|rcsb pdb:1VFW|rcsb pdb:1VFX|rcsb pdb:1VFZ|rcsb pdb:3J6H|rcsb pdb:3WRD|rcsb pdb:3X2T|rcsb pdb:5HLE|refseq:NP_032475.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:GbPyKDztqPG8BP2+44k3TXPuI/010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q61768	intact:EBI-645094	intact:EBI-776129|uniprotkb:Q5BL10|uniprotkb:O08711|uniprotkb:Q61580|ensembl:ENSMUSP00000025083	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kinh_mouse(display_long)|uniprotkb:Ubiquitous kinesin heavy chain(gene name synonym)|uniprotkb:Conventional kinesin heavy chain(gene name synonym)|uniprotkb:Kif5b(gene name)|psi-mi:Kif5b(display_short)|uniprotkb:Khcs(gene name synonym)|uniprotkb:Kns1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_032474.2|dip:DIP-32053N|ensembl:ENSMUSG00000006740(gene)|ensembl:ENSMUST00000025083(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0021766"(hippocampus development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032418"(lysosome localization)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072383"(plus-end-directed vesicle transport along microtubule)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099609"(microtubule lateral binding)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905152"(positive regulation of voltage-gated sodium channel activity)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q61768|rcsb pdb:6IGN|rcsb pdb:6IGV|reactome:R-MMU-2132295|reactome:R-MMU-5625970|reactome:R-MMU-6811434|reactome:R-MMU-983189	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:11aePhwWZOqqAabjyanVgdHQQso10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P33175	intact:EBI-645094	intact:EBI-349710|uniprotkb:Q5DTP1|uniprotkb:Q6PDY7|uniprotkb:Q9Z2F9|ensembl:ENSMUSP00000096775|ensembl:ENSMUSP00000151402	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kif5a_mouse(display_long)|uniprotkb:Kif5a(gene name)|psi-mi:Kif5a(display_short)|uniprotkb:Kiaa4086(gene name synonym)|uniprotkb:Kif5(gene name synonym)|uniprotkb:Neuronal kinesin heavy chain(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 1(gene name synonym)|uniprotkb:Nkhc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001034089.1|refseq:NP_032473.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P33175|reactome:R-MMU-2132295|reactome:R-MMU-5625970|reactome:R-MMU-6811434|reactome:R-MMU-983189|ensembl:ENSMUSG00000074657(gene)|ensembl:ENSMUST00000099172(transcript)|ensembl:ENSMUST00000217895(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:otK0LxjRwOuSLqL6iOEI+7BY+SI10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P28740	intact:EBI-645094	intact:EBI-776122|uniprotkb:O54744|uniprotkb:Q91W03|ensembl:ENSMUSP00000022204	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kif2a_mouse(display_long)|uniprotkb:Kif2a(gene name)|psi-mi:Kif2a(display_short)|uniprotkb:Kif2(gene name synonym)|uniprotkb:Kns2(gene name synonym)|uniprotkb:Kinesin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001139251.1|refseq:XP_006517602.1|ensembl:ENSMUSG00000021693(gene)|ensembl:ENSMUST00000022204(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0051301"(cell division)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097228"(sperm principal piece)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P28740|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-6811434|reactome:R-MMU-68877|reactome:R-MMU-9648025|reactome:R-MMU-983189	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:xPWg0rzeKQooA3AM2Ics+e/QnRM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q3U0V1	intact:EBI-645094	intact:EBI-4282969|uniprotkb:Q2VPQ6|uniprotkb:Q6P2L2|uniprotkb:E9QKH3|ensembl:ENSMUSP00000007814	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:fubp2_mouse(display_long)|uniprotkb:Khsrp(gene name)|psi-mi:Khsrp(display_short)|uniprotkb:Fubp2(gene name synonym)|uniprotkb:KH type-splicing regulatory protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_034743.3|ensembl:ENSMUSG00000007670(gene)|ensembl:ENSMUST00000007814(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0030425"(dendrite)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0051028"(mRNA transport)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR015096(Region of unknown function DUF1897)|interpro:IPR036612|mint:Q3U0V1|reactome:R-MMU-450604	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:snMZYaCxr5k/zzbgZD18vz5RAfs10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q3UXZ9	intact:EBI-645094	intact:EBI-2531441|uniprotkb:Q3TM94|uniprotkb:Q3UMI5|uniprotkb:Q66JZ3|ensembl:ENSMUSP00000005108	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kdm5a_mouse(display_long)|uniprotkb:Kdm5a(gene name)|psi-mi:Kdm5a(display_short)|uniprotkb:Jarid1a(gene name synonym)|uniprotkb:Rbp2(gene name synonym)|uniprotkb:Histone demethylase JARID1A(gene name synonym)|uniprotkb:Jumonji/ARID domain-containing protein 1A(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 2(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(4) demethylase 5A"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034647"(histone H3-tri/di/monomethyl-lysine-4 demethylase activity)|go:"GO:0034648"("obsolete histone demethylase activity (H3-dimethyl-K4 specific)")|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051213"(dioxygenase activity)|go:"GO:1901726"(negative regulation of histone deacetylase activity)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013637(PLU-1-like)|ensembl:ENSMUSG00000030180(gene)|ensembl:ENSMUST00000005108(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032452"(histone demethylase activity)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036431|reactome:R-MMU-3214842|refseq:NP_666109.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:8C0wFfScuniM5xlbNl2gqSHc++U10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6ZPR4	intact:EBI-645094	intact:EBI-16728165|ensembl:ENSMUSP00000109809|uniprotkb:B2RUK3|uniprotkb:Q8C3E7	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kcnt1_mouse(display_long)|uniprotkb:Kcnt1(gene name)|psi-mi:Kcnt1(display_short)|uniprotkb:Kiaa1422(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000058740(gene)|ensembl:ENSMUST00000114172(transcript)|go:"GO:0005228"(intracellular sodium activated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR013099(Ion transport 2)|mint:Q6ZPR4|refseq:NP_001289280.1|refseq:NP_780671.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:dqty8xDH9pIQhzgbYTeSOo4tLjA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q08460	intact:EBI-645094	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8C863	intact:EBI-645094	intact:EBI-851782|uniprotkb:O54971|ensembl:ENSMUSP00000029126|ensembl:ENSMUSP00000105307	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:itch_mouse(display_long)|uniprotkb:Itch(gene name)|psi-mi:Itch(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001230641.1|refseq:NP_032421.2|dip:DIP-29318N|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q8C863|rcsb pdb:1YIU|rcsb pdb:2JO9|rcsb pdb:2JOC|rcsb pdb:5XMC|reactome:R-MMU-1253288|reactome:R-MMU-168638|reactome:R-MMU-2122948|reactome:R-MMU-5610780|reactome:R-MMU-5632684|reactome:R-MMU-8939236|reactome:R-MMU-983168|ensembl:ENSMUSG00000027598(gene)|ensembl:ENSMUST00000029126(transcript)|ensembl:ENSMUST00000109685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:gDN+qYu3L0C2MzekQFRAtVwgceE10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8R0S2	intact:EBI-645094	intact:EBI-772277|uniprotkb:Q3TZC3|uniprotkb:Q5DU15|ensembl:ENSMUSP00000098712	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:iqec1_mouse(display_long)|uniprotkb:Iqsec1(gene name)|psi-mi:Iqsec1(display_short)|uniprotkb:Kiaa0763(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001127855.1|ensembl:ENSMUSG00000034312(gene)|ensembl:ENSMUST00000101153(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR030737|interpro:IPR033742|interpro:IPR035999	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:BZg7CaLndE4ak8KXs34YFf9iBRQ10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P46660	intact:EBI-645094	intact:EBI-400482|uniprotkb:Q61958|uniprotkb:Q8VCW5|ensembl:ENSMUSP00000041347	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ainx_mouse(display_long)|uniprotkb:Ina(gene name)|psi-mi:Ina(display_short)|uniprotkb:66 kDa neurofilament protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_666212.3|ensembl:ENSMUSG00000034336(gene)|ensembl:ENSMUST00000037636(transcript)|go:"GO:0005883"(neurofilament)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027703|interpro:IPR039008|mint:P46660	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:amjP0AajB8s2oXmV96wzyfz6evE10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q60625	intact:EBI-645094	intact:EBI-777635|intact:EBI-2935094|uniprotkb:Q2KHL7|uniprotkb:Q3UY19|ensembl:ENSMUSP00000019616|uniprotkb:G5E826	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:icam5_mouse(display_long)|uniprotkb:Telencephalin(gene name synonym)|uniprotkb:Icam5(gene name)|psi-mi:Icam5(display_short)|uniprotkb:Tlcn(gene name synonym)|uniprotkb:Icam3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	reactome:R-MMU-198933|reactome:R-MMU-216083|ensembl:ENSMUSG00000032174(gene)|ensembl:ENSMUST00000019616(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003988(Intercellular adhesion molecule)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q60625|refseq:NP_032345.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:A5LktyV63FCm8TYD3ChcBoYslPc10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O88895	intact:EBI-645094	intact:EBI-302263|uniprotkb:O88896	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:hdac3_mouse(display_long)|uniprotkb:Hdac3(gene name)|psi-mi:Hdac3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0051020"(GTPase binding)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990679"(histone H4-K12 deacetylation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-9029569|reactome:R-MMU-9707564|dip:DIP-32547N|mint:O88895	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:0dUkbfmVE49cbSiAPqrb7uFN8l010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q91VW5	intact:EBI-645094	intact:EBI-643481|uniprotkb:O70365|uniprotkb:Q8CGH6|ensembl:ENSMUSP00000081880	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:goga4_mouse(display_long)|uniprotkb:tGolgin-1(gene name synonym)|uniprotkb:Golga4(gene name)|psi-mi:Golga4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000038708(gene)|ensembl:ENSMUST00000084820(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0051020"(GTPase binding)|interpro:IPR000237(GRIP)|reactome:R-MMU-6811440|refseq:NP_061218.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:pK5clT3BtNvFt3T/mXdqAHaCmDA10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:A2A699	intact:EBI-645094	intact:EBI-16726238|ensembl:ENSMUSP00000038486|uniprotkb:B7ZC48|uniprotkb:Q05CH6|uniprotkb:Q6P2L1	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:f1712_mouse(display_long)|uniprotkb:Fam171a2(gene name)|psi-mi:Fam171a2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000034685(gene)|ensembl:ENSMUST00000049057(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR018890|refseq:NP_954670.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:7NVAzhDbIF2fudv/6EvN9nU/Ops10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:A2ATK9	intact:EBI-645094	intact:EBI-16728153|ensembl:ENSMUSP00000110751	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:a2atk9_mouse(display_long)|uniprotkb:Fam171a1(gene name)|psi-mi:Fam171a1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000050530(gene)|ensembl:ENSMUST00000115099(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043149"(stress fiber assembly)|interpro:IPR018890|refseq:NP_001074630.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:uKFpL1QJAielqNbG5qRZDnKN5Dk10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8C3F2	intact:EBI-645094	intact:EBI-16728136|ensembl:ENSMUSP00000073082|uniprotkb:Q3U0F6	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:f120c_mouse(display_long)|uniprotkb:Protein FAM120C(gene name synonym)|uniprotkb:Fam120c(gene name)|psi-mi:Fam120c(display_short)|uniprotkb:ORF34(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000025262(gene)|go:"GO:0005634"(nucleus)|interpro:IPR026784|interpro:IPR026785|interpro:IPR029060|mint:Q8C3F2|ensembl:ENSMUST00000073364(transcript)|refseq:NP_932773.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:7t8xHEO+ShbLsdqIbH6xQm7UcPw10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q05BC3	intact:EBI-645094	intact:EBI-16728102|ensembl:ENSMUSP00000105486|uniprotkb:Q05AF8|uniprotkb:Q0P5V3	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:emal1_mouse(display_long)|uniprotkb:Eml1(gene name)|psi-mi:Eml1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000058070(gene)|ensembl:ENSMUST00000109860(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR005108(HELP)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_001036800.1|refseq:NP_001036801.1|refseq:NP_001273275.1|refseq:NP_001273276.1|refseq:XP_017170659.1|refseq:XP_017170661.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:dUO3FYilUuNbROHohGFG/vrz5AE10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P70372	intact:EBI-645094	intact:EBI-6877056|ensembl:ENSMUSP00000096549|ensembl:ENSMUSP00000146866|uniprotkb:Q60745|uniprotkb:Q78QY3	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:elav1_mouse(display_long)|uniprotkb:Elavl1(gene name)|psi-mi:Elavl1(display_short)|uniprotkb:Elra(gene name synonym)|uniprotkb:Hua(gene name synonym)|uniprotkb:Elav-like generic protein(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym)|uniprotkb:MelG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000040028(gene)|ensembl:ENSMUST00000098950(transcript)|ensembl:ENSMUST00000209010(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:P70372|reactome:R-MMU-450520|reactome:R-MMU-72163|go:"GO:0019901"(protein kinase binding)|refseq:XP_006508761.1|refseq:NP_034615.2|dip:DIP-46480N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:iKHrpZqi5b7EFLkfVJSRTpi9sj010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9QXY6	intact:EBI-645094	intact:EBI-775304|uniprotkb:Q8K590|ensembl:ENSMUSP00000024860	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ehd3_mouse(display_long)|uniprotkb:Ehd3(gene name)|psi-mi:Ehd3(display_short)|uniprotkb:Ehd2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_065603.2|ensembl:ENSMUSG00000024065(gene)|ensembl:ENSMUST00000024860(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9QXY6|reactome:R-MMU-983231	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:COp4bL5nQo5RCRHYzQYqtdl4Xjo10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P63168	intact:EBI-645094	intact:EBI-349121|uniprotkb:Q15701|ensembl:ENSMUSP00000107720|ensembl:ENSMUSP00000009157|uniprotkb:Q3UGE7	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dyl1_mouse(display_long)|uniprotkb:Dynll1(gene name)|psi-mi:Dynll1(display_short)|uniprotkb:Dlc1(gene name synonym)|uniprotkb:Dnclc1(gene name synonym)|uniprotkb:Dncl1(gene name synonym)|uniprotkb:Dynein light chain LC8-type 1(gene name synonym)|uniprotkb:8 kDa dynein light chain(gene name synonym)|uniprotkb:Protein inhibitor of neuronal nitric oxide synthase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_062656.3|ensembl:ENSMUST00000009157(transcript)|ensembl:ENSMUST00000112090(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000009013(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006915"(apoptotic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0030141"(secretory granule)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030286"(dynein complex)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|mint:P63168|reactome:R-MMU-111446|reactome:R-MMU-141444|reactome:R-MMU-1632852|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:Bra4LfaqYPMyo6xX9RD6G7Rdv8010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9JHU4	intact:EBI-645094	intact:EBI-645061|uniprotkb:E9QM71|ensembl:ENSMUSP00000018851	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dyhc1_mouse(display_long)|uniprotkb:Dhc1(gene name synonym)|uniprotkb:Dyhc(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:Dync1h1(gene name)|psi-mi:Dync1h1(display_short)|uniprotkb:Dnch1(gene name synonym)|uniprotkb:Dnchc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_084514.2|ensembl:ENSMUSG00000018707(gene)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002177"(manchette)|go:"GO:0003341"(cilium movement)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|ensembl:ENSMUST00000018851(transcript)|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|interpro:IPR042219|mint:Q9JHU4|rcsb pdb:3ERR|rcsb pdb:3J1T|rcsb pdb:3J1U|rcsb pdb:3WUQ|rcsb pdb:5AYH|rcsb pdb:6RZA|rcsb pdb:6RZB|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:sbED0xqQpe32T7I8ijeS3Xqlx7010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O08553	intact:EBI-645094	intact:EBI-446064|uniprotkb:Q6P5D0|ensembl:ENSMUSP00000022629	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dpyl2_mouse(display_long)|uniprotkb:Unc-33-like phosphoprotein 2(gene name synonym)|uniprotkb:Dpysl2(gene name)|psi-mi:Dpysl2(display_short)|uniprotkb:Crmp2(gene name synonym)|uniprotkb:Ulip2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_034085.2|ensembl:ENSMUSG00000022048(gene)|ensembl:ENSMUST00000022629(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043209"(myelin sheath)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098793"(presynapse)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030615|interpro:IPR032466|mint:O08553|rcsb pdb:5UQC|reactome:R-MMU-399956|reactome:R-MMU-437239	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:97yc8TNEPMcGtGNRLvl+KV+DYr010090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P39053	intact:EBI-645094	intact:EBI-397785|ensembl:ENSMUSP00000122679|uniprotkb:A2AN50|uniprotkb:A2AN51|uniprotkb:A2AN54|uniprotkb:A2AN55|uniprotkb:Q3UNM1|uniprotkb:Q5DTN7|uniprotkb:Q61358|uniprotkb:Q61359|uniprotkb:Q61360|uniprotkb:Q6PDM5|uniprotkb:Q8JZZ4|uniprotkb:Q9CSY7|uniprotkb:Q9QXX1	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dyn1_mouse(display_long)|uniprotkb:Dnm1(gene name)|psi-mi:Dnm1(display_short)|uniprotkb:Dnm(gene name synonym)|uniprotkb:Kiaa4093(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_034195.2|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:P39053|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|ensembl:ENSMUSG00000026825(gene)|ensembl:ENSMUST00000139624(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904645"(response to amyloid-beta)|refseq:NP_001288666.1|refseq:XP_006497721.2|refseq:XP_006497722.2|refseq:XP_006497723.2|refseq:XP_006497724.2|refseq:XP_006497718.2|refseq:XP_017170817.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:wtPz3gwyxU6tAgh5091LQpt099I10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q3UH60	intact:EBI-645094	intact:EBI-16724475|ensembl:ENSMUSP00000097777|uniprotkb:Q8C1W5|uniprotkb:Q8CDG9|uniprotkb:Q8CHA2	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dip2b_mouse(display_long)|uniprotkb:Dip2b(gene name)|psi-mi:Dip2b(display_short)|uniprotkb:Kiaa1463(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000023026(gene)|ensembl:ENSMUST00000100203(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR010506(DMAP1-binding)|interpro:IPR037337|interpro:IPR042099|mint:Q3UH60|refseq:NP_001152833.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:fgjJT8HpeVRm1osKj8p2Dx7WxU810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O70566	intact:EBI-645094	intact:EBI-12601005|ensembl:ENSMUSP00000108946|uniprotkb:Q8C2G8	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:diap2_mouse(display_long)|uniprotkb:Diaph2(gene name)|psi-mi:Diaph2(display_short)|uniprotkb:Diap2(gene name synonym)|uniprotkb:Diaphanous-related formin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000034480(gene)|ensembl:ENSMUST00000113320(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0048477"(oogenesis)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027644|interpro:IPR042201|reactome:R-MMU-5663220|reactome:R-MMU-9013405|reactome:R-MMU-9035034|refseq:XP_006528645.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:Ijh6AnLTTDRtvFNXgA0eQzoT3ug10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O54784	intact:EBI-645094	intact:EBI-77359|ensembl:ENSMUSP00000035962|ensembl:ENSMUSP00000137333|ensembl:ENSMUSP00000151577	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:dapk3_mouse(display_long)|uniprotkb:Dapk3(gene name)|psi-mi:Dapk3(display_short)|uniprotkb:Zipk(gene name synonym)|uniprotkb:DAP-like kinase(gene name synonym)|uniprotkb:ZIP-kinase(gene name synonym)|uniprotkb:MYPT1 kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001177402.1|refseq:NP_031854.1|refseq:XP_006513258.1|ensembl:ENSMUSG00000034974(gene)|ensembl:ENSMUST00000047665(transcript)|ensembl:ENSMUST00000178422(transcript)|ensembl:ENSMUST00000219850(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005884"(actin filament)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016301"(kinase activity)|go:"GO:0016605"(PML body)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043519"(regulation of myosin II filament organization)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042870	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:LOZoxWuCRZi1kVZyrtoEijElfC810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q5SQX6	intact:EBI-645094	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q02248	intact:EBI-645094	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q0V8T9	intact:EBI-645094	intact:EBI-16728079|ensembl:ENSMUSP00000035732	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ctp5a_mouse(display_long)|uniprotkb:Cell recognition molecule Caspr5-1(gene name synonym)|uniprotkb:Cell recognition molecule Caspr5a(gene name synonym)|uniprotkb:Contactin-associated protein-like 5a(gene name synonym)|uniprotkb:Cntnap5a(gene name)|psi-mi:Cntnap5a(display_short)|uniprotkb:Caspr5-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR028874|interpro:IPR036056|ensembl:ENSMUSG00000070695(gene)|ensembl:ENSMUST00000043725(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|refseq:NP_001070893.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:hhEPNGI1jHPvgfgvgGei7+IuYyk10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P12960	intact:EBI-645094	intact:EBI-774808|uniprotkb:Q6NXV7|uniprotkb:Q8BR42|uniprotkb:Q8C6A0|ensembl:ENSMUSP00000000109|ensembl:ENSMUSP00000067842|ensembl:ENSMUSP00000133063	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:cntn1_mouse(display_long)|uniprotkb:Neural cell surface protein F3(gene name synonym)|uniprotkb:Cntn1(gene name)|psi-mi:Cntn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001153119.1|refseq:NP_001153120.1|refseq:NP_031753.1|refseq:XP_017171911.1|ensembl:ENSMUSG00000055022(gene)|ensembl:ENSMUST00000000109(transcript)|ensembl:ENSMUST00000068378(transcript)|ensembl:ENSMUST00000169825(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0021549"(cerebellum development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099026"(anchored component of presynaptic membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR036992|mint:P12960	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:TftNvfwJlK/7DTczqiV/IzDxhOM10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6ZQ08	intact:EBI-645094	intact:EBI-682479|intact:EBI-2104684|uniprotkb:B2RY28|uniprotkb:Q3UPB7|uniprotkb:Q8BSB4|uniprotkb:Q8BXB2|uniprotkb:Q8C0H2|uniprotkb:Q8K3D8	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:cnot1_mouse(display_long)|uniprotkb:Cnot1(gene name)|psi-mi:Cnot1(display_short)|uniprotkb:Kiaa1007(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_835179.1|refseq:XP_006530937.1|dip:DIP-46845N|mint:Q6ZQ08|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|reactome:R-MMU-429947|reactome:R-MMU-6804115	-	-	comment:AfCS Y2H protein 39306. Translated from nucleotide sequence.	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:2Q4quoSuPlUbD4QkiAkc9Hr9avI10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q80U49	intact:EBI-645094	intact:EBI-16728053|ensembl:ENSMUSP00000098580|ensembl:ENSMUSP00000137331|ensembl:ENSMUSP00000152451|uniprotkb:Q3UH33|uniprotkb:Q3UHG1|uniprotkb:Q80UM2	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:c170b_mouse(display_long)|uniprotkb:Centrosomal protein 170B(gene name synonym)|uniprotkb:Cep170b(gene name)|psi-mi:Cep170b(display_short)|uniprotkb:Kiaa0284(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000072825(gene)|ensembl:ENSMUST00000101018(transcript)|ensembl:ENSMUST00000179041(transcript)|ensembl:ENSMUST00000222711(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029300|refseq:NP_001019773.2|refseq:XP_006515829.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:vmI/x564L8rTcob6vkmQLu2+JCQ10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6A065	intact:EBI-645094	intact:EBI-2554140|uniprotkb:Q7TQD9|uniprotkb:Q8BJW2|uniprotkb:Q9D3Z0|ensembl:ENSMUSP00000141793	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ce170_mouse(display_long)|uniprotkb:Kiaa0470(gene name synonym)|uniprotkb:Cep170(gene name)|psi-mi:Cep170(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000057335(gene)|ensembl:ENSMUST00000194727(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q6A065|refseq:XP_006497000.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:gawEp+b6DVpUroRU0JHmHzo7qPg10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6P9K8	intact:EBI-645094	intact:EBI-771526|uniprotkb:Q6ZPU2|uniprotkb:Q8BWU2|uniprotkb:Q8BX99|uniprotkb:Q9CXH0|ensembl:ENSMUSP00000024958	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:cski1_mouse(display_long)|uniprotkb:CASK-interacting protein 1(gene name synonym)|uniprotkb:Caskin1(gene name)|psi-mi:Caskin1(display_short)|uniprotkb:Kiaa1306(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_082213.2|refseq:XP_006524378.1|ensembl:ENSMUSG00000033597(gene)|ensembl:ENSMUST00000024958(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001452(Src homology-3)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR027013|interpro:IPR032117|interpro:IPR032232|interpro:IPR035495|interpro:IPR035497|interpro:IPR035498|interpro:IPR036028|interpro:IPR036770|mint:Q6P9K8	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:zLkBAG7MLTXtMQ0HlY2ox2AumUE10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q60865	intact:EBI-645094	intact:EBI-647767|uniprotkb:Q6IMN3|uniprotkb:Q7TT26|uniprotkb:Q60758|uniprotkb:Q61620|ensembl:ENSMUSP00000028607|ensembl:ENSMUSP00000106777	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:capr1_mouse(display_long)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:Caprin1(gene name)|psi-mi:Caprin1(display_short)|uniprotkb:Gpiap(gene name synonym)|uniprotkb:Gpiap1(gene name synonym)|uniprotkb:Gpip137(gene name synonym)|uniprotkb:M11s1(gene name synonym)|uniprotkb:G5E5(orf name)|uniprotkb:Rng105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001104759.1|refseq:NP_001104760.1|refseq:NP_001104761.1|refseq:NP_001104762.1|refseq:NP_058019.2|ensembl:ENSMUSG00000027184(gene)|ensembl:ENSMUST00000028607(transcript)|ensembl:ENSMUST00000111147(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q60865	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:e+Dcb+82jx+CoLhlGBbdSG62dPU10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8C1B1	intact:EBI-645094	intact:EBI-8839434|uniprotkb:B7ZNI4|uniprotkb:Q80TK8|uniprotkb:Q8C4J5|ensembl:ENSMUSP00000142166	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:camp2_mouse(display_long)|uniprotkb:Camsap2(gene name)|psi-mi:Camsap2(display_short)|uniprotkb:Camsap1l1(gene name synonym)|uniprotkb:Kiaa1078(gene name synonym)|uniprotkb:Calmodulin-regulated spectrin-associated protein 1-like protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001334039.1|refseq:XP_006529897.1|dip:DIP-60092N|ensembl:ENSMUSG00000041570(gene)|ensembl:ENSMUST00000192001(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030507"(spectrin binding)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0033043"(regulation of organelle organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0061564"(axon development)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1990752"(microtubule end)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011033(PRC-barrel-like)|interpro:IPR014797(Protein of unknown function DUF1781)|interpro:IPR022613|interpro:IPR031372|interpro:IPR032940|interpro:IPR036872|interpro:IPR038209	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:x4ewf7BcqG4z/u1twZ3trE3euPk10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q923T9	intact:EBI-645094	intact:EBI-771638|uniprotkb:Q3U3H3|uniprotkb:Q8VED3|ensembl:ENSMUSP00000071720	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kcc2g_mouse(display_long)|uniprotkb:Camk2g(gene name)|psi-mi:Camk2g(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001034227.1|refseq:NP_001034228.1|refseq:NP_848712.2|ensembl:ENSMUSG00000021820(gene)|ensembl:ENSMUST00000071816(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q923T9|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:pbJqcEUQJQRnAwcKozmS72n9s1w10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6PHZ2	intact:EBI-645094	intact:EBI-2308458|uniprotkb:Q3UF87|uniprotkb:Q3UQH9|uniprotkb:Q5DTK4|uniprotkb:Q8CAC5|uniprotkb:Q9CZE2|ensembl:ENSMUSP00000143504	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kcc2d_mouse(display_long)|uniprotkb:Camk2d(gene name)|psi-mi:Camk2d(display_short)|uniprotkb:Kiaa4163(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001020609.1|refseq:NP_076302.1|refseq:NP_001020610.1|refseq:NP_001280592.1|refseq:NP_001280593.1|dip:DIP-47638N|ensembl:ENSMUSG00000053819(gene)|ensembl:ENSMUST00000199300(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031432"(titin binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q6PHZ2|rcsb pdb:6BAB|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:z2mz73Kq9gwpKgo2Todn0IxQpSI10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P28652	intact:EBI-645094	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:P11798	intact:EBI-645094	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8R0S4	intact:EBI-645094	intact:EBI-3647752|uniprotkb:Q3UHK2|uniprotkb:Q8BRN6|uniprotkb:Q8CAJ9|ensembl:ENSMUSP00000077438	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:cacb4_mouse(display_long)|uniprotkb:Cacnb4(gene name)|psi-mi:Cacnb4(display_short)|uniprotkb:Cacnlb4(gene name synonym)|uniprotkb:Calcium channel voltage-dependent subunit beta 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001272356.1|refseq:XP_011237317.1|refseq:NP_001032176.1|refseq:NP_666235.1|refseq:XP_006497704.1|go:"GO:0045202"(synapse)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050877"(nervous system process)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0055001"(muscle cell development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|reactome:R-MMU-112308|go:"GO:0042391"(regulation of membrane potential)|ensembl:ENSMUSG00000017412(gene)|ensembl:ENSMUST00000078324(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0016607"(nuclear speck)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035249"(synaptic transmission, glutamatergic)|refseq:XP_017170652.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:a2B9SMgAy84Ou3mK3Q6aniE71vQ10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8CC27	intact:EBI-645094	intact:EBI-9690121|uniprotkb:A2ASJ8|uniprotkb:Q8C5J5|uniprotkb:Q9CTQ6|ensembl:ENSMUSP00000110371	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:cacb2_mouse(display_long)|uniprotkb:Cacnb2(gene name)|psi-mi:Cacnb2(display_short)|uniprotkb:Cacnlb2(gene name synonym)|uniprotkb:Calcium channel voltage-dependent subunit beta 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001296448.1|refseq:NP_075605.1|refseq:XP_006497383.1|ensembl:ENSMUSG00000057914(gene)|ensembl:ENSMUST00000114723(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007601"(visual perception)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070509"(calcium ion import)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1901843"(positive regulation of high voltage-gated calcium channel activity)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR001452(Src homology-3)|interpro:IPR005444(Voltage-dependent calcium channel, L-type, beta-2 subunit)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035605|interpro:IPR036028|reactome:R-MMU-112308|reactome:R-MMU-422356|reactome:R-MMU-5576892|reactome:R-MMU-5576893	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:v56B+tEzuDuYnl4Fri/+kK+ccSo10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8R3Z5	intact:EBI-645094	intact:EBI-644833|uniprotkb:O88517|uniprotkb:Q7TPF2|uniprotkb:Q8R3Z6|uniprotkb:Q9EPT9|uniprotkb:A2A544	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:cacb1_mouse(display_long)|uniprotkb:Calcium channel voltage-dependent subunit beta 1(gene name synonym)|uniprotkb:Cacnb1(gene name)|psi-mi:Cacnb1(display_short)|uniprotkb:Cacnlb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001152791.1|refseq:NP_112450.1|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001452(Src homology-3)|interpro:IPR005443(Voltage-dependent calcium channel, L-type, beta-1 subunit)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR027417|rcsb pdb:4ZW2|go:"GO:0030315"(T-tubule)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0098793"(presynapse)|reactome:R-MMU-5576892|reactome:R-MMU-5576893|reactome:R-MMU-112308|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|interpro:IPR036028	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:e7XKbBMDfWDxQMlMoCmj8zyECCI10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q5RJI5	intact:EBI-645094	intact:EBI-644361|uniprotkb:A7LH90|uniprotkb:A7LH91|uniprotkb:B7SRN7|uniprotkb:Q699J6|ensembl:ENSMUSP00000039517	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:brsk1_mouse(display_long)|uniprotkb:Sadb(gene name synonym)|uniprotkb:Brain-specific serine/threonine-protein kinase 1(gene name synonym)|uniprotkb:Gm1100(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAD-B(gene name synonym)|uniprotkb:Brsk1(gene name)|psi-mi:Brsk1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001003920.2|refseq:NP_001162044.1|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051298"(centrosome duplication)|go:"GO:0090176"(microtubule cytoskeleton organization involved in establishment of planar polarity)|go:"GO:0099504"(synaptic vesicle cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150034"(distal axon)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5IRI|go:"GO:0050321"(tau-protein kinase activity)|ensembl:ENSMUSG00000035390(gene)|ensembl:ENSMUST00000048248(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0009411"(response to UV)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030182"(neuron differentiation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0005524"(ATP binding)|go:"GO:0048812"(neuron projection morphogenesis)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:hen6KZZ8RSmCcJInuHR6+FsFq2U10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:O08539	intact:EBI-645094	intact:EBI-775152|uniprotkb:Q62434|ensembl:ENSMUSP00000025239	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:bin1_mouse(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:SH3 domain-containing protein 9(gene name synonym)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Sh3p9(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_033798.1|refseq:XP_006526056.1|ensembl:ENSMUSG00000024381(gene)|ensembl:ENSMUST00000025239(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O08539|reactome:R-MMU-8856828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:VdFcKXTcbayNaahmrT13Dju7kLo10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9D219	intact:EBI-645094	intact:EBI-9662251|uniprotkb:B2RQC0|uniprotkb:Q67FX9|uniprotkb:Q8BUJ8|uniprotkb:Q8VE74|ensembl:ENSMUSP00000046152|ensembl:ENSMUSP00000131692	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:bcl9_mouse(display_long)|uniprotkb:Bcl9(gene name)|psi-mi:Bcl9(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_084209.3|refseq:XP_006502351.1|refseq:XP_006502352.1|refseq:XP_006502353.1|ensembl:ENSMUSG00000038256(gene)|ensembl:ENSMUST00000046521(transcript)|ensembl:ENSMUST00000166341(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0014908"(myotube differentiation involved in skeletal muscle regeneration)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015668(B Cell Lymphoma 9)|interpro:IPR024670|reactome:R-MMU-201722	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:QYz6njS6nDJLwQwSs46dnRHr2Mc10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q60875	intact:EBI-645094	intact:EBI-772191|uniprotkb:E9QNW9|uniprotkb:O09115|uniprotkb:Q3TBI4|uniprotkb:Q3TJ16|uniprotkb:Q8CHE1|uniprotkb:Q923E0|uniprotkb:Q9ESG7|ensembl:ENSMUSP00000029694	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:arhg2_mouse(display_long)|uniprotkb:Kiaa0651(gene name synonym)|uniprotkb:Lbcl1(gene name synonym)|uniprotkb:Lfc(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Lymphoid blast crisis-like 1(gene name synonym)|uniprotkb:LBC'S first cousin(gene name synonym)|uniprotkb:Oncogene LFC(gene name synonym)|uniprotkb:Rhobin(gene name synonym)|uniprotkb:Arhgef2(gene name)|psi-mi:Arhgef2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_001185840.1|refseq:NP_001185841.1|refseq:NP_001185842.1|refseq:NP_032513.3|refseq:XP_006501130.1|ensembl:ENSMUSG00000028059(gene)|ensembl:ENSMUST00000029694(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002102"(podosome)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071802"(negative regulation of podosome assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037806|interpro:IPR041020|mint:Q60875|rcsb pdb:5WI4|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:Le4PMm1AT/ManVpetNT2wBsUlok10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6P9R4	intact:EBI-645094	intact:EBI-6271853|uniprotkb:E9QK59|uniprotkb:Q6A055|uniprotkb:Q8BYA4|uniprotkb:Q8K227	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:arhgi_mouse(display_long)|uniprotkb:Arhgef18(gene name)|psi-mi:Arhgef18(display_short)|uniprotkb:Kiaa0521(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0045177"(apical part of cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0150105"(protein localization to cell-cell junction)|reactome:R-MMU-8980692|reactome:R-MMU-9013149|interpro:IPR037744|rcsb pdb:6BCB|refseq:NP_598723.3|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035899|reactome:R-MMU-193648|reactome:R-MMU-2173791|interpro:IPR041020|reactome:R-MMU-416482	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:IUJreADJCc2If1ymHyN/QYQFcHY10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8C4V1	intact:EBI-645094	intact:EBI-16728015|uniprotkb:Q8CA50|uniprotkb:Q8QZZ0	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:rhg24_mouse(display_long)|uniprotkb:Rho-type GTPase-activating protein 24(gene name synonym)|uniprotkb:Arhgap24(gene name)|psi-mi:Arhgap24(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0001525"(angiogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0030154"(cell differentiation)|go:"GO:0035021"(negative regulation of Rac protein signal transduction)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0042995"(cell projection)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900028"(negative regulation of ruffle assembly)|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|refseq:NP_001273397.1|refseq:NP_083546.2|refseq:NP_666273.1|refseq:XP_006534954.1|refseq:XP_011247736.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000198(RhoGAP)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:6Yp2PbJuJf0v1PfsqWRhZRslJ4E10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q6DFV3	intact:EBI-645094	intact:EBI-16727982|uniprotkb:A2AL67|uniprotkb:Q80TD7|uniprotkb:Q80XS1	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:rhg21_mouse(display_long)|uniprotkb:Rho GTPase-activating protein 10(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 21(gene name synonym)|uniprotkb:Arhgap21(gene name)|psi-mi:Arhgap21(display_short)|uniprotkb:Arhgap10(gene name synonym)|uniprotkb:Kiaa1424(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	interpro:IPR041489|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0051645"(Golgi localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0072384"(organelle transport along microtubule)|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-9696264|refseq:NP_001074833.3|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000198(RhoGAP)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:cfHEMUK7sE6c++73unq5fpTL6Y810090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q99NH0	intact:EBI-645094	intact:EBI-647840|uniprotkb:Q3TV99|uniprotkb:Q5F4T7|uniprotkb:Q6PG69|uniprotkb:Q6ZQ66|uniprotkb:Q8CHT4|ensembl:ENSMUSP00000014421	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:anr17_mouse(display_long)|uniprotkb:Foe(gene name synonym)|uniprotkb:Kiaa0697(gene name synonym)|uniprotkb:Gene trap ankyrin repeat protein(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein FOE(gene name synonym)|uniprotkb:Ankrd17(gene name)|psi-mi:Ankrd17(display_short)|uniprotkb:Gtar(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_112148.2|ensembl:ENSMUSG00000055204(gene)|ensembl:ENSMUST00000014421(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007492"(endoderm development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|mint:Q99NH0	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:c/59Xwrg6uFRRx34dzmzkER9Lik10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q8CJG1	intact:EBI-645094	intact:EBI-2291996|uniprotkb:A1L365|ensembl:ENSMUSP00000095498|ensembl:ENSMUSP00000159361	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:ago1_mouse(display_long)|uniprotkb:Ago1(gene name)|psi-mi:Ago1(display_short)|uniprotkb:Argonaute RISC catalytic component 1(gene name synonym)|uniprotkb:Eif2c1(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 1(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_700452.2|refseq:NP_001304102.1|ensembl:ENSMUSG00000041530(gene)|ensembl:ENSMUST00000097888(transcript)|ensembl:ENSMUST00000239428(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070578"(RISC-loading complex)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG1|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:l/WmIsnfJjifEOoxOyG9zDo2ljQ10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35922	uniprotkb:Q9ESC8	intact:EBI-645094	intact:EBI-6261083|ensembl:ENSMUSP00000051479|uniprotkb:B2RST9|uniprotkb:Q8C6W3|uniprotkb:Q8C6K4|uniprotkb:Q8CCH3	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:aff4_mouse(display_long)|uniprotkb:Alf4(gene name synonym)|uniprotkb:Aff4(gene name)|psi-mi:Aff4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16728828|imex:IM-26285-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	ensembl:ENSMUSG00000049470(gene)|ensembl:ENSMUST00000060945(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|mint:Q9ESC8|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-75955|go:"GO:0032783"(super elongation complex)|refseq:XP_011247633.1|refseq:NP_291043.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:/pYgaSgjBhwmauoRLYO1WIskmzU10090	rigid:uLINQ6DmlL1FTudx4EjwqLuHGkY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q61937	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-626362|ensembl:ENSMUSP00000075067	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:npm_mouse(display_long)|uniprotkb:Nucleolar phosphoprotein B23(gene name synonym)|uniprotkb:Numatrin(gene name synonym)|uniprotkb:Nucleolar protein NO38(gene name synonym)|uniprotkb:Npm1(gene name)|psi-mi:Npm1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060699"(regulation of endoribonuclease activity)|go:"GO:0060735"(regulation of eIF2 alpha phosphorylation by dsRNA)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097421"(liver regeneration)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902629"(regulation of mRNA stability involved in cellular response to UV)|go:"GO:1902751"(positive regulation of cell cycle G2/M phase transition)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004301(Nucleoplasmin)|interpro:IPR024057|interpro:IPR032569|interpro:IPR036824|mint:Q61937|rcsb pdb:4N8M|reactome:R-MMU-3899300|reactome:R-MMU-606279|reactome:R-MMU-6804115|reactome:R-MMU-8869496|ensembl:ENSMUSG00000057113(gene)|ensembl:ENSMUST00000075641(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0000448"("cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001652"(granular component)|go:"GO:0002039"(p53 binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009303"(rRNA transcription)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0019843"(rRNA binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030957"(Tat protein binding)|refseq:NP_032748.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:i/cYJMIvj0nTZoQNh4thiojopbA10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q7TPH6	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8CIN4	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-1559317|ensembl:ENSMUSP00000023467	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:pak2_mouse(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:Pak2(gene name)|psi-mi:Pak2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_796300.1|refseq:XP_006522135.1|dip:DIP-39167N|ensembl:ENSMUSG00000022781(gene)|ensembl:ENSMUST00000023467(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q8CIN4|reactome:R-MMU-202433|reactome:R-MMU-2871796|reactome:R-MMU-389359|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-4420097|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:5J6RxkZotYPD92E0NgUv+ADI+HA10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8CJG0	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q6PDG5	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-3870565|uniprotkb:Q6P6P3|ensembl:ENSMUSP00000100868	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:smrc2_mouse(display_long)|uniprotkb:Smarcc2(gene name)|psi-mi:Smarcc2(display_short)|uniprotkb:Baf170(gene name synonym)|uniprotkb:BRG1-associated factor 170(gene name synonym)|uniprotkb:SWI/SNF complex 170 kDa subunit(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001107568.1|refseq:NP_001107569.1|refseq:NP_937803.1|dip:DIP-48884N|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0042393"(histone binding)|ensembl:ENSMUSG00000025369(gene)|go:"GO:0043044"|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000953(Chromo domain)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR007526(SWIRM)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR032448|interpro:IPR032450|interpro:IPR032451|interpro:IPR036388|interpro:IPR036420|interpro:IPR038044|mint:Q6PDG5|reactome:R-MMU-3214858|reactome:R-MMU-8939243|ensembl:ENSMUST00000105235(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:v8cjo/1nUFl5vd96cKMcY8LA8M010090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8CGF6	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8316986|intact:MINT-4140349|uniprotkb:Q80TP4|uniprotkb:A2AGC7|ensembl:ENSMUSP00000057482	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:wdr47_mouse(display_long)|uniprotkb:Wdr47(gene name)|psi-mi:Wdr47(display_short)|uniprotkb:Kiaa0893(gene name synonym)|uniprotkb:Neuronal enriched MAP interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_852065.2|refseq:XP_017175308.1|dip:DIP-58945N|ensembl:ENSMUSG00000040389(gene)|ensembl:ENSMUST00000051145(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR036322|interpro:IPR040067|mint:Q8CGF6	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:t4myqVx9Xs1MBbib6vp11Wylu9Y10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q91VX2	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8393848|uniprotkb:Q812D6|intact:MINT-4121131|uniprotkb:Q99K40|ensembl:ENSMUSP00000030143	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ubap2_mouse(display_long)|uniprotkb:Ubap2(gene name)|psi-mi:Ubap2(display_short)|uniprotkb:Lig1(gene name synonym)|uniprotkb:Protein lingerer homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_081148.1|refseq:XP_006538287.1|ensembl:ENSMUSG00000028433(gene)|ensembl:ENSMUST00000030143(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q91VX2	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:1DmCkNUYKiOhbvmQCOs8L2+/vf010090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9Z1Z2	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8320895|uniprotkb:Q8BP89|intact:MINT-1870065|uniprotkb:Q8C6F6|ensembl:ENSMUSP00000068267	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:strap_mouse(display_long)|uniprotkb:Strap(gene name)|psi-mi:Strap(display_short)|uniprotkb:Unrip(gene name synonym)|uniprotkb:UNR-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_035629.2|ensembl:ENSMUSG00000030224(gene)|ensembl:ENSMUST00000064910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0022618"(ribonucleoprotein complex assembly)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0048856"(anatomical structure development)|go:"GO:1990447"(U2 snRNP binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|mint:Q9Z1Z2|reactome:R-MMU-2173788	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	function:The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:9MyPF8yI+ysf0lmDMYE+FNicL9g10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8K1N4	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8440204|uniprotkb:Q8C810|uniprotkb:Q3UX77|uniprotkb:Q8R1P6|intact:MINT-4117082|ensembl:ENSMUSP00000070549	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:spas2_mouse(display_long)|uniprotkb:Spats2(gene name)|psi-mi:Spats2(display_short)|uniprotkb:Scr59(gene name synonym)|uniprotkb:Serine-rich spermatocytes and round spermatid 59 kDa protein(gene name synonym)|uniprotkb:p59scr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:XP_011244039.1|refseq:NP_631879.1|ensembl:ENSMUSG00000051934(gene)|ensembl:ENSMUST00000063517(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR009060(UBA-like)|interpro:IPR009816(Protein of unknown function DUF1387)|mint:Q8K1N4	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:pHYbbujEidsiqFiPzHScEMINoTI10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P59110	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8458593|intact:MINT-4112452|uniprotkb:Q8BZF1|uniprotkb:Q8BTV5|ensembl:ENSMUSP00000046598	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:senp1_mouse(display_long)|uniprotkb:Senp1(gene name)|psi-mi:Senp1(display_short)|uniprotkb:Supr2(gene name synonym)|uniprotkb:Sentrin/SUMO-specific protease SENP1(gene name synonym)|uniprotkb:SUMO-1 protease 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_659100.1|ensembl:ENSMUSG00000033075(gene)|ensembl:ENSMUST00000044189(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0016926"(protein desumoylation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR003653(Peptidase C48, SUMO/Sentrin/Ubl1)|interpro:IPR038765|mint:P59110|reactome:R-MMU-3065679|reactome:R-MMU-9035034	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:mint|function:"Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:1fM83onHzXXa4h3rsw6fIcCu6Hc10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8K224	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8387859|intact:MINT-4117163|intact:UNK-5489633|uniprotkb:Q3UE04|uniprotkb:Q8BW78|uniprotkb:Q6ZPJ7|uniprotkb:Q80VD3|ensembl:ENSMUSP00000028608	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:nat10_mouse(display_long)|uniprotkb:18S rRNA cytosine acetyltransferase(gene name synonym)|uniprotkb:N-acetyltransferase 10(gene name synonym)|uniprotkb:Nat10(gene name)|psi-mi:Nat10(display_short)|uniprotkb:Kiaa1709(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_694766.1|ensembl:ENSMUSG00000027185(gene)|ensembl:ENSMUST00000028608(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0030496"(midbody)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051391"(tRNA acetylation)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0106162"(mRNA N-acetyltransferase activity)|go:"GO:1904812"(rRNA acetylation involved in maturation of SSU-rRNA)|go:"GO:1990883"(rRNA cytidine N-acetyltransferase activity)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR007807(Protein of unknown function DUF699, ATPase putative)|interpro:IPR013562(Region of unknown function DUF1726)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR027992|interpro:IPR032672|interpro:IPR033688|mint:Q8K224	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:aQypsoKWU81CbIbLIxupBf+a6J810090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8BI84	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8381636|intact:MINT-4110703|uniprotkb:Q8BJE9|uniprotkb:Q8BL31|uniprotkb:Q571D7|uniprotkb:Q8C5B9|uniprotkb:A0JLX8|uniprotkb:Q3UFI9	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:tgo1_mouse(display_long)|uniprotkb:Melanoma inhibitory activity protein 3(gene name synonym)|uniprotkb:Tango(gene name synonym)|uniprotkb:Mia3(gene name)|psi-mi:Mia3(display_short)|uniprotkb:Kiaa0268(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_796363.2|interpro:IPR036028|mint:Q8BI84|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0009306"(protein secretion)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:2000402"(negative regulation of lymphocyte migration)|reactome:R-MMU-381426|reactome:R-MMU-5694530|reactome:R-MMU-8957275|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|interpro:IPR001452(Src homology-3)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:1kvtHvTGPvdykzgLlUixuTnF/dE10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8C9B9	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8340028|uniprotkb:A2AJ47|uniprotkb:Q3ZTP5|uniprotkb:A2AJ48|uniprotkb:Q4V9W1|uniprotkb:Q8BMD0|uniprotkb:Q8BRG2|uniprotkb:Q8CHR5|uniprotkb:B2RS46|uniprotkb:Q6ZQD7|uniprotkb:Q3ZTP6|uniprotkb:Q05C59|uniprotkb:Q80V34|uniprotkb:Q9WV00|intact:MINT-4111472|ensembl:ENSMUSP00000084794	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:dido1_mouse(display_long)|uniprotkb:Dido1(gene name)|psi-mi:Dido1(display_short)|uniprotkb:Datf1(gene name synonym)|uniprotkb:Dio1(gene name synonym)|uniprotkb:Death-associated transcription factor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_808520.2|refseq:NP_780760.2|refseq:NP_035935.2|refseq:XP_006500671.1|refseq:XP_006500672.1|refseq:XP_006500673.1|refseq:XP_006500674.1|refseq:XP_006500675.1|refseq:XP_006500678.1|refseq:XP_006500679.1|refseq:NP_001278361.1|refseq:NP_001278362.1|ensembl:ENSMUSG00000038914(gene)|ensembl:ENSMUST00000087517(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003618(Transcription elongation factor S-II, central region)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR012921(Spen paralogue and orthologue C-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR033082|interpro:IPR036575|mint:Q8C9B9|rcsb pdb:1WEM	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:mint|function:Putative transcription factor, weakly pro-apoptotic when overexpressed	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:dMthBBfD+e96GyEkwCBsH7lsJ/810090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:O35451	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8361741|intact:MINT-4088730	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:atf6b_mouse(display_long)|uniprotkb:Crebl1(gene name synonym)|uniprotkb:Activating transcription factor 6 beta(gene name synonym)|uniprotkb:cAMP-responsive element-binding protein-like 1(gene name synonym)|uniprotkb:cAMP response element-binding protein-related protein(gene name synonym)|uniprotkb:Atf6b(gene name)|psi-mi:Atf6b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	dip:DIP-61156N|mint:O35451|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903892"(negative regulation of ATF6-mediated unfolded protein response)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029809	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:mint|function:"Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:PXEAJqLw3G4oeh5loSXXMzgjfTk10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q91W18	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8329718|uniprotkb:Q8C1A4|uniprotkb:Q8BZW6|intact:UNK-5479555|intact:MINT-4137349|uniprotkb:E9Q2Q4|intact:UNK-5512156|uniprotkb:Q6NZG7|ensembl:ENSMUSP00000129019	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:tdrd3_mouse(display_long)|uniprotkb:Tdrd3(gene name)|psi-mi:Tdrd3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001240684.1|refseq:NP_766193.3|ensembl:ENSMUSG00000022019(gene)|ensembl:ENSMUST00000168275(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006397"(mRNA processing)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035145"(exon-exon junction complex)|interpro:IPR002999(Tudor)|interpro:IPR009060(UBA-like)|interpro:IPR010304(Survival motor neuron)|interpro:IPR013894(Region of unknown function DUF1767)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR033472|interpro:IPR041915|interpro:IPR042470|mint:Q91W18|rcsb pdb:2D9T	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:OJkc6E7+tTHuVr5BSCn8MtiApZk10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q3UYC0	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8321593|uniprotkb:Q571C9|uniprotkb:Q8BYE6|intact:MINT-5174682|uniprotkb:Q3V3H5|uniprotkb:Q3V3Y7|uniprotkb:Q7TMU7|uniprotkb:Q3UD05|ensembl:ENSMUSP00000066561	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ppm1h_mouse(display_long)|uniprotkb:Ppm1h(gene name)|psi-mi:Ppm1h(display_short)|uniprotkb:Kiaa1157(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001103688.1|refseq:NP_795893.2|ensembl:ENSMUSG00000034613(gene)|ensembl:ENSMUST00000067918(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q3UYC0	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:Tk66NSF9CbBNxhIfkqpPH3pUziU10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q00PI9	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8586171|ensembl:ENSMUSP00000094515|uniprotkb:F8VPM4|intact:UNK-5385063	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:hnrl2_mouse(display_long)|uniprotkb:Manp(gene name synonym)|uniprotkb:Hnrpul2(gene name synonym)|uniprotkb:MLF1-associated nuclear protein(gene name synonym)|uniprotkb:Hnrnpul2(gene name)|psi-mi:Hnrnpul2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000071659(gene)|ensembl:ENSMUST00000096753(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|refseq:NP_001074665.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:oPTke2/M1XC8ou8Lcc4UY4Qz8sw10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9WVR4	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8572772|uniprotkb:Q9WVR5|intact:UNK-5560063	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:fxr2_mouse(display_long)|uniprotkb:Fxr2(gene name)|psi-mi:Fxr2(display_short)|uniprotkb:Fxr2h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	interpro:IPR032172|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0045182"(translation regulator activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR022034|interpro:IPR008395(Agenet)|interpro:IPR004088(K Homology, type 1)|interpro:IPR040472|interpro:IPR040148|interpro:IPR036612|interpro:IPR041560	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	function:RNA-binding protein|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:q56uykuU0MnJ8r9/CdCuFG+ML0M10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q6A0A9	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8327719|intact:MINT-1858841|uniprotkb:Q91Z16|uniprotkb:B3DFJ0|uniprotkb:A0PJK6|ensembl:ENSMUSP00000053877	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:f120a_mouse(display_long)|uniprotkb:Kiaa0183(gene name synonym)|uniprotkb:Ossa(gene name synonym)|uniprotkb:Oxidative stress-associated Src activator(gene name synonym)|uniprotkb:Protein FAM120A(gene name synonym)|uniprotkb:FAM120A(gene name)|psi-mi:FAM120A(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001028440.2|ensembl:ENSMUSG00000038014(gene)|ensembl:ENSMUST00000060805(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR026784|interpro:IPR029060|mint:Q6A0A9	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:"fragmentation type: fragment"|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:tZj0TOhfuvvF4GaEPHI7jWpKyl810090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q61701	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8339146|uniprotkb:A2A9R6|uniprotkb:A2A9R8|uniprotkb:A2A9S0|uniprotkb:A2A9S1|uniprotkb:A2A9S2|uniprotkb:A2A9S3|uniprotkb:Q6PHZ3|uniprotkb:Q8BVA9|intact:MINT-4094262|uniprotkb:O55010|uniprotkb:A2A9R7|ensembl:ENSMUSP00000102207	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:elav4_mouse(display_long)|uniprotkb:Elavl4(gene name)|psi-mi:Elavl4(display_short)|uniprotkb:Hud(gene name synonym)|uniprotkb:Paraneoplastic encephalomyelitis antigen HuD(gene name synonym)|uniprotkb:Hu-antigen D(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001033787.1|refseq:NP_034618.2|refseq:NP_001334107.1|refseq:XP_006502862.1|ensembl:ENSMUSG00000028546(gene)|ensembl:ENSMUST00000106597(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008306"(associative learning)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031099"(regeneration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0097158"(pre-mRNA intronic pyrimidine-rich binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1905870"(positive regulation of 3'-UTR-mediated mRNA stabilization)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034918|interpro:IPR035979|mint:Q61701	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	function:May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:HXthuBphfQOW5EWQAG1smb8ljZY10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q60899	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8329853|intact:MINT-4094224|ensembl:ENSMUSP00000008633	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:elav2_mouse(display_long)|uniprotkb:Elavl2(gene name)|psi-mi:Elavl2(display_short)|uniprotkb:Hub(gene name synonym)|uniprotkb:Hu-antigen B(gene name synonym)|uniprotkb:ELAV-like neuronal protein 1(gene name synonym)|uniprotkb:Nervous system-specific RNA-binding protein Mel-N1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_034616.1|refseq:XP_006502852.1|refseq:XP_006502853.1|refseq:XP_006502854.1|ensembl:ENSMUSG00000008489(gene)|ensembl:ENSMUST00000008633(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0045202"(synapse)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034914|interpro:IPR034999|interpro:IPR035979|mint:Q60899|reactome:R-MMU-72163	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:mint|function:Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:dgDCiu1mN8mz6K95+ihBGQY8K8k10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:E9Q444	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16729663|ensembl:ENSMUSP00000109363	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:e9q444_mouse(display_long)|uniprotkb:Zbtb21(gene name)|psi-mi:Zbtb21(display_short)|uniprotkb:Zfp295(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000046962(gene)|ensembl:ENSMUST00000113734(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0031208"(POZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041011|refseq:NP_780637.2|refseq:XP_006522920.1|refseq:XP_006522921.1|refseq:XP_017172342.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:3bTJGYxlTGQuSc70tviNjTSp52E10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q6IQX8	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-3044006|ensembl:ENSMUSP00000068184|ensembl:ENSMUSP00000126854|ensembl:ENSMUSP00000154709|uniprotkb:Q921W9|uniprotkb:Q924S6|uniprotkb:Q9CVF3|intact:EBI-3508329	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:zn219_mouse(display_long)|uniprotkb:Znf219(gene name)|psi-mi:Znf219(display_short)|uniprotkb:Zfp219(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000049295(gene)|ensembl:ENSMUST00000067549(transcript)|ensembl:ENSMUST00000166169(transcript)|ensembl:ENSMUST00000226522(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0060174"(limb bud formation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q6IQX8|refseq:XP_011243478.1|refseq:XP_011243479.1|refseq:XP_017171669.1|refseq:NP_081524.2|refseq:NP_001240623.1|refseq:NP_001240624.1|refseq:XP_006519561.1|refseq:XP_006519562.1|refseq:XP_006519564.1|refseq:XP_006519565.1|refseq:XP_006519566.1|refseq:XP_006519567.1|refseq:XP_006519568.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:Q6ebFbVDwgd46TS1dBOEk3kNYO410090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P20152	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-299269|ensembl:ENSMUSP00000028062|uniprotkb:O08704|uniprotkb:Q8CCH1	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:vime_mouse(display_long)|uniprotkb:Vim(gene name)|psi-mi:Vim(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000026728(gene)|ensembl:ENSMUST00000028062(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1900147"(regulation of Schwann cell migration)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031252"(cell leading edge)|interpro:IPR027699|interpro:IPR039008|mint:P20152|reactome:R-MMU-264870|reactome:R-MMU-390522|reactome:R-MMU-9013422|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|reactome:R-MMU-9646399|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044297"(cell body)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045103"(intermediate filament-based process)|refseq:NP_035831.2|dip:DIP-188N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid://GDvGAXOR4hUXNtVpnZefex5v410090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P70398	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2214043|uniprotkb:E9QLY0|uniprotkb:Q62497	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:usp9x_mouse(display_long)|uniprotkb:Ubiquitin thioesterase FAF-X(gene name synonym)|uniprotkb:Usp9x(gene name)|psi-mi:Usp9x(display_short)|uniprotkb:Fafl(gene name synonym)|uniprotkb:Fam(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-X(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-X(gene name synonym)|uniprotkb:Fat facets protein-related, X-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, X chromosome(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase FAM(gene name synonym)|uniprotkb:Fat facets homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	interpro:IPR016024(Armadillo-type fold)|interpro:IPR028889|refseq:NP_033507.2|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:P70398|interpro:IPR038765|interpro:IPR021905|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021698"(cerebellar cortex structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0030426"(growth cone)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045177"(apical part of cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|reactome:R-MMU-2173795|reactome:R-MMU-5689880|reactome:R-MMU-8866652|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-9033241	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:QXx5gkd+PxoNgIj2b2dLjpCuNr410090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q80X50	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-11664310|uniprotkb:Q8BIT6|uniprotkb:Q8BIW4|uniprotkb:Q8BJ01|uniprotkb:Q8CIG7|uniprotkb:Q8K102|uniprotkb:Q9CRT6|ensembl:ENSMUSP00000143459	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ubp2l_mouse(display_long)|uniprotkb:Ubap2l(gene name)|psi-mi:Ubap2l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001159455.1|refseq:NP_001159456.1|refseq:NP_001159457.1|refseq:NP_001159458.1|refseq:NP_082751.1|refseq:XP_006502235.1|ensembl:ENSMUSG00000042520(gene)|ensembl:ENSMUST00000196843(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q80X50|rcsb pdb:1WJ7	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:ucHEy1MXF7PTEdwLChr6zAOqtcM10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:O88196	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-310028|uniprotkb:Q05D15|uniprotkb:Q3TMM9|uniprotkb:Q3TPC8|uniprotkb:Q3TPV5|uniprotkb:Q3TQL0|uniprotkb:Q3TSK0|uniprotkb:Q3UFH5|uniprotkb:Q5DTM5|uniprotkb:Q6PG61|uniprotkb:Q8BPM4|uniprotkb:Q8C2N6	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ttc3_mouse(display_long)|uniprotkb:Ttc3(gene name)|psi-mi:Ttc3(display_short)|uniprotkb:Kiaa4119(gene name synonym)|uniprotkb:TPR repeat protein D(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TTC3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010771"(negative regulation of cell morphogenesis involved in differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR011029(DEATH-like)|interpro:IPR043866	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:c0v6smzObgNddoQsFT81OB1Fe6Q10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q62318	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-346909|uniprotkb:P70391|uniprotkb:Q8C283|uniprotkb:Q99PN4|ensembl:ENSMUSP00000005705	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:tif1b_mouse(display_long)|uniprotkb:Trim28(gene name)|psi-mi:Trim28(display_short)|uniprotkb:Krip1(gene name synonym)|uniprotkb:Tif1b(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:KRAB-A-interacting protein(gene name synonym)|uniprotkb:KRIP-1(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:Kap1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_035718.2|dip:DIP-31477N|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q62318|rcsb pdb:6O5K|reactome:R-MMU-212436|ensembl:ENSMUSG00000005566(gene)|ensembl:ENSMUST00000005705(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:DvGJxQNohVWs++QEAyrqe4ngcz810090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9Z321	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16728364|ensembl:ENSMUSP00000023465|ensembl:ENSMUSP00000156132	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:top3b_mouse(display_long)|uniprotkb:DNA topoisomerase III beta-1(gene name synonym)|uniprotkb:Top3b(gene name)|psi-mi:Top3b(display_short)|uniprotkb:Top3b1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000022779(gene)|ensembl:ENSMUST00000023465(transcript)|ensembl:ENSMUST00000232581(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007059"(chromosome segregation)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|mint:Q9Z321|refseq:NP_001313505.1|refseq:NP_035754.1|refseq:XP_006522054.1|refseq:XP_006522055.1|refseq:XP_006522057.1|refseq:XP_006522058.1|refseq:XP_017172426.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:9m6mpZ7aIV3fx3bU6opc3sFN3SA10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q569Z6	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2536252|ensembl:ENSMUSP00000079722	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:tr150_mouse(display_long)|uniprotkb:Thrap3(gene name)|psi-mi:Thrap3(display_short)|uniprotkb:Trap150(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 150 kDa component(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000043962(gene)|ensembl:ENSMUST00000080919(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR026667|interpro:IPR029199|go:"GO:0008380"(RNA splicing)|refseq:XP_011238805.1|refseq:NP_666265.3|refseq:XP_006503104.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:Cb0vHuEX3Ew27z2gvfC/36tdeYE10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:O08784	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-6261057|ensembl:ENSMUSP00000135476|uniprotkb:O08857	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:tcof_mouse(display_long)|uniprotkb:Treacher Collins syndrome protein homolog(gene name synonym)|uniprotkb:Tcof1(gene name)|psi-mi:Tcof1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000024613(gene)|ensembl:ENSMUST00000176630(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042790"(nucleolar large rRNA transcription by RNA polymerase I)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003993(Treacher Collins syndrome, treacle)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR017859|mint:O08784|refseq:NP_035682.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:oyn9kai+jDLD39W9rDIKMHj3Qgw10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9WUN2	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-764193|uniprotkb:Q9CT90|uniprotkb:Q9DC03|ensembl:ENSMUSP00000020316	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:tbk1_mouse(display_long)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:Tbk1(gene name)|psi-mi:Tbk1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_062760.3|dip:DIP-29880N|interpro:IPR041087|interpro:IPR041309|mint:Q9WUN2|rcsb pdb:4JL9|rcsb pdb:4JLC|rcsb pdb:6O8C|reactome:R-MMU-168928|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-9008059|reactome:R-MMU-936440|reactome:R-MMU-936964|ensembl:ENSMUSG00000020115(gene)|ensembl:ENSMUST00000020316(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:yuQ8W5zOu+0zBDNIy3E3Ox8375410090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:O55106	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2479958|uniprotkb:B2RWV9|uniprotkb:Q5BKR9|ensembl:ENSMUSP00000120830	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:strn_mouse(display_long)|uniprotkb:Strn(gene name)|psi-mi:Strn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000024077(gene)|ensembl:ENSMUST00000145910(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016358"(dendrite development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030425"(dendrite)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR013258(Striatin, N-terminal)|go:"GO:0014069"(postsynaptic density)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:O55106|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9009391|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_035630.2	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:tUJDyyIWZKuEBcyJKUIbk2dR4JE10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8BZ60	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-539385|uniprotkb:A2RTJ7|ensembl:ENSMUSP00000053908	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ston2_mouse(display_long)|uniprotkb:Stoned B(gene name synonym)|uniprotkb:Ston2(gene name)|psi-mi:Ston2(display_short)|uniprotkb:Stnb(gene name synonym)|uniprotkb:Stn2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:XP_011242284.1|refseq:NP_780576.1|refseq:XP_006515436.1|refseq:XP_006515437.1|ensembl:ENSMUSG00000020961(gene)|ensembl:ENSMUST00000052969(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0098793"(presynapse)|interpro:IPR012320(Stonin homology)|interpro:IPR017110(Stonin)|interpro:IPR022699|interpro:IPR028565|interpro:IPR031228|interpro:IPR036168|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:WSC63ux7x73j2raATjnmIv86lSM10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q6PDM2	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2550360|ensembl:ENSMUSP00000120595|uniprotkb:B2KGJ5|uniprotkb:Q3UCH2|uniprotkb:Q5SXC5|uniprotkb:Q8BJV3|uniprotkb:Q8C1H9	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:srsf1_mouse(display_long)|uniprotkb:Sfrs1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)|uniprotkb:Srsf1(gene name)|psi-mi:Srsf1(display_short)|uniprotkb:ASF/SF2(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SRp30a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000018379(gene)|ensembl:ENSMUST00000139129(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0050733"(RS domain binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q6PDM2|rcsb pdb:1X4C|go:"GO:0005654"(nucleoplasm)|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|reactome:R-MMU-72165|refseq:NP_001071635.1|refseq:NP_775550.2|dip:DIP-48723N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:O54781	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-593325|uniprotkb:Q8VCD9	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:srpk2_mouse(display_long)|uniprotkb:Serine/arginine-rich protein-specific kinase 2(gene name synonym)|uniprotkb:SFRS protein kinase 2(gene name synonym)|uniprotkb:Srpk2(gene name)|psi-mi:Srpk2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	mint:O54781|refseq:NP_033300.2|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|refseq:XP_017176258.1|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000785"(chromatin)|go:"GO:0001525"(angiogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:w16BWU5PrwNUPMC4Yw83eDldbrA10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q5DU57	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16726449|uniprotkb:Q3TZ09	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:spt13_mouse(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:Spata13(gene name)|psi-mi:Spata13(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046847"(filopodium assembly)|reactome:R-MMU-9013149|reactome:R-MMU-9013148|refseq:NP_001028444.1|refseq:NP_001297523.1|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR036028|interpro:IPR001452(Src homology-3)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:bv1eL5RAkdw2LYvmRRRWxO6uZ5810090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:E1U8D0	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16728709	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:soga1_mouse(display_long)|uniprotkb:SOGA family member 1(gene name synonym)|uniprotkb:Suppressor of glucose by autophagy(gene name synonym)|uniprotkb:Suppressor of glucose, autophagy-associated protein 1(gene name synonym)|uniprotkb:Soga1(gene name)|psi-mi:Soga1(display_short)|uniprotkb:Soga(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0005615"(extracellular space)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0045721"(negative regulation of gluconeogenesis)|interpro:IPR027882|interpro:IPR027881	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:Kk7DCpjGgjPDQ/NrzlscsMuBDGg10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9CSN1	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2551848	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:snw1_mouse(display_long)|uniprotkb:Skiip(gene name synonym)|uniprotkb:Nuclear protein SkiP(gene name synonym)|uniprotkb:Ski-interacting protein(gene name synonym)|uniprotkb:Snw1(gene name)|psi-mi:Snw1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0070564"(positive regulation of vitamin D receptor signaling pathway)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071300"(cellular response to retinoic acid)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|reactome:R-MMU-2122947|reactome:R-MMU-2173796|reactome:R-MMU-350054|reactome:R-MMU-72163|reactome:R-MMU-8941856|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048385"(regulation of retinoic acid receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|refseq:NP_079783.2|dip:DIP-42051N|mint:Q9CSN1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:WKh+5sKG7RoxwHBF/GzueCqA4j410090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q3TKT4	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-1210244|uniprotkb:Q6AXG8|uniprotkb:Q3TUD7|ensembl:ENSMUSP00000133922	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:smca4_mouse(display_long)|uniprotkb:Smarca4(gene name)|psi-mi:Smarca4(display_short)|uniprotkb:Baf190a(gene name synonym)|uniprotkb:Brg1(gene name synonym)|uniprotkb:Snf2b(gene name synonym)|uniprotkb:Snf2l4(gene name synonym)|uniprotkb:ATP-dependent helicase SMARCA4(gene name synonym)|uniprotkb:BRG1-associated factor 190A(gene name synonym)|uniprotkb:Protein brahma homolog 1(gene name synonym)|uniprotkb:SNF2-beta(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001167549.1|refseq:NP_001167550.1|refseq:NP_035547.2|refseq:XP_006510180.2|refseq:XP_006510182.2|refseq:XP_006510183.2|dip:DIP-40650N|dip:DIP-59249N|ensembl:ENSMUSG00000032187(gene)|ensembl:ENSMUST00000174008(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001188"(RNA polymerase I preinitiation complex assembly)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0001889"(liver development)|go:"GO:0002039"(p53 binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007399"(nervous system development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0007507"(heart development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010424"(DNA methylation on cytosine within a CG sequence)|go:"GO:0010467"(gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030900"(forebrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030957"(Tat protein binding)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035887"(aortic smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0043044"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048562"(embryonic organ morphogenesis)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902661"(positive regulation of glucose mediated signaling pathway)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030100|interpro:IPR036427|interpro:IPR038718|mint:Q3TKT4|reactome:R-MMU-1266695|reactome:R-MMU-201722|reactome:R-MMU-3214858|reactome:R-MMU-3247509|reactome:R-MMU-8939243|interpro:IPR037259	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:uLQrygmWWugY//OpA2aX4t2VgmM10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:G3X972	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-11079353|ensembl:ENSMUSP00000045955	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:g3x972_mouse(display_long)|uniprotkb:Sec24c(gene name)|psi-mi:Sec24c(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_766184.2|ensembl:ENSMUSG00000039367(gene)|ensembl:ENSMUST00000048657(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR007123(Gelsolin region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR041742|reactome:R-MMU-204005|reactome:R-MMU-2132295|reactome:R-MMU-5694530|reactome:R-MMU-983170	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:khjAPBQKBRzNnYP47XMkNTMX7cE10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:E9QAT4	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-647676|uniprotkb:A2AIX1|uniprotkb:Q80U43|uniprotkb:Q811L5|intact:EBI-8820930|intact:EBI-10045685|intact:EBI-8573308|intact:MINT-8174146|ensembl:ENSMUSP00000088796	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:sc16a_mouse(display_long)|uniprotkb:Sec16a(gene name)|psi-mi:Sec16a(display_short)|uniprotkb:Kiaa0310(gene name synonym)|uniprotkb:SEC16 homolog A(gene name synonym)|uniprotkb:Sec16(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_694765.2|refseq:XP_006497974.1|ensembl:ENSMUSG00000026924(gene)|ensembl:ENSMUST00000091252(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0031090"(organelle membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043000"(Golgi to plasma membrane CFTR protein transport)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR024298|interpro:IPR024340|interpro:IPR024880|mint:E9QAT4|reactome:R-MMU-204005|go:"GO:0032527"(protein exit from endoplasmic reticulum)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:97WhpZFikynLgEykn8l5NJODOpo10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q80U72	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-1766028|uniprotkb:Q6P5H7|uniprotkb:Q7TPH8|uniprotkb:Q80VB1|uniprotkb:Q8CI48|uniprotkb:Q8VII1|uniprotkb:Q922S3|ensembl:ENSMUSP00000068056	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:scrib_mouse(display_long)|uniprotkb:Scrib(gene name)|psi-mi:Scrib(display_short)|uniprotkb:Kiaa0147(gene name synonym)|uniprotkb:Lap4(gene name synonym)|uniprotkb:Scrib1(gene name synonym)|uniprotkb:Protein LAP4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_598850.1|refseq:XP_017171844.1|refseq:NP_001297471.1|refseq:NP_001297472.1|dip:DIP-40660N|ensembl:ENSMUSG00000022568(gene)|ensembl:ENSMUST00000063747(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001843"(neural tube closure)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0008104"(protein localization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016477"(cell migration)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036034|mint:Q80U72|reactome:R-MMU-9013148|reactome:R-MMU-9013406|reactome:R-MMU-9696264|reactome:R-MMU-9696270	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:WF4b5QAjIGIgq6tnexNZtDhI7gk10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q6ZPE2	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-771895|uniprotkb:Q4QQM2|uniprotkb:Q8BK68|uniprotkb:Q8K2Z0|uniprotkb:B2RXQ1|uniprotkb:B2RXX4|uniprotkb:B7ZWK2|ensembl:ENSMUSP00000120725	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:mtmr5_mouse(display_long)|uniprotkb:SET-binding factor 1(gene name synonym)|uniprotkb:Sbf1(gene name)|psi-mi:Sbf1(display_short)|uniprotkb:Kiaa3020(gene name synonym)|uniprotkb:Mtmr5(gene name synonym)|uniprotkb:Inactive phosphatidylinositol 3-phosphatase 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001074499.2|refseq:NP_001164032.1|ensembl:ENSMUSG00000036529(gene)|ensembl:ENSMUST00000123791(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0016604"(nuclear body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001194(DENN)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR004182(GRAM)|interpro:IPR005112(dDENN)|interpro:IPR005113(uDENN)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022096|interpro:IPR029021|interpro:IPR030564|interpro:IPR030574|interpro:IPR037516|interpro:IPR043153|rcsb pdb:1V5U|reactome:R-MMU-1483248|reactome:R-MMU-8876198	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:EXetiIj59Q3tqiAmw422ux9X6NY10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P26043	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-647737|uniprotkb:Q3TS85|uniprotkb:Q9QW27|ensembl:ENSMUSP00000000590|ensembl:ENSMUSP00000128249	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:radi_mouse(display_long)|uniprotkb:ESP10(gene name synonym)|uniprotkb:Rdx(gene name)|psi-mi:Rdx(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001098086.1|refseq:NP_033067.2|dip:DIP-29091N|ensembl:ENSMUSG00000032050(gene)|ensembl:ENSMUST00000000590(transcript)|ensembl:ENSMUST00000163153(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032420"(stereocilium)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0045176"(apical protein localization)|go:"GO:0045177"(apical part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903392"(negative regulation of adherens junction organization)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26043|rcsb pdb:1GC6|rcsb pdb:1GC7|rcsb pdb:1J19|rcsb pdb:2D10|rcsb pdb:2D11|rcsb pdb:2D2Q|rcsb pdb:2EMS|rcsb pdb:2EMT|rcsb pdb:2YVC|rcsb pdb:2ZPY|rcsb pdb:3X23|reactome:R-MMU-437239	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:d7wqsdTau9b92O3q6LW+/pyKL1w10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8C796	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-3043949|ensembl:ENSMUSP00000063335|uniprotkb:Q9JMK4	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:rcor2_mouse(display_long)|uniprotkb:Rcor2(gene name)|psi-mi:Rcor2(display_short)|uniprotkb:M-CoREST(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000024968(gene)|ensembl:ENSMUST00000066646(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|mint:Q8C796|refseq:NP_001307483.1|refseq:NP_473389.2|dip:DIP-59754N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:R+uWIOSogm6HqGyspApSgHyMh1k10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P46061	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-1033051|uniprotkb:Q60801|uniprotkb:Q6NZB5|ensembl:ENSMUSP00000057771|ensembl:ENSMUSP00000126849|ensembl:ENSMUSP00000130046	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ragp1_mouse(display_long)|uniprotkb:Rangap1(gene name)|psi-mi:Rangap1(display_short)|uniprotkb:Fug1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001139646.1|refseq:NP_035371.4|ensembl:ENSMUSG00000022391(gene)|ensembl:ENSMUST00000052374(transcript)|ensembl:ENSMUST00000170134(transcript)|ensembl:ENSMUST00000171115(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46061|rcsb pdb:1KPS|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108232|reactome:R-MMU-4615885|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9615933|reactome:R-MMU-9648025|dip:DIP-17024N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:XrJlIJ7cGqaUyNGBsK1ifk0YbmU10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9ERU9	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-643756|uniprotkb:E9QM01|uniprotkb:Q61992|uniprotkb:Q8C9K9|ensembl:ENSMUSP00000003310	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:rbp2_mouse(display_long)|uniprotkb:Ran-binding protein 2(gene name synonym)|uniprotkb:Ranbp2(gene name)|psi-mi:Ranbp2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_035370.2|reactome:R-MMU-191859|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-4615885|reactome:R-MMU-5578749|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|ensembl:ENSMUSG00000003226(gene)|ensembl:ENSMUST00000003310(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006457"(protein folding)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR022011|interpro:IPR029000|interpro:IPR036443|mint:Q9ERU9|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:cjIAIF0uuxSMRXErJiJc+OBJpAw10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q3TLH4	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-6908845|ensembl:ENSMUSP00000138433|uniprotkb:E9QKG5|uniprotkb:Q05CS4|uniprotkb:Q05DM5|uniprotkb:Q3TKF3|uniprotkb:Q3UXU5|uniprotkb:Q4FZE4|uniprotkb:Q66K03|uniprotkb:Q6P3F4|uniprotkb:Q80TK3|uniprotkb:Q80YR0|uniprotkb:Q8BMJ4|uniprotkb:Q8C1K7|uniprotkb:Q8CGH3	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:prc2c_mouse(display_long)|uniprotkb:Prrc2c(gene name)|psi-mi:Prrc2c(display_short)|uniprotkb:Bat2d(gene name synonym)|uniprotkb:Bat2d1(gene name synonym)|uniprotkb:Bat2l2(gene name synonym)|uniprotkb:Kiaa1096(gene name synonym)|uniprotkb:BAT2 domain-containing protein 1(gene name synonym)|uniprotkb:HLA-B-associated transcript 2-like 2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:XP_011237086.1|ensembl:ENSMUSG00000040225(gene)|ensembl:ENSMUST00000182660(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q3TLH4|refseq:NP_001074759.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:lJHI4KKm0yJpyg2mURs2zCXOrSY10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q7TPM1	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16728307|ensembl:ENSMUSP00000035734|uniprotkb:A2AN31|uniprotkb:Q8C755	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:prc2b_mouse(display_long)|uniprotkb:HLA-B-associated transcript 2-like 1(gene name synonym)|uniprotkb:Proline-rich coiled-coil protein 2B(gene name synonym)|uniprotkb:Prrc2b(gene name)|psi-mi:Prrc2b(display_short)|uniprotkb:Bat2l(gene name synonym)|uniprotkb:Bat2l1(gene name synonym)|uniprotkb:Kiaa0515(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000039262(gene)|ensembl:ENSMUST00000036691(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q7TPM1|refseq:NP_001153106.1|refseq:NP_766249.2	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:WlCA3MFhuVeSWOib983JRtCgwRI10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q7TSC1	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-645425|uniprotkb:Q923A9|uniprotkb:Q9Z1R1|ensembl:ENSMUSP00000025253	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:prc2a_mouse(display_long)|uniprotkb:HLA-B-associated transcript 2(gene name synonym)|uniprotkb:Prrc2a(gene name)|psi-mi:Prrc2a(display_short)|uniprotkb:Bat2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001185973.1|refseq:NP_064411.2|refseq:XP_006524683.1|dip:DIP-49629N|ensembl:ENSMUSG00000024393(gene)|ensembl:ENSMUST00000025253(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q7TSC1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:ktwyGkClOoaD4rZap/xJb/aKj4s10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q80YT7	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9R0L6	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-4284371|uniprotkb:O70287|uniprotkb:Q3URH6|uniprotkb:Q7TMS7|uniprotkb:Q8C9V2|uniprotkb:Q91Y27|uniprotkb:Q91Y28|uniprotkb:Q91Y51|uniprotkb:Q9CRK8|uniprotkb:Q923L0|uniprotkb:Q9CT57|uniprotkb:E9QLK2|ensembl:ENSMUSP00000039709	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:pcm1_mouse(display_long)|uniprotkb:Pcm1(gene name)|psi-mi:Pcm1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_076151.2|refseq:XP_006509361.1|ensembl:ENSMUSG00000031592(gene)|ensembl:ENSMUST00000045218(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q9R0L6|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-380320	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:OT+ZOQY5pqQojMcLCWMIY+6zdl410090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:E9Q3G8	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-11518671|ensembl:ENSMUSP00000021803	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:e9q3g8_mouse(display_long)|uniprotkb:Nup153(gene name)|psi-mi:Nup153(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_786925.2|ensembl:ENSMUSG00000021374(gene)|ensembl:ENSMUST00000021803(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:1990875"(nucleoplasmic side of nuclear pore)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR013913(Nucleoporin, Nup153-like)|interpro:IPR018892|interpro:IPR026054|interpro:IPR036443|reactome:R-MMU-159227|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822|reactome:R-MMU-191859|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-4615885|reactome:R-MMU-5578749|reactome:R-MMU-159230	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:CTxpT3ASQtc6I9zQHrRM4ENxvsw10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9D6Z1	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-527254|uniprotkb:Q3UD45|uniprotkb:Q8BVL1|uniprotkb:Q8VDT2|uniprotkb:Q99LT8|uniprotkb:Q9CT15|ensembl:ENSMUSP00000099487	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:nop56_mouse(display_long)|uniprotkb:Nop56(gene name)|psi-mi:Nop56(display_short)|uniprotkb:Nol5a(gene name synonym)|uniprotkb:Nucleolar protein 5A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_077155.2|ensembl:ENSMUSG00000027405(gene)|ensembl:ENSMUST00000103198(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|interpro:IPR012974(NOP5, N-terminal)|interpro:IPR012976(NOSIC)|interpro:IPR036070|interpro:IPR042239|mint:Q9D6Z1|reactome:R-MMU-6791226	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:5darNL7hBt/XPnvcm0hiVxx7WDY10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q922K7	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16729640|uniprotkb:Q3U4W9	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:nop2_mouse(display_long)|uniprotkb:Nucleolar protein 1(gene name synonym)|uniprotkb:Nucleolar protein 2 homolog(gene name synonym)|uniprotkb:Proliferating-cell nucleolar antigen p120(gene name synonym)|uniprotkb:Proliferation-associated nucleolar protein p120(gene name synonym)|uniprotkb:Nop2(gene name)|psi-mi:Nop2(display_short)|uniprotkb:Nol1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0001510"(RNA methylation)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009383"("rRNA (cytosine-C5-)-methyltransferase activity")|go:"GO:0070475"(rRNA base methylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|mint:Q922K7|interpro:IPR018314|interpro:IPR031341|interpro:IPR001678("Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p")|interpro:IPR011023(Nop2p)|interpro:IPR012586(P120R)|interpro:IPR023267|interpro:IPR023273|interpro:IPR029063	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:BAr9p7p6IhfUcMmdkp8XMMPQsxk10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P08553	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-445188|uniprotkb:A2VCT5|uniprotkb:Q0VDM8|uniprotkb:Q3HRJ6|uniprotkb:Q3TNS4|uniprotkb:Q3TPK2|uniprotkb:Q61961|uniprotkb:Q8BQ20	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:nfm_mouse(display_long)|uniprotkb:Neurofilament triplet M protein(gene name synonym)|uniprotkb:160 kDa neurofilament protein(gene name synonym)|uniprotkb:Neurofilament 3(gene name synonym)|uniprotkb:Nefm(gene name)|psi-mi:Nefm(display_short)|uniprotkb:Nef3(gene name synonym)|uniprotkb:Nfm(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_032717.2|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR002957(Keratin, type I)|interpro:IPR039008|interpro:IPR027697|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030424"(axon)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|mint:P08553	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:2HBUZIEhbbrfamAhbq7gyuRUaTk10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P08551	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-445199|uniprotkb:Q8K0Z0|ensembl:ENSMUSP00000022639	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:nfl_mouse(display_long)|uniprotkb:Neurofilament triplet L protein(gene name synonym)|uniprotkb:68 kDa neurofilament protein(gene name synonym)|uniprotkb:Nefl(gene name)|psi-mi:Nefl(display_short)|uniprotkb:Nfl(gene name synonym)|uniprotkb:Nf68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_035040.1|ensembl:ENSMUSG00000022055(gene)|ensembl:ENSMUST00000022639(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027692|interpro:IPR039008|mint:P08551|reactome:R-MMU-438066|reactome:R-MMU-5673001|go:"GO:0098981"(cholinergic synapse)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0040011"(locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051258"(protein polymerization)|go:"GO:0051412"(response to corticosterone)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060074"(synapse maturation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|dip:DIP-31944N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:E8KK2ppZXyLXIlFZp/pjXv7GBEU10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P46935	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9WU42	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-6673326|ensembl:ENSMUSP00000107029|uniprotkb:E9Q9V0|uniprotkb:Q9WU43|uniprotkb:Q9WUC1	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ncor2_mouse(display_long)|uniprotkb:Ncor2(gene name)|psi-mi:Ncor2(display_short)|uniprotkb:Smrt(gene name synonym)|uniprotkb:Silencing mediator of retinoic acid and thyroid hormone receptor(gene name synonym)|uniprotkb:T3 receptor-associating factor(gene name synonym)|uniprotkb:Thyroid-, retinoic-acid-receptor-associated corepressor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:Q9WU42|reactome:R-MMU-2173795|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-383280|reactome:R-MMU-400206|reactome:R-MMU-9029569|reactome:R-MMU-9623433|reactome:R-MMU-9707564|ensembl:ENSMUSG00000029478(gene)|ensembl:ENSMUST00000111398(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021537"(telencephalon development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0030900"(forebrain development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:XP_011239133.1|refseq:NP_001240833.1|refseq:NP_001240834.1|dip:DIP-42595N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:/OTDXDBeSGySNf9Sfg/BDtf8FDA10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q60974	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-349004|uniprotkb:Q60812	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ncor1_mouse(display_long)|uniprotkb:Ncor1(gene name)|psi-mi:Ncor1(display_short)|uniprotkb:Rxrip13(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0002361"(CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021794"(thalamus development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051225"(spindle assembly)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:0046329"(negative regulation of JNK cascade)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|reactome:R-MMU-2173795|reactome:R-MMU-3214815|reactome:R-MMU-350054|go:"GO:0046965"(retinoid X receptor binding)|reactome:R-MMU-383280|reactome:R-MMU-9029569|reactome:R-MMU-9623433|reactome:R-MMU-9707564|reactome:R-MMU-400206|mint:Q60974|dip:DIP-32548N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:5IfmxD5K9s0dYCZ6AOMwaBDElFs10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q7TSZ8	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-5691985|uniprotkb:Q80X97|uniprotkb:Q9CZ72|ensembl:ENSMUSP00000001975	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:nacc1_mouse(display_long)|uniprotkb:Nacc1(gene name)|psi-mi:Nacc1(display_short)|uniprotkb:Btbd14b(gene name synonym)|uniprotkb:Nac1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein 14B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_080064.3|refseq:XP_006531355.1|refseq:XP_006531356.1|refseq:XP_006531357.1|dip:DIP-29930N|ensembl:ENSMUSG00000001910(gene)|ensembl:ENSMUST00000001975(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030054"(cell junction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018379|mint:Q7TSZ8	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:Mp3o/oidyfj6U+OTJwTb2WP4Q3Y10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q69ZK1	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16728565	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:q69zk1_mouse(display_long)|uniprotkb:N4bp2(gene name)|psi-mi:N4bp2(display_short)|uniprotkb:B3bp(gene name synonym)|uniprotkb:mKIAA1413(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0046404"(polydeoxyribonucleotide 5'-hydroxyl-kinase activity)|refseq:NP_001020088.1|interpro:IPR027417	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:Ie1hxZs2a1OzfMJeY2SwARSbSJE10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8C854	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-4285350|uniprotkb:Q6ZPT3|uniprotkb:Q8QZZ1|uniprotkb:Q60690|uniprotkb:Q6P930|ensembl:ENSMUSP00000123088	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:myef2_mouse(display_long)|uniprotkb:Myef2(gene name)|psi-mi:Myef2(display_short)|uniprotkb:Kiaa1341(gene name synonym)|uniprotkb:Mef2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001155889.1|refseq:XP_006498947.1|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034630|interpro:IPR034631|interpro:IPR034632|interpro:IPR035979|interpro:IPR000504(RNA recognition motif, RNP-1)|mint:Q8C854|ensembl:ENSMUSG00000027201(gene)|ensembl:ENSMUST00000152367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|refseq:XP_017171620.1|refseq:XP_017171621.1|refseq:XP_017171623.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:ZnM8NqQUhlLdO7gzhs09ckrZUPw10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9QZQ1	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-6673595|ensembl:ENSMUSP00000118318	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:afad_mouse(display_long)|uniprotkb:Afdn(gene name)|psi-mi:Afdn(display_short)|uniprotkb:Af6(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:Mllt4(gene name synonym)|uniprotkb:Protein Af-6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000068036(gene)|ensembl:ENSMUST00000139666(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140059"(dendrite arborization)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000159(Ras-association)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR002710(Dilute)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029071|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0030054"(cell junction)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0043296"(apical junction complex)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|interpro:IPR036034|interpro:IPR037977|rcsb pdb:1WLN|rcsb pdb:1WXA|rcsb pdb:3AXA|rcsb pdb:6AMB|reactome:R-MMU-418990|refseq:NP_034936.1|dip:DIP-60737N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:gzoTHL3iU/HoLVKFDiPQjJ6cSxk10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P12025	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16726312|ensembl:ENSMUSP00000028672|ensembl:ENSMUSP00000068413|ensembl:ENSMUSP00000088090|ensembl:ENSMUSP00000106941	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:mk_mouse(display_long)|uniprotkb:Retanoic acid-responsive protein(gene name synonym)|uniprotkb:Retinoic acid-induced differentiation factor(gene name synonym)|uniprotkb:Mdk(gene name)|psi-mi:Mdk(display_short)|uniprotkb:Mk(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000027239(gene)|ensembl:ENSMUST00000028672(transcript)|ensembl:ENSMUST00000069423(transcript)|ensembl:ENSMUST00000090602(transcript)|ensembl:ENSMUST00000111309(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007614"(short-term memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016477"(cell migration)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021681"(cerebellar granular layer development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030421"(defecation)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0042995"(cell projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044849"(estrous cycle)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0048477"(oogenesis)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071673"(positive regulation of smooth muscle cell chemotaxis)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:0106091"(glial cell projection elongation)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:1904036"(negative regulation of epithelial cell apoptotic process)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000762(PTN/MK heparin-binding protein)|interpro:IPR020089|interpro:IPR020090|interpro:IPR020091|interpro:IPR020092|interpro:IPR037122|interpro:IPR038130|refseq:NP_001012335.1|refseq:NP_001012336.1|refseq:NP_001278410.1|refseq:NP_034914.1|dip:DIP-5791N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:lf0KMWJoUzamS1IZ4O3zLc2Aarc10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P97820	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-644181	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:m4k4_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase kinase 4(gene name synonym)|uniprotkb:HPK/GCK-like kinase HGK(gene name synonym)|uniprotkb:Nck-interacting kinase(gene name synonym)|uniprotkb:Map4k4(gene name)|psi-mi:Map4k4(display_short)|uniprotkb:Nik(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001239129.1|refseq:NP_001239130.1|refseq:NP_001239131.1|refseq:NP_032722.2|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-2559580|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032014"(positive regulation of ARF protein signal transduction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-40973N|mint:P97820	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:laMTX6DrOoTz4D8zxLP5ohzqKyw10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q5XJV6	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16726286|uniprotkb:A6BLZ0|uniprotkb:Q52KF1	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:lmtk3_mouse(display_long)|uniprotkb:Apoptosis-associated tyrosine kinase 3(gene name synonym)|uniprotkb:Lemur tyrosine kinase 3(gene name synonym)|uniprotkb:Lmtk3(gene name)|psi-mi:Lmtk3(display_short)|uniprotkb:Aatyk3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:Q5XJV6|refseq:NP_001005511.2|refseq:NP_001277919.1|refseq:XP_006541027.1|refseq:XP_017177816.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:FJgk1CZB0wgIbl5dhC81Wy7TRJE10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P70168	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:B7ZNG0	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16356783|uniprotkb:B2RUB1	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:kif7_mouse(display_long)|uniprotkb:Kif7(gene name)|psi-mi:Kif7(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0003279"(cardiac septum development)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0035904"(aorta development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|go:"GO:0036064"(ciliary basal body)|reactome:R-MMU-5610787|reactome:R-MMU-5632684|dip:DIP-61761N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:WZ5rB98fyn0jmOSroekMVmjUZMM10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P28740	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-776122|uniprotkb:O54744|uniprotkb:Q91W03|ensembl:ENSMUSP00000022204	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:kif2a_mouse(display_long)|uniprotkb:Kif2a(gene name)|psi-mi:Kif2a(display_short)|uniprotkb:Kif2(gene name synonym)|uniprotkb:Kns2(gene name synonym)|uniprotkb:Kinesin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001139251.1|refseq:XP_006517602.1|ensembl:ENSMUSG00000021693(gene)|ensembl:ENSMUST00000022204(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0051301"(cell division)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097228"(sperm principal piece)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P28740|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-6811434|reactome:R-MMU-68877|reactome:R-MMU-9648025|reactome:R-MMU-983189	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:xPWg0rzeKQooA3AM2Ics+e/QnRM10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9QXL2	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-911098|uniprotkb:Q6P5H1|uniprotkb:Q6ZPJ8|uniprotkb:Q8BWZ9|uniprotkb:Q8BXF1|ensembl:ENSMUSP00000085985	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ki21a_mouse(display_long)|uniprotkb:Kif21a(gene name)|psi-mi:Kif21a(display_short)|uniprotkb:Kiaa1708(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001102510.1|refseq:NP_001102511.1|refseq:NP_001102512.1|refseq:NP_057914.2|ensembl:ENSMUSG00000022629(gene)|ensembl:ENSMUST00000088614(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:1990939"|interpro:IPR001680(WD40 repeat)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036322|interpro:IPR036961|mint:Q9QXL2|rcsb pdb:5YAY|rcsb pdb:5YBE|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:PQNGrSKw7f5ThMhMs/glF32RiZs10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9Z2X8	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9Z0R4	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-645386|uniprotkb:Q9R143|uniprotkb:F8VQE5|ensembl:ENSMUSP00000109635	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:itsn1_mouse(display_long)|uniprotkb:EH and SH3 domains protein 1(gene name synonym)|uniprotkb:Itsn1(gene name)|psi-mi:Itsn1(display_short)|uniprotkb:Ese1(gene name synonym)|uniprotkb:Itsn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001103745.1|refseq:NP_034717.2|ensembl:ENSMUSG00000022957(gene)|ensembl:ENSMUST00000114002(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044305"(calyx of Held)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q9Z0R4|rcsb pdb:3HS8|rcsb pdb:3JV3|reactome:R-MMU-193648|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-9013148|reactome:R-MMU-9013406|reactome:R-MMU-9013408	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:naFu4D6P1S+/t5+VVVeb0De8lEg10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9Z1X4	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-6260790|ensembl:ENSMUSP00000065770|uniprotkb:Q8BP80|uniprotkb:Q8K588|uniprotkb:Q8C2H8|uniprotkb:Q812A1|uniprotkb:Q80VD5	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ilf3_mouse(display_long)|uniprotkb:Ilf3(gene name)|psi-mi:Ilf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001264250.1|ensembl:ENSMUSG00000032178(gene)|ensembl:ENSMUST00000067646(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006479"(protein methylation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q9Z1X4|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|rcsb pdb:5DV7|refseq:XP_006510094.1|refseq:NP_001036172.1|refseq:NP_001036173.1|refseq:NP_034691.2|refseq:NP_001264251.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:vxZan3L6NAseX1Ib9Z7MQ82CM3E10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9CXY6	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2312782|uniprotkb:Q3U083|uniprotkb:Q5RKG0|uniprotkb:Q8CCY9|uniprotkb:Q99KS3|ensembl:ENSMUSP00000001042	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ilf2_mouse(display_long)|uniprotkb:Ilf2(gene name)|psi-mi:Ilf2(display_short)|uniprotkb:Nf45(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_080650.1|ensembl:ENSMUSG00000001016(gene)|ensembl:ENSMUST00000001042(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q9CXY6|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|reactome:R-MMU-6798695	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q99ME9	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-4285566|uniprotkb:Q99K16|uniprotkb:Q99P78|uniprotkb:Q9CT02|ensembl:ENSMUSP00000152412	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:gtpb4_mouse(display_long)|uniprotkb:Gtpbp4(gene name)|psi-mi:Gtpbp4(display_short)|uniprotkb:Crfg(gene name synonym)|uniprotkb:Nog1(gene name synonym)|uniprotkb:Chronic renal failure gene protein(gene name synonym)|uniprotkb:GTP-binding protein NGB(gene name synonym)|uniprotkb:Nucleolar GTP-binding protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_081276.2|ensembl:ENSMUSG00000021149(gene)|ensembl:ENSMUST00000222098(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033342"(negative regulation of collagen binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR010674(Nucleolar GTP-binding 1)|interpro:IPR012973(NOG, C-terminal)|interpro:IPR024926|interpro:IPR027417|interpro:IPR031167|interpro:IPR041623|mint:Q99ME9	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:bcJx83SRfrtIzUbasVwCDleHiR010090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9WV60	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-400793|ensembl:ENSMUSP00000023507	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:gsk3b_mouse(display_long)|uniprotkb:Gsk3b(gene name)|psi-mi:Gsk3b(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_062801.1|dip:DIP-32446N|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006983"(ER overload response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014043"(negative regulation of neuron maturation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034452"(dynactin binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:Q9WV60|rcsb pdb:4NU1|rcsb pdb:5AIR|rcsb pdb:6AE3|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3371453|reactome:R-MMU-399956|reactome:R-MMU-4641262|reactome:R-MMU-5250924|reactome:R-MMU-5610785|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046849"(bone remodeling)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0106027"(neuron projection organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904780"(negative regulation of protein localization to centrosome)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|ensembl:ENSMUSG00000022812(gene)|ensembl:ENSMUST00000023507(transcript)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:FKe0WkOBBYU0vIJLmcFNMJ+KVHA10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:B1AS29	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16729610|ensembl:ENSMUSP00000030676|uniprotkb:Q17R20|uniprotkb:Q9JIA8	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:grik3_mouse(display_long)|uniprotkb:Glutamate receptor 7(gene name synonym)|uniprotkb:Grik3(gene name)|psi-mi:Grik3(display_short)|uniprotkb:Glur7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0008066"(glutamate receptor activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-451308|reactome:R-MMU-500657|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|ensembl:ENSMUSG00000001985(gene)|ensembl:ENSMUST00000030676(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007215"(glutamate receptor signaling pathway)|refseq:NP_001074566.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:m3gyZ9qnwgaqLpzPWND6f5mSl6Y10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q5U4C1	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-8839618|uniprotkb:A2AGB6|uniprotkb:Q8BKR8|uniprotkb:Q8BUN4|uniprotkb:Q8BYK9|uniprotkb:Q8CHF4|uniprotkb:Q8R095|ensembl:ENSMUSP00000108769|ensembl:ENSMUSP00000108770|ensembl:ENSMUSP00000108772|ensembl:ENSMUSP00000132225	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:gasp1_mouse(display_long)|uniprotkb:Gprasp1(gene name)|psi-mi:Gprasp1(display_short)|uniprotkb:Kiaa0443(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001004359.1|refseq:NP_001005385.1|refseq:NP_080357.4|ensembl:ENSMUSG00000043384(gene)|ensembl:ENSMUST00000113144(transcript)|ensembl:ENSMUST00000113145(transcript)|ensembl:ENSMUST00000113147(transcript)|ensembl:ENSMUST00000166554(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:r39unzrYWALTcImwNvApQSJvB/010090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:E9PVZ8	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16729583|ensembl:ENSMUSP00000045239	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:e9pvz8_mouse(display_long)|uniprotkb:Golgb1(gene name)|psi-mi:Golgb1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000034243(gene)|ensembl:ENSMUST00000039855(transcript)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR026202|reactome:R-MMU-432722|reactome:R-MMU-6807878|refseq:NP_084311.1|refseq:XP_006522145.1|refseq:XP_006522146.1|refseq:XP_006522147.1|refseq:XP_017172452.1|refseq:XP_017172453.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:yT+HnrljavsLItaxqc/7Gb5eoHc10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P55937	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-647945|uniprotkb:Q80VF5|uniprotkb:Q8CCK4|uniprotkb:Q9QYT2|uniprotkb:Q9QYT3	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:goga3_mouse(display_long)|uniprotkb:Golgin-160(gene name synonym)|uniprotkb:Male-enhanced antigen 2(gene name synonym)|uniprotkb:Golga3(gene name)|psi-mi:Golga3(display_short)|uniprotkb:Mea2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_032172.3|interpro:IPR033288|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030154"(cell differentiation)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0090498"(extrinsic component of Golgi membrane)|reactome:R-MMU-9696270|go:"GO:0007283"(spermatogenesis)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:M2jyN71/zrgSF7nm1pYVLtWr9G410090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9JLQ2	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-642860|uniprotkb:E9QPU7|ensembl:ENSMUSP00000107803	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:git2_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 2(gene name synonym)|uniprotkb:GRK-interacting protein 2(gene name synonym)|uniprotkb:Cool-interacting tyrosine-phosphorylated protein 2(gene name synonym)|uniprotkb:Git2(gene name)|psi-mi:Git2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_062808.3|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q9JLQ2|rcsb pdb:6JMT|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|ensembl:ENSMUSG00000041890(gene)|ensembl:ENSMUST00000112185(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:mOkKto/u8bzW0feEp3Kah7fYeOI10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8VDC1	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16727814|ensembl:ENSMUSP00000081764|ensembl:ENSMUSP00000133222|uniprotkb:Q3V385|uniprotkb:Q7TMT0|uniprotkb:Q8BJN2	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:fyco1_mouse(display_long)|uniprotkb:Fyco1(gene name)|psi-mi:Fyco1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000025241(gene)|ensembl:ENSMUST00000084715(transcript)|ensembl:ENSMUST00000167595(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0072383"(plus-end-directed vesicle transport along microtubule)|go:"GO:1901098"(positive regulation of autophagosome maturation)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR004012(RUN)|interpro:IPR009038(GOLD)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR036598|interpro:IPR037213|interpro:IPR042654|rcsb pdb:5WRD|refseq:NP_001103723.2|refseq:NP_683727.3|refseq:XP_017168648.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:UQrU+0SySU+oBd+pE2OneGw0oog10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q60902	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-443931|ensembl:ENSMUSP00000129739|uniprotkb:Q3U7L9|uniprotkb:Q8CB60|uniprotkb:Q8CB70|uniprotkb:Q3UIS9|uniprotkb:Q91WH8	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ep15r_mouse(display_long)|uniprotkb:Eps15-related protein(gene name synonym)|uniprotkb:Epidermal growth factor receptor pathway substrate 15-related sequence(gene name synonym)|uniprotkb:Eps15l1(gene name)|psi-mi:Eps15l1(display_short)|uniprotkb:Eps15-rs(gene name synonym)|uniprotkb:Eps15R(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000006276(gene)|ensembl:ENSMUST00000163643(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030132"(clathrin coat of coated pit)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q60902|reactome:R-MMU-182971|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_001116304.1|refseq:NP_031970.2|refseq:NP_001276788.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:8Xag/aZPFGDnwUbio3gkHL3nMes10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P42567	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-443923|ensembl:ENSMUSP00000099790|uniprotkb:Q8C431	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:eps15_mouse(display_long)|uniprotkb:Protein AF-1p(gene name synonym)|uniprotkb:Eps15(gene name)|psi-mi:Eps15(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUST00000102729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0046718"(viral entry into host cell)|ensembl:ENSMUSG00000028552(gene)|go:"GO:0060170"(ciliary membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P42567|rcsb pdb:1KYF|rcsb pdb:1KYU|rcsb pdb:1QJT|reactome:R-MMU-182971|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_001153436.1|refseq:NP_031969.1|dip:DIP-29052N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:VmZn/g1//dOm/lWdGU55mTQBOjI10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q3UJB9	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2553526|uniprotkb:Q3U6U8|uniprotkb:Q8R223|uniprotkb:Q7TS78	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:edc4_mouse(display_long)|uniprotkb:Edc4(gene name)|psi-mi:Edc4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|reactome:R-MMU-430039|refseq:NP_001288029.1|interpro:IPR032401|refseq:NP_853625.1|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q3UJB9	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:FVX5K/2axUrzI66j1QPmJsqpxec10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:O08791	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-647994|uniprotkb:O08793|ensembl:ENSMUSP00000147829	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:coe3_mouse(display_long)|uniprotkb:Early B-cell factor 3(gene name synonym)|uniprotkb:Olf-1/EBF-like 2(gene name synonym)|uniprotkb:Ebf3(gene name)|psi-mi:Ebf3(display_short)|uniprotkb:Coe3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001106886.1|refseq:NP_034226.1|interpro:IPR038006|interpro:IPR038173|mint:O08791|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR003523(Transcription factor COE)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR018350|interpro:IPR032200|interpro:IPR032201|ensembl:ENSMUSG00000010476(gene)|ensembl:ENSMUST00000210774(transcript)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:EjmszlImd4hnDec7YLvR1OL3NLo10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P63168	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-349121|uniprotkb:Q15701|ensembl:ENSMUSP00000107720|ensembl:ENSMUSP00000009157|uniprotkb:Q3UGE7	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:dyl1_mouse(display_long)|uniprotkb:Dynll1(gene name)|psi-mi:Dynll1(display_short)|uniprotkb:Dlc1(gene name synonym)|uniprotkb:Dnclc1(gene name synonym)|uniprotkb:Dncl1(gene name synonym)|uniprotkb:Dynein light chain LC8-type 1(gene name synonym)|uniprotkb:8 kDa dynein light chain(gene name synonym)|uniprotkb:Protein inhibitor of neuronal nitric oxide synthase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_062656.3|ensembl:ENSMUST00000009157(transcript)|ensembl:ENSMUST00000112090(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000009013(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006915"(apoptotic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0030141"(secretory granule)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030286"(dynein complex)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|mint:P63168|reactome:R-MMU-111446|reactome:R-MMU-141444|reactome:R-MMU-1632852|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:Bra4LfaqYPMyo6xX9RD6G7Rdv8010090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8R1A4	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-776274|uniprotkb:Q45V78|uniprotkb:Q5PRE6|uniprotkb:Q6PJ17|uniprotkb:Q9CSB6|uniprotkb:Q9CXM7	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:dock7_mouse(display_long)|uniprotkb:Gm430(gene name synonym)|uniprotkb:Dock7(gene name)|psi-mi:Dock7(display_short)|uniprotkb:Kiaa1771(gene name synonym)|uniprotkb:Mnlt(gene name synonym)|uniprotkb:Protein moonlight(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	interpro:IPR027357|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR043162|interpro:IPR043161|interpro:IPR026791|interpro:IPR027007|interpro:IPR035892|interpro:IPR037808|mint:Q8R1A4|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043473"(pigmentation)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|reactome:R-MMU-8875555|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-983231	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:T4W30iJF8XaTuK57c9vlJFr9gpg10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q91WN1	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2657776|uniprotkb:Q3TSG3|uniprotkb:Q8R0E3|ensembl:ENSMUSP00000022345	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:dnjc9_mouse(display_long)|uniprotkb:Dnajc9(gene name)|psi-mi:Dnajc9(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_598842.1|go:"GO:0005829"(cytosol)|ensembl:ENSMUSG00000021811(gene)|ensembl:ENSMUST00000022345(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0005737"(cytoplasm)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:npkrpswDe+pHwlDqgV/B8irW1GA10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P63037	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-772408|uniprotkb:P54102|ensembl:ENSMUSP00000030118|ensembl:ENSMUSP00000129730	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:dnja1_mouse(display_long)|uniprotkb:Heat shock 40 kDa protein 4(gene name synonym)|uniprotkb:DnaJ protein homolog 2(gene name synonym)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:Dnaja1(gene name)|psi-mi:Dnaja1(display_short)|uniprotkb:Dnaj2(gene name synonym)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Hspf4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001158143.1|refseq:NP_001158144.1|refseq:NP_032324.1|dip:DIP-32350N|ensembl:ENSMUSG00000028410(gene)|ensembl:ENSMUST00000030118(transcript)|ensembl:ENSMUST00000164233(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009408"(response to heat)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:1901998"(toxin transport)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:P63037|reactome:R-MMU-3371497	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:gi42F7LF6CiylXZF4fRg/kuM/s010090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P26231	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-647895|ensembl:ENSMUSP00000049007	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ctna1_mouse(display_long)|uniprotkb:102 kDa cadherin-associated protein(gene name synonym)|uniprotkb:CAP102(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Ctnna1(gene name)|psi-mi:Ctnna1(display_short)|uniprotkb:Catna1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_033948.1|refseq:XP_011245120.1|dip:DIP-35299N|ensembl:ENSMUSG00000037815(gene)|ensembl:ENSMUST00000042345(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P26231|rcsb pdb:1DOV|rcsb pdb:1DOW|rcsb pdb:1L7C|rcsb pdb:4E17|rcsb pdb:4E18|rcsb pdb:4K1N|rcsb pdb:5Y04|rcsb pdb:6DV1|rcsb pdb:6O3E|rcsb pdb:6WVT|reactome:R-MMU-418990|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:2GScCoVKWPHfjBJE6Gm6yVmO/IA10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q61164	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-932785|ensembl:ENSMUSP00000005841	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ctcf_mouse(display_long)|uniprotkb:Ctcf(gene name)|psi-mi:Ctcf(display_short)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCFL paralog(gene name synonym)|uniprotkb:11-zinc finger protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_851839.1|refseq:XP_006530711.1|dip:DIP-38020N|ensembl:ENSMUSG00000005698(gene)|ensembl:ENSMUST00000005841(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006306"(DNA methylation)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031060"(regulation of histone methylation)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0040030"(obsolete regulation of molecular function, epigenetic)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071514"(genomic imprinting)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q61164|reactome:R-MMU-212436	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:r9BpKoiLzrCAiQttYFbIIkitePk10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q6ZQ08	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-682479|intact:EBI-2104684|uniprotkb:B2RY28|uniprotkb:Q3UPB7|uniprotkb:Q8BSB4|uniprotkb:Q8BXB2|uniprotkb:Q8C0H2|uniprotkb:Q8K3D8	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:cnot1_mouse(display_long)|uniprotkb:Cnot1(gene name)|psi-mi:Cnot1(display_short)|uniprotkb:Kiaa1007(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_835179.1|refseq:XP_006530937.1|dip:DIP-46845N|mint:Q6ZQ08|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|reactome:R-MMU-429947|reactome:R-MMU-6804115	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:AfCS Y2H protein 39306. Translated from nucleotide sequence.	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:2Q4quoSuPlUbD4QkiAkc9Hr9avI10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q922J3	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-776187|uniprotkb:Q571L7|ensembl:ENSMUSP00000107192	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:clip1_mouse(display_long)|uniprotkb:Restin(gene name synonym)|uniprotkb:Clip1(gene name)|psi-mi:Clip1(display_short)|uniprotkb:Kiaa4046(gene name synonym)|uniprotkb:Rsn(gene name synonym)|uniprotkb:Cytoplasmic linker protein 170(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_062739.2|refseq:NP_001278158.1|ensembl:ENSMUSG00000049550(gene)|ensembl:ENSMUST00000111566(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001726"(ruffle)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042802"(identical protein binding)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0051010"(microtubule plus-end binding)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR032108|interpro:IPR036859|mint:Q922J3|rcsb pdb:2CP7|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:VamQo+KVLXsd4aHycgXJlQF2Bw010090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q80U49	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16728053|ensembl:ENSMUSP00000098580|ensembl:ENSMUSP00000137331|ensembl:ENSMUSP00000152451|uniprotkb:Q3UH33|uniprotkb:Q3UHG1|uniprotkb:Q80UM2	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:c170b_mouse(display_long)|uniprotkb:Centrosomal protein 170B(gene name synonym)|uniprotkb:Cep170b(gene name)|psi-mi:Cep170b(display_short)|uniprotkb:Kiaa0284(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000072825(gene)|ensembl:ENSMUST00000101018(transcript)|ensembl:ENSMUST00000179041(transcript)|ensembl:ENSMUST00000222711(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029300|refseq:NP_001019773.2|refseq:XP_006515829.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:vmI/x564L8rTcob6vkmQLu2+JCQ10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q6A065	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2554140|uniprotkb:Q7TQD9|uniprotkb:Q8BJW2|uniprotkb:Q9D3Z0|ensembl:ENSMUSP00000141793	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ce170_mouse(display_long)|uniprotkb:Kiaa0470(gene name synonym)|uniprotkb:Cep170(gene name)|psi-mi:Cep170(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000057335(gene)|ensembl:ENSMUST00000194727(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q6A065|refseq:XP_006497000.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:gawEp+b6DVpUroRU0JHmHzo7qPg10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q155P7	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2211248	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:q155p7_mouse(display_long)|uniprotkb:Cenpf(gene name)|psi-mi:Cenpf(display_short)|uniprotkb:Lek1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	interpro:IPR019513|interpro:IPR018463|interpro:IPR018302|interpro:IPR043513|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001822"(kidney development)|go:"GO:0002724"(regulation of T cell cytokine production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007507"(heart development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030496"(midbody)|go:"GO:0030885"(regulation of myeloid dendritic cell activation)|go:"GO:0032386"(regulation of intracellular transport)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045120"(pronucleus)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048866"(stem cell fate specification)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0055037"(recycling endosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097539"(ciliary transition fiber)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:b3rPf5eE6WotbUeJcEwHdYF9Gwg10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q6A068	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2552123|ensembl:ENSMUSP00000024727|uniprotkb:Q8K1J9	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:cdc5l_mouse(display_long)|uniprotkb:Cdc5l(gene name)|psi-mi:Cdc5l(display_short)|uniprotkb:Kiaa0432(gene name synonym)|uniprotkb:Cdc5-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000023932(gene)|ensembl:ENSMUST00000024727(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|refseq:NP_690023.1|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904568"(cellular response to wortmannin)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017930|interpro:IPR021786|mint:Q6A068|reactome:R-MMU-72163|go:"GO:0005737"(cytoplasm)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:ehcu1kQlVD4/J1K3a77EcsjqRbI10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q5SNZ0	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-6271994|uniprotkb:Q5M6X2|uniprotkb:Q5M6X4|uniprotkb:Q5M6X5|uniprotkb:Q5SNZ1|uniprotkb:Q8C486|uniprotkb:Q8CFU7	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:grdn_mouse(display_long)|uniprotkb:Ccdc88a(gene name)|psi-mi:Ccdc88a(display_short)|uniprotkb:Grdn(gene name synonym)|uniprotkb:Kiaa1212(gene name synonym)|uniprotkb:Akt phosphorylation enhancer(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 88A(gene name synonym)|uniprotkb:G alpha-interacting vesicle-associated protein(gene name synonym)|uniprotkb:Girders of actin filament(gene name synonym)|uniprotkb:Hook-related protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030142"(COPI-coated Golgi to ER transport vesicle)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0072660"(maintenance of protein location in plasma membrane)|go:"GO:1903566"(positive regulation of protein localization to cilium)|reactome:R-MMU-9696264|reactome:R-MMU-9696273|interpro:IPR036872|refseq:XP_006514518.1|refseq:NP_789811.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR027717|interpro:IPR043936	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:hCoyY8kOqAAJYtIB6uzHpDMDfo010090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8VDP4	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2931660|ensembl:ENSMUSP00000036924|uniprotkb:Q6PIB1|uniprotkb:Q8BWR5|uniprotkb:Q8C0F0|uniprotkb:Q8R3G6	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ccar2_mouse(display_long)|uniprotkb:Ccar2(gene name)|psi-mi:Ccar2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000033712(gene)|ensembl:ENSMUST00000035612(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|interpro:IPR028811|mint:Q8VDP4|reactome:R-MMU-3371453|refseq:NP_666167.3|refseq:XP_006518959.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:4KqmxaC2o3+yWOF9dwQ9kQ7AMqs10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8CH18	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-645246|uniprotkb:Q6AXC9|uniprotkb:Q6PAR2|uniprotkb:Q80XE4|uniprotkb:Q8BJY0|uniprotkb:Q8BVN2|uniprotkb:Q8CGG1|uniprotkb:Q9CSR5|uniprotkb:Q05BR1|uniprotkb:Q05DK6|ensembl:ENSMUSP00000020268|ensembl:ENSMUSP00000151895	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ccar1_mouse(display_long)|uniprotkb:Cell cycle and apoptosis regulatory protein 1(gene name synonym)|uniprotkb:Ccar1(gene name)|psi-mi:Ccar1(display_short)|uniprotkb:Carp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_080477.1|refseq:XP_006514057.1|refseq:XP_006514058.1|refseq:XP_006514059.1|refseq:XP_006514060.1|refseq:XP_011241839.1|ensembl:ENSMUSG00000020074(gene)|ensembl:ENSMUST00000020268(transcript)|ensembl:ENSMUST00000219527(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|interpro:IPR036361|mint:Q8CH18|reactome:R-MMU-72163	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:fipMhp0uguP4AXVte036ScUyq5g10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:B2RQC6	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-3043834|ensembl:ENSMUSP00000013773|uniprotkb:B7ZN27	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:pyr1_mouse(display_long)|uniprotkb:Cad(gene name)|psi-mi:Cad(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000013629(gene)|ensembl:ENSMUST00000013773(transcript)|go:"GO:0002134"(UTP binding)|go:"GO:0004070"(aspartate carbamoyltransferase activity)|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004151"(dihydroorotase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014075"(response to amine)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016597"(amino acid binding)|go:"GO:0017144"|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0001889"(liver development)|go:"GO:0031000"(response to caffeine)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044205"('de novo' UMP biosynthetic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051414"(response to cortisol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR002082(Aspartate carbamoyltransferase, eukaryotic)|interpro:IPR002195(Dihydroorotase, conserved site)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|go:"GO:0019899"(enzyme binding)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR032466|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036901|interpro:IPR036914|mint:B2RQC6|reactome:R-MMU-500753|refseq:NP_076014.1|refseq:NP_001276451.1|dip:DIP-61412N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:t+qQw7me78vEm/Y4VBBhS8fmCsY10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9WVA3	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-1781718|uniprotkb:Q6ZWM5|uniprotkb:P97397|ensembl:ENSMUSP00000081547	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:bub3_mouse(display_long)|uniprotkb:Bub3(gene name)|psi-mi:Bub3(display_short)|uniprotkb:WD repeat type I transmembrane protein A72.5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_033904.2|refseq:NP_001304279.1|ensembl:ENSMUSG00000066979(gene)|ensembl:ENSMUST00000084502(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|mint:Q9WVA3|reactome:R-MMU-141430|reactome:R-MMU-141444|reactome:R-MMU-174184|reactome:R-MMU-176409|reactome:R-MMU-179409|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:09UCXnVgc+bSYbygg0KVJjt9f7c10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8CGN4	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-1216174|uniprotkb:Q6PDK5|uniprotkb:Q6ZPM3|uniprotkb:Q8BKF5|uniprotkb:Q8CGN1|uniprotkb:Q8CGN2|uniprotkb:Q8CGN3|uniprotkb:B1AXK3|uniprotkb:B1AXK4|uniprotkb:B1AXK5|uniprotkb:B1AXK6|ensembl:ENSMUSP00000111175	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:bcor_mouse(display_long)|uniprotkb:Bcor(gene name)|psi-mi:Bcor(display_short)|uniprotkb:Kiaa1575(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001161793.1|refseq:NP_083786.2|refseq:NP_778209.2|refseq:NP_778210.2|refseq:NP_778211.2|refseq:XP_017174110.1|refseq:XP_017174111.1|refseq:XP_017174112.1|refseq:XP_017174113.1|dip:DIP-29852N|ensembl:ENSMUSG00000040363(gene)|ensembl:ENSMUST00000115513(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000415"(negative regulation of histone H3-K36 methylation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007507"(heart development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0042476"(odontogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070171"(negative regulation of tooth mineralization)|go:"GO:0140261"(BCOR complex)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR031628|interpro:IPR032365|interpro:IPR036770|interpro:IPR038227|mint:Q8CGN4|go:"GO:0001835"(blastocyst hatching)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:pP+f/rncs1LPbNu+vOm1Q44oZ3w10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8K019	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2536273|uniprotkb:Q8C2E9|uniprotkb:Q9CSW5|uniprotkb:Q8BNZ0|ensembl:ENSMUSP00000043583	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:bclf1_mouse(display_long)|uniprotkb:Bclaf1(gene name)|psi-mi:Bclaf1(display_short)|uniprotkb:Btf(gene name synonym)|uniprotkb:Kiaa0164(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000037608(gene)|ensembl:ENSMUST00000043881(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR026668|interpro:IPR029199|mint:Q8K019|refseq:NP_001020563.1|refseq:NP_722482.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:+9NQPsUgV77P3yH9iK0ZRDIOioM10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q60875	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-772191|uniprotkb:E9QNW9|uniprotkb:O09115|uniprotkb:Q3TBI4|uniprotkb:Q3TJ16|uniprotkb:Q8CHE1|uniprotkb:Q923E0|uniprotkb:Q9ESG7|ensembl:ENSMUSP00000029694	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:arhg2_mouse(display_long)|uniprotkb:Kiaa0651(gene name synonym)|uniprotkb:Lbcl1(gene name synonym)|uniprotkb:Lfc(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Lymphoid blast crisis-like 1(gene name synonym)|uniprotkb:LBC'S first cousin(gene name synonym)|uniprotkb:Oncogene LFC(gene name synonym)|uniprotkb:Rhobin(gene name synonym)|uniprotkb:Arhgef2(gene name)|psi-mi:Arhgef2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001185840.1|refseq:NP_001185841.1|refseq:NP_001185842.1|refseq:NP_032513.3|refseq:XP_006501130.1|ensembl:ENSMUSG00000028059(gene)|ensembl:ENSMUST00000029694(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002102"(podosome)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071802"(negative regulation of podosome assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037806|interpro:IPR041020|mint:Q60875|rcsb pdb:5WI4|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:Le4PMm1AT/ManVpetNT2wBsUlok10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9DBG3	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-775229|uniprotkb:Q80XJ4|ensembl:ENSMUSP00000070714	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ap2b1_mouse(display_long)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:Ap2b1(gene name)|psi-mi:Ap2b1(display_short)|uniprotkb:Clapb1(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001030931.1|refseq:NP_082191.1|refseq:XP_006534321.1|refseq:XP_017170261.1|dip:DIP-32161N|ensembl:ENSMUSG00000035152(gene)|ensembl:ENSMUST00000065692(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0035904"(aorta development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q9DBG3|rcsb pdb:6OWO|rcsb pdb:6OXL|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:YWwOqRpXCJDwzrLv27muBx1+DHI10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:O08583	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-6464301|ensembl:ENSMUSP00000026125|uniprotkb:Q0VBL5|uniprotkb:Q8CBM4|uniprotkb:Q9JJW7	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:thoc4_mouse(display_long)|uniprotkb:Alyref(gene name)|psi-mi:Alyref(display_short)|uniprotkb:Aly(gene name synonym)|uniprotkb:Ref1(gene name synonym)|uniprotkb:Refbp1(gene name synonym)|uniprotkb:THOC4(gene name synonym)|uniprotkb:Ally of AML-1 and LEF-1(gene name synonym)|uniprotkb:Aly/REF export factor(gene name synonym)|uniprotkb:REF1-I(gene name synonym)|uniprotkb:RNA and export factor-binding protein 1(gene name synonym)|uniprotkb:Transcriptional coactivator Aly/REF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000025134(gene)|ensembl:ENSMUST00000026125(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0051028"(mRNA transport)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR025715|interpro:IPR035979|mint:O08583|rcsb pdb:1NO8|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|refseq:NP_035698.1|dip:DIP-59977N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:DZAvcQrp7S1uipKsc/Wpxgb+gJI10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q70FJ1	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-645887|uniprotkb:Q3TH74|uniprotkb:Q80TR6	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:akap9_mouse(display_long)|uniprotkb:Akap9(gene name)|psi-mi:Akap9(display_short)|uniprotkb:Kiaa0803(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_919444.2|interpro:IPR019528|interpro:IPR028745|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007165"(signal transduction)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034705"(potassium channel complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044307"(dendritic branch)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097729"(9+2 motile cilium)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0120219"(subapical part of cell)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903358"(regulation of Golgi organization)|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5576890|reactome:R-MMU-5576893|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:Q70FJ1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:9yyCeoX35wNULJg413iGM9TIQxA10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9DBR0	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-4285802|uniprotkb:Q9R0L8|ensembl:ENSMUSP00000002699	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:akap8_mouse(display_long)|uniprotkb:Akap8(gene name)|psi-mi:Akap8(display_short)|uniprotkb:Akap95(gene name synonym)|uniprotkb:A-kinase anchor protein 95 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000024045(gene)|ensembl:ENSMUST00000002699(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001939"(female pronucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033127"(regulation of histone phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044839"(cell cycle G2/M phase transition)|go:"GO:0045087"(innate immune response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|interpro:IPR007071("A-kinase anchoring protein 95 (AKAP95)")|interpro:IPR034736|mint:Q9DBR0|refseq:NP_062748.2	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:CboiIO6b/r8YM0jLmJbCdzg5S3U10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q3UHJ0	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-771618|uniprotkb:B2RUJ0|uniprotkb:Q3TY53|uniprotkb:Q6ZPZ6|uniprotkb:Q80XP6|ensembl:ENSMUSP00000086948	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:aak1_mouse(display_long)|uniprotkb:Adaptor-associated kinase 1(gene name synonym)|uniprotkb:Aak1(gene name)|psi-mi:Aak1(display_short)|uniprotkb:Kiaa1048(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001035195.1|refseq:NP_808430.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030136"(clathrin-coated vesicle)|ensembl:ENSMUSG00000057230(gene)|ensembl:ENSMUST00000089519(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0071439"(clathrin complex)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q3UHJ0|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:VdUCkCmofdJSa676n0jLS8VLDso10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9EPU0	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-6876715|ensembl:ENSMUSP00000075089|uniprotkb:Q3UG00|uniprotkb:Q6GYP5|uniprotkb:Q6PHQ5|uniprotkb:Q8K0N4|uniprotkb:Q99PR4	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:rent1_mouse(display_long)|uniprotkb:Upf1(gene name)|psi-mi:Upf1(display_short)|uniprotkb:Rent1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000058301(gene)|ensembl:ENSMUST00000075666(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q9EPU0|reactome:R-MMU-975956|reactome:R-MMU-975957|go:"GO:0042162"(telomeric DNA binding)|refseq:XP_006509667.1|refseq:XP_006509668.1|refseq:NP_001116301.1|refseq:NP_109605.2|dip:DIP-60114N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:rwd4XXdf5Uqjtgao/zILckKP8AM10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P70399	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-769130|uniprotkb:Q68FD0|uniprotkb:Q8CI97|uniprotkb:Q91YC9|intact:EBI-11051502|intact:EBI-11516626|uniprotkb:A2AU89|uniprotkb:A2AU91|ensembl:ENSMUSP00000106278	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:tp53b_mouse(display_long)|uniprotkb:Tp53bp1(gene name)|psi-mi:Tp53bp1(display_short)|uniprotkb:Trp53bp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001277759.1|refseq:NP_038763.3|dip:DIP-31595N|refseq:XP_011237883.1|ensembl:ENSMUSG00000043909(gene)|ensembl:ENSMUST00000110648(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:P70399|rcsb pdb:1SSF|reactome:R-MMU-3232118|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:z5tOHbR6ApNZRL9aptim/xRaVo010090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8BYI9	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-774167|uniprotkb:A2RT70|uniprotkb:O88717|ensembl:ENSMUSP00000107298|ensembl:ENSMUSP00000141553	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:tenr_mouse(display_long)|uniprotkb:Restrictin(gene name synonym)|uniprotkb:Janusin(gene name synonym)|uniprotkb:Neural recognition molecule J1-160/180(gene name synonym)|uniprotkb:Tnr(gene name)|psi-mi:Tnr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_071707.2|refseq:XP_006496805.1|refseq:XP_006496806.1|refseq:XP_006496807.1|ensembl:ENSMUSG00000015829(gene)|ensembl:ENSMUST00000111669(transcript)|ensembl:ENSMUST00000192069(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0045121"(membrane raft)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048692"(negative regulation of axon extension involved in regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072534"(perineuronal net)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098966"(perisynaptic extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR033079|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:Q8BYI9|reactome:R-MMU-3000178	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:K7s7yPGS4RvIe+thCkAZIFGjNRA10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q6NSW3	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16729561|uniprotkb:Q8BYQ9|uniprotkb:Q8BZL6|uniprotkb:Q8C1G7|uniprotkb:Q6PAM6|uniprotkb:Q6PAP7|uniprotkb:Q80TA7|uniprotkb:Q80XT3	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:spkap_mouse(display_long)|uniprotkb:SPHK1-interactor and AKAP domain-containing protein(gene name synonym)|uniprotkb:Sphkap(gene name)|psi-mi:Sphkap(display_short)|uniprotkb:Kiaa1678(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0030018"(Z disc)|go:"GO:0051018"(protein kinase A binding)|interpro:IPR018292|interpro:IPR008382(A-kinase anchor 110 kDa)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:DKkb7/cR8wF9R84aOhgk9nP5hqg10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P35979	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-1634002|uniprotkb:Q9CQK4|ensembl:ENSMUSP00000117461	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:rl12_mouse(display_long)|uniprotkb:Rpl12(gene name)|psi-mi:Rpl12(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_033102.2|ensembl:ENSMUSG00000038900(gene)|ensembl:ENSMUST00000126610(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|interpro:IPR000911(Ribosomal protein L11)|interpro:IPR020783|interpro:IPR020784|interpro:IPR020785|interpro:IPR036769|interpro:IPR036796|mint:P35979|rcsb pdb:1WIB|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:elKEi15MO82sKMmT/YFoHw+8SZI10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P42669	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-773823|ensembl:ENSMUSP00000059404	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:pura_mouse(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:Pura(gene name)|psi-mi:Pura(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_033015.1|refseq:XP_006525787.1|refseq:XP_011245162.1|ensembl:ENSMUSG00000043991(gene)|ensembl:ENSMUST00000051301(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:P42669	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:3LVZ5qdZYeJyeUVPhy3cozxROWs10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P60469	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-774674|uniprotkb:B8QI35|ensembl:ENSMUSP00000003961|ensembl:ENSMUSP00000148200	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:lipa3_mouse(display_long)|uniprotkb:Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3(gene name synonym)|uniprotkb:Ppfia3(gene name)|psi-mi:Ppfia3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:XP_006541336.1|refseq:XP_011249214.1|refseq:NP_084017.2|ensembl:ENSMUSG00000003863(gene)|ensembl:ENSMUST00000003961(transcript)|ensembl:ENSMUST00000211067(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0045202"(synapse)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050808"(synapse organization)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098875"(epididymosome)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR029515|interpro:IPR030440|interpro:IPR037620|interpro:IPR037621|interpro:IPR037622|rcsb pdb:4UWX|rcsb pdb:6KIP|rcsb pdb:6KR4|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-388844	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:5KJyS7thzh+Th0r52lh+DKeqOrA10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q61036	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-457317|uniprotkb:O88645|uniprotkb:Q8K1R5|uniprotkb:Q8K1R6|ensembl:ENSMUSP00000033640|ensembl:ENSMUSP00000108484	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:pak3_mouse(display_long)|uniprotkb:p21-activated kinase 3(gene name synonym)|uniprotkb:Beta-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-B(gene name synonym)|uniprotkb:Pak3(gene name)|psi-mi:Pak3(display_short)|uniprotkb:Pak-3(gene name synonym)|uniprotkb:Pakb(gene name synonym)|uniprotkb:Stk4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001181977.1|refseq:NP_001181978.1|refseq:NP_032804.2|refseq:XP_006528815.1|refseq:XP_006528816.1|refseq:XP_006528817.1|ensembl:ENSMUSG00000031284(gene)|ensembl:ENSMUST00000033640(transcript)|ensembl:ENSMUST00000112863(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007409"(axonogenesis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035063|interpro:IPR036936|mint:Q61036|rcsb pdb:1EES|reactome:R-MMU-202433|reactome:R-MMU-389359|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013420|refseq:XP_011246092.1|refseq:XP_017173912.1|dip:DIP-447N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:k1UVGUhqDWyM/nwHNvpkKxUzheo10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:O88643	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-457240	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:pak1_mouse(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-A(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)|uniprotkb:Paka(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-445144|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|dip:DIP-32847N|mint:O88643	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:96Cg20ZJuaGLWTlK9dOIdVHQLGQ10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P29341	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-773902|uniprotkb:Q99L36|ensembl:ENSMUSP00000001809	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:pabp1_mouse(display_long)|uniprotkb:Pabpc1(gene name)|psi-mi:Pabpc1(display_short)|uniprotkb:Pabp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	dip:DIP-32127N|refseq:NP_032800.2|refseq:XP_011243641.1|ensembl:ENSMUSG00000022283(gene)|ensembl:ENSMUST00000001809(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045202"(synapse)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P29341|reactome:R-MMU-156827|reactome:R-MMU-429947|reactome:R-MMU-450408|reactome:R-MMU-72649|reactome:R-MMU-975956|reactome:R-MMU-975957	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:jvlQW6kphF2tkZwK72DtAXDPHvs10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P46660	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-400482|uniprotkb:Q61958|uniprotkb:Q8VCW5|ensembl:ENSMUSP00000041347	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ainx_mouse(display_long)|uniprotkb:Ina(gene name)|psi-mi:Ina(display_short)|uniprotkb:66 kDa neurofilament protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_666212.3|ensembl:ENSMUSG00000034336(gene)|ensembl:ENSMUST00000037636(transcript)|go:"GO:0005883"(neurofilament)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027703|interpro:IPR039008|mint:P46660	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:amjP0AajB8s2oXmV96wzyfz6evE10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P38647	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-772469|uniprotkb:Q9CQ05|intact:EBI-4282065|uniprotkb:Q3TW93|uniprotkb:Q3UVN1|uniprotkb:Q3V015|intact:EBI-1635058|uniprotkb:Q7TSZ0|ensembl:ENSMUSP00000025217	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:grp75_mouse(display_long)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:p66 MOT(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:Hspa9(gene name)|psi-mi:Hspa9(display_short)|uniprotkb:Grp75(gene name synonym)|uniprotkb:Hsp74(gene name synonym)|uniprotkb:Hspa9a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_034611.2|ensembl:ENSMUSG00000024359(gene)|ensembl:ENSMUST00000025217(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P38647|reactome:R-MMU-3371453	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:HyohIe5BGD5mW3UO0OekqUKOhbU10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8VEK3	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-529674|uniprotkb:Q9R205|uniprotkb:G3XA10|ensembl:ENSMUSP00000047571	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:hnrpu_mouse(display_long)|uniprotkb:Hnrpu(gene name synonym)|uniprotkb:Hnrnpu(gene name)|psi-mi:Hnrnpu(display_short)|uniprotkb:Scaffold-attachment factor A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:XP_017177162.1|refseq:XP_017177163.1|refseq:NP_058085.2|refseq:XP_017177161.1|dip:DIP-34257N|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q8VEK3|reactome:R-MMU-72163|reactome:R-MMU-72203|ensembl:ENSMUSG00000039630(gene)|ensembl:ENSMUST00000037748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:ONBrFPHIT3aP6XnUgJMf4qiu8VQ10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9D0E1	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-773789|uniprotkb:Q6P1B2|uniprotkb:Q99JQ0|ensembl:ENSMUSP00000120115	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:hnrpm_mouse(display_long)|uniprotkb:Hnrpm(gene name synonym)|uniprotkb:Hnrnpm(gene name)|psi-mi:Hnrnpm(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001103383.1|refseq:NP_084080.1|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979|mint:Q9D0E1|reactome:R-MMU-6803529|reactome:R-MMU-72163|reactome:R-MMU-72203|ensembl:ENSMUSG00000059208(gene)|ensembl:ENSMUST00000148178(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0048306"(calcium-dependent protein binding)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:VpoWJwPx1uDzAsBxM3/TfiCMGok10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P61979	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-299907|ensembl:ENSMUSP00000039269|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q60577|uniprotkb:Q8BGQ8|uniprotkb:Q922Y7|uniprotkb:Q96J62	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:hnrpk_mouse(display_long)|uniprotkb:Hnrnpk(gene name)|psi-mi:Hnrnpk(display_short)|uniprotkb:Hnrpk(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUST00000043269(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0002102"(podosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|ensembl:ENSMUSG00000021546(gene)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1990715"(mRNA CDS binding)|go:"GO:1990829"(C-rich single-stranded DNA binding)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000173"(negative regulation of branching morphogenesis of a nerve)|interpro:IPR004087(K Homology)|go:"GO:0051117"(ATPase binding)|go:"GO:0060999"(positive regulation of dendritic spine development)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61979|reactome:R-MMU-4570464|reactome:R-MMU-72163|reactome:R-MMU-72203|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904322"(cellular response to forskolin)|refseq:NP_001288269.1|refseq:NP_001288270.1|refseq:NP_001288272.1|refseq:NP_001288273.1|refseq:NP_001288274.1|refseq:XP_017170884.1|refseq:XP_017170885.1|refseq:NP_079555.1|refseq:XP_006517166.1|refseq:XP_006517167.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	intact:EBI-16729545	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	-	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:d3z5m2_mouse(display_short)|psi-mi:EBI-16729545(display_long)|uniprotkb:Gm10110(gene name)|psi-mi:Gm10110(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	uniprotkb:D3Z5M2(uniprot-removed-ac)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:O/ivQERUYThPb1qaGo/DZQFzlBs10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q68FF6	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-645933|ensembl:ENSMUSP00000037210	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P35922	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-645094	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9WUA2	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-11707271|uniprotkb:Q9CWZ8|ensembl:ENSMUSP00000069508|ensembl:ENSMUSP00000129828	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:syfb_mouse(display_long)|uniprotkb:Farsb(gene name)|psi-mi:Farsb(display_short)|uniprotkb:Farsl(gene name synonym)|uniprotkb:Farslb(gene name synonym)|uniprotkb:Frsb(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase beta subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001265004.1|refseq:NP_035941.2|ensembl:ENSMUSG00000026245(gene)|ensembl:ENSMUST00000068333(transcript)|ensembl:ENSMUST00000170217(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0009328"(phenylalanine-tRNA ligase complex)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR004531(Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR005147(tRNA synthetase, B5)|interpro:IPR009061(Putative DNA binding)|interpro:IPR020825|interpro:IPR040659|mint:Q9WUA2|interpro:IPR041616	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:qdABVIohiIx9CxsmlBUUYXMkRh810090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8C0C7	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-4286479|uniprotkb:Q3U3Q9|uniprotkb:Q91WR4|uniprotkb:Q922S1|ensembl:ENSMUSP00000003906	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:syfa_mouse(display_long)|uniprotkb:Farsa(gene name)|psi-mi:Farsa(display_short)|uniprotkb:Farsla(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase alpha subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_079924.2|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0009328"(phenylalanine-tRNA ligase complex)|ensembl:ENSMUSG00000003808(gene)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR002319(Phenylalanyl-tRNA synthetase, class IIc)|interpro:IPR004529(Phenylalanyl-tRNA synthetase, class IIc, alpha subunit)|ensembl:ENSMUST00000003906(transcript)|go:"GO:0000049"(tRNA binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR036390|interpro:IPR040586|interpro:IPR040724|interpro:IPR040725|mint:Q8C0C7	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:BSyxrw9ab0HyAuktFxcgvTKUOKE10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8C163	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-16729525|ensembl:ENSMUSP00000035094|uniprotkb:Q3UFL2	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:exog_mouse(display_long)|uniprotkb:Endonuclease G-like 1(gene name synonym)|uniprotkb:Exog(gene name)|psi-mi:Exog(display_short)|uniprotkb:Endogl1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR020821|interpro:IPR040255|ensembl:ENSMUSG00000042787(gene)|ensembl:ENSMUST00000035094(transcript)|interpro:IPR041003|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0008409"(5'-3' exonuclease activity)|refseq:NP_766044.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:4NmdlTEgBLC0GaMD/onwJ4G4A2Q10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9WV92	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-911885|uniprotkb:Q69ZT8|ensembl:ENSMUSP00000079098|uniprotkb:Q9R102	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:e41l3_mouse(display_long)|uniprotkb:4.1B(gene name synonym)|uniprotkb:Differentially expressed in adenocarcinoma of the lung protein 1(gene name synonym)|uniprotkb:Epb41l3(gene name)|psi-mi:Epb41l3(display_short)|uniprotkb:Dal1(gene name synonym)|uniprotkb:Epb4.1l3(gene name synonym)|uniprotkb:Kiaa0987(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000024044(gene)|ensembl:ENSMUST00000080208(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043217"(myelin maintenance)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030691|interpro:IPR035963|mint:Q9WV92|reactome:R-MMU-6794361|refseq:NP_038841.1|refseq:XP_011244586.1|refseq:XP_011244591.1|refseq:XP_017172724.1|refseq:XP_017172725.1	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:51gkxiswTUqQbAUqjGoPthWD7jM10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P70372	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-6877056|ensembl:ENSMUSP00000096549|ensembl:ENSMUSP00000146866|uniprotkb:Q60745|uniprotkb:Q78QY3	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:elav1_mouse(display_long)|uniprotkb:Elavl1(gene name)|psi-mi:Elavl1(display_short)|uniprotkb:Elra(gene name synonym)|uniprotkb:Hua(gene name synonym)|uniprotkb:Elav-like generic protein(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym)|uniprotkb:MelG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	ensembl:ENSMUSG00000040028(gene)|ensembl:ENSMUST00000098950(transcript)|ensembl:ENSMUST00000209010(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:P70372|reactome:R-MMU-450520|reactome:R-MMU-72163|go:"GO:0019901"(protein kinase binding)|refseq:XP_006508761.1|refseq:NP_034615.2|dip:DIP-46480N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:iKHrpZqi5b7EFLkfVJSRTpi9sj010090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8CJG1	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-2291996|uniprotkb:A1L365|ensembl:ENSMUSP00000095498|ensembl:ENSMUSP00000159361	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ago1_mouse(display_long)|uniprotkb:Ago1(gene name)|psi-mi:Ago1(display_short)|uniprotkb:Argonaute RISC catalytic component 1(gene name synonym)|uniprotkb:Eif2c1(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 1(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_700452.2|refseq:NP_001304102.1|ensembl:ENSMUSG00000041530(gene)|ensembl:ENSMUST00000097888(transcript)|ensembl:ENSMUST00000239428(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070578"(RISC-loading complex)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG1|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:l/WmIsnfJjifEOoxOyG9zDo2ljQ10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q02248	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P15116	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-397974|uniprotkb:Q64260|uniprotkb:Q6GU11|intact:EBI-2255565|ensembl:ENSMUSP00000025166	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:cadh2_mouse(display_long)|uniprotkb:Cdh2(gene name)|psi-mi:Cdh2(display_short)|uniprotkb:Neural cadherin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_031690.3|ensembl:ENSMUSG00000024304(gene)|ensembl:ENSMUST00000025166(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030315"(T-tubule)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|interpro:IPR027397|interpro:IPR030051|interpro:IPR039808|mint:P15116|rcsb pdb:1NCG|rcsb pdb:1NCH|rcsb pdb:1NCI|rcsb pdb:1NCJ|rcsb pdb:1OP4|rcsb pdb:2QVI|rcsb pdb:3Q2W|rcsb pdb:4NUM|rcsb pdb:4NUP|rcsb pdb:4NUQ|reactome:R-MMU-381426|reactome:R-MMU-418990|reactome:R-MMU-525793|reactome:R-MMU-8957275|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090497"(mesenchymal cell migration)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|go:"GO:0043005"(neuron projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|dip:DIP-31564N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:Yon1udPwyvjKP2+GVGUcrsZtFng10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q60865	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-647767|uniprotkb:Q6IMN3|uniprotkb:Q7TT26|uniprotkb:Q60758|uniprotkb:Q61620|ensembl:ENSMUSP00000028607|ensembl:ENSMUSP00000106777	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:capr1_mouse(display_long)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:Caprin1(gene name)|psi-mi:Caprin1(display_short)|uniprotkb:Gpiap(gene name synonym)|uniprotkb:Gpiap1(gene name synonym)|uniprotkb:Gpip137(gene name synonym)|uniprotkb:M11s1(gene name synonym)|uniprotkb:G5E5(orf name)|uniprotkb:Rng105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001104759.1|refseq:NP_001104760.1|refseq:NP_001104761.1|refseq:NP_001104762.1|refseq:NP_058019.2|ensembl:ENSMUSG00000027184(gene)|ensembl:ENSMUST00000028607(transcript)|ensembl:ENSMUST00000111147(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q60865	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:e+Dcb+82jx+CoLhlGBbdSG62dPU10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P28652	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P11798	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q8BKX1	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q9ES28	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P17427	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-775215|uniprotkb:Q8C2J5|uniprotkb:Q921V0|ensembl:ENSMUSP00000003038	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ap2a2_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)|uniprotkb:Adtab(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_031485.3|dip:DIP-32160N|ensembl:ENSMUSG00000002957(gene)|ensembl:ENSMUST00000003038(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030141"(secretory granule)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:P17427|rcsb pdb:1B9K|rcsb pdb:1KY6|rcsb pdb:1KY7|rcsb pdb:1KYD|rcsb pdb:1KYF|rcsb pdb:1KYU|rcsb pdb:1QTP|rcsb pdb:1QTS|rcsb pdb:1W80|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VJ0|rcsb pdb:3HS8|rcsb pdb:6OWO|rcsb pdb:6OXL|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-6798695|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:KlOjm5d8qxxQkcuD2Hukoj8DLss10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:P17426	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-775189|ensembl:ENSMUSP00000082519|ensembl:ENSMUSP00000127842	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:ap2a1_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Ap2a1(gene name)|psi-mi:Ap2a1(display_short)|uniprotkb:Adtaa(gene name synonym)|uniprotkb:Clapa1(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_001070732.1|refseq:NP_031484.1|ensembl:ENSMUSG00000060279(gene)|ensembl:ENSMUST00000085399(transcript)|ensembl:ENSMUST00000166972(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0032433"(filopodium tip)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:P17426|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:Dd6Q+Et/LTlmo5qpro2Zaeq0dMc10090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q61584	uniprotkb:Q810B6	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	intact:EBI-11042880|uniprotkb:O54807|uniprotkb:B1ATS3|uniprotkb:Q80UH8|uniprotkb:Q80TG6|ensembl:ENSMUSP00000118751	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:anfy1_mouse(display_long)|uniprotkb:Ankfy1(gene name)|psi-mi:Ankfy1(display_short)|uniprotkb:Ankhzn(gene name synonym)|uniprotkb:Ankyrin repeat and FYVE domain-containing protein 1(gene name synonym)|uniprotkb:Ankyrin repeats hooked to a zinc finger motif(gene name synonym)|uniprotkb:Kiaa1255(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16729686|imex:IM-26285-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	refseq:NP_033801.4|ensembl:ENSMUSG00000020790(gene)|ensembl:ENSMUST00000155998(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0030904"(retromer complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044354"(macropinosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002110(Ankyrin)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR020683|interpro:IPR036770|mint:Q810B6|reactome:R-MMU-9013405	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rogid:J7Z8nPJUWXjezacdXU/8bqZ/MS410090	rigid:AyVdIBmb/fLZ3jfbJAK2BHV3Elw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q91X43	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-2024543|uniprotkb:O08635|uniprotkb:O35146|uniprotkb:Q8C7I2|ensembl:ENSMUSP00000103291|ensembl:ENSMUSP00000138320|ensembl:ENSMUSP00000158600|ensembl:ENSMUSP00000158775	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:sh319_mouse(display_long)|uniprotkb:Sh3d19(gene name)|psi-mi:Sh3d19(display_short)|uniprotkb:Kryn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_001075883.2|ensembl:ENSMUSG00000028082(gene)|ensembl:ENSMUST00000107664(transcript)|ensembl:ENSMUST00000182666(transcript)|ensembl:ENSMUST00000238222(transcript)|ensembl:ENSMUST00000238331(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR001452(Src homology-3)|interpro:IPR035834|interpro:IPR035835|interpro:IPR036028|reactome:R-MMU-432722	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:H9y/y3ClfrgC1SSBI/1pD0CliVs10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q8VBX6	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-8026435|uniprotkb:Q8VBV5|uniprotkb:Q6P7U4|uniprotkb:Q8VBY0|uniprotkb:B7ZNA1|uniprotkb:Q9Z1K3|uniprotkb:O08783|uniprotkb:Q8BKJ1|uniprotkb:Q8C0H8|intact:MINT-146667|uniprotkb:Q80ZY8|ensembl:ENSMUSP00000099894	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:mpdz_mouse(display_long)|uniprotkb:Mpdz(gene name)|psi-mi:Mpdz(display_short)|uniprotkb:Mupp1(gene name synonym)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_001292213.1|refseq:NP_001292215.1|refseq:NP_034950.2|dip:DIP-41165N|ensembl:ENSMUSG00000028402(gene)|ensembl:ENSMUST00000102830(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042552"(myelination)|go:"GO:0043220"(Schmidt-Lanterman incisure)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:Q8VBX6|rcsb pdb:4XH7	-	-	comment:mint|function:Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:PE6FMj7RyxofEiUpGMu97CF+TX810090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:E9Q0S6	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-8792524|ensembl:ENSMUSP00000127715	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:e9q0s6_mouse(display_long)|uniprotkb:Tns1(gene name)|psi-mi:Tns1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	ensembl:ENSMUSG00000055322(gene)|ensembl:ENSMUST00000169786(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0010761"(fibroblast migration)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|refseq:NP_082160.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:NwxyQLlVTkwCu60tx4fMp2LZmwc10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q68FG2	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-2255511|ensembl:ENSMUSP00000008991	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:q68fg2_mouse(display_long)|uniprotkb:Sptbn2(gene name)|psi-mi:Sptbn2(display_short)|uniprotkb:Spnb3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_067262.1|refseq:XP_006531767.1|refseq:XP_006531768.1|ensembl:ENSMUSG00000067889(gene)|ensembl:ENSMUST00000008991(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008091"(spectrin)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0030534"(adult behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051693"(actin filament capping)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098918"(structural constituent of synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:0099189"(postsynaptic spectrin-associated cytoskeleton)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-MMU-2132295|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:2F7U0dl21KxXpc9Z2sk7D/wzQvM10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q62261	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q6NSW3	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-16729561|uniprotkb:Q8BYQ9|uniprotkb:Q8BZL6|uniprotkb:Q8C1G7|uniprotkb:Q6PAM6|uniprotkb:Q6PAP7|uniprotkb:Q80TA7|uniprotkb:Q80XT3	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:spkap_mouse(display_long)|uniprotkb:SPHK1-interactor and AKAP domain-containing protein(gene name synonym)|uniprotkb:Sphkap(gene name)|psi-mi:Sphkap(display_short)|uniprotkb:Kiaa1678(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0030018"(Z disc)|go:"GO:0051018"(protein kinase A binding)|interpro:IPR018292|interpro:IPR008382(A-kinase anchor 110 kDa)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:DKkb7/cR8wF9R84aOhgk9nP5hqg10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q9QXN0	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-16730174|uniprotkb:Q3TNX1|uniprotkb:Q6ZPP9|uniprotkb:Q99L16|uniprotkb:Q9QXM9	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:shrm3_mouse(display_long)|uniprotkb:Shroom3(gene name)|psi-mi:Shroom3(display_short)|uniprotkb:Kiaa1481(gene name synonym)|uniprotkb:Shrm(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	go:"GO:0000902"(cell morphogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0002066"(columnar/cuboidal epithelial cell development)|go:"GO:0003779"(actin binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005912"(adherens junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007389"(pattern specification process)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0043296"(apical junction complex)|go:"GO:0043482"(cellular pigment accumulation)|go:"GO:0045176"(apical protein localization)|go:"GO:0045177"(apical part of cell)|go:"GO:0051015"(actin filament binding)|refseq:NP_001071063.1|refseq:NP_001071064.1|refseq:NP_056571.2|refseq:XP_006535031.1|interpro:IPR014800(Apx/shroom, ASD1)|interpro:IPR014799(Apx/shroom, ASD2)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR030494|interpro:IPR027685	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:rgquHwQRrYULMKAz/JZSvvTMNkc10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q4ACU6	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q8R550	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-642709|uniprotkb:Q8CAL8|uniprotkb:Q8CEF6|uniprotkb:Q8R545|uniprotkb:Q8R546|uniprotkb:Q8R547|uniprotkb:Q8R548|uniprotkb:Q8R549|uniprotkb:Q8R551|uniprotkb:Q9CTQ9|uniprotkb:Q9DC14|uniprotkb:Q9JKC3|uniprotkb:B1AZ86|uniprotkb:B1AZ87|ensembl:ENSMUSP00000072840	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:sh3k1_mouse(display_long)|uniprotkb:SH3-containing, expressed in tumorigenic astrocytes(gene name synonym)|uniprotkb:Regulator of ubiquitous kinase(gene name synonym)|uniprotkb:Sh3kbp1(gene name)|psi-mi:Sh3kbp1(display_short)|uniprotkb:Ruk(gene name synonym)|uniprotkb:Seta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_001129199.1|refseq:NP_001129200.1|refseq:NP_067364.2|refseq:XP_006528987.1|ensembl:ENSMUSG00000040990(gene)|ensembl:ENSMUST00000073094(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q8R550|rcsb pdb:1WI7|rcsb pdb:2DA9|rcsb pdb:5XHZ|reactome:R-MMU-182971|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866376|reactome:R-MMU-983695|refseq:XP_011246151.1|refseq:XP_011246153.1|refseq:NP_001277590.1|refseq:NP_001277593.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:Fd7WikE+fZIgob7Ax2vr9J291N010090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:P47708	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-398376|ensembl:ENSMUSP00000078198|ensembl:ENSMUSP00000143917|ensembl:ENSMUSP00000144291	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:rp3a_mouse(display_long)|uniprotkb:Rph3a(gene name)|psi-mi:Rph3a(display_short)|uniprotkb:Exophilin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_035416.1|ensembl:ENSMUSG00000029608(gene)|ensembl:ENSMUST00000079204(transcript)|ensembl:ENSMUST00000202326(transcript)|ensembl:ENSMUST00000202406(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008430"(selenium binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098981"(cholinergic synapse)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR028698|interpro:IPR035892|interpro:IPR041282|interpro:IPR043566|mint:P47708|rcsb pdb:2K3H|refseq:NP_001289273.1|refseq:NP_001289274.1|go:"GO:0030141"(secretory granule)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:DQu/fNNUJTlaqFv34SIBVEw6sZk10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q68EF0	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-16730154|ensembl:ENSMUSP00000020375	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:rab3i_mouse(display_long)|uniprotkb:Rabin-3(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym)|uniprotkb:Rab3ip(gene name)|psi-mi:Rab3ip(display_short)|uniprotkb:Rabin8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	ensembl:ENSMUSG00000064181(gene)|ensembl:ENSMUST00000020375(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0030027"(lamellipodium)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0042802"(identical protein binding)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051020"(GTPase binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1990635"(proximal dendrite)|interpro:IPR040351|mint:Q68EF0|reactome:R-MMU-5620912|reactome:R-MMU-5620916|reactome:R-MMU-5620922|reactome:R-MMU-8876198|go:"GO:0070319"(Golgi to plasma membrane transport vesicle)|refseq:NP_001003950.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:vJqpNpn2gSYd/89uDKCBOO/KQDs10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:P12849	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-645585|ensembl:ENSMUSP00000026973|ensembl:ENSMUSP00000106515	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:kap1_mouse(display_long)|uniprotkb:Prkar1b(gene name)|psi-mi:Prkar1b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_032949.3|refseq:XP_006504723.1|refseq:XP_006504724.1|refseq:XP_006504726.1|refseq:NP_001240819.1|refseq:XP_017176208.1|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0030552"(cAMP binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|go:"GO:0009887"(animal organ morphogenesis)|interpro:IPR018488|interpro:IPR018490|interpro:IPR042818|mint:P12849|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720|reactome:R-MMU-5610787|reactome:R-MMU-983231|ensembl:ENSMUSG00000025855(gene)|ensembl:ENSMUST00000026973(transcript)|ensembl:ENSMUST00000110890(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007611"(learning or memory)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:w65y6gB5uVAjfKjbAidQPpWtgAo10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q9DBC7	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-645677|uniprotkb:Q3UKU7|uniprotkb:Q9JHR5|uniprotkb:Q9JHR6|ensembl:ENSMUSP00000056500|ensembl:ENSMUSP00000102288	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:kap0_mouse(display_long)|uniprotkb:Prkar1a(gene name)|psi-mi:Prkar1a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_001300902.1|refseq:NP_001300903.1|refseq:NP_001300904.1|refseq:NP_001300905.1|refseq:NP_068680.1|refseq:XP_017169829.1|dip:DIP-32450N|ensembl:ENSMUSG00000020612(gene)|ensembl:ENSMUST00000049527(transcript)|ensembl:ENSMUST00000106677(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007507"(heart development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-983231|reactome:R-MMU-5610787|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:Q9DBC7|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|go:"GO:0043949"(regulation of cAMP-mediated signaling)|reactome:R-MMU-442720	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:0KqlQxZjK8QfS6VPEiTDtvHNTj410090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q8C437	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q61036	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-457317|uniprotkb:O88645|uniprotkb:Q8K1R5|uniprotkb:Q8K1R6|ensembl:ENSMUSP00000033640|ensembl:ENSMUSP00000108484	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:pak3_mouse(display_long)|uniprotkb:p21-activated kinase 3(gene name synonym)|uniprotkb:Beta-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-B(gene name synonym)|uniprotkb:Pak3(gene name)|psi-mi:Pak3(display_short)|uniprotkb:Pak-3(gene name synonym)|uniprotkb:Pakb(gene name synonym)|uniprotkb:Stk4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_001181977.1|refseq:NP_001181978.1|refseq:NP_032804.2|refseq:XP_006528815.1|refseq:XP_006528816.1|refseq:XP_006528817.1|ensembl:ENSMUSG00000031284(gene)|ensembl:ENSMUST00000033640(transcript)|ensembl:ENSMUST00000112863(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007409"(axonogenesis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035063|interpro:IPR036936|mint:Q61036|rcsb pdb:1EES|reactome:R-MMU-202433|reactome:R-MMU-389359|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013420|refseq:XP_011246092.1|refseq:XP_017173912.1|dip:DIP-447N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:k1UVGUhqDWyM/nwHNvpkKxUzheo10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:O88643	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-457240	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:pak1_mouse(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-A(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)|uniprotkb:Paka(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-445144|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|dip:DIP-32847N|mint:O88643	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:96Cg20ZJuaGLWTlK9dOIdVHQLGQ10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q04690	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-397326|uniprotkb:Q61956|uniprotkb:Q61957|ensembl:ENSMUSP00000071289	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:nf1_mouse(display_long)|uniprotkb:Nf1(gene name)|psi-mi:Nf1(display_short)|uniprotkb:Neurofibromatosis-related protein NF-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_035027.1|refseq:XP_006532504.1|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0008542"(visual learning)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0021510"(spinal cord development)|go:"GO:0021764"(amygdala development)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0021915"(neural tube development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0045685"(regulation of glial cell differentiation)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023152|interpro:IPR036865|interpro:IPR039360|mint:Q04690|go:"GO:0030424"(axon)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035021"(negative regulation of Rac protein signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045545"(syndecan binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|ensembl:ENSMUSG00000020716(gene)|ensembl:ENSMUST00000071325(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001656"(metanephros development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007154"(cell communication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|reactome:R-MMU-5658442	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:aegHzgNy813/APoCjeM166e+MFE10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q9ESN9	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-301496|uniprotkb:Q99KU7|uniprotkb:Q9EQD8|uniprotkb:Q9ESN7|uniprotkb:Q9ESN8|uniprotkb:Q9ESP0|uniprotkb:Q9JLH2|uniprotkb:Q9JLH3|uniprotkb:Q9R0U7|uniprotkb:Q5D062|ensembl:ENSMUSP00000085683|ensembl:ENSMUSP00000114802	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:jip3_mouse(display_long)|uniprotkb:Syd2(gene name synonym)|uniprotkb:Mapk8ip3(gene name)|psi-mi:Mapk8ip3(display_short)|uniprotkb:Jip3(gene name synonym)|uniprotkb:Jsap1(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 3(gene name synonym)|uniprotkb:JNK/SAPK-associated protein 1(gene name synonym)|uniprotkb:Sunday driver 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	ensembl:ENSMUSG00000024163(gene)|ensembl:ENSMUST00000088345(transcript)|ensembl:ENSMUST00000146923(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007411"(axon guidance)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008104"(protein localization)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030673"(axolemma)|go:"GO:0030900"(forebrain development)|go:"GO:0031103"(axon regeneration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0061564"(axon development)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019143|interpro:IPR032486|interpro:IPR034743|interpro:IPR034744|interpro:IPR036322|interpro:IPR039911|mint:Q9ESN9|rcsb pdb:6EJN|refseq:NP_001156919.1|refseq:NP_001156920.1|refseq:NP_001156921.1|refseq:NP_001156923.1|refseq:NP_038959.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:cY52UF0SczUqoiT9Cnb97na8cLg10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q9ERE9	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-74576|ensembl:ENSMUSP00000023291|uniprotkb:Q9CXI4	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:jip2_mouse(display_long)|uniprotkb:Mapk8ip2(gene name)|psi-mi:Mapk8ip2(display_short)|uniprotkb:Ib2(gene name synonym)|uniprotkb:Jip2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	ensembl:ENSMUSG00000022619(gene)|ensembl:ENSMUST00000023291(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007254"(JNK cascade)|go:"GO:0035176"(social behavior)|go:"GO:0007617"(mating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|interpro:IPR001452(Src homology-3)|go:"GO:0019894"(kinesin binding)|interpro:IPR006020(Phosphotyrosine interaction region)|go:"GO:0019901"(protein kinase binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q9ERE9|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|refseq:NP_068740.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:NUVswDC52pSAuf8BL8b9wqVc8ng10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q9WVI9	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-74515|ensembl:ENSMUSP00000050773|uniprotkb:O35145|uniprotkb:Q925J8|uniprotkb:Q9R1H9|uniprotkb:Q9R1Z1|uniprotkb:Q9WVI7|uniprotkb:Q9WVI8	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:jip1_mouse(display_long)|uniprotkb:Mapk8ip1(gene name)|psi-mi:Mapk8ip1(display_short)|uniprotkb:Ib1(gene name synonym)|uniprotkb:Jip1(gene name synonym)|uniprotkb:Mapk8ip(gene name synonym)|uniprotkb:Prkm8ip(gene name synonym)|uniprotkb:Islet-brain-1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 1(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007165"(signal transduction)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044302"(dentate gyrus mossy fiber)|go:"GO:0045202"(synapse)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035638|interpro:IPR036028|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3V3V|rcsb pdb:6F5E|go:"GO:0005078"(MAP-kinase scaffold activity)|ensembl:ENSMUST00000050312(transcript)|ensembl:ENSMUSG00000027223(gene)|refseq:NP_035292.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:r8Xy/vpp0kYLCZ7vw1sE666dk/g10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q5DTY9	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-6271974|ensembl:ENSMUSP00000089547|ensembl:ENSMUSP00000158201|uniprotkb:Q78Y50	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:kcd16_mouse(display_long)|uniprotkb:Kctd16(gene name)|psi-mi:Kctd16(display_short)|uniprotkb:Gm1267(gene name synonym)|uniprotkb:Kiaa1317(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	ensembl:ENSMUSG00000051401(gene)|ensembl:ENSMUST00000091927(transcript)|ensembl:ENSMUST00000236889(transcript)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0043235"(receptor complex)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|refseq:NP_080411.1|refseq:XP_017173425.1|refseq:XP_017173426.1|refseq:XP_017173427.1|refseq:XP_017173428.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:zwueT9a7iunyYziWGHoKiD8luq810090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q6WVG3	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-16730134|uniprotkb:Q3T9E3	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:kcd12_mouse(display_long)|uniprotkb:Pfetin(gene name synonym)|uniprotkb:Predominantly fetal expressed T1 domain(gene name synonym)|uniprotkb:Kctd12(gene name)|psi-mi:Kctd12(display_short)|uniprotkb:Pfet1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043235"(receptor complex)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051260"(protein homooligomerization)|mint:Q6WVG3|refseq:NP_808383.3|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:5S5rFCAvBhZVG47OqS29CXJxXP810090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:O70507	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-10820097	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:hcn4_mouse(display_long)|uniprotkb:Hcn4(gene name)|psi-mi:Hcn4(display_short)|uniprotkb:Bcng3(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	reactome:R-MMU-1296061|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR014710(RmlC-like jelly roll fold)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:H36ljqPJjhZaCP61Q1savGScDxs10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:O88703	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q9WV60	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-400793|ensembl:ENSMUSP00000023507	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:gsk3b_mouse(display_long)|uniprotkb:Gsk3b(gene name)|psi-mi:Gsk3b(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_062801.1|dip:DIP-32446N|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006983"(ER overload response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014043"(negative regulation of neuron maturation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034452"(dynactin binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:Q9WV60|rcsb pdb:4NU1|rcsb pdb:5AIR|rcsb pdb:6AE3|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3371453|reactome:R-MMU-399956|reactome:R-MMU-4641262|reactome:R-MMU-5250924|reactome:R-MMU-5610785|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046849"(bone remodeling)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0106027"(neuron projection organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904780"(negative regulation of protein localization to centrosome)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|ensembl:ENSMUSG00000022812(gene)|ensembl:ENSMUST00000023507(transcript)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:FKe0WkOBBYU0vIJLmcFNMJ+KVHA10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q8BUV3	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-771218|uniprotkb:E9QKJ1|ensembl:ENSMUSP00000054064	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:geph_mouse(display_long)|uniprotkb:Gphn(gene name)|psi-mi:Gphn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_766540.2|ensembl:ENSMUSG00000047454(gene)|ensembl:ENSMUST00000052472(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0010038"(response to metal ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018315"(molybdenum incorporation into molybdenum-molybdopterin complex)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061598"(molybdopterin adenylyltransferase activity)|go:"GO:0061599"(molybdopterin molybdotransferase activity)|go:"GO:0072579"(glycine receptor clustering)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099144"(anchored component of synaptic membrane)|go:"GO:0099572"(postsynaptic specialization)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR005110(MoeA, N-terminal, domain I and II)|interpro:IPR005111(MoeA, C-terminal, domain IV)|interpro:IPR008284(Molybdenum cofactor biosynthesis, conserved site)|interpro:IPR036135|interpro:IPR036425|interpro:IPR036688|interpro:IPR038987|mint:Q8BUV3|reactome:R-MMU-947581	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:lOuhzjy/8/eDNnV08I0WbLvRiiA10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q68FF6	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-645933|ensembl:ENSMUSP00000037210	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q80T41	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-770749|uniprotkb:A2AL05|ensembl:ENSMUSP00000103378	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:gabr2_mouse(display_long)|uniprotkb:Gm425(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_001074610.1|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|ensembl:ENSMUSG00000039809(gene)|ensembl:ENSMUST00000107749(transcript)|go:"GO:0043005"(neuron projection)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR041689|mint:Q80T41|reactome:R-MMU-1296041|reactome:R-MMU-418594|reactome:R-MMU-420499|reactome:R-MMU-977444|reactome:R-MMU-997272	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:dnGUhfo2YtDMx5QT5gsiVKPUYlw10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q9ERC8	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-1798601|ensembl:ENSMUSP00000056040	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:dscam_mouse(display_long)|uniprotkb:Dscam(gene name)|psi-mi:Dscam(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_112451.1|ensembl:ENSMUSG00000050272(gene)|ensembl:ENSMUST00000056102(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010842"(retina layer formation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0060060"(post-embryonic retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990890"(netrin receptor binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033027|interpro:IPR036116|interpro:IPR036179|interpro:IPR043204|reactome:R-MMU-376172|interpro:IPR013106(Immunoglobulin V-set)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:F74WFvqir5+tLwnp/1ypg0GA0Os10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q811D0	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-514290|uniprotkb:Q62402|uniprotkb:Q6PGB5|uniprotkb:Q8CGN7|ensembl:ENSMUSP00000097581|ensembl:ENSMUSP00000110859	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:dlg1_mouse(display_long)|uniprotkb:Synapse-associated protein 97(gene name synonym)|uniprotkb:Embryo-dlg/synapse-associated protein 97(gene name synonym)|uniprotkb:Dlg1(gene name)|psi-mi:Dlg1(display_short)|uniprotkb:Dlgh1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_031888.2|refseq:NP_001239362.1|refseq:NP_001239364.1|refseq:XP_006521831.1|refseq:NP_001239363.1|dip:DIP-31591N|ensembl:ENSMUSG00000022770(gene)|ensembl:ENSMUST00000100001(transcript)|ensembl:ENSMUST00000115205(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034629"|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043219"(lateral loop)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060022"(hard palate development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1902473"(regulation of protein localization to synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903286"(regulation of potassium ion import)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903760"(regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:1903764"(regulation of potassium ion export across plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR015143(L27-1)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q811D0|rcsb pdb:4OAJ|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-8849932	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:b8LjYbiuR2K6/jxhwU1hxBJKX6410090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q60737	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-771698|uniprotkb:Q8R0X4|ensembl:ENSMUSP00000096829	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:csk21_mouse(display_long)|uniprotkb:Csnk2a1(gene name)|psi-mi:Csnk2a1(display_short)|uniprotkb:Ckiia(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_031814.2|refseq:XP_011237574.1|refseq:XP_006498720.1|dip:DIP-32409N|ensembl:ENSMUSG00000074698(gene)|ensembl:ENSMUST00000099224(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q60737|reactome:R-MMU-1483191|reactome:R-MMU-201688|reactome:R-MMU-2514853|reactome:R-MMU-445144|reactome:R-MMU-6804756|reactome:R-MMU-6814122|reactome:R-MMU-8934903|reactome:R-MMU-8939243|reactome:R-MMU-8948751	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:7UK+lLG3t/3xJi7CaiGSCIcxfPg10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:P16330	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-772515|uniprotkb:Q61424|uniprotkb:Q8C7C9|uniprotkb:Q91V42|uniprotkb:Q923F3|ensembl:ENSMUSP00000099409	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:cn37_mouse(display_long)|uniprotkb:Cnp(gene name)|psi-mi:Cnp(display_short)|uniprotkb:Cnp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_001139790.1|refseq:NP_034053.2|refseq:XP_017169734.1|ensembl:ENSMUSG00000006782(gene)|ensembl:ENSMUST00000103120(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003723"(RNA binding)|go:"GO:0004113"(2',3'-cyclic-nucleotide 3'-phosphodiesterase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009214"(cyclic nucleotide catabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030551"(cyclic nucleotide binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031143"(pseudopodium)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|interpro:IPR008431(Cyclic nucleotide phosphodiesterase)|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|interpro:IPR027417|mint:P16330|rcsb pdb:2XMI|rcsb pdb:2Y1P|rcsb pdb:2Y3X|rcsb pdb:2YDB|rcsb pdb:2YDC|rcsb pdb:2YDD|rcsb pdb:2YOZ|rcsb pdb:2YP0|rcsb pdb:2YPC|rcsb pdb:2YPE|rcsb pdb:2YPH|rcsb pdb:2YQ9|rcsb pdb:3ZBR|rcsb pdb:3ZBS|rcsb pdb:3ZBZ|rcsb pdb:4WBI|rcsb pdb:4WBL|rcsb pdb:4WC9|rcsb pdb:4WCA|rcsb pdb:4WCB|rcsb pdb:4WCC|rcsb pdb:4WDA|rcsb pdb:4WDB|rcsb pdb:4WDD|rcsb pdb:4WDE|rcsb pdb:4WDF|rcsb pdb:4WDG|rcsb pdb:4WDH|rcsb pdb:4WEX|rcsb pdb:4WFR|rcsb pdb:5AE0	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:z0XniuUAwQzaZTvQmEmctKYNw9810090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:P49025	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-397301|intact:EBI-487846|uniprotkb:O88528|uniprotkb:O88937|uniprotkb:O88938|uniprotkb:Q3UM99|uniprotkb:Q8CIJ1	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:ctro_mouse(display_long)|uniprotkb:Cit(gene name)|psi-mi:Cit(display_short)|uniprotkb:Rho-interacting, serine/threonine-protein kinase 21(gene name synonym)|uniprotkb:Crik(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR017405(Citron Rho-interacting kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|refseq:XP_006530214.1|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001726"(ruffle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR037708|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005856"(cytoskeleton)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048699"(generation of neurons)|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-5625900	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:8kykadVIiyk12GjGCZNn0bQ13C010090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:P28652	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:P11798	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:O88737	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-400493|uniprotkb:Q6ZQB5|uniprotkb:E9QMZ3|ensembl:ENSMUSP00000035208	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:bsn_mouse(display_long)|uniprotkb:Bsn(gene name)|psi-mi:Bsn(display_short)|uniprotkb:Kiaa0434(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_031593.2|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045202"(synapse)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0050808"(synapse organization)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099526"(presynapse to nucleus signaling pathway)|go:"GO:1904071"(presynaptic active zone assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:1990257"(piccolo-bassoon transport vesicle)|interpro:IPR008899(Zinc finger, piccolo-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR030627|mint:O88737|ensembl:ENSMUSG00000032589(gene)|ensembl:ENSMUST00000035208(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|refseq:XP_006511697.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:W4w0sRW518SHtgLQ/mY/unJDgwc10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q6NXK8	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-16354652|ensembl:ENSMUSP00000023758|uniprotkb:Q50K97	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:asic1_mouse(display_long)|uniprotkb:Asic1(gene name)|psi-mi:Asic1(display_short)|uniprotkb:Accn2(gene name synonym)|uniprotkb:Acid-sensing ion channel(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 2, neuronal(gene name synonym)|uniprotkb:Asic(gene name synonym)|uniprotkb:Bnac2(gene name synonym)|uniprotkb:Brain sodium channel 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	ensembl:ENSMUSG00000023017(gene)|ensembl:ENSMUST00000023758(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0007613"(memory)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010447"(response to acidic pH)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022839"(ion gated channel activity)|go:"GO:0022890"(inorganic cation transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044736"(acid-sensing ion channel activity)|go:"GO:0045202"(synapse)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071467"(cellular response to pH)|go:"GO:0098662"(inorganic cation transmembrane transport)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-MMU-2672351|dip:DIP-29728N|refseq:NP_001276720.1|refseq:NP_033727.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:rjWzRnh4tP5ilR7Xeomjl0SL2oo10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88704	uniprotkb:Q9ES28	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730213|imex:IM-26285-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	rigid:4U2GTNe2+lsqkZvbxr4RuH/pC/Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:O08759	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-8322563|uniprotkb:E9QKT1|uniprotkb:Q8CE29|intact:MINT-4139156|uniprotkb:P97482|ensembl:ENSMUSP00000143859	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:ube3a_mouse(display_long)|uniprotkb:Ube3a(gene name)|psi-mi:Ube3a(display_short)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:XP_011249149.1|refseq:NP_035798.2|refseq:NP_766598.1|refseq:XP_006540862.1|refseq:XP_017177614.1|ensembl:ENSMUST00000200758(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032570"(response to progesterone)|go:"GO:0035037"(sperm entry)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|ensembl:ENSMUSG00000025326(gene)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061743"(motor learning)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1905528"(positive regulation of Golgi lumen acidification)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000569(HECT)|interpro:IPR017134(Ubiquitin-protein ligase E6-AP)|interpro:IPR032353|interpro:IPR035983|interpro:IPR042556|mint:O08759|reactome:R-MMU-983168|go:"GO:0060736"(prostate gland growth)	-	-	function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:2T49sX43ue2zYCuOb1tHIMyLKY010090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:P83510	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	-	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:E9QAP7	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-8663048|ensembl:ENSMUSP00000038610|intact:MINT-8188815	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:e9qap7_mouse(display_long)|uniprotkb:Taf4(gene name)|psi-mi:Taf4(display_short)|uniprotkb:Taf4a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000039117(gene)|ensembl:ENSMUST00000041618(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0071339"(MLL1 complex)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR007900(Transcription initiation factor TFIID component TAF4)|interpro:IPR009072(Histone-fold)|interpro:IPR037249|reactome:R-MMU-674695|reactome:R-MMU-6804756|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-76042|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001074561.1	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:88++QPPyoCsZBO72Vdg8W16M+hI10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q61818	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-8357942|uniprotkb:Q8CEV1|uniprotkb:Q6ZPH7|uniprotkb:B1AU87|intact:MINT-4131713|ensembl:ENSMUSP00000070896|ensembl:ENSMUSP00000099749|ensembl:ENSMUSP00000126183	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:rai1_mouse(display_long)|uniprotkb:Rai1(gene name)|psi-mi:Rai1(display_short)|uniprotkb:Kiaa1820(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_033047.2|refseq:NP_001032853.1|ensembl:ENSMUSG00000062115(gene)|ensembl:ENSMUST00000064190(transcript)|ensembl:ENSMUST00000102688(transcript)|ensembl:ENSMUST00000171108(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|mint:Q61818	-	-	function:May function as a transcriptional regulator. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:j9wiUBlT7kIxyGFlhvWkXHLiry810090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:O88491	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-8458701|uniprotkb:Q9CT70|intact:MINT-1177495|uniprotkb:Q8C480	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:nsd1_mouse(display_long)|uniprotkb:Nsd1(gene name)|psi-mi:Nsd1(display_short)|uniprotkb:H3-K36-HMTase(gene name synonym)|uniprotkb:Nuclear receptor-binding SET domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	interpro:IPR019786|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR019787|interpro:IPR001841(Zinc finger, RING-type)|mint:O88491|interpro:IPR041306|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000414"(regulation of histone H3-K36 methylation)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016571"(histone methylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042799"("histone methyltransferase activity (H4-K20 specific)")|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0046975"("histone methyltransferase activity (H3-K36 specific)")|go:"GO:0050681"(androgen receptor binding)|go:"GO:1903025"(regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|rcsb pdb:2NAA|reactome:R-MMU-3214841|interpro:IPR000313(PWWP)|interpro:IPR001214(SET)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR006560(AWS)	-	-	comment:mint|function:"Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of negatively influencing transcription. May also positively influence transcription. Essential for early post-implantation development"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:wOa4/D7lTx2PM49k32iLquXLM1o10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q6P9L6	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-8586561|ensembl:ENSMUSP00000035490|uniprotkb:Q70MX5|uniprotkb:O35065|intact:UNK-5482037	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:kif15_mouse(display_long)|uniprotkb:Klp2(gene name synonym)|uniprotkb:Knsl7(gene name synonym)|uniprotkb:Kinesin-like protein 2(gene name synonym)|uniprotkb:Kinesin-like protein 7(gene name synonym)|uniprotkb:Kif15(gene name)|psi-mi:Kif15(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000036768(gene)|ensembl:ENSMUST00000040717(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR031794|interpro:IPR036961|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189|refseq:NP_034750.1	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:apHySN9WwHHX9Qh/HQGQbfPA22E10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q8K2Q9	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-8345422|uniprotkb:Q8C4F6|uniprotkb:Q5DTW5|intact:MINT-4117450|ensembl:ENSMUSP00000041378	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:shot1_mouse(display_long)|uniprotkb:Shtn1(gene name)|psi-mi:Shtn1(display_short)|uniprotkb:Kiaa1598(gene name synonym)|uniprotkb:Shootin1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_001107784.1|refseq:NP_780381.1|ensembl:ENSMUSG00000041362(gene)|ensembl:ENSMUST00000047511(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019894"(kinesin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060327"(cytoplasmic actin-based contraction involved in cell motility)|go:"GO:0061163"(endoplasmic reticulum polarization)|go:"GO:0061573"(actin filament bundle retrograde transport)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR024849|mint:Q8K2Q9	-	-	comment:mint|function:"Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K Activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:yznEpNOVpIXGoX9hyI+UuiA6elY10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q61584	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	-	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q9JJ28	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-7996161|uniprotkb:Q8K095|uniprotkb:Q8VI44|intact:MINT-4095146|ensembl:ENSMUSP00000002889	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:flii_mouse(display_long)|uniprotkb:Flii(gene name)|psi-mi:Flii(display_short)|uniprotkb:Fli1(gene name synonym)|uniprotkb:Fliih(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_071292.1|dip:DIP-47641N|ensembl:ENSMUSG00000002812(gene)|ensembl:ENSMUST00000002889(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030239"(myofibril assembly)|go:"GO:0034451"(centriolar satellite)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR025875|interpro:IPR029006|interpro:IPR029919|interpro:IPR032675|interpro:IPR036180|mint:Q9JJ28	-	-	comment:mint|function:"May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling (By similarity). Essential for early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:wCG18Ps+gmkZd+I52mICu1O1SdQ10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q9WUM4	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-8316222|ensembl:ENSMUSP00000004646|intact:MINT-4091604|uniprotkb:Q8VCQ5|uniprotkb:Q499X7	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:cor1c_mouse(display_long)|uniprotkb:Coro1c(gene name)|psi-mi:Coro1c(display_short)|uniprotkb:Coronin-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000004530(gene)|ensembl:ENSMUST00000004646(transcript)|go:"GO:0000147"(actin cortical patch assembly)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016197"(endosomal transport)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0090148"(membrane fission)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097750"(endosome membrane tubulation)|go:"GO:0140285"(endosome fission)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027333|interpro:IPR036322|mint:Q9WUM4|refseq:NP_035909.2	-	-	comment:mint|function:May be involved in cytokinesis, motility, and signal transduction	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:Td/jSJSpQwBMVL43ZWfzJdkcURA10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q9EPU0	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-6876715|ensembl:ENSMUSP00000075089|uniprotkb:Q3UG00|uniprotkb:Q6GYP5|uniprotkb:Q6PHQ5|uniprotkb:Q8K0N4|uniprotkb:Q99PR4	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:rent1_mouse(display_long)|uniprotkb:Upf1(gene name)|psi-mi:Upf1(display_short)|uniprotkb:Rent1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000058301(gene)|ensembl:ENSMUST00000075666(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q9EPU0|reactome:R-MMU-975956|reactome:R-MMU-975957|go:"GO:0042162"(telomeric DNA binding)|refseq:XP_006509667.1|refseq:XP_006509668.1|refseq:NP_001116301.1|refseq:NP_109605.2|dip:DIP-60114N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:rwd4XXdf5Uqjtgao/zILckKP8AM10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:A2AN08	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-4285947|uniprotkb:A2AN07|uniprotkb:A2AN09|uniprotkb:A2AN10|uniprotkb:A2AN11|uniprotkb:Q52KI4|uniprotkb:Q6PB49|uniprotkb:Q6PFC7|uniprotkb:Q80Y11|uniprotkb:Q8BGB9|uniprotkb:Q8C3E8|uniprotkb:Q8C4W5|uniprotkb:Q8C8X7|uniprotkb:Q8CGE0|uniprotkb:Q8CHF3|ensembl:ENSMUSP00000095433	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:ubr4_mouse(display_long)|uniprotkb:Kiaa0462(gene name synonym)|uniprotkb:Zubr1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Ubr4(gene name)|psi-mi:Ubr4(display_short)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:p600(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_001153791.1|dip:DIP-61499N|ensembl:ENSMUSG00000066036(gene)|ensembl:ENSMUST00000097822(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:A2AN08|reactome:R-MMU-6798695|reactome:R-MMU-983168|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:dTpQoZkH0+rwfrguOvzwrbPh0+Y10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q505D9	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-16730443|ensembl:ENSMUSP00000040601|ensembl:ENSMUSP00000130343|ensembl:ENSMUSP00000148625	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:tri67_mouse(display_long)|uniprotkb:Trim67(gene name)|psi-mi:Trim67(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000036913(gene)|ensembl:ENSMUST00000041106(transcript)|ensembl:ENSMUST00000167588(transcript)|ensembl:ENSMUST00000211867(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0005856"(cytoskeleton)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003649(B-box, C-terminal)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017903|interpro:IPR017907|interpro:IPR018957|interpro:IPR036116|interpro:IPR043136|refseq:NP_941034.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:+6C8z3p2A0XP3TDoSTLGQmF/gdM10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q8BXJ2	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-9673394|uniprotkb:Q32NY5|uniprotkb:Q6PCQ4|uniprotkb:Q80X25|uniprotkb:Q810H8|uniprotkb:Q8BY31	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:tref1_mouse(display_long)|uniprotkb:Trerf1(gene name)|psi-mi:Trerf1(display_short)|uniprotkb:Transcriptional-regulating protein 132(gene name synonym)|uniprotkb:Zinc finger transcription factor TReP-132(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	interpro:IPR000949(ELM2)|interpro:IPR009057(Homeodomain-like)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR017884|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|refseq:NP_001091092.1|refseq:NP_766210.1|interpro:IPR036236|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016575"(histone deacetylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0071393"(cellular response to progesterone stimulus)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:ZB8SY+WpE0Sd0HtmSRBY2uSBxoo10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:P70399	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-769130|uniprotkb:Q68FD0|uniprotkb:Q8CI97|uniprotkb:Q91YC9|intact:EBI-11051502|intact:EBI-11516626|uniprotkb:A2AU89|uniprotkb:A2AU91|ensembl:ENSMUSP00000106278	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:tp53b_mouse(display_long)|uniprotkb:Tp53bp1(gene name)|psi-mi:Tp53bp1(display_short)|uniprotkb:Trp53bp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_001277759.1|refseq:NP_038763.3|dip:DIP-31595N|refseq:XP_011237883.1|ensembl:ENSMUSG00000043909(gene)|ensembl:ENSMUST00000110648(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:P70399|rcsb pdb:1SSF|reactome:R-MMU-3232118|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:z5tOHbR6ApNZRL9aptim/xRaVo010090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q9JJ11	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-2553611|uniprotkb:Q9WVK9	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:tacc3_mouse(display_long)|uniprotkb:Tacc3(gene name)|psi-mi:Tacc3(display_short)|uniprotkb:Aint(gene name synonym)|uniprotkb:ARNT-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	interpro:IPR039915|rcsb pdb:4LPZ|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:1902850"(microtubule cytoskeleton organization involved in mitosis)|interpro:IPR007707(Transforming acidic coiled-coil-containing)|rcsb pdb:4PKY	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:sYeRunm6OTitr0yic6YvcNdqtRA10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q6ZWQ0	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-11517168|uniprotkb:Q640M5|ensembl:ENSMUSP00000047697	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:syne2_mouse(display_long)|uniprotkb:Nuclear envelope spectrin repeat protein 2(gene name synonym)|uniprotkb:Nucleus and actin connecting element protein(gene name synonym)|uniprotkb:Synaptic nuclear envelope protein 2(gene name synonym)|uniprotkb:KASH domain-containing protein 2(gene name synonym)|uniprotkb:Syne2(gene name)|psi-mi:Syne2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	dip:DIP-61049N|refseq:NP_001005510.2|ensembl:ENSMUSG00000063450(gene)|ensembl:ENSMUST00000044217(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0005739"(mitochondrion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031981"(nuclear lumen)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0007097"(nuclear migration)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051642"(centrosome localization)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR012315(Klarsicht/ANC-1/syne-1 homology)|interpro:IPR018159|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|interpro:IPR030266|interpro:IPR036872|mint:Q6ZWQ0	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:dByvgsaISSaQdpGCQahK7a5mG2w10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q91Z67	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-16730393|ensembl:ENSMUSP00000095195|uniprotkb:B2RY13|uniprotkb:Q3V1V8|uniprotkb:Q61054	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:srgp2_mouse(display_long)|uniprotkb:Formin-binding protein 2(gene name synonym)|uniprotkb:Formin-binding protein 27(gene name synonym)|uniprotkb:Srgap2(gene name)|psi-mi:Srgap2(display_short)|uniprotkb:Fbp27(gene name synonym)|uniprotkb:Fnbp2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000026425(gene)|ensembl:ENSMUST00000097588(transcript)|go:"GO:0003363"(lamellipodium assembly involved in ameboidal cell migration)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0021816"(extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044327"(dendritic spine head)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051014"(actin filament severing)|go:"GO:0060996"(dendritic spine development)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000198(RhoGAP)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267|interpro:IPR030252|interpro:IPR031160|interpro:IPR035648|interpro:IPR036028|mint:Q91Z67|reactome:R-MMU-5663220|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|refseq:NP_001074480.2|refseq:XP_006529197.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:MLCAa8wEQvKNPatehgSzcizs2YI10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q62261	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q62417	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-2365368|uniprotkb:Q80TF8|uniprotkb:Q8BZI3|uniprotkb:Q8K3Y2|uniprotkb:Q921F8|uniprotkb:Q9Z0Z8|uniprotkb:Q9Z0Z9	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:srbs1_mouse(display_long)|uniprotkb:Sorbs1(gene name)|psi-mi:Sorbs1(display_short)|uniprotkb:Kiaa1296(gene name synonym)|uniprotkb:Sh3d5(gene name synonym)|uniprotkb:Ponsin(gene name synonym)|uniprotkb:c-Cbl-associated protein(gene name synonym)|uniprotkb:SH3 domain protein 5(gene name synonym)|uniprotkb:SH3P12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_001030134.1|refseq:NP_001030135.1|refseq:NP_001030136.1|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|interpro:IPR035606|interpro:IPR035610|interpro:IPR035611|interpro:IPR036028|mint:Q62417|go:"GO:0001725"(stress fiber)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016600"(flotillin complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|reactome:R-MMU-445355	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:3+0ZfSkNB+9ujOF3uyXmP2ovl8A10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:P46062	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-16730373|uniprotkb:P70204	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:sipa1_mouse(display_long)|uniprotkb:GTPase-activating protein Spa-1(gene name synonym)|uniprotkb:Sipa1(gene name)|psi-mi:Sipa1(display_short)|uniprotkb:Spa-1(gene name synonym)|uniprotkb:Spa1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	reactome:R-MMU-392517|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR035974|interpro:IPR000331(Rap/ran-GAP)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:0Xo2HFTozq7tSRRov5+VuZskCpA10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q6NZC7	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-16730348|uniprotkb:Q8BXY6	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:s23ip_mouse(display_long)|uniprotkb:Sec23ip(gene name)|psi-mi:Sec23ip(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	reactome:R-MMU-204005|go:"GO:0001675"(acrosome assembly)|go:"GO:0004620"(phospholipase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR004177(DDHD)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:jWDkoDwfR19H5VAnGeT/9BDl0ZM10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q01405	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-775901|ensembl:ENSMUSP00000021375|uniprotkb:Q8JZL4	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:sc23a_mouse(display_long)|uniprotkb:SEC23-related protein A(gene name synonym)|uniprotkb:Sec23a(gene name)|psi-mi:Sec23a(display_short)|uniprotkb:Sec23(gene name synonym)|uniprotkb:Sec23r(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000020986(gene)|ensembl:ENSMUST00000021375(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR007123(Gelsolin region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|refseq:NP_033173.2|refseq:XP_006515691.1|dip:DIP-32032N|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR037364|interpro:IPR037550|mint:Q01405|reactome:R-MMU-204005|reactome:R-MMU-2132295|reactome:R-MMU-5694530|reactome:R-MMU-983170	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:0aSRfr1sJuL/w805EjjbO4tw/Hg10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:P62137	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-357187|ensembl:ENSMUSP00000039109|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:Q3U7G7|uniprotkb:Q9Z1G2	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:pp1a_mouse(display_long)|uniprotkb:Ppp1ca(gene name)|psi-mi:Ppp1ca(display_short)|uniprotkb:Ppp1a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62137|rcsb pdb:5ZQV|rcsb pdb:5ZT0|reactome:R-MMU-180024|ensembl:ENSMUSG00000040385(gene)|ensembl:ENSMUST00000046094(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|refseq:NP_114074.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:kr38FkfqhN5ex5rxh4ZJbSdd8IM10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:B2RXQ2	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-6271672|ensembl:ENSMUSP00000138312	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:b2rxq2_mouse(display_long)|uniprotkb:Ppfia1(gene name)|psi-mi:Ppfia1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000037519(gene)|ensembl:ENSMUST00000182226(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032991"(protein-containing complex)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050808"(synapse organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR029515|interpro:IPR030438|interpro:IPR037620|interpro:IPR037621|interpro:IPR037622|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-388844|refseq:NP_001182015.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:MQSrjjRGmJALqLEXJPLfa3CIZd010090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q9JMG9	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-647451|ensembl:ENSMUSP00000050684	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:q9jmg9_mouse(display_long)|uniprotkb:Patz1(gene name)|psi-mi:Patz1(display_short)|uniprotkb:mazr(gene name synonym)|uniprotkb:Zfp278(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_062520.1|ensembl:ENSMUSG00000020453(gene)|ensembl:ENSMUST00000057089(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:m7We0Bhp0gKP4tZJ+cLTOVGEoiI10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q5NCX5	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-4284398|uniprotkb:Q3U090|uniprotkb:Q5NCX4|uniprotkb:Q69ZA2|uniprotkb:Q8R1V5|ensembl:ENSMUSP00000053235	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:neul4_mouse(display_long)|uniprotkb:Neurl4(gene name)|psi-mi:Neurl4(display_short)|uniprotkb:Kiaa1787(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_001013432.1|refseq:NP_001278047.1|refseq:NP_001278048.1|ensembl:ENSMUSG00000047284(gene)|ensembl:ENSMUST00000061837(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR006573(NEUZ)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037962|interpro:IPR043136|mint:Q5NCX5|refseq:XP_017169947.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:ptQRCtQs60MpIBFD5++Vnv69Sfc10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q61879	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-400918|uniprotkb:Q5SV63|ensembl:ENSMUSP00000099671	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:myh10_mouse(display_long)|uniprotkb:Myh10(gene name)|psi-mi:Myh10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_780469.1|ensembl:ENSMUSG00000020900(gene)|ensembl:ENSMUST00000102611(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001764"(neuron migration)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0006887"(exocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007097"(nuclear migration)|go:"GO:0007155"(cell adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0021592"(fourth ventricle development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021678"(third ventricle development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035904"(aorta development)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0070650"(actin filament bundle distribution)|go:"GO:0097513"(myosin II filament)|dip:DIP-31956N|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q61879|reactome:R-MMU-5627123	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:DE0ILvXp+FsQ8J8yXJ38FaeQtzM10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:A2AJI0	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-2934973|ensembl:ENSMUSP00000054338|uniprotkb:Q80TI3|uniprotkb:Q8CIL3|uniprotkb:Q8VCG2|uniprotkb:Q91YQ4	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:ma7d1_mouse(display_long)|uniprotkb:Map7d1(gene name)|psi-mi:Map7d1(display_short)|uniprotkb:Kiaa1187(gene name synonym)|uniprotkb:Mtap7d1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000028849(gene)|ensembl:ENSMUST00000061143(transcript)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR008604(E-MAP-115)|mint:A2AJI0|go:"GO:0000226"(microtubule cytoskeleton organization)|refseq:NP_659190.3|refseq:XP_006503175.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:Boq4UxlYwW27VQuQlRb9XpySiu810090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:P25206	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-913666|uniprotkb:Q61492|ensembl:ENSMUSP00000059192	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:mcm3_mouse(display_long)|uniprotkb:Mcm3(gene name)|psi-mi:Mcm3(display_short)|uniprotkb:Mcmd(gene name synonym)|uniprotkb:Mcmd3(gene name synonym)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000041859(gene)|ensembl:ENSMUST00000053266(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25206|reactome:R-MMU-176187|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962|reactome:R-MMU-69052|refseq:NP_032589.1|dip:DIP-45878N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:X36cGhJW1lAq2x928zZS9WI2reE10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q8K310	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-1216295|ensembl:ENSMUSP00000125761|ensembl:ENSMUSP00000158074|ensembl:ENSMUSP00000158537	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:matr3_mouse(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_034901.2|rcsb pdb:1X4F|rcsb pdb:1X4D|ensembl:ENSMUSG00000037236(gene)|ensembl:ENSMUST00000166793(transcript)|ensembl:ENSMUST00000235199(transcript)|ensembl:ENSMUST00000237744(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:Q8K310	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:AwtFbI+oRfha+mn/v3yzG6bNXYg10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q7TSJ2	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-774081|uniprotkb:O55129|uniprotkb:O70586|uniprotkb:O70587|uniprotkb:Q78DV4|uniprotkb:Q78DV5|intact:EBI-911047|ensembl:ENSMUSP00000064787|ensembl:ENSMUSP00000146585	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:map6_mouse(display_long)|uniprotkb:Map6(gene name)|psi-mi:Map6(display_short)|uniprotkb:Mtap6(gene name synonym)|uniprotkb:Stable tubule-only polypeptide(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_001036820.2|refseq:NP_001041632.1|refseq:NP_034967.2|ensembl:ENSMUSG00000055407(gene)|ensembl:ENSMUST00000068973(transcript)|ensembl:ENSMUST00000207883(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032418"(lysosome localization)|go:"GO:0043005"(neuron projection)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0099503"(secretory vesicle)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR007882(STOP)|mint:Q7TSJ2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:NfrleOOHFaMul1xiYAgILTgLzWg10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q9QXZ0	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-643248|intact:EBI-2658096|uniprotkb:B1ARU3|uniprotkb:Q4PLL5|uniprotkb:P97394|uniprotkb:P97395|uniprotkb:P97396	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:macf1_mouse(display_long)|uniprotkb:Actin cross-linking family 7(gene name synonym)|uniprotkb:Macf1(gene name)|psi-mi:Macf1(display_short)|uniprotkb:Acf7(gene name synonym)|uniprotkb:Aclp7(gene name synonym)|uniprotkb:Macf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR002017(Spectrin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR001101(Plectin repeat)|interpro:IPR018159|interpro:IPR001452(Src homology-3)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0008104"(protein localization)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|mint:Q9QXZ0|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:niJxpkI45VTa5x73A1tuX/aLXgo10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:P28738	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-2506834|uniprotkb:Q6NXI9|ensembl:ENSMUSP00000028102|uniprotkb:Q9Z2F8	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:kif5c_mouse(display_long)|uniprotkb:Kif5c(gene name)|psi-mi:Kif5c(display_short)|uniprotkb:Nkhc2(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000026764(gene)|ensembl:ENSMUST00000028102(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051028"(mRNA transport)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098964"(anterograde dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0150034"(distal axon)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:P28738|rcsb pdb:1VFV|rcsb pdb:1VFW|rcsb pdb:1VFX|rcsb pdb:1VFZ|rcsb pdb:3J6H|rcsb pdb:3WRD|rcsb pdb:3X2T|rcsb pdb:5HLE|refseq:NP_032475.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:GbPyKDztqPG8BP2+44k3TXPuI/010090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q61768	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-776129|uniprotkb:Q5BL10|uniprotkb:O08711|uniprotkb:Q61580|ensembl:ENSMUSP00000025083	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:kinh_mouse(display_long)|uniprotkb:Ubiquitous kinesin heavy chain(gene name synonym)|uniprotkb:Conventional kinesin heavy chain(gene name synonym)|uniprotkb:Kif5b(gene name)|psi-mi:Kif5b(display_short)|uniprotkb:Khcs(gene name synonym)|uniprotkb:Kns1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_032474.2|dip:DIP-32053N|ensembl:ENSMUSG00000006740(gene)|ensembl:ENSMUST00000025083(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0021766"(hippocampus development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032418"(lysosome localization)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072383"(plus-end-directed vesicle transport along microtubule)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099609"(microtubule lateral binding)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905152"(positive regulation of voltage-gated sodium channel activity)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q61768|rcsb pdb:6IGN|rcsb pdb:6IGV|reactome:R-MMU-2132295|reactome:R-MMU-5625970|reactome:R-MMU-6811434|reactome:R-MMU-983189	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:11aePhwWZOqqAabjyanVgdHQQso10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q6P9P6	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-6908345|ensembl:ENSMUSP00000012587|uniprotkb:Q9Z1J0	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:kif11_mouse(display_long)|uniprotkb:Kif11(gene name)|psi-mi:Kif11(display_short)|uniprotkb:Kinesin-related motor protein Eg5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000012443(gene)|ensembl:ENSMUST00000012587(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007051"(spindle organization)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR025901|interpro:IPR027417|interpro:IPR036961|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189|refseq:NP_034745.1|dip:DIP-62086N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:UezMxfmkap8jUT2qwT32hICvI/E10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:P70288	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-302251|uniprotkb:B2RRP3	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:hdac2_mouse(display_long)|uniprotkb:Hdac2(gene name)|psi-mi:Hdac2(display_short)|uniprotkb:Yy1bp(gene name synonym)|uniprotkb:YY1 transcription factor-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-4551638|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-9022692|reactome:R-MMU-983231|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|refseq:NP_032255.2|dip:DIP-32854N|mint:P70288	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:bGLIDKTlyhBz40NViC8calRacZ010090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q6ZQ86	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-16730334	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:q6zq86_mouse(display_long)|uniprotkb:Hectd4(gene name)|psi-mi:Hectd4(display_short)|uniprotkb:AU042671(gene name synonym)|uniprotkb:Gm15800(gene name synonym)|uniprotkb:mKIAA0614(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0042593"(glucose homeostasis)|interpro:IPR000569(HECT)|interpro:IPR035983|interpro:IPR043366	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:dQn3lg/diLQSWmXSUH7yOUoAaJY10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:P10126	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-773865|uniprotkb:Q61511|uniprotkb:Q6ZWN2|uniprotkb:Q8BMB8|uniprotkb:Q8BVS8|uniprotkb:Q99KU5|ensembl:ENSMUSP00000042457	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:ef1a1_mouse(display_long)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Eef1a1(gene name)|psi-mi:Eef1a1(display_short)|uniprotkb:Eef1a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	dip:DIP-46609N|refseq:NP_034236.2|ensembl:ENSMUSG00000037742(gene)|ensembl:ENSMUST00000042235(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P10126|reactome:R-MMU-156842|reactome:R-MMU-3371511|reactome:R-MMU-6798695|reactome:R-MMU-8876725	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:85G9Uje743KzA02bB/rmKuq2HbU10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q91ZU6	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-446159|uniprotkb:Q60845|uniprotkb:Q9WU50|uniprotkb:Q1KP04|uniprotkb:Q3I6J6|uniprotkb:Q8K5D4|uniprotkb:Q91ZU7|uniprotkb:Q91ZU8|uniprotkb:Q60824|uniprotkb:E9PXE5|uniprotkb:E9QL23|uniprotkb:S4R1U5|ensembl:ENSMUSP00000095392	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:dyst_mouse(display_long)|uniprotkb:Dystonia musculorum protein(gene name synonym)|uniprotkb:Hemidesmosomal plaque protein(gene name synonym)|uniprotkb:Dst(gene name)|psi-mi:Dst(display_short)|uniprotkb:Bpag1(gene name synonym)|uniprotkb:Macf2(gene name synonym)|uniprotkb:Microtubule actin cross-linking factor 2(gene name synonym)|uniprotkb:Bullous pemphigoid antigen 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_034211.2|refseq:NP_598594.2|refseq:NP_604443.2|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031673"(H zone)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042060"(wound healing)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0046907"(intracellular transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR011992(EF-Hand type)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:Q91ZU6|rcsb pdb:2IAK|reactome:R-MMU-446107|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-9696264|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000026131(gene)|ensembl:ENSMUST00000097785(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014069"(postsynaptic density)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:kQkueAqyWyioKh0Hf1vVtIaHRY810090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:O08553	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-446064|uniprotkb:Q6P5D0|ensembl:ENSMUSP00000022629	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:dpyl2_mouse(display_long)|uniprotkb:Unc-33-like phosphoprotein 2(gene name synonym)|uniprotkb:Dpysl2(gene name)|psi-mi:Dpysl2(display_short)|uniprotkb:Crmp2(gene name synonym)|uniprotkb:Ulip2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_034085.2|ensembl:ENSMUSG00000022048(gene)|ensembl:ENSMUST00000022629(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043209"(myelin sheath)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098793"(presynapse)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030615|interpro:IPR032466|mint:O08553|rcsb pdb:5UQC|reactome:R-MMU-399956|reactome:R-MMU-437239	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:97yc8TNEPMcGtGNRLvl+KV+DYr010090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q8R1A4	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-776274|uniprotkb:Q45V78|uniprotkb:Q5PRE6|uniprotkb:Q6PJ17|uniprotkb:Q9CSB6|uniprotkb:Q9CXM7	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:dock7_mouse(display_long)|uniprotkb:Gm430(gene name synonym)|uniprotkb:Dock7(gene name)|psi-mi:Dock7(display_short)|uniprotkb:Kiaa1771(gene name synonym)|uniprotkb:Mnlt(gene name synonym)|uniprotkb:Protein moonlight(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	interpro:IPR027357|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR043162|interpro:IPR043161|interpro:IPR026791|interpro:IPR027007|interpro:IPR035892|interpro:IPR037808|mint:Q8R1A4|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043473"(pigmentation)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|reactome:R-MMU-8875555|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-983231	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:T4W30iJF8XaTuK57c9vlJFr9gpg10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q62167	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-773173|uniprotkb:O09060|uniprotkb:O09143|ensembl:ENSMUSP00000000804	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:ddx3x_mouse(display_long)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD3(gene name synonym)|uniprotkb:Embryonic RNA helicase(gene name synonym)|uniprotkb:D1Pas1-related sequence 2(gene name synonym)|uniprotkb:Ddx3x(gene name)|psi-mi:Ddx3x(display_short)|uniprotkb:D1Pas1-rs2(gene name synonym)|uniprotkb:Ddx3(gene name synonym)|uniprotkb:Dead3(gene name synonym)|uniprotkb:Erh(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_034158.1|ensembl:ENSMUSG00000000787(gene)|ensembl:ENSMUST00000000804(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q62167|reactome:R-MMU-6798695	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:K7PtRsPpXHni4TU8uzOsr6QaVxA10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q9QXS6	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-445208|uniprotkb:A2CG16|uniprotkb:Q3V234|uniprotkb:Q922X1|uniprotkb:Q9QXS5|ensembl:ENSMUSP00000021950	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:dreb_mouse(display_long)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:Dbn1(gene name)|psi-mi:Dbn1(display_short)|uniprotkb:Drba(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_001170842.1|refseq:NP_001170843.1|refseq:NP_062787.2|ensembl:ENSMUSG00000034675(gene)|ensembl:ENSMUST00000021950(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0005856"(cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048699"(generation of neurons)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0098828"(modulation of inhibitory postsynaptic potential)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:1904113"(negative regulation of muscle filament sliding)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q9QXS6|reactome:R-MMU-9013405|reactome:R-MMU-9013407|reactome:R-MMU-9013418|reactome:R-MMU-9013422	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:ArZUGZNIUfSwoIketPcPCXlSM8410090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:P53564	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-642309|uniprotkb:O08994|uniprotkb:P70301|uniprotkb:Q571L6|uniprotkb:Q91ZD2	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:cux1_mouse(display_long)|uniprotkb:CCAAT displacement protein(gene name synonym)|uniprotkb:Homeobox protein cux-1(gene name synonym)|uniprotkb:Kiaa4047(gene name synonym)|uniprotkb:Cux1(gene name)|psi-mi:Cux1(display_short)|uniprotkb:Cux(gene name synonym)|uniprotkb:Cutl1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	interpro:IPR003350(Homeodomain protein CUT)|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|mint:P53564|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030324"(lung development)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0043005"(neuron projection)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|refseq:NP_001278162.1|refseq:NP_001278163.1|refseq:NP_034116.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:XozohEVVgGk0JJ5Qaw2AmPO+dHI10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q6ZQ08	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-682479|intact:EBI-2104684|uniprotkb:B2RY28|uniprotkb:Q3UPB7|uniprotkb:Q8BSB4|uniprotkb:Q8BXB2|uniprotkb:Q8C0H2|uniprotkb:Q8K3D8	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:cnot1_mouse(display_long)|uniprotkb:Cnot1(gene name)|psi-mi:Cnot1(display_short)|uniprotkb:Kiaa1007(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_835179.1|refseq:XP_006530937.1|dip:DIP-46845N|mint:Q6ZQ08|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|reactome:R-MMU-429947|reactome:R-MMU-6804115	-	-	comment:AfCS Y2H protein 39306. Translated from nucleotide sequence.	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:2Q4quoSuPlUbD4QkiAkc9Hr9avI10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q6A065	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-2554140|uniprotkb:Q7TQD9|uniprotkb:Q8BJW2|uniprotkb:Q9D3Z0|ensembl:ENSMUSP00000141793	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:ce170_mouse(display_long)|uniprotkb:Kiaa0470(gene name synonym)|uniprotkb:Cep170(gene name)|psi-mi:Cep170(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	ensembl:ENSMUSG00000057335(gene)|ensembl:ENSMUST00000194727(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q6A065|refseq:XP_006497000.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:gawEp+b6DVpUroRU0JHmHzo7qPg10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q9WVG6	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-4414343|uniprotkb:Q3TYB9|uniprotkb:Q8K1Y5|uniprotkb:Q91W24|uniprotkb:Q99KX8|ensembl:ENSMUSP00000034703	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:carm1_mouse(display_long)|uniprotkb:Carm1(gene name)|psi-mi:Carm1(display_short)|uniprotkb:Prmt4(gene name synonym)|uniprotkb:Coactivator-associated arginine methyltransferase 1(gene name synonym)|uniprotkb:Protein arginine N-methyltransferase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_067506.2|refseq:NP_694781.1|dip:DIP-44593N|ensembl:ENSMUSG00000032185(gene)|ensembl:ENSMUST00000034703(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006479"(protein methylation)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034969"(histone arginine methylation)|go:"GO:0034970"(histone H3-R2 methylation)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902415"(regulation of mRNA binding)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020989|interpro:IPR025799|interpro:IPR029063|mint:Q9WVG6|rcsb pdb:2V74|rcsb pdb:2V7E|rcsb pdb:5IH3|rcsb pdb:5IS6|rcsb pdb:5IS7|rcsb pdb:5IS8|rcsb pdb:5IS9|rcsb pdb:5ISA|rcsb pdb:5ISB|rcsb pdb:5ISC|rcsb pdb:5ISD|rcsb pdb:5ISE|rcsb pdb:5ISF|rcsb pdb:5ISG|rcsb pdb:5ISH|rcsb pdb:5ISI|rcsb pdb:5K8V|rcsb pdb:5K8W|rcsb pdb:5K8X|rcsb pdb:5LGP|rcsb pdb:5LGQ|rcsb pdb:5LGR|rcsb pdb:5LGS|rcsb pdb:5LKJ|rcsb pdb:5LV2|rcsb pdb:5LV3|rcsb pdb:5NTC|rcsb pdb:5TBH|rcsb pdb:5TBI|rcsb pdb:5TBJ|reactome:R-MMU-3214858|reactome:R-MMU-400206|reactome:R-MMU-9018519|reactome:R-MMU-9707564|go:"GO:0035642"("histone methyltransferase activity (H3-R17 specific)")	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:OhPIJ/O/PCm8s8oJoebgdYV133s10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:P59999	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-445034|uniprotkb:O15509|uniprotkb:Q3UWV4|ensembl:ENSMUSP00000114839	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:arpc4_mouse(display_long)|uniprotkb:Arp2/3 complex 20 kDa subunit(gene name synonym)|uniprotkb:Arpc4(gene name)|psi-mi:Arpc4(display_short)|uniprotkb:Arc20(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_001163956.1|refseq:NP_001163957.1|refseq:NP_080828.1|ensembl:ENSMUSG00000079426(gene)|ensembl:ENSMUST00000156898(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0051015"(actin filament binding)|interpro:IPR008384(ARP23 complex 20 kDa subunit)|interpro:IPR034666|mint:P59999|rcsb pdb:7AQK|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-5663213|reactome:R-MMU-8856828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:Iqe60TWfO3QBVOY+fOqZd9JWfIE10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q8C8R3	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-774322|intact:EBI-2133064|uniprotkb:Q6PCN2|uniprotkb:Q3TM62|uniprotkb:Q3V2X0|uniprotkb:Q80ZZ7|uniprotkb:Q8BNC1|uniprotkb:Q8C445|uniprotkb:Q8CCV0|intact:EBI-2255612|intact:EBI-8314005|intact:MINT-4115219	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:ank2_mouse(display_long)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:AnkB(gene name synonym)|uniprotkb:Ank2(gene name)|psi-mi:Ank2(display_short)|uniprotkb:Ankyrin-B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_001029340.1|refseq:NP_848770.2|dip:DIP-58645N|mint:Q8C8R3|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001257"(regulation of cation channel activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:SkB13oxZVcKuMnI8r5ItFIq2pXQ10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:Q70FJ1	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-645887|uniprotkb:Q3TH74|uniprotkb:Q80TR6	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:akap9_mouse(display_long)|uniprotkb:Akap9(gene name)|psi-mi:Akap9(display_short)|uniprotkb:Kiaa0803(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_919444.2|interpro:IPR019528|interpro:IPR028745|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007165"(signal transduction)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034705"(potassium channel complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044307"(dendritic branch)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097729"(9+2 motile cilium)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0120219"(subapical part of cell)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903358"(regulation of Golgi organization)|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5576890|reactome:R-MMU-5576893|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:Q70FJ1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:9yyCeoX35wNULJg413iGM9TIQxA10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4U2R1	uniprotkb:P63101	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730475|imex:IM-26285-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	rigid:DzMfQ51HEfoaptwPPzmu5ge84HM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P83510	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	-	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q00PI9	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-8586171|ensembl:ENSMUSP00000094515|uniprotkb:F8VPM4|intact:UNK-5385063	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:hnrl2_mouse(display_long)|uniprotkb:Manp(gene name synonym)|uniprotkb:Hnrpul2(gene name synonym)|uniprotkb:MLF1-associated nuclear protein(gene name synonym)|uniprotkb:Hnrnpul2(gene name)|psi-mi:Hnrnpul2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	ensembl:ENSMUSG00000071659(gene)|ensembl:ENSMUST00000096753(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|refseq:NP_001074665.1	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:oPTke2/M1XC8ou8Lcc4UY4Qz8sw10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q8R4H2	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-8046267|intact:MINT-1774761|uniprotkb:E9QPW9|uniprotkb:Q80U18|ensembl:ENSMUSP00000072547	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:arhgc_mouse(display_long)|uniprotkb:Arhgef12(gene name)|psi-mi:Arhgef12(display_short)|uniprotkb:Kiaa0382(gene name synonym)|uniprotkb:Larg(gene name synonym)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:XP_006510649.1|ensembl:ENSMUSG00000059495(gene)|ensembl:ENSMUST00000072767(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|mint:Q8R4H2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148	-	-	comment:mint|function:"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:5ZclDYjaUBilqiB548/6M5KlhVg10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:O88196	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-310028|uniprotkb:Q05D15|uniprotkb:Q3TMM9|uniprotkb:Q3TPC8|uniprotkb:Q3TPV5|uniprotkb:Q3TQL0|uniprotkb:Q3TSK0|uniprotkb:Q3UFH5|uniprotkb:Q5DTM5|uniprotkb:Q6PG61|uniprotkb:Q8BPM4|uniprotkb:Q8C2N6	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:ttc3_mouse(display_long)|uniprotkb:Ttc3(gene name)|psi-mi:Ttc3(display_short)|uniprotkb:Kiaa4119(gene name synonym)|uniprotkb:TPR repeat protein D(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TTC3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010771"(negative regulation of cell morphogenesis involved in differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR011029(DEATH-like)|interpro:IPR043866	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:c0v6smzObgNddoQsFT81OB1Fe6Q10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q6P5H2	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-2899462|ensembl:ENSMUSP00000088493|uniprotkb:A1E2I2|uniprotkb:Q80X00|uniprotkb:Q8BPH7|uniprotkb:Q9CV43|uniprotkb:Q9R0C4	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:nest_mouse(display_long)|uniprotkb:Nes(gene name)|psi-mi:Nes(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	ensembl:ENSMUST00000090973(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030844"(positive regulation of intermediate filament depolymerization)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048858"(cell projection morphogenesis)|ensembl:ENSMUSG00000004891(gene)|go:"GO:0072089"(stem cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR018039|interpro:IPR031211|interpro:IPR039008|refseq:NP_057910.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:c9UQwTSScUEP6n41WzoQiEzEyN410090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P58252	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-773856|uniprotkb:Q544E4|ensembl:ENSMUSP00000046101	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:ef2_mouse(display_long)|uniprotkb:Eef2(gene name)|psi-mi:Eef2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_031933.1|ensembl:ENSMUSG00000034994(gene)|ensembl:ENSMUST00000047864(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P58252|reactome:R-MMU-156902|reactome:R-MMU-5358493|reactome:R-MMU-6798695	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:910/vo3IRjcncyPD4f43dPtS83o10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P23475	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-822760|uniprotkb:Q3UJL8|uniprotkb:Q6GTV8|uniprotkb:Q8QZX7|uniprotkb:O88212|uniprotkb:Q62027|uniprotkb:Q62382|uniprotkb:Q62453	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:xrcc6_mouse(display_long)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Ku autoantigen protein p70 homolog(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:Xrcc6(gene name)|psi-mi:Xrcc6(display_short)|uniprotkb:G22p1(gene name synonym)|uniprotkb:Ku70(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	mint:P23475|refseq:NP_034377.2|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|refseq:XP_006520505.1|refseq:XP_006520506.1|refseq:XP_011243758.1|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|go:"GO:0000723"(telomere maintenance)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|reactome:R-MMU-5693571|reactome:R-MMU-6798695	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:/A6ygYkLE2FpziX/3fMu5IvG0iI10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P27641	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-822749|intact:EBI-1216334|uniprotkb:Q3TE46|uniprotkb:Q3TJT0|uniprotkb:Q3TN82|uniprotkb:Q80UT1|uniprotkb:Q8C4N6|uniprotkb:Q8K1K7|uniprotkb:Q9R169|ensembl:ENSMUSP00000027379	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:xrcc5_mouse(display_long)|uniprotkb:Xrcc5(gene name)|psi-mi:Xrcc5(display_short)|uniprotkb:G22p2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Ku autoantigen protein p86 homolog(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_033559.2|ensembl:ENSMUSG00000026187(gene)|ensembl:ENSMUST00000027379(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P27641|reactome:R-MMU-5693571|reactome:R-MMU-6798695	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:481Y2f/7RfAolsvjFd4PhQpJD9810090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q7TMQ7	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-16730917|ensembl:ENSMUSP00000079974|uniprotkb:Q80XN1	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:wdr91_mouse(display_long)|uniprotkb:Wdr91(gene name)|psi-mi:Wdr91(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	ensembl:ENSMUSG00000058486(gene)|ensembl:ENSMUST00000081214(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:1903362"(regulation of cellular protein catabolic process)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR039724|reactome:R-MMU-9013148|refseq:NP_001013384.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:yeP8GjED4WGiHixZP1TwF9mm0lc10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q5ND34	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-16730878|ensembl:ENSMUSP00000134266|uniprotkb:G5E8V0|uniprotkb:Q3TA90|uniprotkb:Q3TUS9|uniprotkb:Q6KAR1	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:wdr81_mouse(display_long)|uniprotkb:Wdr81(gene name)|psi-mi:Wdr81(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	ensembl:ENSMUSG00000045374(gene)|ensembl:ENSMUST00000173320(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0035973"(aggrephagy)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0050821"(protein stabilization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036372|reactome:R-MMU-9013148|interpro:IPR036322|refseq:NP_620400.2|refseq:XP_006532611.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:jM2b1xUZ0JEL8akk4fxTLVE7Jyg10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q9R1R2	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-775991|uniprotkb:Q3UMU5|ensembl:ENSMUSP00000053384|ensembl:ENSMUSP00000102401|ensembl:ENSMUSP00000114822	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:trim3_mouse(display_long)|uniprotkb:RING finger protein 22(gene name synonym)|uniprotkb:RING finger protein HAC1(gene name synonym)|uniprotkb:Trim3(gene name)|psi-mi:Trim3(display_short)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Rnf22(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_001272799.1|refseq:NP_001272800.1|refseq:NP_001272802.1|refseq:NP_061368.1|ensembl:ENSMUSG00000036989(gene)|ensembl:ENSMUST00000057525(transcript)|ensembl:ENSMUST00000106789(transcript)|ensembl:ENSMUST00000147044(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001258(NHL repeat)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR017907|interpro:IPR027370|mint:Q9R1R2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:fOQH1BPgmOXrJXOb8VYYFpNX0UQ10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P70399	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-769130|uniprotkb:Q68FD0|uniprotkb:Q8CI97|uniprotkb:Q91YC9|intact:EBI-11051502|intact:EBI-11516626|uniprotkb:A2AU89|uniprotkb:A2AU91|ensembl:ENSMUSP00000106278	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:tp53b_mouse(display_long)|uniprotkb:Tp53bp1(gene name)|psi-mi:Tp53bp1(display_short)|uniprotkb:Trp53bp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_001277759.1|refseq:NP_038763.3|dip:DIP-31595N|refseq:XP_011237883.1|ensembl:ENSMUSG00000043909(gene)|ensembl:ENSMUST00000110648(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:P70399|rcsb pdb:1SSF|reactome:R-MMU-3232118|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:z5tOHbR6ApNZRL9aptim/xRaVo010090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q8BYI9	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-774167|uniprotkb:A2RT70|uniprotkb:O88717|ensembl:ENSMUSP00000107298|ensembl:ENSMUSP00000141553	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:tenr_mouse(display_long)|uniprotkb:Restrictin(gene name synonym)|uniprotkb:Janusin(gene name synonym)|uniprotkb:Neural recognition molecule J1-160/180(gene name synonym)|uniprotkb:Tnr(gene name)|psi-mi:Tnr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_071707.2|refseq:XP_006496805.1|refseq:XP_006496806.1|refseq:XP_006496807.1|ensembl:ENSMUSG00000015829(gene)|ensembl:ENSMUST00000111669(transcript)|ensembl:ENSMUST00000192069(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0045121"(membrane raft)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048692"(negative regulation of axon extension involved in regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072534"(perineuronal net)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098966"(perisynaptic extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR033079|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:Q8BYI9|reactome:R-MMU-3000178	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:K7s7yPGS4RvIe+thCkAZIFGjNRA10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q62261	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q6NZL0	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-776265|uniprotkb:Q8BLM2|uniprotkb:Q9CSN3|uniprotkb:Q9CU45|ensembl:ENSMUSP00000090293	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:soga3_mouse(display_long)|uniprotkb:Soga3(gene name)|psi-mi:Soga3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_080414.2|ensembl:ENSMUSG00000038916(gene)|ensembl:ENSMUST00000092629(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|interpro:IPR027881	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:fqFLavYLqmaqDCGT+/GaB6l9h9U10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P62983	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-4282373|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:P49664|uniprotkb:P62991|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D2W3|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|ensembl:ENSMUSP00000099908|ensembl:ENSMUSP00000099909	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:rs27a_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Ubiquitin carboxyl extension protein 80(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-5689901|reactome:R-MMU-5693565|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696397|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6783310|reactome:R-MMU-6791226|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-6804760|reactome:R-MMU-6807004|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-5689877|reactome:R-MMU-69231|reactome:R-MMU-69481|reactome:R-MMU-69541|reactome:R-MMU-69601|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-75815|reactome:R-MMU-8849469|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8863795|reactome:R-MMU-8866652|reactome:R-MMU-8866654|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-901032|reactome:R-MMU-9010553|reactome:R-MMU-9013507|reactome:R-MMU-9020702|reactome:R-MMU-9033241|reactome:R-MMU-912631|reactome:R-MMU-917729|reactome:R-MMU-917937|reactome:R-MMU-936440|reactome:R-MMU-936964|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-8932339|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-9648002|reactome:R-MMU-9664873|reactome:R-MMU-9705462|reactome:R-MMU-9706369|reactome:R-MMU-9708530|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975956|reactome:R-MMU-975957|reactome:R-MMU-983168|reactome:R-MMU-9646399|ensembl:ENSMUSG00000020460(gene)|ensembl:ENSMUST00000102844(transcript)|ensembl:ENSMUST00000102845(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0046872"(metal ion binding)|reactome:R-MMU-110320|interpro:IPR000626(Ubiquitin)|interpro:IPR002906(Ribosomal protein S27a)|interpro:IPR011332(Ribosomal protein, zinc-binding)|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1253288|reactome:R-MMU-1295596|reactome:R-MMU-1358803|reactome:R-MMU-156827|reactome:R-MMU-168638|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|reactome:R-MMU-174048|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-179409|reactome:R-MMU-1799339|reactome:R-MMU-182971|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-201681|reactome:R-MMU-202424|reactome:R-MMU-205043|interpro:IPR038582|rcsb pdb:5GVI|reactome:R-MMU-209543|rcsb pdb:5XIS|rcsb pdb:5XIT|rcsb pdb:5XIU|reactome:R-MMU-209560|reactome:R-MMU-110312|reactome:R-MMU-110314|reactome:R-MMU-2173788|reactome:R-MMU-2173791|reactome:R-MMU-2173795|reactome:R-MMU-2173796|reactome:R-MMU-2467813|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2565942|reactome:R-MMU-2672351|reactome:R-MMU-2871837|reactome:R-MMU-3134975|reactome:R-MMU-349425|reactome:R-MMU-3769402|reactome:R-MMU-382556|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-2122948|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-4641263|reactome:R-MMU-532668|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5655862|reactome:R-MMU-5656121|reactome:R-MMU-5656169|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5675221|reactome:R-MMU-5675482|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-5685942|reactome:R-MMU-5687128|reactome:R-MMU-5689603|refseq:NP_001029037.1|refseq:NP_077239.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:AkJxTgRFL5RT5jWk5i3y4zX5tfA10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P42669	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-773823|ensembl:ENSMUSP00000059404	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:pura_mouse(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:Pura(gene name)|psi-mi:Pura(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_033015.1|refseq:XP_006525787.1|refseq:XP_011245162.1|ensembl:ENSMUSG00000043991(gene)|ensembl:ENSMUST00000051301(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:P42669	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:3LVZ5qdZYeJyeUVPhy3cozxROWs10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P63318	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-397096|uniprotkb:P05697|ensembl:ENSMUSP00000097874	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:kpcg_mouse(display_long)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_035232.1|ensembl:ENSMUSG00000078816(gene)|ensembl:ENSMUST00000100301(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0005829"(cytosol)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|interpro:IPR020454|interpro:IPR035892|mint:P63318|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-416993|reactome:R-MMU-5099900|reactome:R-MMU-76005	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:O89084	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-16727353|ensembl:ENSMUSP00000037025|uniprotkb:Q8R078|uniprotkb:Q9JHQ4|uniprotkb:Q9QX48|uniprotkb:Q9QX49|uniprotkb:Q9QXI8	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:pde4a_mouse(display_long)|uniprotkb:Pde4a(gene name)|psi-mi:Pde4a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	ensembl:ENSMUSG00000032177(gene)|ensembl:ENSMUST00000039413(transcript)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006198"(cAMP catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0030552"(cAMP binding)|go:"GO:0035690"|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR036971|interpro:IPR040844|reactome:R-MMU-180024|reactome:R-MMU-418555|refseq:NP_062772.3|refseq:NP_899668.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:VqmB1Wv+lB9Tu1P9f8jeMh7yRp810090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q8CIV2	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-16730855|ensembl:ENSMUSP00000056792|uniprotkb:Q68EE1|uniprotkb:Q6KAN7|uniprotkb:Q7TS84|uniprotkb:Q8CIV1|uniprotkb:Q99K29	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:mbrl_mouse(display_long)|uniprotkb:Transmembrane protein 259(gene name synonym)|uniprotkb:Tmem259(gene name)|psi-mi:Tmem259(display_short)|uniprotkb:ORF61(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	ensembl:ENSMUSG00000013858(gene)|ensembl:ENSMUST00000052885(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904294"(positive regulation of ERAD pathway)|interpro:IPR019144|refseq:NP_001003949.2|refseq:XP_006513553.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:Ci8nqBBPJtjy+h+eBrCniHF0ZsA10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q8CGY8	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-928496|uniprotkb:A2ALY1|uniprotkb:Q6PG10|uniprotkb:Q8BXH6|uniprotkb:Q91Y38|ensembl:ENSMUSP00000045409	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:ogt1_mouse(display_long)|uniprotkb:Ogt(gene name)|psi-mi:Ogt(display_short)|uniprotkb:O-linked N-acetylglucosamine transferase 110 kDa subunit(gene name synonym)|uniprotkb:O-GlcNAc transferase subunit p110(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:XP_006527799.1|refseq:NP_631883.2|refseq:NP_001277464.1|refseq:XP_011245805.1|dip:DIP-35700N|ensembl:ENSMUSG00000034160(gene)|ensembl:ENSMUST00000044475(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000791"(euchromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003824"(catalytic activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006041"(glucosamine metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0016262"(protein N-acetylglucosaminyltransferase activity)|go:"GO:0016485"(protein processing)|go:"GO:0017122"(protein N-acetylglucosaminyltransferase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0042277"(peptide binding)|go:"GO:0042588"(zymogen granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|go:"GO:0097363"(protein O-GlcNAc transferase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900038"(negative regulation of cellular response to hypoxia)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR029489|interpro:IPR037919|mint:Q8CGY8|reactome:R-MMU-3214847|reactome:R-MMU-5675482|reactome:R-MMU-5689603	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:5N8o2WxL0V7gh1ZEa3l30GbrZa810090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P46460	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-398006|uniprotkb:A2A646|uniprotkb:Q8BQ65|uniprotkb:Q8C3R2|uniprotkb:Q8CCT9|uniprotkb:Q8CEF0|uniprotkb:Q923C6|ensembl:ENSMUSP00000099364	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:nsf_mouse(display_long)|uniprotkb:Nsf(gene name)|psi-mi:Nsf(display_short)|uniprotkb:Skd2(gene name synonym)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 2"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_032766.2|ensembl:ENSMUSG00000034187(gene)|ensembl:ENSMUST00000103075(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46460|reactome:R-MMU-204005|reactome:R-MMU-416993|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811438|reactome:R-MMU-6811440	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:mqNfvBVWEdD4caFZug82c88vwE410090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P97300	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-774154|uniprotkb:Q3U519|uniprotkb:Q8C637|uniprotkb:Q8C6H8|ensembl:ENSMUSP00000135199	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:nptn_mouse(display_long)|uniprotkb:Stromal cell-derived receptor 1(gene name synonym)|uniprotkb:Nptn(gene name)|psi-mi:Nptn(display_short)|uniprotkb:Sdfr1(gene name synonym)|uniprotkb:Sdr1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_001280602.1|refseq:NP_033171.2|refseq:XP_006510945.1|refseq:XP_006510946.1|ensembl:ENSMUSG00000032336(gene)|ensembl:ENSMUST00000177292(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007411"(axon guidance)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902683"(regulation of receptor localization to synapse)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904861"(excitatory synapse assembly)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR027112|interpro:IPR036179|interpro:IPR043204|mint:P97300|go:"GO:0044325"(transmembrane transporter binding)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:t0jdeaic1GtKiVLSbZatothsVQg10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q9Z0J4	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-397596|uniprotkb:Q64208|uniprotkb:Q3UR10|ensembl:ENSMUSP00000120421|ensembl:ENSMUSP00000127432	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:nos1_mouse(display_long)|uniprotkb:Nos1(gene name)|psi-mi:Nos1(display_short)|uniprotkb:bNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_032738.1|refseq:XP_017176196.1|dip:DIP-31556N|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099163"(synaptic signaling by nitric oxide)|go:"GO:0140196"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:0070402"(NADPH binding)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042582"(azurophil granule)|go:"GO:0042738"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044305"(calyx of Held)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0061875"(negative regulation of hepatic stellate cell contraction)|go:"GO:0032991"(protein-containing complex)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR001094(Flavodoxin-like)|interpro:IPR039261|rcsb pdb:2O60|reactome:R-MMU-1222556|reactome:R-MMU-392154|reactome:R-MMU-5578775|ensembl:ENSMUSG00000029361(gene)|ensembl:ENSMUST00000142742(transcript)|ensembl:ENSMUST00000171055(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030141"(secretory granule)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:BuPBvQk0jEhDNZNi82D3OidmYwE10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P28738	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-2506834|uniprotkb:Q6NXI9|ensembl:ENSMUSP00000028102|uniprotkb:Q9Z2F8	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:kif5c_mouse(display_long)|uniprotkb:Kif5c(gene name)|psi-mi:Kif5c(display_short)|uniprotkb:Nkhc2(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	ensembl:ENSMUSG00000026764(gene)|ensembl:ENSMUST00000028102(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051028"(mRNA transport)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098964"(anterograde dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0150034"(distal axon)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:P28738|rcsb pdb:1VFV|rcsb pdb:1VFW|rcsb pdb:1VFX|rcsb pdb:1VFZ|rcsb pdb:3J6H|rcsb pdb:3WRD|rcsb pdb:3X2T|rcsb pdb:5HLE|refseq:NP_032475.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:GbPyKDztqPG8BP2+44k3TXPuI/010090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q9QXL2	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-911098|uniprotkb:Q6P5H1|uniprotkb:Q6ZPJ8|uniprotkb:Q8BWZ9|uniprotkb:Q8BXF1|ensembl:ENSMUSP00000085985	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:ki21a_mouse(display_long)|uniprotkb:Kif21a(gene name)|psi-mi:Kif21a(display_short)|uniprotkb:Kiaa1708(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_001102510.1|refseq:NP_001102511.1|refseq:NP_001102512.1|refseq:NP_057914.2|ensembl:ENSMUSG00000022629(gene)|ensembl:ENSMUST00000088614(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:1990939"|interpro:IPR001680(WD40 repeat)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036322|interpro:IPR036961|mint:Q9QXL2|rcsb pdb:5YAY|rcsb pdb:5YBE|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:PQNGrSKw7f5ThMhMs/glF32RiZs10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q5SZV5	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-16730828|ensembl:ENSMUSP00000006893|uniprotkb:Q14BF3|uniprotkb:Q80U39	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:k0319_mouse(display_long)|uniprotkb:Kiaa0319(gene name)|psi-mi:Kiaa0319(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	ensembl:ENSMUSG00000006711(gene)|ensembl:ENSMUST00000006893(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048692"(negative regulation of axon extension involved in regeneration)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR000601(PKD)|interpro:IPR011106(Seven cysteines, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013980(Seven cysteines)|interpro:IPR022409|interpro:IPR029865|interpro:IPR035986|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_001074520.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:ZpraDZ5/wzh2uwo5RFKXjUBrDYs10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q8BX02	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-4286428|uniprotkb:Q91Z35|uniprotkb:Q8BLD5|ensembl:ENSMUSP00000034717	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:kank2_mouse(display_long)|uniprotkb:Kank2(gene name)|psi-mi:Kank2(display_short)|uniprotkb:Ankrd25(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 25(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_663586.3|ensembl:ENSMUSG00000032194(gene)|ensembl:ENSMUST00000034717(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070563"(negative regulation of vitamin D receptor signaling pathway)|go:"GO:0072073"(kidney epithelium development)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR021939|interpro:IPR036770|mint:Q8BX02	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:3gK/EE6Zo5R23a10e9dnUUf2sM410090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q8BUK6	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-1777179|uniprotkb:Q8BV48|uniprotkb:Q8BW57|uniprotkb:Q8BY41|uniprotkb:Q540A0|ensembl:ENSMUSP00000046788	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:hook3_mouse(display_long)|uniprotkb:Hook3(gene name)|psi-mi:Hook3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_997542.1|ensembl:ENSMUSG00000037234(gene)|ensembl:ENSMUST00000037182(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0030897"(HOPS complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|mint:Q8BUK6	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:PUiCL1lU5asAM+rngKPeVDsgomE10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P15105	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-444858|uniprotkb:Q3TRK7|uniprotkb:Q64432|uniprotkb:Q91VC6|ensembl:ENSMUSP00000083375|ensembl:ENSMUSP00000123157	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:glna_mouse(display_long)|uniprotkb:Glutamate--ammonia ligase(gene name synonym)|uniprotkb:Glul(gene name)|psi-mi:Glul(display_short)|uniprotkb:Glns(gene name synonym)|uniprotkb:Palmitoyltransferase GLUL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_032157.2|go:"GO:0030145"(manganese ion binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0097386"(glial cell projection)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR008146(Glutamine synthetase, catalytic region)|interpro:IPR008147(Glutamine synthetase, beta-Grasp)|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR027302|interpro:IPR027303|interpro:IPR036651|mint:P15105|reactome:R-MMU-210455|reactome:R-MMU-8964539|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|ensembl:ENSMUSG00000026473(gene)|ensembl:ENSMUST00000086199(transcript)|ensembl:ENSMUST00000140685(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0004356"(glutamate-ammonia ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006542"(glutamine biosynthetic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0016595"(glutamate binding)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019676"(ammonia assimilation cycle)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:j6R9fxGLKpiREWpecpdnBY9ftoo10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q68FF6	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-645933|ensembl:ENSMUSP00000037210	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:A2A699	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-16726238|ensembl:ENSMUSP00000038486|uniprotkb:B7ZC48|uniprotkb:Q05CH6|uniprotkb:Q6P2L1	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:f1712_mouse(display_long)|uniprotkb:Fam171a2(gene name)|psi-mi:Fam171a2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	ensembl:ENSMUSG00000034685(gene)|ensembl:ENSMUST00000049057(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR018890|refseq:NP_954670.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:7NVAzhDbIF2fudv/6EvN9nU/Ops10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q99MI1	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-774429|uniprotkb:Q80TK7|uniprotkb:Q8BPL1|uniprotkb:Q8C7Y1|uniprotkb:Q99MI2	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:rb6i2_mouse(display_long)|uniprotkb:Rab6-interacting protein 2(gene name synonym)|uniprotkb:CAZ-associated structural protein 2(gene name synonym)|uniprotkb:Erc1(gene name)|psi-mi:Erc1(display_short)|uniprotkb:Cast2(gene name synonym)|uniprotkb:Rab6ip2(gene name synonym)|uniprotkb:Kiaa1081(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	interpro:IPR037245|refseq:NP_835186.1|interpro:IPR019323|interpro:IPR019018|mint:Q99MI1|go:"GO:0000139"(Golgi membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045202"(synapse)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048790"(maintenance of presynaptic active zone structure)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:AyNtRSrffpmx4M5j9j+BH3cGBvA10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q9WV92	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-911885|uniprotkb:Q69ZT8|ensembl:ENSMUSP00000079098|uniprotkb:Q9R102	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:e41l3_mouse(display_long)|uniprotkb:4.1B(gene name synonym)|uniprotkb:Differentially expressed in adenocarcinoma of the lung protein 1(gene name synonym)|uniprotkb:Epb41l3(gene name)|psi-mi:Epb41l3(display_short)|uniprotkb:Dal1(gene name synonym)|uniprotkb:Epb4.1l3(gene name synonym)|uniprotkb:Kiaa0987(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	ensembl:ENSMUSG00000024044(gene)|ensembl:ENSMUST00000080208(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043217"(myelin maintenance)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030691|interpro:IPR035963|mint:Q9WV92|reactome:R-MMU-6794361|refseq:NP_038841.1|refseq:XP_011244586.1|refseq:XP_011244591.1|refseq:XP_017172724.1|refseq:XP_017172725.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:51gkxiswTUqQbAUqjGoPthWD7jM10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:O08553	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-446064|uniprotkb:Q6P5D0|ensembl:ENSMUSP00000022629	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:dpyl2_mouse(display_long)|uniprotkb:Unc-33-like phosphoprotein 2(gene name synonym)|uniprotkb:Dpysl2(gene name)|psi-mi:Dpysl2(display_short)|uniprotkb:Crmp2(gene name synonym)|uniprotkb:Ulip2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_034085.2|ensembl:ENSMUSG00000022048(gene)|ensembl:ENSMUST00000022629(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043209"(myelin sheath)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098793"(presynapse)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030615|interpro:IPR032466|mint:O08553|rcsb pdb:5UQC|reactome:R-MMU-399956|reactome:R-MMU-437239	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:97yc8TNEPMcGtGNRLvl+KV+DYr010090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P97427	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-773110|uniprotkb:O08554|uniprotkb:O35097|ensembl:ENSMUSP00000031004	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:dpyl1_mouse(display_long)|uniprotkb:Collapsin response mediator protein 1(gene name synonym)|uniprotkb:Unc-33-like phosphoprotein 3(gene name synonym)|uniprotkb:Crmp1(gene name)|psi-mi:Crmp1(display_short)|uniprotkb:Dpysl1(gene name synonym)|uniprotkb:Ulip3(gene name synonym)|uniprotkb:Inactive dihydropyrimidinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_031791.3|ensembl:ENSMUSG00000029121(gene)|ensembl:ENSMUST00000031004(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007411"(axon guidance)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031005"(filamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1904530"(negative regulation of actin filament binding)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030624|interpro:IPR032466|mint:P97427|rcsb pdb:1KCX|reactome:R-MMU-399956	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:/fpPxm3SNtnLKjXWrWOuG0QO3Nk10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P16330	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-772515|uniprotkb:Q61424|uniprotkb:Q8C7C9|uniprotkb:Q91V42|uniprotkb:Q923F3|ensembl:ENSMUSP00000099409	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:cn37_mouse(display_long)|uniprotkb:Cnp(gene name)|psi-mi:Cnp(display_short)|uniprotkb:Cnp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_001139790.1|refseq:NP_034053.2|refseq:XP_017169734.1|ensembl:ENSMUSG00000006782(gene)|ensembl:ENSMUST00000103120(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003723"(RNA binding)|go:"GO:0004113"(2',3'-cyclic-nucleotide 3'-phosphodiesterase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009214"(cyclic nucleotide catabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030551"(cyclic nucleotide binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031143"(pseudopodium)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|interpro:IPR008431(Cyclic nucleotide phosphodiesterase)|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|interpro:IPR027417|mint:P16330|rcsb pdb:2XMI|rcsb pdb:2Y1P|rcsb pdb:2Y3X|rcsb pdb:2YDB|rcsb pdb:2YDC|rcsb pdb:2YDD|rcsb pdb:2YOZ|rcsb pdb:2YP0|rcsb pdb:2YPC|rcsb pdb:2YPE|rcsb pdb:2YPH|rcsb pdb:2YQ9|rcsb pdb:3ZBR|rcsb pdb:3ZBS|rcsb pdb:3ZBZ|rcsb pdb:4WBI|rcsb pdb:4WBL|rcsb pdb:4WC9|rcsb pdb:4WCA|rcsb pdb:4WCB|rcsb pdb:4WCC|rcsb pdb:4WDA|rcsb pdb:4WDB|rcsb pdb:4WDD|rcsb pdb:4WDE|rcsb pdb:4WDF|rcsb pdb:4WDG|rcsb pdb:4WDH|rcsb pdb:4WEX|rcsb pdb:4WFR|rcsb pdb:5AE0	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:z0XniuUAwQzaZTvQmEmctKYNw9810090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P35564	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-738422|ensembl:ENSMUSP00000020637|ensembl:ENSMUSP00000137440	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:calx_mouse(display_long)|uniprotkb:Canx(gene name)|psi-mi:Canx(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_001103969.1|refseq:NP_001103970.1|refseq:NP_031623.1|ensembl:ENSMUSG00000020368(gene)|ensembl:ENSMUST00000020637(transcript)|ensembl:ENSMUST00000179865(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043209"(myelin sheath)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P35564|reactome:R-MMU-2132295|reactome:R-MMU-901042|reactome:R-MMU-9020956|reactome:R-MMU-983170	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:dezCGPoHACqSOEL3QauoQLvMVO010090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P28652	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:P11798	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:O08539	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-775152|uniprotkb:Q62434|ensembl:ENSMUSP00000025239	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:bin1_mouse(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:SH3 domain-containing protein 9(gene name synonym)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Sh3p9(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_033798.1|refseq:XP_006526056.1|ensembl:ENSMUSG00000024381(gene)|ensembl:ENSMUST00000025239(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O08539|reactome:R-MMU-8856828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:VdFcKXTcbayNaahmrT13Dju7kLo10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q6Q477	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-2308323|uniprotkb:Q32ME1|ensembl:ENSMUSP00000119242|ensembl:ENSMUSP00000133187	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:at2b4_mouse(display_long)|uniprotkb:Atp2b4(gene name)|psi-mi:Atp2b4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_998781.1|refseq:NP_001161421.1|refseq:XP_006529786.1|refseq:XP_006529787.1|refseq:XP_006529788.1|dip:DIP-46143N|ensembl:ENSMUSG00000026463(gene)|ensembl:ENSMUST00000143567(transcript)|ensembl:ENSMUST00000165602(transcript)|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036487"(nitric-oxide synthase inhibitor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0097228"(sperm principal piece)|go:"GO:0098736"(negative regulation of the force of heart contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:1900082"(negative regulation of arginine catabolic process)|go:"GO:1901660"(calcium ion export)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903249"(negative regulation of citrulline biosynthetic process)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-MMU-418359|reactome:R-MMU-5578775|reactome:R-MMU-936837	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:IV80bQo2/6AW0+lxIhWZcRIFXBE10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q6P9R4	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-6271853|uniprotkb:E9QK59|uniprotkb:Q6A055|uniprotkb:Q8BYA4|uniprotkb:Q8K227	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:arhgi_mouse(display_long)|uniprotkb:Arhgef18(gene name)|psi-mi:Arhgef18(display_short)|uniprotkb:Kiaa0521(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0045177"(apical part of cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0150105"(protein localization to cell-cell junction)|reactome:R-MMU-8980692|reactome:R-MMU-9013149|interpro:IPR037744|rcsb pdb:6BCB|refseq:NP_598723.3|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035899|reactome:R-MMU-193648|reactome:R-MMU-2173791|interpro:IPR041020|reactome:R-MMU-416482	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:IUJreADJCc2If1ymHyN/QYQFcHY10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TMY8	uniprotkb:Q8K3H0	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-400377|uniprotkb:Q3UJP7|uniprotkb:Q69ZJ9|uniprotkb:Q8BWZ8|uniprotkb:Q8VCJ8|uniprotkb:Q9CUW4|ensembl:ENSMUSP00000042875	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:dp13a_mouse(display_long)|uniprotkb:Appl1(gene name)|psi-mi:Appl1(display_short)|uniprotkb:Dip13a(gene name synonym)|uniprotkb:Kiaa1428(gene name synonym)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730939|imex:IM-26285-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_660256.1|ensembl:ENSMUSG00000040760(gene)|ensembl:ENSMUST00000036570(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|interpro:IPR037929|mint:Q8K3H0|reactome:R-MMU-418889	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/10/11	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:1ZML/W0Qi+jMAeZQ7PXfiHA6YBE10090	rigid:Hrh4vdDPZBDInboQ7ttoBw5YnBA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:P20444	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-6976815|intact:MINT-98140	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:kpca_mouse(display_long)|uniprotkb:Prkca(gene name)|psi-mi:Prkca(display_short)|uniprotkb:Pkca(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001525"(angiogenesis)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002159"(desmosome assembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007611"(learning or memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000707"(positive regulation of dense core granule biogenesis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034663|interpro:IPR035892|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-1250196|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-2179392|reactome:R-MMU-3000170|reactome:R-MMU-399997|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-450520|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|reactome:R-MMU-8853659|refseq:NP_035231.2|mint:P20444|dip:DIP-532N	-	-	comment:mint|function:This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. May play a role in cell motility by phosphorylating CSPG4|function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters|function:Expression of the mutant form UV25 causes malignant transformation of cells	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:mcB2Fkcsk/5w7OhEH93JAec585I10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:P63101	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:P68510	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-444641|uniprotkb:P11576|uniprotkb:P70198|uniprotkb:Q3TGZ9|ensembl:ENSMUSP00000019109	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:1433f_mouse(display_long)|uniprotkb:Ywhah(gene name)|psi-mi:Ywhah(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_035868.1|ensembl:ENSMUSG00000018965(gene)|ensembl:ENSMUST00000019109(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P68510|rcsb pdb:5YQG|go:"GO:0006886"(intracellular protein transport)|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:Ew2uUYIXrZ8nnP52xMnGB6KOCqc10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:P62259	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q9CQV8	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-771608|uniprotkb:O70455|uniprotkb:Q3TY33|uniprotkb:Q3UAN6|ensembl:ENSMUSP00000018470	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:1433b_mouse(display_long)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Ywhab(gene name)|psi-mi:Ywhab(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_061223.2|refseq:XP_006499972.1|reactome:R-MMU-111447|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-170968|reactome:R-MMU-2028269|reactome:R-MMU-392517|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-75035|reactome:R-MMU-9614399|ensembl:ENSMUSG00000018326(gene)|ensembl:ENSMUST00000018470(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:4GNT|rcsb pdb:5F74|rcsb pdb:5WFU|rcsb pdb:5WFX	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:g94luGOxfq+Jbi0ztZ7gbAkp+2A10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q8R5H6	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-774719|uniprotkb:Q91W51|uniprotkb:Q9ERQ9|ensembl:ENSMUSP00000019975|ensembl:ENSMUSP00000101148	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:wasf1_mouse(display_long)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Wasf1(gene name)|psi-mi:Wasf1(display_short)|uniprotkb:Wave1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_114083.1|refseq:XP_006512995.1|ensembl:ENSMUSG00000019831(gene)|ensembl:ENSMUST00000019975(transcript)|ensembl:ENSMUST00000105509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8R5H6|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:t+4F2ap7lNjE/AGuIwMhel4YknU10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q62191	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-6840982	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:ro52_mouse(display_long)|uniprotkb:Trim21(gene name)|psi-mi:Trim21(display_short)|uniprotkb:Ro52(gene name synonym)|uniprotkb:Ssa1(gene name synonym)|uniprotkb:52 kDa Ro protein(gene name synonym)|uniprotkb:52 kDa ribonucleoprotein autoantigen Ro/SS-A(gene name synonym)|uniprotkb:"Ro(SS-A)"(gene name synonym)|uniprotkb:Sjoegren syndrome type A antigen(gene name synonym)|uniprotkb:Tripartite motif-containing protein 21(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM21(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR020457|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:2VOK|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000932"(P-body)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031648"(protein destabilization)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090086"(negative regulation of protein deubiquitination)|go:"GO:1902187"|rcsb pdb:3ZO0|interpro:IPR018957|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035831|reactome:R-MMU-3134975|reactome:R-MMU-983168|interpro:IPR043136	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:4Q3+XUHMvlLeLLws2XCjd66AwOI10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q8BYI9	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-774167|uniprotkb:A2RT70|uniprotkb:O88717|ensembl:ENSMUSP00000107298|ensembl:ENSMUSP00000141553	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:tenr_mouse(display_long)|uniprotkb:Restrictin(gene name synonym)|uniprotkb:Janusin(gene name synonym)|uniprotkb:Neural recognition molecule J1-160/180(gene name synonym)|uniprotkb:Tnr(gene name)|psi-mi:Tnr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_071707.2|refseq:XP_006496805.1|refseq:XP_006496806.1|refseq:XP_006496807.1|ensembl:ENSMUSG00000015829(gene)|ensembl:ENSMUST00000111669(transcript)|ensembl:ENSMUST00000192069(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0045121"(membrane raft)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048692"(negative regulation of axon extension involved in regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072534"(perineuronal net)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098966"(perisynaptic extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR033079|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:Q8BYI9|reactome:R-MMU-3000178	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:K7s7yPGS4RvIe+thCkAZIFGjNRA10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q68FG2	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-2255511|ensembl:ENSMUSP00000008991	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:q68fg2_mouse(display_long)|uniprotkb:Sptbn2(gene name)|psi-mi:Sptbn2(display_short)|uniprotkb:Spnb3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_067262.1|refseq:XP_006531767.1|refseq:XP_006531768.1|ensembl:ENSMUSG00000067889(gene)|ensembl:ENSMUST00000008991(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008091"(spectrin)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0030534"(adult behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051693"(actin filament capping)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098918"(structural constituent of synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:0099189"(postsynaptic spectrin-associated cytoskeleton)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-MMU-2132295|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:2F7U0dl21KxXpc9Z2sk7D/wzQvM10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q62261	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:P16546	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-911063|uniprotkb:A3KGU6|uniprotkb:Q8K380|uniprotkb:Q9CT05|uniprotkb:A3KGU8|ensembl:ENSMUSP00000092697	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:sptn1_mouse(display_long)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym)|uniprotkb:Spta2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	dip:DIP-37712N|ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000095083(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032437"(cuticular plate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:P16546|reactome:R-MMU-264870|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:UVB6Kv+PBlqDH3OLoGjxm5oYVPQ10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:P97797	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-644732|uniprotkb:O08907|uniprotkb:O35924|uniprotkb:O88555|uniprotkb:O88556|uniprotkb:P97796|uniprotkb:Q8R559|uniprotkb:Q9QX57|uniprotkb:Q9WTN4|ensembl:ENSMUSP00000049022|ensembl:ENSMUSP00000124048|uniprotkb:A0A0R4J1Z7|uniprotkb:E0CYM8|uniprotkb:E9QPT7	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:shps1_mouse(display_long)|uniprotkb:Inhibitory receptor SHPS-1(gene name synonym)|uniprotkb:Signal-regulatory protein alpha-1(gene name synonym)|uniprotkb:MyD-1 antigen(gene name synonym)|uniprotkb:Brain Ig-like molecule with tyrosine-based activation motifs(gene name synonym)|uniprotkb:p84(gene name synonym)|uniprotkb:CD172 antigen-like family member A(gene name synonym)|uniprotkb:Sirp(gene name synonym)|uniprotkb:Sirpa(gene name)|psi-mi:Sirpa(display_short)|uniprotkb:Bit(gene name synonym)|uniprotkb:Myd1(gene name synonym)|uniprotkb:Shps1(gene name synonym)|uniprotkb:Ptpns1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:XP_017172050.1|refseq:NP_001277950.1|refseq:XP_006499049.1|refseq:XP_017172057.1|refseq:NP_001171118.1|refseq:NP_031573.2|ensembl:ENSMUSG00000037902(gene)|ensembl:ENSMUST00000049262(transcript)|ensembl:ENSMUST00000161620(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071349"(cellular response to interleukin-12)|go:"GO:0071641"(negative regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0097530"(granulocyte migration)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P97797|rcsb pdb:2YZ1|reactome:R-MMU-202733|reactome:R-MMU-2172127|reactome:R-MMU-391160|reactome:R-MMU-6798695|go:"GO:0050765"(negative regulation of phagocytosis)|refseq:NP_001277948.1|refseq:NP_001277949.1|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|refseq:XP_017172058.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:v0FShADF6c2OXAD2gmm2P0Kkv8c10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q4ACU6	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q80Z38	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-770338|uniprotkb:E9QPH7|uniprotkb:Q3UTK4|uniprotkb:Q5DU07	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:shan2_mouse(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)|uniprotkb:Kiaa1022(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_001074839.2|refseq:NP_001106844.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001452(Src homology-3)|refseq:XP_006508596.1|reactome:R-MMU-6794361|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0043005"(neuron projection)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:OTohbAMxKtx7/WWwWXDc+c24HvQ10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:D3YZU1	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-2314988|ensembl:ENSMUSP00000103571	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:shan1_mouse(display_long)|uniprotkb:Shank1(gene name)|psi-mi:Shank1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_001029287.1|refseq:XP_006540927.1|ensembl:ENSMUSG00000038738(gene)|ensembl:ENSMUST00000107938(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:TbxBmjjabypLqTlAx9zbkSAAzpk10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:P63328	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-397208|uniprotkb:P12816|uniprotkb:P20652|uniprotkb:Q3UCU1|uniprotkb:Q64135|ensembl:ENSMUSP00000053101	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:pp2ba_mouse(display_long)|uniprotkb:Ppp3ca(gene name)|psi-mi:Ppp3ca(display_short)|uniprotkb:Calna(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_032939.1|refseq:NP_001280551.1|ensembl:ENSMUSG00000028161(gene)|ensembl:ENSMUST00000056758(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042383"(sarcolemma)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P63328|rcsb pdb:4ORB|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|dip:DIP-31543N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:98yAyDGZZxKYOv22ejceyfJbvao10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:P17742	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-1206043|uniprotkb:Q9CWJ5|uniprotkb:Q9R137|ensembl:ENSMUSP00000117987	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:ppia_mouse(display_long)|uniprotkb:Ppia(gene name)|psi-mi:Ppia(display_short)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:SP18(gene name synonym)|uniprotkb:Rotamase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_032933.1|reactome:R-MMU-210991|reactome:R-MMU-6798695|rcsb pdb:6FK1|ensembl:ENSMUSG00000071866(gene)|ensembl:ENSMUST00000132846(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:P17742	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:VwIoW2yfdaAEwZj6MfekFYqkZjw10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q9Z0E0	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-775082|uniprotkb:Q3TCW4|uniprotkb:Q80TW1|uniprotkb:Q91YH7|uniprotkb:Q9CW81|uniprotkb:Q9QUQ0|ensembl:ENSMUSP00000030637|ensembl:ENSMUSP00000101722	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:ncdn_mouse(display_long)|uniprotkb:Sfap75(gene name synonym)|uniprotkb:Norbin(gene name synonym)|uniprotkb:M-Sema F-associating protein of 75 kDa(gene name synonym)|uniprotkb:Ncdn(gene name)|psi-mi:Ncdn(display_short)|uniprotkb:Kiaa0607(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_036116.3|refseq:XP_006503181.1|refseq:XP_006503182.1|ensembl:ENSMUSG00000028833(gene)|ensembl:ENSMUST00000030637(transcript)|ensembl:ENSMUST00000106116(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045453"(bone resorption)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0098794"(postsynapse)|interpro:IPR008709(Neurochondrin)|interpro:IPR016024(Armadillo-type fold)|mint:Q9Z0E0	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:afzLC/h+kiexMllkeyxpn1btb1U10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:P13595	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-774943|uniprotkb:Q61949|uniprotkb:Q61950|intact:EBI-1018667|uniprotkb:P13594|uniprotkb:Q6LBU8|uniprotkb:Q8BQ96|uniprotkb:Q8C4B2|uniprotkb:Q921P2|uniprotkb:Q9R2A7	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:ncam1_mouse(display_long)|uniprotkb:Ncam1(gene name)|psi-mi:Ncam1(display_short)|uniprotkb:Ncam(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_001074914.1|refseq:NP_001106675.1|refseq:NP_035005.2|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR009138(Neural cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|refseq:NP_001297994.1|interpro:IPR033019|interpro:IPR036116|interpro:IPR036179|mint:P13595|go:"GO:0001928"(regulation of exocyst assembly)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0019902"(phosphatase binding)|go:"GO:0021794"(thalamus development)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0048666"(neuron development)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2001260"(regulation of semaphorin-plexin signaling pathway)|rcsb pdb:2NCM|rcsb pdb:3NCM|reactome:R-MMU-375165|reactome:R-MMU-419037|reactome:R-MMU-445144|reactome:R-MMU-5673001	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:bEVNNXNFliR5XooeBmVJ5PgeNwc10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q61879	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-400918|uniprotkb:Q5SV63|ensembl:ENSMUSP00000099671	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:myh10_mouse(display_long)|uniprotkb:Myh10(gene name)|psi-mi:Myh10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_780469.1|ensembl:ENSMUSG00000020900(gene)|ensembl:ENSMUST00000102611(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001764"(neuron migration)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0006887"(exocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007097"(nuclear migration)|go:"GO:0007155"(cell adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0021592"(fourth ventricle development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021678"(third ventricle development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035904"(aorta development)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0070650"(actin filament bundle distribution)|go:"GO:0097513"(myosin II filament)|dip:DIP-31956N|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q61879|reactome:R-MMU-5627123	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:DE0ILvXp+FsQ8J8yXJ38FaeQtzM10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:O35099	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:A2AHG0	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-16730688|ensembl:ENSMUSP00000037109|ensembl:ENSMUSP00000086990|uniprotkb:A2AHF9|uniprotkb:Q3TSY0|uniprotkb:Q6PE51	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:lzts3_mouse(display_long)|uniprotkb:ProSAP-interacting protein 1(gene name synonym)|uniprotkb:Lzts3(gene name)|psi-mi:Lzts3(display_short)|uniprotkb:Prosapip1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	ensembl:ENSMUSG00000037703(gene)|ensembl:ENSMUST00000045761(transcript)|ensembl:ENSMUST00000089561(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0045202"(synapse)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|interpro:IPR033295|refseq:NP_001277956.1|refseq:NP_001277957.1|refseq:NP_922936.3|refseq:XP_017173693.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:5+8Res6l89KP2ziP7nHoTRP25p010090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q3UVX5	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-8795045|ensembl:ENSMUSP00000114927	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:grm5_mouse(display_long)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|reactome:R-MMU-416476|reactome:R-MMU-420499|reactome:R-MMU-6794361|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|ensembl:ENSMUSG00000049583(gene)|ensembl:ENSMUST00000155358(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|refseq:XP_011239945.1|refseq:NP_001137306.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:pA3IUBq9r3mGn7M8R2qnAaYqaT810090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:P97772	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-396863|uniprotkb:Q6AXG4|uniprotkb:Q9EPV6|ensembl:ENSMUSP00000037255	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:grm1_mouse(display_long)|uniprotkb:Grm1(gene name)|psi-mi:Grm1(display_short)|uniprotkb:Gprc1a(gene name synonym)|uniprotkb:Mglur1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_001107805.1|refseq:NP_058672.1|refseq:XP_006512612.1|ensembl:ENSMUSG00000019828(gene)|ensembl:ENSMUST00000044306(transcript)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|mint:P97772|reactome:R-MMU-416476|reactome:R-MMU-420499|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:WJAWpEEcB6PLmPlnp8R9/mV+rW410090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q9Z0G0	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-300855|ensembl:ENSMUSP00000019577	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:gipc1_mouse(display_long)|uniprotkb:Gipc1(gene name)|psi-mi:Gipc1(display_short)|uniprotkb:Gipc(gene name synonym)|uniprotkb:Semcap1(gene name synonym)|uniprotkb:RGS19-interacting protein 1(gene name synonym)|uniprotkb:GAIP C-terminus-interacting protein(gene name synonym)|uniprotkb:RGS-GAIP-interacting protein(gene name synonym)|uniprotkb:Synectin(gene name synonym)|uniprotkb:SemaF cytoplasmic domain-associated protein 1(gene name synonym)|uniprotkb:Rgs19ip1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	ensembl:ENSMUSG00000019433(gene)|ensembl:ENSMUST00000019577(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014047"(glutamate secretion)|go:"GO:0016020"(membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR017379(Uncharacterised conserved protein UCP038083, PDZ)|interpro:IPR036034|mint:Q9Z0G0|rcsb pdb:5V6B|rcsb pdb:5V6E|rcsb pdb:5V6T|rcsb pdb:7NRN|refseq:NP_061241.1|dip:DIP-33281N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:qOV0/hc2ei7VPYVbbWqUkjF8aBw10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q9D8Y0	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-2694004|uniprotkb:Q9D0P4	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:efhd2_mouse(display_long)|uniprotkb:Efhd2(gene name)|psi-mi:Efhd2(display_short)|uniprotkb:Sws1(gene name synonym)|uniprotkb:Swiprosin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	interpro:IPR011992(EF-Hand type)|interpro:IPR002048(Calcium-binding EF-hand)|reactome:R-MMU-9013405|interpro:IPR040365|go:"GO:0005509"(calcium ion binding)|go:"GO:0045121"(membrane raft)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:vr6DjwFcdfiyAcFdthG6Vn2q08I10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q8R1A4	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-776274|uniprotkb:Q45V78|uniprotkb:Q5PRE6|uniprotkb:Q6PJ17|uniprotkb:Q9CSB6|uniprotkb:Q9CXM7	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:dock7_mouse(display_long)|uniprotkb:Gm430(gene name synonym)|uniprotkb:Dock7(gene name)|psi-mi:Dock7(display_short)|uniprotkb:Kiaa1771(gene name synonym)|uniprotkb:Mnlt(gene name synonym)|uniprotkb:Protein moonlight(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	interpro:IPR027357|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR043162|interpro:IPR043161|interpro:IPR026791|interpro:IPR027007|interpro:IPR035892|interpro:IPR037808|mint:Q8R1A4|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043473"(pigmentation)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|reactome:R-MMU-8875555|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-983231	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:T4W30iJF8XaTuK57c9vlJFr9gpg10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:P39053	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-397785|ensembl:ENSMUSP00000122679|uniprotkb:A2AN50|uniprotkb:A2AN51|uniprotkb:A2AN54|uniprotkb:A2AN55|uniprotkb:Q3UNM1|uniprotkb:Q5DTN7|uniprotkb:Q61358|uniprotkb:Q61359|uniprotkb:Q61360|uniprotkb:Q6PDM5|uniprotkb:Q8JZZ4|uniprotkb:Q9CSY7|uniprotkb:Q9QXX1	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:dyn1_mouse(display_long)|uniprotkb:Dnm1(gene name)|psi-mi:Dnm1(display_short)|uniprotkb:Dnm(gene name synonym)|uniprotkb:Kiaa4093(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_034195.2|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:P39053|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|ensembl:ENSMUSG00000026825(gene)|ensembl:ENSMUST00000139624(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904645"(response to amyloid-beta)|refseq:NP_001288666.1|refseq:XP_006497721.2|refseq:XP_006497722.2|refseq:XP_006497723.2|refseq:XP_006497724.2|refseq:XP_006497718.2|refseq:XP_017170817.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:wtPz3gwyxU6tAgh5091LQpt099I10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q9D415	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:O08967	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-16725278|ensembl:ENSMUSP00000112157|uniprotkb:Q8CI93	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:cyh3_mouse(display_long)|uniprotkb:ARF nucleotide-binding site opener 3(gene name synonym)|uniprotkb:General receptor of phosphoinositides 1(gene name synonym)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 3(gene name synonym)|uniprotkb:SEC7 homolog C(gene name synonym)|uniprotkb:Cyth3(gene name)|psi-mi:Cyth3(display_short)|uniprotkb:Grp1(gene name synonym)|uniprotkb:Pscd3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	ensembl:ENSMUSG00000018001(gene)|ensembl:ENSMUST00000116456(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0090162"(establishment of epithelial cell polarity)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|rcsb pdb:1FGY|rcsb pdb:1FGZ|rcsb pdb:1FHW|rcsb pdb:1FHX|rcsb pdb:1U2B|rcsb pdb:2R09|rcsb pdb:2R0D|rcsb pdb:6BBP|rcsb pdb:6BBQ|reactome:R-MMU-6811438|refseq:NP_035312.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:SUSlHPxCGtFJpZM5a3R/pIpOFXU10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q69Z26	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-16730638|ensembl:ENSMUSP00000086616|ensembl:ENSMUSP00000108889|uniprotkb:Q14BL8|uniprotkb:Q8BRT6|uniprotkb:Q8CBD3	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:cntn4_mouse(display_long)|uniprotkb:Brain-derived immunoglobulin superfamily protein 2(gene name synonym)|uniprotkb:Cntn4(gene name)|psi-mi:Cntn4(display_short)|uniprotkb:Kiaa3024(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	ensembl:ENSMUSG00000064293(gene)|ensembl:ENSMUST00000089208(transcript)|ensembl:ENSMUST00000113264(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045665"(negative regulation of neuron differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR043204|mint:Q69Z26|rcsb pdb:3JXA|rcsb pdb:3KLD|rcsb pdb:5E4S|refseq:NP_001103219.1|refseq:NP_001103221.1|refseq:NP_766592.2|refseq:XP_006506256.1|refseq:XP_006506257.1|refseq:XP_006506258.1|refseq:XP_017177088.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:m4itt/n8Nr9eKpzaSmeeTyA9rPw10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:P11798	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:P62204	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:O08539	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-775152|uniprotkb:Q62434|ensembl:ENSMUSP00000025239	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:bin1_mouse(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:SH3 domain-containing protein 9(gene name synonym)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Sh3p9(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_033798.1|refseq:XP_006526056.1|ensembl:ENSMUSG00000024381(gene)|ensembl:ENSMUST00000025239(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O08539|reactome:R-MMU-8856828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:VdFcKXTcbayNaahmrT13Dju7kLo10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z2Y3	uniprotkb:Q3UHD9	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-771911|uniprotkb:Q5DU45|ensembl:ENSMUSP00000043466	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:agap2_mouse(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Kiaa0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16730716|imex:IM-26285-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_001028435.1|refseq:NP_001287943.1|ensembl:ENSMUSG00000025422(gene)|ensembl:ENSMUST00000039259(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|go:"GO:0005768"(endosome)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/05/28	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:yq2lQtfk+FPqgT++CxAx2CS69nE10090	rigid:4ShxrJ9Jru4tpEPzyAYL4G+MeiY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q6PDG5	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-3870565|uniprotkb:Q6P6P3|ensembl:ENSMUSP00000100868	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:smrc2_mouse(display_long)|uniprotkb:Smarcc2(gene name)|psi-mi:Smarcc2(display_short)|uniprotkb:Baf170(gene name synonym)|uniprotkb:BRG1-associated factor 170(gene name synonym)|uniprotkb:SWI/SNF complex 170 kDa subunit(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001107568.1|refseq:NP_001107569.1|refseq:NP_937803.1|dip:DIP-48884N|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0042393"(histone binding)|ensembl:ENSMUSG00000025369(gene)|go:"GO:0043044"|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000953(Chromo domain)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR007526(SWIRM)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR032448|interpro:IPR032450|interpro:IPR032451|interpro:IPR036388|interpro:IPR036420|interpro:IPR038044|mint:Q6PDG5|reactome:R-MMU-3214858|reactome:R-MMU-8939243|ensembl:ENSMUST00000105235(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:v8cjo/1nUFl5vd96cKMcY8LA8M010090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q61315	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-7848277|uniprotkb:Q62044|intact:UNK-5461725	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:apc_mouse(display_long)|uniprotkb:Apc(gene name)|psi-mi:Apc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0001822"(kidney development)|go:"GO:0001942"(hair follicle development)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009798"(axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042483"(negative regulation of odontogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043588"(skin development)|go:"GO:0044295"(axonal growth cone)|go:"GO:0031253"(cell projection membrane)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044337"(canonical Wnt signaling pathway involved in positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051171"(regulation of nitrogen compound metabolic process)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070852"(cell body fiber)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000211"(regulation of glutamate metabolic process)|rcsb pdb:1VJ6|reactome:R-MMU-111465|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3769402|reactome:R-MMU-4641262|reactome:R-MMU-5689896|interpro:IPR032038|mint:Q61315|interpro:IPR009224(SAMP)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009232(EB-1 binding)|interpro:IPR026818|interpro:IPR011989(Armadillo-like helical)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR026836|interpro:IPR036149|interpro:IPR041257	-	-	function:Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. APC activity is correlated with its phosphorylation state|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:5LB5NjRyV0VFe8xzCkg3/o+44g410090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P83510	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	-	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q01065	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-8320318|intact:MINT-4106830|uniprotkb:O35384|ensembl:ENSMUSP00000023132	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:pde1b_mouse(display_long)|uniprotkb:Pde1b(gene name)|psi-mi:Pde1b(display_short)|uniprotkb:Pde1b1(gene name synonym)|uniprotkb:63 kDa Cam-PDE(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_032826.1|ensembl:ENSMUSG00000022489(gene)|ensembl:ENSMUST00000023132(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004112"(cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004117"(calmodulin-dependent cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048101"(calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR013706(3'5'-cyclic nucleotide phosphodiesterase N-terminal)|interpro:IPR023088|interpro:IPR023174|interpro:IPR036971|mint:Q01065|reactome:R-MMU-111957|reactome:R-MMU-418457|reactome:R-MMU-418555	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:oT81/b4qL7Wsx1zW1D+c7fzwBpc10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P97379	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-8319813|intact:MINT-1858459|uniprotkb:Q9R1B8|uniprotkb:Q3UL55|ensembl:ENSMUSP00000128244|ensembl:ENSMUSP00000128353|ensembl:ENSMUSP00000144456	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:g3bp2_mouse(display_long)|uniprotkb:G3bp2(gene name)|psi-mi:G3bp2(display_short)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_035946.2|refseq:NP_001074263.1|refseq:NP_001074266.1|refseq:XP_006534990.1|refseq:XP_006534991.1|ensembl:ENSMUSG00000029405(gene)|ensembl:ENSMUST00000164378(transcript)|ensembl:ENSMUST00000169094(transcript)|ensembl:ENSMUST00000202258(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:P97379	-	-	function:Probable scaffold protein that may be involved in mRNA transport|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:1MhDKzi09if4Beb23/9+ZTB0xKM10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P52479	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-8327299|uniprotkb:Q6ZQG9|uniprotkb:Q91VY7|uniprotkb:Q3TZB8|intact:MINT-1870263|uniprotkb:Q3U5E0|uniprotkb:Q3T9L4|uniprotkb:Q3TNN5|ensembl:ENSMUSP00000104616	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ubp10_mouse(display_long)|uniprotkb:Usp10(gene name)|psi-mi:Usp10(display_short)|uniprotkb:Ode-1(gene name synonym)|uniprotkb:Uchrp(gene name synonym)|uniprotkb:Kiaa0190(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001297559.1|refseq:NP_033488.1|ensembl:ENSMUSG00000031826(gene)|ensembl:ENSMUST00000108988(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:P52479|reactome:R-MMU-5656169|reactome:R-MMU-5689880	-	-	comment:mint|function:Ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:tdoxBRcosuC3GGqMGB5pBKA9pKc10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:F6ZDS4	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-8317182|intact:MINT-4119134|uniprotkb:Q8R4A0|uniprotkb:Q921B9|ensembl:ENSMUSP00000117616	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:tpr_mouse(display_long)|uniprotkb:Tpr(gene name)|psi-mi:Tpr(display_short)|uniprotkb:NPC-associated intranuclear protein(gene name synonym)|uniprotkb:Translocated promoter region and nuclear basket protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_598541.3|ensembl:ENSMUSG00000006005(gene)|ensembl:ENSMUST00000124973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003682"(chromatin binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006404"(RNA import into nucleus)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010965"(regulation of mitotic sister chromatid separation)|go:"GO:0015631"(tubulin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR012929(Tetratricopeptide, MLP1/MLP2-like)|mint:F6ZDS4|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822|reactome:R-MMU-191859|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-4615885|reactome:R-MMU-5578749	-	-	comment:"fragmentation type: fragment"|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:tP8N2Pd6AcwYnEHlsKU6zt3Ess410090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8K4L3	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-8401679|intact:MINT-4136191|uniprotkb:E9Q983|ensembl:ENSMUSP00000025079|ensembl:ENSMUSP00000115078|ensembl:ENSMUSP00000119803	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:svil_mouse(display_long)|uniprotkb:Svil(gene name)|psi-mi:Svil(display_short)|uniprotkb:Archvillin(gene name synonym)|uniprotkb:p205/p250(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:XP_011245180.1|refseq:NP_694793.1|refseq:NP_001334378.1|ensembl:ENSMUSG00000024236(gene)|ensembl:ENSMUST00000025079(transcript)|ensembl:ENSMUST00000126977(transcript)|ensembl:ENSMUST00000140448(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0042995"(cell projection)|go:"GO:0043034"(costamere)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR003128(Villin headpiece)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR015628(Supervillin)|interpro:IPR029006|interpro:IPR036886|mint:Q8K4L3|go:"GO:0030054"(cell junction)	-	-	comment:mint|function:"Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 2 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:KG5cW2QzOc2/WKKunit3VmhpkYY10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q3UTJ2	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-8345744|uniprotkb:Q80TS1|intact:MINT-1853612|uniprotkb:Q3USC6|uniprotkb:Q8BX47|uniprotkb:Q8CHU0|uniprotkb:Q8BLW9|intact:MINT-4116161|uniprotkb:Q8BJL6|uniprotkb:Q8BJU3	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:srbs2_mouse(display_long)|uniprotkb:Sorbs2(gene name)|psi-mi:Sorbs2(display_short)|uniprotkb:Arg/Abl-interacting protein 2(gene name synonym)|uniprotkb:Argbp2(gene name synonym)|uniprotkb:Kiaa0777(gene name synonym)|uniprotkb:Arg-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001297636.1|interpro:IPR003127(Sorbin-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR028506|interpro:IPR036028|mint:Q3UTJ2|refseq:XP_006509449.1|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR001452(Src homology-3)	-	-	comment:"fragmentation type: fragment"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:2sKDQux/2IV7mW8l6LK36D3qlqw10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q7TN74	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-7385297|intact:MINT-4600266|ensembl:ENSMUSP00000046906	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:q7tn74_mouse(display_long)|uniprotkb:Ppp1r9a(gene name)|psi-mi:Ppp1r9a(display_short)|uniprotkb:Neurabin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_853626.1|ensembl:ENSMUSG00000032827(gene)|ensembl:ENSMUST00000035813(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|refseq:XP_006505142.1|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1990761"(growth cone lamellipodium)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR029994|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q7TN74|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:Wxg3Z5Mlh48qmQ+FMbR/MqquP7k10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8VEB4	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-8334111|uniprotkb:Q3TCB1|intact:MINT-4100834|uniprotkb:Q3U303|ensembl:ENSMUSP00000034377	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:pag15_mouse(display_long)|uniprotkb:Pla2g15(gene name)|psi-mi:Pla2g15(display_short)|uniprotkb:Lypla3(gene name synonym)|uniprotkb:1-O-acylceramide synthase(gene name synonym)|uniprotkb:Lysosomal phospholipase A2(gene name synonym)|uniprotkb:Lysophospholipase 3(gene name synonym)|uniprotkb:LCAT-like lysophospholipase(gene name synonym)|uniprotkb:Lysosomal phospholipase A and acyltransferase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_598553.1|ensembl:ENSMUSG00000031903(gene)|ensembl:ENSMUST00000034377(transcript)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006650"(glycerophospholipid metabolic process)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0006658"(phosphatidylserine metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0008970"(phospholipase A1 activity)|go:"GO:0016020"(membrane)|go:"GO:0016411"(acylglycerol O-acyltransferase activity)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046338"(phosphatidylethanolamine catabolic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046471"(phosphatidylglycerol metabolic process)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0052739"(phosphatidylserine 1-acylhydrolase activity)|go:"GO:0052740"(1-acyl-2-lysophosphatidylserine acylhydrolase activity)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0102567"|go:"GO:0102568"|interpro:IPR003386("Lecithin:cholesterol acyltransferase")|interpro:IPR029058|mint:Q8VEB4|reactome:R-MMU-1483115	-	-	comment:mint|function:Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:HcB5qCbc00WYH3v29OITy4Q6TzQ10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q91WK0	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-7996195|uniprotkb:Q9CU89|uniprotkb:Q8BVD1|intact:MINT-5102469	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:lrrf2_mouse(display_long)|uniprotkb:Lrrfip2(gene name)|psi-mi:Lrrfip2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	interpro:IPR019139|refseq:NP_082018.1|refseq:NP_001158310.1|mint:Q91WK0|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035660"(MyD88-dependent toll-like receptor 4 signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)	-	-	comment:mint|function:May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:oDgIYHLW2PlrYk0pvnqMRhdnG1U10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q60960	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-8573008|ensembl:ENSMUSP00000004054|uniprotkb:Q3TF32|intact:MINT-4597096	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ima5_mouse(display_long)|uniprotkb:Kpna1(gene name)|psi-mi:Kpna1(display_short)|uniprotkb:Rch2(gene name synonym)|uniprotkb:Importin alpha-S1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-1(gene name synonym)|uniprotkb:SRP1-beta(gene name synonym)|uniprotkb:RAG cohort protein 2(gene name synonym)|uniprotkb:Nucleoprotein interactor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:XP_006521877.1|ensembl:ENSMUSG00000022905(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014841"(skeletal muscle satellite cell proliferation)|go:"GO:0014901"(satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0030425"(dendrite)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061608"(nuclear import signal receptor activity)|ensembl:ENSMUST00000004054(transcript)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|reactome:R-MMU-140342|reactome:R-MMU-909733|refseq:NP_032491.2|dip:DIP-48614N	-	-	comment:mint|function:"Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:V2skjc1VDIOFauddcuTX4cR01ek10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8K2Q9	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-8345422|uniprotkb:Q8C4F6|uniprotkb:Q5DTW5|intact:MINT-4117450|ensembl:ENSMUSP00000041378	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:shot1_mouse(display_long)|uniprotkb:Shtn1(gene name)|psi-mi:Shtn1(display_short)|uniprotkb:Kiaa1598(gene name synonym)|uniprotkb:Shootin1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001107784.1|refseq:NP_780381.1|ensembl:ENSMUSG00000041362(gene)|ensembl:ENSMUST00000047511(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019894"(kinesin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060327"(cytoplasmic actin-based contraction involved in cell motility)|go:"GO:0061163"(endoplasmic reticulum polarization)|go:"GO:0061573"(actin filament bundle retrograde transport)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR024849|mint:Q8K2Q9	-	-	comment:mint|function:"Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K Activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:yznEpNOVpIXGoX9hyI+UuiA6elY10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8CGP6	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-8573727|ensembl:ENSMUSP00000089336|intact:MINT-4606203	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:h2a1h_mouse(display_long)|uniprotkb:H2ac12(gene name)|psi-mi:H2ac12(display_short)|uniprotkb:H2A-clustered histone 12(gene name synonym)|uniprotkb:Hist1h2ah(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000069302(gene)|ensembl:ENSMUST00000091742(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|rcsb pdb:2F8N|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-212300|reactome:R-MMU-2299718|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-3214815|reactome:R-MMU-3214858|reactome:R-MMU-427359|reactome:R-MMU-427413|reactome:R-MMU-5250924|reactome:R-MMU-5578749|reactome:R-MMU-5625886|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-5689901|reactome:R-MMU-606279|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8936459|reactome:R-MMU-9018519|reactome:R-MMU-9670095|refseq:NP_783590.1	-	-	function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:pmWHTfvVU6PVP8ZlETv+BnTpug810090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q61584	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	-	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8VEH5	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-8317423|ensembl:ENSMUSP00000052904|ensembl:ENSMUSP00000120245|intact:MINT-4094544|uniprotkb:Q80TS4	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:epmip_mouse(display_long)|uniprotkb:Epm2aip1(gene name)|psi-mi:Epm2aip1(display_short)|uniprotkb:Kiaa0766(gene name synonym)|uniprotkb:Laforin-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000046785(gene)|ensembl:ENSMUST00000060711(transcript)|ensembl:ENSMUST00000135807(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR026630|interpro:IPR040647|mint:Q8VEH5|refseq:NP_780475.1	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:Moh1l/PjRcvRTBqsTbINe9OJKvs10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9WUM4	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-8316222|ensembl:ENSMUSP00000004646|intact:MINT-4091604|uniprotkb:Q8VCQ5|uniprotkb:Q499X7	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:cor1c_mouse(display_long)|uniprotkb:Coro1c(gene name)|psi-mi:Coro1c(display_short)|uniprotkb:Coronin-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000004530(gene)|ensembl:ENSMUST00000004646(transcript)|go:"GO:0000147"(actin cortical patch assembly)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016197"(endosomal transport)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0090148"(membrane fission)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097750"(endosome membrane tubulation)|go:"GO:0140285"(endosome fission)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027333|interpro:IPR036322|mint:Q9WUM4|refseq:NP_035909.2	-	-	comment:mint|function:May be involved in cytokinesis, motility, and signal transduction	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:Td/jSJSpQwBMVL43ZWfzJdkcURA10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P80318	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-772361|ensembl:ENSMUSP00000001452	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:tcpg_mouse(display_long)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:Matricin(gene name synonym)|uniprotkb:mTRiC-P5(gene name synonym)|uniprotkb:Cct3(gene name)|psi-mi:Cct3(display_short)|uniprotkb:Cctg(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_033966.1|dip:DIP-32344N|ensembl:ENSMUSG00000001416(gene)|ensembl:ENSMUST00000001452(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P80318|rcsb pdb:1GML|rcsb pdb:1GN1|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6814122	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:+jrWcoDzrkHivHA/h3aApt0gBFU10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q3UHB8	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731180|ensembl:ENSMUSP00000072982|uniprotkb:Q6NXJ5	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:cc177_mouse(display_long)|uniprotkb:Ccdc177(gene name)|psi-mi:Ccdc177(display_short)|uniprotkb:Gm1568(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000062961(gene)|ensembl:ENSMUST00000073251(transcript)|interpro:IPR029090|mint:Q3UHB8|refseq:NP_001008423.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:objGQkpHL5Pr4FZHhKDHYGjAVUU10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8CH18	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-645246|uniprotkb:Q6AXC9|uniprotkb:Q6PAR2|uniprotkb:Q80XE4|uniprotkb:Q8BJY0|uniprotkb:Q8BVN2|uniprotkb:Q8CGG1|uniprotkb:Q9CSR5|uniprotkb:Q05BR1|uniprotkb:Q05DK6|ensembl:ENSMUSP00000020268|ensembl:ENSMUSP00000151895	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ccar1_mouse(display_long)|uniprotkb:Cell cycle and apoptosis regulatory protein 1(gene name synonym)|uniprotkb:Ccar1(gene name)|psi-mi:Ccar1(display_short)|uniprotkb:Carp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_080477.1|refseq:XP_006514057.1|refseq:XP_006514058.1|refseq:XP_006514059.1|refseq:XP_006514060.1|refseq:XP_011241839.1|ensembl:ENSMUSG00000020074(gene)|ensembl:ENSMUST00000020268(transcript)|ensembl:ENSMUST00000219527(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|interpro:IPR036361|mint:Q8CH18|reactome:R-MMU-72163	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:fipMhp0uguP4AXVte036ScUyq5g10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9WVG6	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-4414343|uniprotkb:Q3TYB9|uniprotkb:Q8K1Y5|uniprotkb:Q91W24|uniprotkb:Q99KX8|ensembl:ENSMUSP00000034703	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:carm1_mouse(display_long)|uniprotkb:Carm1(gene name)|psi-mi:Carm1(display_short)|uniprotkb:Prmt4(gene name synonym)|uniprotkb:Coactivator-associated arginine methyltransferase 1(gene name synonym)|uniprotkb:Protein arginine N-methyltransferase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_067506.2|refseq:NP_694781.1|dip:DIP-44593N|ensembl:ENSMUSG00000032185(gene)|ensembl:ENSMUST00000034703(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006479"(protein methylation)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034969"(histone arginine methylation)|go:"GO:0034970"(histone H3-R2 methylation)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902415"(regulation of mRNA binding)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020989|interpro:IPR025799|interpro:IPR029063|mint:Q9WVG6|rcsb pdb:2V74|rcsb pdb:2V7E|rcsb pdb:5IH3|rcsb pdb:5IS6|rcsb pdb:5IS7|rcsb pdb:5IS8|rcsb pdb:5IS9|rcsb pdb:5ISA|rcsb pdb:5ISB|rcsb pdb:5ISC|rcsb pdb:5ISD|rcsb pdb:5ISE|rcsb pdb:5ISF|rcsb pdb:5ISG|rcsb pdb:5ISH|rcsb pdb:5ISI|rcsb pdb:5K8V|rcsb pdb:5K8W|rcsb pdb:5K8X|rcsb pdb:5LGP|rcsb pdb:5LGQ|rcsb pdb:5LGR|rcsb pdb:5LGS|rcsb pdb:5LKJ|rcsb pdb:5LV2|rcsb pdb:5LV3|rcsb pdb:5NTC|rcsb pdb:5TBH|rcsb pdb:5TBI|rcsb pdb:5TBJ|reactome:R-MMU-3214858|reactome:R-MMU-400206|reactome:R-MMU-9018519|reactome:R-MMU-9707564|go:"GO:0035642"("histone methyltransferase activity (H3-R17 specific)")	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:OhPIJ/O/PCm8s8oJoebgdYV133s10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q60865	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-647767|uniprotkb:Q6IMN3|uniprotkb:Q7TT26|uniprotkb:Q60758|uniprotkb:Q61620|ensembl:ENSMUSP00000028607|ensembl:ENSMUSP00000106777	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:capr1_mouse(display_long)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:Caprin1(gene name)|psi-mi:Caprin1(display_short)|uniprotkb:Gpiap(gene name synonym)|uniprotkb:Gpiap1(gene name synonym)|uniprotkb:Gpip137(gene name synonym)|uniprotkb:M11s1(gene name synonym)|uniprotkb:G5E5(orf name)|uniprotkb:Rng105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001104759.1|refseq:NP_001104760.1|refseq:NP_001104761.1|refseq:NP_001104762.1|refseq:NP_058019.2|ensembl:ENSMUSG00000027184(gene)|ensembl:ENSMUST00000028607(transcript)|ensembl:ENSMUST00000111147(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q60865	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:e+Dcb+82jx+CoLhlGBbdSG62dPU10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P62204	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:B2RQC6	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-3043834|ensembl:ENSMUSP00000013773|uniprotkb:B7ZN27	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:pyr1_mouse(display_long)|uniprotkb:Cad(gene name)|psi-mi:Cad(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000013629(gene)|ensembl:ENSMUST00000013773(transcript)|go:"GO:0002134"(UTP binding)|go:"GO:0004070"(aspartate carbamoyltransferase activity)|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004151"(dihydroorotase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014075"(response to amine)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016597"(amino acid binding)|go:"GO:0017144"|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0001889"(liver development)|go:"GO:0031000"(response to caffeine)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044205"('de novo' UMP biosynthetic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051414"(response to cortisol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR002082(Aspartate carbamoyltransferase, eukaryotic)|interpro:IPR002195(Dihydroorotase, conserved site)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|go:"GO:0019899"(enzyme binding)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR032466|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036901|interpro:IPR036914|mint:B2RQC6|reactome:R-MMU-500753|refseq:NP_076014.1|refseq:NP_001276451.1|dip:DIP-61412N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:t+qQw7me78vEm/Y4VBBhS8fmCsY10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8K019	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-2536273|uniprotkb:Q8C2E9|uniprotkb:Q9CSW5|uniprotkb:Q8BNZ0|ensembl:ENSMUSP00000043583	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:bclf1_mouse(display_long)|uniprotkb:Bclaf1(gene name)|psi-mi:Bclaf1(display_short)|uniprotkb:Btf(gene name synonym)|uniprotkb:Kiaa0164(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000037608(gene)|ensembl:ENSMUST00000043881(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR026668|interpro:IPR029199|mint:Q8K019|refseq:NP_001020563.1|refseq:NP_722482.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:+9NQPsUgV77P3yH9iK0ZRDIOioM10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:E9PV26	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731163|ensembl:ENSMUSP00000133114	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:e9pv26_mouse(display_long)|uniprotkb:Prr36(gene name)|psi-mi:Prr36(display_short)|uniprotkb:BC068157(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000064125(gene)|ensembl:ENSMUST00000168386(transcript)|interpro:IPR027907|refseq:NP_997086.2|refseq:XP_006508974.1|refseq:XP_006508975.1|refseq:XP_006508976.1|refseq:XP_011240389.1|refseq:XP_017168470.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:NyARVS//XbJ96x0xCkPJHFIHmYE10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9JM76	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-445042|uniprotkb:Q3TAT0|ensembl:ENSMUSP00000099584	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:arpc3_mouse(display_long)|uniprotkb:Arp2/3 complex 21 kDa subunit(gene name synonym)|uniprotkb:Arpc3(gene name)|psi-mi:Arpc3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_062798.1|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0031252"(cell leading edge)|go:"GO:0031941"(filamentous actin)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0051015"(actin filament binding)|go:"GO:0061850"(growth cone leading edge)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR007204(ARP2/3 complex, 21 kDa p21-Arc subunit)|interpro:IPR036753|mint:Q9JM76|rcsb pdb:7AQK|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-5663213|reactome:R-MMU-8856828|ensembl:ENSMUSG00000029465(gene)|ensembl:ENSMUST00000102525(transcript)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:ceYlhRcmA1dtJDhgJdjoKTwczB010090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9CVB6	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-445049|uniprotkb:Q3U870|ensembl:ENSMUSP00000006467|ensembl:ENSMUSP00000109451	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:arpc2_mouse(display_long)|uniprotkb:Arp2/3 complex 34 kDa subunit(gene name synonym)|uniprotkb:Arpc2(gene name)|psi-mi:Arpc2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_083987.1|refseq:XP_006496380.1|ensembl:ENSMUSG00000006304(gene)|ensembl:ENSMUST00000006467(transcript)|ensembl:ENSMUST00000113820(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030141"(secretory granule)|go:"GO:0030426"(growth cone)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031941"(filamentous actin)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036195"(muscle cell projection membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061825"(podosome core)|go:"GO:0061826"(podosome ring)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0061834"(actin filament branch point)|go:"GO:0061835"(ventral surface of cell)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097440"(apical dendrite)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|interpro:IPR007188(Arp2/3 complex, 34kDa subunit p34-Arc)|interpro:IPR034666|mint:Q9CVB6|rcsb pdb:7AQK|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-5663213|reactome:R-MMU-8856828|go:"GO:0010592"(positive regulation of lamellipodium assembly)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:D3LL1GEwFqIdQ6XriYDy6N1CPic10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q60875	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-772191|uniprotkb:E9QNW9|uniprotkb:O09115|uniprotkb:Q3TBI4|uniprotkb:Q3TJ16|uniprotkb:Q8CHE1|uniprotkb:Q923E0|uniprotkb:Q9ESG7|ensembl:ENSMUSP00000029694	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:arhg2_mouse(display_long)|uniprotkb:Kiaa0651(gene name synonym)|uniprotkb:Lbcl1(gene name synonym)|uniprotkb:Lfc(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Lymphoid blast crisis-like 1(gene name synonym)|uniprotkb:LBC'S first cousin(gene name synonym)|uniprotkb:Oncogene LFC(gene name synonym)|uniprotkb:Rhobin(gene name synonym)|uniprotkb:Arhgef2(gene name)|psi-mi:Arhgef2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001185840.1|refseq:NP_001185841.1|refseq:NP_001185842.1|refseq:NP_032513.3|refseq:XP_006501130.1|ensembl:ENSMUSG00000028059(gene)|ensembl:ENSMUST00000029694(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002102"(podosome)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071802"(negative regulation of podosome assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037806|interpro:IPR041020|mint:Q60875|rcsb pdb:5WI4|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:Le4PMm1AT/ManVpetNT2wBsUlok10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q68FM7	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-2365869|ensembl:ENSMUSP00000039900	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:q68fm7_mouse(display_long)|uniprotkb:Arhgef11(gene name)|psi-mi:Arhgef11(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001003912.1|ensembl:ENSMUSG00000041977(gene)|ensembl:ENSMUST00000039476(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR032919|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037803|interpro:IPR037889|interpro:IPR041020|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:HfOmxaqJCdDnhnAT3fWk9t8MPMs10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q6DFV3	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16727982|uniprotkb:A2AL67|uniprotkb:Q80TD7|uniprotkb:Q80XS1	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:rhg21_mouse(display_long)|uniprotkb:Rho GTPase-activating protein 10(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 21(gene name synonym)|uniprotkb:Arhgap21(gene name)|psi-mi:Arhgap21(display_short)|uniprotkb:Arhgap10(gene name synonym)|uniprotkb:Kiaa1424(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	interpro:IPR041489|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0051645"(Golgi localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0072384"(organelle transport along microtubule)|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-9696264|refseq:NP_001074833.3|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000198(RhoGAP)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:cfHEMUK7sE6c++73unq5fpTL6Y810090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8C8R3	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-774322|intact:EBI-2133064|uniprotkb:Q6PCN2|uniprotkb:Q3TM62|uniprotkb:Q3V2X0|uniprotkb:Q80ZZ7|uniprotkb:Q8BNC1|uniprotkb:Q8C445|uniprotkb:Q8CCV0|intact:EBI-2255612|intact:EBI-8314005|intact:MINT-4115219	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ank2_mouse(display_long)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:AnkB(gene name synonym)|uniprotkb:Ank2(gene name)|psi-mi:Ank2(display_short)|uniprotkb:Ankyrin-B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001029340.1|refseq:NP_848770.2|dip:DIP-58645N|mint:Q8C8R3|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001257"(regulation of cation channel activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:SkB13oxZVcKuMnI8r5ItFIq2pXQ10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q69ZX8	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731132|ensembl:ENSMUSP00000041243|ensembl:ENSMUSP00000125836|uniprotkb:Q52KR1|uniprotkb:Q6PAI7	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ablm3_mouse(display_long)|uniprotkb:Actin-binding LIM protein family member 3(gene name synonym)|uniprotkb:Ablim3(gene name)|psi-mi:Ablim3(display_short)|uniprotkb:Kiaa0843(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000032735(gene)|ensembl:ENSMUST00000049378(transcript)|ensembl:ENSMUST00000166783(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR003128(Villin headpiece)|interpro:IPR028449|interpro:IPR032402|interpro:IPR036886|refseq:NP_001157963.1|refseq:NP_941051.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:+EPlaNbVy2OsO4Jr+ilDhQ3b9Ds10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8K4G5	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-2307994|uniprotkb:Q80U86|uniprotkb:Q8BIR9|uniprotkb:Q8K4G3|uniprotkb:Q8K4G4	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ablm1_mouse(display_long)|uniprotkb:Ablim1(gene name)|psi-mi:Ablim1(display_short)|uniprotkb:Ablim(gene name synonym)|uniprotkb:Kiaa0059(gene name synonym)|uniprotkb:Actin-binding LIM protein family member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001096647.1|refseq:NP_848803.3|interpro:IPR003128(Villin headpiece)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_001096648.1|refseq:NP_001277742.1|refseq:NP_001277744.1|interpro:IPR032402|interpro:IPR028448|mint:Q8K4G5|interpro:IPR036886|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060271"(cilium assembly)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:UteUUoDaSxN+RrZNRUyx9jrzqHc10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:F6SEU4	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-5797569|ensembl:ENSMUSP00000141686	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q91XM9	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-400138|uniprotkb:Q8BXK7|uniprotkb:Q8BYG5|ensembl:ENSMUSP00000102814|uniprotkb:F8VQM7	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:dlg2_mouse(display_long)|uniprotkb:Dlg2(gene name)|psi-mi:Dlg2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000052572(gene)|ensembl:ENSMUST00000107196(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035759|interpro:IPR036028|interpro:IPR036034|mint:Q91XM9|rcsb pdb:2WL7|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6794361|refseq:NP_001229976.1|refseq:NP_035937.2|dip:DIP-31569N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:37/IFbjDNxh87dnN2gglIgDGyIU10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q91VM3	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-4286281|uniprotkb:A2AEV3|uniprotkb:A2AEV4|uniprotkb:Q9CVF7|uniprotkb:Q9JIG9|ensembl:ENSMUSP00000041456|ensembl:ENSMUSP00000111351|ensembl:ENSMUSP00000111353	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:wipi4_mouse(display_long)|uniprotkb:Wdr45(gene name)|psi-mi:Wdr45(display_short)|uniprotkb:DXImx38e(gene name synonym)|uniprotkb:Wdrx1(gene name synonym)|uniprotkb:Wipi4(gene name synonym)|uniprotkb:WD repeat domain X-linked 1(gene name synonym)|uniprotkb:WD repeat-containing protein 45(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_758960.1|refseq:NP_001277721.1|refseq:NP_001277723.1|refseq:NP_001277724.1|ensembl:ENSMUSG00000039382(gene)|ensembl:ENSMUST00000043045(transcript)|ensembl:ENSMUST00000115687(transcript)|ensembl:ENSMUST00000115689(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006497"(protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032910|interpro:IPR036322|reactome:R-MMU-1632852|go:"GO:0000045"(autophagosome assembly)|refseq:XP_006527719.1|refseq:XP_017174050.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:xPXqYdsOL/Y7hPJh8/uhIvSP5RA10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q0KK59	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731110|ensembl:ENSMUSP00000098659|uniprotkb:Q0KK54|uniprotkb:Q6L9U9|uniprotkb:Q8CCC5	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:unc79_mouse(display_long)|uniprotkb:Unc79(gene name)|psi-mi:Unc79(display_short)|uniprotkb:Kiaa1409(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000021198(gene)|ensembl:ENSMUST00000101099(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030534"(adult behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0048149"(behavioral response to ethanol)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024855|reactome:R-MMU-2672351|refseq:NP_001074486.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:5abOWosh1O+j/kpDW5keCvZpzXM10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:O35681	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-457995|uniprotkb:P97791|uniprotkb:Q80WV1	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:syt3_mouse(display_long)|uniprotkb:Syt3(gene name)|psi-mi:Syt3(display_short)|uniprotkb:Synaptotagmin III(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001107588.1|refseq:NP_057872.3|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR028682|mint:O35681|interpro:IPR035892	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:mkfffZn3WWGhztw/udRiKd0LUJ010090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q68FG2	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-2255511|ensembl:ENSMUSP00000008991	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:q68fg2_mouse(display_long)|uniprotkb:Sptbn2(gene name)|psi-mi:Sptbn2(display_short)|uniprotkb:Spnb3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_067262.1|refseq:XP_006531767.1|refseq:XP_006531768.1|ensembl:ENSMUSG00000067889(gene)|ensembl:ENSMUST00000008991(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008091"(spectrin)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0030534"(adult behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051693"(actin filament capping)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098918"(structural constituent of synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:0099189"(postsynaptic spectrin-associated cytoskeleton)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-MMU-2132295|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:2F7U0dl21KxXpc9Z2sk7D/wzQvM10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P70268	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-12603283|ensembl:ENSMUSP00000005616|uniprotkb:Q3UEA6|uniprotkb:Q7TST2|uniprotkb:Q8BTL8	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:pkn1_mouse(display_long)|uniprotkb:Pkn1(gene name)|psi-mi:Pkn1(display_short)|uniprotkb:Pkn(gene name synonym)|uniprotkb:Prk1(gene name synonym)|uniprotkb:Prkcl1(gene name synonym)|uniprotkb:Protein kinase C-like 1(gene name synonym)|uniprotkb:Protein kinase C-like PKN(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 1(gene name synonym)|uniprotkb:Serine-threonine protein kinase N(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000057672(gene)|ensembl:ENSMUST00000005616(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0003014"(renal system process)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035407"(histone H3-T11 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048536"(spleen development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037317|interpro:IPR037784|reactome:R-MMU-5625740|reactome:R-MMU-5625886|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|refseq:NP_001186522.1|refseq:NP_796236.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:2JXdBC4pG/j3ZEp0jfkrk1Qekso10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9JLN9	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-1571628|uniprotkb:Q811J5|uniprotkb:Q9CST1|ensembl:ENSMUSP00000099510|uniprotkb:Q2KHT0	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:mtor_mouse(display_long)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:Mtor(gene name)|psi-mi:Mtor(display_short)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:Frap1(gene name synonym)|uniprotkb:Frap(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000028991(gene)|ensembl:ENSMUST00000103221(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0007569"(cell aging)|go:"GO:0016301"(kinase activity)|go:"GO:0007584"(response to nutrient)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0007616"(long-term memory)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008361"(regulation of cell size)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0008542"(visual learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0031929"(TOR signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055006"(cardiac cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:1904058"(positive regulation of sensory perception of pain)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR036738|interpro:IPR036940|mint:Q9JLN9|reactome:R-MMU-1257604|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-3371571|reactome:R-MMU-380972|reactome:R-MMU-389357|reactome:R-MMU-5218920|reactome:R-MMU-5628897|reactome:R-MMU-6804757|reactome:R-MMU-8943724|reactome:R-MMU-9639288|refseq:NP_064393.2|dip:DIP-40570N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:Vc4KAHPBcOKi9OKdCv0vbzLaj2Y10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8K310	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-1216295|ensembl:ENSMUSP00000125761|ensembl:ENSMUSP00000158074|ensembl:ENSMUSP00000158537	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:matr3_mouse(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_034901.2|rcsb pdb:1X4F|rcsb pdb:1X4D|ensembl:ENSMUSG00000037236(gene)|ensembl:ENSMUST00000166793(transcript)|ensembl:ENSMUST00000235199(transcript)|ensembl:ENSMUST00000237744(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:Q8K310	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:AwtFbI+oRfha+mn/v3yzG6bNXYg10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q3TES0	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16725408|ensembl:ENSMUSP00000038653|uniprotkb:Q3UHP8|uniprotkb:Q80TJ8	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:iqec3_mouse(display_long)|uniprotkb:Iqsec3(gene name)|psi-mi:Iqsec3(display_short)|uniprotkb:Kiaa1110(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000040797(gene)|ensembl:ENSMUST00000046373(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050808"(synapse organization)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099629"(postsynaptic specialization of symmetric synapse)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR033742|interpro:IPR035999|go:"GO:0060077"(inhibitory synapse)|refseq:NP_001028526.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:ca8BfkMISVCn8R1jxdoGGFCJd3s10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8K3B1	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731078|ensembl:ENSMUSP00000040168|uniprotkb:Q5M7B1	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:fbsp1_mouse(display_long)|uniprotkb:F-box only protein 45(gene name synonym)|uniprotkb:Fbxo45(gene name)|psi-mi:Fbxo45(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000035764(gene)|ensembl:ENSMUST00000042732(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0021960"(anterior commissure morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060384"(innervation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035784|interpro:IPR036047|interpro:IPR043136|go:"GO:0060386"(synapse assembly involved in innervation)|go:"GO:0098793"(presynapse)|refseq:NP_775615.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:7NVV04mOJfx6uy7iXOeocaEx3yo10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q5SQX6	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P28652	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P11798	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9WTQ5	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-643771|uniprotkb:Q80SS4|uniprotkb:Q8BPK4|uniprotkb:Q99MP1|uniprotkb:Q810D4|ensembl:ENSMUSP00000035829	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:aka12_mouse(display_long)|uniprotkb:Ssecks(gene name synonym)|uniprotkb:Src-suppressed C kinase substrate(gene name synonym)|uniprotkb:Germ cell lineage protein gercelin(gene name synonym)|uniprotkb:Akap12(gene name)|psi-mi:Akap12(display_short)|uniprotkb:Gag12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_112462.1|ensembl:ENSMUSG00000038587(gene)|ensembl:ENSMUST00000045730(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061870"(positive regulation of hepatic stellate cell migration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090036"(regulation of protein kinase C signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:1900143"(positive regulation of oligodendrocyte apoptotic process)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR018459|interpro:IPR028540|mint:Q9WTQ5|reactome:R-MMU-9013405|reactome:R-MMU-9035034	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:RXRSkp9BL27+a/XTM8s7aTaXrMc10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:E9PUD6	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731480|ensembl:ENSMUSP00000047088|ensembl:ENSMUSP00000147550|ensembl:ENSMUSP00000148239	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:e9pud6_mouse(display_long)|uniprotkb:Zscan18(gene name)|psi-mi:Zscan18(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUST00000046245(transcript)|ensembl:ENSMUST00000210650(transcript)|ensembl:ENSMUST00000211392(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR038269|ensembl:ENSMUSG00000070822(gene)|refseq:NP_001017955.2|refseq:XP_006539855.1|refseq:XP_006539856.1|refseq:XP_006539857.1|refseq:XP_011248810.1|refseq:XP_017177637.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:3f9MJ95z+tFR/5DdQFo3uX3w2CU10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q80YY7	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731459|ensembl:ENSMUSP00000103038|uniprotkb:Q69Z57|uniprotkb:Q80YY8|uniprotkb:Q9CZ99	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:zn618_mouse(display_long)|uniprotkb:Znf618(gene name)|psi-mi:Znf618(display_short)|uniprotkb:Kiaa1952(gene name synonym)|uniprotkb:Zfp618(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000028358(gene)|ensembl:ENSMUST00000107415(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:SE81gddXZrjZDlts1OHDJ4aSd9M10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P63101	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q4VBE8	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-11517219|ensembl:ENSMUSP00000041049	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:wdr18_mouse(display_long)|uniprotkb:Wdr18(gene name)|psi-mi:Wdr18(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_780659.2|ensembl:ENSMUSG00000035754(gene)|ensembl:ENSMUST00000045247(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0097344"(Rix1 complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026987|interpro:IPR036322|reactome:R-MMU-6791226	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:JAl9VKznpTqXT+yyj4Z8plbWF9E10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:O88342	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-6914976|ensembl:ENSMUSP00000005234	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:wdr1_mouse(display_long)|uniprotkb:Wdr1(gene name)|psi-mi:Wdr1(display_short)|uniprotkb:Actin-interacting protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:1990266"(neutrophil migration)|interpro:IPR001680(WD40 repeat)|interpro:IPR011045(Nitrous oxide reductase, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|reactome:R-MMU-114608|ensembl:ENSMUSG00000005103(gene)|ensembl:ENSMUST00000005234(transcript)|go:"GO:0002102"(podosome)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030054"(cell junction)|go:"GO:0030220"(platelet formation)|go:"GO:0030834"(regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0040011"(locomotion)|go:"GO:0042247"(establishment of planar polarity of follicular epithelium)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043297"(apical junction assembly)|refseq:NP_035845.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:PVIlQDv8eXQrI3QBWJOjKlj/Zig10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9EPU0	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-6876715|ensembl:ENSMUSP00000075089|uniprotkb:Q3UG00|uniprotkb:Q6GYP5|uniprotkb:Q6PHQ5|uniprotkb:Q8K0N4|uniprotkb:Q99PR4	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:rent1_mouse(display_long)|uniprotkb:Upf1(gene name)|psi-mi:Upf1(display_short)|uniprotkb:Rent1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000058301(gene)|ensembl:ENSMUST00000075666(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q9EPU0|reactome:R-MMU-975956|reactome:R-MMU-975957|go:"GO:0042162"(telomeric DNA binding)|refseq:XP_006509667.1|refseq:XP_006509668.1|refseq:NP_001116301.1|refseq:NP_109605.2|dip:DIP-60114N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:rwd4XXdf5Uqjtgao/zILckKP8AM10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:A2AN08	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-4285947|uniprotkb:A2AN07|uniprotkb:A2AN09|uniprotkb:A2AN10|uniprotkb:A2AN11|uniprotkb:Q52KI4|uniprotkb:Q6PB49|uniprotkb:Q6PFC7|uniprotkb:Q80Y11|uniprotkb:Q8BGB9|uniprotkb:Q8C3E8|uniprotkb:Q8C4W5|uniprotkb:Q8C8X7|uniprotkb:Q8CGE0|uniprotkb:Q8CHF3|ensembl:ENSMUSP00000095433	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ubr4_mouse(display_long)|uniprotkb:Kiaa0462(gene name synonym)|uniprotkb:Zubr1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Ubr4(gene name)|psi-mi:Ubr4(display_short)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:p600(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001153791.1|dip:DIP-61499N|ensembl:ENSMUSG00000066036(gene)|ensembl:ENSMUST00000097822(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:A2AN08|reactome:R-MMU-6798695|reactome:R-MMU-983168|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:dTpQoZkH0+rwfrguOvzwrbPh0+Y10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8CGB3	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-9989673|uniprotkb:Q69ZG3|uniprotkb:Q7TN77|uniprotkb:Q8BJC8	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:uaca_mouse(display_long)|uniprotkb:Uaca(gene name)|psi-mi:Uaca(display_short)|uniprotkb:Kiaa1561(gene name synonym)|uniprotkb:Nuclear membrane-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	interpro:IPR030227|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR000727(Target SNARE coiled-coil region)|refseq:NP_082559.1|refseq:XP_017169098.1|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0016020"(membrane)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:0009411"(response to UV)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|reactome:R-MMU-9013407|interpro:IPR036770	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:KqGCS0tg7lkDxcadqXj4i9F2+Fc10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q91YR1	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-527441|uniprotkb:Q52L77|uniprotkb:Q80X09|uniprotkb:O09132|ensembl:ENSMUSP00000023087	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:twf1_mouse(display_long)|uniprotkb:Protein A6(gene name synonym)|uniprotkb:Twf1(gene name)|psi-mi:Twf1(display_short)|uniprotkb:Ptk9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	dip:DIP-33923N|refseq:NP_032997.3|ensembl:ENSMUSG00000022451(gene)|ensembl:ENSMUST00000023087(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005911"(cell-cell junction)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043538"(regulation of actin phosphorylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028458|interpro:IPR029006|mint:Q91YR1|rcsb pdb:1M4J|rcsb pdb:2D8B|rcsb pdb:2HD7|rcsb pdb:3DAW|rcsb pdb:6RSW|rcsb pdb:6YP9|rcsb pdb:7DS2|rcsb pdb:7DS4|rcsb pdb:7DS6|rcsb pdb:7DS8|rcsb pdb:7DSB|reactome:R-MMU-9013418	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:GgCN343v3YPfA5sIWax5s80Yjuc10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q62318	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-346909|uniprotkb:P70391|uniprotkb:Q8C283|uniprotkb:Q99PN4|ensembl:ENSMUSP00000005705	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:tif1b_mouse(display_long)|uniprotkb:Trim28(gene name)|psi-mi:Trim28(display_short)|uniprotkb:Krip1(gene name synonym)|uniprotkb:Tif1b(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:KRAB-A-interacting protein(gene name synonym)|uniprotkb:KRIP-1(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:Kap1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_035718.2|dip:DIP-31477N|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q62318|rcsb pdb:6O5K|reactome:R-MMU-212436|ensembl:ENSMUSG00000005566(gene)|ensembl:ENSMUST00000005705(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:DvGJxQNohVWs++QEAyrqe4ngcz810090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P39447	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-79508|uniprotkb:E9QK00|ensembl:ENSMUSP00000099652	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:zo1_mouse(display_long)|uniprotkb:Tjp1(gene name)|psi-mi:Tjp1(display_short)|uniprotkb:Zo1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005516"(calmodulin binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0005634"(nucleus)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0005737"(cytoplasm)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0005921"(gap junction)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045471"(response to ethanol)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0071000"(response to magnetism)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0071253"(connexin binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:0014704"(intercalated disc)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:0016020"(membrane)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035597|interpro:IPR036028|interpro:IPR036034|mint:P39447|rcsb pdb:2RRM|reactome:R-MMU-191650|reactome:R-MMU-2028269|reactome:R-MMU-351906|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|ensembl:ENSMUSG00000030516(gene)|ensembl:ENSMUST00000102592(transcript)|go:"GO:0001825"(blastocyst formation)|refseq:NP_033412.2|dip:DIP-30946N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:wvslyL15GCrtwUReZEC9DiNvPEk10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q569Z6	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-2536252|ensembl:ENSMUSP00000079722	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:tr150_mouse(display_long)|uniprotkb:Thrap3(gene name)|psi-mi:Thrap3(display_short)|uniprotkb:Trap150(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 150 kDa component(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000043962(gene)|ensembl:ENSMUST00000080919(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR026667|interpro:IPR029199|go:"GO:0008380"(RNA splicing)|refseq:XP_011238805.1|refseq:NP_666265.3|refseq:XP_006503104.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:Cb0vHuEX3Ew27z2gvfC/36tdeYE10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q3URQ0	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-6910284|ensembl:ENSMUSP00000030030|ensembl:ENSMUSP00000132498	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:tex10_mouse(display_long)|uniprotkb:Tex10(gene name)|psi-mi:Tex10(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:XP_006538018.1|refseq:XP_006538019.1|ensembl:ENSMUSG00000028345(gene)|ensembl:ENSMUST00000030030(transcript)|ensembl:ENSMUST00000164866(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0071339"(MLL1 complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR024679|interpro:IPR037947|reactome:R-MMU-6791226|refseq:NP_758508.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:iGocOH1GUrHKJQ3umzAunS1LfLY10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q80XQ2	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731423|ensembl:ENSMUSP00000024717|uniprotkb:E9PZJ9	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:tbcd5_mouse(display_long)|uniprotkb:Tbc1d5(gene name)|psi-mi:Tbc1d5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000023923(gene)|ensembl:ENSMUST00000024717(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0010008"(endosome membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030904"(retromer complex)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|go:"GO:0005829"(cytosol)|refseq:NP_001272922.1|refseq:NP_082438.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:597onEz9WPWwJUYRSeMRZ30rY7k10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9R1Q8	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-2310403|ensembl:ENSMUSP00000093762	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:tagl3_mouse(display_long)|uniprotkb:Tagln3(gene name)|psi-mi:Tagln3(display_short)|uniprotkb:Np25(gene name synonym)|uniprotkb:Neuronal protein NP25(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_062728.1|ensembl:ENSMUSG00000022658(gene)|ensembl:ENSMUST00000096057(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0043209"(myelin sheath)|interpro:IPR000557(Calponin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR029973|interpro:IPR036872|mint:Q9R1Q8	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:p1P9GP8Fiv2p/GUS5W+zqbhHVZg10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8BQ46	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-645898|ensembl:ENSMUSP00000021018	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:q8bq46_mouse(display_long)|uniprotkb:Taf15(gene name)|psi-mi:Taf15(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_081703.1|ensembl:ENSMUSG00000020680(gene)|ensembl:ENSMUST00000021018(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0046872"(metal ion binding)|go:"GO:0048255"(mRNA stabilization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034870|interpro:IPR034875|interpro:IPR035979|interpro:IPR036443|mint:Q8BQ46|reactome:R-MMU-674695|reactome:R-MMU-6804756|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-76042	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:IIxzQ1cZR0jQ0HIn6PUfdNwfuH410090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q6ZWQ0	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-11517168|uniprotkb:Q640M5|ensembl:ENSMUSP00000047697	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:syne2_mouse(display_long)|uniprotkb:Nuclear envelope spectrin repeat protein 2(gene name synonym)|uniprotkb:Nucleus and actin connecting element protein(gene name synonym)|uniprotkb:Synaptic nuclear envelope protein 2(gene name synonym)|uniprotkb:KASH domain-containing protein 2(gene name synonym)|uniprotkb:Syne2(gene name)|psi-mi:Syne2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	dip:DIP-61049N|refseq:NP_001005510.2|ensembl:ENSMUSG00000063450(gene)|ensembl:ENSMUST00000044217(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0005739"(mitochondrion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031981"(nuclear lumen)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0007097"(nuclear migration)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051642"(centrosome localization)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR012315(Klarsicht/ANC-1/syne-1 homology)|interpro:IPR018159|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|interpro:IPR030266|interpro:IPR036872|mint:Q6ZWQ0	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:dByvgsaISSaQdpGCQahK7a5mG2w10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q5SW75	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731380|ensembl:ENSMUSP00000042625|uniprotkb:B9EJ94|uniprotkb:Q3TDK8|uniprotkb:Q3TYP8|uniprotkb:Q3U2K3|uniprotkb:Q5F268|uniprotkb:Q5SW74|uniprotkb:Q69ZC3|uniprotkb:Q76I78	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ssh2_mouse(display_long)|uniprotkb:SSH-like protein 2(gene name synonym)|uniprotkb:Ssh2(gene name)|psi-mi:Ssh2(display_short)|uniprotkb:Kiaa1725(gene name synonym)|uniprotkb:Ssh2l(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000037926(gene)|ensembl:ENSMUST00000037912(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR014876(DEK C terminal)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR043587|interpro:IPR043588|refseq:NP_001278119.1|refseq:NP_808378.2|refseq:XP_006533290.1|refseq:XP_006533292.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:bCtfnKE9srplPShQJ8InLpGKbqI10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q76I79	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731329|ensembl:ENSMUSP00000124312|uniprotkb:Q3TDG3|uniprotkb:Q69ZM4|uniprotkb:Q811E5	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ssh1_mouse(display_long)|uniprotkb:SSH-like protein 1(gene name synonym)|uniprotkb:Ssh1(gene name)|psi-mi:Ssh1(display_short)|uniprotkb:Kiaa1298(gene name synonym)|uniprotkb:Ssh1l(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000042121(gene)|ensembl:ENSMUST00000159592(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0042995"(cell projection)|go:"GO:0045202"(synapse)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0098976"(excitatory chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:0032154"(cleavage furrow)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR014876(DEK C terminal)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR027233|interpro:IPR029021|interpro:IPR043587|interpro:IPR043588|refseq:NP_932777.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:X5noQ2+txeiAvGArF3BybhQV/Gg10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q62261	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P16546	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-911063|uniprotkb:A3KGU6|uniprotkb:Q8K380|uniprotkb:Q9CT05|uniprotkb:A3KGU8|ensembl:ENSMUSP00000092697	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:sptn1_mouse(display_long)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym)|uniprotkb:Spta2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	dip:DIP-37712N|ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000095083(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032437"(cuticular plate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:P16546|reactome:R-MMU-264870|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:UVB6Kv+PBlqDH3OLoGjxm5oYVPQ10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q2KN98	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-11707802|uniprotkb:Q8CHF9|ensembl:ENSMUSP00000151322	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:cytsa_mouse(display_long)|uniprotkb:Specc1l(gene name)|psi-mi:Specc1l(display_short)|uniprotkb:Cytsa(gene name synonym)|uniprotkb:Kiaa0376(gene name synonym)|uniprotkb:SPECC1-like protein(gene name synonym)|uniprotkb:Sperm antigen with calponin homology and coiled-coil domains 1-like(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001139298.1|refseq:NP_700455.3|refseq:XP_006514315.1|refseq:XP_011241891.1|interpro:IPR040166|interpro:IPR036872|ensembl:ENSMUSG00000033444(gene)|ensembl:ENSMUST00000218766(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031941"(filamentous actin)|go:"GO:0034332"(adherens junction organization)|go:"GO:0036032"(neural crest cell delamination)|go:"GO:0051301"(cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061713"(anterior neural tube closure)|interpro:IPR001715(Calponin-like actin-binding)|refseq:XP_017169616.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:RkKLF9bYPTd1OMWh1ozpZm4E13410090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q62417	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-2365368|uniprotkb:Q80TF8|uniprotkb:Q8BZI3|uniprotkb:Q8K3Y2|uniprotkb:Q921F8|uniprotkb:Q9Z0Z8|uniprotkb:Q9Z0Z9	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:srbs1_mouse(display_long)|uniprotkb:Sorbs1(gene name)|psi-mi:Sorbs1(display_short)|uniprotkb:Kiaa1296(gene name synonym)|uniprotkb:Sh3d5(gene name synonym)|uniprotkb:Ponsin(gene name synonym)|uniprotkb:c-Cbl-associated protein(gene name synonym)|uniprotkb:SH3 domain protein 5(gene name synonym)|uniprotkb:SH3P12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001030134.1|refseq:NP_001030135.1|refseq:NP_001030136.1|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|interpro:IPR035606|interpro:IPR035610|interpro:IPR035611|interpro:IPR036028|mint:Q62417|go:"GO:0001725"(stress fiber)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016600"(flotillin complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|reactome:R-MMU-445355	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:3+0ZfSkNB+9ujOF3uyXmP2ovl8A10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P97496	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-648047|uniprotkb:Q7TS80|uniprotkb:Q7TT29|ensembl:ENSMUSP00000086094	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:smrc1_mouse(display_long)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1(gene name synonym)|uniprotkb:SWI/SNF complex 155 kDa subunit(gene name synonym)|uniprotkb:BRG1-associated factor 155(gene name synonym)|uniprotkb:SWI3-related protein(gene name synonym)|uniprotkb:Smarcc1(gene name)|psi-mi:Smarcc1(display_short)|uniprotkb:Baf155(gene name synonym)|uniprotkb:Srg3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_033237.2|dip:DIP-39986N|ensembl:ENSMUSG00000032481(gene)|ensembl:ENSMUST00000088716(transcript)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006323"(DNA packaging)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007399"(nervous system development)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0030850"(prostate gland development)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000953(Chromo domain)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR007526(SWIRM)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR030087|interpro:IPR032448|interpro:IPR032450|interpro:IPR032451|interpro:IPR036388|interpro:IPR036420|mint:P97496|reactome:R-MMU-3214858|reactome:R-MMU-8939243	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:yhuZC6SRcw/jSKI2+nruFD+QqlE10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9WTX5	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-1202363|uniprotkb:Q8C5H6|ensembl:ENSMUSP00000038744|ensembl:ENSMUSP00000104700	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:skp1_mouse(display_long)|uniprotkb:Skp1(gene name)|psi-mi:Skp1(display_short)|uniprotkb:Skp1a(gene name synonym)|uniprotkb:S-phase kinase-associated protein 1A(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:p19A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_035673.3|refseq:XP_006532849.1|go:"GO:0019904"(protein domain specific binding)|ensembl:ENSMUSG00000036309(gene)|ensembl:ENSMUST00000037324(transcript)|ensembl:ENSMUST00000109072(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:Q9WTX5|reactome:R-MMU-1169091|reactome:R-MMU-1170546|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2565942|reactome:R-MMU-2871837|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-68949|reactome:R-MMU-69231|reactome:R-MMU-8854050|reactome:R-MMU-8939902|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-917937|reactome:R-MMU-9708530|reactome:R-MMU-983168|dip:DIP-38596N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:qGk720KMKAbBPguy2tmUOZsLxRQ10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:G3X9J0	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731297|ensembl:ENSMUSP00000082965|ensembl:ENSMUSP00000138171	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:si1l3_mouse(display_long)|uniprotkb:SPA-1-like protein 3(gene name synonym)|uniprotkb:Sipa1l3(gene name)|psi-mi:Sipa1l3(display_short)|uniprotkb:Spal3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000030583(gene)|ensembl:ENSMUST00000085809(transcript)|ensembl:ENSMUST00000183096(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001725"(stress fiber)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045177"(apical part of cell)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0061689"(tricellular tight junction)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021818|interpro:IPR031204|interpro:IPR035974|interpro:IPR036034|refseq:NP_001074497.1|refseq:XP_011249034.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:cP4sX/c06fodOJLywEDHIPvdKnc10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P46062	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16730373|uniprotkb:P70204	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:sipa1_mouse(display_long)|uniprotkb:GTPase-activating protein Spa-1(gene name synonym)|uniprotkb:Sipa1(gene name)|psi-mi:Sipa1(display_short)|uniprotkb:Spa-1(gene name synonym)|uniprotkb:Spa1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	reactome:R-MMU-392517|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR035974|interpro:IPR000331(Rap/ran-GAP)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:0Xo2HFTozq7tSRRov5+VuZskCpA10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q99NB9	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-688642|uniprotkb:Q9CSK5	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:sf3b1_mouse(display_long)|uniprotkb:Pre-mRNA-splicing factor SF3b 155 kDa subunit(gene name synonym)|uniprotkb:Spliceosome-associated protein 155(gene name synonym)|uniprotkb:Sf3b1(gene name)|psi-mi:Sf3b1(display_short)|uniprotkb:Sap155(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR015016(Splicing factor 3B subunit 1)|interpro:IPR038737|mint:Q99NB9|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034693"(U11/U12 snRNP)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990935"(splicing factor binding)|reactome:R-MMU-5250924|reactome:R-MMU-72163|reactome:R-MMU-72165	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:NPPPnKP4RuT43H/9MKMGIkQqZTM10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9EP97	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-15912770|ensembl:ENSMUSP00000005336|ensembl:ENSMUSP00000066581|uniprotkb:Q5F2A5|uniprotkb:Q8BRD5|uniprotkb:Q8C2H5	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:senp3_mouse(display_long)|uniprotkb:Senp3(gene name)|psi-mi:Senp3(display_short)|uniprotkb:Smt3ip(gene name synonym)|uniprotkb:Smt3ip1(gene name synonym)|uniprotkb:SUMO-1-specific protease 3(gene name synonym)|uniprotkb:Sentrin/SUMO-specific protease SENP3(gene name synonym)|uniprotkb:Smt3-specific isopeptidase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000005204(gene)|ensembl:ENSMUST00000005336(transcript)|ensembl:ENSMUST00000066760(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016926"(protein desumoylation)|go:"GO:0019538"(protein metabolic process)|go:"GO:0071339"(MLL1 complex)|interpro:IPR003653(Peptidase C48, SUMO/Sentrin/Ubl1)|interpro:IPR037945|interpro:IPR038765|reactome:R-MMU-6791226|refseq:NP_001157043.1|refseq:NP_109627.3|dip:DIP-59204N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:6okZYIai8TyPQjr0WDfIAZ4FDXM10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q3UPL0	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-6909243|ensembl:ENSMUSP00000092157|uniprotkb:Q3UYH3|uniprotkb:Q6IQZ3|uniprotkb:Q7TQJ7|uniprotkb:Q811J4	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:sc31a_mouse(display_long)|uniprotkb:Sec31a(gene name)|psi-mi:Sec31a(display_short)|uniprotkb:Sec31l1(gene name synonym)|uniprotkb:SEC31-like protein 1(gene name synonym)|uniprotkb:SEC31-related protein A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:XP_011247860.1|ensembl:ENSMUSG00000035325(gene)|ensembl:ENSMUST00000094578(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0030120"(vesicle coat)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024298|interpro:IPR036322|interpro:IPR040251|reactome:R-MMU-2132295|reactome:R-MMU-983170|reactome:R-MMU-204005|refseq:NP_081245.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:J31KA8NKdMY8qDfuuHzkvlW5SXA10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q01405	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-775901|ensembl:ENSMUSP00000021375|uniprotkb:Q8JZL4	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:sc23a_mouse(display_long)|uniprotkb:SEC23-related protein A(gene name synonym)|uniprotkb:Sec23a(gene name)|psi-mi:Sec23a(display_short)|uniprotkb:Sec23(gene name synonym)|uniprotkb:Sec23r(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000020986(gene)|ensembl:ENSMUST00000021375(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR007123(Gelsolin region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|refseq:NP_033173.2|refseq:XP_006515691.1|dip:DIP-32032N|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR037364|interpro:IPR037550|mint:Q01405|reactome:R-MMU-204005|reactome:R-MMU-2132295|reactome:R-MMU-5694530|reactome:R-MMU-983170	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:0aSRfr1sJuL/w805EjjbO4tw/Hg10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q80U72	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-1766028|uniprotkb:Q6P5H7|uniprotkb:Q7TPH8|uniprotkb:Q80VB1|uniprotkb:Q8CI48|uniprotkb:Q8VII1|uniprotkb:Q922S3|ensembl:ENSMUSP00000068056	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:scrib_mouse(display_long)|uniprotkb:Scrib(gene name)|psi-mi:Scrib(display_short)|uniprotkb:Kiaa0147(gene name synonym)|uniprotkb:Lap4(gene name synonym)|uniprotkb:Scrib1(gene name synonym)|uniprotkb:Protein LAP4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_598850.1|refseq:XP_017171844.1|refseq:NP_001297471.1|refseq:NP_001297472.1|dip:DIP-40660N|ensembl:ENSMUSG00000022568(gene)|ensembl:ENSMUST00000063747(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001843"(neural tube closure)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0008104"(protein localization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016477"(cell migration)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036034|mint:Q80U72|reactome:R-MMU-9013148|reactome:R-MMU-9013406|reactome:R-MMU-9696264|reactome:R-MMU-9696270	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:WF4b5QAjIGIgq6tnexNZtDhI7gk10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8VEE4	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-3043955|ensembl:ENSMUSP00000090585|uniprotkb:Q3TEJ8	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:rfa1_mouse(display_long)|uniprotkb:Rpa1(gene name)|psi-mi:Rpa1(display_short)|uniprotkb:Replication factor A protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000000751(gene)|ensembl:ENSMUST00000092907(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016605"(PML body)|go:"GO:0030097"(hemopoiesis)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051276"(chromosome organization)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0090734"(site of DNA damage)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|reactome:R-MMU-110312|reactome:R-MMU-110314|reactome:R-MMU-110320|reactome:R-MMU-174437|reactome:R-MMU-176187|reactome:R-MMU-3108214|reactome:R-MMU-3371453|reactome:R-MMU-5358565|reactome:R-MMU-5358606|reactome:R-MMU-5651801|reactome:R-MMU-5655862|reactome:R-MMU-5656121|reactome:R-MMU-5656169|reactome:R-MMU-5685938|reactome:R-MMU-5685942|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-5696395|reactome:R-MMU-5696397|reactome:R-MMU-5696400|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6783310|reactome:R-MMU-6804756|reactome:R-MMU-68962|reactome:R-MMU-69166|reactome:R-MMU-69473|refseq:NP_001157695.1|refseq:NP_080929.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:OMM1BI6PIp9gBtLB1XtcsIwVWR810090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q3TLH4	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-6908845|ensembl:ENSMUSP00000138433|uniprotkb:E9QKG5|uniprotkb:Q05CS4|uniprotkb:Q05DM5|uniprotkb:Q3TKF3|uniprotkb:Q3UXU5|uniprotkb:Q4FZE4|uniprotkb:Q66K03|uniprotkb:Q6P3F4|uniprotkb:Q80TK3|uniprotkb:Q80YR0|uniprotkb:Q8BMJ4|uniprotkb:Q8C1K7|uniprotkb:Q8CGH3	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:prc2c_mouse(display_long)|uniprotkb:Prrc2c(gene name)|psi-mi:Prrc2c(display_short)|uniprotkb:Bat2d(gene name synonym)|uniprotkb:Bat2d1(gene name synonym)|uniprotkb:Bat2l2(gene name synonym)|uniprotkb:Kiaa1096(gene name synonym)|uniprotkb:BAT2 domain-containing protein 1(gene name synonym)|uniprotkb:HLA-B-associated transcript 2-like 2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:XP_011237086.1|ensembl:ENSMUSG00000040225(gene)|ensembl:ENSMUST00000182660(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q3TLH4|refseq:NP_001074759.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:lJHI4KKm0yJpyg2mURs2zCXOrSY10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q76MZ3	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-400413|ensembl:ENSMUSP00000007708	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:2aaa_mouse(display_long)|uniprotkb:Ppp2r1a(gene name)|psi-mi:Ppp2r1a(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_058587.1|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:Q76MZ3|rcsb pdb:2IAE|rcsb pdb:2PF4|rcsb pdb:3FGA|rcsb pdb:6EF4|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2995383|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-975957|ensembl:ENSMUSG00000007564(gene)|ensembl:ENSMUST00000007708(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051232"(meiotic spindle elongation)|dip:DIP-29429N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:0tnO11U1SNOOT46j23f7dim8O8k10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q6R891	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-774681|uniprotkb:Q8K0X7|ensembl:ENSMUSP00000041732	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:neb2_mouse(display_long)|uniprotkb:Neurabin-II(gene name synonym)|uniprotkb:Spinophilin(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 9B(gene name synonym)|uniprotkb:Ppp1r9b(gene name)|psi-mi:Ppp1r9b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_758465.2|ensembl:ENSMUSG00000038976(gene)|ensembl:ENSMUST00000038696(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051015"(actin filament binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0061458"(reproductive system development)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097338"(response to clozapine)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903119"(protein localization to actin cytoskeleton)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904372"(positive regulation of protein localization to actin cortical patch)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904386"(response to L-phenylalanine derivative)|go:"GO:1990778"(protein localization to cell periphery)|go:"GO:1990780"(cytoplasmic side of dendritic spine plasma membrane)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR029921|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q6R891	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:UKGG1FQWWvX56wsI2kQB1jU5uOc10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9DBR7	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-1014335|uniprotkb:Q8CBV2|uniprotkb:Q99NB6|uniprotkb:Q05A74|ensembl:ENSMUSP00000151842	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:mypt1_mouse(display_long)|uniprotkb:Myosin phosphatase-targeting subunit 1(gene name synonym)|uniprotkb:Ppp1r12a(gene name)|psi-mi:Ppp1r12a(display_short)|uniprotkb:Mypt1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_082168.1|reactome:R-MMU-2565942|reactome:R-MMU-5625740|reactome:R-MMU-5627123|ensembl:ENSMUSG00000019907(gene)|ensembl:ENSMUST00000219263(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031672"(A band)|go:"GO:0035507"(regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035508"(positive regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035690"|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043292"(contractile fiber)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR020683|interpro:IPR031775|interpro:IPR036770|mint:Q9DBR7|refseq:XP_006513389.1|dip:DIP-29982N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:EI7A6KJizAxFfN09Tm2wKzIyJ7g10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P62141	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-352338|uniprotkb:P37140|uniprotkb:Q3TBE5|uniprotkb:Q3TL90|uniprotkb:Q542E7|uniprotkb:Q8C285|uniprotkb:Q9DBY2|ensembl:ENSMUSP00000015100|ensembl:ENSMUSP00000144047	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:pp1b_mouse(display_long)|uniprotkb:Ppp1cb(gene name)|psi-mi:Ppp1cb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_766295.2|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|mint:P62141|reactome:R-MMU-2565942|reactome:R-MMU-5625740|reactome:R-MMU-5627123|reactome:R-MMU-5673000|ensembl:ENSMUSG00000014956(gene)|ensembl:ENSMUST00000015100(transcript)|ensembl:ENSMUST00000201360(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:VtNJVyimeiEuRDDWtGswTqoSOH810090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P62137	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-357187|ensembl:ENSMUSP00000039109|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:Q3U7G7|uniprotkb:Q9Z1G2	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:pp1a_mouse(display_long)|uniprotkb:Ppp1ca(gene name)|psi-mi:Ppp1ca(display_short)|uniprotkb:Ppp1a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62137|rcsb pdb:5ZQV|rcsb pdb:5ZT0|reactome:R-MMU-180024|ensembl:ENSMUSG00000040385(gene)|ensembl:ENSMUST00000046094(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|refseq:NP_114074.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:kr38FkfqhN5ex5rxh4ZJbSdd8IM10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9DBD5	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-6909114|ensembl:ENSMUSP00000019065|uniprotkb:Q5F2E2|uniprotkb:Q6PEM0|uniprotkb:Q91YM9	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:pelp1_mouse(display_long)|uniprotkb:Pelp1(gene name)|psi-mi:Pelp1(display_short)|uniprotkb:Mnar(gene name synonym)|uniprotkb:Modulator of non-genomic activity of estrogen receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071391"(cellular response to estrogen stimulus)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012583(NUC201)|interpro:IPR012980(Protein of unknown function NUC202)|interpro:IPR016024(Armadillo-type fold)|mint:Q9DBD5|reactome:R-MMU-6791226|go:"GO:0035327"|ensembl:ENSMUSG00000018921(gene)|ensembl:ENSMUST00000019065(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|refseq:NP_083507.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:ekcHE9INQnzjdsJTuE6+3e1R+Fs10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9R0L6	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-4284371|uniprotkb:O70287|uniprotkb:Q3URH6|uniprotkb:Q7TMS7|uniprotkb:Q8C9V2|uniprotkb:Q91Y27|uniprotkb:Q91Y28|uniprotkb:Q91Y51|uniprotkb:Q9CRK8|uniprotkb:Q923L0|uniprotkb:Q9CT57|uniprotkb:E9QLK2|ensembl:ENSMUSP00000039709	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:pcm1_mouse(display_long)|uniprotkb:Pcm1(gene name)|psi-mi:Pcm1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_076151.2|refseq:XP_006509361.1|ensembl:ENSMUSG00000031592(gene)|ensembl:ENSMUST00000045218(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q9R0L6|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-380320	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:OT+ZOQY5pqQojMcLCWMIY+6zdl410090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P11103	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-642213|uniprotkb:Q9JLX4|uniprotkb:Q9QVQ3	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:parp1_mouse(display_long)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Parp1(gene name)|psi-mi:Parp1(display_short)|uniprotkb:Adprp(gene name synonym)|uniprotkb:Adprt(gene name synonym)|uniprotkb:Adprt1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|reactome:R-MMU-110362|reactome:R-MMU-2173795|reactome:R-MMU-3108214|reactome:R-MMU-5685939|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0034644"(cellular response to UV)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071451"(cellular response to superoxide)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903516"(regulation of single strand break repair)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1903827"|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:0070212"(protein poly-ADP-ribosylation)|mint:P11103|dip:DIP-39371N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:ZJY1aTtD8Cz198SVs9FDdUSli7s10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q3TZX8	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-6910341|ensembl:ENSMUSP00000081133|uniprotkb:A0PJC7|uniprotkb:B1AS65|uniprotkb:Q05A31|uniprotkb:Q8BQE1|uniprotkb:Q8C8L5|uniprotkb:Q8C9A8|uniprotkb:Q9D678	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:nol9_mouse(display_long)|uniprotkb:Nol9(gene name)|psi-mi:Nol9(display_short)|uniprotkb:Nucleolar protein 9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000028948(gene)|ensembl:ENSMUST00000084116(transcript)|go:"GO:0000448"("cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006396"(RNA processing)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051731"(polynucleotide 5'-hydroxyl-kinase activity)|interpro:IPR027417|interpro:IPR032319|mint:Q3TZX8|reactome:R-MMU-6791226|refseq:NP_001153071.1|refseq:NP_083003.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:+ouzQxlnqezFE6OB+EPtscf8aMg10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P97305	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731247|uniprotkb:Q60896	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:nfac3_mouse(display_long)|uniprotkb:NFATx(gene name synonym)|uniprotkb:T-cell transcription factor NFAT4(gene name synonym)|uniprotkb:Nfatc3(gene name)|psi-mi:Nfatc3(display_short)|uniprotkb:Nfat4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0014904"(myotube cell development)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048538"(thymus development)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0055001"(muscle cell development)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:0007507"(heart development)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0014902"(myotube differentiation)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR032397|interpro:IPR011539(Rel homology)|interpro:IPR037059	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:IezCOOtD6enGzpqj/P/5X9QVF+k10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q6P5H2	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-2899462|ensembl:ENSMUSP00000088493|uniprotkb:A1E2I2|uniprotkb:Q80X00|uniprotkb:Q8BPH7|uniprotkb:Q9CV43|uniprotkb:Q9R0C4	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:nest_mouse(display_long)|uniprotkb:Nes(gene name)|psi-mi:Nes(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUST00000090973(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030844"(positive regulation of intermediate filament depolymerization)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048858"(cell projection morphogenesis)|ensembl:ENSMUSG00000004891(gene)|go:"GO:0072089"(stem cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR018039|interpro:IPR031211|interpro:IPR039008|refseq:NP_057910.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:c9UQwTSScUEP6n41WzoQiEzEyN410090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8C854	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-4285350|uniprotkb:Q6ZPT3|uniprotkb:Q8QZZ1|uniprotkb:Q60690|uniprotkb:Q6P930|ensembl:ENSMUSP00000123088	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:myef2_mouse(display_long)|uniprotkb:Myef2(gene name)|psi-mi:Myef2(display_short)|uniprotkb:Kiaa1341(gene name synonym)|uniprotkb:Mef2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001155889.1|refseq:XP_006498947.1|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034630|interpro:IPR034631|interpro:IPR034632|interpro:IPR035979|interpro:IPR000504(RNA recognition motif, RNP-1)|mint:Q8C854|ensembl:ENSMUSG00000027201(gene)|ensembl:ENSMUST00000152367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|refseq:XP_017171620.1|refseq:XP_017171621.1|refseq:XP_017171623.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:ZnM8NqQUhlLdO7gzhs09ckrZUPw10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q7TPV4	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-1373622|uniprotkb:O35851|uniprotkb:Q80Y66|uniprotkb:Q8R4X2|uniprotkb:Q99KP0|ensembl:ENSMUSP00000044827	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:mbb1a_mouse(display_long)|uniprotkb:Mybbp1a(gene name)|psi-mi:Mybbp1a(display_short)|uniprotkb:P160(gene name synonym)|uniprotkb:Myb-binding protein of 160 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_058056.2|dip:DIP-39831N|ensembl:ENSMUSG00000040463(gene)|ensembl:ENSMUST00000045633(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR007015(DNA polymerase V)|interpro:IPR016024(Armadillo-type fold)|mint:Q7TPV4|reactome:R-MMU-5250924	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:rt1TQLZB7JNBkpt3DooDAlzOYCo10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P97434	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-2365654|uniprotkb:Q3TBR5|uniprotkb:Q3TC85|uniprotkb:Q3TRS0|uniprotkb:Q3U1Y8|uniprotkb:Q3U3E4|uniprotkb:Q5SWZ3|uniprotkb:Q5SWZ4|uniprotkb:Q5SWZ7|uniprotkb:Q6P559|uniprotkb:Q80YC8|ensembl:ENSMUSP00000112072	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:mprip_mouse(display_long)|uniprotkb:Mprip(gene name)|psi-mi:Mprip(display_short)|uniprotkb:Kiaa0864(gene name synonym)|uniprotkb:Mrip(gene name synonym)|uniprotkb:Rhoip3(gene name synonym)|uniprotkb:Rho-interacting protein 3(gene name synonym)|uniprotkb:p116Rip(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_036157.2|refseq:NP_957697.1|refseq:XP_006533503.1|ensembl:ENSMUSG00000005417(gene)|ensembl:ENSMUST00000116371(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0051015"(actin filament binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039597|mint:P97434	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:jwOKcVLEosfXdMVQ5LfEjkan/U410090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:A2ANY6	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-10729525|ensembl:ENSMUSP00000071569	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:a2any6_mouse(display_long)|uniprotkb:Mdn1(gene name)|psi-mi:Mdn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:XP_006537539.1|ensembl:ENSMUSG00000058006(gene)|ensembl:ENSMUST00000071642(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0045111"(intermediate filament cytoskeleton)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011704(ATPase associated with various cellular activities, AAA-5)|interpro:IPR012099(Midasin)|interpro:IPR027417|interpro:IPR029317|interpro:IPR036465|interpro:IPR040848|interpro:IPR041190	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:bn5lDptrXf2XbvZt9Br/IYoH9KY10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P97820	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-644181	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:m4k4_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase kinase 4(gene name synonym)|uniprotkb:HPK/GCK-like kinase HGK(gene name synonym)|uniprotkb:Nck-interacting kinase(gene name synonym)|uniprotkb:Map4k4(gene name)|psi-mi:Map4k4(display_short)|uniprotkb:Nik(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001239129.1|refseq:NP_001239130.1|refseq:NP_001239131.1|refseq:NP_032722.2|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-2559580|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032014"(positive regulation of ARF protein signal transduction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-40973N|mint:P97820	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:laMTX6DrOoTz4D8zxLP5ohzqKyw10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9ER67	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731218|ensembl:ENSMUSP00000026302|ensembl:ENSMUSP00000108317|ensembl:ENSMUSP00000108319|ensembl:ENSMUSP00000108320	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:q9er67_mouse(display_long)|uniprotkb:Maged2(gene name)|psi-mi:Maged2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000025268(gene)|ensembl:ENSMUST00000026302(transcript)|ensembl:ENSMUST00000112697(transcript)|ensembl:ENSMUST00000112699(transcript)|ensembl:ENSMUST00000112700(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007565"(female pregnancy)|go:"GO:0070294"(renal sodium ion absorption)|interpro:IPR002190(MAGE protein)|interpro:IPR028810|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-MMU-114608|refseq:NP_001186175.1|refseq:NP_109625.1|refseq:XP_006529060.1|refseq:XP_006529061.1|refseq:XP_006529062.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:+3Z5N6WLUNM2ed7Irzn9DAXL+AU10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9QXZ0	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-643248|intact:EBI-2658096|uniprotkb:B1ARU3|uniprotkb:Q4PLL5|uniprotkb:P97394|uniprotkb:P97395|uniprotkb:P97396	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:macf1_mouse(display_long)|uniprotkb:Actin cross-linking family 7(gene name synonym)|uniprotkb:Macf1(gene name)|psi-mi:Macf1(display_short)|uniprotkb:Acf7(gene name synonym)|uniprotkb:Aclp7(gene name synonym)|uniprotkb:Macf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR002017(Spectrin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR001101(Plectin repeat)|interpro:IPR018159|interpro:IPR001452(Src homology-3)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0008104"(protein localization)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|mint:Q9QXZ0|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:niJxpkI45VTa5x73A1tuX/aLXgo10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q3UZ39	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-2270972|uniprotkb:O70323|uniprotkb:Q3TS94|ensembl:ENSMUSP00000095254	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:lrrf1_mouse(display_long)|uniprotkb:H186 FLAP(gene name synonym)|uniprotkb:FLI-LRR-associated protein 1(gene name synonym)|uniprotkb:Lrrfip1(gene name)|psi-mi:Lrrfip1(display_short)|uniprotkb:Flap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001104781.1|refseq:NP_001104782.1|refseq:NP_032541.1|ensembl:ENSMUSG00000026305(gene)|ensembl:ENSMUST00000097649(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR019139|mint:Q3UZ39	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:LL6ZrfCorNlWgE0W5E5+LVfsqWo10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q3UMG5	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16728543|ensembl:ENSMUSP00000108438|uniprotkb:A2AMN8|uniprotkb:Q7TNP9|uniprotkb:Q80TC9	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:lrch2_mouse(display_long)|uniprotkb:Lrch2(gene name)|psi-mi:Lrch2(display_short)|uniprotkb:Kiaa1495(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000031290(gene)|ensembl:ENSMUST00000112819(transcript)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036872|refseq:NP_001074642.1|refseq:XP_006528853.2|refseq:XP_006528854.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:+sAWZHf2327czTRMaLkHBa0SSek10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P14733	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-445247|uniprotkb:Q61791|ensembl:ENSMUSP00000025486	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:lmnb1_mouse(display_long)|uniprotkb:Lmnb1(gene name)|psi-mi:Lmnb1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_034851.2|mint:P14733|reactome:R-MMU-9035034|reactome:R-MMU-2559584|reactome:R-MMU-352238|reactome:R-MMU-4419969|reactome:R-MMU-9013405|ensembl:ENSMUSG00000024590(gene)|ensembl:ENSMUST00000025486(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:1904609"(cellular response to monosodium L-glutamate)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|go:"GO:0003690"(double-stranded DNA binding)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:/Mo4KS6v6KhDRlYgD5CVVVtWVD810090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q3UH68	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16731192|ensembl:ENSMUSP00000098723|uniprotkb:Q6DIC3|uniprotkb:Q80TK1	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:limc1_mouse(display_long)|uniprotkb:Limch1(gene name)|psi-mi:Limch1(display_short)|uniprotkb:Kiaa1102(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000037736(gene)|ensembl:ENSMUST00000101164(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032034"(myosin II head/neck binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060327"(cytoplasmic actin-based contraction involved in cell motility)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001997(Calponin)|interpro:IPR029980|interpro:IPR031865|interpro:IPR036872|mint:Q3UH68|refseq:NP_001001980.2|refseq:NP_001243051.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:P8I5hZ1jOyZUpClXSiMeTpic7AQ10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9ERG0	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-2693855|uniprotkb:Q8K2H0|uniprotkb:Q9ERG1|ensembl:ENSMUSP00000073371	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:lima1_mouse(display_long)|uniprotkb:Lima1(gene name)|psi-mi:Lima1(display_short)|uniprotkb:D15Ertd366e(gene name synonym)|uniprotkb:Eplin(gene name synonym)|uniprotkb:Epithelial protein lost in neoplasm(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001107017.1|ensembl:ENSMUSG00000023022(gene)|ensembl:ENSMUST00000073691(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031526"(brush border membrane)|go:"GO:0031529"(ruffle organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR028740|mint:Q9ERG0|dip:DIP-29634N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:eP6Wwk4PGraTfIMbC1TI1Hb+MBA10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q61595	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-775369|uniprotkb:Q8BG49|uniprotkb:Q8BHF4|uniprotkb:Q8BHM8|uniprotkb:Q8C9Y5|uniprotkb:Q8CG51|uniprotkb:Q8CG52|uniprotkb:Q8CG53|uniprotkb:Q8CG54|uniprotkb:Q8CG55|uniprotkb:Q8CG56|uniprotkb:Q8CG57|uniprotkb:Q8CG58|uniprotkb:Q8CG59|uniprotkb:Q8CG60|uniprotkb:Q8CG61|uniprotkb:Q8CG62|uniprotkb:Q8CG63	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ktn1_mouse(display_long)|uniprotkb:Ktn1(gene name)|psi-mi:Ktn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_032503.2|refseq:NP_001280564.1|refseq:NP_001280565.1|interpro:IPR024854|refseq:NP_001334448.1|refseq:NP_001334449.1|refseq:NP_001334450.1|refseq:NP_001334452.1|refseq:NP_001334453.1|refseq:NP_001334454.1|refseq:NP_001334455.1|refseq:NP_001334456.1|refseq:NP_001334457.1|mint:Q61595|interpro:IPR007794(Ribosome receptor lysine or proline rich)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0015031"(protein transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|reactome:R-MMU-381426|reactome:R-MMU-5625970|reactome:R-MMU-8957275|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013408|reactome:R-MMU-9696264|reactome:R-MMU-9696270	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:xgS8/yfp5yj+gPyaC6a/gmSrxTA10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9QXL1	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-911088|uniprotkb:E9PUY6|uniprotkb:P97424	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ki21b_mouse(display_long)|uniprotkb:Kinesin-like protein KIF6(gene name synonym)|uniprotkb:Kif21b(gene name)|psi-mi:Kif21b(display_short)|uniprotkb:Kif6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001034561.1|interpro:IPR019821|interpro:IPR001752(Kinesin, motor region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR027417|interpro:IPR027640|interpro:IPR036322|interpro:IPR036961|reactome:R-MMU-6811434|reactome:R-MMU-983189|reactome:R-MMU-2132295|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:1990939"	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:p5XA5tStORNyakd6slZvbCOfPfI10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9JKF1	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-644633|ensembl:ENSMUSP00000128278|uniprotkb:G3UW45	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:iqga1_mouse(display_long)|uniprotkb:Iqgap1(gene name)|psi-mi:Iqgap1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|ensembl:ENSMUSG00000030536(gene)|ensembl:ENSMUST00000167377(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010761"(fibroblast migration)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0031252"(cell leading edge)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:Q9JKF1|reactome:R-MMU-373753|reactome:R-MMU-5626467|reactome:R-MMU-5674135|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013106|reactome:R-MMU-9013148|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-MMU-9013149|refseq:NP_057930.2|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:qjWT+er4GkLOlebk3zzRHh2Iqoo10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q7TMY8	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P38647	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-772469|uniprotkb:Q9CQ05|intact:EBI-4282065|uniprotkb:Q3TW93|uniprotkb:Q3UVN1|uniprotkb:Q3V015|intact:EBI-1635058|uniprotkb:Q7TSZ0|ensembl:ENSMUSP00000025217	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:grp75_mouse(display_long)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:p66 MOT(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:Hspa9(gene name)|psi-mi:Hspa9(display_short)|uniprotkb:Grp75(gene name synonym)|uniprotkb:Hsp74(gene name synonym)|uniprotkb:Hspa9a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_034611.2|ensembl:ENSMUSG00000024359(gene)|ensembl:ENSMUST00000025217(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P38647|reactome:R-MMU-3371453	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:HyohIe5BGD5mW3UO0OekqUKOhbU10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P62806	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-299632|ensembl:ENSMUSP00000085006|ensembl:ENSMUSP00000100029|ensembl:ENSMUSP00000100030|ensembl:ENSMUSP00000100032|ensembl:ENSMUSP00000100033|ensembl:ENSMUSP00000100036|ensembl:ENSMUSP00000100037|ensembl:ENSMUSP00000100042|ensembl:ENSMUSP00000100044|ensembl:ENSMUSP00000100048|ensembl:ENSMUSP00000100546|ensembl:ENSMUSP00000129930|ensembl:ENSMUSP00000136357|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q2M2Q5|intact:EBI-302111|uniprotkb:Q6PDS7|uniprotkb:Q811M0|uniprotkb:A0AUM5|uniprotkb:A4FUP8|uniprotkb:A4QMY0|uniprotkb:Q0VDL9|uniprotkb:Q9D0C9|uniprotkb:Q9D6Q8|uniprotkb:Q5T006	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:h4_mouse(display_long)|uniprotkb:H4c11(gene name)|psi-mi:H4c11(display_short)|uniprotkb:H4c12(gene name)|psi-mi:H4c12(display_short)|uniprotkb:H4c14(gene name)|psi-mi:H4c14(display_short)|uniprotkb:H4c2(gene name)|psi-mi:H4c2(display_short)|uniprotkb:H4c3(gene name)|psi-mi:H4c3(display_short)|uniprotkb:H4c4(gene name)|psi-mi:H4c4(display_short)|uniprotkb:H4c6(gene name)|psi-mi:H4c6(display_short)|uniprotkb:H4c8(gene name)|psi-mi:H4c8(display_short)|uniprotkb:H4c9(gene name)|psi-mi:H4c9(display_short)|uniprotkb:H4f16(gene name)|psi-mi:H4f16(display_short)|uniprotkb:Hist1h4a(gene name synonym)|uniprotkb:Hist4h4(gene name synonym)|uniprotkb:Hist1h4b(gene name synonym)|uniprotkb:Hist1h4c(gene name synonym)|uniprotkb:Hist1h4d(gene name synonym)|uniprotkb:Hist1h4f(gene name synonym)|uniprotkb:Hist1h4h(gene name synonym)|uniprotkb:Hist1h4i(gene name synonym)|uniprotkb:Hist1h4j(gene name synonym)|uniprotkb:Hist1h4k(gene name synonym)|uniprotkb:Hist2h4a(gene name synonym)|uniprotkb:Hist2h4(gene name synonym)|uniprotkb:Hist1h4m(gene name)|psi-mi:Hist1h4m(display_short)|uniprotkb:H4-53(gene name synonym)|uniprotkb:H4-12(gene name synonym)|uniprotkb:H4c1(gene name)|psi-mi:H4c1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000060093(gene)|ensembl:ENSMUSG00000060639(gene)|ensembl:ENSMUSG00000060678(gene)|ensembl:ENSMUSG00000060981(gene)|ensembl:ENSMUSG00000061482(gene)|ensembl:ENSMUSG00000064288(gene)|ensembl:ENSMUSG00000067455(gene)|ensembl:ENSMUSG00000069266(gene)|ensembl:ENSMUSG00000069274(gene)|ensembl:ENSMUSG00000069305(gene)|ensembl:ENSMUSG00000069306(gene)|ensembl:ENSMUSG00000091405(gene)|ensembl:ENSMUST00000087714(transcript)|ensembl:ENSMUST00000102964(transcript)|ensembl:ENSMUST00000102965(transcript)|ensembl:ENSMUST00000102967(transcript)|ensembl:ENSMUST00000102968(transcript)|ensembl:ENSMUST00000102971(transcript)|ensembl:ENSMUST00000102972(transcript)|ensembl:ENSMUST00000102977(transcript)|ensembl:ENSMUST00000102979(transcript)|ensembl:ENSMUST00000102983(transcript)|ensembl:ENSMUST00000104941(transcript)|ensembl:ENSMUST00000171473(transcript)|ensembl:ENSMUST00000179285(transcript)|go:"GO:0000228"(nuclear chromosome)|ensembl:ENSMUSG00000096010(gene)|go:"GO:0000786"(nucleosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|mint:P62806|rcsb pdb:1F66|rcsb pdb:1U35|rcsb pdb:2WP2|go:"GO:0003677"(DNA binding)|rcsb pdb:4AU7|rcsb pdb:4DOW|rcsb pdb:5B1L|rcsb pdb:5B1M|rcsb pdb:5XM0|rcsb pdb:5XM1|reactome:R-MMU-110331|reactome:R-MMU-212300|reactome:R-MMU-2299718|reactome:R-MMU-2559580|reactome:R-MMU-110330|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-3214842|reactome:R-MMU-3214847|reactome:R-MMU-3214858|reactome:R-MMU-427359|reactome:R-MMU-427413|reactome:R-MMU-4551638|reactome:R-MMU-5250924|reactome:R-MMU-5578749|reactome:R-MMU-5625886|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-606279|reactome:R-MMU-69473|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8936459|reactome:R-MMU-9018519|reactome:R-MMU-9670095|refseq:NP_001182350.1|refseq:NP_291074.1|refseq:NP_694813.1|refseq:NP_783583.1|refseq:NP_783585.1|refseq:NP_783586.1|refseq:NP_783587.1|refseq:NP_783588.1|refseq:NP_835499.1|refseq:NP_835500.1|refseq:NP_835515.1|refseq:NP_835582.1|refseq:NP_835583.1|dip:DIP-45837N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q4U2R1	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P70288	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-302251|uniprotkb:B2RRP3	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:hdac2_mouse(display_long)|uniprotkb:Hdac2(gene name)|psi-mi:Hdac2(display_short)|uniprotkb:Yy1bp(gene name synonym)|uniprotkb:YY1 transcription factor-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-4551638|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-9022692|reactome:R-MMU-983231|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|refseq:NP_032255.2|dip:DIP-32854N|mint:P70288	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:bGLIDKTlyhBz40NViC8calRacZ010090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P13020	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-445180|uniprotkb:Q3UPB1|uniprotkb:Q8R590|intact:EBI-4281654|ensembl:ENSMUSP00000028239	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:gels_mouse(display_long)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Brevin(gene name synonym)|uniprotkb:Gsn(gene name)|psi-mi:Gsn(display_short)|uniprotkb:Gsb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_666232.2|ensembl:ENSMUSG00000026879(gene)|ensembl:ENSMUST00000028239(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030478"(actin cap)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036313"(phosphatidylinositol 3-kinase catalytic subunit binding)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043209"(myelin sheath)|go:"GO:0045010"(actin nucleation)|go:"GO:0045159"(myosin II binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0051593"(response to folic acid)|go:"GO:0051693"(actin filament capping)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060271"(cilium assembly)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0097017"(renal protein absorption)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1903903"(regulation of establishment of T cell polarity)|go:"GO:1903906"(regulation of plasma membrane raft polarization)|go:"GO:1903909"(regulation of receptor clustering)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR030004|mint:P13020|rcsb pdb:1NPH|rcsb pdb:4CBU|rcsb pdb:4CBW|rcsb pdb:4CBX|rcsb pdb:5MVV|rcsb pdb:6I4D|rcsb pdb:6I4E|rcsb pdb:6I4F|rcsb pdb:6I4G|rcsb pdb:6I4H|rcsb pdb:6I4I|rcsb pdb:6I4J|rcsb pdb:6I4K|rcsb pdb:6I4L|rcsb pdb:6I4M|reactome:R-MMU-264870|reactome:R-MMU-6798695|dip:DIP-31941N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:vByKB6qbsPzebkkufeXoP6n0SUI10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P68040	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-296749|ensembl:ENSMUSP00000020640|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-1183965|uniprotkb:Q3THP0|uniprotkb:Q3THY7|uniprotkb:Q3TKQ0|uniprotkb:Q3TW88|uniprotkb:Q5NCC5|uniprotkb:Q5NCC6|uniprotkb:Q9CSQ0|uniprotkb:Q9ERM6	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:rack1_mouse(display_long)|uniprotkb:p205(gene name synonym)|uniprotkb:Receptor of activated protein kinase C 1(gene name synonym)|uniprotkb:12-3(gene name synonym)|uniprotkb:Gnb2-rs1(gene name synonym)|uniprotkb:Gnb2l1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Rack1(gene name)|psi-mi:Rack1(display_short)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P68040|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|go:"GO:0072344"(rescue of stalled ribosome)|ensembl:ENSMUSG00000020372(gene)|ensembl:ENSMUST00000020640(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008104"(protein localization)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0006412"(translation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044297"(cell body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|refseq:NP_032169.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P97855	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-6666067|ensembl:ENSMUSP00000018727	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:g3bp1_mouse(display_long)|uniprotkb:G3bp1(gene name)|psi-mi:G3bp1(display_short)|uniprotkb:G3bp(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym)|uniprotkb:HDH-VIII(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000018583(gene)|ensembl:ENSMUST00000018727(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:P97855|refseq:NP_038744.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:Xxq1G7S8hxbGPvterifIOxpri6U10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P56959	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-400452|ensembl:ENSMUSP00000101858	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:fus_mouse(display_long)|uniprotkb:Fus(gene name)|psi-mi:Fus(display_short)|uniprotkb:Protein pigpen(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_631888.1|ensembl:ENSMUSG00000030795(gene)|ensembl:ENSMUST00000106251(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030425"(dendrite)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P56959|reactome:R-MMU-72163	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:Vwv/0vlM50l49XaUOHCtEWt/b2A10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P35922	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-645094	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q61545	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-1606991|uniprotkb:Q9D2P0|ensembl:ENSMUSP00000078867	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ews_mouse(display_long)|uniprotkb:Ewsr1(gene name)|psi-mi:Ewsr1(display_short)|uniprotkb:Ews(gene name synonym)|uniprotkb:Ewsh(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_031994.2|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033109|interpro:IPR034869|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:Q61545|ensembl:ENSMUSG00000009079(gene)|ensembl:ENSMUST00000079949(transcript)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:bvajg+ZT71/K+6hwdHFdOewgvrw10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P70372	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-6877056|ensembl:ENSMUSP00000096549|ensembl:ENSMUSP00000146866|uniprotkb:Q60745|uniprotkb:Q78QY3	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:elav1_mouse(display_long)|uniprotkb:Elavl1(gene name)|psi-mi:Elavl1(display_short)|uniprotkb:Elra(gene name synonym)|uniprotkb:Hua(gene name synonym)|uniprotkb:Elav-like generic protein(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym)|uniprotkb:MelG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000040028(gene)|ensembl:ENSMUST00000098950(transcript)|ensembl:ENSMUST00000209010(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:P70372|reactome:R-MMU-450520|reactome:R-MMU-72163|go:"GO:0019901"(protein kinase binding)|refseq:XP_006508761.1|refseq:NP_034615.2|dip:DIP-46480N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:iKHrpZqi5b7EFLkfVJSRTpi9sj010090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P60843	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-6665935|ensembl:ENSMUSP00000127034|uniprotkb:P04765|uniprotkb:Q61516	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:if4a1_mouse(display_long)|uniprotkb:Eif4a1(gene name)|psi-mi:Eif4a1(display_short)|uniprotkb:Ddx2a(gene name synonym)|uniprotkb:Eif4a(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000059796(gene)|ensembl:ENSMUST00000163666(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044728|mint:P60843|rcsb pdb:6XKI|reactome:R-MMU-1169408|reactome:R-MMU-156827|reactome:R-MMU-429947|reactome:R-MMU-72649|reactome:R-MMU-72662|reactome:R-MMU-72702|reactome:R-MMU-72706|refseq:NP_659207.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:e+2gp47oHrpxFbrBFSM4qTf3r7E10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9D8Y0	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-2694004|uniprotkb:Q9D0P4	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:efhd2_mouse(display_long)|uniprotkb:Efhd2(gene name)|psi-mi:Efhd2(display_short)|uniprotkb:Sws1(gene name synonym)|uniprotkb:Swiprosin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	interpro:IPR011992(EF-Hand type)|interpro:IPR002048(Calcium-binding EF-hand)|reactome:R-MMU-9013405|interpro:IPR040365|go:"GO:0005509"(calcium ion binding)|go:"GO:0045121"(membrane raft)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:vr6DjwFcdfiyAcFdthG6Vn2q08I10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P58252	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-773856|uniprotkb:Q544E4|ensembl:ENSMUSP00000046101	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ef2_mouse(display_long)|uniprotkb:Eef2(gene name)|psi-mi:Eef2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_031933.1|ensembl:ENSMUSG00000034994(gene)|ensembl:ENSMUST00000047864(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P58252|reactome:R-MMU-156902|reactome:R-MMU-5358493|reactome:R-MMU-6798695	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:910/vo3IRjcncyPD4f43dPtS83o10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9JHU4	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-645061|uniprotkb:E9QM71|ensembl:ENSMUSP00000018851	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:dyhc1_mouse(display_long)|uniprotkb:Dhc1(gene name synonym)|uniprotkb:Dyhc(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:Dync1h1(gene name)|psi-mi:Dync1h1(display_short)|uniprotkb:Dnch1(gene name synonym)|uniprotkb:Dnchc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_084514.2|ensembl:ENSMUSG00000018707(gene)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002177"(manchette)|go:"GO:0003341"(cilium movement)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|ensembl:ENSMUST00000018851(transcript)|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|interpro:IPR042219|mint:Q9JHU4|rcsb pdb:3ERR|rcsb pdb:3J1T|rcsb pdb:3J1U|rcsb pdb:3WUQ|rcsb pdb:5AYH|rcsb pdb:6RZA|rcsb pdb:6RZB|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:sbED0xqQpe32T7I8ijeS3Xqlx7010090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q91ZU6	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-446159|uniprotkb:Q60845|uniprotkb:Q9WU50|uniprotkb:Q1KP04|uniprotkb:Q3I6J6|uniprotkb:Q8K5D4|uniprotkb:Q91ZU7|uniprotkb:Q91ZU8|uniprotkb:Q60824|uniprotkb:E9PXE5|uniprotkb:E9QL23|uniprotkb:S4R1U5|ensembl:ENSMUSP00000095392	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:dyst_mouse(display_long)|uniprotkb:Dystonia musculorum protein(gene name synonym)|uniprotkb:Hemidesmosomal plaque protein(gene name synonym)|uniprotkb:Dst(gene name)|psi-mi:Dst(display_short)|uniprotkb:Bpag1(gene name synonym)|uniprotkb:Macf2(gene name synonym)|uniprotkb:Microtubule actin cross-linking factor 2(gene name synonym)|uniprotkb:Bullous pemphigoid antigen 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_034211.2|refseq:NP_598594.2|refseq:NP_604443.2|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031673"(H zone)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042060"(wound healing)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0046907"(intracellular transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR011992(EF-Hand type)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:Q91ZU6|rcsb pdb:2IAK|reactome:R-MMU-446107|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-9696264|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000026131(gene)|ensembl:ENSMUST00000097785(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014069"(postsynaptic density)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:kQkueAqyWyioKh0Hf1vVtIaHRY810090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8R1A4	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-776274|uniprotkb:Q45V78|uniprotkb:Q5PRE6|uniprotkb:Q6PJ17|uniprotkb:Q9CSB6|uniprotkb:Q9CXM7	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:dock7_mouse(display_long)|uniprotkb:Gm430(gene name synonym)|uniprotkb:Dock7(gene name)|psi-mi:Dock7(display_short)|uniprotkb:Kiaa1771(gene name synonym)|uniprotkb:Mnlt(gene name synonym)|uniprotkb:Protein moonlight(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	interpro:IPR027357|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR043162|interpro:IPR043161|interpro:IPR026791|interpro:IPR027007|interpro:IPR035892|interpro:IPR037808|mint:Q8R1A4|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043473"(pigmentation)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|reactome:R-MMU-8875555|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-983231	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:T4W30iJF8XaTuK57c9vlJFr9gpg10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q62167	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-773173|uniprotkb:O09060|uniprotkb:O09143|ensembl:ENSMUSP00000000804	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:ddx3x_mouse(display_long)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD3(gene name synonym)|uniprotkb:Embryonic RNA helicase(gene name synonym)|uniprotkb:D1Pas1-related sequence 2(gene name synonym)|uniprotkb:Ddx3x(gene name)|psi-mi:Ddx3x(display_short)|uniprotkb:D1Pas1-rs2(gene name synonym)|uniprotkb:Ddx3(gene name synonym)|uniprotkb:Dead3(gene name synonym)|uniprotkb:Erh(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_034158.1|ensembl:ENSMUSG00000000787(gene)|ensembl:ENSMUST00000000804(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q62167|reactome:R-MMU-6798695	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:K7PtRsPpXHni4TU8uzOsr6QaVxA10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:O88809	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-16724620|ensembl:ENSMUSP00000033642|ensembl:ENSMUSP00000084570|uniprotkb:Q6E5A4	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:dcx_mouse(display_long)|uniprotkb:Doublin(gene name synonym)|uniprotkb:Lissencephalin-X(gene name synonym)|uniprotkb:Dcx(gene name)|psi-mi:Dcx(display_short)|uniprotkb:Dcn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	ensembl:ENSMUSG00000031285(gene)|ensembl:ENSMUST00000033642(transcript)|ensembl:ENSMUST00000087313(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0035082"(axoneme assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060041"(retina development in camera-type eye)|interpro:IPR003533(Doublecortin)|interpro:IPR017302(Neuronal migration protein doublecortin)|interpro:IPR036572|interpro:IPR040163|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|refseq:NP_001103692.1|refseq:NP_001103693.1|refseq:NP_001103694.1|refseq:NP_034155.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:bZVdhkO518ZmQJpBRfIqaTPon1Y10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:O08788	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-776180|uniprotkb:E9QLJ1|uniprotkb:Q3TZG7|ensembl:ENSMUSP00000109552	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:dctn1_mouse(display_long)|uniprotkb:150 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:DAP-150(gene name synonym)|uniprotkb:p150-glued(gene name synonym)|uniprotkb:Dctn1(gene name)|psi-mi:Dctn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_031861.2|dip:DIP-32057N|ensembl:ENSMUSG00000031865(gene)|ensembl:ENSMUST00000113919(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005938"(cell cortex)|go:"GO:0007097"(nuclear migration)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032402"(melanosome transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045171"(intercellular bridge)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061744"(motor behavior)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0099738"(cell cortex region)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1904398"(positive regulation of neuromuscular junction development)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR022157|interpro:IPR036859|mint:O08788|reactome:R-MMU-2132295|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-8854518	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:pqj7TtNDgexEbxqLwksW3eW41bo10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9JLM8	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-771719|uniprotkb:Q6P207|ensembl:ENSMUSP00000050034	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:dclk1_mouse(display_long)|uniprotkb:Doublecortin-like and CAM kinase-like 1(gene name synonym)|uniprotkb:Dclk1(gene name)|psi-mi:Dclk1(display_short)|uniprotkb:Dclk(gene name synonym)|uniprotkb:Dcamkl1(gene name synonym)|uniprotkb:Doublecortin-like kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_064362.1|ensembl:ENSMUSG00000027797(gene)|ensembl:ENSMUST00000054237(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0009615"(response to virus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030900"(forebrain development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003533(Doublecortin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036572|mint:Q9JLM8	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:P3ZZ2GyKcdMimAcekZ8OlLbuciM10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9QXS6	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-445208|uniprotkb:A2CG16|uniprotkb:Q3V234|uniprotkb:Q922X1|uniprotkb:Q9QXS5|ensembl:ENSMUSP00000021950	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:dreb_mouse(display_long)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:Dbn1(gene name)|psi-mi:Dbn1(display_short)|uniprotkb:Drba(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001170842.1|refseq:NP_001170843.1|refseq:NP_062787.2|ensembl:ENSMUSG00000034675(gene)|ensembl:ENSMUST00000021950(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0005856"(cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048699"(generation of neurons)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0098828"(modulation of inhibitory postsynaptic potential)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:1904113"(negative regulation of muscle filament sliding)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q9QXS6|reactome:R-MMU-9013405|reactome:R-MMU-9013407|reactome:R-MMU-9013418|reactome:R-MMU-9013422	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:ArZUGZNIUfSwoIketPcPCXlSM8410090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q80YE7	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-2584874|uniprotkb:Q80YE6|uniprotkb:Q8R341|uniprotkb:Q8VDN6|uniprotkb:Q9CSD4|uniprotkb:Q9JJP7|ensembl:ENSMUSP00000153607	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:dapk1_mouse(display_long)|uniprotkb:Dapk1(gene name)|psi-mi:Dapk1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001272846.1|refseq:NP_598823.1|refseq:NP_083929.2|ensembl:ENSMUSG00000021559(gene)|ensembl:ENSMUST00000226059(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0106311"|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:0015629"(actin cytoskeleton)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR002110(Ankyrin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020676|interpro:IPR020683|interpro:IPR020859|interpro:IPR027417|interpro:IPR036770|refseq:XP_006517433.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:oKCvUwiJAHPnC07vj6M/X8D0xkQ10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q60598	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8BK63	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-771679|uniprotkb:Q64506|uniprotkb:Q80XI2|uniprotkb:Q99LY3|uniprotkb:Q3UIL0|ensembl:ENSMUSP00000132083	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:kc1a_mouse(display_long)|uniprotkb:CK1(gene name synonym)|uniprotkb:Csnk1a1(gene name)|psi-mi:Csnk1a1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:XP_006526451.1|dip:DIP-32408N|ensembl:ENSMUSG00000024576(gene)|ensembl:ENSMUST00000165721(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000776"(kinetochore)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042277"(peptide binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q8BK63|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-4641262|reactome:R-MMU-5610785|reactome:R-MMU-5635838	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:2rG1/sMVnsRKUEWsLhLAyHvqPnY10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q9WUM3	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-4284726|uniprotkb:Q9CVA2|uniprotkb:Q3UEB1|ensembl:ENSMUSP00000008893	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:cor1b_mouse(display_long)|uniprotkb:Coro1b(gene name)|psi-mi:Coro1b(display_short)|uniprotkb:Coronin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_035908.1|refseq:XP_006531804.1|refseq:XP_006531805.1|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090135"(actin filament branching)|go:"GO:1902463"(protein localization to cell leading edge)|go:"GO:2000393"(negative regulation of lamellipodium morphogenesis)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027340|interpro:IPR036322|mint:Q9WUM3|go:"GO:0051015"(actin filament binding)|ensembl:ENSMUSG00000024835(gene)|ensembl:ENSMUST00000008893(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007015"(actin filament organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031529"(ruffle organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:8f/wAw9SFege6L8WkRGpdE73+EE10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q8BRT1	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-776004|uniprotkb:Q8CHE3|uniprotkb:Q99JI3|uniprotkb:Q9DB80	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:clap2_mouse(display_long)|uniprotkb:Cytoplasmic linker-associated protein 2(gene name synonym)|uniprotkb:Clasp2(gene name)|psi-mi:Clasp2(display_short)|uniprotkb:Kiaa0627(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001273528.1|refseq:NP_001273529.1|refseq:NP_001273530.1|refseq:NP_001273531.1|refseq:NP_001273532.1|mint:Q8BRT1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024395|interpro:IPR034085|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006903"(vesicle targeting)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045180"(basal cortex)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903754"(cortical microtubule plus-end)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|rcsb pdb:3WOZ|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:ACnxijHc8A5KYqR4CDmSg2U5OYk10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:Q80TV8	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-908322|uniprotkb:Q505G6|uniprotkb:Q6DI75|uniprotkb:Q6PG14|uniprotkb:Q8BNS4|uniprotkb:Q99JH5|uniprotkb:Q99JI2|uniprotkb:Q9CVU1	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:clap1_mouse(display_long)|uniprotkb:Clasp1(gene name)|psi-mi:Clasp1(display_short)|uniprotkb:Cytoplasmic linker-associated protein 1(gene name synonym)|uniprotkb:Kiaa0622(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_001280229.1|refseq:NP_001280230.1|refseq:NP_083985.2|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024395|interpro:IPR021133|interpro:IPR028399|interpro:IPR034085|mint:Q80TV8|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0006903"(vesicle targeting)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0030981"(cortical microtubule cytoskeleton)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031592"(centrosomal corona)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0043515"(kinetochore binding)|go:"GO:0045180"(basal cortex)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-2500257	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:HwJCOu/w9CSWzqLB7WEjrC4a3bg10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7TPH6	uniprotkb:P80315	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	intact:EBI-772370|ensembl:ENSMUSP00000133523	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:tcpd_mouse(display_long)|uniprotkb:CCT-delta(gene name synonym)|uniprotkb:A45(gene name synonym)|uniprotkb:Cct4(gene name)|psi-mi:Cct4(display_short)|uniprotkb:Cctd(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731507|imex:IM-26285-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	refseq:NP_033967.1|ensembl:ENSMUSG00000007739(gene)|ensembl:ENSMUST00000173867(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042470"(melanosome)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P80315|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6814122	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/07/05	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rogid:/40BY5vhE/fuloWu9L2k7ujy9Nc10090	rigid:oymwfk9qt0cFj3lD65qJf921IQk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:P83510	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	-	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:Q8R5H6	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-774719|uniprotkb:Q91W51|uniprotkb:Q9ERQ9|ensembl:ENSMUSP00000019975|ensembl:ENSMUSP00000101148	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:wasf1_mouse(display_long)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Wasf1(gene name)|psi-mi:Wasf1(display_short)|uniprotkb:Wave1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_114083.1|refseq:XP_006512995.1|ensembl:ENSMUSG00000019831(gene)|ensembl:ENSMUST00000019975(transcript)|ensembl:ENSMUST00000105509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8R5H6|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:t+4F2ap7lNjE/AGuIwMhel4YknU10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:Q9EP53	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:Q8CC35	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-774691|uniprotkb:Q99JI0|ensembl:ENSMUSP00000125272	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:synpo_mouse(display_long)|uniprotkb:Synpo(gene name)|psi-mi:Synpo(display_short)|uniprotkb:Kiaa1029(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	ensembl:ENSMUSG00000043079(gene)|ensembl:ENSMUST00000143275(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0097444"(spine apparatus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098886"(modification of dendritic spine)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099588"(positive regulation of postsynaptic cytosolic calcium concentration)|go:"GO:1905355"(spine apparatus assembly)|interpro:IPR028753	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:X85lScd6IVk7dALEA55e9/YC9Rw10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:Q68FG2	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-2255511|ensembl:ENSMUSP00000008991	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:q68fg2_mouse(display_long)|uniprotkb:Sptbn2(gene name)|psi-mi:Sptbn2(display_short)|uniprotkb:Spnb3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_067262.1|refseq:XP_006531767.1|refseq:XP_006531768.1|ensembl:ENSMUSG00000067889(gene)|ensembl:ENSMUST00000008991(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008091"(spectrin)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0030534"(adult behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051693"(actin filament capping)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098918"(structural constituent of synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:0099189"(postsynaptic spectrin-associated cytoskeleton)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-MMU-2132295|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:2F7U0dl21KxXpc9Z2sk7D/wzQvM10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:Q62261	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:P16546	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-911063|uniprotkb:A3KGU6|uniprotkb:Q8K380|uniprotkb:Q9CT05|uniprotkb:A3KGU8|ensembl:ENSMUSP00000092697	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:sptn1_mouse(display_long)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym)|uniprotkb:Spta2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	dip:DIP-37712N|ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000095083(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032437"(cuticular plate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:P16546|reactome:R-MMU-264870|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:UVB6Kv+PBlqDH3OLoGjxm5oYVPQ10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:Q8VD37	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-776269|uniprotkb:A7BFW0|uniprotkb:Q3UFU3|uniprotkb:Q3UGA0|uniprotkb:Q8BXX4|uniprotkb:Q8C034|uniprotkb:Q9CXT2|ensembl:ENSMUSP00000079553	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:sgip1_mouse(display_long)|uniprotkb:Endophilin-3-interacting protein(gene name synonym)|uniprotkb:Sgip1(gene name)|psi-mi:Sgip1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_659155.1|refseq:NP_001272788.1|refseq:NP_001272789.1|refseq:NP_001272791.1|refseq:XP_006503491.1|refseq:XP_017175890.1|ensembl:ENSMUSG00000028524(gene)|ensembl:ENSMUST00000080728(transcript)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098793"(presynapse)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR018808|interpro:IPR028565|interpro:IPR036168|interpro:IPR037984|mint:Q8VD37|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:5TUgNAM4+5qY6EfbMvqhjc/i3/U10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:P63001	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:P08553	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-445188|uniprotkb:A2VCT5|uniprotkb:Q0VDM8|uniprotkb:Q3HRJ6|uniprotkb:Q3TNS4|uniprotkb:Q3TPK2|uniprotkb:Q61961|uniprotkb:Q8BQ20	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:nfm_mouse(display_long)|uniprotkb:Neurofilament triplet M protein(gene name synonym)|uniprotkb:160 kDa neurofilament protein(gene name synonym)|uniprotkb:Neurofilament 3(gene name synonym)|uniprotkb:Nefm(gene name)|psi-mi:Nefm(display_short)|uniprotkb:Nef3(gene name synonym)|uniprotkb:Nfm(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_032717.2|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR002957(Keratin, type I)|interpro:IPR039008|interpro:IPR027697|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030424"(axon)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|mint:P08553	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:2HBUZIEhbbrfamAhbq7gyuRUaTk10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:P08551	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-445199|uniprotkb:Q8K0Z0|ensembl:ENSMUSP00000022639	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:nfl_mouse(display_long)|uniprotkb:Neurofilament triplet L protein(gene name synonym)|uniprotkb:68 kDa neurofilament protein(gene name synonym)|uniprotkb:Nefl(gene name)|psi-mi:Nefl(display_short)|uniprotkb:Nfl(gene name synonym)|uniprotkb:Nf68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_035040.1|ensembl:ENSMUSG00000022055(gene)|ensembl:ENSMUST00000022639(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027692|interpro:IPR039008|mint:P08551|reactome:R-MMU-438066|reactome:R-MMU-5673001|go:"GO:0098981"(cholinergic synapse)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0040011"(locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051258"(protein polymerization)|go:"GO:0051412"(response to corticosterone)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060074"(synapse maturation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|dip:DIP-31944N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:E8KK2ppZXyLXIlFZp/pjXv7GBEU10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:Q9WV60	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-400793|ensembl:ENSMUSP00000023507	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:gsk3b_mouse(display_long)|uniprotkb:Gsk3b(gene name)|psi-mi:Gsk3b(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_062801.1|dip:DIP-32446N|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006983"(ER overload response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014043"(negative regulation of neuron maturation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034452"(dynactin binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:Q9WV60|rcsb pdb:4NU1|rcsb pdb:5AIR|rcsb pdb:6AE3|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3371453|reactome:R-MMU-399956|reactome:R-MMU-4641262|reactome:R-MMU-5250924|reactome:R-MMU-5610785|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046849"(bone remodeling)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0106027"(neuron projection organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904780"(negative regulation of protein localization to centrosome)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|ensembl:ENSMUSG00000022812(gene)|ensembl:ENSMUST00000023507(transcript)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:FKe0WkOBBYU0vIJLmcFNMJ+KVHA10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:P35922	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-645094	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:Q9WV92	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-911885|uniprotkb:Q69ZT8|ensembl:ENSMUSP00000079098|uniprotkb:Q9R102	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:e41l3_mouse(display_long)|uniprotkb:4.1B(gene name synonym)|uniprotkb:Differentially expressed in adenocarcinoma of the lung protein 1(gene name synonym)|uniprotkb:Epb41l3(gene name)|psi-mi:Epb41l3(display_short)|uniprotkb:Dal1(gene name synonym)|uniprotkb:Epb4.1l3(gene name synonym)|uniprotkb:Kiaa0987(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	ensembl:ENSMUSG00000024044(gene)|ensembl:ENSMUST00000080208(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043217"(myelin maintenance)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030691|interpro:IPR035963|mint:Q9WV92|reactome:R-MMU-6794361|refseq:NP_038841.1|refseq:XP_011244586.1|refseq:XP_011244591.1|refseq:XP_017172724.1|refseq:XP_017172725.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:51gkxiswTUqQbAUqjGoPthWD7jM10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:Q9Z2H5	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-774482|uniprotkb:Q3U3L1|uniprotkb:Q3UHP7|uniprotkb:Q80U34|uniprotkb:Q8K204	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:e41l1_mouse(display_long)|uniprotkb:Neuronal protein 4.1(gene name synonym)|uniprotkb:Epb41l1(gene name)|psi-mi:Epb41l1(display_short)|uniprotkb:Epb4(gene name synonym)|uniprotkb:Epb4.1l1(gene name synonym)|uniprotkb:Kiaa0338(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_001278049.1|refseq:NP_001278051.1|refseq:NP_001278052.1|refseq:NP_001006665.1|refseq:NP_038538.1|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR019749|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019747|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR018979|interpro:IPR018980|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR007477(SAB)|interpro:IPR029071|interpro:IPR035963|mint:Q9Z2H5|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0097060"(synaptic membrane)|reactome:R-MMU-399719|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:Lu31NnWhI356njHUtKbBlaO6nWE10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:O08553	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-446064|uniprotkb:Q6P5D0|ensembl:ENSMUSP00000022629	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:dpyl2_mouse(display_long)|uniprotkb:Unc-33-like phosphoprotein 2(gene name synonym)|uniprotkb:Dpysl2(gene name)|psi-mi:Dpysl2(display_short)|uniprotkb:Crmp2(gene name synonym)|uniprotkb:Ulip2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_034085.2|ensembl:ENSMUSG00000022048(gene)|ensembl:ENSMUST00000022629(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043209"(myelin sheath)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098793"(presynapse)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030615|interpro:IPR032466|mint:O08553|rcsb pdb:5UQC|reactome:R-MMU-399956|reactome:R-MMU-437239	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:97yc8TNEPMcGtGNRLvl+KV+DYr010090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:P39053	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-397785|ensembl:ENSMUSP00000122679|uniprotkb:A2AN50|uniprotkb:A2AN51|uniprotkb:A2AN54|uniprotkb:A2AN55|uniprotkb:Q3UNM1|uniprotkb:Q5DTN7|uniprotkb:Q61358|uniprotkb:Q61359|uniprotkb:Q61360|uniprotkb:Q6PDM5|uniprotkb:Q8JZZ4|uniprotkb:Q9CSY7|uniprotkb:Q9QXX1	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:dyn1_mouse(display_long)|uniprotkb:Dnm1(gene name)|psi-mi:Dnm1(display_short)|uniprotkb:Dnm(gene name synonym)|uniprotkb:Kiaa4093(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_034195.2|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:P39053|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|ensembl:ENSMUSG00000026825(gene)|ensembl:ENSMUST00000139624(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904645"(response to amyloid-beta)|refseq:NP_001288666.1|refseq:XP_006497721.2|refseq:XP_006497722.2|refseq:XP_006497723.2|refseq:XP_006497724.2|refseq:XP_006497718.2|refseq:XP_017170817.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:wtPz3gwyxU6tAgh5091LQpt099I10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:Q5SQX6	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:Q7TMB8	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:P11798	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:Q8BKX1	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:P17426	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-775189|ensembl:ENSMUSP00000082519|ensembl:ENSMUSP00000127842	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:ap2a1_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Ap2a1(gene name)|psi-mi:Ap2a1(display_short)|uniprotkb:Adtaa(gene name synonym)|uniprotkb:Clapa1(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_001070732.1|refseq:NP_031484.1|ensembl:ENSMUSG00000060279(gene)|ensembl:ENSMUST00000085399(transcript)|ensembl:ENSMUST00000166972(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0032433"(filopodium tip)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:P17426|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:Dd6Q+Et/LTlmo5qpro2Zaeq0dMc10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:P62484	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-15791842|ensembl:ENSMUSP00000058754|uniprotkb:Q6PHU3	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:abi2_mouse(display_long)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:Abi2(gene name)|psi-mi:Abi2(display_short)|uniprotkb:Abelson interactor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	ensembl:ENSMUSG00000026782(gene)|ensembl:ENSMUST00000052332(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007611"(learning or memory)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_001185499.1|refseq:NP_001185500.1|refseq:NP_937760.1|dip:DIP-48418N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:A5p3uqPuid61N78yiLHbnxA64mQ10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28660	uniprotkb:Q8CBW3	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16731934|imex:IM-26285-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	rigid:9+EwDMrQ4p3zvY+bZSg9mTyeZ+k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q8CJG0	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q920I9	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-776403|uniprotkb:Q059Q1|uniprotkb:Q3U440|uniprotkb:Q80TY3|uniprotkb:Q920J0|ensembl:ENSMUSP00000072509	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:wdr7_mouse(display_long)|uniprotkb:TGF-beta resistance-associated protein TRAG(gene name synonym)|uniprotkb:Wdr7(gene name)|psi-mi:Wdr7(display_short)|uniprotkb:Kiaa0541(gene name synonym)|uniprotkb:Trag(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_001014981.1|refseq:XP_006525540.1|ensembl:ENSMUSG00000040560(gene)|ensembl:ENSMUST00000072726(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0008021"(synaptic vesicle)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:Q920I9	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:FH0Q4cn/bo3L5bGOYYViTG2l7eE10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q4KUS2	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-775397|uniprotkb:E9QKH9|uniprotkb:Q3UHG2|ensembl:ENSMUSP00000030170	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:un13a_mouse(display_long)|uniprotkb:Munc13-1(gene name synonym)|uniprotkb:Unc13a(gene name)|psi-mi:Unc13a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_001025044.2|ensembl:ENSMUSG00000034799(gene)|ensembl:ENSMUST00000030170(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030507"(spectrin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0061789"(dense core granule priming)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099011"(neuronal dense core vesicle exocytosis)|go:"GO:0099525"(presynaptic dense core vesicle exocytosis)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR010439(Protein of unknown function DUF1041)|interpro:IPR014770(Munc13 homology 1)|interpro:IPR014772(Munc13 homology 2)|interpro:IPR019558|interpro:IPR027080|interpro:IPR027082|interpro:IPR035892|interpro:IPR037302	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:B5Qv8BCg48XDED/99G5RS7g5Fn410090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q8BYI9	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-774167|uniprotkb:A2RT70|uniprotkb:O88717|ensembl:ENSMUSP00000107298|ensembl:ENSMUSP00000141553	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:tenr_mouse(display_long)|uniprotkb:Restrictin(gene name synonym)|uniprotkb:Janusin(gene name synonym)|uniprotkb:Neural recognition molecule J1-160/180(gene name synonym)|uniprotkb:Tnr(gene name)|psi-mi:Tnr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_071707.2|refseq:XP_006496805.1|refseq:XP_006496806.1|refseq:XP_006496807.1|ensembl:ENSMUSG00000015829(gene)|ensembl:ENSMUST00000111669(transcript)|ensembl:ENSMUST00000192069(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0045121"(membrane raft)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048692"(negative regulation of axon extension involved in regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072534"(perineuronal net)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098966"(perisynaptic extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR033079|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:Q8BYI9|reactome:R-MMU-3000178	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:K7s7yPGS4RvIe+thCkAZIFGjNRA10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:A2A690	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-16733043|ensembl:ENSMUSP00000097904|uniprotkb:A2A683|uniprotkb:Q3TRZ3|uniprotkb:Q5EBP6|uniprotkb:Q69ZQ7	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:tanc2_mouse(display_long)|uniprotkb:Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:Tanc2(gene name)|psi-mi:Tanc2(display_short)|uniprotkb:Kiaa1148(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	ensembl:ENSMUSG00000053580(gene)|ensembl:ENSMUST00000100330(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0030424"(axon)|go:"GO:0043197"(dendritic spine)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099519"(dense core granule cytoskeletal transport)|interpro:IPR002110(Ankyrin)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:A2A690|refseq:NP_851416.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:pr3yhn1QUhZm0o9/xXGd9g+QFoo10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q62261	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:P16546	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-911063|uniprotkb:A3KGU6|uniprotkb:Q8K380|uniprotkb:Q9CT05|uniprotkb:A3KGU8|ensembl:ENSMUSP00000092697	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:sptn1_mouse(display_long)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym)|uniprotkb:Spta2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	dip:DIP-37712N|ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000095083(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032437"(cuticular plate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:P16546|reactome:R-MMU-264870|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:UVB6Kv+PBlqDH3OLoGjxm5oYVPQ10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:O88343	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-771342|uniprotkb:Q3USE4|uniprotkb:Q8BUG0|uniprotkb:Q8QZR9|uniprotkb:Q9R1C4|ensembl:ENSMUSP00000119325	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:s4a4_mouse(display_long)|uniprotkb:"Na(+)/HCO3(-) cotransporter"(gene name synonym)|uniprotkb:Solute carrier family 4 member 4(gene name synonym)|uniprotkb:Slc4a4(gene name)|psi-mi:Slc4a4(display_short)|uniprotkb:Nbc1(gene name synonym)|uniprotkb:Nbce1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_001129732.1|refseq:NP_061230.2|ensembl:ENSMUSG00000060961(gene)|ensembl:ENSMUST00000148750(transcript)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006885"(regulation of pH)|go:"GO:0008510"("sodium:bicarbonate symporter activity")|go:"GO:0009986"(cell surface)|go:"GO:0015293"(symporter activity)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR003024(Sodium bicarbonate cotransporter)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|mint:O88343|reactome:R-MMU-425381	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:gZhNv38fjd32y3e6d63+ixWY5g810090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q91V14	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-771283|uniprotkb:Q9Z0M7|uniprotkb:A2A5L0|uniprotkb:Q3UHQ2|uniprotkb:Q7TQC9|uniprotkb:Q80TI5|ensembl:ENSMUSP00000144623	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:s12a5_mouse(display_long)|uniprotkb:Kiaa1176(gene name synonym)|uniprotkb:Electroneutral potassium-chloride cotransporter 2(gene name synonym)|uniprotkb:K-Cl cotransporter 2(gene name synonym)|uniprotkb:Neuronal K-Cl cotransporter(gene name synonym)|uniprotkb:Slc12a5(gene name)|psi-mi:Slc12a5(display_short)|uniprotkb:Kcc2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_065066.2|refseq:XP_006500006.2|ensembl:ENSMUSG00000017740(gene)|ensembl:ENSMUST00000202623(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006971"(hypotonic response)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0015696"|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040040"(thermosensory behavior)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045202"(synapse)|go:"GO:0051452"(intracellular pH reduction)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0060996"(dendritic spine development)|go:"GO:0071944"(cell periphery)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000076(K-Cl co-transporter)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR018491|interpro:IPR030358|mint:Q91V14|reactome:R-MMU-426117|rcsb pdb:7D14	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:IPFuWDprSLeYLv46uF6WHNQnd7810090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:A2AQ25	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-8821027|ensembl:ENSMUSP00000066170|uniprotkb:A2AUE9|uniprotkb:A2AUF0|uniprotkb:A2AUF1|uniprotkb:Q75UV8|uniprotkb:Q75UV9|uniprotkb:Q80VK2|uniprotkb:Q8BHX8|uniprotkb:Q8BHY1|uniprotkb:Q8CHA8|uniprotkb:Q8R0K6	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:skt_mouse(display_long)|uniprotkb:Skt(gene name)|psi-mi:Skt(display_short)|uniprotkb:Etl4(gene name synonym)|uniprotkb:Kiaa1217(gene name synonym)|uniprotkb:Enhancer trap locus 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	interpro:IPR022782|interpro:IPR026725|mint:A2AQ25|ensembl:ENSMUSG00000036617(gene)|ensembl:ENSMUST00000066509(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0048706"(embryonic skeletal system development)|refseq:NP_001074475.1|refseq:NP_001171101.2|refseq:NP_084171.2|refseq:NP_835160.2|refseq:XP_006497478.1|refseq:XP_006497487.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:WI45C2F/GFoa1PhVnBHPtxCj5mM10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q9JIG4	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-16733019|ensembl:ENSMUSP00000111407|uniprotkb:B1AW09|uniprotkb:B1AW10|uniprotkb:Q3UGL4|uniprotkb:Q6PCL6	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:ppr3f_mouse(display_long)|uniprotkb:Ppp1r3f(gene name)|psi-mi:Ppp1r3f(display_short)|uniprotkb:DXImx48e(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	ensembl:ENSMUSG00000039556(gene)|ensembl:ENSMUST00000115742(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:2000465"("regulation of glycogen (starch) synthase activity")|go:"GO:2001069"(glycogen binding)|interpro:IPR005036(Putative phosphatase regulatory subunit)|refseq:NP_613071.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:4RjfPwwC76KE8ypXYn4ZBUm5MHw10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:O09012	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-646301|uniprotkb:Q3UM58|uniprotkb:Q8K2V5|uniprotkb:Q91YC7|ensembl:ENSMUSP00000049132|ensembl:ENSMUSP00000108151	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:pex5_mouse(display_long)|uniprotkb:Peroxisome receptor 1(gene name synonym)|uniprotkb:Peroxisomal C-terminal targeting signal import receptor(gene name synonym)|uniprotkb:PTS1-BP(gene name synonym)|uniprotkb:Peroxin-5(gene name synonym)|uniprotkb:PXR1P(gene name synonym)|uniprotkb:Pex5(gene name)|psi-mi:Pex5(display_short)|uniprotkb:Pxr1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_033021.2|refseq:NP_787947.1|refseq:NP_001264734.1|refseq:XP_006505821.1|refseq:XP_006505822.1|refseq:NP_001264259.1|refseq:XP_017176951.1|ensembl:ENSMUSG00000005069(gene)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007031"(peroxisome organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|ensembl:ENSMUST00000035861(transcript)|ensembl:ENSMUST00000112532(transcript)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0016561"(protein import into peroxisome matrix, translocation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033328"(peroxisome membrane targeting sequence binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051262"(protein tetramerization)|go:"GO:0140311"(protein sequestering activity)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR024111|interpro:IPR024113|reactome:R-MMU-8866654|go:"GO:0000038"(very long-chain fatty acid metabolic process)|reactome:R-MMU-9033241|reactome:R-MMU-9664873|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0001764"(neuron migration)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:GqfIILxRcIiR64Sc7t0ElWui3dw10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q99NH2	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-6299697|uniprotkb:Q58T10|uniprotkb:Q58T11|uniprotkb:Q8CB21	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:pard3_mouse(display_long)|uniprotkb:Pard3(gene name)|psi-mi:Pard3(display_short)|uniprotkb:Par3(gene name synonym)|uniprotkb:Atypical PKC isotype-specific-interacting protein(gene name synonym)|uniprotkb:Ephrin-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_001013598.1|refseq:NP_001013599.1|go:"GO:0008104"(protein localization)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043296"(apical junction complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|rcsb pdb:2KOH|rcsb pdb:2KOJ|reactome:R-MMU-2173791|reactome:R-MMU-420029|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003383"(apical constriction)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|dip:DIP-41727N|mint:Q99NH2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:T32+accBUmq14vv2OXj2mZe9fzQ10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:P28660	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:P55066	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-774845|uniprotkb:Q6P1E3|uniprotkb:Q8C4F8	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:ncan_mouse(display_long)|uniprotkb:Chondroitin sulfate proteoglycan 3(gene name synonym)|uniprotkb:Ncan(gene name)|psi-mi:Ncan(display_short)|uniprotkb:Cspg3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_031815.2|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR018378|interpro:IPR016187(C-type lectin fold)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR000538(Link)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR036179|mint:P55066|go:"GO:0001501"(skeletal system development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007417"(central nervous system development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0045202"(synapse)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0072534"(perineuronal net)|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|reactome:R-MMU-3000178	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:FbEuo7LHWAZLqfPi0o0JVHNX4Y410090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q99104	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-400199|uniprotkb:E9PUE5|ensembl:ENSMUSP00000116028	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:myo5a_mouse(display_long)|uniprotkb:Myo5a(gene name)|psi-mi:Myo5a(display_short)|uniprotkb:Dilute(gene name synonym)|uniprotkb:Dilute myosin heavy chain, non-muscle(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_034994.2|ensembl:ENSMUSG00000034593(gene)|ensembl:ENSMUST00000123128(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000149"(SNARE binding)|go:"GO:0001726"(ruffle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007601"(visual perception)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014046"(dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031585"(regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031982"(vesicle)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032433"(filopodium tip)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042476"(odontogenesis)|go:"GO:0042552"(myelination)|go:"GO:0042641"(actomyosin)|go:"GO:0042642"(actomyosin, myosin complex part)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043473"(pigmentation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0050808"(synapse organization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051643"(endoplasmic reticulum localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099089"(establishment of endoplasmic reticulum localization to postsynapse)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0099640"(axo-dendritic protein transport)|go:"GO:0150103"(reactive gliosis)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|go:"GO:0030318"(melanocyte differentiation)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR037988|mint:Q99104|rcsb pdb:2IX7|rcsb pdb:3WB8|rcsb pdb:4KP3|rcsb pdb:4ZLK|rcsb pdb:6KU0|reactome:R-MMU-2029482|interpro:IPR002710(Dilute)|go:"GO:0030141"(secretory granule)|dip:DIP-29542N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:8QtBlLL4DqB3An4CoCFVmvBEXBg10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q8VDD5	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-400906|intact:EBI-777674|uniprotkb:Q3UHT9|uniprotkb:Q3UHU4|uniprotkb:Q6KAN6|uniprotkb:Q811I2|ensembl:ENSMUSP00000016771	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:myh9_mouse(display_long)|uniprotkb:Myh9(gene name)|psi-mi:Myh9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_071855.2|ensembl:ENSMUSG00000022443(gene)|ensembl:ENSMUST00000016771(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0097513"(myosin II filament)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903919"(negative regulation of actin filament severing)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q8VDD5|reactome:R-MMU-2029482|reactome:R-MMU-5627123|dip:DIP-29546N	-	-	caution:This sequence has been withdrawn from Uniprot.|crc64:AAAC0E83A0A4F24A	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:qYfcGuWOF9npzsKD3zXTuLeP9iE10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q5DTY9	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-6271974|ensembl:ENSMUSP00000089547|ensembl:ENSMUSP00000158201|uniprotkb:Q78Y50	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:kcd16_mouse(display_long)|uniprotkb:Kctd16(gene name)|psi-mi:Kctd16(display_short)|uniprotkb:Gm1267(gene name synonym)|uniprotkb:Kiaa1317(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	ensembl:ENSMUSG00000051401(gene)|ensembl:ENSMUST00000091927(transcript)|ensembl:ENSMUST00000236889(transcript)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0043235"(receptor complex)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|refseq:NP_080411.1|refseq:XP_017173425.1|refseq:XP_017173426.1|refseq:XP_017173427.1|refseq:XP_017173428.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:zwueT9a7iunyYziWGHoKiD8luq810090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q60625	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-777635|intact:EBI-2935094|uniprotkb:Q2KHL7|uniprotkb:Q3UY19|ensembl:ENSMUSP00000019616|uniprotkb:G5E826	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:icam5_mouse(display_long)|uniprotkb:Telencephalin(gene name synonym)|uniprotkb:Icam5(gene name)|psi-mi:Icam5(display_short)|uniprotkb:Tlcn(gene name synonym)|uniprotkb:Icam3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	reactome:R-MMU-198933|reactome:R-MMU-216083|ensembl:ENSMUSG00000032174(gene)|ensembl:ENSMUST00000019616(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003988(Intercellular adhesion molecule)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q60625|refseq:NP_032345.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:A5LktyV63FCm8TYD3ChcBoYslPc10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:O70507	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-10820097	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:hcn4_mouse(display_long)|uniprotkb:Hcn4(gene name)|psi-mi:Hcn4(display_short)|uniprotkb:Bcng3(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	reactome:R-MMU-1296061|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR014710(RmlC-like jelly roll fold)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:H36ljqPJjhZaCP61Q1savGScDxs10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:O88705	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-11294251|ensembl:ENSMUSP00000029686	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:hcn3_mouse(display_long)|uniprotkb:Hcn3(gene name)|psi-mi:Hcn3(display_short)|uniprotkb:Hac3(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_032253.1|ensembl:ENSMUSG00000028051(gene)|ensembl:ENSMUST00000029686(transcript)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044316"(cone cell pedicle)|go:"GO:0045202"(synapse)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0072718"(response to cisplatin)|go:"GO:1903351"(cellular response to dopamine)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|reactome:R-MMU-1296061	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:fbBs0i3SwNXbEGh8Dw0km9xi1ws10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:O88703	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:O88704	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q68FF6	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-645933|ensembl:ENSMUSP00000037210	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q80T41	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-770749|uniprotkb:A2AL05|ensembl:ENSMUSP00000103378	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:gabr2_mouse(display_long)|uniprotkb:Gm425(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_001074610.1|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|ensembl:ENSMUSG00000039809(gene)|ensembl:ENSMUST00000107749(transcript)|go:"GO:0043005"(neuron projection)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR041689|mint:Q80T41|reactome:R-MMU-1296041|reactome:R-MMU-418594|reactome:R-MMU-420499|reactome:R-MMU-977444|reactome:R-MMU-997272	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:dnGUhfo2YtDMx5QT5gsiVKPUYlw10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q9QXS6	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-445208|uniprotkb:A2CG16|uniprotkb:Q3V234|uniprotkb:Q922X1|uniprotkb:Q9QXS5|ensembl:ENSMUSP00000021950	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:dreb_mouse(display_long)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:Dbn1(gene name)|psi-mi:Dbn1(display_short)|uniprotkb:Drba(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_001170842.1|refseq:NP_001170843.1|refseq:NP_062787.2|ensembl:ENSMUSG00000034675(gene)|ensembl:ENSMUST00000021950(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0005856"(cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048699"(generation of neurons)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0098828"(modulation of inhibitory postsynaptic potential)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:1904113"(negative regulation of muscle filament sliding)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q9QXS6|reactome:R-MMU-9013405|reactome:R-MMU-9013407|reactome:R-MMU-9013418|reactome:R-MMU-9013422	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:ArZUGZNIUfSwoIketPcPCXlSM8410090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q5SQX6	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:O35927	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-774108|uniprotkb:B2RR80	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:ctnd2_mouse(display_long)|uniprotkb:Neural plakophilin-related ARM-repeat protein(gene name synonym)|uniprotkb:Neurojungin(gene name synonym)|uniprotkb:Ctnnd2(gene name)|psi-mi:Ctnnd2(display_short)|uniprotkb:Catnd2(gene name synonym)|uniprotkb:Nprap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0045296"(cadherin binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR028435|refseq:NP_032755.2|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|mint:O35927	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:/YXEXiU6UKZhK6McB762K0GKcN010090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:P26231	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-647895|ensembl:ENSMUSP00000049007	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:ctna1_mouse(display_long)|uniprotkb:102 kDa cadherin-associated protein(gene name synonym)|uniprotkb:CAP102(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Ctnna1(gene name)|psi-mi:Ctnna1(display_short)|uniprotkb:Catna1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_033948.1|refseq:XP_011245120.1|dip:DIP-35299N|ensembl:ENSMUSG00000037815(gene)|ensembl:ENSMUST00000042345(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P26231|rcsb pdb:1DOV|rcsb pdb:1DOW|rcsb pdb:1L7C|rcsb pdb:4E17|rcsb pdb:4E18|rcsb pdb:4K1N|rcsb pdb:5Y04|rcsb pdb:6DV1|rcsb pdb:6O3E|rcsb pdb:6WVT|reactome:R-MMU-418990|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:2GScCoVKWPHfjBJE6Gm6yVmO/IA10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q02248	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q61301	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-774089|uniprotkb:Q61300|uniprotkb:Q6AXD1|uniprotkb:Q3TY37|ensembl:ENSMUSP00000124376	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:ctna2_mouse(display_long)|uniprotkb:Alpha N-catenin(gene name synonym)|uniprotkb:Ctnna2(gene name)|psi-mi:Ctnna2(display_short)|uniprotkb:Catna2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_001103234.1|refseq:NP_033949.2|refseq:NP_663785.2|dip:DIP-31971N|refseq:XP_011239496.1|refseq:XP_017176861.1|ensembl:ENSMUSG00000063063(gene)|ensembl:ENSMUST00000159626(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030046|interpro:IPR036723|mint:Q61301|rcsb pdb:4K1O|rcsb pdb:4ONS|rcsb pdb:4P9T|rcsb pdb:5XFL|rcsb pdb:6DUY|reactome:R-MMU-525793	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:0z1O3ZeQwbjZawJfbXvb+dGAWYU10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:P15116	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-397974|uniprotkb:Q64260|uniprotkb:Q6GU11|intact:EBI-2255565|ensembl:ENSMUSP00000025166	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:cadh2_mouse(display_long)|uniprotkb:Cdh2(gene name)|psi-mi:Cdh2(display_short)|uniprotkb:Neural cadherin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_031690.3|ensembl:ENSMUSG00000024304(gene)|ensembl:ENSMUST00000025166(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030315"(T-tubule)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|interpro:IPR027397|interpro:IPR030051|interpro:IPR039808|mint:P15116|rcsb pdb:1NCG|rcsb pdb:1NCH|rcsb pdb:1NCI|rcsb pdb:1NCJ|rcsb pdb:1OP4|rcsb pdb:2QVI|rcsb pdb:3Q2W|rcsb pdb:4NUM|rcsb pdb:4NUP|rcsb pdb:4NUQ|reactome:R-MMU-381426|reactome:R-MMU-418990|reactome:R-MMU-525793|reactome:R-MMU-8957275|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090497"(mesenchymal cell migration)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|go:"GO:0043005"(neuron projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|dip:DIP-31564N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:Yon1udPwyvjKP2+GVGUcrsZtFng10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:P55288	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-15926945|ensembl:ENSMUSP00000074681	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:cad11_mouse(display_long)|uniprotkb:Cdh11(gene name)|psi-mi:Cdh11(display_short)|uniprotkb:Cad-11(gene name synonym)|uniprotkb:OSF-4(gene name synonym)|uniprotkb:Osteoblast cadherin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	ensembl:ENSMUSG00000031673(gene)|ensembl:ENSMUST00000075190(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0034332"(adherens junction organization)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR039808|rcsb pdb:2A4C|rcsb pdb:2A4E|rcsb pdb:6CGB|reactome:R-MMU-418990|refseq:NP_033996.4|refseq:XP_006530686.1|refseq:XP_006530687.1|refseq:XP_006530689.1|dip:DIP-59088N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:qgCbhesC9496btazK4+QQazuqfM10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q6P9K8	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-771526|uniprotkb:Q6ZPU2|uniprotkb:Q8BWU2|uniprotkb:Q8BX99|uniprotkb:Q9CXH0|ensembl:ENSMUSP00000024958	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:cski1_mouse(display_long)|uniprotkb:CASK-interacting protein 1(gene name synonym)|uniprotkb:Caskin1(gene name)|psi-mi:Caskin1(display_short)|uniprotkb:Kiaa1306(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_082213.2|refseq:XP_006524378.1|ensembl:ENSMUSG00000033597(gene)|ensembl:ENSMUST00000024958(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001452(Src homology-3)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR027013|interpro:IPR032117|interpro:IPR032232|interpro:IPR035495|interpro:IPR035497|interpro:IPR035498|interpro:IPR036028|interpro:IPR036770|mint:Q6P9K8	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:zLkBAG7MLTXtMQ0HlY2ox2AumUE10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:P11798	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q60875	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-772191|uniprotkb:E9QNW9|uniprotkb:O09115|uniprotkb:Q3TBI4|uniprotkb:Q3TJ16|uniprotkb:Q8CHE1|uniprotkb:Q923E0|uniprotkb:Q9ESG7|ensembl:ENSMUSP00000029694	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:arhg2_mouse(display_long)|uniprotkb:Kiaa0651(gene name synonym)|uniprotkb:Lbcl1(gene name synonym)|uniprotkb:Lfc(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Lymphoid blast crisis-like 1(gene name synonym)|uniprotkb:LBC'S first cousin(gene name synonym)|uniprotkb:Oncogene LFC(gene name synonym)|uniprotkb:Rhobin(gene name synonym)|uniprotkb:Arhgef2(gene name)|psi-mi:Arhgef2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_001185840.1|refseq:NP_001185841.1|refseq:NP_001185842.1|refseq:NP_032513.3|refseq:XP_006501130.1|ensembl:ENSMUSG00000028059(gene)|ensembl:ENSMUST00000029694(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002102"(podosome)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071802"(negative regulation of podosome assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037806|interpro:IPR041020|mint:Q60875|rcsb pdb:5WI4|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:Le4PMm1AT/ManVpetNT2wBsUlok10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q9DBG3	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-775229|uniprotkb:Q80XJ4|ensembl:ENSMUSP00000070714	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:ap2b1_mouse(display_long)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:Ap2b1(gene name)|psi-mi:Ap2b1(display_short)|uniprotkb:Clapb1(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_001030931.1|refseq:NP_082191.1|refseq:XP_006534321.1|refseq:XP_017170261.1|dip:DIP-32161N|ensembl:ENSMUSG00000035152(gene)|ensembl:ENSMUST00000065692(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0035904"(aorta development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q9DBG3|rcsb pdb:6OWO|rcsb pdb:6OXL|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:YWwOqRpXCJDwzrLv27muBx1+DHI10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:P17427	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-775215|uniprotkb:Q8C2J5|uniprotkb:Q921V0|ensembl:ENSMUSP00000003038	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:ap2a2_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)|uniprotkb:Adtab(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_031485.3|dip:DIP-32160N|ensembl:ENSMUSG00000002957(gene)|ensembl:ENSMUST00000003038(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030141"(secretory granule)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:P17427|rcsb pdb:1B9K|rcsb pdb:1KY6|rcsb pdb:1KY7|rcsb pdb:1KYD|rcsb pdb:1KYF|rcsb pdb:1KYU|rcsb pdb:1QTP|rcsb pdb:1QTS|rcsb pdb:1W80|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VJ0|rcsb pdb:3HS8|rcsb pdb:6OWO|rcsb pdb:6OXL|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-6798695|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:KlOjm5d8qxxQkcuD2Hukoj8DLss10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:P17426	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-775189|ensembl:ENSMUSP00000082519|ensembl:ENSMUSP00000127842	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:ap2a1_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Ap2a1(gene name)|psi-mi:Ap2a1(display_short)|uniprotkb:Adtaa(gene name synonym)|uniprotkb:Clapa1(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_001070732.1|refseq:NP_031484.1|ensembl:ENSMUSG00000060279(gene)|ensembl:ENSMUST00000085399(transcript)|ensembl:ENSMUST00000166972(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0032433"(filopodium tip)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:P17426|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:Dd6Q+Et/LTlmo5qpro2Zaeq0dMc10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q8C8R3	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-774322|intact:EBI-2133064|uniprotkb:Q6PCN2|uniprotkb:Q3TM62|uniprotkb:Q3V2X0|uniprotkb:Q80ZZ7|uniprotkb:Q8BNC1|uniprotkb:Q8C445|uniprotkb:Q8CCV0|intact:EBI-2255612|intact:EBI-8314005|intact:MINT-4115219	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:ank2_mouse(display_long)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:AnkB(gene name synonym)|uniprotkb:Ank2(gene name)|psi-mi:Ank2(display_short)|uniprotkb:Ankyrin-B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_001029340.1|refseq:NP_848770.2|dip:DIP-58645N|mint:Q8C8R3|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001257"(regulation of cation channel activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:SkB13oxZVcKuMnI8r5ItFIq2pXQ10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q8CJF9	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-9030886|uniprotkb:Q3TBP7|ensembl:ENSMUSP00000066633	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:ago3_mouse(display_long)|uniprotkb:Ago3(gene name)|psi-mi:Ago3(display_short)|uniprotkb:Eif2c3(gene name synonym)|uniprotkb:Argonaute RISC catalytic component 3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 3(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_700451.2|ensembl:ENSMUSG00000028842(gene)|ensembl:ENSMUST00000069097(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028603|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJF9|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:JBJer7uFfQamp+D9D7xPSd0iPuo10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q8CJG1	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-2291996|uniprotkb:A1L365|ensembl:ENSMUSP00000095498|ensembl:ENSMUSP00000159361	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:ago1_mouse(display_long)|uniprotkb:Ago1(gene name)|psi-mi:Ago1(display_short)|uniprotkb:Argonaute RISC catalytic component 1(gene name synonym)|uniprotkb:Eif2c1(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 1(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_700452.2|refseq:NP_001304102.1|ensembl:ENSMUSG00000041530(gene)|ensembl:ENSMUST00000097888(transcript)|ensembl:ENSMUST00000239428(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070578"(RISC-loading complex)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG1|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:l/WmIsnfJjifEOoxOyG9zDo2ljQ10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C437	uniprotkb:Q9QYC0	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	intact:EBI-774264|uniprotkb:Q9JLE3|ensembl:ENSMUSP00000109979	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:adda_mouse(display_long)|uniprotkb:Erythrocyte adducin subunit alpha(gene name synonym)|uniprotkb:Add1(gene name)|psi-mi:Add1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733066|imex:IM-26285-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_001318009.1|refseq:NP_001318016.1|refseq:NP_001019629.2|refseq:NP_038485.1|refseq:XP_017176104.1|refseq:NP_001095914.1|ensembl:ENSMUSG00000029106(gene)|ensembl:ENSMUST00000114340(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1903393"(positive regulation of adherens junction organization)|interpro:IPR001303(Class II aldolase/adducin, N-terminal)|interpro:IPR027766|interpro:IPR036409|mint:Q9QYC0|reactome:R-MMU-264870|reactome:R-MMU-5223345	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rogid:Z5ZTggQNVfhxzdHaJH8OaQC0FXk10090	rigid:JOYsHF6iLYVkCJzjvmyg3G4y0zk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q8CGM1	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-8014984|uniprotkb:B1ASB7|intact:MINT-1504097|uniprotkb:Q6PGN0|uniprotkb:B1ASB8|uniprotkb:Q3UNE2|uniprotkb:Q3TYC8|uniprotkb:Q3UN11|uniprotkb:B2FDE3|ensembl:ENSMUSP00000101636	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:agrb2_mouse(display_long)|uniprotkb:Adgrb2(gene name)|psi-mi:Adgrb2(display_short)|uniprotkb:Bai2(gene name synonym)|uniprotkb:Brain-specific angiogenesis inhibitor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001186625.1|refseq:NP_775094.2|refseq:NP_001277643.1|refseq:NP_001277644.1|ensembl:ENSMUSG00000028782(gene)|ensembl:ENSMUST00000106015(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0051965"(positive regulation of synapse assembly)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR008077(GPCR, family 2, brain-specific angiogenesis inhibitor)|interpro:IPR017981|interpro:IPR032471|interpro:IPR036383|interpro:IPR036445|interpro:IPR043838	-	-	function:Might be involved in angiogenesis inhibition|comment:mint|comment:homomint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:8rlZowKB2ecMLVMojYSZDIwjx9410090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P84084	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-7569461|uniprotkb:P26437|intact:UNK-5383724|uniprotkb:A2RTC5|ensembl:ENSMUSP00000020717|ensembl:ENSMUSP00000127281	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:arf5_mouse(display_long)|uniprotkb:Arf5(gene name)|psi-mi:Arf5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_031506.1|ensembl:ENSMUSG00000020440(gene)|ensembl:ENSMUST00000020717(transcript)|ensembl:ENSMUST00000169841(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|reactome:R-MMU-6807878|reactome:R-MMU-6811434	-	-	function:GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus|comment:mint|comment:homomint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:da8exbGR3MGxZ6CPZqLvqJbyUYI10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q80TS7	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-16725318|ensembl:ENSMUSP00000074895|uniprotkb:Q3TPT2|uniprotkb:Q3TY46	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dend_mouse(display_long)|uniprotkb:Ddn(gene name)|psi-mi:Ddn(display_short)|uniprotkb:Gm748(gene name synonym)|uniprotkb:Kiaa0749(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000059213(gene)|ensembl:ENSMUST00000075444(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0042995"(cell projection)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR026500|rcsb pdb:6J69|rcsb pdb:6JJZ|rcsb pdb:6JK0|rcsb pdb:6JK1|rcsb pdb:6KKG|rcsb pdb:7BQG|refseq:NP_001013763.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:XTb8iMdZY6ldSiQVXuwx2ofQeVs10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q9JLV5	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2551335|ensembl:ENSMUSP00000130738	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:cul3_mouse(display_long)|uniprotkb:Cul3(gene name)|psi-mi:Cul3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000004364(gene)|ensembl:ENSMUST00000163119(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q9JLV5|rcsb pdb:1IUY|reactome:R-MMU-4641258|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-8932339|reactome:R-MMU-8951664|go:"GO:0030030"(cell projection organization)|reactome:R-MMU-9013418|reactome:R-MMU-9013422|reactome:R-MMU-9706019|reactome:R-MMU-983168|refseq:NP_057925.1|refseq:NP_001300657.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:tSFsLPpnn80evlnxKTXO5olW5Xg10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q80UP3	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-971774|uniprotkb:A2AHJ6|ensembl:ENSMUSP00000028667	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dgkz_mouse(display_long)|uniprotkb:Dgkz(gene name)|psi-mi:Dgkz(display_short)|uniprotkb:Diglyceride kinase zeta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000040479(gene)|ensembl:ENSMUST00000028667(transcript)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046486"(glycerolipid metabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046834"(lipid phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090216"(positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR000756(Diacylglycerol kinase accessory region)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR002110(Ankyrin)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|interpro:IPR020683|interpro:IPR036770|reactome:R-MMU-114508|interpro:IPR037607|go:"GO:0001727"(lipid kinase activity)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0030027"(lamellipodium)|refseq:NP_612179.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:Q+JMToiGaqYHQn4Hk9FpJihw7XM10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:O54991	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-774794|uniprotkb:A2A4K6|ensembl:ENSMUSP00000099398	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:cntp1_mouse(display_long)|uniprotkb:Neurexin-4(gene name synonym)|uniprotkb:Neurexin IV(gene name synonym)|uniprotkb:Paranodin(gene name synonym)|uniprotkb:NCP1(gene name synonym)|uniprotkb:MHDNIV(gene name synonym)|uniprotkb:Cntnap1(gene name)|psi-mi:Cntnap1(display_short)|uniprotkb:Nrxn4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_058062.2|ensembl:ENSMUSG00000017167(gene)|ensembl:ENSMUST00000103109(transcript)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0005886"(plasma membrane)|go:"GO:0005918"(septate junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030424"(axon)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0033010"(paranodal junction)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR028872|interpro:IPR036056|mint:O54991	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:BTW+FjgSUq00WpWGDC6PpQcIowE10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q5M8N0	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-16733235|ensembl:ENSMUSP00000050036|uniprotkb:Q3TAC7|uniprotkb:Q3UFR2	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:cnrp1_mouse(display_long)|uniprotkb:Cnrip1(gene name)|psi-mi:Cnrip1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000044629(gene)|ensembl:ENSMUST00000058159(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0031718"(type 1 cannabinoid receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:2000272"(negative regulation of signaling receptor activity)|interpro:IPR029204|mint:Q5M8N0|refseq:NP_084137.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:d4VBaXMMjEQ11X2/zohvbiwN3k010090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P28652	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P11798	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:O88602	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-770326|ensembl:ENSMUSP00000019290	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:ccg2_mouse(display_long)|uniprotkb:Neuronal voltage-gated calcium channel gamma-2 subunit(gene name synonym)|uniprotkb:Stargazin(gene name synonym)|uniprotkb:Cacng2(gene name)|psi-mi:Cacng2(display_short)|uniprotkb:Stg(gene name synonym)|uniprotkb:Transmembrane AMPAR regulatory protein gamma-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_031609.1|dip:DIP-32457N|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016247"(channel regulator activity)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0050877"(nervous system process)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060082"(eye blink reflex)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099590"(neurotransmitter receptor internalization)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904510"(positive regulation of protein localization to basolateral plasma membrane)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR005422(Voltage-dependent calcium channel, gamma-2 subunit)|interpro:IPR008368(Voltage-dependent calcium channel, gamma subunit)|rcsb pdb:3JXT|rcsb pdb:4X3H|rcsb pdb:5KBS|rcsb pdb:5KBT|rcsb pdb:5KBU|rcsb pdb:5WEO|reactome:R-MMU-112308|reactome:R-MMU-399719|reactome:R-MMU-5682910|ensembl:ENSMUSG00000019146(gene)|ensembl:ENSMUST00000019290(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006612"(protein targeting to membrane)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:horuxO013U9eKJYCTV7fS8OC0BY10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q8CC27	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-9690121|uniprotkb:A2ASJ8|uniprotkb:Q8C5J5|uniprotkb:Q9CTQ6|ensembl:ENSMUSP00000110371	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:cacb2_mouse(display_long)|uniprotkb:Cacnb2(gene name)|psi-mi:Cacnb2(display_short)|uniprotkb:Cacnlb2(gene name synonym)|uniprotkb:Calcium channel voltage-dependent subunit beta 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001296448.1|refseq:NP_075605.1|refseq:XP_006497383.1|ensembl:ENSMUSG00000057914(gene)|ensembl:ENSMUST00000114723(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007601"(visual perception)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070509"(calcium ion import)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1901843"(positive regulation of high voltage-gated calcium channel activity)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR001452(Src homology-3)|interpro:IPR005444(Voltage-dependent calcium channel, L-type, beta-2 subunit)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035605|interpro:IPR036028|reactome:R-MMU-112308|reactome:R-MMU-422356|reactome:R-MMU-5576892|reactome:R-MMU-5576893	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:v56B+tEzuDuYnl4Fri/+kK+ccSo10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q8C726	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-16733202|ensembl:ENSMUSP00000078845|ensembl:ENSMUSP00000127300|ensembl:ENSMUSP00000157449	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:btbd9_mouse(display_long)|uniprotkb:Btbd9(gene name)|psi-mi:Btbd9(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000062202(gene)|ensembl:ENSMUST00000079924(transcript)|ensembl:ENSMUST00000168787(transcript)|ensembl:ENSMUST00000237048(transcript)|go:"GO:0007616"(long-term memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042748"(circadian sleep/wake cycle, non-REM sleep)|go:"GO:0048512"(circadian behavior)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050951"(sensory perception of temperature stimulus)|go:"GO:0060586"(multicellular organismal iron ion homeostasis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR034091|refseq:NP_081336.1|refseq:NP_766206.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:7vki1FWZ5tJ1pPI3u/Mq54VkFis10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q68EF6	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2310845|ensembl:ENSMUSP00000158999	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:begin_mouse(display_long)|uniprotkb:Begain(gene name)|psi-mi:Begain(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:XP_011242432.1|refseq:NP_001156647.1|refseq:XP_006516107.1|ensembl:ENSMUSG00000040867(gene)|ensembl:ENSMUST00000238841(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098817"(evoked excitatory postsynaptic potential)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR033584|interpro:IPR043441	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:F3zprvxGqUithFEHDTFZJDTWiOA10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q91XV3	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-772877|ensembl:ENSMUSP00000053943	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:basp1_mouse(display_long)|uniprotkb:Neuronal axonal membrane protein NAP-22(gene name synonym)|uniprotkb:22 kDa neuronal tissue-enriched acidic protein(gene name synonym)|uniprotkb:Basp1(gene name)|psi-mi:Basp1(display_short)|uniprotkb:Nap22(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_081671.1|ensembl:ENSMUSG00000045763(gene)|ensembl:ENSMUST00000058845(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030426"(growth cone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|interpro:IPR008408(Brain acid soluble protein 1)|mint:Q91XV3|reactome:R-MMU-9035034	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:dwUwWfxMdUr+bki6HEHeaEibNOQ10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q8BKX1	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P61205	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-444797|uniprotkb:P16587|ensembl:ENSMUSP00000050689	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:arf3_mouse(display_long)|uniprotkb:Arf3(gene name)|psi-mi:Arf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_031504.1|refseq:XP_011243747.1|ensembl:ENSMUSG00000051853(gene)|ensembl:ENSMUST00000053183(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P61205|reactome:R-MMU-1660514|reactome:R-MMU-6807878|reactome:R-MMU-6811434	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:np09WjdbXRu9vgMbiXn9EA3ExqA10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q8BIZ1	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-16724439|uniprotkb:E9Q644|uniprotkb:Q4KMR9|uniprotkb:Q8BJ47|uniprotkb:Q8BJ49	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:ans1b_mouse(display_long)|uniprotkb:Amyloid-beta protein intracellular domain-associated protein 1(gene name synonym)|uniprotkb:E2A-PBX1-associated protein(gene name synonym)|uniprotkb:Anks1b(gene name)|psi-mi:Anks1b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	interpro:IPR041880|interpro:IPR041882|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900383"(regulation of synaptic plasticity by receptor localization to synapse)|mint:Q8BIZ1|refseq:NP_001170868.1|refseq:NP_001170869.1|refseq:NP_001333982.1|refseq:NP_001333983.1|refseq:NP_852063.1|interpro:IPR033636|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:xm2OG9kb/tmIo7e7c/qXBE4JeAY10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q8C8R3	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-774322|intact:EBI-2133064|uniprotkb:Q6PCN2|uniprotkb:Q3TM62|uniprotkb:Q3V2X0|uniprotkb:Q80ZZ7|uniprotkb:Q8BNC1|uniprotkb:Q8C445|uniprotkb:Q8CCV0|intact:EBI-2255612|intact:EBI-8314005|intact:MINT-4115219	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:ank2_mouse(display_long)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:AnkB(gene name synonym)|uniprotkb:Ank2(gene name)|psi-mi:Ank2(display_short)|uniprotkb:Ankyrin-B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001029340.1|refseq:NP_848770.2|dip:DIP-58645N|mint:Q8C8R3|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001257"(regulation of cation channel activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:SkB13oxZVcKuMnI8r5ItFIq2pXQ10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q3UHD9	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-771911|uniprotkb:Q5DU45|ensembl:ENSMUSP00000043466	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:agap2_mouse(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Kiaa0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001028435.1|refseq:NP_001287943.1|ensembl:ENSMUSG00000025422(gene)|ensembl:ENSMUST00000039259(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|go:"GO:0005768"(endosome)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:yq2lQtfk+FPqgT++CxAx2CS69nE10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q61072	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-77983|uniprotkb:E9QPP2|ensembl:ENSMUSP00000081048|uniprotkb:Q60618|uniprotkb:Q61853|uniprotkb:Q80U94	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:adam9_mouse(display_long)|uniprotkb:Adam9(gene name)|psi-mi:Adam9(display_short)|uniprotkb:Kiaa0021(gene name synonym)|uniprotkb:Mdc9(gene name synonym)|uniprotkb:Mltng(gene name synonym)|uniprotkb:Metalloprotease/disintegrin/cysteine-rich protein 9(gene name synonym)|uniprotkb:Myeloma cell metalloproteinase(gene name synonym)|uniprotkb:Meltrin-gamma(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000031555(gene)|ensembl:ENSMUST00000084035(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031233"(intrinsic component of external side of plasma membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042117"(monocyte activation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043236"(laminin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|refseq:NP_031430.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:GSTKev8sg5lfwupVNEpPkPhFxHA10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q9R1V6	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-770007|uniprotkb:Q5TLI8|uniprotkb:Q5TLI9|uniprotkb:Q5TLJ0|uniprotkb:Q5TLJ1|uniprotkb:Q5TLJ2|uniprotkb:Q5TLJ3|uniprotkb:Q5TLJ4|uniprotkb:Q5TLJ5|uniprotkb:Q5TLJ6|uniprotkb:Q5TLJ7|uniprotkb:Q5TLJ8|uniprotkb:Q5TLJ9|uniprotkb:Q5TLK0|uniprotkb:Q5TLK1|uniprotkb:Q5TLK2|uniprotkb:Q5TLK3|uniprotkb:Q5TLK4|uniprotkb:Q5TLK5|uniprotkb:Q5TLK6|uniprotkb:Q5TLK7|uniprotkb:Q5TLK8|uniprotkb:Q8BSF2|uniprotkb:Q9R1V5|ensembl:ENSMUSP00000086139	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:ada22_mouse(display_long)|uniprotkb:Adam22(gene name)|psi-mi:Adam22(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001007221.1|refseq:NP_001007222.1|refseq:NP_001091695.1|refseq:NP_001297368.1|refseq:NP_001297369.1|refseq:XP_006503592.1|refseq:XP_006503593.1|refseq:XP_006503594.1|refseq:XP_006503596.1|refseq:XP_006503598.1|refseq:XP_006503600.1|refseq:XP_006503605.1|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR013111(EGF, extracellular)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:Q9R1V6|reactome:R-MMU-5682910|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|ensembl:ENSMUSG00000040537(gene)|ensembl:ENSMUST00000088761(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030424"(axon)|go:"GO:0042063"(gliogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:jOd0AHmc5bv3EK95Q84gaYLiKx010090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q8K4G5	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2307994|uniprotkb:Q80U86|uniprotkb:Q8BIR9|uniprotkb:Q8K4G3|uniprotkb:Q8K4G4	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:ablm1_mouse(display_long)|uniprotkb:Ablim1(gene name)|psi-mi:Ablim1(display_short)|uniprotkb:Ablim(gene name synonym)|uniprotkb:Kiaa0059(gene name synonym)|uniprotkb:Actin-binding LIM protein family member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001096647.1|refseq:NP_848803.3|interpro:IPR003128(Villin headpiece)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_001096648.1|refseq:NP_001277742.1|refseq:NP_001277744.1|interpro:IPR032402|interpro:IPR028448|mint:Q8K4G5|interpro:IPR036886|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060271"(cilium assembly)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:UteUUoDaSxN+RrZNRUyx9jrzqHc10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P63101	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P68510	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-444641|uniprotkb:P11576|uniprotkb:P70198|uniprotkb:Q3TGZ9|ensembl:ENSMUSP00000019109	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:1433f_mouse(display_long)|uniprotkb:Ywhah(gene name)|psi-mi:Ywhah(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_035868.1|ensembl:ENSMUSG00000018965(gene)|ensembl:ENSMUST00000019109(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P68510|rcsb pdb:5YQG|go:"GO:0006886"(intracellular protein transport)|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:Ew2uUYIXrZ8nnP52xMnGB6KOCqc10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P61982	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-359843|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q4FK44|uniprotkb:Q3UFD6|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSMUSP00000051223|ensembl:ENSMUSP00000143631	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:1433g_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_061359.2|ensembl:ENSMUSG00000051391(gene)|ensembl:ENSMUST00000055808(transcript)|ensembl:ENSMUST00000198270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61982|reactome:R-MMU-111447|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-9614399	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P62259	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q80TP3	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2553642|uniprotkb:Q810V6|uniprotkb:Q698K9|uniprotkb:Q9CXE9|uniprotkb:Q6PFQ9|uniprotkb:Q80VL4|uniprotkb:Q6PEQ8	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:ubr5_mouse(display_long)|uniprotkb:Ubr5(gene name)|psi-mi:Ubr5(display_short)|uniprotkb:Edd(gene name synonym)|uniprotkb:Edd1(gene name synonym)|uniprotkb:Kiaa0896(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase, HECT domain-containing 1(gene name synonym)|uniprotkb:Hyperplastic discs protein homolog(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase UBR5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR000569(HECT)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR024725|interpro:IPR035983|interpro:IPR036053|go:"GO:0061630"(ubiquitin protein ligase activity)|refseq:NP_001074828.2|refseq:NP_001106192.1|dip:DIP-56890N|mint:Q80TP3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:iUtn1CtWFtqWQV3UH06xJ5R5Ux010090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q8CHC4	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-775693	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:synj1_mouse(display_long)|uniprotkb:Synj1(gene name)|psi-mi:Synj1(display_short)|uniprotkb:Kiaa0910(gene name synonym)|uniprotkb:Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	interpro:IPR015047(Region of unknown function DUF1866)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002013(Synaptojanin, N-terminal)|interpro:IPR034971|interpro:IPR034972|interpro:IPR035979|interpro:IPR036691|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:Q8CHC4|go:"GO:0003723"(RNA binding)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014015"(positive regulation of gliogenesis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030118"(clathrin coat)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904980"(positive regulation of endosome organization)|go:"GO:1990175"(EH domain binding)|reactome:R-MMU-1660499|reactome:R-MMU-1855183|reactome:R-MMU-1855204|reactome:R-MMU-8856828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:jBMEFlptiz90uS1F1ajBc7zR3vo10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:O88935	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-775644|uniprotkb:Q62279|uniprotkb:Q8QZT8|ensembl:ENSMUSP00000080568	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:syn1_mouse(display_long)|uniprotkb:Synapsin I(gene name synonym)|uniprotkb:Syn1(gene name)|psi-mi:Syn1(display_short)|uniprotkb:Syn-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001104250.1|refseq:NP_038708.3|ensembl:ENSMUSG00000037217(gene)|ensembl:ENSMUST00000081893(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043229"(intracellular organelle)|go:"GO:0045202"(synapse)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048666"(neuron development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050808"(synapse organization)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099504"(synaptic vesicle cycle)|interpro:IPR001359(Synapsin)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR019735|interpro:IPR019736|interpro:IPR020897|interpro:IPR020898|interpro:IPR028713|mint:O88935|reactome:R-MMU-181429|reactome:R-MMU-212676	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:z48y84jWlS6gOiBDyvxI+aRYzdY10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q68FG2	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2255511|ensembl:ENSMUSP00000008991	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:q68fg2_mouse(display_long)|uniprotkb:Sptbn2(gene name)|psi-mi:Sptbn2(display_short)|uniprotkb:Spnb3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_067262.1|refseq:XP_006531767.1|refseq:XP_006531768.1|ensembl:ENSMUSG00000067889(gene)|ensembl:ENSMUST00000008991(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008091"(spectrin)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0030534"(adult behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051693"(actin filament capping)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098918"(structural constituent of synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:0099189"(postsynaptic spectrin-associated cytoskeleton)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-MMU-2132295|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:2F7U0dl21KxXpc9Z2sk7D/wzQvM10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q62261	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P56564	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2310175|uniprotkb:Q99P53|ensembl:ENSMUSP00000005493	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:eaa1_mouse(display_long)|uniprotkb:Slc1a3(gene name)|psi-mi:Slc1a3(display_short)|uniprotkb:Eaat1(gene name synonym)|uniprotkb:Gmt1(gene name synonym)|uniprotkb:Sodium-dependent glutamate/aspartate transporter 1(gene name synonym)|uniprotkb:High-affinity neuronal glutamate transporter(gene name synonym)|uniprotkb:Glial high affinity glutamate transporter(gene name synonym)|uniprotkb:Solute carrier family 1 member 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_683740.1|go:"GO:1902476"(chloride transmembrane transport)|interpro:IPR001991("Sodium:dicarboxylate symporter")|interpro:IPR018107|interpro:IPR036458|mint:P56564|reactome:R-MMU-210455|reactome:R-MMU-210500|reactome:R-MMU-425393|ensembl:ENSMUSG00000005360(gene)|ensembl:ENSMUST00000005493(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005314"(high-affinity glutamate transmembrane transporter activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009449"(gamma-aminobutyric acid biosynthetic process)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015501"("glutamate:sodium symporter activity")|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0016597"(amino acid binding)|go:"GO:0021545"(cranial nerve development)|go:"GO:0031223"(auditory behavior)|go:"GO:0042493"|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045202"(synapse)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051938"(L-glutamate import)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071944"(cell periphery)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098796"(membrane protein complex)|go:"GO:0140009"(L-aspartate import across plasma membrane)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:XRqZRejwe6BDoF8prYq/KDlMn2010090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q4ACU6	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q80Z38	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-770338|uniprotkb:E9QPH7|uniprotkb:Q3UTK4|uniprotkb:Q5DU07	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:shan2_mouse(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)|uniprotkb:Kiaa1022(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001074839.2|refseq:NP_001106844.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001452(Src homology-3)|refseq:XP_006508596.1|reactome:R-MMU-6794361|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0043005"(neuron projection)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:OTohbAMxKtx7/WWwWXDc+c24HvQ10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:D3YZU1	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2314988|ensembl:ENSMUSP00000103571	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:shan1_mouse(display_long)|uniprotkb:Shank1(gene name)|psi-mi:Shank1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001029287.1|refseq:XP_006540927.1|ensembl:ENSMUSG00000038738(gene)|ensembl:ENSMUST00000107938(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:TbxBmjjabypLqTlAx9zbkSAAzpk10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P62823	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-4286215|uniprotkb:Q62858|uniprotkb:Q62974|uniprotkb:Q63482|uniprotkb:Q9CXQ1|ensembl:ENSMUSP00000132945	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:rab3c_mouse(display_long)|uniprotkb:Rab3c(gene name)|psi-mi:Rab3c(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_076341.1|ensembl:ENSMUSG00000021700(gene)|ensembl:ENSMUST00000167824(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037872|reactome:R-MMU-8873719	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:F0BXS2E7Unlk+uNhGFX8SXRN9hA10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P63011	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-398393|uniprotkb:P05713|uniprotkb:Q3TSL4|ensembl:ENSMUSP00000034301|ensembl:ENSMUSP00000105719|ensembl:ENSMUSP00000105720|ensembl:ENSMUSP00000105717	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:rab3a_mouse(display_long)|uniprotkb:Rab3a(gene name)|psi-mi:Rab3a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001159871.1|refseq:NP_033027.1|ensembl:ENSMUSG00000031840(gene)|refseq:XP_006509666.1|refseq:NP_001314976.1|dip:DIP-31051N|ensembl:ENSMUST00000034301(transcript)|ensembl:ENSMUST00000110090(transcript)|ensembl:ENSMUST00000110092(transcript)|ensembl:ENSMUST00000110093(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0003016"(respiratory system process)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009306"(protein secretion)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030141"(secretory granule)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031630"(regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0043195"(terminal bouton)|go:"GO:0043229"(intracellular organelle)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048790"(maintenance of presynaptic active zone structure)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051021"(GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061670"(evoked neurotransmitter secretion)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1905684"(regulation of plasma membrane repair)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037872|mint:P63011|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-6798695|reactome:R-MMU-8873719|reactome:R-MMU-8876198|reactome:R-MMU-888590	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:Skrsn0x0LP/jAuOk1LQ4ataeiDA10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P53994	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-444664|uniprotkb:Q3UK45|ensembl:ENSMUSP00000057664	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:rab2a_mouse(display_long)|uniprotkb:Rab2(gene name synonym)|uniprotkb:Rab2a(gene name)|psi-mi:Rab2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_067493.1|ensembl:ENSMUSG00000047187(gene)|ensembl:ENSMUST00000060232(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P53994|reactome:R-MMU-162658|reactome:R-MMU-8873719|go:"GO:0098993"(anchored component of synaptic vesicle membrane)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:gBkMWVEMfkyF8vxEHTY8IM6VYAI10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P61027	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-911581|uniprotkb:O88386|uniprotkb:Q9D7X6|ensembl:ENSMUSP00000021001	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:rab10_mouse(display_long)|uniprotkb:Rab10(gene name)|psi-mi:Rab10(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_057885.1|dip:DIP-37720N|ensembl:ENSMUSG00000020671(gene)|ensembl:ENSMUST00000021001(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0031489"(myosin V binding)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051021"(GDP-dissociation inhibitor binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61027|reactome:R-MMU-6798695|reactome:R-MMU-8873719|reactome:R-MMU-8876198	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:ZbfLtWtXl3z6/MYyhiZp6P1Y5tE10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P42669	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-773823|ensembl:ENSMUSP00000059404	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:pura_mouse(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:Pura(gene name)|psi-mi:Pura(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_033015.1|refseq:XP_006525787.1|refseq:XP_011245162.1|ensembl:ENSMUSG00000043991(gene)|ensembl:ENSMUST00000051301(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:P42669	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:3LVZ5qdZYeJyeUVPhy3cozxROWs10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P63318	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-397096|uniprotkb:P05697|ensembl:ENSMUSP00000097874	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:kpcg_mouse(display_long)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_035232.1|ensembl:ENSMUSG00000078816(gene)|ensembl:ENSMUST00000100301(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0005829"(cytosol)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|interpro:IPR020454|interpro:IPR035892|mint:P63318|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-416993|reactome:R-MMU-5099900|reactome:R-MMU-76005	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P16054	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-298451|ensembl:ENSMUSP00000094873|ensembl:ENSMUSP00000094874	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:kpce_mouse(display_long)|uniprotkb:Prkce(gene name)|psi-mi:Prkce(display_short)|uniprotkb:Pkce(gene name synonym)|uniprotkb:Pkcea(gene name synonym)|uniprotkb:nPKC-epsilon(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000045038(gene)|ensembl:ENSMUST00000097274(transcript)|ensembl:ENSMUST00000097275(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027274|interpro:IPR034669|interpro:IPR035892|reactome:R-MMU-114508|reactome:R-MMU-1250196|reactome:R-MMU-1489509|reactome:R-MMU-2029485|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0005829"(cytosol)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035276"(ethanol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071944"(cell periphery)|go:"GO:0043278"(response to morphine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046872"(metal ion binding)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001031"(positive regulation of cellular glucuronidation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050996"(positive regulation of lipid catabolic process)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0051301"(cell division)|refseq:NP_035234.1|dip:DIP-31066N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:LBpr5ejW6fnkKwlXL6akJYv3H1M10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q9JIG8	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-16733287|ensembl:ENSMUSP00000033489	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:praf2_mouse(display_long)|uniprotkb:Praf2(gene name)|psi-mi:Praf2(display_short)|uniprotkb:DXImx39e(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000031149(gene)|ensembl:ENSMUST00000033489(transcript)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004895(Prenylated rab acceptor PRA1)|refseq:NP_613068.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:QoVpcIsrF3nsZnIdbqA+kNvViQU10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q3USB7	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-16733252|ensembl:ENSMUSP00000037854|uniprotkb:D3Z0W5|uniprotkb:Q3TSM9	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:plcl1_mouse(display_long)|uniprotkb:Phospholipase C-related but catalytically inactive protein(gene name synonym)|uniprotkb:Plcl1(gene name)|psi-mi:Plcl1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000038349(gene)|ensembl:ENSMUST00000042986(transcript)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR017946|interpro:IPR035892|interpro:IPR042124|mint:Q3USB7|refseq:NP_001108135.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:UH43D5ZRmFajncAe1RTEkeZ68Pk10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q99104	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-400199|uniprotkb:E9PUE5|ensembl:ENSMUSP00000116028	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:myo5a_mouse(display_long)|uniprotkb:Myo5a(gene name)|psi-mi:Myo5a(display_short)|uniprotkb:Dilute(gene name synonym)|uniprotkb:Dilute myosin heavy chain, non-muscle(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_034994.2|ensembl:ENSMUSG00000034593(gene)|ensembl:ENSMUST00000123128(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000149"(SNARE binding)|go:"GO:0001726"(ruffle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007601"(visual perception)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014046"(dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031585"(regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031982"(vesicle)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032433"(filopodium tip)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042476"(odontogenesis)|go:"GO:0042552"(myelination)|go:"GO:0042641"(actomyosin)|go:"GO:0042642"(actomyosin, myosin complex part)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043473"(pigmentation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0050808"(synapse organization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051643"(endoplasmic reticulum localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099089"(establishment of endoplasmic reticulum localization to postsynapse)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0099640"(axo-dendritic protein transport)|go:"GO:0150103"(reactive gliosis)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|go:"GO:0030318"(melanocyte differentiation)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR037988|mint:Q99104|rcsb pdb:2IX7|rcsb pdb:3WB8|rcsb pdb:4KP3|rcsb pdb:4ZLK|rcsb pdb:6KU0|reactome:R-MMU-2029482|interpro:IPR002710(Dilute)|go:"GO:0030141"(secretory granule)|dip:DIP-29542N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:8QtBlLL4DqB3An4CoCFVmvBEXBg10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q80TE7	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-774900	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:lrrc7_mouse(display_long)|uniprotkb:Protein LAP1(gene name synonym)|uniprotkb:Densin-180(gene name synonym)|uniprotkb:Lrrc7(gene name)|psi-mi:Lrrc7(display_short)|uniprotkb:Kiaa1365(gene name synonym)|uniprotkb:Lap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001278381.1|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR032675|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR036034|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6798695|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043194"(axon initial segment)|go:"GO:0043197"(dendritic spine)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:QWCdfe/eQM/ZaaAG2GwZi+Rf87Q10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q9JM63	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2309655|ensembl:ENSMUSP00000054356	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:kcj10_mouse(display_long)|uniprotkb:Kcnj10(gene name)|psi-mi:Kcnj10(display_short)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 10(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir4.1"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001034573.1|refseq:XP_006496740.2|ensembl:ENSMUSG00000044708(gene)|ensembl:ENSMUST00000056136(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0044297"(cell body)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051935"(glutamate reuptake)|go:"GO:0051938"(L-glutamate import)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097546"(ciliary base)|go:"GO:0098793"(presynapse)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR003269(Potassium channel, inwardly rectifying, Kir1.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:Q9JM63|reactome:R-MMU-1296041|reactome:R-MMU-1296067|reactome:R-MMU-997272	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:xYsrr3gfPI6Dob9k78XGFz3Pp2410090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P62482	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-771096|uniprotkb:P97381|uniprotkb:Q60942|uniprotkb:Q64284|ensembl:ENSMUSP00000101273|ensembl:ENSMUSP00000125058	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:kcab2_mouse(display_long)|uniprotkb:"K(+) channel subunit beta-2"(gene name synonym)|uniprotkb:Kv-beta-2(gene name synonym)|uniprotkb:Neuroimmune protein F5(gene name synonym)|uniprotkb:Kcnab2(gene name)|psi-mi:Kcnab2(display_short)|uniprotkb:Ckbeta2(gene name synonym)|uniprotkb:I2rf5(gene name synonym)|uniprotkb:Kcnb3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_034728.2|refseq:XP_017175485.1|refseq:NP_001239585.1|ensembl:ENSMUSG00000028931(gene)|ensembl:ENSMUST00000105648(transcript)|ensembl:ENSMUST00000160884(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004033"("aldo-keto reductase (NADP) activity")|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0030424"(axon)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034705"(potassium channel complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|go:"GO:0050905"(neuromuscular process)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0098900"(regulation of action potential)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1990031"(pinceau fiber)|go:"GO:2000008"(regulation of protein localization to cell surface)|interpro:IPR005399(Potassium channel, voltage-dependent, beta subunit, KCNAB-related)|interpro:IPR005401(Potassium channel, voltage-dependent, beta subunit, KCNAB2)|interpro:IPR005983(Potassium channel, voltage-dependent, beta subunit, KCNAB)|interpro:IPR023210|interpro:IPR036812|mint:P62482|reactome:R-MMU-1296072|reactome:R-MMU-6798695	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:ZWu/Ez0ginUniSAUbIGXgod3iqg10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q61423	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2309633|uniprotkb:Q8CBF8|ensembl:ENSMUSP00000037958	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:kcna4_mouse(display_long)|uniprotkb:Kcna4(gene name)|psi-mi:Kcna4(display_short)|uniprotkb:Voltage-gated potassium channel subunit Kv1.4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_067250.2|refseq:XP_006498875.1|ensembl:ENSMUSG00000042604(gene)|ensembl:ENSMUST00000037012(transcript)|go:"GO:0005216"(ion channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR012897(Potassium channel, voltage dependent, Kv1.4, tandem inactivation)|interpro:IPR020467|interpro:IPR027359|interpro:IPR028325|interpro:IPR037065|reactome:R-MMU-1296072	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:kLzL2QUiIqbJX3FwQ8RNPL9rxac10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:A2CG49	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-770321|uniprotkb:A2CG50|uniprotkb:A2CG51|uniprotkb:A2CG52|uniprotkb:A2CG53|uniprotkb:Q3TYL1|uniprotkb:Q3UTA5|uniprotkb:Q8BTT9|uniprotkb:Q8C4Q2|uniprotkb:Q9CVA9|uniprotkb:Q3TXY8|uniprotkb:B2RXR5|uniprotkb:D3Z559|ensembl:ENSMUSP00000076088	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:kalrn_mouse(display_long)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001157740.1|refseq:XP_006522445.1|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018159|interpro:IPR028570|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSMUSG00000061751(gene)|ensembl:ENSMUST00000076810(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0035176"(social behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042711"(maternal behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046959"(habituation)|mint:A2CG49|rcsb pdb:1WFW|reactome:R-MMU-193648|reactome:R-MMU-3928662|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5687128|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013408|interpro:IPR036865	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:pDqdA2QNbqgLE3eYQXVVW2cxIyo10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q5DU25	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-773452|uniprotkb:E9QK46	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:iqec2_mouse(display_long)|uniprotkb:Iqsec2(gene name)|psi-mi:Iqsec2(display_short)|uniprotkb:Kiaa0522(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000904(SEC7-like)|interpro:IPR023394|interpro:IPR033742|refseq:XP_006528908.1|interpro:IPR035999|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900454"(positive regulation of long-term synaptic depression)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:D2kDV/pgwPkXPHcK5+7S9+HS6Wk10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q8R0S2	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-772277|uniprotkb:Q3TZC3|uniprotkb:Q5DU15|ensembl:ENSMUSP00000098712	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:iqec1_mouse(display_long)|uniprotkb:Iqsec1(gene name)|psi-mi:Iqsec1(display_short)|uniprotkb:Kiaa0763(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001127855.1|ensembl:ENSMUSG00000034312(gene)|ensembl:ENSMUST00000101153(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR030737|interpro:IPR033742|interpro:IPR035999	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:BZg7CaLndE4ak8KXs34YFf9iBRQ10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q9Z2Y3	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q03391	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2309422|uniprotkb:C9K0Z5|ensembl:ENSMUSP00000002848|ensembl:ENSMUSP00000147663	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:nmde4_mouse(display_long)|uniprotkb:Grin2d(gene name)|psi-mi:Grin2d(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2D(gene name synonym)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-4(gene name synonym)|uniprotkb:GluN2D(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:XP_011249107.1|refseq:NP_032198.2|ensembl:ENSMUSG00000002771(gene)|ensembl:ENSMUST00000002848(transcript)|ensembl:ENSMUST00000211713(transcript)|go:"GO:0001964"(startle response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0045202"(synapse)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:Q03391|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:SJwi1VKUdtgh3l6xcUxHm/57loU10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q01097	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-400125|uniprotkb:Q9DCB2	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P35436	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-400115|ensembl:ENSMUSP00000032331|ensembl:ENSMUSP00000111501|ensembl:ENSMUSP00000142900	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:nmde1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:Grin2a(gene name)|psi-mi:Grin2a(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_032196.2|reactome:R-MMU-8849932|reactome:R-MMU-9609736|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-438066|go:"GO:0098839"(postsynaptic density membrane)|ensembl:ENSMUSG00000059003(gene)|ensembl:ENSMUST00000032331(transcript)|ensembl:ENSMUST00000115835(transcript)|ensembl:ENSMUST00000199708(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040011"(locomotion)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|refseq:XP_006521857.1|dip:DIP-31567N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:5DMFDOh6NuFArDtKp2gp2IpmhWQ10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P35438	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q9Z2W9	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-445507|uniprotkb:A2VDF4|uniprotkb:Q5DTJ0|ensembl:ENSMUSP00000075687	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:gria3_mouse(display_long)|uniprotkb:GluR-K3(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 3(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 3(gene name synonym)|uniprotkb:Gria3(gene name)|psi-mi:Gria3(display_short)|uniprotkb:Kiaa4184(gene name synonym)|uniprotkb:Glur3(gene name synonym)|uniprotkb:GluR-C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_058582.3|refseq:XP_006541583.1|refseq:NP_001268858.1|refseq:XP_017174034.1|ensembl:ENSMUSG00000001986(gene)|ensembl:ENSMUST00000076349(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032991"(protein-containing complex)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|go:"GO:0038023"(signaling receptor activity)|interpro:IPR028082|go:"GO:0043025"(neuronal cell body)|mint:Q9Z2W9|rcsb pdb:3LSW|rcsb pdb:3LSX|go:"GO:0043083"(synaptic cleft)|reactome:R-MMU-399710|reactome:R-MMU-399719|reactome:R-MMU-416993|go:"GO:0043195"(terminal bouton)|reactome:R-MMU-438066|go:"GO:0043197"(dendritic spine)|reactome:R-MMU-8849932|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:n9Lnq/kl4co4Th5d/N5JX+cN4yU10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P23819	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-77538|uniprotkb:Q61604|uniprotkb:Q61605|uniprotkb:Q8BG69|uniprotkb:Q8BXU3|uniprotkb:Q9D6D3	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:gria2_mouse(display_long)|uniprotkb:Gria2(gene name)|psi-mi:Gria2(display_short)|uniprotkb:Glur2(gene name synonym)|uniprotkb:GluR-B(gene name synonym)|uniprotkb:GluR-K2(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 2(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051117"(ATPase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|reactome:R-MMU-399710|reactome:R-MMU-416993|reactome:R-MMU-438066|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR028082|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|mint:P23819	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:v71xzThz9kadLOPBasVAc1y/FXs10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P23818	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-445486|ensembl:ENSMUSP00000044494	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:gria1_mouse(display_long)|uniprotkb:GluR-A(gene name synonym)|uniprotkb:GluR-K1(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 1(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 1(gene name synonym)|uniprotkb:Gria1(gene name)|psi-mi:Gria1(display_short)|uniprotkb:Glur1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001106796.1|dip:DIP-31970N|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044297"(cell body)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060076"(excitatory synapse)|go:"GO:0045202"(synapse)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:7LDD|rcsb pdb:7LDE|reactome:R-MMU-204005|reactome:R-MMU-399710|reactome:R-MMU-399719|reactome:R-MMU-416993|ensembl:ENSMUSG00000020524(gene)|ensembl:ENSMUST00000036315(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|reactome:R-MMU-438066|reactome:R-MMU-5694530|reactome:R-MMU-8849932	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:5hAcAV1UEfdgn7CNrrAHPIwUs/410090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P18872	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-771950|uniprotkb:P18873|intact:EBI-1018769|ensembl:ENSMUSP00000034198|ensembl:ENSMUSP00000114144	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:gnao_mouse(display_long)|uniprotkb:Gnao1(gene name)|psi-mi:Gnao1(display_short)|uniprotkb:Gna0(gene name synonym)|uniprotkb:Gnao(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001106855.1|refseq:NP_034438.1|dip:DIP-29921N|ensembl:ENSMUSG00000031748(gene)|ensembl:ENSMUST00000034198(transcript)|ensembl:ENSMUST00000125716(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009987"(cellular process)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P18872|rcsb pdb:3C7K|reactome:R-MMU-4086398	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:CCww9l5owYxGicswRXjsSu6Y+5g10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P15105	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-444858|uniprotkb:Q3TRK7|uniprotkb:Q64432|uniprotkb:Q91VC6|ensembl:ENSMUSP00000083375|ensembl:ENSMUSP00000123157	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:glna_mouse(display_long)|uniprotkb:Glutamate--ammonia ligase(gene name synonym)|uniprotkb:Glul(gene name)|psi-mi:Glul(display_short)|uniprotkb:Glns(gene name synonym)|uniprotkb:Palmitoyltransferase GLUL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_032157.2|go:"GO:0030145"(manganese ion binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0097386"(glial cell projection)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR008146(Glutamine synthetase, catalytic region)|interpro:IPR008147(Glutamine synthetase, beta-Grasp)|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR027302|interpro:IPR027303|interpro:IPR036651|mint:P15105|reactome:R-MMU-210455|reactome:R-MMU-8964539|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|ensembl:ENSMUSG00000026473(gene)|ensembl:ENSMUST00000086199(transcript)|ensembl:ENSMUST00000140685(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0004356"(glutamate-ammonia ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006542"(glutamine biosynthetic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0016595"(glutamate binding)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019676"(ammonia assimilation cycle)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:j6R9fxGLKpiREWpecpdnBY9ftoo10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q9R111	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2308876|ensembl:ENSMUSP00000084882	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:guad_mouse(display_long)|uniprotkb:Gda(gene name)|psi-mi:Gda(display_short)|uniprotkb:Guanine aminohydrolase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_034396.1|ensembl:ENSMUSG00000058624(gene)|ensembl:ENSMUST00000087600(transcript)|go:"GO:0000255"(allantoin metabolic process)|go:"GO:0005829"(cytosol)|go:"GO:0006147"(guanine catabolic process)|go:"GO:0006161"(deoxyguanosine catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008892"(guanine deaminase activity)|go:"GO:0019239"(deaminase activity)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0046055"(dGMP catabolic process)|go:"GO:0046098"(guanine metabolic process)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR014311(Guanine deaminase)|interpro:IPR032466|mint:Q9R111|reactome:R-MMU-74259|go:"GO:0046038"(GMP catabolic process)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:4GljtxkNduzgstV1OX/vkPJ/Qvg10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q80UW2	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2314714|uniprotkb:Q8R0D2|ensembl:ENSMUSP00000037377	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:fbx2_mouse(display_long)|uniprotkb:Fbs1(gene name synonym)|uniprotkb:Fbxo2(gene name)|psi-mi:Fbxo2(display_short)|uniprotkb:Fbx2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_789818.1|refseq:XP_006538877.1|dip:DIP-54758N|ensembl:ENSMUSG00000041556(gene)|ensembl:ENSMUST00000047951(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0043197"(dendritic spine)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR007397(F-box associated region)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036047|interpro:IPR039752|rcsb pdb:1UMH|rcsb pdb:1UMI|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2E33|rcsb pdb:2RJ2|rcsb pdb:5B4N|reactome:R-MMU-8951664|reactome:R-MMU-983168	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:MFGKJfNmB58nx1Ij634RZe95br010090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q3UXZ6	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2308826|uniprotkb:Q8BQV1|uniprotkb:Q8C548|uniprotkb:Q8R3B5|uniprotkb:Q9D369|ensembl:ENSMUSP00000034749	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:fa81a_mouse(display_long)|uniprotkb:Fam81a(gene name)|psi-mi:Fam81a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_084060.1|refseq:XP_006511613.1|refseq:XP_006511614.1|ensembl:ENSMUSG00000032224(gene)|ensembl:ENSMUST00000034749(transcript)|interpro:IPR029619|interpro:IPR029622	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:B2gqwbO+APP0oh2e0om4bCpv7UM10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:O70318	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-643339|uniprotkb:G3X9B8|ensembl:ENSMUSP00000055122|ensembl:ENSMUSP00000090314	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:e41l2_mouse(display_long)|uniprotkb:Generally expressed protein 4.1(gene name synonym)|uniprotkb:Epb41l2(gene name)|psi-mi:Epb41l2(display_short)|uniprotkb:Epb4.1l2(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_038539.2|refseq:NP_001186194.1|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0005654"(nucleoplasm)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030507"(spectrin binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0051301"(cell division)|go:"GO:0099738"(cell cortex region)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030546|interpro:IPR035963|mint:O70318|reactome:R-MMU-6794361|ensembl:ENSMUSG00000019978(gene)|ensembl:ENSMUST00000053748(transcript)|ensembl:ENSMUST00000092645(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:4hNttT3WQk43puSMmOdjpNS8oUo10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q9JHU4	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-645061|uniprotkb:E9QM71|ensembl:ENSMUSP00000018851	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dyhc1_mouse(display_long)|uniprotkb:Dhc1(gene name synonym)|uniprotkb:Dyhc(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:Dync1h1(gene name)|psi-mi:Dync1h1(display_short)|uniprotkb:Dnch1(gene name synonym)|uniprotkb:Dnchc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_084514.2|ensembl:ENSMUSG00000018707(gene)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002177"(manchette)|go:"GO:0003341"(cilium movement)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|ensembl:ENSMUST00000018851(transcript)|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|interpro:IPR042219|mint:Q9JHU4|rcsb pdb:3ERR|rcsb pdb:3J1T|rcsb pdb:3J1U|rcsb pdb:3WUQ|rcsb pdb:5AYH|rcsb pdb:6RZA|rcsb pdb:6RZB|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:sbED0xqQpe32T7I8ijeS3Xqlx7010090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:O08553	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-446064|uniprotkb:Q6P5D0|ensembl:ENSMUSP00000022629	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dpyl2_mouse(display_long)|uniprotkb:Unc-33-like phosphoprotein 2(gene name synonym)|uniprotkb:Dpysl2(gene name)|psi-mi:Dpysl2(display_short)|uniprotkb:Crmp2(gene name synonym)|uniprotkb:Ulip2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_034085.2|ensembl:ENSMUSG00000022048(gene)|ensembl:ENSMUST00000022629(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043209"(myelin sheath)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098793"(presynapse)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030615|interpro:IPR032466|mint:O08553|rcsb pdb:5UQC|reactome:R-MMU-399956|reactome:R-MMU-437239	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:97yc8TNEPMcGtGNRLvl+KV+DYr010090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q8BPN8	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-6272744|ensembl:ENSMUSP00000113693|uniprotkb:B0V2P4|uniprotkb:Q3TNY5|uniprotkb:Q69ZX5|uniprotkb:Q8CCU3	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dmxl2_mouse(display_long)|uniprotkb:Dmxl2(gene name)|psi-mi:Dmxl2(display_short)|uniprotkb:Kiaa0856(gene name synonym)|uniprotkb:Rabconnectin-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000041268(gene)|ensembl:ENSMUST00000118600(transcript)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043291"(RAVE complex)|go:"GO:0098992"(neuronal dense core vesicle)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR022033|interpro:IPR036322|mint:Q8BPN8|go:"GO:0007283"(spermatogenesis)|refseq:XP_006511148.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:6uQuMnUYqGc8AF3fTtUWEHX2Z1w10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:B1AZP2	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-645637|uniprotkb:B1AZP3|uniprotkb:Q3KQQ8|uniprotkb:Q6PD44|uniprotkb:Q6XBF1|uniprotkb:Q80TN3|uniprotkb:Q8R3U9|uniprotkb:B7ZNS1|ensembl:ENSMUSP00000126980	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dlgp4_mouse(display_long)|uniprotkb:Kiaa0964(gene name synonym)|uniprotkb:Sapap4(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 4(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 4(gene name synonym)|uniprotkb:Dlgap4(gene name)|psi-mi:Dlgap4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001035952.1|refseq:NP_666240.4|refseq:NP_001264115.1|refseq:NP_001035953.1|refseq:NP_001264116.1|refseq:XP_006499403.1|ensembl:ENSMUSG00000061689(gene)|ensembl:ENSMUST00000169464(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023052"(signaling)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030527|mint:B1AZP2|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:Ksjp5jiwjvzSymdyt1kSs8I+1pE10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q6PFD5	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2308733|uniprotkb:Q6PDX0|uniprotkb:Q6XBF2|ensembl:ENSMUSP00000039724|ensembl:ENSMUSP00000101700	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dlgp3_mouse(display_long)|uniprotkb:Dlgap3(gene name)|psi-mi:Dlgap3(display_short)|uniprotkb:Dap3(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 3(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:XP_011238839.1|refseq:NP_941020.1|refseq:NP_001289010.1|ensembl:ENSMUSG00000042388(gene)|ensembl:ENSMUST00000046659(transcript)|ensembl:ENSMUST00000106094(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023052"(signaling)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030526|mint:Q6PFD5|rcsb pdb:5IZU|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:mkXYwYR5Snou4RA8d71UDC7G59I10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q8BJ42	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-2308675|uniprotkb:Q6XBF3|ensembl:ENSMUSP00000039647|ensembl:ENSMUSP00000119613	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dlgp2_mouse(display_long)|uniprotkb:Dlgap2(gene name)|psi-mi:Dlgap2(display_short)|uniprotkb:Dap2(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 2(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_001139437.1|refseq:NP_766498.2|refseq:XP_017168275.1|ensembl:ENSMUSG00000047495(gene)|ensembl:ENSMUST00000043279(transcript)|ensembl:ENSMUST00000133298(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0043197"(dendritic spine)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030525|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:9V3GlRM3AupA70mmFtZ4biXuC9E10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q9D415	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q62108	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:P70175	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-396969|ensembl:ENSMUSP00000085299	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dlg3_mouse(display_long)|uniprotkb:Dlg3(gene name)|psi-mi:Dlg3(display_short)|uniprotkb:Dlgh3(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_058027.1|refseq:NP_001171249.1|ensembl:ENSMUSG00000000881(gene)|ensembl:ENSMUST00000087984(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|mint:P70175|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-6794361|reactome:R-MMU-8849932|dip:DIP-31585N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:9dR9P876v8QcvPinxtaWzDgpHwE10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q91XM9	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-400138|uniprotkb:Q8BXK7|uniprotkb:Q8BYG5|ensembl:ENSMUSP00000102814|uniprotkb:F8VQM7	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dlg2_mouse(display_long)|uniprotkb:Dlg2(gene name)|psi-mi:Dlg2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	ensembl:ENSMUSG00000052572(gene)|ensembl:ENSMUST00000107196(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035759|interpro:IPR036028|interpro:IPR036034|mint:Q91XM9|rcsb pdb:2WL7|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6794361|refseq:NP_001229976.1|refseq:NP_035937.2|dip:DIP-31569N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:37/IFbjDNxh87dnN2gglIgDGyIU10090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F6SEU4	uniprotkb:Q811D0	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-514290|uniprotkb:Q62402|uniprotkb:Q6PGB5|uniprotkb:Q8CGN7|ensembl:ENSMUSP00000097581|ensembl:ENSMUSP00000110859	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dlg1_mouse(display_long)|uniprotkb:Synapse-associated protein 97(gene name synonym)|uniprotkb:Embryo-dlg/synapse-associated protein 97(gene name synonym)|uniprotkb:Dlg1(gene name)|psi-mi:Dlg1(display_short)|uniprotkb:Dlgh1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16733301|imex:IM-26285-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_031888.2|refseq:NP_001239362.1|refseq:NP_001239364.1|refseq:XP_006521831.1|refseq:NP_001239363.1|dip:DIP-31591N|ensembl:ENSMUSG00000022770(gene)|ensembl:ENSMUST00000100001(transcript)|ensembl:ENSMUST00000115205(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034629"|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043219"(lateral loop)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060022"(hard palate development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1902473"(regulation of protein localization to synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903286"(regulation of potassium ion import)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903760"(regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:1903764"(regulation of potassium ion export across plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR015143(L27-1)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q811D0|rcsb pdb:4OAJ|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-8849932	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:b8LjYbiuR2K6/jxhwU1hxBJKX6410090	rigid:7qUfXT1NiTBif62ddeXLVqYuS78	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P26041	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8322611|uniprotkb:Q8BSN4|intact:MINT-1866505|uniprotkb:B1AX70|uniprotkb:Q3UL28|ensembl:ENSMUSP00000113071	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:moes_mouse(display_long)|uniprotkb:Msn(gene name)|psi-mi:Msn(display_short)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_034963.2|ensembl:ENSMUSG00000031207(gene)|ensembl:ENSMUST00000117399(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043209"(myelin sheath)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26041|reactome:R-MMU-437239|rcsb pdb:4YL8	-	-	function:Probably involved in connections of major cytoskeletal structures to the plasma membrane|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:Oy6Ki6PiaAzF58D07s8b5V42/dw10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P21619	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8340638|intact:MINT-4100052|uniprotkb:P48680|uniprotkb:Q8CGB1|ensembl:ENSMUSP00000136524	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:lmnb2_mouse(display_long)|uniprotkb:Lmnb2(gene name)|psi-mi:Lmnb2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001334069.1|refseq:NP_034852.2|ensembl:ENSMUSG00000062075(gene)|ensembl:ENSMUST00000179022(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P21619	-	-	function:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:s8kNScxQWheNZ5Yu1h/5R+lvb9I10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9WVR4	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8572772|uniprotkb:Q9WVR5|intact:UNK-5560063	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:fxr2_mouse(display_long)|uniprotkb:Fxr2(gene name)|psi-mi:Fxr2(display_short)|uniprotkb:Fxr2h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	interpro:IPR032172|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0045182"(translation regulator activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR022034|interpro:IPR008395(Agenet)|interpro:IPR004088(K Homology, type 1)|interpro:IPR040472|interpro:IPR040148|interpro:IPR036612|interpro:IPR041560	-	-	function:RNA-binding protein|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:q56uykuU0MnJ8r9/CdCuFG+ML0M10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6A0A9	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8327719|intact:MINT-1858841|uniprotkb:Q91Z16|uniprotkb:B3DFJ0|uniprotkb:A0PJK6|ensembl:ENSMUSP00000053877	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:f120a_mouse(display_long)|uniprotkb:Kiaa0183(gene name synonym)|uniprotkb:Ossa(gene name synonym)|uniprotkb:Oxidative stress-associated Src activator(gene name synonym)|uniprotkb:Protein FAM120A(gene name synonym)|uniprotkb:FAM120A(gene name)|psi-mi:FAM120A(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001028440.2|ensembl:ENSMUSG00000038014(gene)|ensembl:ENSMUST00000060805(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR026784|interpro:IPR029060|mint:Q6A0A9	-	-	comment:"fragmentation type: fragment"|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:tZj0TOhfuvvF4GaEPHI7jWpKyl810090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q61701	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8339146|uniprotkb:A2A9R6|uniprotkb:A2A9R8|uniprotkb:A2A9S0|uniprotkb:A2A9S1|uniprotkb:A2A9S2|uniprotkb:A2A9S3|uniprotkb:Q6PHZ3|uniprotkb:Q8BVA9|intact:MINT-4094262|uniprotkb:O55010|uniprotkb:A2A9R7|ensembl:ENSMUSP00000102207	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:elav4_mouse(display_long)|uniprotkb:Elavl4(gene name)|psi-mi:Elavl4(display_short)|uniprotkb:Hud(gene name synonym)|uniprotkb:Paraneoplastic encephalomyelitis antigen HuD(gene name synonym)|uniprotkb:Hu-antigen D(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001033787.1|refseq:NP_034618.2|refseq:NP_001334107.1|refseq:XP_006502862.1|ensembl:ENSMUSG00000028546(gene)|ensembl:ENSMUST00000106597(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008306"(associative learning)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031099"(regeneration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0097158"(pre-mRNA intronic pyrimidine-rich binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1905870"(positive regulation of 3'-UTR-mediated mRNA stabilization)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034918|interpro:IPR035979|mint:Q61701	-	-	function:May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:HXthuBphfQOW5EWQAG1smb8ljZY10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q60900	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8322932|uniprotkb:Q60901|intact:MINT-4094236|ensembl:ENSMUSP00000003501	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:elav3_mouse(display_long)|uniprotkb:Elavl3(gene name)|psi-mi:Elavl3(display_short)|uniprotkb:Huc(gene name synonym)|uniprotkb:Hu-antigen C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_034617.1|refseq:XP_006510085.1|ensembl:ENSMUSG00000003410(gene)|ensembl:ENSMUST00000003501(transcript)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034915|interpro:IPR035979|mint:Q60900|rcsb pdb:1D8Z|rcsb pdb:1D9A|rcsb pdb:1FNX	-	-	function:May be involved in neuronal differentiation and maintenance|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:qUvIDm1H0L+uyA+cVP6Kjefc2N810090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q60899	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8329853|intact:MINT-4094224|ensembl:ENSMUSP00000008633	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:elav2_mouse(display_long)|uniprotkb:Elavl2(gene name)|psi-mi:Elavl2(display_short)|uniprotkb:Hub(gene name synonym)|uniprotkb:Hu-antigen B(gene name synonym)|uniprotkb:ELAV-like neuronal protein 1(gene name synonym)|uniprotkb:Nervous system-specific RNA-binding protein Mel-N1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_034616.1|refseq:XP_006502852.1|refseq:XP_006502853.1|refseq:XP_006502854.1|ensembl:ENSMUSG00000008489(gene)|ensembl:ENSMUST00000008633(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0045202"(synapse)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034914|interpro:IPR034999|interpro:IPR035979|mint:Q60899|reactome:R-MMU-72163	-	-	comment:mint|function:Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:dgDCiu1mN8mz6K95+ihBGQY8K8k10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q64318	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8560245|uniprotkb:A4QPD2|intact:UNK-5466074|uniprotkb:Q62519|ensembl:ENSMUSP00000025081	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:zeb1_mouse(display_long)|uniprotkb:Zeb1(gene name)|psi-mi:Zeb1(display_short)|uniprotkb:Tcf8(gene name synonym)|uniprotkb:Zfhx1a(gene name synonym)|uniprotkb:Zfx1a(gene name synonym)|uniprotkb:Zfx1ha(gene name synonym)|uniprotkb:Transcription factor 8(gene name synonym)|uniprotkb:Zinc finger homeobox protein 1a(gene name synonym)|uniprotkb:Delta EF1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_035676.1|dip:DIP-60280N|ensembl:ENSMUSG00000024238(gene)|ensembl:ENSMUST00000025081(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007389"(pattern specification process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010464"(regulation of mesenchymal cell proliferation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048513"(animal organ development)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0070888"(E-box binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090103"(cochlea morphogenesis)|interpro:IPR001356(Homeobox)|interpro:IPR008598(Drought induced 19)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q64318	-	-	comment:mint|function:Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:WZxQkmepgvyAByjcomRjaQ9RaBg10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8CGF6	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8316986|intact:MINT-4140349|uniprotkb:Q80TP4|uniprotkb:A2AGC7|ensembl:ENSMUSP00000057482	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:wdr47_mouse(display_long)|uniprotkb:Wdr47(gene name)|psi-mi:Wdr47(display_short)|uniprotkb:Kiaa0893(gene name synonym)|uniprotkb:Neuronal enriched MAP interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_852065.2|refseq:XP_017175308.1|dip:DIP-58945N|ensembl:ENSMUSG00000040389(gene)|ensembl:ENSMUST00000051145(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR036322|interpro:IPR040067|mint:Q8CGF6	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:t4myqVx9Xs1MBbib6vp11Wylu9Y10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q99KW3	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8400475|uniprotkb:Q2Q402|uniprotkb:Q8CG90|intact:MINT-4136918|uniprotkb:Q2Q404|uniprotkb:Q2Q403|uniprotkb:Q8C6T3|uniprotkb:Q6ZPK4|uniprotkb:Q2PZW9|ensembl:ENSMUSP00000105312	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:tara_mouse(display_long)|uniprotkb:Triobp(gene name)|psi-mi:Triobp(display_short)|uniprotkb:Kiaa1662(gene name synonym)|uniprotkb:Tara(gene name synonym)|uniprotkb:Protein Tara(gene name synonym)|uniprotkb:Trio-associated repeat on actin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_613045.3|refseq:NP_001034245.1|refseq:NP_001034244.1|refseq:XP_017171854.1|ensembl:ENSMUSG00000033088(gene)|ensembl:ENSMUST00000109690(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051301"(cell division)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0120044"(stereocilium base)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039597|mint:Q99KW3	-	-	comment:mint|function:May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:r9uopYJSBWl4d17NUAJiB5IJY7U10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q61818	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8357942|uniprotkb:Q8CEV1|uniprotkb:Q6ZPH7|uniprotkb:B1AU87|intact:MINT-4131713|ensembl:ENSMUSP00000070896|ensembl:ENSMUSP00000099749|ensembl:ENSMUSP00000126183	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:rai1_mouse(display_long)|uniprotkb:Rai1(gene name)|psi-mi:Rai1(display_short)|uniprotkb:Kiaa1820(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_033047.2|refseq:NP_001032853.1|ensembl:ENSMUSG00000062115(gene)|ensembl:ENSMUST00000064190(transcript)|ensembl:ENSMUST00000102688(transcript)|ensembl:ENSMUST00000171108(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|mint:Q61818	-	-	function:May function as a transcriptional regulator. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:j9wiUBlT7kIxyGFlhvWkXHLiry810090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6P9L6	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8586561|ensembl:ENSMUSP00000035490|uniprotkb:Q70MX5|uniprotkb:O35065|intact:UNK-5482037	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kif15_mouse(display_long)|uniprotkb:Klp2(gene name synonym)|uniprotkb:Knsl7(gene name synonym)|uniprotkb:Kinesin-like protein 2(gene name synonym)|uniprotkb:Kinesin-like protein 7(gene name synonym)|uniprotkb:Kif15(gene name)|psi-mi:Kif15(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000036768(gene)|ensembl:ENSMUST00000040717(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR031794|interpro:IPR036961|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189|refseq:NP_034750.1	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:apHySN9WwHHX9Qh/HQGQbfPA22E10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q7TPV2	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8372821|uniprotkb:Q8BYK7|uniprotkb:Q80TU4|intact:MINT-4093781|uniprotkb:Q148V3	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:dzip3_mouse(display_long)|uniprotkb:Dzip3(gene name)|psi-mi:Dzip3(display_short)|uniprotkb:Kiaa0675(gene name synonym)|uniprotkb:DAZ-interacting protein 3 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DZIP3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	interpro:IPR033103|refseq:NP_081617.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPV2|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR041249|interpro:IPR043866|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-MMU-983168	-	-	comment:mint|function:E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:Af5+nqZi0f8/jHDg+JzgOVOB0ic10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6VGS5	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-7696187|ensembl:ENSMUSP00000068629|intact:MINT-1890259|uniprotkb:Q3UVI2	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:daple_mouse(display_long)|uniprotkb:Ccdc88c(gene name)|psi-mi:Ccdc88c(display_short)|uniprotkb:Daple(gene name synonym)|uniprotkb:Dvl-associating protein with a high frequency of leucine residues(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 88C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000021182(gene)|ensembl:ENSMUST00000068411(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003383"(apical constriction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031648"(protein destabilization)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR027719|interpro:IPR036872|interpro:IPR043936|refseq:NP_080957.2	-	-	comment:mint|function:Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:N8Lb/xi0N2NeqnqNU6XsiAVdtWg10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9D8X2	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8373063|uniprotkb:Q8C2T0|intact:MINT-4127701|ensembl:ENSMUSP00000007865	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:cc124_mouse(display_long)|uniprotkb:Ccdc124(gene name)|psi-mi:Ccdc124(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_081240.1|refseq:XP_006509718.1|ensembl:ENSMUSG00000007721(gene)|ensembl:ENSMUST00000007865(transcript)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0030496"(midbody)|go:"GO:0051301"(cell division)|interpro:IPR010422(Protein of unknown function DUF1014)|mint:Q9D8X2	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:PysPYw5qRD0Khqr9W6d5JDpPSok10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:A2AHC3	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8315846|ensembl:ENSMUSP00000088812|ensembl:ENSMUSP00000139028|uniprotkb:Q7TQF8|intact:MINT-4115002|uniprotkb:Q8CBV3	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:camp1_mouse(display_long)|uniprotkb:Camsap1(gene name)|psi-mi:Camsap1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000026933(gene)|ensembl:ENSMUST00000091268(transcript)|ensembl:ENSMUST00000183461(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030507"(spectrin binding)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0051011"(microtubule minus-end binding)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011033(PRC-barrel-like)|interpro:IPR014797(Protein of unknown function DUF1781)|interpro:IPR022613|interpro:IPR031372|interpro:IPR032940|interpro:IPR038209|mint:A2AHC3|interpro:IPR036872|refseq:NP_001263288.1|refseq:NP_001263290.1|refseq:NP_001263289.1	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:+1co+J8WhfPuX8PMFq2C2m1Wm7o10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P83510	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	-	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q3UTJ2	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8345744|uniprotkb:Q80TS1|intact:MINT-1853612|uniprotkb:Q3USC6|uniprotkb:Q8BX47|uniprotkb:Q8CHU0|uniprotkb:Q8BLW9|intact:MINT-4116161|uniprotkb:Q8BJL6|uniprotkb:Q8BJU3	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:srbs2_mouse(display_long)|uniprotkb:Sorbs2(gene name)|psi-mi:Sorbs2(display_short)|uniprotkb:Arg/Abl-interacting protein 2(gene name synonym)|uniprotkb:Argbp2(gene name synonym)|uniprotkb:Kiaa0777(gene name synonym)|uniprotkb:Arg-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001297636.1|interpro:IPR003127(Sorbin-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR028506|interpro:IPR036028|mint:Q3UTJ2|refseq:XP_006509449.1|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR001452(Src homology-3)	-	-	comment:"fragmentation type: fragment"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:2sKDQux/2IV7mW8l6LK36D3qlqw10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9Z2H2	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8320673|uniprotkb:Q08AT5|intact:MINT-4132316|uniprotkb:Q8BGI8|ensembl:ENSMUSP00000139735|ensembl:ENSMUSP00000143801|ensembl:ENSMUSP00000143961	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:rgs6_mouse(display_long)|uniprotkb:Rgs6(gene name)|psi-mi:Rgs6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001297407.1|refseq:NP_056627.1|refseq:NP_001268990.1|ensembl:ENSMUSG00000021219(gene)|ensembl:ENSMUST00000186458(transcript)|ensembl:ENSMUST00000200911(transcript)|ensembl:ENSMUST00000202210(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045666"(positive regulation of neuron differentiation)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|interpro:IPR037956|interpro:IPR040759|mint:Q9Z2H2|reactome:R-MMU-418594|reactome:R-MMU-6814122	-	-	function:"Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer"|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:xYjxZWDDzzkRX/rdp8SH4sdfGWk10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P80560	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8538944|uniprotkb:P70328|uniprotkb:Q1RLJ1|intact:MINT-8310377|uniprotkb:O09134|ensembl:ENSMUSP00000064046	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ptpr2_mouse(display_long)|uniprotkb:Phogrin(gene name synonym)|uniprotkb:Protein tyrosine phosphatase-NP(gene name synonym)|uniprotkb:Ptprn2(gene name)|psi-mi:Ptprn2(display_short)|uniprotkb:PTP IA-2beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_035345.2|ensembl:ENSMUSG00000056553(gene)|ensembl:ENSMUST00000070733(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043235"(receptor complex)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|reactome:R-MMU-6798695	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:4Jw+Bh/t4Q1Z67SgT6vJzrO05SM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8R4H2	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8046267|intact:MINT-1774761|uniprotkb:E9QPW9|uniprotkb:Q80U18|ensembl:ENSMUSP00000072547	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:arhgc_mouse(display_long)|uniprotkb:Arhgef12(gene name)|psi-mi:Arhgef12(display_short)|uniprotkb:Kiaa0382(gene name synonym)|uniprotkb:Larg(gene name synonym)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:XP_006510649.1|ensembl:ENSMUSG00000059495(gene)|ensembl:ENSMUST00000072767(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|mint:Q8R4H2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148	-	-	comment:mint|function:"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:5ZclDYjaUBilqiB548/6M5KlhVg10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q811P8	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-6949116|ensembl:ENSMUSP00000133898|intact:MINT-268399|uniprotkb:B9EHJ8|uniprotkb:Q6A010	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:rhg32_mouse(display_long)|uniprotkb:RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling(gene name synonym)|uniprotkb:Rics(gene name synonym)|uniprotkb:p200RhoGAP(gene name synonym)|uniprotkb:p250GAP(gene name synonym)|uniprotkb:Arhgap32(gene name)|psi-mi:Arhgap32(display_short)|uniprotkb:Brain-specific Rho GTPase-activating protein(gene name synonym)|uniprotkb:GAB-associated Cdc42/Rac GTPase-activating protein(gene name synonym)|uniprotkb:GC-GAP(gene name synonym)|uniprotkb:Grit(gene name synonym)|uniprotkb:Kiaa0712(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 32(gene name synonym)|uniprotkb:Rho/Cdc42/Rac GTPase-activating protein RICS(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000041444(gene)|ensembl:ENSMUST00000174641(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001650"(fibrillar center)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005938"(cell cortex)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0043197"(dendritic spine)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036028|interpro:IPR036871|interpro:IPR042139|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-9035034|refseq:NP_796353.3|refseq:NP_001182561.1	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:4ZVZeciVms1xmC18riIhaDt9wMY10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9DBT5	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-7780420|ensembl:ENSMUSP00000099697|ensembl:ENSMUSP00000099698|intact:MINT-4616236|uniprotkb:Q91YI2|uniprotkb:A2AE28	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ampd2_mouse(display_long)|uniprotkb:Ampd2(gene name)|psi-mi:Ampd2(display_short)|uniprotkb:AMP deaminase isoform L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000027889(gene)|ensembl:ENSMUST00000102637(transcript)|ensembl:ENSMUST00000102638(transcript)|go:"GO:0003876"(AMP deaminase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006188"(IMP biosynthetic process)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0032264"(IMP salvage)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0052652"(cyclic purine nucleotide metabolic process)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0097009"(energy homeostasis)|interpro:IPR001365(Adenosine/AMP deaminase)|interpro:IPR006329(AMP deaminase)|interpro:IPR006650(Adenosine/AMP deaminase active site)|interpro:IPR029749|interpro:IPR032466|mint:Q9DBT5|reactome:R-MMU-74217|go:"GO:0046039"(GTP metabolic process)|refseq:NP_083055.1|refseq:NP_001276648.1|refseq:NP_001276649.1	-	-	comment:mint|function:AMP deaminase plays a critical role in energy metabolism	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:2i3EpQywgM8qHEU2v1fMCpn/Xes10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P46460	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-398006|uniprotkb:A2A646|uniprotkb:Q8BQ65|uniprotkb:Q8C3R2|uniprotkb:Q8CCT9|uniprotkb:Q8CEF0|uniprotkb:Q923C6|ensembl:ENSMUSP00000099364	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:nsf_mouse(display_long)|uniprotkb:Nsf(gene name)|psi-mi:Nsf(display_short)|uniprotkb:Skd2(gene name synonym)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 2"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_032766.2|ensembl:ENSMUSG00000034187(gene)|ensembl:ENSMUST00000103075(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46460|reactome:R-MMU-204005|reactome:R-MMU-416993|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811438|reactome:R-MMU-6811440	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:mqNfvBVWEdD4caFZug82c88vwE410090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q04690	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-397326|uniprotkb:Q61956|uniprotkb:Q61957|ensembl:ENSMUSP00000071289	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:nf1_mouse(display_long)|uniprotkb:Nf1(gene name)|psi-mi:Nf1(display_short)|uniprotkb:Neurofibromatosis-related protein NF-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_035027.1|refseq:XP_006532504.1|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0008542"(visual learning)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0021510"(spinal cord development)|go:"GO:0021764"(amygdala development)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0021915"(neural tube development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0045685"(regulation of glial cell differentiation)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023152|interpro:IPR036865|interpro:IPR039360|mint:Q04690|go:"GO:0030424"(axon)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035021"(negative regulation of Rac protein signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045545"(syndecan binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|ensembl:ENSMUSG00000020716(gene)|ensembl:ENSMUST00000071325(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001656"(metanephros development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007154"(cell communication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|reactome:R-MMU-5658442	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:aegHzgNy813/APoCjeM166e+MFE10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9EPN1	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-527731|uniprotkb:Q8C931|uniprotkb:Q9EPM9|uniprotkb:Q9EPN0|uniprotkb:Q9WVM9|ensembl:ENSMUSP00000029374	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:nbea_mouse(display_long)|uniprotkb:Lysosomal-trafficking regulator 2(gene name synonym)|uniprotkb:Nbea(gene name)|psi-mi:Nbea(display_short)|uniprotkb:Lyst2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_085098.1|ensembl:ENSMUSG00000027799(gene)|ensembl:ENSMUST00000029374(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0008104"(protein localization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR010508(Protein of unknown function DUF1088)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023362|interpro:IPR031570|interpro:IPR036322|interpro:IPR036372|mint:Q9EPN1|refseq:XP_006501586.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:NWSzMiK/aQ6zHqkCxAoWJSqnrvA10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9JM52	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-645434|uniprotkb:Q5SXG2|uniprotkb:Q921M6|uniprotkb:Q9JM92|ensembl:ENSMUSP00000099619	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:mink1_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase kinase kinase kinase 6(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 6(gene name synonym)|uniprotkb:Misshapen/NIK-related kinase(gene name synonym)|uniprotkb:GCK family kinase MiNK(gene name synonym)|uniprotkb:Mink1(gene name)|psi-mi:Mink1(display_short)|uniprotkb:Map4k6(gene name synonym)|uniprotkb:Mink(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_795712.2|refseq:XP_006533744.1|refseq:NP_057922.2|ensembl:ENSMUSG00000020827(gene)|ensembl:ENSMUST00000102559(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007275"(multicellular organism development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000311"(regulation of AMPA receptor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9JM52|reactome:R-MMU-2559580	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:Kuk8yQcHbIShH9SwsEkvyMTVcMw10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8K310	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-1216295|ensembl:ENSMUSP00000125761|ensembl:ENSMUSP00000158074|ensembl:ENSMUSP00000158537	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:matr3_mouse(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_034901.2|rcsb pdb:1X4F|rcsb pdb:1X4D|ensembl:ENSMUSG00000037236(gene)|ensembl:ENSMUST00000166793(transcript)|ensembl:ENSMUST00000235199(transcript)|ensembl:ENSMUST00000237744(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:Q8K310	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:AwtFbI+oRfha+mn/v3yzG6bNXYg10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P63085	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9WTX8	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-4285225|uniprotkb:Q9WTX9|ensembl:ENSMUSP00000031534	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:md1l1_mouse(display_long)|uniprotkb:Mad1l1(gene name)|psi-mi:Mad1l1(display_short)|uniprotkb:Mad1(gene name synonym)|uniprotkb:Mitotic arrest deficient 1-like protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_034882.2|ensembl:ENSMUSG00000029554(gene)|ensembl:ENSMUST00000031534(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043515"(kinetochore binding)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|mint:Q9WTX8|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|go:"GO:0048538"(thymus development)|refseq:XP_006504714.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:uJ8x1UBlL+30Ss2DFiEhiGLoNfo10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q3UZ39	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2270972|uniprotkb:O70323|uniprotkb:Q3TS94|ensembl:ENSMUSP00000095254	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:lrrf1_mouse(display_long)|uniprotkb:H186 FLAP(gene name synonym)|uniprotkb:FLI-LRR-associated protein 1(gene name synonym)|uniprotkb:Lrrfip1(gene name)|psi-mi:Lrrfip1(display_short)|uniprotkb:Flap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001104781.1|refseq:NP_001104782.1|refseq:NP_032541.1|ensembl:ENSMUSG00000026305(gene)|ensembl:ENSMUST00000097649(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR019139|mint:Q3UZ39	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:LL6ZrfCorNlWgE0W5E5+LVfsqWo10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P14733	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-445247|uniprotkb:Q61791|ensembl:ENSMUSP00000025486	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:lmnb1_mouse(display_long)|uniprotkb:Lmnb1(gene name)|psi-mi:Lmnb1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_034851.2|mint:P14733|reactome:R-MMU-9035034|reactome:R-MMU-2559584|reactome:R-MMU-352238|reactome:R-MMU-4419969|reactome:R-MMU-9013405|ensembl:ENSMUSG00000024590(gene)|ensembl:ENSMUST00000025486(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:1904609"(cellular response to monosodium L-glutamate)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|go:"GO:0003690"(double-stranded DNA binding)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:/Mo4KS6v6KhDRlYgD5CVVVtWVD810090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9Z2I0	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-776352|uniprotkb:Q5PQC5|uniprotkb:Q7TMK8|uniprotkb:Q80ZX6|uniprotkb:Q8CGJ3|uniprotkb:Q8K5E5|ensembl:ENSMUSP00000005431	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:letm1_mouse(display_long)|uniprotkb:Leucine zipper-EF-hand-containing transmembrane protein 1(gene name synonym)|uniprotkb:Letm1(gene name)|psi-mi:Letm1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_062668.1|ensembl:ENSMUSG00000005299(gene)|ensembl:ENSMUST00000005431(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006875"(cellular metal ion homeostasis)|go:"GO:0015369"("calcium:proton antiporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0034214"(protein hexamerization)|go:"GO:0042407"(cristae formation)|go:"GO:0043022"(ribosome binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0099093"(calcium export from the mitochondrion)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|interpro:IPR011685(LETM1-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR033122|interpro:IPR044202|mint:Q9Z2I0|reactome:R-MMU-9013408	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:Vuq2yh9PzGcTantvKXibFL6bjV010090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q3UVC0	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732139	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ksr2_mouse(display_long)|uniprotkb:Ksr2(gene name)|psi-mi:Ksr2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	reactome:R-MMU-5674135|go:"GO:0004672"(protein kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR013761(Sterile alpha motif-type)|refseq:NP_001299843.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR025561|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:PS2nz+rHvedtCjCXqlqfbcn8G/k10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P28740	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-776122|uniprotkb:O54744|uniprotkb:Q91W03|ensembl:ENSMUSP00000022204	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kif2a_mouse(display_long)|uniprotkb:Kif2a(gene name)|psi-mi:Kif2a(display_short)|uniprotkb:Kif2(gene name synonym)|uniprotkb:Kns2(gene name synonym)|uniprotkb:Kinesin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001139251.1|refseq:XP_006517602.1|ensembl:ENSMUSG00000021693(gene)|ensembl:ENSMUST00000022204(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0051301"(cell division)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097228"(sperm principal piece)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P28740|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-6811434|reactome:R-MMU-68877|reactome:R-MMU-9648025|reactome:R-MMU-983189	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:xPWg0rzeKQooA3AM2Ics+e/QnRM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:E9Q4K7	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-9085496|ensembl:ENSMUSP00000098041	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:e9q4k7_mouse(display_long)|uniprotkb:Kif13b(gene name)|psi-mi:Kif13b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001074646.1|dip:DIP-61928N|ensembl:ENSMUSG00000060012(gene)|ensembl:ENSMUST00000100473(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005902"(microvillus)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0033270"(paranode region of axon)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:1990939"|interpro:IPR000253(Forkhead-associated)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019821|interpro:IPR022140|interpro:IPR022164|interpro:IPR027417|interpro:IPR032405|interpro:IPR036859|interpro:IPR036961|rcsb pdb:5B64	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:FPzCTsgR0iwDPBqRiio7hJ2k6/s10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:A2CG49	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-770321|uniprotkb:A2CG50|uniprotkb:A2CG51|uniprotkb:A2CG52|uniprotkb:A2CG53|uniprotkb:Q3TYL1|uniprotkb:Q3UTA5|uniprotkb:Q8BTT9|uniprotkb:Q8C4Q2|uniprotkb:Q9CVA9|uniprotkb:Q3TXY8|uniprotkb:B2RXR5|uniprotkb:D3Z559|ensembl:ENSMUSP00000076088	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kalrn_mouse(display_long)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001157740.1|refseq:XP_006522445.1|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018159|interpro:IPR028570|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSMUSG00000061751(gene)|ensembl:ENSMUST00000076810(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0035176"(social behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042711"(maternal behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046959"(habituation)|mint:A2CG49|rcsb pdb:1WFW|reactome:R-MMU-193648|reactome:R-MMU-3928662|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5687128|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013408|interpro:IPR036865	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:pDqdA2QNbqgLE3eYQXVVW2cxIyo10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q5DTN8	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732117|ensembl:ENSMUSP00000130207|uniprotkb:Q0VDR4|uniprotkb:Q0VDR5|uniprotkb:Q9CU41	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:jkip3_mouse(display_long)|uniprotkb:Neuroendocrine long coiled-coil protein 2(gene name synonym)|uniprotkb:Jakmip3(gene name)|psi-mi:Jakmip3(display_short)|uniprotkb:Kiaa4091(gene name synonym)|uniprotkb:Necc2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000056856(gene)|ensembl:ENSMUST00000166163(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008017"(microtubule binding)|go:"GO:0019900"(kinase binding)|interpro:IPR024836|interpro:IPR031994|refseq:NP_082984.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:cA/7CpC943hQZnQIMCD2iA2MamY10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:D3YXK0	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732102|ensembl:ENSMUSP00000080881	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:d3yxk0_mouse(display_long)|uniprotkb:Jakmip2(gene name)|psi-mi:Jakmip2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000024502(gene)|ensembl:ENSMUST00000082254(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008017"(microtubule binding)|go:"GO:0019900"(kinase binding)|interpro:IPR024836|interpro:IPR031994|refseq:NP_001157109.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:rygZ3X2EiNdZN7VDdLAhhZrj+mw10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8BVL9	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732076|ensembl:ENSMUSP00000038504|uniprotkb:B2RS01	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:jkip1_mouse(display_long)|uniprotkb:GABA-B receptor-binding protein(gene name synonym)|uniprotkb:Multiple alpha-helices and RNA-linker protein 1(gene name synonym)|uniprotkb:Jakmip1(gene name)|psi-mi:Jakmip1(display_short)|uniprotkb:Gababrbp(gene name synonym)|uniprotkb:Marlin1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000063646(gene)|ensembl:ENSMUST00000043794(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019894"(kinesin binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0021756"(striatum development)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0050890"(cognition)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR024836|interpro:IPR031994|refseq:NP_848481.2|refseq:XP_017176628.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:mwxEKe8Wgm7UKTRWegODX1fjUxU10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8R0S2	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-772277|uniprotkb:Q3TZC3|uniprotkb:Q5DU15|ensembl:ENSMUSP00000098712	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:iqec1_mouse(display_long)|uniprotkb:Iqsec1(gene name)|psi-mi:Iqsec1(display_short)|uniprotkb:Kiaa0763(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001127855.1|ensembl:ENSMUSG00000034312(gene)|ensembl:ENSMUST00000101153(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR030737|interpro:IPR033742|interpro:IPR035999	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:BZg7CaLndE4ak8KXs34YFf9iBRQ10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8BUK6	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-1777179|uniprotkb:Q8BV48|uniprotkb:Q8BW57|uniprotkb:Q8BY41|uniprotkb:Q540A0|ensembl:ENSMUSP00000046788	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:hook3_mouse(display_long)|uniprotkb:Hook3(gene name)|psi-mi:Hook3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_997542.1|ensembl:ENSMUSG00000037234(gene)|ensembl:ENSMUST00000037182(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0030897"(HOPS complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|mint:Q8BUK6	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:PUiCL1lU5asAM+rngKPeVDsgomE10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9Z2Y3	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6NZM9	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8C419	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9CW79	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2270312|uniprotkb:Q80YB0|uniprotkb:A3KGQ9|ensembl:ENSMUSP00000037735|ensembl:ENSMUSP00000139001	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:goga1_mouse(display_long)|uniprotkb:Golga1(gene name)|psi-mi:Golga1(display_short)|uniprotkb:Golgin-97(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_084069.1|refseq:NP_001277578.1|ensembl:ENSMUSG00000026754(gene)|ensembl:ENSMUST00000039165(transcript)|ensembl:ENSMUST00000184996(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0016020"(membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000237(GRIP)|reactome:R-MMU-6811440	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:Ulkj85aZnJxe6cy2poWp4ud9l/g10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q68FF6	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-645933|ensembl:ENSMUSP00000037210	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8VDC1	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16727814|ensembl:ENSMUSP00000081764|ensembl:ENSMUSP00000133222|uniprotkb:Q3V385|uniprotkb:Q7TMT0|uniprotkb:Q8BJN2	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:fyco1_mouse(display_long)|uniprotkb:Fyco1(gene name)|psi-mi:Fyco1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000025241(gene)|ensembl:ENSMUST00000084715(transcript)|ensembl:ENSMUST00000167595(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0072383"(plus-end-directed vesicle transport along microtubule)|go:"GO:1901098"(positive regulation of autophagosome maturation)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR004012(RUN)|interpro:IPR009038(GOLD)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR036598|interpro:IPR037213|interpro:IPR042654|rcsb pdb:5WRD|refseq:NP_001103723.2|refseq:NP_683727.3|refseq:XP_017168648.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:UQrU+0SySU+oBd+pE2OneGw0oog10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:E9Q8I9	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732044|ensembl:ENSMUSP00000084454|uniprotkb:Q4VA57|uniprotkb:Q5DTL4|uniprotkb:Q8BIW6|uniprotkb:Q8BUA0|uniprotkb:Q8CG91	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:fry_mouse(display_long)|uniprotkb:Fry(gene name)|psi-mi:Fry(display_short)|uniprotkb:Kiaa4143(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000056602(gene)|ensembl:ENSMUST00000087204(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005938"(cell cortex)|go:"GO:0030427"(site of polarized growth)|go:"GO:0031175"(neuron projection development)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025481|interpro:IPR025614|interpro:IPR029473|interpro:IPR039867|mint:E9Q8I9|refseq:NP_766475.2|refseq:XP_006504993.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:fvduzhqkwcM9qmnWvPWAA1W8HqI10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8C3F2	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16728136|ensembl:ENSMUSP00000073082|uniprotkb:Q3U0F6	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:f120c_mouse(display_long)|uniprotkb:Protein FAM120C(gene name synonym)|uniprotkb:Fam120c(gene name)|psi-mi:Fam120c(display_short)|uniprotkb:ORF34(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000025262(gene)|go:"GO:0005634"(nucleus)|interpro:IPR026784|interpro:IPR026785|interpro:IPR029060|mint:Q8C3F2|ensembl:ENSMUST00000073364(transcript)|refseq:NP_932773.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:7t8xHEO+ShbLsdqIbH6xQm7UcPw10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P26040	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-645505|uniprotkb:Q80ZT8|uniprotkb:Q9DCI1|ensembl:ENSMUSP00000063734	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ezri_mouse(display_long)|uniprotkb:Vil2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)|uniprotkb:Ezr(gene name)|psi-mi:Ezr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_033536.2|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|interpro:IPR008954(Moesin)|mint:P26040|reactome:R-MMU-373752|reactome:R-MMU-437239|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|ensembl:ENSMUSG00000052397(gene)|ensembl:ENSMUST00000064234(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:PspmkV3JA32h1VGLkUgha3a59AA10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6PH08	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16726089|ensembl:ENSMUSP00000147886|uniprotkb:Q80U20|uniprotkb:Q8CCP1	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:erc2_mouse(display_long)|uniprotkb:CAZ-associated structural protein 1(gene name synonym)|uniprotkb:Erc2(gene name)|psi-mi:Erc2(display_short)|uniprotkb:Cast1(gene name synonym)|uniprotkb:D14Ertd171e(gene name synonym)|uniprotkb:Kiaa0378(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000040640(gene)|ensembl:ENSMUST00000211145(transcript)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048790"(maintenance of presynaptic active zone structure)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|interpro:IPR019323|interpro:IPR030625|refseq:NP_808482.2|refseq:XP_006519013.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:bmubXKmJ7vf/Hxo37UGDaxgYamM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q03173	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-6083294|uniprotkb:P70430|uniprotkb:P70431|uniprotkb:P70432|uniprotkb:P70433|uniprotkb:Q5D053	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:enah_mouse(display_long)|uniprotkb:Enah(gene name)|psi-mi:Enah(display_short)|uniprotkb:Mena(gene name synonym)|uniprotkb:Ndpp1(gene name synonym)|uniprotkb:NPC-derived proline-rich protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	mint:Q03173|refseq:NP_001076590.1|dip:DIP-29359N|go:"GO:0001725"(stress fiber)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0045202"(synapse)|go:"GO:0050699"(WW domain binding)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR038023|rcsb pdb:1EVH|rcsb pdb:4CC3|reactome:R-MMU-376176	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:MLNC5NL3QIW9Y/aUkc9dTNNAedM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P70372	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-6877056|ensembl:ENSMUSP00000096549|ensembl:ENSMUSP00000146866|uniprotkb:Q60745|uniprotkb:Q78QY3	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:elav1_mouse(display_long)|uniprotkb:Elavl1(gene name)|psi-mi:Elavl1(display_short)|uniprotkb:Elra(gene name synonym)|uniprotkb:Hua(gene name synonym)|uniprotkb:Elav-like generic protein(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym)|uniprotkb:MelG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000040028(gene)|ensembl:ENSMUST00000098950(transcript)|ensembl:ENSMUST00000209010(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:P70372|reactome:R-MMU-450520|reactome:R-MMU-72163|go:"GO:0019901"(protein kinase binding)|refseq:XP_006508761.1|refseq:NP_034615.2|dip:DIP-46480N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:iKHrpZqi5b7EFLkfVJSRTpi9sj010090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:O08553	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-446064|uniprotkb:Q6P5D0|ensembl:ENSMUSP00000022629	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:dpyl2_mouse(display_long)|uniprotkb:Unc-33-like phosphoprotein 2(gene name synonym)|uniprotkb:Dpysl2(gene name)|psi-mi:Dpysl2(display_short)|uniprotkb:Crmp2(gene name synonym)|uniprotkb:Ulip2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_034085.2|ensembl:ENSMUSG00000022048(gene)|ensembl:ENSMUST00000022629(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043209"(myelin sheath)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098793"(presynapse)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030615|interpro:IPR032466|mint:O08553|rcsb pdb:5UQC|reactome:R-MMU-399956|reactome:R-MMU-437239	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:97yc8TNEPMcGtGNRLvl+KV+DYr010090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:D4AFX7	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-10729612|ensembl:ENSMUSP00000139804	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:d4afx7_mouse(display_long)|uniprotkb:Dnajc13(gene name)|psi-mi:Dnajc13(display_short)|uniprotkb:RME-8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:XP_006511771.1|ensembl:ENSMUSG00000032560(gene)|ensembl:ENSMUST00000186788(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071203"(WASH complex)|go:"GO:1902954"(regulation of early endosome to recycling endosome transport)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025640|interpro:IPR035445|interpro:IPR036869|reactome:R-MMU-6798695|go:"GO:0010008"(endosome membrane)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:x7JrboPFDyZPFyFIY1gJoKV1zgE10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q3UH60	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16724475|ensembl:ENSMUSP00000097777|uniprotkb:Q8C1W5|uniprotkb:Q8CDG9|uniprotkb:Q8CHA2	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:dip2b_mouse(display_long)|uniprotkb:Dip2b(gene name)|psi-mi:Dip2b(display_short)|uniprotkb:Kiaa1463(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000023026(gene)|ensembl:ENSMUST00000100203(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR010506(DMAP1-binding)|interpro:IPR037337|interpro:IPR042099|mint:Q3UH60|refseq:NP_001152833.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:fgjJT8HpeVRm1osKj8p2Dx7WxU810090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q3UHC7	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-6306507|ensembl:ENSMUSP00000088532|uniprotkb:A2AUW9|uniprotkb:A2AUX2|uniprotkb:B7ZD28|uniprotkb:Q3TPD5|uniprotkb:Q3UH44|uniprotkb:Q6JTV1|uniprotkb:Q80T97|uniprotkb:A5X2X2|uniprotkb:Q6Y636	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:dab2p_mouse(display_long)|uniprotkb:ASK-interacting protein 1(gene name synonym)|uniprotkb:DOC-2/DAB-2 interactive protein(gene name synonym)|uniprotkb:Dab2ip(gene name)|psi-mi:Dab2ip(display_short)|uniprotkb:Kiaa1743(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000026883(gene)|ensembl:ENSMUST00000091010(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007049"(cell cycle)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021814"(cell motility involved in cerebral cortex radial glia guided migration)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035148"(tube formation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043553"(negative regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044301"(climbing fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1903363"(negative regulation of cellular protein catabolic process)|go:"GO:1990032"(parallel fiber)|go:"GO:1990597"(AIP1-IRE1 complex)|go:"GO:2001224"(positive regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR030403|interpro:IPR035892|interpro:IPR039360|reactome:R-MMU-5658442|interpro:IPR001849(Pleckstrin-like)|refseq:NP_001277568.1|refseq:NP_001277569.1|refseq:NP_001277570.1|refseq:NP_001001602.2|refseq:NP_001107596.1|refseq:NP_001107597.1|refseq:XP_006498370.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:2TdjnHyR0jQG+iT5S5+JaK8hhfY10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P53564	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-642309|uniprotkb:O08994|uniprotkb:P70301|uniprotkb:Q571L6|uniprotkb:Q91ZD2	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:cux1_mouse(display_long)|uniprotkb:CCAAT displacement protein(gene name synonym)|uniprotkb:Homeobox protein cux-1(gene name synonym)|uniprotkb:Kiaa4047(gene name synonym)|uniprotkb:Cux1(gene name)|psi-mi:Cux1(display_short)|uniprotkb:Cux(gene name synonym)|uniprotkb:Cutl1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	interpro:IPR003350(Homeodomain protein CUT)|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|mint:P53564|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030324"(lung development)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0043005"(neuron projection)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|refseq:NP_001278162.1|refseq:NP_001278163.1|refseq:NP_034116.3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:XozohEVVgGk0JJ5Qaw2AmPO+dHI10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q60598	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q02248	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P16330	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-772515|uniprotkb:Q61424|uniprotkb:Q8C7C9|uniprotkb:Q91V42|uniprotkb:Q923F3|ensembl:ENSMUSP00000099409	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:cn37_mouse(display_long)|uniprotkb:Cnp(gene name)|psi-mi:Cnp(display_short)|uniprotkb:Cnp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001139790.1|refseq:NP_034053.2|refseq:XP_017169734.1|ensembl:ENSMUSG00000006782(gene)|ensembl:ENSMUST00000103120(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003723"(RNA binding)|go:"GO:0004113"(2',3'-cyclic-nucleotide 3'-phosphodiesterase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009214"(cyclic nucleotide catabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030551"(cyclic nucleotide binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031143"(pseudopodium)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|interpro:IPR008431(Cyclic nucleotide phosphodiesterase)|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|interpro:IPR027417|mint:P16330|rcsb pdb:2XMI|rcsb pdb:2Y1P|rcsb pdb:2Y3X|rcsb pdb:2YDB|rcsb pdb:2YDC|rcsb pdb:2YDD|rcsb pdb:2YOZ|rcsb pdb:2YP0|rcsb pdb:2YPC|rcsb pdb:2YPE|rcsb pdb:2YPH|rcsb pdb:2YQ9|rcsb pdb:3ZBR|rcsb pdb:3ZBS|rcsb pdb:3ZBZ|rcsb pdb:4WBI|rcsb pdb:4WBL|rcsb pdb:4WC9|rcsb pdb:4WCA|rcsb pdb:4WCB|rcsb pdb:4WCC|rcsb pdb:4WDA|rcsb pdb:4WDB|rcsb pdb:4WDD|rcsb pdb:4WDE|rcsb pdb:4WDF|rcsb pdb:4WDG|rcsb pdb:4WDH|rcsb pdb:4WEX|rcsb pdb:4WFR|rcsb pdb:5AE0	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:z0XniuUAwQzaZTvQmEmctKYNw9810090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8BMA3	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16724595|ensembl:ENSMUSP00000015346|uniprotkb:Q3UDS2|uniprotkb:Q8K2K0	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:cnkr3_mouse(display_long)|uniprotkb:CNK homolog protein 3(gene name synonym)|uniprotkb:CNKSR family member 3(gene name synonym)|uniprotkb:Maguin-like protein(gene name synonym)|uniprotkb:Cnksr3(gene name)|psi-mi:Cnksr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000015202(gene)|ensembl:ENSMUST00000015346(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|refseq:NP_766134.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:VU017cJ6L0oSQSKNSH5wShA80Lg10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q06890	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-774758|ensembl:ENSMUSP00000022616	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:clus_mouse(display_long)|uniprotkb:Sulfated glycoprotein 2(gene name synonym)|uniprotkb:Clustrin(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:Clu(gene name)|psi-mi:Clu(display_short)|uniprotkb:Apoj(gene name synonym)|uniprotkb:Msgp-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_038520.2|refseq:XP_006518567.1|ensembl:ENSMUSG00000022037(gene)|ensembl:ENSMUST00000022616(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002434"(immune complex clearance)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016235"(aggresome)|go:"GO:0017038"(protein import)|go:"GO:0030426"(growth cone)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0071944"(cell periphery)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0099020"(perinuclear endoplasmic reticulum lumen)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902847"(regulation of neuronal signal transduction)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1905892"(negative regulation of cellular response to thapsigargin)|go:"GO:1905895"(negative regulation of cellular response to tunicamycin)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000753(Clusterin-like)|interpro:IPR016014(Clusterin, N-terminal)|interpro:IPR016015(Clusterin, C-terminal)|interpro:IPR016016(Clusterin)|interpro:IPR033986|mint:Q06890|reactome:R-MMU-114608|reactome:R-MMU-166665|reactome:R-MMU-6803157|reactome:R-MMU-977606|go:"GO:0042583"(chromaffin granule)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:wP6AESslzICF3ojv9a+vJUn61VA10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9Z0H8	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-775282|uniprotkb:Q7TSI9|uniprotkb:Q8CHU1|uniprotkb:Q9EP81|ensembl:ENSMUSP00000098212	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:clip2_mouse(display_long)|uniprotkb:Cytoplasmic linker protein 2(gene name synonym)|uniprotkb:Cytoplasmic linker protein 115(gene name synonym)|uniprotkb:Clip2(gene name)|psi-mi:Clip2(display_short)|uniprotkb:Kiaa0291(gene name synonym)|uniprotkb:Cyln2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001034251.1|refseq:NP_034120.2|ensembl:ENSMUSG00000063146(gene)|ensembl:ENSMUST00000100647(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042599"(lamellar body)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:1901588"(dendritic microtubule)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR028394|interpro:IPR036859|mint:Q9Z0H8	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:XOvAwO1BpspbwnEPfothhJzQ7ns10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q922J3	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-776187|uniprotkb:Q571L7|ensembl:ENSMUSP00000107192	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:clip1_mouse(display_long)|uniprotkb:Restin(gene name synonym)|uniprotkb:Clip1(gene name)|psi-mi:Clip1(display_short)|uniprotkb:Kiaa4046(gene name synonym)|uniprotkb:Rsn(gene name synonym)|uniprotkb:Cytoplasmic linker protein 170(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_062739.2|refseq:NP_001278158.1|ensembl:ENSMUSG00000049550(gene)|ensembl:ENSMUST00000111566(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001726"(ruffle)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042802"(identical protein binding)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0051010"(microtubule plus-end binding)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR032108|interpro:IPR036859|mint:Q922J3|rcsb pdb:2CP7|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:VamQo+KVLXsd4aHycgXJlQF2Bw010090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8BRT1	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-776004|uniprotkb:Q8CHE3|uniprotkb:Q99JI3|uniprotkb:Q9DB80	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:clap2_mouse(display_long)|uniprotkb:Cytoplasmic linker-associated protein 2(gene name synonym)|uniprotkb:Clasp2(gene name)|psi-mi:Clasp2(display_short)|uniprotkb:Kiaa0627(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001273528.1|refseq:NP_001273529.1|refseq:NP_001273530.1|refseq:NP_001273531.1|refseq:NP_001273532.1|mint:Q8BRT1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024395|interpro:IPR034085|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006903"(vesicle targeting)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045180"(basal cortex)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903754"(cortical microtubule plus-end)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|rcsb pdb:3WOZ|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:ACnxijHc8A5KYqR4CDmSg2U5OYk10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q80TV8	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-908322|uniprotkb:Q505G6|uniprotkb:Q6DI75|uniprotkb:Q6PG14|uniprotkb:Q8BNS4|uniprotkb:Q99JH5|uniprotkb:Q99JI2|uniprotkb:Q9CVU1	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:clap1_mouse(display_long)|uniprotkb:Clasp1(gene name)|psi-mi:Clasp1(display_short)|uniprotkb:Cytoplasmic linker-associated protein 1(gene name synonym)|uniprotkb:Kiaa0622(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001280229.1|refseq:NP_001280230.1|refseq:NP_083985.2|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024395|interpro:IPR021133|interpro:IPR028399|interpro:IPR034085|mint:Q80TV8|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0006903"(vesicle targeting)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0030981"(cortical microtubule cytoskeleton)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031592"(centrosomal corona)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0043515"(kinetochore binding)|go:"GO:0045180"(basal cortex)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-2500257	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:HwJCOu/w9CSWzqLB7WEjrC4a3bg10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P49025	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-397301|intact:EBI-487846|uniprotkb:O88528|uniprotkb:O88937|uniprotkb:O88938|uniprotkb:Q3UM99|uniprotkb:Q8CIJ1	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ctro_mouse(display_long)|uniprotkb:Cit(gene name)|psi-mi:Cit(display_short)|uniprotkb:Rho-interacting, serine/threonine-protein kinase 21(gene name synonym)|uniprotkb:Crik(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR017405(Citron Rho-interacting kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|refseq:XP_006530214.1|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001726"(ruffle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR037708|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005856"(cytoskeleton)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048699"(generation of neurons)|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-5625900	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:8kykadVIiyk12GjGCZNn0bQ13C010090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q80U49	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16728053|ensembl:ENSMUSP00000098580|ensembl:ENSMUSP00000137331|ensembl:ENSMUSP00000152451|uniprotkb:Q3UH33|uniprotkb:Q3UHG1|uniprotkb:Q80UM2	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:c170b_mouse(display_long)|uniprotkb:Centrosomal protein 170B(gene name synonym)|uniprotkb:Cep170b(gene name)|psi-mi:Cep170b(display_short)|uniprotkb:Kiaa0284(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000072825(gene)|ensembl:ENSMUST00000101018(transcript)|ensembl:ENSMUST00000179041(transcript)|ensembl:ENSMUST00000222711(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029300|refseq:NP_001019773.2|refseq:XP_006515829.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:vmI/x564L8rTcob6vkmQLu2+JCQ10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6A065	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2554140|uniprotkb:Q7TQD9|uniprotkb:Q8BJW2|uniprotkb:Q9D3Z0|ensembl:ENSMUSP00000141793	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ce170_mouse(display_long)|uniprotkb:Kiaa0470(gene name synonym)|uniprotkb:Cep170(gene name)|psi-mi:Cep170(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000057335(gene)|ensembl:ENSMUST00000194727(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q6A065|refseq:XP_006497000.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:gawEp+b6DVpUroRU0JHmHzo7qPg10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q7TSH3	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-645074|ensembl:ENSMUSP00000071216|ensembl:ENSMUSP00000126629	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:zn516_mouse(display_long)|uniprotkb:Znf516(gene name)|psi-mi:Znf516(display_short)|uniprotkb:Kiaa0222(gene name synonym)|uniprotkb:Zfp516(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001170935.1|refseq:NP_898854.1|refseq:XP_006526561.1|refseq:XP_006526562.1|refseq:XP_006526563.1|refseq:XP_006526564.1|refseq:XP_006526565.1|refseq:XP_006526566.1|refseq:XP_011245387.1|ensembl:ENSMUSG00000058881(gene)|ensembl:ENSMUST00000071233(transcript)|ensembl:ENSMUST00000171238(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0009409"(response to cold)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q7TSH3	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:ZHf1LTueAKPZvNSSHt1obLOPQ8010090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9Z0G7	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732462|ensembl:ENSMUSP00000057466	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:zbt22_mouse(display_long)|uniprotkb:Protein BING1(gene name synonym)|uniprotkb:Zinc finger protein 297(gene name synonym)|uniprotkb:Zbtb22(gene name)|psi-mi:Zbtb22(display_short)|uniprotkb:Bing1(gene name synonym)|uniprotkb:Zfp297(gene name synonym)|uniprotkb:Znf297(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000051390(gene)|ensembl:ENSMUST00000053429(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR029833|interpro:IPR036236|interpro:IPR000210(BTB/POZ-like)|refseq:NP_065650.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:ZUg4jLqKYHyBigBV0SXAd5XM6YY10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P23475	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-822760|uniprotkb:Q3UJL8|uniprotkb:Q6GTV8|uniprotkb:Q8QZX7|uniprotkb:O88212|uniprotkb:Q62027|uniprotkb:Q62382|uniprotkb:Q62453	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:xrcc6_mouse(display_long)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Ku autoantigen protein p70 homolog(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:Xrcc6(gene name)|psi-mi:Xrcc6(display_short)|uniprotkb:G22p1(gene name synonym)|uniprotkb:Ku70(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	mint:P23475|refseq:NP_034377.2|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|refseq:XP_006520505.1|refseq:XP_006520506.1|refseq:XP_011243758.1|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|go:"GO:0000723"(telomere maintenance)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|reactome:R-MMU-5693571|reactome:R-MMU-6798695	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:/A6ygYkLE2FpziX/3fMu5IvG0iI10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P20152	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-299269|ensembl:ENSMUSP00000028062|uniprotkb:O08704|uniprotkb:Q8CCH1	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:vime_mouse(display_long)|uniprotkb:Vim(gene name)|psi-mi:Vim(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000026728(gene)|ensembl:ENSMUST00000028062(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1900147"(regulation of Schwann cell migration)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031252"(cell leading edge)|interpro:IPR027699|interpro:IPR039008|mint:P20152|reactome:R-MMU-264870|reactome:R-MMU-390522|reactome:R-MMU-9013422|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|reactome:R-MMU-9646399|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044297"(cell body)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045103"(intermediate filament-based process)|refseq:NP_035831.2|dip:DIP-188N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid://GDvGAXOR4hUXNtVpnZefex5v410090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q80X50	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-11664310|uniprotkb:Q8BIT6|uniprotkb:Q8BIW4|uniprotkb:Q8BJ01|uniprotkb:Q8CIG7|uniprotkb:Q8K102|uniprotkb:Q9CRT6|ensembl:ENSMUSP00000143459	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ubp2l_mouse(display_long)|uniprotkb:Ubap2l(gene name)|psi-mi:Ubap2l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001159455.1|refseq:NP_001159456.1|refseq:NP_001159457.1|refseq:NP_001159458.1|refseq:NP_082751.1|refseq:XP_006502235.1|ensembl:ENSMUSG00000042520(gene)|ensembl:ENSMUST00000196843(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q80X50|rcsb pdb:1WJ7	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:ucHEy1MXF7PTEdwLChr6zAOqtcM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q02053	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2310520|uniprotkb:A6H6S6|uniprotkb:P31253|uniprotkb:Q542H8|ensembl:ENSMUSP00000001989|ensembl:ENSMUSP00000086626	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:uba1_mouse(display_long)|uniprotkb:Uba1(gene name)|psi-mi:Uba1(display_short)|uniprotkb:Sbx(gene name synonym)|uniprotkb:Ube1(gene name synonym)|uniprotkb:Ube1ax(gene name synonym)|uniprotkb:Ube1x(gene name synonym)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Ubiquitin-like modifier-activating enzyme 1 X(gene name synonym)|uniprotkb:Ubiquitin-activating enzyme E1 X(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001129557.1|refseq:NP_001263245.1|refseq:NP_001263246.1|refseq:NP_033483.2|ensembl:ENSMUSG00000001924(gene)|ensembl:ENSMUST00000001989(transcript)|ensembl:ENSMUST00000089217(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030057"(desmosome)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0032446"(protein modification by small protein conjugation)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:Q02053|rcsb pdb:1Z7L|rcsb pdb:2LZJ|rcsb pdb:2V31|reactome:R-MMU-8866652|reactome:R-MMU-983168|interpro:IPR019572	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:358Lm1CC2dWXeDL+IXAM2KaOlqM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8CG79	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-645416|uniprotkb:Q3UYM7|uniprotkb:Q8K2L5	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:aspp2_mouse(display_long)|uniprotkb:Tumor suppressor p53-binding protein 2(gene name synonym)|uniprotkb:Tp53bp2(gene name)|psi-mi:Tp53bp2(display_short)|uniprotkb:Aspp2(gene name synonym)|uniprotkb:Trp53bp2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_775554.2|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR001452(Src homology-3)|interpro:IPR029071|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR036028|interpro:IPR036770|reactome:R-MMU-6804759	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:Ygl3S/FVLP/3gD2F0o5t016B2Bk10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P70399	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-769130|uniprotkb:Q68FD0|uniprotkb:Q8CI97|uniprotkb:Q91YC9|intact:EBI-11051502|intact:EBI-11516626|uniprotkb:A2AU89|uniprotkb:A2AU91|ensembl:ENSMUSP00000106278	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:tp53b_mouse(display_long)|uniprotkb:Tp53bp1(gene name)|psi-mi:Tp53bp1(display_short)|uniprotkb:Trp53bp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001277759.1|refseq:NP_038763.3|dip:DIP-31595N|refseq:XP_011237883.1|ensembl:ENSMUSG00000043909(gene)|ensembl:ENSMUST00000110648(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:P70399|rcsb pdb:1SSF|reactome:R-MMU-3232118|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:z5tOHbR6ApNZRL9aptim/xRaVo010090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6ZWQ0	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-11517168|uniprotkb:Q640M5|ensembl:ENSMUSP00000047697	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:syne2_mouse(display_long)|uniprotkb:Nuclear envelope spectrin repeat protein 2(gene name synonym)|uniprotkb:Nucleus and actin connecting element protein(gene name synonym)|uniprotkb:Synaptic nuclear envelope protein 2(gene name synonym)|uniprotkb:KASH domain-containing protein 2(gene name synonym)|uniprotkb:Syne2(gene name)|psi-mi:Syne2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	dip:DIP-61049N|refseq:NP_001005510.2|ensembl:ENSMUSG00000063450(gene)|ensembl:ENSMUST00000044217(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0005739"(mitochondrion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031981"(nuclear lumen)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0007097"(nuclear migration)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051642"(centrosome localization)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR012315(Klarsicht/ANC-1/syne-1 homology)|interpro:IPR018159|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|interpro:IPR030266|interpro:IPR036872|mint:Q6ZWQ0	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:dByvgsaISSaQdpGCQahK7a5mG2w10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q499E5	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732435|ensembl:ENSMUSP00000078190|uniprotkb:B2RR59|uniprotkb:Q3TRF0|uniprotkb:Q497F9|uniprotkb:Q6ZPS3|uniprotkb:Q8CDI1	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:stox2_mouse(display_long)|uniprotkb:Stox2(gene name)|psi-mi:Stox2(display_short)|uniprotkb:Kiaa1392(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000038143(gene)|ensembl:ENSMUST00000079195(transcript)|go:"GO:0001893"(maternal placenta development)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009617"(response to bacterium)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|interpro:IPR019391|interpro:IPR040126|refseq:NP_001107783.1|refseq:NP_001273305.1|refseq:NP_780371.3|refseq:XP_011240539.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:Hyb1pHTXulFJPvZ592wBOvPTCQ810090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:E1U8D0	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16728709	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:soga1_mouse(display_long)|uniprotkb:SOGA family member 1(gene name synonym)|uniprotkb:Suppressor of glucose by autophagy(gene name synonym)|uniprotkb:Suppressor of glucose, autophagy-associated protein 1(gene name synonym)|uniprotkb:Soga1(gene name)|psi-mi:Soga1(display_short)|uniprotkb:Soga(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	go:"GO:0005615"(extracellular space)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0045721"(negative regulation of gluconeogenesis)|interpro:IPR027882|interpro:IPR027881	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:Kk7DCpjGgjPDQ/NrzlscsMuBDGg10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q80U72	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-1766028|uniprotkb:Q6P5H7|uniprotkb:Q7TPH8|uniprotkb:Q80VB1|uniprotkb:Q8CI48|uniprotkb:Q8VII1|uniprotkb:Q922S3|ensembl:ENSMUSP00000068056	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:scrib_mouse(display_long)|uniprotkb:Scrib(gene name)|psi-mi:Scrib(display_short)|uniprotkb:Kiaa0147(gene name synonym)|uniprotkb:Lap4(gene name synonym)|uniprotkb:Scrib1(gene name synonym)|uniprotkb:Protein LAP4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_598850.1|refseq:XP_017171844.1|refseq:NP_001297471.1|refseq:NP_001297472.1|dip:DIP-40660N|ensembl:ENSMUSG00000022568(gene)|ensembl:ENSMUST00000063747(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001843"(neural tube closure)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0008104"(protein localization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016477"(cell migration)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036034|mint:Q80U72|reactome:R-MMU-9013148|reactome:R-MMU-9013406|reactome:R-MMU-9696264|reactome:R-MMU-9696270	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:WF4b5QAjIGIgq6tnexNZtDhI7gk10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P70335	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-989293|uniprotkb:Q8C3G4|uniprotkb:Q8C7H0|ensembl:ENSMUSP00000069549	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:rock1_mouse(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 1(gene name synonym)|uniprotkb:p160 ROCK-1(gene name synonym)|uniprotkb:Rock1(gene name)|psi-mi:Rock1(display_short)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	go:"GO:0007159"(leukocyte cell-cell adhesion)|ensembl:ENSMUSG00000024290(gene)|ensembl:ENSMUST00000067947(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003383"(apical constriction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0071559"(response to transforming growth factor beta)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR037310|mint:P70335|reactome:R-MMU-111465|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5627117|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013407|reactome:R-MMU-9013422|reactome:R-MMU-9696264|interpro:IPR011072(HR1 rho-binding repeat)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032059"(bleb)|go:"GO:0032060"(bleb assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051451"(myoblast migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|refseq:NP_033097.1|refseq:XP_006525788.1|dip:DIP-35521N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:BIAb7c+Ar8WI6cES/igerUjk1zc10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9WVM1	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2552104|ensembl:ENSMUSP00000023756|ensembl:ENSMUSP00000126417|uniprotkb:Q3TI41|uniprotkb:Q3TM81|uniprotkb:Q3THR5	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:rgap1_mouse(display_long)|uniprotkb:Mgcracgap(gene name synonym)|uniprotkb:Male germ cell RacGap(gene name synonym)|uniprotkb:Racgap1(gene name)|psi-mi:Racgap1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001240737.1|refseq:NP_001240738.1|refseq:XP_011243948.1|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013423|reactome:R-MMU-983189|ensembl:ENSMUSG00000023015(gene)|ensembl:ENSMUST00000023756(transcript)|ensembl:ENSMUST00000171702(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008272"(sulfate transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|interpro:IPR000198(RhoGAP)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|refseq:NP_036155.1|dip:DIP-42340N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:Ya95AbWK+nGljvPWXuNWqGm3sqo10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q62074	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-82016|ensembl:ENSMUSP00000103884	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kpci_mouse(display_long)|uniprotkb:Prkci(gene name)|psi-mi:Prkci(display_short)|uniprotkb:nPKC-iota(gene name synonym)|uniprotkb:Atypical protein kinase C-lambda/iota(gene name synonym)|uniprotkb:Pkcl(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_032883.2|ensembl:ENSMUSG00000037643(gene)|ensembl:ENSMUST00000108249(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031252"(cell leading edge)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034661|interpro:IPR034877|mint:Q62074|rcsb pdb:4DC2|reactome:R-MMU-1912408|reactome:R-MMU-209543|reactome:R-MMU-420029|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|dip:DIP-32555N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:9q8JyZjufAVMLR0+uIK7y4nD9dI10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P31324	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-455340|uniprotkb:Q3UTZ1|uniprotkb:Q80ZM4|uniprotkb:Q8BRZ7|uniprotkb:B1B199|ensembl:ENSMUSP00000003079|ensembl:ENSMUSP00000039797	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kap3_mouse(display_long)|uniprotkb:Prkar2b(gene name)|psi-mi:Prkar2b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_035288.2|refseq:XP_006515077.1|dip:DIP-31571N|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P31324|rcsb pdb:3TNP|rcsb pdb:3TNQ|rcsb pdb:4WBB|rcsb pdb:4X6Q|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-432040|reactome:R-MMU-442720|reactome:R-MMU-5610787|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-983231|ensembl:ENSMUSG00000002997(gene)|ensembl:ENSMUST00000003079(transcript)|ensembl:ENSMUST00000036497(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007612"(learning)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0097332"(response to antipsychotic drug)|go:"GO:0097546"(ciliary base)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0097338"(response to clozapine)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:/d/0NSAnglWjmZAcQUn6ATpbJnE10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9CQR6	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-4286534|uniprotkb:A2ASL7|ensembl:ENSMUSP00000028087	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ppp6_mouse(display_long)|uniprotkb:Ppp6c(gene name)|psi-mi:Ppp6c(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_077171.1|ensembl:ENSMUSG00000026753(gene)|ensembl:ENSMUST00000028087(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:Q9CQR6|reactome:R-MMU-171319|reactome:R-MMU-204005|go:"GO:0006470"(protein dephosphorylation)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:R0jsZoqJLoRaSNMNCLRkQ40CC+o10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8K1N2	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-4286174|uniprotkb:Q3TNI3|uniprotkb:Q80Y16|uniprotkb:Q8BKV3|ensembl:ENSMUSP00000046496	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:phlb2_mouse(display_long)|uniprotkb:Ll5b(gene name synonym)|uniprotkb:Protein LL5-beta(gene name synonym)|uniprotkb:Phldb2(gene name)|psi-mi:Phldb2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_700461.2|refseq:NP_001239371.1|ensembl:ENSMUSG00000033149(gene)|ensembl:ENSMUST00000036355(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0031252"(cell leading edge)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045180"(basal cortex)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037810|mint:Q8K1N2|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:tiMY3xaHNbQUq8Jbxt3d9aiylYU10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8BX10	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-776241|uniprotkb:Q3UK19|uniprotkb:Q80VY8|uniprotkb:Q8BM78|uniprotkb:Q9CZU2|uniprotkb:B2RSM6|ensembl:ENSMUSP00000108124	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:pgam5_mouse(display_long)|uniprotkb:Pgam5(gene name)|psi-mi:Pgam5(display_short)|uniprotkb:Phosphoglycerate mutase family member 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001157010.1|refseq:NP_082549.2|dip:DIP-32064N|ensembl:ENSMUSG00000029500(gene)|ensembl:ENSMUST00000112505(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|mint:Q8BX10|reactome:R-MMU-8934903	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:m8AARXCf3lNoMo3JN7zcJNw5gwY10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q99NH2	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-6299697|uniprotkb:Q58T10|uniprotkb:Q58T11|uniprotkb:Q8CB21	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:pard3_mouse(display_long)|uniprotkb:Pard3(gene name)|psi-mi:Pard3(display_short)|uniprotkb:Par3(gene name synonym)|uniprotkb:Atypical PKC isotype-specific-interacting protein(gene name synonym)|uniprotkb:Ephrin-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001013598.1|refseq:NP_001013599.1|go:"GO:0008104"(protein localization)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043296"(apical junction complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|rcsb pdb:2KOH|rcsb pdb:2KOJ|reactome:R-MMU-2173791|reactome:R-MMU-420029|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003383"(apical constriction)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|dip:DIP-41727N|mint:Q99NH2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:T32+accBUmq14vv2OXj2mZe9fzQ10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8CH77	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732405|uniprotkb:Q3U5B6|uniprotkb:Q68EE8|uniprotkb:Q6PB78|uniprotkb:Q80TI7|uniprotkb:Q8BKG2|uniprotkb:Q8BUT5|ensembl:ENSMUSP00000043803|ensembl:ENSMUSP00000067241	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:nav1_mouse(display_long)|uniprotkb:Pore membrane and/or filament-interacting-like protein 3(gene name synonym)|uniprotkb:Nav1(gene name)|psi-mi:Nav1(display_short)|uniprotkb:Kiaa1151(gene name synonym)|uniprotkb:Pomfil3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_775613.2|ensembl:ENSMUSG00000009418(gene)|ensembl:ENSMUST00000040599(transcript)|ensembl:ENSMUST00000067414(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007399"(nervous system development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0043194"(axon initial segment)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR027417|interpro:IPR039041|mint:Q8CH77|go:"GO:0001578"(microtubule bundle formation)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:6JEY5QgG5i9X72Lw1SklaXm186U10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P12025	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16726312|ensembl:ENSMUSP00000028672|ensembl:ENSMUSP00000068413|ensembl:ENSMUSP00000088090|ensembl:ENSMUSP00000106941	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:mk_mouse(display_long)|uniprotkb:Retanoic acid-responsive protein(gene name synonym)|uniprotkb:Retinoic acid-induced differentiation factor(gene name synonym)|uniprotkb:Mdk(gene name)|psi-mi:Mdk(display_short)|uniprotkb:Mk(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000027239(gene)|ensembl:ENSMUST00000028672(transcript)|ensembl:ENSMUST00000069423(transcript)|ensembl:ENSMUST00000090602(transcript)|ensembl:ENSMUST00000111309(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007614"(short-term memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016477"(cell migration)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021681"(cerebellar granular layer development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030421"(defecation)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0042995"(cell projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044849"(estrous cycle)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0048477"(oogenesis)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071673"(positive regulation of smooth muscle cell chemotaxis)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:0106091"(glial cell projection elongation)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:1904036"(negative regulation of epithelial cell apoptotic process)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000762(PTN/MK heparin-binding protein)|interpro:IPR020089|interpro:IPR020090|interpro:IPR020091|interpro:IPR020092|interpro:IPR037122|interpro:IPR038130|refseq:NP_001012335.1|refseq:NP_001012336.1|refseq:NP_001278410.1|refseq:NP_034914.1|dip:DIP-5791N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:lf0KMWJoUzamS1IZ4O3zLc2Aarc10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P97820	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-644181	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:m4k4_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase kinase 4(gene name synonym)|uniprotkb:HPK/GCK-like kinase HGK(gene name synonym)|uniprotkb:Nck-interacting kinase(gene name synonym)|uniprotkb:Map4k4(gene name)|psi-mi:Map4k4(display_short)|uniprotkb:Nik(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001239129.1|refseq:NP_001239130.1|refseq:NP_001239131.1|refseq:NP_032722.2|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-2559580|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032014"(positive regulation of ARF protein signal transduction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-40973N|mint:P97820	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:laMTX6DrOoTz4D8zxLP5ohzqKyw10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9QXZ0	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-643248|intact:EBI-2658096|uniprotkb:B1ARU3|uniprotkb:Q4PLL5|uniprotkb:P97394|uniprotkb:P97395|uniprotkb:P97396	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:macf1_mouse(display_long)|uniprotkb:Actin cross-linking family 7(gene name synonym)|uniprotkb:Macf1(gene name)|psi-mi:Macf1(display_short)|uniprotkb:Acf7(gene name synonym)|uniprotkb:Aclp7(gene name synonym)|uniprotkb:Macf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR002017(Spectrin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR001101(Plectin repeat)|interpro:IPR018159|interpro:IPR001452(Src homology-3)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0008104"(protein localization)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|mint:Q9QXZ0|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:niJxpkI45VTa5x73A1tuX/aLXgo10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q61595	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-775369|uniprotkb:Q8BG49|uniprotkb:Q8BHF4|uniprotkb:Q8BHM8|uniprotkb:Q8C9Y5|uniprotkb:Q8CG51|uniprotkb:Q8CG52|uniprotkb:Q8CG53|uniprotkb:Q8CG54|uniprotkb:Q8CG55|uniprotkb:Q8CG56|uniprotkb:Q8CG57|uniprotkb:Q8CG58|uniprotkb:Q8CG59|uniprotkb:Q8CG60|uniprotkb:Q8CG61|uniprotkb:Q8CG62|uniprotkb:Q8CG63	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ktn1_mouse(display_long)|uniprotkb:Ktn1(gene name)|psi-mi:Ktn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_032503.2|refseq:NP_001280564.1|refseq:NP_001280565.1|interpro:IPR024854|refseq:NP_001334448.1|refseq:NP_001334449.1|refseq:NP_001334450.1|refseq:NP_001334452.1|refseq:NP_001334453.1|refseq:NP_001334454.1|refseq:NP_001334455.1|refseq:NP_001334456.1|refseq:NP_001334457.1|mint:Q61595|interpro:IPR007794(Ribosome receptor lysine or proline rich)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0015031"(protein transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|reactome:R-MMU-381426|reactome:R-MMU-5625970|reactome:R-MMU-8957275|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013408|reactome:R-MMU-9696264|reactome:R-MMU-9696270	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:xgS8/yfp5yj+gPyaC6a/gmSrxTA10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8BUL5	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732378|ensembl:ENSMUSP00000030841|uniprotkb:Q9CZP4	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:klhl7_mouse(display_long)|uniprotkb:Klhl7(gene name)|psi-mi:Klhl7(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000028986(gene)|ensembl:ENSMUST00000030841(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030599|refseq:NP_080724.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:WQwmtbG5V9aPsZa8nVlXE8wFzLU10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:B7ZNG0	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16356783|uniprotkb:B2RUB1	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kif7_mouse(display_long)|uniprotkb:Kif7(gene name)|psi-mi:Kif7(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	go:"GO:0003279"(cardiac septum development)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0035904"(aorta development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|go:"GO:0036064"(ciliary basal body)|reactome:R-MMU-5610787|reactome:R-MMU-5632684|dip:DIP-61761N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:WZ5rB98fyn0jmOSroekMVmjUZMM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P33174	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2553347|uniprotkb:Q80YP3|ensembl:ENSMUSP00000048383	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kif4_mouse(display_long)|uniprotkb:Kif4(gene name)|psi-mi:Kif4(display_short)|uniprotkb:Kif4a(gene name synonym)|uniprotkb:Kns4(gene name synonym)|uniprotkb:Chromokinesin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000034311(gene)|ensembl:ENSMUST00000048962(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0030496"(midbody)|go:"GO:0046872"(metal ion binding)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR033467|interpro:IPR036961|rcsb pdb:3ZFC|rcsb pdb:3ZFD|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-6811434|reactome:R-MMU-983189|refseq:NP_032472.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:5dvN3PnzCwzFNWsaCt8XWiaumqI10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:E9Q5G3	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2553152|uniprotkb:Q80V30|uniprotkb:Q99PT8|ensembl:ENSMUSP00000034815	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kif23_mouse(display_long)|uniprotkb:Kif23(gene name)|psi-mi:Kif23(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_077207.3|ensembl:ENSMUSG00000032254(gene)|ensembl:ENSMUST00000034815(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030496"(midbody)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR032384|interpro:IPR038105|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-68884|reactome:R-MMU-983189|go:"GO:0045171"(intercellular bridge)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:734bTofHqm+vN9dUUJ4YgpULwak10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9QXL1	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-911088|uniprotkb:E9PUY6|uniprotkb:P97424	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ki21b_mouse(display_long)|uniprotkb:Kinesin-like protein KIF6(gene name synonym)|uniprotkb:Kif21b(gene name)|psi-mi:Kif21b(display_short)|uniprotkb:Kif6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001034561.1|interpro:IPR019821|interpro:IPR001752(Kinesin, motor region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR027417|interpro:IPR027640|interpro:IPR036322|interpro:IPR036961|reactome:R-MMU-6811434|reactome:R-MMU-983189|reactome:R-MMU-2132295|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:1990939"	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:p5XA5tStORNyakd6slZvbCOfPfI10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6ZPU9	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-11102344|uniprotkb:Q7TPE0|uniprotkb:Q3TYD0|uniprotkb:Q8CFS7|uniprotkb:Q8BZE2|uniprotkb:Q80VQ5|uniprotkb:Q5BKR5|ensembl:ENSMUSP00000065160	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kbp_mouse(display_long)|uniprotkb:Kifbp(gene name)|psi-mi:Kifbp(display_short)|uniprotkb:KIF1-binding protein(gene name synonym)|uniprotkb:Kbp(gene name synonym)|uniprotkb:Kiaa1279(gene name synonym)|uniprotkb:Kif1bp(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_082473.2|ensembl:ENSMUSG00000036955(gene)|ensembl:ENSMUST00000065887(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007399"(nervous system development)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR022083	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:vxkF1gM5/VJ66ZS6qsf0UODxRz410090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8BIL5	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-4285715|uniprotkb:Q8BIZ2|uniprotkb:Q8K0P1|uniprotkb:Q8K454|uniprotkb:Q9CTN6|ensembl:ENSMUSP00000030306	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:hook1_mouse(display_long)|uniprotkb:Hook1(gene name)|psi-mi:Hook1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_084290.1|ensembl:ENSMUSG00000028572(gene)|ensembl:ENSMUST00000030306(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007030"(Golgi organization)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007286"(spermatid development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0030897"(HOPS complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:1905198"(manchette assembly)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|rcsb pdb:1WIX	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:9TPq3L1452DU5WxJT8JGhHpHwOY10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q99JP6	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-6272061|ensembl:ENSMUSP00000117033|uniprotkb:D3Z6N9|uniprotkb:Q9Z215	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:home3_mouse(display_long)|uniprotkb:Homer3(gene name)|psi-mi:Homer3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000003573(gene)|ensembl:ENSMUST00000140212(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q99JP6|reactome:R-MMU-6794361|refseq:NP_001139625.1|refseq:NP_036114.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:7IOPI8VTi6aKK/I0tl4AiUUIXIU10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P55937	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-647945|uniprotkb:Q80VF5|uniprotkb:Q8CCK4|uniprotkb:Q9QYT2|uniprotkb:Q9QYT3	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:goga3_mouse(display_long)|uniprotkb:Golgin-160(gene name synonym)|uniprotkb:Male-enhanced antigen 2(gene name synonym)|uniprotkb:Golga3(gene name)|psi-mi:Golga3(display_short)|uniprotkb:Mea2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_032172.3|interpro:IPR033288|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030154"(cell differentiation)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0090498"(extrinsic component of Golgi membrane)|reactome:R-MMU-9696270|go:"GO:0007283"(spermatogenesis)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:M2jyN71/zrgSF7nm1pYVLtWr9G410090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q61545	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-1606991|uniprotkb:Q9D2P0|ensembl:ENSMUSP00000078867	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ews_mouse(display_long)|uniprotkb:Ewsr1(gene name)|psi-mi:Ewsr1(display_short)|uniprotkb:Ews(gene name synonym)|uniprotkb:Ewsh(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_031994.2|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033109|interpro:IPR034869|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:Q61545|ensembl:ENSMUSG00000009079(gene)|ensembl:ENSMUST00000079949(transcript)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:bvajg+ZT71/K+6hwdHFdOewgvrw10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P84089	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2551866|ensembl:ENSMUSP00000021559|ensembl:ENSMUSP00000147411|uniprotkb:Q14259|uniprotkb:P70659	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:erh_mouse(display_long)|uniprotkb:Erh(gene name)|psi-mi:Erh(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000021131(gene)|ensembl:ENSMUSG00000063412(gene)|ensembl:ENSMUST00000021559(transcript)|ensembl:ENSMUST00000080152(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005634"(nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0034709"(methylosome)|interpro:IPR000781(Enhancer of rudimentary)|interpro:IPR035912|mint:P84089|rcsb pdb:1WWQ|rcsb pdb:1WZ7|refseq:NP_031977.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:foMOmvZ9wQyH0rrzBB2YlQhrT0g10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:O08810	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2550333|ensembl:ENSMUSP00000102675	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:u5s1_mouse(display_long)|uniprotkb:Eftud2(gene name)|psi-mi:Eftud2(display_short)|uniprotkb:Snrp116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000020929(gene)|ensembl:ENSMUST00000107060(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:O08810|reactome:R-MMU-72163|reactome:R-MMU-72165|refseq:NP_001103465.1|refseq:NP_035561.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:BXx/oB92nIw8mcrZHvpWc+E+DFA10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9JHU4	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-645061|uniprotkb:E9QM71|ensembl:ENSMUSP00000018851	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:dyhc1_mouse(display_long)|uniprotkb:Dhc1(gene name synonym)|uniprotkb:Dyhc(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:Dync1h1(gene name)|psi-mi:Dync1h1(display_short)|uniprotkb:Dnch1(gene name synonym)|uniprotkb:Dnchc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_084514.2|ensembl:ENSMUSG00000018707(gene)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002177"(manchette)|go:"GO:0003341"(cilium movement)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|ensembl:ENSMUST00000018851(transcript)|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|interpro:IPR042219|mint:Q9JHU4|rcsb pdb:3ERR|rcsb pdb:3J1T|rcsb pdb:3J1U|rcsb pdb:3WUQ|rcsb pdb:5AYH|rcsb pdb:6RZA|rcsb pdb:6RZB|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:sbED0xqQpe32T7I8ijeS3Xqlx7010090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q3U1J4	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2552275|ensembl:ENSMUSP00000025649|uniprotkb:Q99LV3|uniprotkb:Q9QYK0|uniprotkb:Q3U8G3|uniprotkb:Q9WV39|uniprotkb:Q3UJC4|uniprotkb:Q3U4D0	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ddb1_mouse(display_long)|uniprotkb:Ddb1(gene name)|psi-mi:Ddb1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000024740(gene)|ensembl:ENSMUST00000025649(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|refseq:NP_056550.1|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|mint:Q3U1J4|reactome:R-MMU-110314|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-8951664|go:"GO:0005654"(nucleoplasm)|dip:DIP-56812N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:dvNwCrG9In1FV2j/+PrsSMvqFnk10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:O88712	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-604547|ensembl:ENSMUSP00000078682|uniprotkb:Q3TAT1|uniprotkb:Q3TDL5|uniprotkb:Q3TUM5|uniprotkb:Q91WI6|uniprotkb:Q91YX3|uniprotkb:Q9QYG2	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ctbp1_mouse(display_long)|uniprotkb:Ctbp1(gene name)|psi-mi:Ctbp1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	go:"GO:0017053"(transcription repressor complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051287"(NAD binding)|go:"GO:0051726"(regulation of cell cycle)|ensembl:ENSMUSG00000037373(gene)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0098793"(presynapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099526"(presynapse to nucleus signaling pathway)|ensembl:ENSMUST00000079746(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029752|go:"GO:0003682"(chromatin binding)|interpro:IPR029753|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR036291|go:"GO:0005737"(cytoplasm)|interpro:IPR043322|go:"GO:0006342"|mint:O88712|reactome:R-MMU-3769402|reactome:R-MMU-3899300|reactome:R-MMU-4641265|go:"GO:0008134"(transcription factor binding)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|refseq:NP_001185788.1|refseq:NP_001185789.1|refseq:NP_001185790.1|refseq:NP_038530.1|refseq:NP_001297464.1|dip:DIP-33907N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:l2rq9ypazCscM/WbocEKgQZcEBo10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q569L8	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16417922|ensembl:ENSMUSP00000065949|ensembl:ENSMUSP00000153013|uniprotkb:E9QLP3	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:cenpj_mouse(display_long)|uniprotkb:Cenpj(gene name)|psi-mi:Cenpj(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	go:"GO:0019904"(protein domain specific binding)|go:"GO:0030954"(astral microtubule nucleation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0060271"(cilium assembly)|go:"GO:0061511"(centriole elongation)|go:"GO:0098534"(centriole assembly)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1903724"(positive regulation of centriole elongation)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:0019901"(protein kinase binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR009852(T-complex 10/CenJ, C-terminal)|interpro:IPR026581|interpro:IPR033068|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-6804115|reactome:R-MMU-8854518|ensembl:ENSMUSG00000064128(gene)|ensembl:ENSMUST00000065302(transcript)|ensembl:ENSMUST00000225951(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007099"(centriole replication)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0015631"(tubulin binding)|refseq:NP_001014996.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:gntjMVPctcBZ/EpS/1i3Qmj4m/M10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6RT24	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2553918|uniprotkb:Q6PD00|uniprotkb:Q7TPX4|uniprotkb:O35059|uniprotkb:Q3KQQ6|uniprotkb:Q80YB4|uniprotkb:Q3V044|uniprotkb:Q8BWX6	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:cenpe_mouse(display_long)|uniprotkb:Cenpe(gene name)|psi-mi:Cenpe(display_short)|uniprotkb:Centromere protein E(gene name synonym)|uniprotkb:Kinesin superfamily protein 10(gene name synonym)|uniprotkb:Motor domain of KIF10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_776123.3|interpro:IPR019821|interpro:IPR001752(Kinesin, motor region)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000940"(outer kinetochore)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0030496"(midbody)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0043515"(kinetochore binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050793"(regulation of developmental process)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0099606"(microtubule plus-end directed mitotic chromosome migration)|go:"GO:0099607"(lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|interpro:IPR027417|interpro:IPR036961|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-6811434|reactome:R-MMU-68877|reactome:R-MMU-983189|reactome:R-MMU-9648025	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:/B7yjM8DniJzyNgNUi7HEUDOQFk10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q5SNZ0	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-6271994|uniprotkb:Q5M6X2|uniprotkb:Q5M6X4|uniprotkb:Q5M6X5|uniprotkb:Q5SNZ1|uniprotkb:Q8C486|uniprotkb:Q8CFU7	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:grdn_mouse(display_long)|uniprotkb:Ccdc88a(gene name)|psi-mi:Ccdc88a(display_short)|uniprotkb:Grdn(gene name synonym)|uniprotkb:Kiaa1212(gene name synonym)|uniprotkb:Akt phosphorylation enhancer(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 88A(gene name synonym)|uniprotkb:G alpha-interacting vesicle-associated protein(gene name synonym)|uniprotkb:Girders of actin filament(gene name synonym)|uniprotkb:Hook-related protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030142"(COPI-coated Golgi to ER transport vesicle)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0072660"(maintenance of protein location in plasma membrane)|go:"GO:1903566"(positive regulation of protein localization to cilium)|reactome:R-MMU-9696264|reactome:R-MMU-9696273|interpro:IPR036872|refseq:XP_006514518.1|refseq:NP_789811.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR027717|interpro:IPR043936	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:hCoyY8kOqAAJYtIB6uzHpDMDfo010090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:D3YV10	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732359|ensembl:ENSMUSP00000114787	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ccd13_mouse(display_long)|uniprotkb:Ccdc13(gene name)|psi-mi:Ccdc13(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000079235(gene)|ensembl:ENSMUST00000135986(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042995"(cell projection)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR038929|refseq:NP_082660.1|refseq:XP_006511967.1|refseq:XP_011241227.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:Vz8LIcyfaA/txG2dumiptKjGuXw10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q80VC9	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2125556|uniprotkb:Q5DTW9|uniprotkb:Q8BUZ0|uniprotkb:E9Q5B0|uniprotkb:U5LGR7|uniprotkb:U5LGS1|uniprotkb:U5LGS5|uniprotkb:U5LGT0|uniprotkb:U5LHT8|uniprotkb:U5LHU4|uniprotkb:U5LHW1|uniprotkb:U5LHW4|uniprotkb:U5LHW9|uniprotkb:U5LK15|uniprotkb:U5LK19|uniprotkb:U5LK24|uniprotkb:U5LK70|uniprotkb:U5LK74|uniprotkb:U5LK79|ensembl:ENSMUSP00000058958	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:camp3_mouse(display_long)|uniprotkb:Marshalin(gene name synonym)|uniprotkb:Camsap3(gene name)|psi-mi:Camsap3(display_short)|uniprotkb:Protein Nezha(gene name synonym)|uniprotkb:Kiaa1543(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001157221.1|refseq:NP_081447.2|dip:DIP-52404N|refseq:NP_001334040.1|refseq:NP_001334041.1|refseq:NP_001334042.1|refseq:XP_006508937.1|refseq:XP_006508939.1|refseq:XP_006508941.1|ensembl:ENSMUSG00000044433(gene)|ensembl:ENSMUST00000057028(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003341"(cilium movement)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005915"(zonula adherens)|go:"GO:0005930"(axoneme)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030507"(spectrin binding)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031514"(motile cilium)|go:"GO:0033043"(regulation of organelle organization)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0036064"(ciliary basal body)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045218"(zonula adherens maintenance)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:1903358"(regulation of Golgi organization)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011033(PRC-barrel-like)|interpro:IPR014797(Protein of unknown function DUF1781)|interpro:IPR022613|interpro:IPR031372|interpro:IPR032940|interpro:IPR036872|interpro:IPR038209|mint:Q80VC9|rcsb pdb:1UGJ|rcsb pdb:5LZN|rcsb pdb:5M50|rcsb pdb:5OW5	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:Z30CkFi9SutmAZxuqpznPko7qZw10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:B2RQC6	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-3043834|ensembl:ENSMUSP00000013773|uniprotkb:B7ZN27	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:pyr1_mouse(display_long)|uniprotkb:Cad(gene name)|psi-mi:Cad(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000013629(gene)|ensembl:ENSMUST00000013773(transcript)|go:"GO:0002134"(UTP binding)|go:"GO:0004070"(aspartate carbamoyltransferase activity)|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004151"(dihydroorotase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014075"(response to amine)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016597"(amino acid binding)|go:"GO:0017144"|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0001889"(liver development)|go:"GO:0031000"(response to caffeine)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044205"('de novo' UMP biosynthetic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051414"(response to cortisol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR002082(Aspartate carbamoyltransferase, eukaryotic)|interpro:IPR002195(Dihydroorotase, conserved site)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|go:"GO:0019899"(enzyme binding)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR032466|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036901|interpro:IPR036914|mint:B2RQC6|reactome:R-MMU-500753|refseq:NP_076014.1|refseq:NP_001276451.1|dip:DIP-61412N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:t+qQw7me78vEm/Y4VBBhS8fmCsY10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q62036	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2553752|uniprotkb:B1AXJ0|ensembl:ENSMUSP00000101836	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:cp131_mouse(display_long)|uniprotkb:Cep131(gene name)|psi-mi:Cep131(display_short)|uniprotkb:5-azacytidine-induced protein 1(gene name synonym)|uniprotkb:Az1(gene name synonym)|uniprotkb:Azi(gene name synonym)|uniprotkb:Azi1(gene name synonym)|uniprotkb:Pre-acrosome localization protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_033864.3|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|ensembl:ENSMUSG00000039781(gene)|ensembl:ENSMUST00000106229(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002177"(manchette)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0120212"(sperm head-tail coupling apparatus)|go:"GO:1905198"(manchette assembly)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990953"(intramanchette transport)|interpro:IPR030465|mint:Q62036|refseq:XP_006532124.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:SHe8IbjKSkkDb2k8PSeZd8JPhKc10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q7TT18	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-1216367|uniprotkb:Q3TJ86|uniprotkb:Q3TZW1|uniprotkb:Q3UVK5|uniprotkb:Q3UYZ7|uniprotkb:Q80ZK7|uniprotkb:Q8C4A1|uniprotkb:Q9JK31|ensembl:ENSMUSP00000032335	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:mcaf1_mouse(display_long)|uniprotkb:Atf7ip(gene name)|psi-mi:Atf7ip(display_short)|uniprotkb:Mcaf1(gene name synonym)|uniprotkb:ATFa-associated modulator(gene name synonym)|uniprotkb:MBD1-containing chromatin-associated factor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_062299.2|refseq:XP_006506452.2|refseq:XP_017177170.1|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045898"(regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026085|interpro:IPR031870|interpro:IPR036116|mint:Q7TT18|reactome:R-MMU-3214841|ensembl:ENSMUSG00000030213(gene)|ensembl:ENSMUST00000032335(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:ZaghN26qtGUUIXwe2DJhonroU6E10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:E9PWM3	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732340|ensembl:ENSMUSP00000132914	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:e9pwm3_mouse(display_long)|uniprotkb:Armcx4(gene name)|psi-mi:Armcx4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000049804(gene)|ensembl:ENSMUST00000124226(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000225(Armadillo)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001189429.2|refseq:XP_006528531.1|refseq:XP_006528532.1|refseq:XP_006528533.1|refseq:XP_006528535.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:vv7gSeHPfJoUL4Jp9/JNPGmzc0w10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:O08583	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-6464301|ensembl:ENSMUSP00000026125|uniprotkb:Q0VBL5|uniprotkb:Q8CBM4|uniprotkb:Q9JJW7	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:thoc4_mouse(display_long)|uniprotkb:Alyref(gene name)|psi-mi:Alyref(display_short)|uniprotkb:Aly(gene name synonym)|uniprotkb:Ref1(gene name synonym)|uniprotkb:Refbp1(gene name synonym)|uniprotkb:THOC4(gene name synonym)|uniprotkb:Ally of AML-1 and LEF-1(gene name synonym)|uniprotkb:Aly/REF export factor(gene name synonym)|uniprotkb:REF1-I(gene name synonym)|uniprotkb:RNA and export factor-binding protein 1(gene name synonym)|uniprotkb:Transcriptional coactivator Aly/REF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000025134(gene)|ensembl:ENSMUST00000026125(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0051028"(mRNA transport)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR025715|interpro:IPR035979|mint:O08583|rcsb pdb:1NO8|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|refseq:NP_035698.1|dip:DIP-59977N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:DZAvcQrp7S1uipKsc/Wpxgb+gJI10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:A2ASQ1	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732264|ensembl:ENSMUSP00000101200|uniprotkb:A2ASP9|uniprotkb:A2ASQ0|uniprotkb:B2RWU1	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:agrin_mouse(display_long)|uniprotkb:Agrn(gene name)|psi-mi:Agrn(display_short)|uniprotkb:Agrin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0036122"(BMP binding)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1903277"(negative regulation of sodium ion export across plasma membrane)|go:"GO:1903407"("negative regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:2000541"(positive regulation of protein geranylgeranylation)|interpro:IPR000082(SEA)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036058|interpro:IPR036364|rcsb pdb:3PVE|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-3000178|reactome:R-MMU-975634|ensembl:ENSMUSG00000041936(gene)|ensembl:ENSMUST00000105575(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0032092"(positive regulation of protein binding)|refseq:XP_011248479.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:WJbobvxSWRhlor2OTMPSJ818FCM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9Z1D9	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732237|ensembl:ENSMUSP00000031632|uniprotkb:B9EIZ4|uniprotkb:Q3U4Z1|uniprotkb:Q9CYV9|uniprotkb:Q9CZG8	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:zn394_mouse(display_long)|uniprotkb:Zinc finger protein 94(gene name synonym)|uniprotkb:Zinc finger protein with KRAB and SCAN domains 14(gene name synonym)|uniprotkb:Znf394(gene name)|psi-mi:Znf394(display_short)|uniprotkb:Zfp94(gene name synonym)|uniprotkb:Zfp99(gene name synonym)|uniprotkb:Zkscan14(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000029627(gene)|ensembl:ENSMUST00000031632(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|interpro:IPR038269|reactome:R-MMU-212436|refseq:NP_075811.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:l4PrwP7WibonwY/bOhTR+F+rM7810090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:O88532	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-645485|uniprotkb:Q3TY30|uniprotkb:Q8BS85|uniprotkb:Q8CGG5|uniprotkb:Q91VZ0|uniprotkb:Q9CT34|ensembl:ENSMUSP00000118911	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:zfr_mouse(display_long)|uniprotkb:Zfr(gene name)|psi-mi:Zfr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_035897.2|ensembl:ENSMUSG00000022201(gene)|ensembl:ENSMUST00000122941(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:O88532	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:ncNwFUEUk0r2XotuXm/9Tt4iB5w10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8C6G8	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-4285076|uniprotkb:Q3TK81|uniprotkb:Q8C4F3|uniprotkb:Q8VDZ6|uniprotkb:E9PX83|ensembl:ENSMUSP00000124592	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:wdr26_mouse(display_long)|uniprotkb:Wdr26(gene name)|psi-mi:Wdr26(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_663489.4|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|ensembl:ENSMUSG00000038733(gene)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|ensembl:ENSMUST00000162819(transcript)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:n7KV+Q8UA8RP/yXbL9IdoevU+mE10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8R5H6	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-774719|uniprotkb:Q91W51|uniprotkb:Q9ERQ9|ensembl:ENSMUSP00000019975|ensembl:ENSMUSP00000101148	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:wasf1_mouse(display_long)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Wasf1(gene name)|psi-mi:Wasf1(display_short)|uniprotkb:Wave1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_114083.1|refseq:XP_006512995.1|ensembl:ENSMUSG00000019831(gene)|ensembl:ENSMUST00000019975(transcript)|ensembl:ENSMUST00000105509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8R5H6|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:t+4F2ap7lNjE/AGuIwMhel4YknU10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q0VGU4	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2013265|ensembl:ENSMUSP00000048273|ensembl:ENSMUSP00000140735|ensembl:ENSMUSP00000140815	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:vgf_mouse(display_long)|uniprotkb:Vgf(gene name)|psi-mi:Vgf(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:XP_017176427.1|refseq:XP_017176428.1|refseq:XP_006504497.1|refseq:XP_006504498.1|refseq:NP_001034474.1|refseq:XP_006504499.1|refseq:XP_006504500.1|refseq:XP_006504501.1|refseq:XP_006504502.1|refseq:XP_006504503.1|ensembl:ENSMUSG00000037428(gene)|ensembl:ENSMUST00000041543(transcript)|ensembl:ENSMUST00000186451(transcript)|ensembl:ENSMUST00000190827(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0008083"(growth factor activity)|go:"GO:0009409"(response to cold)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030073"(insulin secretion)|go:"GO:0030133"(transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032868"(response to insulin)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043084"(penile erection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0051591"(response to cAMP)|interpro:IPR026128|reactome:R-MMU-381426|reactome:R-MMU-8957275	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:sKDA/hvD1qnu1ORmxiJ/eRgD4gw10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:A2AN08	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-4285947|uniprotkb:A2AN07|uniprotkb:A2AN09|uniprotkb:A2AN10|uniprotkb:A2AN11|uniprotkb:Q52KI4|uniprotkb:Q6PB49|uniprotkb:Q6PFC7|uniprotkb:Q80Y11|uniprotkb:Q8BGB9|uniprotkb:Q8C3E8|uniprotkb:Q8C4W5|uniprotkb:Q8C8X7|uniprotkb:Q8CGE0|uniprotkb:Q8CHF3|ensembl:ENSMUSP00000095433	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ubr4_mouse(display_long)|uniprotkb:Kiaa0462(gene name synonym)|uniprotkb:Zubr1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Ubr4(gene name)|psi-mi:Ubr4(display_short)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:p600(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001153791.1|dip:DIP-61499N|ensembl:ENSMUSG00000066036(gene)|ensembl:ENSMUST00000097822(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:A2AN08|reactome:R-MMU-6798695|reactome:R-MMU-983168|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:dTpQoZkH0+rwfrguOvzwrbPh0+Y10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8BGG7	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8846415|uniprotkb:Q3U8Z2|uniprotkb:Q8BMW9|ensembl:ENSMUSP00000043865	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ubs3b_mouse(display_long)|uniprotkb:Ubash3b(gene name)|psi-mi:Ubash3b(display_short)|uniprotkb:Sts1(gene name synonym)|uniprotkb:Cbl-interacting protein p70(gene name synonym)|uniprotkb:Suppressor of T-cell receptor signaling 1(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 2(gene name synonym)|uniprotkb:Tyrosine-protein phosphatase STS1/TULA2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:XP_017169101.1|refseq:NP_789830.1|refseq:XP_006510700.1|ensembl:ENSMUSG00000032020(gene)|ensembl:ENSMUST00000044155(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0030168"(platelet activation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090331"(negative regulation of platelet aggregation)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035632|interpro:IPR036028|mint:Q8BGG7|rcsb pdb:2H0Q|rcsb pdb:2IKQ|rcsb pdb:3MBK	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:h0Mu6xceMTaoyJgWu+xhMTvNAds10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6PAM1	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732215|ensembl:ENSMUSP00000042153|ensembl:ENSMUSP00000081285|uniprotkb:Q6P1E5	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:txlna_mouse(display_long)|uniprotkb:Txlna(gene name)|psi-mi:Txlna(display_short)|uniprotkb:Txln(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000053841(gene)|ensembl:ENSMUST00000046425(transcript)|ensembl:ENSMUST00000084264(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR026183|reactome:R-MMU-449836|go:"GO:0019905"(syntaxin binding)|refseq:NP_001005506.2|refseq:NP_001186624.1|refseq:XP_006502722.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:huWnoXeA9iGVafCljuueXT2PmFA10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:E9Q512	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-11157440|ensembl:ENSMUSP00000021605	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:e9q512_mouse(display_long)|uniprotkb:Trip11(gene name)|psi-mi:Trip11(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_082722.1|ensembl:ENSMUSG00000021188(gene)|ensembl:ENSMUST00000021605(transcript)|go:"GO:0002079"(inner acrosomal membrane)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002081"(outer acrosomal membrane)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016607"(nuclear speck)|go:"GO:0031267"(small GTPase binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060348"(bone development)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0099041"(vesicle tethering to Golgi)|interpro:IPR000237(GRIP)|reactome:R-MMU-5620924|reactome:R-MMU-6811438	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:tRs6rekiQv5uotLQvKWQRksbleE10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9R1R2	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-775991|uniprotkb:Q3UMU5|ensembl:ENSMUSP00000053384|ensembl:ENSMUSP00000102401|ensembl:ENSMUSP00000114822	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:trim3_mouse(display_long)|uniprotkb:RING finger protein 22(gene name synonym)|uniprotkb:RING finger protein HAC1(gene name synonym)|uniprotkb:Trim3(gene name)|psi-mi:Trim3(display_short)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Rnf22(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001272799.1|refseq:NP_001272800.1|refseq:NP_001272802.1|refseq:NP_061368.1|ensembl:ENSMUSG00000036989(gene)|ensembl:ENSMUST00000057525(transcript)|ensembl:ENSMUST00000106789(transcript)|ensembl:ENSMUST00000147044(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001258(NHL repeat)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR017907|interpro:IPR027370|mint:Q9R1R2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:fOQH1BPgmOXrJXOb8VYYFpNX0UQ10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q62318	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-346909|uniprotkb:P70391|uniprotkb:Q8C283|uniprotkb:Q99PN4|ensembl:ENSMUSP00000005705	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:tif1b_mouse(display_long)|uniprotkb:Trim28(gene name)|psi-mi:Trim28(display_short)|uniprotkb:Krip1(gene name synonym)|uniprotkb:Tif1b(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:KRAB-A-interacting protein(gene name synonym)|uniprotkb:KRIP-1(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:Kap1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_035718.2|dip:DIP-31477N|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q62318|rcsb pdb:6O5K|reactome:R-MMU-212436|ensembl:ENSMUSG00000005566(gene)|ensembl:ENSMUST00000005705(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:DvGJxQNohVWs++QEAyrqe4ngcz810090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q8BYI9	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-774167|uniprotkb:A2RT70|uniprotkb:O88717|ensembl:ENSMUSP00000107298|ensembl:ENSMUSP00000141553	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:tenr_mouse(display_long)|uniprotkb:Restrictin(gene name synonym)|uniprotkb:Janusin(gene name synonym)|uniprotkb:Neural recognition molecule J1-160/180(gene name synonym)|uniprotkb:Tnr(gene name)|psi-mi:Tnr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_071707.2|refseq:XP_006496805.1|refseq:XP_006496806.1|refseq:XP_006496807.1|ensembl:ENSMUSG00000015829(gene)|ensembl:ENSMUST00000111669(transcript)|ensembl:ENSMUST00000192069(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0045121"(membrane raft)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048692"(negative regulation of axon extension involved in regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072534"(perineuronal net)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098966"(perisynaptic extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR033079|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:Q8BYI9|reactome:R-MMU-3000178	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:K7s7yPGS4RvIe+thCkAZIFGjNRA10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q3UKC1	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-644611|uniprotkb:Q91YT6|uniprotkb:Q9CVF0|uniprotkb:Q9DC45|ensembl:ENSMUSP00000079548	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:taxb1_mouse(display_long)|uniprotkb:Tax1bp1(gene name)|psi-mi:Tax1bp1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_080092.2|refseq:XP_006506432.1|ensembl:ENSMUSG00000004535(gene)|ensembl:ENSMUST00000080723(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q3UKC1|reactome:R-MMU-5357905|reactome:R-MMU-936440	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:tXfAygPlU98h9zHriu2WyD2mUG810090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:O55106	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2479958|uniprotkb:B2RWV9|uniprotkb:Q5BKR9|ensembl:ENSMUSP00000120830	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:strn_mouse(display_long)|uniprotkb:Strn(gene name)|psi-mi:Strn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000024077(gene)|ensembl:ENSMUST00000145910(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016358"(dendrite development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030425"(dendrite)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR013258(Striatin, N-terminal)|go:"GO:0014069"(postsynaptic density)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:O55106|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9009391|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_035630.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:tUJDyyIWZKuEBcyJKUIbk2dR4JE10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q99JB2	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-775583|uniprotkb:Q9DCG8|ensembl:ENSMUSP00000030169	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:stml2_mouse(display_long)|uniprotkb:Stoml2(gene name)|psi-mi:Stoml2(display_short)|uniprotkb:Slp2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_075720.1|ensembl:ENSMUSG00000028455(gene)|ensembl:ENSMUST00000030169(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010876"(lipid localization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051020"(GTPase binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1900210"(positive regulation of cardiolipin metabolic process)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1990046"(stress-induced mitochondrial fusion)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR032435|interpro:IPR036013|mint:Q99JB2|reactome:R-MMU-8949664	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:+dQT2qr5UcuuQo3aigecnCc0wgg10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:O54781	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-593325|uniprotkb:Q8VCD9	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:srpk2_mouse(display_long)|uniprotkb:Serine/arginine-rich protein-specific kinase 2(gene name synonym)|uniprotkb:SFRS protein kinase 2(gene name synonym)|uniprotkb:Srpk2(gene name)|psi-mi:Srpk2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	mint:O54781|refseq:NP_033300.2|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|refseq:XP_017176258.1|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000785"(chromatin)|go:"GO:0001525"(angiogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:w16BWU5PrwNUPMC4Yw83eDldbrA10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q62261	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P16546	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-911063|uniprotkb:A3KGU6|uniprotkb:Q8K380|uniprotkb:Q9CT05|uniprotkb:A3KGU8|ensembl:ENSMUSP00000092697	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:sptn1_mouse(display_long)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym)|uniprotkb:Spta2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	dip:DIP-37712N|ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000095083(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032437"(cuticular plate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:P16546|reactome:R-MMU-264870|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:UVB6Kv+PBlqDH3OLoGjxm5oYVPQ10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6NZL0	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-776265|uniprotkb:Q8BLM2|uniprotkb:Q9CSN3|uniprotkb:Q9CU45|ensembl:ENSMUSP00000090293	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:soga3_mouse(display_long)|uniprotkb:Soga3(gene name)|psi-mi:Soga3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_080414.2|ensembl:ENSMUSG00000038916(gene)|ensembl:ENSMUST00000092629(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|interpro:IPR027881	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:fqFLavYLqmaqDCGT+/GaB6l9h9U10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:A2AQ25	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-8821027|ensembl:ENSMUSP00000066170|uniprotkb:A2AUE9|uniprotkb:A2AUF0|uniprotkb:A2AUF1|uniprotkb:Q75UV8|uniprotkb:Q75UV9|uniprotkb:Q80VK2|uniprotkb:Q8BHX8|uniprotkb:Q8BHY1|uniprotkb:Q8CHA8|uniprotkb:Q8R0K6	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:skt_mouse(display_long)|uniprotkb:Skt(gene name)|psi-mi:Skt(display_short)|uniprotkb:Etl4(gene name synonym)|uniprotkb:Kiaa1217(gene name synonym)|uniprotkb:Enhancer trap locus 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	interpro:IPR022782|interpro:IPR026725|mint:A2AQ25|ensembl:ENSMUSG00000036617(gene)|ensembl:ENSMUST00000066509(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0048706"(embryonic skeletal system development)|refseq:NP_001074475.1|refseq:NP_001171101.2|refseq:NP_084171.2|refseq:NP_835160.2|refseq:XP_006497478.1|refseq:XP_006497487.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:WI45C2F/GFoa1PhVnBHPtxCj5mM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:D3YZU1	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2314988|ensembl:ENSMUSP00000103571	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:shan1_mouse(display_long)|uniprotkb:Shank1(gene name)|psi-mi:Shank1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001029287.1|refseq:XP_006540927.1|ensembl:ENSMUSG00000038738(gene)|ensembl:ENSMUST00000107938(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|reactome:R-MMU-6794361	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:TbxBmjjabypLqTlAx9zbkSAAzpk10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P55194	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-2642510|uniprotkb:E9QMQ2|uniprotkb:Q99KK8|ensembl:ENSMUSP00000001226|uniprotkb:A2A5V4	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:3bp1_mouse(display_long)|uniprotkb:Sh3bp1(gene name)|psi-mi:Sh3bp1(display_short)|uniprotkb:3bp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000022436(gene)|ensembl:ENSMUST00000001226(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030834"(regulation of actin filament depolymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000198(RhoGAP)|interpro:IPR004148(BAR)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267|mint:P55194|rcsb pdb:1ABO|reactome:R-MMU-9013149|refseq:NP_001303613.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:xZnGbYRBdoFCbDG2oFc9FfUrl1o10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6NZC7	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16730348|uniprotkb:Q8BXY6	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:s23ip_mouse(display_long)|uniprotkb:Sec23ip(gene name)|psi-mi:Sec23ip(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	reactome:R-MMU-204005|go:"GO:0001675"(acrosome assembly)|go:"GO:0004620"(phospholipase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR004177(DDHD)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:jWDkoDwfR19H5VAnGeT/9BDl0ZM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P26043	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-647737|uniprotkb:Q3TS85|uniprotkb:Q9QW27|ensembl:ENSMUSP00000000590|ensembl:ENSMUSP00000128249	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:radi_mouse(display_long)|uniprotkb:ESP10(gene name synonym)|uniprotkb:Rdx(gene name)|psi-mi:Rdx(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001098086.1|refseq:NP_033067.2|dip:DIP-29091N|ensembl:ENSMUSG00000032050(gene)|ensembl:ENSMUST00000000590(transcript)|ensembl:ENSMUST00000163153(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032420"(stereocilium)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0045176"(apical protein localization)|go:"GO:0045177"(apical part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903392"(negative regulation of adherens junction organization)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26043|rcsb pdb:1GC6|rcsb pdb:1GC7|rcsb pdb:1J19|rcsb pdb:2D10|rcsb pdb:2D11|rcsb pdb:2D2Q|rcsb pdb:2EMS|rcsb pdb:2EMT|rcsb pdb:2YVC|rcsb pdb:2ZPY|rcsb pdb:3X23|reactome:R-MMU-437239	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:d7wqsdTau9b92O3q6LW+/pyKL1w10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P69566	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-772305|uniprotkb:P84500|uniprotkb:Q3V136	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ranb9_mouse(display_long)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:B-cell antigen receptor Ig beta-associated protein 1(gene name synonym)|uniprotkb:Ranbp9(gene name)|psi-mi:Ranbp9(display_short)|uniprotkb:Ranbpm(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_064314.2|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|mint:P69566|interpro:IPR035782|interpro:IPR043136|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-MMU-373760|reactome:R-MMU-5673001|reactome:R-MMU-8851805	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:nKjsQ+KN8Z4mWEyQcRejUCLSDJY10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6VN19	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732190|ensembl:ENSMUSP00000159340|uniprotkb:Q69ZJ1|uniprotkb:Q8C328|uniprotkb:Q8R1E6	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:rbp10_mouse(display_long)|uniprotkb:Ranbp10(gene name)|psi-mi:Ranbp10(display_short)|uniprotkb:Kiaa1464(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000037415(gene)|ensembl:ENSMUST00000239468(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0048487"(beta-tubulin binding)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|rcsb pdb:5JIA|reactome:R-MMU-8851805|refseq:NP_665823.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:ooU6b/i/4Tm2Qb63l2lOReH22NU10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9JM13	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16369712|ensembl:ENSMUSP00000026390|ensembl:ENSMUSP00000114103|uniprotkb:Q3UIW0	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:rabx5_mouse(display_long)|uniprotkb:Rabex-5(gene name synonym)|uniprotkb:Rabgef1(gene name)|psi-mi:Rabgef1(display_short)|uniprotkb:Rabex5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000025340(gene)|ensembl:ENSMUST00000026390(transcript)|ensembl:ENSMUST00000119797(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0043305"(negative regulation of mast cell degranulation)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055037"(recycling endosome)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1900235"(negative regulation of Kit signaling pathway)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR037191|interpro:IPR041545|reactome:R-MMU-8876198|refseq:NP_001185988.1|refseq:NP_064367.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:HHqxqwWveCc5lJXLLNWOQU8V4/Y10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q91WG2	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-4286011|uniprotkb:Q3UMK8|uniprotkb:Q99KN3|ensembl:ENSMUSP00000102015	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:rabe2_mouse(display_long)|uniprotkb:Rabep2(gene name)|psi-mi:Rabep2(display_short)|uniprotkb:Rabpt5b(gene name synonym)|uniprotkb:Rabaptin-5beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_085043.2|ensembl:ENSMUSG00000030727(gene)|ensembl:ENSMUST00000106407(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0030030"(cell projection organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR003914(Rabaptin)|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|interpro:IPR018514|interpro:IPR029882	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:XFKyv669pq/6BsFIQfNzX/E1ntg10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:O35551	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-4286397|uniprotkb:A1L322|uniprotkb:Q99L08|uniprotkb:Q9CRP3|uniprotkb:Q9EQF9|uniprotkb:Q9JI94|uniprotkb:Q5QNU3|ensembl:ENSMUSP00000075619	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:rabe1_mouse(display_long)|uniprotkb:Rabep1(gene name)|psi-mi:Rabep1(display_short)|uniprotkb:Rab5ep(gene name synonym)|uniprotkb:Rabpt5(gene name synonym)|uniprotkb:Rabpt5a(gene name synonym)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_062273.2|refseq:NP_001278070.1|refseq:NP_001278071.1|refseq:NP_001278072.1|ensembl:ENSMUSG00000020817(gene)|ensembl:ENSMUST00000076270(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|interpro:IPR018514|interpro:IPR029880|mint:O35551	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:aheuMgAZ4SH4NEHk3VzjzwX+UG010090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:O35295	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-647544|ensembl:ENSMUSP00000136957	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:purb_mouse(display_long)|uniprotkb:Purine-rich element-binding protein B(gene name synonym)|uniprotkb:Vascular actin single-stranded DNA-binding factor 2 p44 component(gene name synonym)|uniprotkb:Purb(gene name)|psi-mi:Purb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	go:"GO:0030154"(cell differentiation)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSMUSG00000094483(gene)|ensembl:ENSMUST00000179343(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|refseq:NP_035351.1|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030499|mint:O35295	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:ZeoADmerELfkQ00oZ1w7a+wgQeA10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P42669	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-773823|ensembl:ENSMUSP00000059404	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:pura_mouse(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:Pura(gene name)|psi-mi:Pura(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_033015.1|refseq:XP_006525787.1|refseq:XP_011245162.1|ensembl:ENSMUSG00000043991(gene)|ensembl:ENSMUST00000051301(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:P42669	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:3LVZ5qdZYeJyeUVPhy3cozxROWs10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P63318	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-397096|uniprotkb:P05697|ensembl:ENSMUSP00000097874	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kpcg_mouse(display_long)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_035232.1|ensembl:ENSMUSG00000078816(gene)|ensembl:ENSMUST00000100301(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0005829"(cytosol)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|interpro:IPR020454|interpro:IPR035892|mint:P63318|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-416993|reactome:R-MMU-5099900|reactome:R-MMU-76005	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P68404	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P12367	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-645747	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kap2_mouse(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	rcsb pdb:3J4Q|rcsb pdb:3J4R|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rcsb pdb:1KMU|rcsb pdb:1KMW|rcsb pdb:1L6E|rcsb pdb:1R2A|rcsb pdb:2IZY|rcsb pdb:2QVS|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-5610787|reactome:R-MMU-983231|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:/SHXBtLe0gVa9Rf+boM1hNLRAms10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P68181	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-400685|uniprotkb:P05206|uniprotkb:Q3TQH5|uniprotkb:Q3UDD0|uniprotkb:Q3UTH5|ensembl:ENSMUSP00000099573	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kapcb_mouse(display_long)|uniprotkb:Prkacb(gene name)|psi-mi:Prkacb(display_short)|uniprotkb:Pkacb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001157670.1|refseq:NP_001157671.1|refseq:NP_001157672.1|refseq:NP_035230.1|ensembl:ENSMUSG00000005034(gene)|ensembl:ENSMUST00000102515(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0097338"(response to clozapine)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044109|mint:P68181|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356|reactome:R-MMU-432040|reactome:R-MMU-4420097|reactome:R-MMU-442720|reactome:R-MMU-5610785|reactome:R-MMU-5610787|reactome:R-MMU-5621575|reactome:R-MMU-5687128|reactome:R-MMU-8853659|reactome:R-MMU-8963896|reactome:R-MMU-983231	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:9278c8xZsjU90+vryXpzUc0y/G010090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q76MZ3	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-400413|ensembl:ENSMUSP00000007708	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:2aaa_mouse(display_long)|uniprotkb:Ppp2r1a(gene name)|psi-mi:Ppp2r1a(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_058587.1|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:Q76MZ3|rcsb pdb:2IAE|rcsb pdb:2PF4|rcsb pdb:3FGA|rcsb pdb:6EF4|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2995383|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-975957|ensembl:ENSMUSG00000007564(gene)|ensembl:ENSMUST00000007708(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051232"(meiotic spindle elongation)|dip:DIP-29429N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:0tnO11U1SNOOT46j23f7dim8O8k10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P60469	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-774674|uniprotkb:B8QI35|ensembl:ENSMUSP00000003961|ensembl:ENSMUSP00000148200	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:lipa3_mouse(display_long)|uniprotkb:Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3(gene name synonym)|uniprotkb:Ppfia3(gene name)|psi-mi:Ppfia3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:XP_006541336.1|refseq:XP_011249214.1|refseq:NP_084017.2|ensembl:ENSMUSG00000003863(gene)|ensembl:ENSMUST00000003961(transcript)|ensembl:ENSMUST00000211067(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0045202"(synapse)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050808"(synapse organization)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098875"(epididymosome)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR029515|interpro:IPR030440|interpro:IPR037620|interpro:IPR037621|interpro:IPR037622|rcsb pdb:4UWX|rcsb pdb:6KIP|rcsb pdb:6KR4|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-388844	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:5KJyS7thzh+Th0r52lh+DKeqOrA10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q68FH0	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16728261|ensembl:ENSMUSP00000099815|uniprotkb:A2AS46|uniprotkb:Q640N0|uniprotkb:Q68G56|uniprotkb:Q8BK47|uniprotkb:Q8BVH1|uniprotkb:Q9CRE3	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:pkp4_mouse(display_long)|uniprotkb:Armadillo-related protein(gene name synonym)|uniprotkb:Pkp4(gene name)|psi-mi:Pkp4(display_short)|uniprotkb:Armrp(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000026991(gene)|ensembl:ENSMUST00000102754(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0030496"(midbody)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|interpro:IPR028443|reactome:R-MMU-6805567|reactome:R-MMU-6809371|reactome:R-MMU-9696264|reactome:R-MMU-9696270|reactome:R-MMU-9696273|refseq:NP_080637.1|refseq:NP_780673.2|refseq:XP_006499234.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:OveWBfDD8W/RHcrE3K4AuVEXBSo10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9R0L6	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-4284371|uniprotkb:O70287|uniprotkb:Q3URH6|uniprotkb:Q7TMS7|uniprotkb:Q8C9V2|uniprotkb:Q91Y27|uniprotkb:Q91Y28|uniprotkb:Q91Y51|uniprotkb:Q9CRK8|uniprotkb:Q923L0|uniprotkb:Q9CT57|uniprotkb:E9QLK2|ensembl:ENSMUSP00000039709	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:pcm1_mouse(display_long)|uniprotkb:Pcm1(gene name)|psi-mi:Pcm1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_076151.2|refseq:XP_006509361.1|ensembl:ENSMUSG00000031592(gene)|ensembl:ENSMUST00000045218(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q9R0L6|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-380320	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:OT+ZOQY5pqQojMcLCWMIY+6zdl410090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9DBS9	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732162|ensembl:ENSMUSP00000110112|uniprotkb:E9QNI5	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:osbl3_mouse(display_long)|uniprotkb:Osbpl3(gene name)|psi-mi:Osbpl3(display_short)|uniprotkb:Orp3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000029822(gene)|ensembl:ENSMUST00000114468(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-MMU-192105|refseq:NP_001157117.1|refseq:NP_082157.2|refseq:XP_006506696.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:NzGQJDq0DKbAN8+o0/EKRb4RNNk10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P15116	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-397974|uniprotkb:Q64260|uniprotkb:Q6GU11|intact:EBI-2255565|ensembl:ENSMUSP00000025166	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:cadh2_mouse(display_long)|uniprotkb:Cdh2(gene name)|psi-mi:Cdh2(display_short)|uniprotkb:Neural cadherin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_031690.3|ensembl:ENSMUSG00000024304(gene)|ensembl:ENSMUST00000025166(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030315"(T-tubule)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|interpro:IPR027397|interpro:IPR030051|interpro:IPR039808|mint:P15116|rcsb pdb:1NCG|rcsb pdb:1NCH|rcsb pdb:1NCI|rcsb pdb:1NCJ|rcsb pdb:1OP4|rcsb pdb:2QVI|rcsb pdb:3Q2W|rcsb pdb:4NUM|rcsb pdb:4NUP|rcsb pdb:4NUQ|reactome:R-MMU-381426|reactome:R-MMU-418990|reactome:R-MMU-525793|reactome:R-MMU-8957275|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090497"(mesenchymal cell migration)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|go:"GO:0043005"(neuron projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|dip:DIP-31564N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:Yon1udPwyvjKP2+GVGUcrsZtFng10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P55288	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-15926945|ensembl:ENSMUSP00000074681	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:cad11_mouse(display_long)|uniprotkb:Cdh11(gene name)|psi-mi:Cdh11(display_short)|uniprotkb:Cad-11(gene name synonym)|uniprotkb:OSF-4(gene name synonym)|uniprotkb:Osteoblast cadherin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000031673(gene)|ensembl:ENSMUST00000075190(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0034332"(adherens junction organization)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR039808|rcsb pdb:2A4C|rcsb pdb:2A4E|rcsb pdb:6CGB|reactome:R-MMU-418990|refseq:NP_033996.4|refseq:XP_006530686.1|refseq:XP_006530687.1|refseq:XP_006530689.1|dip:DIP-59088N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:qgCbhesC9496btazK4+QQazuqfM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P70408	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16727790|ensembl:ENSMUSP00000042199|ensembl:ENSMUSP00000128782|uniprotkb:Q3UUB3|uniprotkb:Q80WS7	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:cad10_mouse(display_long)|uniprotkb:T2-cadherin(gene name synonym)|uniprotkb:Cdh10(gene name)|psi-mi:Cdh10(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000022321(gene)|ensembl:ENSMUST00000040562(transcript)|ensembl:ENSMUST00000166873(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0034332"(adherens junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR039808|rcsb pdb:6CG6|reactome:R-MMU-418990|refseq:NP_001303687.1|refseq:NP_033995.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:qcFZ51oDbh6HtvjWFmjiIAzscmM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:D3YZP9	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732031|ensembl:ENSMUSP00000123374	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:ccdc6_mouse(display_long)|uniprotkb:Ccdc6(gene name)|psi-mi:Ccdc6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000048701(gene)|ensembl:ENSMUST00000147545(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR019152|refseq:NP_001104591.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:9fVGTZBsEPgz+E9PKeXPrsmw39I10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6P9K8	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-771526|uniprotkb:Q6ZPU2|uniprotkb:Q8BWU2|uniprotkb:Q8BX99|uniprotkb:Q9CXH0|ensembl:ENSMUSP00000024958	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:cski1_mouse(display_long)|uniprotkb:CASK-interacting protein 1(gene name synonym)|uniprotkb:Caskin1(gene name)|psi-mi:Caskin1(display_short)|uniprotkb:Kiaa1306(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_082213.2|refseq:XP_006524378.1|ensembl:ENSMUSG00000033597(gene)|ensembl:ENSMUST00000024958(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001452(Src homology-3)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR027013|interpro:IPR032117|interpro:IPR032232|interpro:IPR035495|interpro:IPR035497|interpro:IPR035498|interpro:IPR036028|interpro:IPR036770|mint:Q6P9K8	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:zLkBAG7MLTXtMQ0HlY2ox2AumUE10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P28652	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P11798	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q6PAJ1	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-6271726|ensembl:ENSMUSP00000126377|uniprotkb:E9PZL3|uniprotkb:Q61339|uniprotkb:Q6ZPE5|uniprotkb:Q99LW5	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:bcr_mouse(display_long)|uniprotkb:Bcr(gene name)|psi-mi:Bcr(display_short)|uniprotkb:Kiaa3017(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000009681(gene)|ensembl:ENSMUST00000164107(transcript)|go:"GO:0002692"(negative regulation of cellular extravasation)|go:"GO:0003014"(renal system process)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043197"(dendritic spine)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051171"(regulation of nitrogen compound metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060268"(negative regulation of respiratory burst)|go:"GO:0060313"(negative regulation of blood vessel remodeling)|go:"GO:0065002"(intracellular protein transmembrane transport)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0014069"(postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000198(RhoGAP)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR015123(Bcr-Abl oncoprotein oligomerisation)|interpro:IPR035892|interpro:IPR035899|interpro:IPR036481|interpro:IPR037769|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_001074881.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:JTsOT1EJiIrOlQlKncjeKv6E7yM10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q9DBR3	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-16732013|uniprotkb:Q8BGV2|uniprotkb:Q8BUP3	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:armc8_mouse(display_long)|uniprotkb:Armc8(gene name)|psi-mi:Armc8(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	interpro:IPR038739|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034657"(GID complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:NP_001159610.1|refseq:NP_083044.2|reactome:R-MMU-6798695|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:/Yc2mQQJaQ0lLFVsOpA9cJcQrog10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q5SSM3	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-912106|uniprotkb:Q7TNB9|uniprotkb:Q5SSM4|uniprotkb:Q5SSM6|uniprotkb:Q5SSM7|uniprotkb:Q8BW90|intact:EBI-912134|ensembl:ENSMUSP00000090681	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:rhg44_mouse(display_long)|uniprotkb:Arhgap44(gene name)|psi-mi:Arhgap44(display_short)|uniprotkb:Rho-type GTPase-activating protein RICH2(gene name synonym)|uniprotkb:RhoGAP interacting with CIP4 homologs protein 2(gene name synonym)|uniprotkb:Rich2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001092758.1|refseq:NP_778168.2|refseq:XP_006532934.1|refseq:XP_006532935.1|ensembl:ENSMUSG00000033389(gene)|ensembl:ENSMUST00000093002(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035021"(negative regulation of Rac protein signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0055037"(recycling endosome)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0098886"(modification of dendritic spine)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099010"(modification of postsynaptic structure)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR004148(BAR)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:+JAFtLoTsRhKRLlYkxxLuzF1RtU10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q505D1	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-4286346|ensembl:ENSMUSP00000014640	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:anr28_mouse(display_long)|uniprotkb:Ankrd28(gene name)|psi-mi:Ankrd28(display_short)|uniprotkb:Ankyrin repeat domain-containing protein 28(gene name synonym)|uniprotkb:Phosphatase interactor targeting protein hnRNP K(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001019775.1|ensembl:ENSMUSG00000014496(gene)|ensembl:ENSMUST00000014640(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|reactome:R-MMU-171319|reactome:R-MMU-204005	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:jhZYM9tAWCCd4hV3c/YAyNi0Y3s10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q70FJ1	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-645887|uniprotkb:Q3TH74|uniprotkb:Q80TR6	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:akap9_mouse(display_long)|uniprotkb:Akap9(gene name)|psi-mi:Akap9(display_short)|uniprotkb:Kiaa0803(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_919444.2|interpro:IPR019528|interpro:IPR028745|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007165"(signal transduction)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034705"(potassium channel complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044307"(dendritic branch)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097729"(9+2 motile cilium)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0120219"(subapical part of cell)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903358"(regulation of Golgi organization)|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5576890|reactome:R-MMU-5576893|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:Q70FJ1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:9yyCeoX35wNULJg413iGM9TIQxA10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:Q3UHD9	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-771911|uniprotkb:Q5DU45|ensembl:ENSMUSP00000043466	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:agap2_mouse(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Kiaa0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	refseq:NP_001028435.1|refseq:NP_001287943.1|ensembl:ENSMUSG00000025422(gene)|ensembl:ENSMUST00000039259(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|go:"GO:0005768"(endosome)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:yq2lQtfk+FPqgT++CxAx2CS69nE10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q80YT7	uniprotkb:P60710	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	intact:EBI-353957|ensembl:ENSMUSP00000098066|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q3TI89|uniprotkb:Q3TVP6|uniprotkb:Q64316|uniprotkb:Q6ZWM3	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:actb_mouse(display_long)|uniprotkb:Actb(gene name)|psi-mi:Actb(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16732484|imex:IM-26285-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	ensembl:ENSMUSG00000029580(gene)|ensembl:ENSMUST00000100497(transcript)|refseq:NP_031419.1|go:"GO:0002102"(podosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60710|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5250924|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-5689603|reactome:R-MMU-5696394|reactome:R-MMU-8856828|reactome:R-MMU-9035034|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0070160"(tight junction)|go:"GO:0001725"(stress fiber)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|dip:DIP-31574N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc10090	rigid:wDT8oC1G1VU8tq/xrOi/GyPDGQA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q7TPH6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-1811542|uniprotkb:Q6PCM8|uniprotkb:E9PUJ6	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:mycb2_mouse(display_long)|uniprotkb:Mycbp2(gene name)|psi-mi:Mycbp2(display_short)|uniprotkb:Pam(gene name synonym)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)|uniprotkb:Pam/highwire/rpm-1 protein(gene name synonym)|uniprotkb:Protein Magellan(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR008979(Galactose-binding like)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR012983(PHR)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_997098.2|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR017868|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPH6|interpro:IPR038648|interpro:IPR003646(Bacterial SH3-like region)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|rcsb pdb:3GBW|rcsb pdb:3HWJ	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:LHdZ193Nhz4e+Iq5+Sua2QwrAWA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6PDG5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-3870565|uniprotkb:Q6P6P3|ensembl:ENSMUSP00000100868	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:smrc2_mouse(display_long)|uniprotkb:Smarcc2(gene name)|psi-mi:Smarcc2(display_short)|uniprotkb:Baf170(gene name synonym)|uniprotkb:BRG1-associated factor 170(gene name synonym)|uniprotkb:SWI/SNF complex 170 kDa subunit(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001107568.1|refseq:NP_001107569.1|refseq:NP_937803.1|dip:DIP-48884N|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0042393"(histone binding)|ensembl:ENSMUSG00000025369(gene)|go:"GO:0043044"|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000953(Chromo domain)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR007526(SWIRM)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR032448|interpro:IPR032450|interpro:IPR032451|interpro:IPR036388|interpro:IPR036420|interpro:IPR038044|mint:Q6PDG5|reactome:R-MMU-3214858|reactome:R-MMU-8939243|ensembl:ENSMUST00000105235(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:v8cjo/1nUFl5vd96cKMcY8LA8M010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9R0G7	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8412607|uniprotkb:Q6P9M5|intact:MINT-99176|ensembl:ENSMUSP00000069685|ensembl:ENSMUSP00000134747|ensembl:ENSMUSP00000134849	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:zeb2_mouse(display_long)|uniprotkb:Sip1(gene name synonym)|uniprotkb:Zfx1b(gene name synonym)|uniprotkb:Zfhx1b(gene name synonym)|uniprotkb:Zeb2(gene name)|psi-mi:Zeb2(display_short)|uniprotkb:Smad-interacting protein 1(gene name synonym)|uniprotkb:Zinc finger homeobox protein 1b(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:XP_011237404.1|refseq:NP_056568.2|refseq:NP_001276450.1|refseq:XP_017173550.1|refseq:XP_017173552.1|refseq:XP_017173554.1|ensembl:ENSMUSG00000026872(gene)|ensembl:ENSMUST00000068415(transcript)|ensembl:ENSMUST00000176438(transcript)|ensembl:ENSMUST00000177302(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0061373"(mammillary axonal complex development)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097324"(melanocyte migration)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1903056"(regulation of melanosome organization)|interpro:IPR001356(Homeobox)|interpro:IPR008598(Drought induced 19)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9R0G7	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	comment:mint|function:Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:5qzDeje4A1w1NfUsHC6/cWO8fiA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P52479	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8327299|uniprotkb:Q6ZQG9|uniprotkb:Q91VY7|uniprotkb:Q3TZB8|intact:MINT-1870263|uniprotkb:Q3U5E0|uniprotkb:Q3T9L4|uniprotkb:Q3TNN5|ensembl:ENSMUSP00000104616	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ubp10_mouse(display_long)|uniprotkb:Usp10(gene name)|psi-mi:Usp10(display_short)|uniprotkb:Ode-1(gene name synonym)|uniprotkb:Uchrp(gene name synonym)|uniprotkb:Kiaa0190(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001297559.1|refseq:NP_033488.1|ensembl:ENSMUSG00000031826(gene)|ensembl:ENSMUST00000108988(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:P52479|reactome:R-MMU-5656169|reactome:R-MMU-5689880	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	comment:mint|function:Ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:tdoxBRcosuC3GGqMGB5pBKA9pKc10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q91W18	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8329718|uniprotkb:Q8C1A4|uniprotkb:Q8BZW6|intact:UNK-5479555|intact:MINT-4137349|uniprotkb:E9Q2Q4|intact:UNK-5512156|uniprotkb:Q6NZG7|ensembl:ENSMUSP00000129019	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:tdrd3_mouse(display_long)|uniprotkb:Tdrd3(gene name)|psi-mi:Tdrd3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001240684.1|refseq:NP_766193.3|ensembl:ENSMUSG00000022019(gene)|ensembl:ENSMUST00000168275(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006397"(mRNA processing)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035145"(exon-exon junction complex)|interpro:IPR002999(Tudor)|interpro:IPR009060(UBA-like)|interpro:IPR010304(Survival motor neuron)|interpro:IPR013894(Region of unknown function DUF1767)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR033472|interpro:IPR041915|interpro:IPR042470|mint:Q91W18|rcsb pdb:2D9T	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:OJkc6E7+tTHuVr5BSCn8MtiApZk10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8K224	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8387859|intact:MINT-4117163|intact:UNK-5489633|uniprotkb:Q3UE04|uniprotkb:Q8BW78|uniprotkb:Q6ZPJ7|uniprotkb:Q80VD3|ensembl:ENSMUSP00000028608	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:nat10_mouse(display_long)|uniprotkb:18S rRNA cytosine acetyltransferase(gene name synonym)|uniprotkb:N-acetyltransferase 10(gene name synonym)|uniprotkb:Nat10(gene name)|psi-mi:Nat10(display_short)|uniprotkb:Kiaa1709(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_694766.1|ensembl:ENSMUSG00000027185(gene)|ensembl:ENSMUST00000028608(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0030496"(midbody)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051391"(tRNA acetylation)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0106162"(mRNA N-acetyltransferase activity)|go:"GO:1904812"(rRNA acetylation involved in maturation of SSU-rRNA)|go:"GO:1990883"(rRNA cytidine N-acetyltransferase activity)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR007807(Protein of unknown function DUF699, ATPase putative)|interpro:IPR013562(Region of unknown function DUF1726)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR027992|interpro:IPR032672|interpro:IPR033688|mint:Q8K224	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:aQypsoKWU81CbIbLIxupBf+a6J810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P21619	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8340638|intact:MINT-4100052|uniprotkb:P48680|uniprotkb:Q8CGB1|ensembl:ENSMUSP00000136524	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:lmnb2_mouse(display_long)|uniprotkb:Lmnb2(gene name)|psi-mi:Lmnb2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001334069.1|refseq:NP_034852.2|ensembl:ENSMUSG00000062075(gene)|ensembl:ENSMUST00000179022(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P21619	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	function:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:s8kNScxQWheNZ5Yu1h/5R+lvb9I10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9WVR4	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8572772|uniprotkb:Q9WVR5|intact:UNK-5560063	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:fxr2_mouse(display_long)|uniprotkb:Fxr2(gene name)|psi-mi:Fxr2(display_short)|uniprotkb:Fxr2h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR032172|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0045182"(translation regulator activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR022034|interpro:IPR008395(Agenet)|interpro:IPR004088(K Homology, type 1)|interpro:IPR040472|interpro:IPR040148|interpro:IPR036612|interpro:IPR041560	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	function:RNA-binding protein|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:q56uykuU0MnJ8r9/CdCuFG+ML0M10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q61584	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8VEH5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8317423|ensembl:ENSMUSP00000052904|ensembl:ENSMUSP00000120245|intact:MINT-4094544|uniprotkb:Q80TS4	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:epmip_mouse(display_long)|uniprotkb:Epm2aip1(gene name)|psi-mi:Epm2aip1(display_short)|uniprotkb:Kiaa0766(gene name synonym)|uniprotkb:Laforin-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000046785(gene)|ensembl:ENSMUST00000060711(transcript)|ensembl:ENSMUST00000135807(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR026630|interpro:IPR040647|mint:Q8VEH5|refseq:NP_780475.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:Moh1l/PjRcvRTBqsTbINe9OJKvs10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q61315	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-7848277|uniprotkb:Q62044|intact:UNK-5461725	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:apc_mouse(display_long)|uniprotkb:Apc(gene name)|psi-mi:Apc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0001822"(kidney development)|go:"GO:0001942"(hair follicle development)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009798"(axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042483"(negative regulation of odontogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043588"(skin development)|go:"GO:0044295"(axonal growth cone)|go:"GO:0031253"(cell projection membrane)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044337"(canonical Wnt signaling pathway involved in positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051171"(regulation of nitrogen compound metabolic process)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070852"(cell body fiber)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000211"(regulation of glutamate metabolic process)|rcsb pdb:1VJ6|reactome:R-MMU-111465|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3769402|reactome:R-MMU-4641262|reactome:R-MMU-5689896|interpro:IPR032038|mint:Q61315|interpro:IPR009224(SAMP)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009232(EB-1 binding)|interpro:IPR026818|interpro:IPR011989(Armadillo-like helical)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR026836|interpro:IPR036149|interpro:IPR041257	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	function:Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. APC activity is correlated with its phosphorylation state|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:5LB5NjRyV0VFe8xzCkg3/o+44g410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9Z103	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8338941|uniprotkb:A2BDX0|intact:MINT-4087285|ensembl:ENSMUSP00000056809|ensembl:ENSMUSP00000085316	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:adnp_mouse(display_long)|uniprotkb:Adnp(gene name)|psi-mi:Adnp(display_short)|uniprotkb:Activity-dependent neuroprotective protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001297015.1|refseq:NP_033758.2|ensembl:ENSMUSG00000051149(gene)|ensembl:ENSMUST00000057793(transcript)|ensembl:ENSMUST00000088001(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007614"(short-term memory)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0042277"(peptide binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044849"(estrous cycle)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR038861|mint:Q9Z103	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	function:Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:PSS9JEDZ+k4ClBvuqSKHNm9a+Z410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q3UTJ2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8345744|uniprotkb:Q80TS1|intact:MINT-1853612|uniprotkb:Q3USC6|uniprotkb:Q8BX47|uniprotkb:Q8CHU0|uniprotkb:Q8BLW9|intact:MINT-4116161|uniprotkb:Q8BJL6|uniprotkb:Q8BJU3	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:srbs2_mouse(display_long)|uniprotkb:Sorbs2(gene name)|psi-mi:Sorbs2(display_short)|uniprotkb:Arg/Abl-interacting protein 2(gene name synonym)|uniprotkb:Argbp2(gene name synonym)|uniprotkb:Kiaa0777(gene name synonym)|uniprotkb:Arg-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001297636.1|interpro:IPR003127(Sorbin-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR028506|interpro:IPR036028|mint:Q3UTJ2|refseq:XP_006509449.1|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR001452(Src homology-3)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	comment:"fragmentation type: fragment"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:2sKDQux/2IV7mW8l6LK36D3qlqw10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8C0T5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8334367|uniprotkb:Q6PDI8|uniprotkb:Q80U02|uniprotkb:Q8C026|intact:MINT-4134650|ensembl:ENSMUSP00000061014|ensembl:ENSMUSP00000131030|ensembl:ENSMUSP00000152212	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:si1l1_mouse(display_long)|uniprotkb:Sipa1l1(gene name)|psi-mi:Sipa1l1(display_short)|uniprotkb:Kiaa0440(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:XP_011242371.1|refseq:NP_001161455.1|refseq:NP_766167.2|refseq:XP_017170514.1|ensembl:ENSMUSG00000042700(gene)|ensembl:ENSMUST00000053969(transcript)|ensembl:ENSMUST00000166429(transcript)|ensembl:ENSMUST00000222714(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021818|interpro:IPR030770|interpro:IPR035974|interpro:IPR036034|mint:Q8C0T5	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:x21vMrPCtOFn87Vqj7XcrK6DJZw10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8CFI0	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8046183|uniprotkb:Q8BS42|uniprotkb:Q8BRT9|intact:MINT-5097552|uniprotkb:Q99PK2	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ned4l_mouse(display_long)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:Nedd4l(gene name)|psi-mi:Nedd4l(display_short)|uniprotkb:Kiaa0439(gene name synonym)|uniprotkb:Nedd4b(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	dip:DIP-48843N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0009651"(response to salt stress)|go:"GO:0010038"(response to metal ion)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:1WR3|rcsb pdb:1WR4|rcsb pdb:1WR7|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-MMU-2173795|reactome:R-MMU-2672351|reactome:R-MMU-983168	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	comment:mint|function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:rne2aA4b/xoATCErEBuu9uK3Zxk10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9JLB2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-7352463|intact:MINT-1206544|ensembl:ENSMUSP00000080683	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:pals1_mouse(display_long)|uniprotkb:Pals1(gene name)|psi-mi:Pals1(display_short)|uniprotkb:MAGUK p55 subfamily member 5(gene name synonym)|uniprotkb:Mpp5(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_062525.1|ensembl:ENSMUSG00000021112(gene)|ensembl:ENSMUST00000082024(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032288"(myelin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043204"(perikaryon)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0045177"(apical part of cell)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q9JLB2|rcsb pdb:1VA8|rcsb pdb:1VF6|refseq:XP_006516160.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	comment:mint|function:May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of VIL2 to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:YJ2sctzj4kgFJL0xae5I75lOHcc10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8C008	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8317102|uniprotkb:Q8C060|intact:MINT-4113786|uniprotkb:A2AN93|ensembl:ENSMUSP00000080643	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dzan1_mouse(display_long)|uniprotkb:Dzank1(gene name)|psi-mi:Dzank1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_766447.2|ensembl:ENSMUSG00000037259(gene)|ensembl:ENSMUST00000081982(transcript)|go:"GO:0046872"(metal ion binding)|interpro:IPR025874|interpro:IPR026876|interpro:IPR036770|mint:Q8C008	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:ozGQu95/TVKGDwRgLlTCq+bl3PM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:F6ZDS4	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8317182|intact:MINT-4119134|uniprotkb:Q8R4A0|uniprotkb:Q921B9|ensembl:ENSMUSP00000117616	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:tpr_mouse(display_long)|uniprotkb:Tpr(gene name)|psi-mi:Tpr(display_short)|uniprotkb:NPC-associated intranuclear protein(gene name synonym)|uniprotkb:Translocated promoter region and nuclear basket protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_598541.3|ensembl:ENSMUSG00000006005(gene)|ensembl:ENSMUST00000124973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003682"(chromatin binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006404"(RNA import into nucleus)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010965"(regulation of mitotic sister chromatid separation)|go:"GO:0015631"(tubulin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR012929(Tetratricopeptide, MLP1/MLP2-like)|mint:F6ZDS4|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822|reactome:R-MMU-191859|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-4615885|reactome:R-MMU-5578749	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	comment:"fragmentation type: fragment"|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:tP8N2Pd6AcwYnEHlsKU6zt3Ess410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P58404	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8311487|ensembl:ENSMUSP00000019220|uniprotkb:Q68EF5|intact:MINT-4135943|uniprotkb:E9QKX6	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:strn4_mouse(display_long)|uniprotkb:Strn4(gene name)|psi-mi:Strn4(display_short)|uniprotkb:Zin(gene name synonym)|uniprotkb:Zinedin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR013258(Striatin, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P58404|go:"GO:0032991"(protein-containing complex)|ensembl:ENSMUSG00000030374(gene)|ensembl:ENSMUST00000019220(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|refseq:NP_598550.2|refseq:NP_001034967.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	function:Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:g82nHtjLiKufUNKKCq0dsdoowg810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P62715	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8028975|uniprotkb:P11082|intact:UNK-5382027|ensembl:ENSMUSP00000009774	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:pp2ab_mouse(display_long)|uniprotkb:Ppp2cb(gene name)|psi-mi:Ppp2cb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_059070.1|ensembl:ENSMUSG00000009630(gene)|ensembl:ENSMUST00000009774(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P62715|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-9648025	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	function:PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase|comment:mint|comment:homomint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q811P8	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-6949116|ensembl:ENSMUSP00000133898|intact:MINT-268399|uniprotkb:B9EHJ8|uniprotkb:Q6A010	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:rhg32_mouse(display_long)|uniprotkb:RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling(gene name synonym)|uniprotkb:Rics(gene name synonym)|uniprotkb:p200RhoGAP(gene name synonym)|uniprotkb:p250GAP(gene name synonym)|uniprotkb:Arhgap32(gene name)|psi-mi:Arhgap32(display_short)|uniprotkb:Brain-specific Rho GTPase-activating protein(gene name synonym)|uniprotkb:GAB-associated Cdc42/Rac GTPase-activating protein(gene name synonym)|uniprotkb:GC-GAP(gene name synonym)|uniprotkb:Grit(gene name synonym)|uniprotkb:Kiaa0712(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 32(gene name synonym)|uniprotkb:Rho/Cdc42/Rac GTPase-activating protein RICS(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000041444(gene)|ensembl:ENSMUST00000174641(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001650"(fibrillar center)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005938"(cell cortex)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0043197"(dendritic spine)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036028|interpro:IPR036871|interpro:IPR042139|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-9035034|refseq:NP_796353.3|refseq:NP_001182561.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:4ZVZeciVms1xmC18riIhaDt9wMY10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9CU65	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2312762|uniprotkb:Q3UUZ8|uniprotkb:Q3UXK7|uniprotkb:Q80XP0|uniprotkb:B2RUS2|ensembl:ENSMUSP00000022511	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:zmym2_mouse(display_long)|uniprotkb:Zmym2(gene name)|psi-mi:Zmym2(display_short)|uniprotkb:Zfp198(gene name synonym)|uniprotkb:Znf198(gene name synonym)|uniprotkb:Zinc finger protein 198(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:XP_006519728.1|refseq:NP_083774.2|refseq:XP_017171710.1|dip:DIP-29928N|ensembl:ENSMUSG00000021945(gene)|ensembl:ENSMUST00000022511(transcript)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016605"(PML body)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|interpro:IPR010507(Zinc finger, MYM-type)|interpro:IPR011017(TRASH)|interpro:IPR021893|mint:Q9CU65	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:gIm0LYQWUamVGDkVsYWlgKrzePw10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q62520	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-308076	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:zic2_mouse(display_long)|uniprotkb:Zic2(gene name)|psi-mi:Zic2(display_short)|uniprotkb:Zinc finger protein of the cerebellum 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001843"(neural tube closure)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041643	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:wwSPtlbx7Gsi3R4AgFSa8uRY8B410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:B1AWL2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-5710090|intact:EBI-16734028|uniprotkb:A2SW42|ensembl:ENSMUSP00000095677	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:zn462_mouse(display_long)|uniprotkb:Znf462(gene name)|psi-mi:Znf462(display_short)|uniprotkb:Zfp462(gene name synonym)|uniprotkb:Zinc finger PBX1-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_766455.2|ensembl:ENSMUSG00000060206(gene)|ensembl:ENSMUST00000098070(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:B1AWL2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:afh6qNp5fP7ayVIT0G49FBhTgNo10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6IQX8	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-3044006|ensembl:ENSMUSP00000068184|ensembl:ENSMUSP00000126854|ensembl:ENSMUSP00000154709|uniprotkb:Q921W9|uniprotkb:Q924S6|uniprotkb:Q9CVF3|intact:EBI-3508329	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:zn219_mouse(display_long)|uniprotkb:Znf219(gene name)|psi-mi:Znf219(display_short)|uniprotkb:Zfp219(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000049295(gene)|ensembl:ENSMUST00000067549(transcript)|ensembl:ENSMUST00000166169(transcript)|ensembl:ENSMUST00000226522(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0060174"(limb bud formation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q6IQX8|refseq:XP_011243478.1|refseq:XP_011243479.1|refseq:XP_017171669.1|refseq:NP_081524.2|refseq:NP_001240623.1|refseq:NP_001240624.1|refseq:XP_006519561.1|refseq:XP_006519562.1|refseq:XP_006519564.1|refseq:XP_006519565.1|refseq:XP_006519566.1|refseq:XP_006519567.1|refseq:XP_006519568.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:Q6ebFbVDwgd46TS1dBOEk3kNYO410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6ZPZ3	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16734011	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:zc3h4_mouse(display_long)|uniprotkb:Zc3h4(gene name)|psi-mi:Zc3h4(display_short)|uniprotkb:Kiaa1064(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR036855|interpro:IPR041367|go:"GO:0005829"(cytosol)|refseq:NP_941033.2|refseq:XP_006540165.1|refseq:XP_006540169.1|refseq:XP_006540170.1|refseq:XP_006540171.1|refseq:XP_017177799.1|dip:DIP-61658N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:PK2zD3OkuLCTiGbeqPpECUSQpyM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:O88286	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-5737907|uniprotkb:O88287|uniprotkb:Q1XG03|uniprotkb:Q3UZX7|uniprotkb:Q7TSJ4|uniprotkb:Q9CT89	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:wiz_mouse(display_long)|uniprotkb:Wiz(gene name)|psi-mi:Wiz(display_short)|uniprotkb:Widely-interspaced zinc finger-containing protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_035847.2|refseq:NP_997603.3|interpro:IPR036236|mint:O88286|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|refseq:XP_017172890.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0030496"(midbody)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0070984"(SET domain binding)|go:"GO:1990226"(histone methyltransferase binding)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:j0wvtBTYwyK+J28wfdr5/bYEtQc10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q80WC1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-3043986|ensembl:ENSMUSP00000124043|uniprotkb:Q69Z27|uniprotkb:Q80ZZ9|uniprotkb:Q8BQ40|uniprotkb:Q8BRI2	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ubn2_mouse(display_long)|uniprotkb:Ubn2(gene name)|psi-mi:Ubn2(display_short)|uniprotkb:Kiaa2030(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000038538(gene)|ensembl:ENSMUST00000160583(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR014840("Histone promoter control 2 (HPC2)")|interpro:IPR026943|interpro:IPR026947|mint:Q80WC1|refseq:NP_796159.3	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:vcAa7JBQlOuyAjItcs7E0udEz9Y10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q0KL02	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16725543|uniprotkb:Q3U522|uniprotkb:Q6P9K6|uniprotkb:Q80W23	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:trio_mouse(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-MMU-193648|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418885|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|mint:Q0KL02|refseq:NP_001074771.1|refseq:XP_006520117.1|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|interpro:IPR028570	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:nUVpjuymw6gIq+G/H2xcZJh55a810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:O55047	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733969|ensembl:ENSMUSP00000015107|ensembl:ENSMUSP00000102552|uniprotkb:B1ASU7|uniprotkb:B1ASU8|uniprotkb:Q9D5Y5	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:tlk2_mouse(display_long)|uniprotkb:PKU-alpha(gene name synonym)|uniprotkb:Tousled-like kinase 2(gene name synonym)|uniprotkb:Tlk2(gene name)|psi-mi:Tlk2(display_short)|uniprotkb:Tlk(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000020694(gene)|ensembl:ENSMUST00000015107(transcript)|ensembl:ENSMUST00000106939(transcript)|go:"GO:0001672"(regulation of chromatin assembly or disassembly)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005882"(intermediate filament)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027086|refseq:NP_001281260.1|refseq:NP_001281263.1|refseq:XP_011247316.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:onMeSWxIXvk+GvGzZfyepGglZlM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q569Z6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2536252|ensembl:ENSMUSP00000079722	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:tr150_mouse(display_long)|uniprotkb:Thrap3(gene name)|psi-mi:Thrap3(display_short)|uniprotkb:Trap150(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 150 kDa component(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000043962(gene)|ensembl:ENSMUST00000080919(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR026667|interpro:IPR029199|go:"GO:0008380"(RNA splicing)|refseq:XP_011238805.1|refseq:NP_666265.3|refseq:XP_006503104.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:Cb0vHuEX3Ew27z2gvfC/36tdeYE10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8BHJ5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-1216384|uniprotkb:Q3UWL6|uniprotkb:Q8CBG4|uniprotkb:Q8VEG3|uniprotkb:Q9EQD4|ensembl:ENSMUSP00000067164|ensembl:ENSMUSP00000141363|ensembl:ENSMUSP00000142184|ensembl:ENSMUSP00000144436	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:tbl1r_mouse(display_long)|uniprotkb:Tbl1xr1(gene name)|psi-mi:Tbl1xr1(display_short)|uniprotkb:Ira1(gene name synonym)|uniprotkb:Tblr1(gene name synonym)|uniprotkb:Transducin beta-like 1X-related protein 1(gene name synonym)|uniprotkb:Nuclear receptor corepressor/HDAC3 complex subunit TBLR1(gene name synonym)|uniprotkb:TBL1-related protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_109657.2|refseq:XP_011248020.1|refseq:XP_011248023.1|refseq:XP_011248021.1|refseq:XP_006535642.1|refseq:XP_006535643.1|refseq:XP_017175306.1|dip:DIP-38606N|ensembl:ENSMUSG00000027630(gene)|ensembl:ENSMUST00000063988(transcript)|ensembl:ENSMUST00000192328(transcript)|ensembl:ENSMUST00000193734(transcript)|ensembl:ENSMUST00000202747(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0002021"(response to dietary excess)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042393"(histone binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060613"(fat pad development)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q8BHJ5|rcsb pdb:5NAF|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-9029569|reactome:R-MMU-9707564	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:yq19+P14lXTgaMDi8JXFd5B2dic10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8C092	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-12667248|uniprotkb:Q8BTR2	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:taf5_mouse(display_long)|uniprotkb:Taf5(gene name)|psi-mi:Taf5(display_short)|uniprotkb:Transcription initiation factor TFIID 100 kDa subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_796316.2|interpro:IPR020472|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|reactome:R-MMU-674695|reactome:R-MMU-6804756|reactome:R-MMU-6807505|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-76042|interpro:IPR037783|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR007582(WD40 associated region in TFIID subunit)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037264	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:iDpKf85r1pKLAdwDOwZtaDaePHs10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6ZWQ0	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-11517168|uniprotkb:Q640M5|ensembl:ENSMUSP00000047697	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:syne2_mouse(display_long)|uniprotkb:Nuclear envelope spectrin repeat protein 2(gene name synonym)|uniprotkb:Nucleus and actin connecting element protein(gene name synonym)|uniprotkb:Synaptic nuclear envelope protein 2(gene name synonym)|uniprotkb:KASH domain-containing protein 2(gene name synonym)|uniprotkb:Syne2(gene name)|psi-mi:Syne2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	dip:DIP-61049N|refseq:NP_001005510.2|ensembl:ENSMUSG00000063450(gene)|ensembl:ENSMUST00000044217(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0005739"(mitochondrion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031981"(nuclear lumen)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0007097"(nuclear migration)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051642"(centrosome localization)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR012315(Klarsicht/ANC-1/syne-1 homology)|interpro:IPR018159|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|interpro:IPR030266|interpro:IPR036872|mint:Q6ZWQ0	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:dByvgsaISSaQdpGCQahK7a5mG2w10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q920B9	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2549823|uniprotkb:Q3TZ48|uniprotkb:Q3UFH0|uniprotkb:Q921H4	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:sp16h_mouse(display_long)|uniprotkb:Supt16h(gene name)|psi-mi:Supt16h(display_short)|uniprotkb:Fact140(gene name synonym)|uniprotkb:Factp140(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex subunit SPT16(gene name synonym)|uniprotkb:FACT 140 kDa subunit(gene name synonym)|uniprotkb:FACTp140(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 140 kDa subunit(gene name synonym)|uniprotkb:Supt16(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034724"(DNA replication-independent chromatin organization)|go:"GO:0035101"(FACT complex)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR029149|interpro:IPR033825|interpro:IPR036005|interpro:IPR040258|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-6796648|interpro:IPR029148|reactome:R-MMU-6804756|reactome:R-MMU-75955|interpro:IPR013953(FACT complex subunit Spt16p/Cdc68p)|refseq:NP_291096.2|dip:DIP-55972N|mint:Q920B9	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:qcl0ckY0w3tIem/ezLyPtHVUnZA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8C079	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-11110029|uniprotkb:Q8CIF7|uniprotkb:Q8BZC6|uniprotkb:Q80T92|ensembl:ENSMUSP00000068587	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:strp1_mouse(display_long)|uniprotkb:Strip1(gene name)|psi-mi:Strip1(display_short)|uniprotkb:Fam40a(gene name synonym)|uniprotkb:Kiaa1761(gene name synonym)|uniprotkb:Protein FAM40A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_705791.2|ensembl:ENSMUSG00000014601(gene)|ensembl:ENSMUST00000064759(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|interpro:IPR012486(N1221-like)|interpro:IPR021819|interpro:IPR040185	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:teE9FXl/Oh3m95osnAPkCh3K9nA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q812A2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2013018|uniprotkb:Q80U09|uniprotkb:Q8BKP4|uniprotkb:Q8BLD0|uniprotkb:Q925I2	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:srgp3_mouse(display_long)|uniprotkb:Srgap3(gene name)|psi-mi:Srgap3(display_short)|uniprotkb:Arhgap14(gene name synonym)|uniprotkb:Kiaa0411(gene name synonym)|uniprotkb:Srgap2(gene name synonym)|uniprotkb:WAVE-associated Rac GTPase-activating protein(gene name synonym)|uniprotkb:Rho GTPase-activating protein 14(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR031160|refseq:NP_536696.4|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|mint:Q812A2|interpro:IPR035648|interpro:IPR036028|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0030336"(negative regulation of cell migration)|reactome:R-MMU-9013148|reactome:R-MMU-9013149	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:rfo/ZKi//Gub/088qDvqLIvgdng10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q62420	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-77971|ensembl:ENSMUSP00000030212|uniprotkb:Q3UTL7|uniprotkb:Q3UY49|uniprotkb:Q8BXS6|uniprotkb:Q8VBV1	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:sh3g2_mouse(display_long)|uniprotkb:Sh3gl2(gene name)|psi-mi:Sh3gl2(display_short)|uniprotkb:Sh3d2a(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:Een1(gene name synonym)|uniprotkb:SH3p4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR035824|interpro:IPR036028|mint:Q62420|rcsb pdb:1ZWW|reactome:R-MMU-177504|reactome:R-MMU-182971|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-437239|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0008022"(protein C-terminus binding)|ensembl:ENSMUSG00000028488(gene)|ensembl:ENSMUST00000030212(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|refseq:NP_062408.2|dip:DIP-30992N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:hAkiLVjGXejkjd5pRcuq9wVXrfk10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:G3X972	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-11079353|ensembl:ENSMUSP00000045955	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:g3x972_mouse(display_long)|uniprotkb:Sec24c(gene name)|psi-mi:Sec24c(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_766184.2|ensembl:ENSMUSG00000039367(gene)|ensembl:ENSMUST00000048657(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR007123(Gelsolin region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR041742|reactome:R-MMU-204005|reactome:R-MMU-2132295|reactome:R-MMU-5694530|reactome:R-MMU-983170	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:khjAPBQKBRzNnYP47XMkNTMX7cE10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q01405	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-775901|ensembl:ENSMUSP00000021375|uniprotkb:Q8JZL4	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:sc23a_mouse(display_long)|uniprotkb:SEC23-related protein A(gene name synonym)|uniprotkb:Sec23a(gene name)|psi-mi:Sec23a(display_short)|uniprotkb:Sec23(gene name synonym)|uniprotkb:Sec23r(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000020986(gene)|ensembl:ENSMUST00000021375(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR007123(Gelsolin region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|refseq:NP_033173.2|refseq:XP_006515691.1|dip:DIP-32032N|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR037364|interpro:IPR037550|mint:Q01405|reactome:R-MMU-204005|reactome:R-MMU-2132295|reactome:R-MMU-5694530|reactome:R-MMU-983170	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:0aSRfr1sJuL/w805EjjbO4tw/Hg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9Z315	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-6908457|ensembl:ENSMUSP00000047397|uniprotkb:Q8K155|uniprotkb:Q9R1I9|uniprotkb:Q9R270	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:snut1_mouse(display_long)|uniprotkb:Sart1(gene name)|psi-mi:Sart1(display_short)|uniprotkb:Haf(gene name synonym)|uniprotkb:Hypoxia-associated factor(gene name synonym)|uniprotkb:Squamous cell carcinoma antigen recognized by T-cells 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000039148(gene)|ensembl:ENSMUST00000044207(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000481"(maturation of 5S rRNA)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0045585"(positive regulation of cytotoxic T cell differentiation)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR005011(SART-1 protein)|mint:Q9Z315|reactome:R-MMU-72163|refseq:NP_058578.3	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:xXixsXxmATBD8YAV3KQHjXvKDzo10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8C796	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-3043949|ensembl:ENSMUSP00000063335|uniprotkb:Q9JMK4	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:rcor2_mouse(display_long)|uniprotkb:Rcor2(gene name)|psi-mi:Rcor2(display_short)|uniprotkb:M-CoREST(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000024968(gene)|ensembl:ENSMUST00000066646(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|mint:Q8C796|refseq:NP_001307483.1|refseq:NP_473389.2|dip:DIP-59754N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:R+uWIOSogm6HqGyspApSgHyMh1k10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8CFE3	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2337309|uniprotkb:Q3V092|uniprotkb:Q8BK28|uniprotkb:Q8CHI2|uniprotkb:K3W4P9|ensembl:ENSMUSP00000082034	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:rcor1_mouse(display_long)|uniprotkb:Rcor1(gene name)|psi-mi:Rcor1(display_short)|uniprotkb:D12Wsu95e(gene name synonym)|uniprotkb:Kiaa0071(gene name synonym)|uniprotkb:Protein CoREST(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:XP_006515823.1|dip:DIP-48899N|refseq:NP_932140.1|ensembl:ENSMUSG00000037896(gene)|ensembl:ENSMUST00000084968(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:1990391"(DNA repair complex)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|mint:Q8CFE3|reactome:R-MMU-3214815|reactome:R-MMU-983231	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:5yFpm82AhZnBT5toA6FfcvVKS3E10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q7TPM1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16728307|ensembl:ENSMUSP00000035734|uniprotkb:A2AN31|uniprotkb:Q8C755	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:prc2b_mouse(display_long)|uniprotkb:HLA-B-associated transcript 2-like 1(gene name synonym)|uniprotkb:Proline-rich coiled-coil protein 2B(gene name synonym)|uniprotkb:Prrc2b(gene name)|psi-mi:Prrc2b(display_short)|uniprotkb:Bat2l(gene name synonym)|uniprotkb:Bat2l1(gene name synonym)|uniprotkb:Kiaa0515(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000039262(gene)|ensembl:ENSMUST00000036691(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q7TPM1|refseq:NP_001153106.1|refseq:NP_766249.2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:WlCA3MFhuVeSWOib983JRtCgwRI10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P12367	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-645747	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kap2_mouse(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	rcsb pdb:3J4Q|rcsb pdb:3J4R|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rcsb pdb:1KMU|rcsb pdb:1KMW|rcsb pdb:1L6E|rcsb pdb:1R2A|rcsb pdb:2IZY|rcsb pdb:2QVS|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-5610787|reactome:R-MMU-983231|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:/SHXBtLe0gVa9Rf+boM1hNLRAms10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P48453	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-642618|uniprotkb:Q6NZR4|ensembl:ENSMUSP00000125722	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:pp2bb_mouse(display_long)|uniprotkb:Calmodulin-dependent calcineurin A subunit beta isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Ppp3cb(gene name)|psi-mi:Ppp3cb(display_short)|uniprotkb:Calnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_032940.1|refseq:NP_001297355.1|refseq:NP_001297356.1|ensembl:ENSMUSG00000021816(gene)|ensembl:ENSMUST00000159027(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P48453|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|go:"GO:0005516"(calmodulin binding)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:YD7q3dcL87htgwHRd5m5ReMlqd010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9R0L6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-4284371|uniprotkb:O70287|uniprotkb:Q3URH6|uniprotkb:Q7TMS7|uniprotkb:Q8C9V2|uniprotkb:Q91Y27|uniprotkb:Q91Y28|uniprotkb:Q91Y51|uniprotkb:Q9CRK8|uniprotkb:Q923L0|uniprotkb:Q9CT57|uniprotkb:E9QLK2|ensembl:ENSMUSP00000039709	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:pcm1_mouse(display_long)|uniprotkb:Pcm1(gene name)|psi-mi:Pcm1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_076151.2|refseq:XP_006509361.1|ensembl:ENSMUSG00000031592(gene)|ensembl:ENSMUST00000045218(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q9R0L6|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-380320	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:OT+ZOQY5pqQojMcLCWMIY+6zdl410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8K2T8	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-642477|uniprotkb:Q3UY97|uniprotkb:Q9CS63|uniprotkb:Q9JJ99|ensembl:ENSMUSP00000003529	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:paf1_mouse(display_long)|uniprotkb:Paf1(gene name)|psi-mi:Paf1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_062331.2|ensembl:ENSMUSG00000003437(gene)|ensembl:ENSMUST00000003529(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8K2T8|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-75955|reactome:R-MMU-8866654	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:1cFGAVgb19bf33BaPcIowpXT5qc10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9D6Z1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-527254|uniprotkb:Q3UD45|uniprotkb:Q8BVL1|uniprotkb:Q8VDT2|uniprotkb:Q99LT8|uniprotkb:Q9CT15|ensembl:ENSMUSP00000099487	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:nop56_mouse(display_long)|uniprotkb:Nop56(gene name)|psi-mi:Nop56(display_short)|uniprotkb:Nol5a(gene name synonym)|uniprotkb:Nucleolar protein 5A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_077155.2|ensembl:ENSMUSG00000027405(gene)|ensembl:ENSMUST00000103198(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|interpro:IPR012974(NOP5, N-terminal)|interpro:IPR012976(NOSIC)|interpro:IPR036070|interpro:IPR042239|mint:Q9D6Z1|reactome:R-MMU-6791226	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:5darNL7hBt/XPnvcm0hiVxx7WDY10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q5NCX5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-4284398|uniprotkb:Q3U090|uniprotkb:Q5NCX4|uniprotkb:Q69ZA2|uniprotkb:Q8R1V5|ensembl:ENSMUSP00000053235	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:neul4_mouse(display_long)|uniprotkb:Neurl4(gene name)|psi-mi:Neurl4(display_short)|uniprotkb:Kiaa1787(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001013432.1|refseq:NP_001278047.1|refseq:NP_001278048.1|ensembl:ENSMUSG00000047284(gene)|ensembl:ENSMUST00000061837(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR006573(NEUZ)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037962|interpro:IPR043136|mint:Q5NCX5|refseq:XP_017169947.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:ptQRCtQs60MpIBFD5++Vnv69Sfc10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6P5H2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2899462|ensembl:ENSMUSP00000088493|uniprotkb:A1E2I2|uniprotkb:Q80X00|uniprotkb:Q8BPH7|uniprotkb:Q9CV43|uniprotkb:Q9R0C4	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:nest_mouse(display_long)|uniprotkb:Nes(gene name)|psi-mi:Nes(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUST00000090973(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030844"(positive regulation of intermediate filament depolymerization)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048858"(cell projection morphogenesis)|ensembl:ENSMUSG00000004891(gene)|go:"GO:0072089"(stem cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR018039|interpro:IPR031211|interpro:IPR039008|refseq:NP_057910.3	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:c9UQwTSScUEP6n41WzoQiEzEyN410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9WU42	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-6673326|ensembl:ENSMUSP00000107029|uniprotkb:E9Q9V0|uniprotkb:Q9WU43|uniprotkb:Q9WUC1	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ncor2_mouse(display_long)|uniprotkb:Ncor2(gene name)|psi-mi:Ncor2(display_short)|uniprotkb:Smrt(gene name synonym)|uniprotkb:Silencing mediator of retinoic acid and thyroid hormone receptor(gene name synonym)|uniprotkb:T3 receptor-associating factor(gene name synonym)|uniprotkb:Thyroid-, retinoic-acid-receptor-associated corepressor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:Q9WU42|reactome:R-MMU-2173795|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-383280|reactome:R-MMU-400206|reactome:R-MMU-9029569|reactome:R-MMU-9623433|reactome:R-MMU-9707564|ensembl:ENSMUSG00000029478(gene)|ensembl:ENSMUST00000111398(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021537"(telencephalon development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0030900"(forebrain development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:XP_011239133.1|refseq:NP_001240833.1|refseq:NP_001240834.1|dip:DIP-42595N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:/OTDXDBeSGySNf9Sfg/BDtf8FDA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q99104	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-400199|uniprotkb:E9PUE5|ensembl:ENSMUSP00000116028	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:myo5a_mouse(display_long)|uniprotkb:Myo5a(gene name)|psi-mi:Myo5a(display_short)|uniprotkb:Dilute(gene name synonym)|uniprotkb:Dilute myosin heavy chain, non-muscle(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_034994.2|ensembl:ENSMUSG00000034593(gene)|ensembl:ENSMUST00000123128(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000149"(SNARE binding)|go:"GO:0001726"(ruffle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007601"(visual perception)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014046"(dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031585"(regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031982"(vesicle)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032433"(filopodium tip)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042476"(odontogenesis)|go:"GO:0042552"(myelination)|go:"GO:0042641"(actomyosin)|go:"GO:0042642"(actomyosin, myosin complex part)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043473"(pigmentation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0050808"(synapse organization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051643"(endoplasmic reticulum localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099089"(establishment of endoplasmic reticulum localization to postsynapse)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0099640"(axo-dendritic protein transport)|go:"GO:0150103"(reactive gliosis)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|go:"GO:0030318"(melanocyte differentiation)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR037988|mint:Q99104|rcsb pdb:2IX7|rcsb pdb:3WB8|rcsb pdb:4KP3|rcsb pdb:4ZLK|rcsb pdb:6KU0|reactome:R-MMU-2029482|interpro:IPR002710(Dilute)|go:"GO:0030141"(secretory granule)|dip:DIP-29542N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:8QtBlLL4DqB3An4CoCFVmvBEXBg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6NZR2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733957|ensembl:ENSMUSP00000043329|ensembl:ENSMUSP00000159374|uniprotkb:Q8R3V3	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:msd2_mouse(display_long)|uniprotkb:Msantd2(gene name)|psi-mi:Msantd2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000042138(gene)|ensembl:ENSMUST00000048604(transcript)|ensembl:ENSMUST00000239463(transcript)|interpro:IPR042792|interpro:IPR044822|refseq:NP_666334.2|refseq:XP_006510295.1|refseq:XP_006510296.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:dztqgdMB87sv/fxdMjLsq0ZKOXg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:A2AWL7	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-1216544|uniprotkb:Q3TS36|uniprotkb:Q6A056|uniprotkb:Q8BQX1|uniprotkb:Q8CCL4|uniprotkb:Q9QXJ5|uniprotkb:A2AWL6|ensembl:ENSMUSP00000043795	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:mgap_mouse(display_long)|uniprotkb:Mga(gene name)|psi-mi:Mga(display_short)|uniprotkb:Kiaa4252(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_038748.2|ensembl:ENSMUSG00000033943(gene)|ensembl:ENSMUST00000046717(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|reactome:R-MMU-8953750	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:KTyR7itpvWUYW8ZG1tVxQHy7ysM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8K310	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-1216295|ensembl:ENSMUSP00000125761|ensembl:ENSMUSP00000158074|ensembl:ENSMUSP00000158537	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:matr3_mouse(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_034901.2|rcsb pdb:1X4F|rcsb pdb:1X4D|ensembl:ENSMUSG00000037236(gene)|ensembl:ENSMUST00000166793(transcript)|ensembl:ENSMUST00000235199(transcript)|ensembl:ENSMUST00000237744(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:Q8K310	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:AwtFbI+oRfha+mn/v3yzG6bNXYg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P97820	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-644181	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:m4k4_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase kinase 4(gene name synonym)|uniprotkb:HPK/GCK-like kinase HGK(gene name synonym)|uniprotkb:Nck-interacting kinase(gene name synonym)|uniprotkb:Map4k4(gene name)|psi-mi:Map4k4(display_short)|uniprotkb:Nik(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001239129.1|refseq:NP_001239130.1|refseq:NP_001239131.1|refseq:NP_032722.2|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-2559580|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032014"(positive regulation of ARF protein signal transduction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-40973N|mint:P97820	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:laMTX6DrOoTz4D8zxLP5ohzqKyw10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9ER67	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16731218|ensembl:ENSMUSP00000026302|ensembl:ENSMUSP00000108317|ensembl:ENSMUSP00000108319|ensembl:ENSMUSP00000108320	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:q9er67_mouse(display_long)|uniprotkb:Maged2(gene name)|psi-mi:Maged2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000025268(gene)|ensembl:ENSMUST00000026302(transcript)|ensembl:ENSMUST00000112697(transcript)|ensembl:ENSMUST00000112699(transcript)|ensembl:ENSMUST00000112700(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007565"(female pregnancy)|go:"GO:0070294"(renal sodium ion absorption)|interpro:IPR002190(MAGE protein)|interpro:IPR028810|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-MMU-114608|refseq:NP_001186175.1|refseq:NP_109625.1|refseq:XP_006529060.1|refseq:XP_006529061.1|refseq:XP_006529062.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:+3Z5N6WLUNM2ed7Irzn9DAXL+AU10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q3UM18	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733930|ensembl:ENSMUSP00000112860|uniprotkb:Q68ED9|uniprotkb:Q80V36	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:lsg1_mouse(display_long)|uniprotkb:Lsg1(gene name)|psi-mi:Lsg1(display_short)|uniprotkb:D16Bwg1547e(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000022538(gene)|ensembl:ENSMUST00000117363(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0051168"(nuclear export)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR030378|interpro:IPR043358|mint:Q3UM18|refseq:NP_835170.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:NwGi0wFHlU6jO7ZbZzEhbBkT6oA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P14733	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-445247|uniprotkb:Q61791|ensembl:ENSMUSP00000025486	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:lmnb1_mouse(display_long)|uniprotkb:Lmnb1(gene name)|psi-mi:Lmnb1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_034851.2|mint:P14733|reactome:R-MMU-9035034|reactome:R-MMU-2559584|reactome:R-MMU-352238|reactome:R-MMU-4419969|reactome:R-MMU-9013405|ensembl:ENSMUSG00000024590(gene)|ensembl:ENSMUST00000025486(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:1904609"(cellular response to monosodium L-glutamate)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|go:"GO:0003690"(double-stranded DNA binding)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:/Mo4KS6v6KhDRlYgD5CVVVtWVD810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:B7ZNG0	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16356783|uniprotkb:B2RUB1	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kif7_mouse(display_long)|uniprotkb:Kif7(gene name)|psi-mi:Kif7(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0003279"(cardiac septum development)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0035904"(aorta development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|go:"GO:0036064"(ciliary basal body)|reactome:R-MMU-5610787|reactome:R-MMU-5632684|dip:DIP-61761N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:WZ5rB98fyn0jmOSroekMVmjUZMM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P28738	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2506834|uniprotkb:Q6NXI9|ensembl:ENSMUSP00000028102|uniprotkb:Q9Z2F8	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kif5c_mouse(display_long)|uniprotkb:Kif5c(gene name)|psi-mi:Kif5c(display_short)|uniprotkb:Nkhc2(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000026764(gene)|ensembl:ENSMUST00000028102(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051028"(mRNA transport)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098964"(anterograde dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0150034"(distal axon)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:P28738|rcsb pdb:1VFV|rcsb pdb:1VFW|rcsb pdb:1VFX|rcsb pdb:1VFZ|rcsb pdb:3J6H|rcsb pdb:3WRD|rcsb pdb:3X2T|rcsb pdb:5HLE|refseq:NP_032475.2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:GbPyKDztqPG8BP2+44k3TXPuI/010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q61768	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-776129|uniprotkb:Q5BL10|uniprotkb:O08711|uniprotkb:Q61580|ensembl:ENSMUSP00000025083	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kinh_mouse(display_long)|uniprotkb:Ubiquitous kinesin heavy chain(gene name synonym)|uniprotkb:Conventional kinesin heavy chain(gene name synonym)|uniprotkb:Kif5b(gene name)|psi-mi:Kif5b(display_short)|uniprotkb:Khcs(gene name synonym)|uniprotkb:Kns1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_032474.2|dip:DIP-32053N|ensembl:ENSMUSG00000006740(gene)|ensembl:ENSMUST00000025083(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0021766"(hippocampus development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032418"(lysosome localization)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072383"(plus-end-directed vesicle transport along microtubule)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099609"(microtubule lateral binding)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905152"(positive regulation of voltage-gated sodium channel activity)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q61768|rcsb pdb:6IGN|rcsb pdb:6IGV|reactome:R-MMU-2132295|reactome:R-MMU-5625970|reactome:R-MMU-6811434|reactome:R-MMU-983189	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:11aePhwWZOqqAabjyanVgdHQQso10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P33175	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-349710|uniprotkb:Q5DTP1|uniprotkb:Q6PDY7|uniprotkb:Q9Z2F9|ensembl:ENSMUSP00000096775|ensembl:ENSMUSP00000151402	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kif5a_mouse(display_long)|uniprotkb:Kif5a(gene name)|psi-mi:Kif5a(display_short)|uniprotkb:Kiaa4086(gene name synonym)|uniprotkb:Kif5(gene name synonym)|uniprotkb:Neuronal kinesin heavy chain(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 1(gene name synonym)|uniprotkb:Nkhc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001034089.1|refseq:NP_032473.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P33175|reactome:R-MMU-2132295|reactome:R-MMU-5625970|reactome:R-MMU-6811434|reactome:R-MMU-983189|ensembl:ENSMUSG00000074657(gene)|ensembl:ENSMUST00000099172(transcript)|ensembl:ENSMUST00000217895(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:otK0LxjRwOuSLqL6iOEI+7BY+SI10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6ZQ88	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-1216284|ensembl:ENSMUSP00000111977|uniprotkb:Q6PB53|uniprotkb:Q8VEA1|uniprotkb:A3KG94	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kdm1a_mouse(display_long)|uniprotkb:Kdm1a(gene name)|psi-mi:Kdm1a(display_short)|uniprotkb:Kiaa0601(gene name synonym)|uniprotkb:Lsd1(gene name synonym)|uniprotkb:Flavin-containing amine oxidase domain-containing protein 2(gene name synonym)|uniprotkb:BRAF35-HDAC complex protein BHC110(gene name synonym)|uniprotkb:Aof2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_598633.2|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032451"(demethylase activity)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032453"(histone H3-methyl-lysine-4 demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0032991"(protein-containing complex)|ensembl:ENSMUSG00000036940(gene)|ensembl:ENSMUST00000116273(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0008134"(transcription factor binding)|dip:DIP-38599N|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0033184"(positive regulation of histone ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034648"("obsolete histone demethylase activity (H3-dimethyl-K4 specific)")|go:"GO:0034649"("obsolete histone demethylase activity (H3-monomethyl-K4 specific)")|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0043426"(MRF binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046098"(guanine metabolic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0055001"(muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061752"(telomeric repeat-containing RNA binding)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1903827"|go:"GO:1990138"(neuron projection extension)|go:"GO:1990391"(DNA repair complex)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR002937(Amine oxidase)|interpro:IPR007526(SWIRM)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017366(Histone lysine-specific demethylase)|interpro:IPR036188|mint:Q6ZQ88|reactome:R-MMU-3214815|reactome:R-MMU-3214842|reactome:R-MMU-5625886|reactome:R-MMU-9018519|reactome:R-MMU-983231|interpro:IPR036388	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:4rlXgUzLs3mhV2FLX207Io9etU010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q80UN1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733904|ensembl:ENSMUSP00000077200|uniprotkb:Q3TLH9|uniprotkb:Q3TY35	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kctd9_mouse(display_long)|uniprotkb:Kctd9(gene name)|psi-mi:Kctd9(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000034327(gene)|ensembl:ENSMUST00000078053(transcript)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR021789|interpro:IPR036572|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|refseq:NP_001104498.1|refseq:NP_001272862.1|refseq:NP_598834.2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:zwHzxq5nhcFQdJoq1Y1yNuw97vE10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q99JP6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-6272061|ensembl:ENSMUSP00000117033|uniprotkb:D3Z6N9|uniprotkb:Q9Z215	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:home3_mouse(display_long)|uniprotkb:Homer3(gene name)|psi-mi:Homer3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000003573(gene)|ensembl:ENSMUST00000140212(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q99JP6|reactome:R-MMU-6794361|refseq:NP_001139625.1|refseq:NP_036114.2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:7IOPI8VTi6aKK/I0tl4AiUUIXIU10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q61666	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2657552|uniprotkb:O08845|uniprotkb:Q3TFY0|uniprotkb:Q3UX35|uniprotkb:Q62365|uniprotkb:Q7TMW4|ensembl:ENSMUSP00000004222	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:hira_mouse(display_long)|uniprotkb:Hira(gene name)|psi-mi:Hira(display_short)|uniprotkb:Tuple1(gene name synonym)|uniprotkb:TUP1-like enhancer of split protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_034565.2|ensembl:ENSMUSG00000022702(gene)|ensembl:ENSMUST00000004222(transcript)|go:"GO:0000417"(HIR complex)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007369"(gastrulation)|go:"GO:0016605"(PML body)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR011494(TUP1-like enhancer of split)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031120|interpro:IPR036322|mint:Q61666|reactome:R-MMU-2559584	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:EhPH7DlphMVQhvIhJUtXRA1m+Fg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q4U2R1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P70288	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-302251|uniprotkb:B2RRP3	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:hdac2_mouse(display_long)|uniprotkb:Hdac2(gene name)|psi-mi:Hdac2(display_short)|uniprotkb:Yy1bp(gene name synonym)|uniprotkb:YY1 transcription factor-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-4551638|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-9022692|reactome:R-MMU-983231|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|refseq:NP_032255.2|dip:DIP-32854N|mint:P70288	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:bGLIDKTlyhBz40NViC8calRacZ010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q99ME9	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-4285566|uniprotkb:Q99K16|uniprotkb:Q99P78|uniprotkb:Q9CT02|ensembl:ENSMUSP00000152412	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:gtpb4_mouse(display_long)|uniprotkb:Gtpbp4(gene name)|psi-mi:Gtpbp4(display_short)|uniprotkb:Crfg(gene name synonym)|uniprotkb:Nog1(gene name synonym)|uniprotkb:Chronic renal failure gene protein(gene name synonym)|uniprotkb:GTP-binding protein NGB(gene name synonym)|uniprotkb:Nucleolar GTP-binding protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_081276.2|ensembl:ENSMUSG00000021149(gene)|ensembl:ENSMUST00000222098(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033342"(negative regulation of collagen binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR010674(Nucleolar GTP-binding 1)|interpro:IPR012973(NOG, C-terminal)|interpro:IPR024926|interpro:IPR027417|interpro:IPR031167|interpro:IPR041623|mint:Q99ME9	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:bcJx83SRfrtIzUbasVwCDleHiR010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9WV60	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-400793|ensembl:ENSMUSP00000023507	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:gsk3b_mouse(display_long)|uniprotkb:Gsk3b(gene name)|psi-mi:Gsk3b(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_062801.1|dip:DIP-32446N|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006983"(ER overload response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014043"(negative regulation of neuron maturation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034452"(dynactin binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:Q9WV60|rcsb pdb:4NU1|rcsb pdb:5AIR|rcsb pdb:6AE3|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3371453|reactome:R-MMU-399956|reactome:R-MMU-4641262|reactome:R-MMU-5250924|reactome:R-MMU-5610785|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046849"(bone remodeling)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0106027"(neuron projection organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904780"(negative regulation of protein localization to centrosome)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|ensembl:ENSMUSG00000022812(gene)|ensembl:ENSMUST00000023507(transcript)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:FKe0WkOBBYU0vIJLmcFNMJ+KVHA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8VHR5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-3043880|ensembl:ENSMUSP00000041370|ensembl:ENSMUSP00000142514|ensembl:ENSMUSP00000142617|uniprotkb:Q8C9Q3	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:p66b_mouse(display_long)|uniprotkb:Gatad2b(gene name)|psi-mi:Gatad2b(display_short)|uniprotkb:GATA zinc finger domain-containing protein 2B(gene name synonym)|uniprotkb:p66/p68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000042390(gene)|ensembl:ENSMUST00000049382(transcript)|ensembl:ENSMUST00000199607(transcript)|ensembl:ENSMUST00000199754(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016581"(NuRD complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR032346|interpro:IPR040386|reactome:R-MMU-3214815|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|mint:Q8VHR5|refseq:XP_006501422.2|refseq:NP_647465.1|refseq:XP_006501424.1|dip:DIP-62049N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:u6tGN+nqNC/bn1hYG7e1f3XGgj010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P97855	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-6666067|ensembl:ENSMUSP00000018727	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:g3bp1_mouse(display_long)|uniprotkb:G3bp1(gene name)|psi-mi:G3bp1(display_short)|uniprotkb:G3bp(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym)|uniprotkb:HDH-VIII(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000018583(gene)|ensembl:ENSMUST00000018727(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:P97855|refseq:NP_038744.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:Xxq1G7S8hxbGPvterifIOxpri6U10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P58463	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733850|ensembl:ENSMUSP00000031545|ensembl:ENSMUSP00000111137|uniprotkb:Q6PD37|uniprotkb:Q8C4F0|uniprotkb:Q8R441	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:foxp2_mouse(display_long)|uniprotkb:Foxp2(gene name)|psi-mi:Foxp2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000029563(gene)|ensembl:ENSMUST00000031545(transcript)|ensembl:ENSMUST00000115477(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021757"(caudate nucleus development)|go:"GO:0021758"(putamen development)|go:"GO:0030324"(lung development)|go:"GO:0042297"(vocal learning)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060013"(righting reflex)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|go:"GO:0042802"(identical protein binding)|refseq:NP_001273536.1|refseq:NP_444472.2|refseq:NP_997600.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:aWO45utqtgo/PNqVhTI/ZWx7Xxg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8K3B1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16731078|ensembl:ENSMUSP00000040168|uniprotkb:Q5M7B1	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:fbsp1_mouse(display_long)|uniprotkb:F-box only protein 45(gene name synonym)|uniprotkb:Fbxo45(gene name)|psi-mi:Fbxo45(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000035764(gene)|ensembl:ENSMUST00000042732(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0021960"(anterior commissure morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060384"(innervation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035784|interpro:IPR036047|interpro:IPR043136|go:"GO:0060386"(synapse assembly involved in innervation)|go:"GO:0098793"(presynapse)|refseq:NP_775615.2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:7NVV04mOJfx6uy7iXOeocaEx3yo10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q61545	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-1606991|uniprotkb:Q9D2P0|ensembl:ENSMUSP00000078867	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ews_mouse(display_long)|uniprotkb:Ewsr1(gene name)|psi-mi:Ewsr1(display_short)|uniprotkb:Ews(gene name synonym)|uniprotkb:Ewsh(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_031994.2|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033109|interpro:IPR034869|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:Q61545|ensembl:ENSMUSG00000009079(gene)|ensembl:ENSMUST00000079949(transcript)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:bvajg+ZT71/K+6hwdHFdOewgvrw10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9Z148	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-444966|uniprotkb:Q6PE08|uniprotkb:Q8K4R6|uniprotkb:Q8K4R7|uniprotkb:Q9Z149|uniprotkb:A2CG75|ensembl:ENSMUSP00000013931	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ehmt2_mouse(display_long)|uniprotkb:Histone H3-K9 methyltransferase 3(gene name synonym)|uniprotkb:Euchromatic histone-lysine N-methyltransferase 2(gene name synonym)|uniprotkb:HLA-B-associated transcript 8(gene name synonym)|uniprotkb:Protein G9a(gene name synonym)|uniprotkb:Ehmt2(gene name)|psi-mi:Ehmt2(display_short)|uniprotkb:G9a(gene name synonym)|uniprotkb:Ng36(gene name synonym)|uniprotkb:Bat8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_665829.1|refseq:NP_671493.1|refseq:NP_001273502.1|refseq:NP_001273504.1|ensembl:ENSMUSG00000013787(gene)|ensembl:ENSMUST00000013931(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007281"(germ cell development)|go:"GO:0007286"(spermatid development)|go:"GO:0007616"(long-term memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009566"(fertilization)|go:"GO:0010424"(DNA methylation on cytosine within a CG sequence)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035265"(organ growth)|go:"GO:0035690"|go:"GO:0036166"(phenotypic switching)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048665"(neuron fate specification)|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0060992"(response to fungicide)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR002110(Ankyrin)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR020683|interpro:IPR036770|interpro:IPR038034|interpro:IPR043550|mint:Q9Z148|reactome:R-MMU-2559582|reactome:R-MMU-3214841|reactome:R-MMU-6804760|reactome:R-MMU-73762|reactome:R-MMU-8953750|dip:DIP-31916N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:SN94zTs0cmZHuzgtVLjSTDtfOAM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q5DW34	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-1216557|uniprotkb:A2AIS3|uniprotkb:A2AIS4|uniprotkb:Q6PGM0|uniprotkb:Q5EBR1|ensembl:ENSMUSP00000119057	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ehmt1_mouse(display_long)|uniprotkb:Ehmt1(gene name)|psi-mi:Ehmt1(display_short)|uniprotkb:Euhmtase1(gene name synonym)|uniprotkb:Glp(gene name synonym)|uniprotkb:Kmt1d(gene name synonym)|uniprotkb:Euchromatic histone-lysine N-methyltransferase 1(gene name synonym)|uniprotkb:G9a-like protein 1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1D(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001012536.2|refseq:NP_001103156.1|refseq:NP_001103157.1|dip:DIP-49000N|dip:DIP-59572N|ensembl:ENSMUSG00000036893(gene)|ensembl:ENSMUST00000147147(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018026"(peptidyl-lysine monomethylation)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0060992"(response to fungicide)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR001214(SET)|interpro:IPR002110(Ankyrin)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR020683|interpro:IPR036770|interpro:IPR038035|interpro:IPR043550|reactome:R-MMU-2559582|reactome:R-MMU-3214841|reactome:R-MMU-6804760|reactome:R-MMU-8953750|mint:Q5DW34	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	caution:This sequence has been withdrawn from Uniprot.	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:hUGLAr8PFLD6Tzs7WbDQJs//I1k10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:O08810	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2550333|ensembl:ENSMUSP00000102675	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:u5s1_mouse(display_long)|uniprotkb:Eftud2(gene name)|psi-mi:Eftud2(display_short)|uniprotkb:Snrp116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000020929(gene)|ensembl:ENSMUST00000107060(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:O08810|reactome:R-MMU-72163|reactome:R-MMU-72165|refseq:NP_001103465.1|refseq:NP_035561.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:BXx/oB92nIw8mcrZHvpWc+E+DFA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q7TNL5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733678|ensembl:ENSMUSP00000156500	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:q7tnl5_mouse(display_long)|uniprotkb:Ppp2r5d(gene name)|psi-mi:Ppp2r5d(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000059409(gene)|ensembl:ENSMUST00000233988(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072542"(protein phosphatase activator activity)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-9648025|reactome:R-MMU-4641262|refseq:XP_006524092.2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:rCw/DQB0WrRvsCUMGxrrGzUW89I10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q3UJB9	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2553526|uniprotkb:Q3U6U8|uniprotkb:Q8R223|uniprotkb:Q7TS78	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:edc4_mouse(display_long)|uniprotkb:Edc4(gene name)|psi-mi:Edc4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|reactome:R-MMU-430039|refseq:NP_001288029.1|interpro:IPR032401|refseq:NP_853625.1|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q3UJB9	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:FVX5K/2axUrzI66j1QPmJsqpxec10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9JHU4	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-645061|uniprotkb:E9QM71|ensembl:ENSMUSP00000018851	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dyhc1_mouse(display_long)|uniprotkb:Dhc1(gene name synonym)|uniprotkb:Dyhc(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:Dync1h1(gene name)|psi-mi:Dync1h1(display_short)|uniprotkb:Dnch1(gene name synonym)|uniprotkb:Dnchc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_084514.2|ensembl:ENSMUSG00000018707(gene)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002177"(manchette)|go:"GO:0003341"(cilium movement)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|ensembl:ENSMUST00000018851(transcript)|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|interpro:IPR042219|mint:Q9JHU4|rcsb pdb:3ERR|rcsb pdb:3J1T|rcsb pdb:3J1U|rcsb pdb:3WUQ|rcsb pdb:5AYH|rcsb pdb:6RZA|rcsb pdb:6RZB|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:sbED0xqQpe32T7I8ijeS3Xqlx7010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8R1A4	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-776274|uniprotkb:Q45V78|uniprotkb:Q5PRE6|uniprotkb:Q6PJ17|uniprotkb:Q9CSB6|uniprotkb:Q9CXM7	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dock7_mouse(display_long)|uniprotkb:Gm430(gene name synonym)|uniprotkb:Dock7(gene name)|psi-mi:Dock7(display_short)|uniprotkb:Kiaa1771(gene name synonym)|uniprotkb:Mnlt(gene name synonym)|uniprotkb:Protein moonlight(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR027357|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR043162|interpro:IPR043161|interpro:IPR026791|interpro:IPR027007|interpro:IPR035892|interpro:IPR037808|mint:Q8R1A4|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043473"(pigmentation)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|reactome:R-MMU-8875555|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-983231	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:T4W30iJF8XaTuK57c9vlJFr9gpg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:A2AF47	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733818|ensembl:ENSMUSP00000033419|uniprotkb:Q5KTP7	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:doc11_mouse(display_long)|uniprotkb:Activated Cdc42-associated guanine nucleotide exchange factor(gene name synonym)|uniprotkb:Zizimin-2(gene name synonym)|uniprotkb:Dock11(gene name)|psi-mi:Dock11(display_short)|uniprotkb:Ziz2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000031093(gene)|ensembl:ENSMUST00000033419(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037809|interpro:IPR043161|interpro:IPR043162|mint:A2AF47|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-983231|refseq:NP_001009947.2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:Hj/RFYqY5pvpk7vrJ1VKTZ0K0e010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q62167	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-773173|uniprotkb:O09060|uniprotkb:O09143|ensembl:ENSMUSP00000000804	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ddx3x_mouse(display_long)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD3(gene name synonym)|uniprotkb:Embryonic RNA helicase(gene name synonym)|uniprotkb:D1Pas1-related sequence 2(gene name synonym)|uniprotkb:Ddx3x(gene name)|psi-mi:Ddx3x(display_short)|uniprotkb:D1Pas1-rs2(gene name synonym)|uniprotkb:Ddx3(gene name synonym)|uniprotkb:Dead3(gene name synonym)|uniprotkb:Erh(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_034158.1|ensembl:ENSMUSG00000000787(gene)|ensembl:ENSMUST00000000804(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q62167|reactome:R-MMU-6798695	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:K7PtRsPpXHni4TU8uzOsr6QaVxA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:O88809	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16724620|ensembl:ENSMUSP00000033642|ensembl:ENSMUSP00000084570|uniprotkb:Q6E5A4	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dcx_mouse(display_long)|uniprotkb:Doublin(gene name synonym)|uniprotkb:Lissencephalin-X(gene name synonym)|uniprotkb:Dcx(gene name)|psi-mi:Dcx(display_short)|uniprotkb:Dcn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000031285(gene)|ensembl:ENSMUST00000033642(transcript)|ensembl:ENSMUST00000087313(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0035082"(axoneme assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060041"(retina development in camera-type eye)|interpro:IPR003533(Doublecortin)|interpro:IPR017302(Neuronal migration protein doublecortin)|interpro:IPR036572|interpro:IPR040163|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|refseq:NP_001103692.1|refseq:NP_001103693.1|refseq:NP_001103694.1|refseq:NP_034155.2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:bZVdhkO518ZmQJpBRfIqaTPon1Y10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:E9PVD3	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733775|ensembl:ENSMUSP00000077574	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:pcd16_mouse(display_long)|uniprotkb:Protein Dchs1(gene name synonym)|uniprotkb:Protein dachsous homolog 1(gene name synonym)|uniprotkb:Dchs1(gene name)|psi-mi:Dchs1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000036862(gene)|ensembl:ENSMUST00000078482(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001822"(kidney development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR039808|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007389"(pattern specification process)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0021915"(neural tube development)|go:"GO:0022008"(neurogenesis)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035329"(hippo signaling)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0048565"(digestive tract development)|go:"GO:0072006"(nephron development)|go:"GO:0072137"(condensed mesenchymal cell proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090102"(cochlea development)|go:"GO:0098609"(cell-cell adhesion)|refseq:NP_001156415.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:IvL9qSTu04flmcjH6oHTG4xRrqg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P56546	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-1384883|uniprotkb:O54855|uniprotkb:O88462|ensembl:ENSMUSP00000033269	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ctbp2_mouse(display_long)|uniprotkb:Ctbp2(gene name)|psi-mi:Ctbp2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001164215.1|refseq:NP_034110.1|refseq:XP_006507371.1|refseq:XP_006507372.1|refseq:XP_006507373.1|refseq:XP_006507374.1|refseq:XP_006507375.1|ensembl:ENSMUSG00000030970(gene)|ensembl:ENSMUST00000033269(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048386"(positive regulation of retinoic acid receptor signaling pathway)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051287"(NAD binding)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029753|interpro:IPR036291|interpro:IPR043322|mint:P56546|reactome:R-MMU-4641265	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:3fTZKboxkpsDFUB+Kh0AMeIQNYI10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:O88712	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-604547|ensembl:ENSMUSP00000078682|uniprotkb:Q3TAT1|uniprotkb:Q3TDL5|uniprotkb:Q3TUM5|uniprotkb:Q91WI6|uniprotkb:Q91YX3|uniprotkb:Q9QYG2	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ctbp1_mouse(display_long)|uniprotkb:Ctbp1(gene name)|psi-mi:Ctbp1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0017053"(transcription repressor complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051287"(NAD binding)|go:"GO:0051726"(regulation of cell cycle)|ensembl:ENSMUSG00000037373(gene)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0098793"(presynapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099526"(presynapse to nucleus signaling pathway)|ensembl:ENSMUST00000079746(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029752|go:"GO:0003682"(chromatin binding)|interpro:IPR029753|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR036291|go:"GO:0005737"(cytoplasm)|interpro:IPR043322|go:"GO:0006342"|mint:O88712|reactome:R-MMU-3769402|reactome:R-MMU-3899300|reactome:R-MMU-4641265|go:"GO:0008134"(transcription factor binding)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|refseq:NP_001185788.1|refseq:NP_001185789.1|refseq:NP_001185790.1|refseq:NP_038530.1|refseq:NP_001297464.1|dip:DIP-33907N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:l2rq9ypazCscM/WbocEKgQZcEBo10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q09XV5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-1169080|uniprotkb:Q3TV89|uniprotkb:Q5I1Z2|uniprotkb:Q6ZPM8|ensembl:ENSMUSP00000087184|ensembl:ENSMUSP00000142890	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:chd8_mouse(display_long)|uniprotkb:Chd8(gene name)|psi-mi:Chd8(display_short)|uniprotkb:Kiaa1564(gene name synonym)|uniprotkb:ATP-dependent helicase CHD8(gene name synonym)|uniprotkb:Axis duplication inhibitor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_963999.2|refseq:XP_006519539.1|ensembl:ENSMUSG00000053754(gene)|ensembl:ENSMUST00000089752(transcript)|ensembl:ENSMUST00000200169(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035176"(social behavior)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048565"(digestive tract development)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070615"|go:"GO:0071339"(MLL1 complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023780|interpro:IPR027417|interpro:IPR034724|interpro:IPR037259|interpro:IPR038718|mint:Q09XV5|reactome:R-MMU-3769402	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:ZttrOvHiz/PMCKm+pScx4Tn1Af410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q155P7	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2211248	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:q155p7_mouse(display_long)|uniprotkb:Cenpf(gene name)|psi-mi:Cenpf(display_short)|uniprotkb:Lek1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR019513|interpro:IPR018463|interpro:IPR018302|interpro:IPR043513|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001822"(kidney development)|go:"GO:0002724"(regulation of T cell cytokine production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007507"(heart development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030496"(midbody)|go:"GO:0030885"(regulation of myeloid dendritic cell activation)|go:"GO:0032386"(regulation of intracellular transport)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045120"(pronucleus)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048866"(stem cell fate specification)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0055037"(recycling endosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097539"(ciliary transition fiber)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:b3rPf5eE6WotbUeJcEwHdYF9Gwg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8JZM7	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-1216399|ensembl:ENSMUSP00000018337	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cdc73_mouse(display_long)|uniprotkb:Cdc73(gene name)|psi-mi:Cdc73(display_short)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_666103.1|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q8JZM7|reactome:R-MMU-112382|reactome:R-MMU-201722|reactome:R-MMU-5632684|reactome:R-MMU-674695|reactome:R-MMU-75955|reactome:R-MMU-8866654|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|ensembl:ENSMUSG00000026361(gene)|ensembl:ENSMUST00000018337(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:nuJ2kK0petj8iBr17I2BQzxcVmE10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6A068	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2552123|ensembl:ENSMUSP00000024727|uniprotkb:Q8K1J9	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cdc5l_mouse(display_long)|uniprotkb:Cdc5l(gene name)|psi-mi:Cdc5l(display_short)|uniprotkb:Kiaa0432(gene name synonym)|uniprotkb:Cdc5-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000023932(gene)|ensembl:ENSMUST00000024727(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|refseq:NP_690023.1|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904568"(cellular response to wortmannin)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017930|interpro:IPR021786|mint:Q6A068|reactome:R-MMU-72163|go:"GO:0005737"(cytoplasm)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:ehcu1kQlVD4/J1K3a77EcsjqRbI10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8VDP4	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2931660|ensembl:ENSMUSP00000036924|uniprotkb:Q6PIB1|uniprotkb:Q8BWR5|uniprotkb:Q8C0F0|uniprotkb:Q8R3G6	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ccar2_mouse(display_long)|uniprotkb:Ccar2(gene name)|psi-mi:Ccar2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000033712(gene)|ensembl:ENSMUST00000035612(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|interpro:IPR028811|mint:Q8VDP4|reactome:R-MMU-3371453|refseq:NP_666167.3|refseq:XP_006518959.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:4KqmxaC2o3+yWOF9dwQ9kQ7AMqs10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9WVG6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-4414343|uniprotkb:Q3TYB9|uniprotkb:Q8K1Y5|uniprotkb:Q91W24|uniprotkb:Q99KX8|ensembl:ENSMUSP00000034703	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:carm1_mouse(display_long)|uniprotkb:Carm1(gene name)|psi-mi:Carm1(display_short)|uniprotkb:Prmt4(gene name synonym)|uniprotkb:Coactivator-associated arginine methyltransferase 1(gene name synonym)|uniprotkb:Protein arginine N-methyltransferase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_067506.2|refseq:NP_694781.1|dip:DIP-44593N|ensembl:ENSMUSG00000032185(gene)|ensembl:ENSMUST00000034703(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006479"(protein methylation)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034969"(histone arginine methylation)|go:"GO:0034970"(histone H3-R2 methylation)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902415"(regulation of mRNA binding)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020989|interpro:IPR025799|interpro:IPR029063|mint:Q9WVG6|rcsb pdb:2V74|rcsb pdb:2V7E|rcsb pdb:5IH3|rcsb pdb:5IS6|rcsb pdb:5IS7|rcsb pdb:5IS8|rcsb pdb:5IS9|rcsb pdb:5ISA|rcsb pdb:5ISB|rcsb pdb:5ISC|rcsb pdb:5ISD|rcsb pdb:5ISE|rcsb pdb:5ISF|rcsb pdb:5ISG|rcsb pdb:5ISH|rcsb pdb:5ISI|rcsb pdb:5K8V|rcsb pdb:5K8W|rcsb pdb:5K8X|rcsb pdb:5LGP|rcsb pdb:5LGQ|rcsb pdb:5LGR|rcsb pdb:5LGS|rcsb pdb:5LKJ|rcsb pdb:5LV2|rcsb pdb:5LV3|rcsb pdb:5NTC|rcsb pdb:5TBH|rcsb pdb:5TBI|rcsb pdb:5TBJ|reactome:R-MMU-3214858|reactome:R-MMU-400206|reactome:R-MMU-9018519|reactome:R-MMU-9707564|go:"GO:0035642"("histone methyltransferase activity (H3-R17 specific)")	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:OhPIJ/O/PCm8s8oJoebgdYV133s10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q60865	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-647767|uniprotkb:Q6IMN3|uniprotkb:Q7TT26|uniprotkb:Q60758|uniprotkb:Q61620|ensembl:ENSMUSP00000028607|ensembl:ENSMUSP00000106777	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:capr1_mouse(display_long)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:Caprin1(gene name)|psi-mi:Caprin1(display_short)|uniprotkb:Gpiap(gene name synonym)|uniprotkb:Gpiap1(gene name synonym)|uniprotkb:Gpip137(gene name synonym)|uniprotkb:M11s1(gene name synonym)|uniprotkb:G5E5(orf name)|uniprotkb:Rng105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001104759.1|refseq:NP_001104760.1|refseq:NP_001104761.1|refseq:NP_001104762.1|refseq:NP_058019.2|ensembl:ENSMUSG00000027184(gene)|ensembl:ENSMUST00000028607(transcript)|ensembl:ENSMUST00000111147(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q60865	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:e+Dcb+82jx+CoLhlGBbdSG62dPU10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:B2RQC6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-3043834|ensembl:ENSMUSP00000013773|uniprotkb:B7ZN27	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:pyr1_mouse(display_long)|uniprotkb:Cad(gene name)|psi-mi:Cad(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000013629(gene)|ensembl:ENSMUST00000013773(transcript)|go:"GO:0002134"(UTP binding)|go:"GO:0004070"(aspartate carbamoyltransferase activity)|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004151"(dihydroorotase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014075"(response to amine)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016597"(amino acid binding)|go:"GO:0017144"|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0001889"(liver development)|go:"GO:0031000"(response to caffeine)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044205"('de novo' UMP biosynthetic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051414"(response to cortisol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR002082(Aspartate carbamoyltransferase, eukaryotic)|interpro:IPR002195(Dihydroorotase, conserved site)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|go:"GO:0019899"(enzyme binding)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR032466|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036901|interpro:IPR036914|mint:B2RQC6|reactome:R-MMU-500753|refseq:NP_076014.1|refseq:NP_001276451.1|dip:DIP-61412N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:t+qQw7me78vEm/Y4VBBhS8fmCsY10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:G3X8Q1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-5738141|ensembl:ENSMUSP00000001712	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:g3x8q1_mouse(display_long)|uniprotkb:Cabin1(gene name)|psi-mi:Cabin1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_766137.2|ensembl:ENSMUST00000001712(transcript)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015134(MEF2 binding)|interpro:IPR019734|interpro:IPR033053|reactome:R-MMU-2559584|ensembl:ENSMUSG00000020196(gene)|refseq:XP_006513082.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:XuI91C0vKCZUJwYVRyFwK6qx8ho10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:O88665	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q99PV8	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-11293861|uniprotkb:Q8C2I1|uniprotkb:Q99PV6|uniprotkb:Q99PV7|uniprotkb:Q9JLF8|ensembl:ENSMUSP00000068258	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:bc11b_mouse(display_long)|uniprotkb:Bcl11b(gene name)|psi-mi:Bcl11b(display_short)|uniprotkb:Ctip2(gene name synonym)|uniprotkb:Rit1(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 11B(gene name synonym)|uniprotkb:COUP-TF-interacting protein 2(gene name synonym)|uniprotkb:Radiation-induced tumor suppressor gene 1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001073352.1|refseq:NP_001273272.1|refseq:NP_067374.2|ensembl:ENSMUSG00000048251(gene)|ensembl:ENSMUST00000066060(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035701"(hematopoietic stem cell migration)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043368"(positive T cell selection)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043588"(skin development)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0071678"(olfactory bulb axon guidance)|go:"GO:0097535"(lymphoid lineage cell migration into thymus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:fcgBt1xNJI9kSOgCa+J7pNo5FNA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6DFV3	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16727982|uniprotkb:A2AL67|uniprotkb:Q80TD7|uniprotkb:Q80XS1	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:rhg21_mouse(display_long)|uniprotkb:Rho GTPase-activating protein 10(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 21(gene name synonym)|uniprotkb:Arhgap21(gene name)|psi-mi:Arhgap21(display_short)|uniprotkb:Arhgap10(gene name synonym)|uniprotkb:Kiaa1424(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR041489|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0051645"(Golgi localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0072384"(organelle transport along microtubule)|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-9696264|refseq:NP_001074833.3|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000198(RhoGAP)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:cfHEMUK7sE6c++73unq5fpTL6Y810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:A2ASQ1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16732264|ensembl:ENSMUSP00000101200|uniprotkb:A2ASP9|uniprotkb:A2ASQ0|uniprotkb:B2RWU1	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:agrin_mouse(display_long)|uniprotkb:Agrn(gene name)|psi-mi:Agrn(display_short)|uniprotkb:Agrin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0036122"(BMP binding)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1903277"(negative regulation of sodium ion export across plasma membrane)|go:"GO:1903407"("negative regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:2000541"(positive regulation of protein geranylgeranylation)|interpro:IPR000082(SEA)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036058|interpro:IPR036364|rcsb pdb:3PVE|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-3000178|reactome:R-MMU-975634|ensembl:ENSMUSG00000041936(gene)|ensembl:ENSMUST00000105575(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0032092"(positive regulation of protein binding)|refseq:XP_011248479.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:WJbobvxSWRhlor2OTMPSJ818FCM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P61164	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-774242|uniprotkb:P42024|uniprotkb:Q3TJF9|ensembl:ENSMUSP00000039844	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:actz_mouse(display_long)|uniprotkb:Centrosome-associated actin homolog(gene name synonym)|uniprotkb:Actin-RPV(gene name synonym)|uniprotkb:ARP1(gene name synonym)|uniprotkb:Actr1a(gene name)|psi-mi:Actr1a(display_short)|uniprotkb:Ctrn1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_058556.1|ensembl:ENSMUSG00000025228(gene)|ensembl:ENSMUST00000040270(transcript)|go:"GO:0002177"(manchette)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0043209"(myelin sheath)|go:"GO:0099738"(cell cortex region)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P61164|reactome:R-MMU-2132295|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-8854518	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:aJHKOSj1qmZ7Pk8aZAyWWd8DEdw10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q4KUS2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-775397|uniprotkb:E9QKH9|uniprotkb:Q3UHG2|ensembl:ENSMUSP00000030170	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:un13a_mouse(display_long)|uniprotkb:Munc13-1(gene name synonym)|uniprotkb:Unc13a(gene name)|psi-mi:Unc13a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001025044.2|ensembl:ENSMUSG00000034799(gene)|ensembl:ENSMUST00000030170(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030507"(spectrin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0061789"(dense core granule priming)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099011"(neuronal dense core vesicle exocytosis)|go:"GO:0099525"(presynaptic dense core vesicle exocytosis)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR010439(Protein of unknown function DUF1041)|interpro:IPR014770(Munc13 homology 1)|interpro:IPR014772(Munc13 homology 2)|interpro:IPR019558|interpro:IPR027080|interpro:IPR027082|interpro:IPR035892|interpro:IPR037302	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:B5Qv8BCg48XDED/99G5RS7g5Fn410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P39447	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-79508|uniprotkb:E9QK00|ensembl:ENSMUSP00000099652	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:zo1_mouse(display_long)|uniprotkb:Tjp1(gene name)|psi-mi:Tjp1(display_short)|uniprotkb:Zo1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005516"(calmodulin binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0005634"(nucleus)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0005737"(cytoplasm)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0005921"(gap junction)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045471"(response to ethanol)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0071000"(response to magnetism)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0071253"(connexin binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:0014704"(intercalated disc)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:0016020"(membrane)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035597|interpro:IPR036028|interpro:IPR036034|mint:P39447|rcsb pdb:2RRM|reactome:R-MMU-191650|reactome:R-MMU-2028269|reactome:R-MMU-351906|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|ensembl:ENSMUSG00000030516(gene)|ensembl:ENSMUST00000102592(transcript)|go:"GO:0001825"(blastocyst formation)|refseq:NP_033412.2|dip:DIP-30946N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:wvslyL15GCrtwUReZEC9DiNvPEk10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:F6SEU4	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-5797569|ensembl:ENSMUSP00000141686	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6ZWR6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-10760754|uniprotkb:Q8K3T7|uniprotkb:Q9ERT7|uniprotkb:Q9ERT8	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:syne1_mouse(display_long)|uniprotkb:Synaptic nuclear envelope protein 1(gene name synonym)|uniprotkb:Enaptin(gene name synonym)|uniprotkb:Myocyte nuclear envelope protein 1(gene name synonym)|uniprotkb:Nuclear envelope spectrin repeat protein 1(gene name synonym)|uniprotkb:Syne1(gene name)|psi-mi:Syne1(display_short)|uniprotkb:KASH domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	mint:Q6ZWR6|refseq:NP_001073154.1|go:"GO:0000932"(P-body)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0007030"(Golgi organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030496"(midbody)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051642"(centrosome localization)|go:"GO:0061886"(negative regulation of mini excitatory postsynaptic potential)|go:"GO:0090292"(nuclear matrix anchoring at nuclear membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903353"(regulation of nucleus organization)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR012315(Klarsicht/ANC-1/syne-1 homology)|interpro:IPR018159|interpro:IPR036872|dip:DIP-60966N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:96Ke3lpwOXQNnVBWVhwJaEpeNAM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q61548	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-775174|uniprotkb:Q61547|uniprotkb:Q8K0D4	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ap180_mouse(display_long)|uniprotkb:Clathrin coat-associated protein AP180(gene name synonym)|uniprotkb:91 kDa synaptosomal-associated protein(gene name synonym)|uniprotkb:Phosphoprotein F1-20(gene name synonym)|uniprotkb:Snap91(gene name)|psi-mi:Snap91(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001264911.1|refseq:NP_001264915.1|refseq:NP_038697.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|refseq:XP_006510957.1|refseq:XP_006510963.1|interpro:IPR030428|mint:Q61548|go:"GO:0000149"(SNARE binding)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043679"(axon terminus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1904006"(negative regulation of phospholipase D activity)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:uew/lk0YJ8j0CQULEZaC/qLlLF810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8C3Q5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733755|ensembl:ENSMUSP00000064886|uniprotkb:Q3UMB3|uniprotkb:A0A172Q401|uniprotkb:A0A172Q418	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:shsa7_mouse(display_long)|uniprotkb:"GABA(A) receptor auxiliary subunit Shisa7"(gene name synonym)|uniprotkb:Shisa7(gene name)|psi-mi:Shisa7(display_short)|uniprotkb:Cystine-knot AMPAR modulating protein of 59 kDa(gene name synonym)|uniprotkb:Shisa family member 7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0106040"(regulation of GABA-A receptor activity)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|interpro:IPR026910|mint:Q8C3Q5|ensembl:ENSMUSG00000053550(gene)|ensembl:ENSMUST00000066041(transcript)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0014069"(postsynaptic density)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|refseq:NP_001277220.1|refseq:NP_766325.3|refseq:XP_006539838.1|refseq:XP_011248805.1|refseq:XP_017177636.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:QLd4YuqeuHEYoMVMriatA4ix1Vg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q4ACU6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q80Z38	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-770338|uniprotkb:E9QPH7|uniprotkb:Q3UTK4|uniprotkb:Q5DU07	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:shan2_mouse(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)|uniprotkb:Kiaa1022(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001074839.2|refseq:NP_001106844.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001452(Src homology-3)|refseq:XP_006508596.1|reactome:R-MMU-6794361|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0043005"(neuron projection)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:OTohbAMxKtx7/WWwWXDc+c24HvQ10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:D3YZU1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2314988|ensembl:ENSMUSP00000103571	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:shan1_mouse(display_long)|uniprotkb:Shank1(gene name)|psi-mi:Shank1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001029287.1|refseq:XP_006540927.1|ensembl:ENSMUSG00000038738(gene)|ensembl:ENSMUST00000107938(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|reactome:R-MMU-6794361	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:TbxBmjjabypLqTlAx9zbkSAAzpk10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9Z1S5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-772112|uniprotkb:Q3TNZ2|uniprotkb:Q7TNT7	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:sept3_mouse(display_long)|uniprotkb:Septin3(gene name)|psi-mi:Septin3(display_short)|uniprotkb:Sep3(gene name synonym)|uniprotkb:Sept3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_036019.2|interpro:IPR016491(Septin)|interpro:IPR008114(Septin 3)|interpro:IPR030379|interpro:IPR027417|mint:Q9Z1S5|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005940"(septin ring)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098793"(presynapse)|go:"GO:0099569"(presynaptic cytoskeleton)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:bh+Ipxn2l+rYj60pLw1/8IB04qw10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P63001	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P12849	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-645585|ensembl:ENSMUSP00000026973|ensembl:ENSMUSP00000106515	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kap1_mouse(display_long)|uniprotkb:Prkar1b(gene name)|psi-mi:Prkar1b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_032949.3|refseq:XP_006504723.1|refseq:XP_006504724.1|refseq:XP_006504726.1|refseq:NP_001240819.1|refseq:XP_017176208.1|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0030552"(cAMP binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|go:"GO:0009887"(animal organ morphogenesis)|interpro:IPR018488|interpro:IPR018490|interpro:IPR042818|mint:P12849|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720|reactome:R-MMU-5610787|reactome:R-MMU-983231|ensembl:ENSMUSG00000025855(gene)|ensembl:ENSMUST00000026973(transcript)|ensembl:ENSMUST00000110890(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007611"(learning or memory)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:w65y6gB5uVAjfKjbAidQPpWtgAo10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P63087	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-80040|uniprotkb:O09186|uniprotkb:O09189|uniprotkb:P37139|uniprotkb:Q64679|ensembl:ENSMUSP00000099587	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:pp1g_mouse(display_long)|uniprotkb:Ppp1cc(gene name)|psi-mi:Ppp1cc(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|rcsb pdb:4V0U|rcsb pdb:4V0V|rcsb pdb:4V0W|rcsb pdb:4V0X|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-68877|reactome:R-MMU-9648025|go:"GO:0005856"(cytoskeleton)|ensembl:ENSMUSG00000004455(gene)|ensembl:ENSMUST00000102528(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_038664.2|refseq:XP_006508478.1|refseq:XP_006530263.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:67YjuOIxqIl6Qj+bQnfLBo4iRAg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P62137	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-357187|ensembl:ENSMUSP00000039109|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:Q3U7G7|uniprotkb:Q9Z1G2	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:pp1a_mouse(display_long)|uniprotkb:Ppp1ca(gene name)|psi-mi:Ppp1ca(display_short)|uniprotkb:Ppp1a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62137|rcsb pdb:5ZQV|rcsb pdb:5ZT0|reactome:R-MMU-180024|ensembl:ENSMUSG00000040385(gene)|ensembl:ENSMUST00000046094(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|refseq:NP_114074.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:kr38FkfqhN5ex5rxh4ZJbSdd8IM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q69ZK9	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-775065|uniprotkb:Q5F288|ensembl:ENSMUSP00000053097|ensembl:ENSMUSP00000104274	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:nlgn2_mouse(display_long)|uniprotkb:Nlgn2(gene name)|psi-mi:Nlgn2(display_short)|uniprotkb:Kiaa1366(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_942562.2|refseq:XP_006532964.1|dip:DIP-29702N|ensembl:ENSMUSG00000051790(gene)|ensembl:ENSMUST00000056484(transcript)|ensembl:ENSMUST00000108634(transcript)|go:"GO:0001966"(thigmotaxis)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007630"(jump response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035176"(social behavior)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0072553"(terminal button organization)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1904034"(positive regulation of t-SNARE clustering)|go:"GO:1904862"(inhibitory synapse assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030023|mint:Q69ZK9|rcsb pdb:3BL8|reactome:R-MMU-6794361	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:cSlsVbBCCXq2FW64Fa2J4b6apfA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8CHT1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-911398|uniprotkb:Q8R204|uniprotkb:Q923H2|uniprotkb:Q9JHT9	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ngef_mouse(display_long)|uniprotkb:Eph-interacting exchange protein(gene name synonym)|uniprotkb:Neuronal guanine nucleotide exchange factor(gene name synonym)|uniprotkb:Ngef(gene name)|psi-mi:Ngef(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0030154"(cell differentiation)|go:"GO:0030426"(growth cone)|mint:Q8CHT1|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|reactome:R-MMU-193648|reactome:R-MMU-3928663|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0009987"(cellular process)|go:"GO:0016020"(membrane)|refseq:NP_001104784.1|refseq:NP_063920.2|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|interpro:IPR035635|interpro:IPR035899|interpro:IPR036028	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:6KDlJ/WWKhZ/Gpd3JjtniKfRIiQ10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P46935	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9EPN1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-527731|uniprotkb:Q8C931|uniprotkb:Q9EPM9|uniprotkb:Q9EPN0|uniprotkb:Q9WVM9|ensembl:ENSMUSP00000029374	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:nbea_mouse(display_long)|uniprotkb:Lysosomal-trafficking regulator 2(gene name synonym)|uniprotkb:Nbea(gene name)|psi-mi:Nbea(display_short)|uniprotkb:Lyst2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_085098.1|ensembl:ENSMUSG00000027799(gene)|ensembl:ENSMUST00000029374(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0008104"(protein localization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR010508(Protein of unknown function DUF1088)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023362|interpro:IPR031570|interpro:IPR036322|interpro:IPR036372|mint:Q9EPN1|refseq:XP_006501586.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:NWSzMiK/aQ6zHqkCxAoWJSqnrvA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9WVQ1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-297151|uniprotkb:Q3UH81|uniprotkb:Q6GT88|ensembl:ENSMUSP00000085872|uniprotkb:Q8BYT1|uniprotkb:Q8CA85	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:magi2_mouse(display_long)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Arip1(gene name synonym)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Activin receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000040003(gene)|ensembl:ENSMUST00000088516(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|rcsb pdb:6JJZ|rcsb pdb:6KKG|rcsb pdb:7D6F|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|refseq:NP_001164216.1|refseq:NP_001164217.1|refseq:NP_056638.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:Dj0efnLWnVFm5op5RjDEVBl1NF810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9QXZ0	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-643248|intact:EBI-2658096|uniprotkb:B1ARU3|uniprotkb:Q4PLL5|uniprotkb:P97394|uniprotkb:P97395|uniprotkb:P97396	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:macf1_mouse(display_long)|uniprotkb:Actin cross-linking family 7(gene name synonym)|uniprotkb:Macf1(gene name)|psi-mi:Macf1(display_short)|uniprotkb:Acf7(gene name synonym)|uniprotkb:Aclp7(gene name synonym)|uniprotkb:Macf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR002017(Spectrin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR001101(Plectin repeat)|interpro:IPR018159|interpro:IPR001452(Src homology-3)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0008104"(protein localization)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|mint:Q9QXZ0|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:niJxpkI45VTa5x73A1tuX/aLXgo10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:A2AHG0	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16730688|ensembl:ENSMUSP00000037109|ensembl:ENSMUSP00000086990|uniprotkb:A2AHF9|uniprotkb:Q3TSY0|uniprotkb:Q6PE51	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:lzts3_mouse(display_long)|uniprotkb:ProSAP-interacting protein 1(gene name synonym)|uniprotkb:Lzts3(gene name)|psi-mi:Lzts3(display_short)|uniprotkb:Prosapip1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000037703(gene)|ensembl:ENSMUST00000045761(transcript)|ensembl:ENSMUST00000089561(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0045202"(synapse)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|interpro:IPR033295|refseq:NP_001277956.1|refseq:NP_001277957.1|refseq:NP_922936.3|refseq:XP_017173693.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:5+8Res6l89KP2ziP7nHoTRP25p010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P60853	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733725|ensembl:ENSMUSP00000039397|ensembl:ENSMUSP00000139117|uniprotkb:B2RTI1	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:lzts1_mouse(display_long)|uniprotkb:F37/Esophageal cancer-related gene-coding leucine-zipper motif(gene name synonym)|uniprotkb:Lzts1(gene name)|psi-mi:Lzts1(display_short)|uniprotkb:Fez1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000036306(gene)|ensembl:ENSMUST00000037049(transcript)|ensembl:ENSMUST00000185176(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044297"(cell body)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR033293|refseq:NP_955396.2|refseq:XP_006509669.1|refseq:XP_006509670.1|refseq:XP_006509671.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:j15lauwglUK0sfkEa/y9jDNvqpc10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q08460	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:A2CG49	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-770321|uniprotkb:A2CG50|uniprotkb:A2CG51|uniprotkb:A2CG52|uniprotkb:A2CG53|uniprotkb:Q3TYL1|uniprotkb:Q3UTA5|uniprotkb:Q8BTT9|uniprotkb:Q8C4Q2|uniprotkb:Q9CVA9|uniprotkb:Q3TXY8|uniprotkb:B2RXR5|uniprotkb:D3Z559|ensembl:ENSMUSP00000076088	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kalrn_mouse(display_long)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001157740.1|refseq:XP_006522445.1|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018159|interpro:IPR028570|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSMUSG00000061751(gene)|ensembl:ENSMUST00000076810(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0035176"(social behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042711"(maternal behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046959"(habituation)|mint:A2CG49|rcsb pdb:1WFW|reactome:R-MMU-193648|reactome:R-MMU-3928662|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5687128|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013408|interpro:IPR036865	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:pDqdA2QNbqgLE3eYQXVVW2cxIyo10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q3TES0	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16725408|ensembl:ENSMUSP00000038653|uniprotkb:Q3UHP8|uniprotkb:Q80TJ8	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:iqec3_mouse(display_long)|uniprotkb:Iqsec3(gene name)|psi-mi:Iqsec3(display_short)|uniprotkb:Kiaa1110(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000040797(gene)|ensembl:ENSMUST00000046373(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050808"(synapse organization)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099629"(postsynaptic specialization of symmetric synapse)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR033742|interpro:IPR035999|go:"GO:0060077"(inhibitory synapse)|refseq:NP_001028526.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:ca8BfkMISVCn8R1jxdoGGFCJd3s10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q5DU25	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-773452|uniprotkb:E9QK46	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:iqec2_mouse(display_long)|uniprotkb:Iqsec2(gene name)|psi-mi:Iqsec2(display_short)|uniprotkb:Kiaa0522(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000904(SEC7-like)|interpro:IPR023394|interpro:IPR033742|refseq:XP_006528908.1|interpro:IPR035999|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900454"(positive regulation of long-term synaptic depression)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:D2kDV/pgwPkXPHcK5+7S9+HS6Wk10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9Z2Y3	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q3UVX5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8795045|ensembl:ENSMUSP00000114927	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:grm5_mouse(display_long)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|reactome:R-MMU-416476|reactome:R-MMU-420499|reactome:R-MMU-6794361|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|ensembl:ENSMUSG00000049583(gene)|ensembl:ENSMUST00000155358(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|refseq:XP_011239945.1|refseq:NP_001137306.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:pA3IUBq9r3mGn7M8R2qnAaYqaT810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q01097	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-400125|uniprotkb:Q9DCB2	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P35436	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-400115|ensembl:ENSMUSP00000032331|ensembl:ENSMUSP00000111501|ensembl:ENSMUSP00000142900	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:nmde1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:Grin2a(gene name)|psi-mi:Grin2a(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_032196.2|reactome:R-MMU-8849932|reactome:R-MMU-9609736|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-438066|go:"GO:0098839"(postsynaptic density membrane)|ensembl:ENSMUSG00000059003(gene)|ensembl:ENSMUST00000032331(transcript)|ensembl:ENSMUST00000115835(transcript)|ensembl:ENSMUST00000199708(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040011"(locomotion)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|refseq:XP_006521857.1|dip:DIP-31567N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:5DMFDOh6NuFArDtKp2gp2IpmhWQ10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P35438	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P39087	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-396914|uniprotkb:Q60933|ensembl:ENSMUSP00000101124|ensembl:ENSMUSP00000151921	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:grik2_mouse(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)|uniprotkb:Glutamate receptor beta-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:XP_017169293.1|ensembl:ENSMUSG00000056073(gene)|ensembl:ENSMUST00000105484(transcript)|ensembl:ENSMUST00000218823(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:P39087|reactome:R-MMU-451307|reactome:R-MMU-451308	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:6sgY8SzX07HzilLLeDg3pV+sXkc10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9Z2W9	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-445507|uniprotkb:A2VDF4|uniprotkb:Q5DTJ0|ensembl:ENSMUSP00000075687	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:gria3_mouse(display_long)|uniprotkb:GluR-K3(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 3(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 3(gene name synonym)|uniprotkb:Gria3(gene name)|psi-mi:Gria3(display_short)|uniprotkb:Kiaa4184(gene name synonym)|uniprotkb:Glur3(gene name synonym)|uniprotkb:GluR-C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_058582.3|refseq:XP_006541583.1|refseq:NP_001268858.1|refseq:XP_017174034.1|ensembl:ENSMUSG00000001986(gene)|ensembl:ENSMUST00000076349(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032991"(protein-containing complex)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|go:"GO:0038023"(signaling receptor activity)|interpro:IPR028082|go:"GO:0043025"(neuronal cell body)|mint:Q9Z2W9|rcsb pdb:3LSW|rcsb pdb:3LSX|go:"GO:0043083"(synaptic cleft)|reactome:R-MMU-399710|reactome:R-MMU-399719|reactome:R-MMU-416993|go:"GO:0043195"(terminal bouton)|reactome:R-MMU-438066|go:"GO:0043197"(dendritic spine)|reactome:R-MMU-8849932|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:n9Lnq/kl4co4Th5d/N5JX+cN4yU10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P23819	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-77538|uniprotkb:Q61604|uniprotkb:Q61605|uniprotkb:Q8BG69|uniprotkb:Q8BXU3|uniprotkb:Q9D6D3	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:gria2_mouse(display_long)|uniprotkb:Gria2(gene name)|psi-mi:Gria2(display_short)|uniprotkb:Glur2(gene name synonym)|uniprotkb:GluR-B(gene name synonym)|uniprotkb:GluR-K2(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 2(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051117"(ATPase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|reactome:R-MMU-399710|reactome:R-MMU-416993|reactome:R-MMU-438066|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR028082|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|mint:P23819	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:v71xzThz9kadLOPBasVAc1y/FXs10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P23818	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-445486|ensembl:ENSMUSP00000044494	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:gria1_mouse(display_long)|uniprotkb:GluR-A(gene name synonym)|uniprotkb:GluR-K1(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 1(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 1(gene name synonym)|uniprotkb:Gria1(gene name)|psi-mi:Gria1(display_short)|uniprotkb:Glur1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001106796.1|dip:DIP-31970N|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044297"(cell body)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060076"(excitatory synapse)|go:"GO:0045202"(synapse)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:7LDD|rcsb pdb:7LDE|reactome:R-MMU-204005|reactome:R-MMU-399710|reactome:R-MMU-399719|reactome:R-MMU-416993|ensembl:ENSMUSG00000020524(gene)|ensembl:ENSMUST00000036315(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|reactome:R-MMU-438066|reactome:R-MMU-5694530|reactome:R-MMU-8849932	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:5hAcAV1UEfdgn7CNrrAHPIwUs/410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P35922	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-645094	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q91ZU6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-446159|uniprotkb:Q60845|uniprotkb:Q9WU50|uniprotkb:Q1KP04|uniprotkb:Q3I6J6|uniprotkb:Q8K5D4|uniprotkb:Q91ZU7|uniprotkb:Q91ZU8|uniprotkb:Q60824|uniprotkb:E9PXE5|uniprotkb:E9QL23|uniprotkb:S4R1U5|ensembl:ENSMUSP00000095392	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dyst_mouse(display_long)|uniprotkb:Dystonia musculorum protein(gene name synonym)|uniprotkb:Hemidesmosomal plaque protein(gene name synonym)|uniprotkb:Dst(gene name)|psi-mi:Dst(display_short)|uniprotkb:Bpag1(gene name synonym)|uniprotkb:Macf2(gene name synonym)|uniprotkb:Microtubule actin cross-linking factor 2(gene name synonym)|uniprotkb:Bullous pemphigoid antigen 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_034211.2|refseq:NP_598594.2|refseq:NP_604443.2|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031673"(H zone)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042060"(wound healing)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0046907"(intracellular transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR011992(EF-Hand type)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:Q91ZU6|rcsb pdb:2IAK|reactome:R-MMU-446107|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-9696264|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000026131(gene)|ensembl:ENSMUST00000097785(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:kQkueAqyWyioKh0Hf1vVtIaHRY810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9D415	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q62108	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q91XM9	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-400138|uniprotkb:Q8BXK7|uniprotkb:Q8BYG5|ensembl:ENSMUSP00000102814|uniprotkb:F8VQM7	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dlg2_mouse(display_long)|uniprotkb:Dlg2(gene name)|psi-mi:Dlg2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000052572(gene)|ensembl:ENSMUST00000107196(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035759|interpro:IPR036028|interpro:IPR036034|mint:Q91XM9|rcsb pdb:2WL7|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6794361|refseq:NP_001229976.1|refseq:NP_035937.2|dip:DIP-31569N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:37/IFbjDNxh87dnN2gglIgDGyIU10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q06890	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-774758|ensembl:ENSMUSP00000022616	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:clus_mouse(display_long)|uniprotkb:Sulfated glycoprotein 2(gene name synonym)|uniprotkb:Clustrin(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:Clu(gene name)|psi-mi:Clu(display_short)|uniprotkb:Apoj(gene name synonym)|uniprotkb:Msgp-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_038520.2|refseq:XP_006518567.1|ensembl:ENSMUSG00000022037(gene)|ensembl:ENSMUST00000022616(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002434"(immune complex clearance)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016235"(aggresome)|go:"GO:0017038"(protein import)|go:"GO:0030426"(growth cone)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0071944"(cell periphery)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0099020"(perinuclear endoplasmic reticulum lumen)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902847"(regulation of neuronal signal transduction)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1905892"(negative regulation of cellular response to thapsigargin)|go:"GO:1905895"(negative regulation of cellular response to tunicamycin)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000753(Clusterin-like)|interpro:IPR016014(Clusterin, N-terminal)|interpro:IPR016015(Clusterin, C-terminal)|interpro:IPR016016(Clusterin)|interpro:IPR033986|mint:Q06890|reactome:R-MMU-114608|reactome:R-MMU-166665|reactome:R-MMU-6803157|reactome:R-MMU-977606|go:"GO:0042583"(chromaffin granule)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:wP6AESslzICF3ojv9a+vJUn61VA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q80TV8	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-908322|uniprotkb:Q505G6|uniprotkb:Q6DI75|uniprotkb:Q6PG14|uniprotkb:Q8BNS4|uniprotkb:Q99JH5|uniprotkb:Q99JI2|uniprotkb:Q9CVU1	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:clap1_mouse(display_long)|uniprotkb:Clasp1(gene name)|psi-mi:Clasp1(display_short)|uniprotkb:Cytoplasmic linker-associated protein 1(gene name synonym)|uniprotkb:Kiaa0622(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001280229.1|refseq:NP_001280230.1|refseq:NP_083985.2|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024395|interpro:IPR021133|interpro:IPR028399|interpro:IPR034085|mint:Q80TV8|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0006903"(vesicle targeting)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0030981"(cortical microtubule cytoskeleton)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031592"(centrosomal corona)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0043515"(kinetochore binding)|go:"GO:0045180"(basal cortex)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-2500257	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:HwJCOu/w9CSWzqLB7WEjrC4a3bg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P49025	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-397301|intact:EBI-487846|uniprotkb:O88528|uniprotkb:O88937|uniprotkb:O88938|uniprotkb:Q3UM99|uniprotkb:Q8CIJ1	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ctro_mouse(display_long)|uniprotkb:Cit(gene name)|psi-mi:Cit(display_short)|uniprotkb:Rho-interacting, serine/threonine-protein kinase 21(gene name synonym)|uniprotkb:Crik(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR017405(Citron Rho-interacting kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|refseq:XP_006530214.1|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001726"(ruffle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR037708|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005856"(cytoskeleton)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048699"(generation of neurons)|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-5625900	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:8kykadVIiyk12GjGCZNn0bQ13C010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8R0S4	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-3647752|uniprotkb:Q3UHK2|uniprotkb:Q8BRN6|uniprotkb:Q8CAJ9|ensembl:ENSMUSP00000077438	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cacb4_mouse(display_long)|uniprotkb:Cacnb4(gene name)|psi-mi:Cacnb4(display_short)|uniprotkb:Cacnlb4(gene name synonym)|uniprotkb:Calcium channel voltage-dependent subunit beta 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001272356.1|refseq:XP_011237317.1|refseq:NP_001032176.1|refseq:NP_666235.1|refseq:XP_006497704.1|go:"GO:0045202"(synapse)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050877"(nervous system process)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0055001"(muscle cell development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|reactome:R-MMU-112308|go:"GO:0042391"(regulation of membrane potential)|ensembl:ENSMUSG00000017412(gene)|ensembl:ENSMUST00000078324(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0016607"(nuclear speck)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035249"(synaptic transmission, glutamatergic)|refseq:XP_017170652.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:a2B9SMgAy84Ou3mK3Q6aniE71vQ10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8R3Z5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-644833|uniprotkb:O88517|uniprotkb:Q7TPF2|uniprotkb:Q8R3Z6|uniprotkb:Q9EPT9|uniprotkb:A2A544	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cacb1_mouse(display_long)|uniprotkb:Calcium channel voltage-dependent subunit beta 1(gene name synonym)|uniprotkb:Cacnb1(gene name)|psi-mi:Cacnb1(display_short)|uniprotkb:Cacnlb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001152791.1|refseq:NP_112450.1|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001452(Src homology-3)|interpro:IPR005443(Voltage-dependent calcium channel, L-type, beta-1 subunit)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR027417|rcsb pdb:4ZW2|go:"GO:0030315"(T-tubule)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0098793"(presynapse)|reactome:R-MMU-5576892|reactome:R-MMU-5576893|reactome:R-MMU-112308|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|interpro:IPR036028	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:e7XKbBMDfWDxQMlMoCmj8zyECCI10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:O08532	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-770939|uniprotkb:O08533|uniprotkb:O08534|uniprotkb:O08535|uniprotkb:O08536|ensembl:ENSMUSP00000049457	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ca2d1_mouse(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-1(gene name synonym)|uniprotkb:Cacna2d1(gene name)|psi-mi:Cacna2d1(display_short)|uniprotkb:Cacna2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001104313.1|refseq:NP_001104314.1|refseq:NP_001104315.1|refseq:NP_001104316.1|refseq:NP_033914.1|ensembl:ENSMUSG00000040118(gene)|ensembl:ENSMUST00000039370(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030315"(T-tubule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086048"(membrane depolarization during bundle of His cell action potential)|go:"GO:0086057"(voltage-gated calcium channel activity involved in bundle of His cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1901843"(positive regulation of high voltage-gated calcium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013608(VWA N-terminal)|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR036465|mint:O08532	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:fY8StGDMVTfTBrs3lV7rYVrjvBg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q61290	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-770918	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cac1e_mouse(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 6(gene name synonym)|uniprotkb:Brain calcium channel II(gene name synonym)|uniprotkb:Cacna1e(gene name)|psi-mi:Cacna1e(display_short)|uniprotkb:Cach6(gene name synonym)|uniprotkb:Cacnl1a6(gene name synonym)|uniprotkb:Cchra1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR005449(Voltage-dependent calcium channel, R-type, alpha-1 subunit)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR027359|interpro:IPR031649|go:"GO:0001662"(behavioral fear response)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0042596"(fear response)|go:"GO:0043204"(perikaryon)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048265"(response to pain)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0050877"(nervous system process)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0090273"(regulation of somatostatin secretion)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|reactome:R-MMU-112308|reactome:R-MMU-422356|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042593"(glucose homeostasis)|mint:Q61290	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:EaL/xQzdjloSLb88yMW1gqddCjM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P97445	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-770859|uniprotkb:Q2TPN3|ensembl:ENSMUSP00000112436	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cac1a_mouse(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.1(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 4(gene name synonym)|uniprotkb:Brain calcium channel I(gene name synonym)|uniprotkb:Cacna1a(gene name)|psi-mi:Cacna1a(display_short)|uniprotkb:Cach4(gene name synonym)|uniprotkb:Cacn3(gene name synonym)|uniprotkb:Cacnl1a4(gene name synonym)|uniprotkb:Ccha1a(gene name synonym)|uniprotkb:Caca1a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_031604.3|ensembl:ENSMUSG00000034656(gene)|ensembl:ENSMUST00000121390(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008219"(cell death)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021590"(cerebellum maturation)|go:"GO:0021679"(cerebellar molecular layer development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031335"(regulation of sulfur amino acid metabolic process)|go:"GO:0032353"(negative regulation of hormone biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005448(Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|mint:P97445|reactome:R-MMU-112308|reactome:R-MMU-422356|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050877"(nervous system process)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:0F+rEJNjvjSIeqALxCrthlflD9U10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8BKX1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9WV31	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-397779|ensembl:ENSMUSP00000023268|ensembl:ENSMUSP00000105636|uniprotkb:Q9ES15	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:arc_mouse(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001263613.1|ensembl:ENSMUSG00000022602(gene)|ensembl:ENSMUST00000023268(transcript)|ensembl:ENSMUST00000110009(transcript)|refseq:NP_061260.1|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|dip:DIP-31565N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:vZutgYl26hWTDm9UgMeY8dtgbg810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9DBG3	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-775229|uniprotkb:Q80XJ4|ensembl:ENSMUSP00000070714	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ap2b1_mouse(display_long)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:Ap2b1(gene name)|psi-mi:Ap2b1(display_short)|uniprotkb:Clapb1(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001030931.1|refseq:NP_082191.1|refseq:XP_006534321.1|refseq:XP_017170261.1|dip:DIP-32161N|ensembl:ENSMUSG00000035152(gene)|ensembl:ENSMUST00000065692(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0035904"(aorta development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q9DBG3|rcsb pdb:6OWO|rcsb pdb:6OXL|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:YWwOqRpXCJDwzrLv27muBx1+DHI10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P17427	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-775215|uniprotkb:Q8C2J5|uniprotkb:Q921V0|ensembl:ENSMUSP00000003038	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ap2a2_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)|uniprotkb:Adtab(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_031485.3|dip:DIP-32160N|ensembl:ENSMUSG00000002957(gene)|ensembl:ENSMUST00000003038(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030141"(secretory granule)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:P17427|rcsb pdb:1B9K|rcsb pdb:1KY6|rcsb pdb:1KY7|rcsb pdb:1KYD|rcsb pdb:1KYF|rcsb pdb:1KYU|rcsb pdb:1QTP|rcsb pdb:1QTS|rcsb pdb:1W80|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VJ0|rcsb pdb:3HS8|rcsb pdb:6OWO|rcsb pdb:6OXL|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-6798695|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:KlOjm5d8qxxQkcuD2Hukoj8DLss10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P17426	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-775189|ensembl:ENSMUSP00000082519|ensembl:ENSMUSP00000127842	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ap2a1_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Ap2a1(gene name)|psi-mi:Ap2a1(display_short)|uniprotkb:Adtaa(gene name synonym)|uniprotkb:Clapa1(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001070732.1|refseq:NP_031484.1|ensembl:ENSMUSG00000060279(gene)|ensembl:ENSMUST00000085399(transcript)|ensembl:ENSMUST00000166972(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0032433"(filopodium tip)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:P17426|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:Dd6Q+Et/LTlmo5qpro2Zaeq0dMc10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:G5E8K5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-457262|uniprotkb:G5E8K4|uniprotkb:Q3TSJ8|uniprotkb:Q4U205|uniprotkb:Q4U206|uniprotkb:Q4U256|uniprotkb:Q4U260|uniprotkb:Q61307|uniprotkb:Q8CBN3|uniprotkb:Q8VC68|uniprotkb:O08866|uniprotkb:O08867|uniprotkb:Q61305|uniprotkb:Q61306|uniprotkb:Q61308|uniprotkb:Q61309|uniprotkb:Q61310|intact:EBI-2133089|ensembl:ENSMUSP00000090090|ensembl:ENSMUSP00000138326	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ank3_mouse(display_long)|uniprotkb:Ankyrin-G(gene name synonym)|uniprotkb:Ank3(gene name)|psi-mi:Ank3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_666117.2|refseq:XP_006513202.1|refseq:NP_033800.2|refseq:NP_733788.2|refseq:NP_733789.1|refseq:NP_733790.2|refseq:NP_733791.2|refseq:NP_733924.2|refseq:NP_733925.2|refseq:NP_733926.2|ensembl:ENSMUSG00000069601(gene)|ensembl:ENSMUST00000092434(transcript)|ensembl:ENSMUST00000182884(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010650"(positive regulation of cell communication by electrical coupling)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014704"(intercalated disc)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042383"(sarcolemma)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043194"(axon initial segment)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0050808"(synapse organization)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072660"(maintenance of protein location in plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0099612"(protein localization to axon)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1900827"(positive regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037971|interpro:IPR040745|mint:G5E8K5	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:sPFqnXYHQKlR6xjYE/VqOvNFxG010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8C8R3	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-774322|intact:EBI-2133064|uniprotkb:Q6PCN2|uniprotkb:Q3TM62|uniprotkb:Q3V2X0|uniprotkb:Q80ZZ7|uniprotkb:Q8BNC1|uniprotkb:Q8C445|uniprotkb:Q8CCV0|intact:EBI-2255612|intact:EBI-8314005|intact:MINT-4115219	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ank2_mouse(display_long)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:AnkB(gene name synonym)|uniprotkb:Ank2(gene name)|psi-mi:Ank2(display_short)|uniprotkb:Ankyrin-B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001029340.1|refseq:NP_848770.2|dip:DIP-58645N|mint:Q8C8R3|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001257"(regulation of cation channel activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:SkB13oxZVcKuMnI8r5ItFIq2pXQ10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8K4G5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2307994|uniprotkb:Q80U86|uniprotkb:Q8BIR9|uniprotkb:Q8K4G3|uniprotkb:Q8K4G4	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ablm1_mouse(display_long)|uniprotkb:Ablim1(gene name)|psi-mi:Ablim1(display_short)|uniprotkb:Ablim(gene name synonym)|uniprotkb:Kiaa0059(gene name synonym)|uniprotkb:Actin-binding LIM protein family member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001096647.1|refseq:NP_848803.3|interpro:IPR003128(Villin headpiece)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_001096648.1|refseq:NP_001277742.1|refseq:NP_001277744.1|interpro:IPR032402|interpro:IPR028448|mint:Q8K4G5|interpro:IPR036886|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060271"(cilium assembly)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:UteUUoDaSxN+RrZNRUyx9jrzqHc10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:E9PUD6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16731480|ensembl:ENSMUSP00000047088|ensembl:ENSMUSP00000147550|ensembl:ENSMUSP00000148239	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:e9pud6_mouse(display_long)|uniprotkb:Zscan18(gene name)|psi-mi:Zscan18(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUST00000046245(transcript)|ensembl:ENSMUST00000210650(transcript)|ensembl:ENSMUST00000211392(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR038269|ensembl:ENSMUSG00000070822(gene)|refseq:NP_001017955.2|refseq:XP_006539855.1|refseq:XP_006539856.1|refseq:XP_006539857.1|refseq:XP_011248810.1|refseq:XP_017177637.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:3f9MJ95z+tFR/5DdQFo3uX3w2CU10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8R5H6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-774719|uniprotkb:Q91W51|uniprotkb:Q9ERQ9|ensembl:ENSMUSP00000019975|ensembl:ENSMUSP00000101148	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:wasf1_mouse(display_long)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Wasf1(gene name)|psi-mi:Wasf1(display_short)|uniprotkb:Wave1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_114083.1|refseq:XP_006512995.1|ensembl:ENSMUSG00000019831(gene)|ensembl:ENSMUST00000019975(transcript)|ensembl:ENSMUST00000105509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8R5H6|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013423	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:t+4F2ap7lNjE/AGuIwMhel4YknU10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P70398	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2214043|uniprotkb:E9QLY0|uniprotkb:Q62497	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:usp9x_mouse(display_long)|uniprotkb:Ubiquitin thioesterase FAF-X(gene name synonym)|uniprotkb:Usp9x(gene name)|psi-mi:Usp9x(display_short)|uniprotkb:Fafl(gene name synonym)|uniprotkb:Fam(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-X(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-X(gene name synonym)|uniprotkb:Fat facets protein-related, X-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, X chromosome(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase FAM(gene name synonym)|uniprotkb:Fat facets homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR016024(Armadillo-type fold)|interpro:IPR028889|refseq:NP_033507.2|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:P70398|interpro:IPR038765|interpro:IPR021905|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021698"(cerebellar cortex structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0030426"(growth cone)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045177"(apical part of cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|reactome:R-MMU-2173795|reactome:R-MMU-5689880|reactome:R-MMU-8866652|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-9033241	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:QXx5gkd+PxoNgIj2b2dLjpCuNr410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q7TNM2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-912167|uniprotkb:Q60717|uniprotkb:Q6P1I9|ensembl:ENSMUSP00000036053	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:tri46_mouse(display_long)|uniprotkb:Trim46(gene name)|psi-mi:Trim46(display_short)|uniprotkb:Trific(gene name synonym)|uniprotkb:Tripartite, fibronectin type-III and C-terminal SPRY motif protein(gene name synonym)|uniprotkb:Gene Y protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_898858.1|ensembl:ENSMUSG00000042766(gene)|ensembl:ENSMUST00000041022(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001764"(neuron migration)|go:"GO:0007409"(axonogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0043194"(axon initial segment)|go:"GO:0044304"(main axon)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0099612"(protein localization to axon)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1903827"|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990769"(proximal neuron projection)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017903|interpro:IPR017907|interpro:IPR027370|interpro:IPR035731|interpro:IPR036116|interpro:IPR040859|interpro:IPR043136|mint:Q7TNM2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:W/Zpw91YDw+XPdzjyY9OvQECCfI10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9R1R2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-775991|uniprotkb:Q3UMU5|ensembl:ENSMUSP00000053384|ensembl:ENSMUSP00000102401|ensembl:ENSMUSP00000114822	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:trim3_mouse(display_long)|uniprotkb:RING finger protein 22(gene name synonym)|uniprotkb:RING finger protein HAC1(gene name synonym)|uniprotkb:Trim3(gene name)|psi-mi:Trim3(display_short)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Rnf22(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001272799.1|refseq:NP_001272800.1|refseq:NP_001272802.1|refseq:NP_061368.1|ensembl:ENSMUSG00000036989(gene)|ensembl:ENSMUST00000057525(transcript)|ensembl:ENSMUST00000106789(transcript)|ensembl:ENSMUST00000147044(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001258(NHL repeat)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR017907|interpro:IPR027370|mint:Q9R1R2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:fOQH1BPgmOXrJXOb8VYYFpNX0UQ10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q62318	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-346909|uniprotkb:P70391|uniprotkb:Q8C283|uniprotkb:Q99PN4|ensembl:ENSMUSP00000005705	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:tif1b_mouse(display_long)|uniprotkb:Trim28(gene name)|psi-mi:Trim28(display_short)|uniprotkb:Krip1(gene name synonym)|uniprotkb:Tif1b(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:KRAB-A-interacting protein(gene name synonym)|uniprotkb:KRIP-1(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:Kap1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_035718.2|dip:DIP-31477N|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q62318|rcsb pdb:6O5K|reactome:R-MMU-212436|ensembl:ENSMUSG00000005566(gene)|ensembl:ENSMUST00000005705(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:DvGJxQNohVWs++QEAyrqe4ngcz810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P70399	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-769130|uniprotkb:Q68FD0|uniprotkb:Q8CI97|uniprotkb:Q91YC9|intact:EBI-11051502|intact:EBI-11516626|uniprotkb:A2AU89|uniprotkb:A2AU91|ensembl:ENSMUSP00000106278	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:tp53b_mouse(display_long)|uniprotkb:Tp53bp1(gene name)|psi-mi:Tp53bp1(display_short)|uniprotkb:Trp53bp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001277759.1|refseq:NP_038763.3|dip:DIP-31595N|refseq:XP_011237883.1|ensembl:ENSMUSG00000043909(gene)|ensembl:ENSMUST00000110648(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:P70399|rcsb pdb:1SSF|reactome:R-MMU-3232118|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:z5tOHbR6ApNZRL9aptim/xRaVo010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8BYI9	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-774167|uniprotkb:A2RT70|uniprotkb:O88717|ensembl:ENSMUSP00000107298|ensembl:ENSMUSP00000141553	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:tenr_mouse(display_long)|uniprotkb:Restrictin(gene name synonym)|uniprotkb:Janusin(gene name synonym)|uniprotkb:Neural recognition molecule J1-160/180(gene name synonym)|uniprotkb:Tnr(gene name)|psi-mi:Tnr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_071707.2|refseq:XP_006496805.1|refseq:XP_006496806.1|refseq:XP_006496807.1|ensembl:ENSMUSG00000015829(gene)|ensembl:ENSMUST00000111669(transcript)|ensembl:ENSMUST00000192069(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0045121"(membrane raft)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048692"(negative regulation of axon extension involved in regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072534"(perineuronal net)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098966"(perisynaptic extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR033079|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:Q8BYI9|reactome:R-MMU-3000178	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:K7s7yPGS4RvIe+thCkAZIFGjNRA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6ZQ29	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-11075873|uniprotkb:Q7TSS8|ensembl:ENSMUSP00000112963	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:taok2_mouse(display_long)|uniprotkb:Taok2(gene name)|psi-mi:Taok2(display_short)|uniprotkb:Kiaa0881(gene name synonym)|uniprotkb:Thousand and one amino acid protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001157246.1|refseq:NP_001157247.1|ensembl:ENSMUSG00000059981(gene)|ensembl:ENSMUST00000117394(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007409"(axonogenesis)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030424"(axon)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150019"(basal dendrite morphogenesis)|go:"GO:0150020"(basal dendrite arborization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:3C4cqoGaWAJFiVl7jRPn7kGlaCc10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:A2A690	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733043|ensembl:ENSMUSP00000097904|uniprotkb:A2A683|uniprotkb:Q3TRZ3|uniprotkb:Q5EBP6|uniprotkb:Q69ZQ7	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:tanc2_mouse(display_long)|uniprotkb:Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:Tanc2(gene name)|psi-mi:Tanc2(display_short)|uniprotkb:Kiaa1148(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000053580(gene)|ensembl:ENSMUST00000100330(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0030424"(axon)|go:"GO:0043197"(dendritic spine)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099519"(dense core granule cytoskeletal transport)|interpro:IPR002110(Ankyrin)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:A2A690|refseq:NP_851416.2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:pr3yhn1QUhZm0o9/xXGd9g+QFoo10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9ERG2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-911729|ensembl:ENSMUSP00000013130	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:strn3_mouse(display_long)|uniprotkb:Cell cycle autoantigen SG2NA(gene name synonym)|uniprotkb:S/G2 antigen(gene name synonym)|uniprotkb:Strn3(gene name)|psi-mi:Strn3(display_short)|uniprotkb:Gs2na(gene name synonym)|uniprotkb:Sg2na(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000020954(gene)|ensembl:ENSMUST00000013130(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR001680(WD40 repeat)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|interpro:IPR013258(Striatin, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9ERG2|refseq:NP_443205.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:TdtwkF77kxNiBo0jtPGVLwUlxoI10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:O55106	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2479958|uniprotkb:B2RWV9|uniprotkb:Q5BKR9|ensembl:ENSMUSP00000120830	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:strn_mouse(display_long)|uniprotkb:Strn(gene name)|psi-mi:Strn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000024077(gene)|ensembl:ENSMUST00000145910(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016358"(dendrite development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030425"(dendrite)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR013258(Striatin, N-terminal)|go:"GO:0014069"(postsynaptic density)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:O55106|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9009391|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_035630.2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:tUJDyyIWZKuEBcyJKUIbk2dR4JE10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q68FG2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2255511|ensembl:ENSMUSP00000008991	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:q68fg2_mouse(display_long)|uniprotkb:Sptbn2(gene name)|psi-mi:Sptbn2(display_short)|uniprotkb:Spnb3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_067262.1|refseq:XP_006531767.1|refseq:XP_006531768.1|ensembl:ENSMUSG00000067889(gene)|ensembl:ENSMUST00000008991(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008091"(spectrin)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0030534"(adult behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051693"(actin filament capping)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098918"(structural constituent of synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:0099189"(postsynaptic spectrin-associated cytoskeleton)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-MMU-2132295|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:2F7U0dl21KxXpc9Z2sk7D/wzQvM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q62261	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P16546	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-911063|uniprotkb:A3KGU6|uniprotkb:Q8K380|uniprotkb:Q9CT05|uniprotkb:A3KGU8|ensembl:ENSMUSP00000092697	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:sptn1_mouse(display_long)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym)|uniprotkb:Spta2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	dip:DIP-37712N|ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000095083(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032437"(cuticular plate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:P16546|reactome:R-MMU-264870|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:UVB6Kv+PBlqDH3OLoGjxm5oYVPQ10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6NZL0	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-776265|uniprotkb:Q8BLM2|uniprotkb:Q9CSN3|uniprotkb:Q9CU45|ensembl:ENSMUSP00000090293	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:soga3_mouse(display_long)|uniprotkb:Soga3(gene name)|psi-mi:Soga3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_080414.2|ensembl:ENSMUSG00000038916(gene)|ensembl:ENSMUST00000092629(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|interpro:IPR027881	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:fqFLavYLqmaqDCGT+/GaB6l9h9U10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:A2AQ25	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8821027|ensembl:ENSMUSP00000066170|uniprotkb:A2AUE9|uniprotkb:A2AUF0|uniprotkb:A2AUF1|uniprotkb:Q75UV8|uniprotkb:Q75UV9|uniprotkb:Q80VK2|uniprotkb:Q8BHX8|uniprotkb:Q8BHY1|uniprotkb:Q8CHA8|uniprotkb:Q8R0K6	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:skt_mouse(display_long)|uniprotkb:Skt(gene name)|psi-mi:Skt(display_short)|uniprotkb:Etl4(gene name synonym)|uniprotkb:Kiaa1217(gene name synonym)|uniprotkb:Enhancer trap locus 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR022782|interpro:IPR026725|mint:A2AQ25|ensembl:ENSMUSG00000036617(gene)|ensembl:ENSMUST00000066509(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0048706"(embryonic skeletal system development)|refseq:NP_001074475.1|refseq:NP_001171101.2|refseq:NP_084171.2|refseq:NP_835160.2|refseq:XP_006497478.1|refseq:XP_006497487.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:WI45C2F/GFoa1PhVnBHPtxCj5mM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8R550	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-642709|uniprotkb:Q8CAL8|uniprotkb:Q8CEF6|uniprotkb:Q8R545|uniprotkb:Q8R546|uniprotkb:Q8R547|uniprotkb:Q8R548|uniprotkb:Q8R549|uniprotkb:Q8R551|uniprotkb:Q9CTQ9|uniprotkb:Q9DC14|uniprotkb:Q9JKC3|uniprotkb:B1AZ86|uniprotkb:B1AZ87|ensembl:ENSMUSP00000072840	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:sh3k1_mouse(display_long)|uniprotkb:SH3-containing, expressed in tumorigenic astrocytes(gene name synonym)|uniprotkb:Regulator of ubiquitous kinase(gene name synonym)|uniprotkb:Sh3kbp1(gene name)|psi-mi:Sh3kbp1(display_short)|uniprotkb:Ruk(gene name synonym)|uniprotkb:Seta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001129199.1|refseq:NP_001129200.1|refseq:NP_067364.2|refseq:XP_006528987.1|ensembl:ENSMUSG00000040990(gene)|ensembl:ENSMUST00000073094(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q8R550|rcsb pdb:1WI7|rcsb pdb:2DA9|rcsb pdb:5XHZ|reactome:R-MMU-182971|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866376|reactome:R-MMU-983695|refseq:XP_011246151.1|refseq:XP_011246153.1|refseq:NP_001277590.1|refseq:NP_001277593.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:Fd7WikE+fZIgob7Ax2vr9J291N010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q99NE5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-775541|uniprotkb:Q5DU35|uniprotkb:Q5J8K0|uniprotkb:Q5J8K1|uniprotkb:Q5J8K2|uniprotkb:Q5J8K3|uniprotkb:Q5J8K4	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:rims1_mouse(display_long)|uniprotkb:Rab-3-interacting molecule 1(gene name synonym)|uniprotkb:Rab-3-interacting protein 1(gene name synonym)|uniprotkb:Rims1(gene name)|psi-mi:Rims1(display_short)|uniprotkb:Rab3ip1(gene name synonym)|uniprotkb:Rim1(gene name synonym)|uniprotkb:Kiaa0340(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001012641.1|refseq:NP_001012642.1|refseq:NP_001012643.1|refseq:NP_444500.1|refseq:NP_898839.2|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010911(Rab-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR039032|interpro:IPR035892|interpro:IPR036034|interpro:IPR041282|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-888590|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010808"(positive regulation of synaptic vesicle priming)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:EimJngs4cAg6YQgqO36VmSuTlRM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q80U40	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733698|uniprotkb:B9EKT4|uniprotkb:E9QPF5	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:rimb2_mouse(display_long)|uniprotkb:Rimbp2(gene name)|psi-mi:Rimbp2(display_short)|uniprotkb:Kiaa0318(gene name synonym)|uniprotkb:Rbp2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	interpro:IPR040325|go:"GO:0005886"(plasma membrane)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|refseq:NP_001074857.1|refseq:NP_001297662.1|interpro:IPR003961(Fibronectin, type III)|interpro:IPR036116|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR035753|interpro:IPR035755|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR035519	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:4qKzUEy3VglZ19Y9CuD4js6I+5010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9EQZ6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-772212|uniprotkb:Q8VIP9|uniprotkb:Q9CW52|uniprotkb:Q9Z1P0|ensembl:ENSMUSP00000088336	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:rpgf4_mouse(display_long)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor II(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 2(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 2(gene name synonym)|uniprotkb:cAMP-dependent Rap1 guanine-nucleotide exchange factor(gene name synonym)|uniprotkb:Rapgef4(gene name)|psi-mi:Rapgef4(display_short)|uniprotkb:Cgef2(gene name synonym)|uniprotkb:Epac2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_062662.1|refseq:NP_001191094.1|refseq:NP_001191095.1|dip:DIP-32333N|ensembl:ENSMUSG00000049044(gene)|ensembl:ENSMUST00000090826(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030552"(cAMP binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044316"(cone cell pedicle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1904457"(positive regulation of neuronal action potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|rcsb pdb:1O7F|rcsb pdb:2BYV|rcsb pdb:3CF6|rcsb pdb:4F7Z|rcsb pdb:4MGI|rcsb pdb:4MGK|rcsb pdb:4MGY|rcsb pdb:4MGZ|rcsb pdb:4MH0|reactome:R-MMU-354192|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:E6oFNR3wXazvvq3wWWxfn4CW5F410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P69566	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-772305|uniprotkb:P84500|uniprotkb:Q3V136	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ranb9_mouse(display_long)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:B-cell antigen receptor Ig beta-associated protein 1(gene name synonym)|uniprotkb:Ranbp9(gene name)|psi-mi:Ranbp9(display_short)|uniprotkb:Ranbpm(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_064314.2|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|mint:P69566|interpro:IPR035782|interpro:IPR043136|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-MMU-373760|reactome:R-MMU-5673001|reactome:R-MMU-8851805	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:nKjsQ+KN8Z4mWEyQcRejUCLSDJY10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P42669	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-773823|ensembl:ENSMUSP00000059404	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:pura_mouse(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:Pura(gene name)|psi-mi:Pura(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_033015.1|refseq:XP_006525787.1|refseq:XP_011245162.1|ensembl:ENSMUSG00000043991(gene)|ensembl:ENSMUST00000051301(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:P42669	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:3LVZ5qdZYeJyeUVPhy3cozxROWs10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:B0V2N1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-647877|uniprotkb:Q3TEC3|uniprotkb:Q3TXC9|uniprotkb:Q5XJV4|uniprotkb:Q64503|uniprotkb:Q64699|uniprotkb:Q7TT17|uniprotkb:Q4JFC7|ensembl:ENSMUSP00000064048	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ptprs_mouse(display_long)|uniprotkb:Ptprs(gene name)|psi-mi:Ptprs(display_short)|uniprotkb:Receptor-type tyrosine-protein phosphatase sigma(gene name synonym)|uniprotkb:PTPNU-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_035348.2|refseq:NP_001239382.1|refseq:NP_001239384.1|refseq:NP_001239385.1|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|mint:B0V2N1|rcsb pdb:3SR9|reactome:R-MMU-388844|reactome:R-MMU-8849932|ensembl:ENSMUSG00000013236(gene)|ensembl:ENSMUST00000067538(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008201"(heparin binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021510"(spinal cord development)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:ZHccWWvEOOQcSSD7ic6ow6xeqtU10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q64487	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-771834|uniprotkb:Q64486|uniprotkb:Q64488|uniprotkb:Q64495|intact:EBI-6132324|intact:EBI-5778480|uniprotkb:G3X9S7|uniprotkb:Q8VBV0|ensembl:ENSMUSP00000102910	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ptprd_mouse(display_long)|uniprotkb:Ptprd(gene name)|psi-mi:Ptprd(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_035341.2|ensembl:ENSMUSG00000028399(gene)|ensembl:ENSMUST00000107289(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099545"(trans-synaptic signaling by trans-synaptic complex)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|rcsb pdb:4Y61|rcsb pdb:4YFD|rcsb pdb:4YFE|rcsb pdb:4YFG|rcsb pdb:4YH7|rcsb pdb:5XWT|rcsb pdb:5XWU|rcsb pdb:5Y32|rcsb pdb:6KIP|rcsb pdb:7CEG|reactome:R-MMU-388844|reactome:R-MMU-8849932	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:FkLHZVFqjCRQ5GQ+76uKWFhBYYg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P63318	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-397096|uniprotkb:P05697|ensembl:ENSMUSP00000097874	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kpcg_mouse(display_long)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_035232.1|ensembl:ENSMUSG00000078816(gene)|ensembl:ENSMUST00000100301(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0005829"(cytosol)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|interpro:IPR020454|interpro:IPR035892|mint:P63318|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-416993|reactome:R-MMU-5099900|reactome:R-MMU-76005	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P68404	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P31324	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-455340|uniprotkb:Q3UTZ1|uniprotkb:Q80ZM4|uniprotkb:Q8BRZ7|uniprotkb:B1B199|ensembl:ENSMUSP00000003079|ensembl:ENSMUSP00000039797	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kap3_mouse(display_long)|uniprotkb:Prkar2b(gene name)|psi-mi:Prkar2b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_035288.2|refseq:XP_006515077.1|dip:DIP-31571N|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P31324|rcsb pdb:3TNP|rcsb pdb:3TNQ|rcsb pdb:4WBB|rcsb pdb:4X6Q|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-432040|reactome:R-MMU-442720|reactome:R-MMU-5610787|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-983231|ensembl:ENSMUSG00000002997(gene)|ensembl:ENSMUST00000003079(transcript)|ensembl:ENSMUST00000036497(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007612"(learning)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0097332"(response to antipsychotic drug)|go:"GO:0097546"(ciliary base)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0097338"(response to clozapine)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:/d/0NSAnglWjmZAcQUn6ATpbJnE10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P68181	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-400685|uniprotkb:P05206|uniprotkb:Q3TQH5|uniprotkb:Q3UDD0|uniprotkb:Q3UTH5|ensembl:ENSMUSP00000099573	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kapcb_mouse(display_long)|uniprotkb:Prkacb(gene name)|psi-mi:Prkacb(display_short)|uniprotkb:Pkacb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001157670.1|refseq:NP_001157671.1|refseq:NP_001157672.1|refseq:NP_035230.1|ensembl:ENSMUSG00000005034(gene)|ensembl:ENSMUST00000102515(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0097338"(response to clozapine)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044109|mint:P68181|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356|reactome:R-MMU-432040|reactome:R-MMU-4420097|reactome:R-MMU-442720|reactome:R-MMU-5610785|reactome:R-MMU-5610787|reactome:R-MMU-5621575|reactome:R-MMU-5687128|reactome:R-MMU-8853659|reactome:R-MMU-8963896|reactome:R-MMU-983231	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:9278c8xZsjU90+vryXpzUc0y/G010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P05132	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-400564|uniprotkb:Q9JID0|ensembl:ENSMUSP00000005606	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kapca_mouse(display_long)|uniprotkb:Prkaca(gene name)|psi-mi:Prkaca(display_short)|uniprotkb:Pkaca(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001264827.1|refseq:NP_032880.1|reactome:R-MMU-8963896|reactome:R-MMU-983231|ensembl:ENSMUSG00000005469(gene)|go:"GO:0097546"(ciliary base)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044109|mint:P05132|ensembl:ENSMUST00000005606(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048792"(spontaneous exocytosis of neurotransmitter)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0097225"(sperm midpiece)|rcsb pdb:1APM|rcsb pdb:1ATP|rcsb pdb:1BKX|rcsb pdb:1BX6|rcsb pdb:1FMO|rcsb pdb:1J3H|rcsb pdb:1JBP|rcsb pdb:1JLU|rcsb pdb:1L3R|rcsb pdb:1PVK|rcsb pdb:1RDQ|rcsb pdb:1RE8|rcsb pdb:1REJ|rcsb pdb:1REK|rcsb pdb:1SYK|rcsb pdb:2CPK|rcsb pdb:2ERZ|rcsb pdb:2QCS|rcsb pdb:2QUR|rcsb pdb:2QVS|rcsb pdb:3FHI|rcsb pdb:3FJQ|rcsb pdb:3IDB|rcsb pdb:3IDC|rcsb pdb:3J4Q|rcsb pdb:3J4R|rcsb pdb:3O7L|rcsb pdb:3OW3|rcsb pdb:3PVB|rcsb pdb:3QAL|rcsb pdb:3QAM|rcsb pdb:3TNP|rcsb pdb:3TNQ|rcsb pdb:3X2U|rcsb pdb:3X2V|rcsb pdb:3X2W|rcsb pdb:4DFX|rcsb pdb:4DFY|rcsb pdb:4DFZ|rcsb pdb:4DG0|rcsb pdb:4DG2|rcsb pdb:4DG3|rcsb pdb:4DH1|rcsb pdb:4DH3|rcsb pdb:4DH5|rcsb pdb:4DH7|rcsb pdb:4DH8|rcsb pdb:4DIN|rcsb pdb:4HPT|rcsb pdb:4HPU|rcsb pdb:4IAC|rcsb pdb:4IAD|rcsb pdb:4IAF|rcsb pdb:4IAI|rcsb pdb:4IAK|rcsb pdb:4IAY|rcsb pdb:4IAZ|rcsb pdb:4IB0|rcsb pdb:4IB1|rcsb pdb:4IB3|rcsb pdb:4NTS|rcsb pdb:4NTT|rcsb pdb:4O21|rcsb pdb:4O22|rcsb pdb:4WBB|rcsb pdb:4X6Q|rcsb pdb:4X6R|rcsb pdb:4XW4|rcsb pdb:4XW5|rcsb pdb:4XW6|rcsb pdb:5JR7|rcsb pdb:5X3F|rcsb pdb:6E21|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|rcsb pdb:6MM8|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356|reactome:R-MMU-432040|reactome:R-MMU-4420097|reactome:R-MMU-442720|reactome:R-MMU-512988|reactome:R-MMU-5578775|reactome:R-MMU-5610785|reactome:R-MMU-5610787|reactome:R-MMU-5620912|reactome:R-MMU-5621575|reactome:R-MMU-5687128|reactome:R-MMU-8853659|reactome:R-MMU-8854518|dip:DIP-6086N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:HdW51RuiujpUxo0Fu8TbWz3Yk8c10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q76MZ3	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-400413|ensembl:ENSMUSP00000007708	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:2aaa_mouse(display_long)|uniprotkb:Ppp2r1a(gene name)|psi-mi:Ppp2r1a(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_058587.1|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:Q76MZ3|rcsb pdb:2IAE|rcsb pdb:2PF4|rcsb pdb:3FGA|rcsb pdb:6EF4|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2995383|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-975957|ensembl:ENSMUSG00000007564(gene)|ensembl:ENSMUST00000007708(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051232"(meiotic spindle elongation)|dip:DIP-29429N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:0tnO11U1SNOOT46j23f7dim8O8k10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:E9Q6H8	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733655|ensembl:ENSMUSP00000084904	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:e9q6h8_mouse(display_long)|uniprotkb:Plekha5(gene name)|psi-mi:Plekha5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUST00000087622(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0061458"(reproductive system development)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036020|interpro:IPR040392|reactome:R-MMU-1660499|ensembl:ENSMUSG00000030231(gene)|refseq:NP_659169.3|refseq:XP_017176796.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:95A53f3GXyHpkue5XX1HS9JzUSg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8C437	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-775487|uniprotkb:Q8CA31|uniprotkb:Q9DAA1|uniprotkb:Q9JMB9	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:pex5r_mouse(display_long)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:Pex5l(gene name)|psi-mi:Pex5l(display_short)|uniprotkb:Pex2(gene name synonym)|uniprotkb:Pex5r(gene name synonym)|uniprotkb:Pxr2(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001156989.1|interpro:IPR024112|interpro:IPR024111|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001156988.1|rcsb pdb:4EQF|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043235"(receptor complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:IMtSiiXNgSaJMG0zqLJXYs4zqpg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q80YT7	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q7TSK3	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733620|ensembl:ENSMUSP00000045333|uniprotkb:Q05BD0|uniprotkb:Q8C824|uniprotkb:Q9JKP3	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:pcdh8_mouse(display_long)|uniprotkb:Arcadlin(gene name synonym)|uniprotkb:Paraxial protocadherin(gene name synonym)|uniprotkb:Pcdh8(gene name)|psi-mi:Pcdh8(display_short)|uniprotkb:Papc(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000036422(gene)|ensembl:ENSMUST00000039568(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0030425"(dendrite)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045202"(synapse)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|interpro:IPR002126(Cadherin)|interpro:IPR013164(Cadherin, N-terminal)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR030711|refseq:NP_001036191.1|refseq:NP_067518.2	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:YZGWnE83v8k3vDQrS/mFrEBAhME10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8C015	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16728624|ensembl:ENSMUSP00000047285|ensembl:ENSMUSP00000076440|uniprotkb:Q3TQJ7|uniprotkb:Q6RWS7	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:pak5_mouse(display_long)|uniprotkb:p21-activated kinase 5(gene name synonym)|uniprotkb:p21-activated kinase 7(gene name synonym)|uniprotkb:Pak5(gene name)|psi-mi:Pak5(display_short)|uniprotkb:Pak7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000039913(gene)|ensembl:ENSMUST00000035264(transcript)|ensembl:ENSMUST00000077200(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028754|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013407|reactome:R-MMU-9013405|refseq:NP_766446.2|refseq:XP_006499572.1|refseq:XP_011237833.1|refseq:XP_017173706.1|refseq:XP_017173707.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:3r3/hAkAlWB3xoa0zEbeVJxDBy010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P46460	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-398006|uniprotkb:A2A646|uniprotkb:Q8BQ65|uniprotkb:Q8C3R2|uniprotkb:Q8CCT9|uniprotkb:Q8CEF0|uniprotkb:Q923C6|ensembl:ENSMUSP00000099364	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:nsf_mouse(display_long)|uniprotkb:Nsf(gene name)|psi-mi:Nsf(display_short)|uniprotkb:Skd2(gene name synonym)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 2"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_032766.2|ensembl:ENSMUSG00000034187(gene)|ensembl:ENSMUST00000103075(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46460|reactome:R-MMU-204005|reactome:R-MMU-416993|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811438|reactome:R-MMU-6811440	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:mqNfvBVWEdD4caFZug82c88vwE410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9Z0J4	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-397596|uniprotkb:Q64208|uniprotkb:Q3UR10|ensembl:ENSMUSP00000120421|ensembl:ENSMUSP00000127432	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:nos1_mouse(display_long)|uniprotkb:Nos1(gene name)|psi-mi:Nos1(display_short)|uniprotkb:bNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_032738.1|refseq:XP_017176196.1|dip:DIP-31556N|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099163"(synaptic signaling by nitric oxide)|go:"GO:0140196"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:0070402"(NADPH binding)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042582"(azurophil granule)|go:"GO:0042738"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044305"(calyx of Held)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0061875"(negative regulation of hepatic stellate cell contraction)|go:"GO:0032991"(protein-containing complex)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR001094(Flavodoxin-like)|interpro:IPR039261|rcsb pdb:2O60|reactome:R-MMU-1222556|reactome:R-MMU-392154|reactome:R-MMU-5578775|ensembl:ENSMUSG00000029361(gene)|ensembl:ENSMUST00000142742(transcript)|ensembl:ENSMUST00000171055(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030141"(secretory granule)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:BuPBvQk0jEhDNZNi82D3OidmYwE10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P28660	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6P9S0	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733590|ensembl:ENSMUSP00000050211|uniprotkb:Q8C7B7	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:mtss2_mouse(display_long)|uniprotkb:Mtss2(gene name)|psi-mi:Mtss2(display_short)|uniprotkb:MTSS1-like protein(gene name synonym)|uniprotkb:Mtss1l(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000033763(gene)|ensembl:ENSMUST00000052457(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0061024"(membrane organization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097178"(ruffle assembly)|go:"GO:0097581"(lamellipodium organization)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR030127|interpro:IPR030059|refseq:NP_001297520.1|refseq:NP_941027.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:QLFyDjfJiMMNaGYy0+3thxidImY10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6PEB6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-775389|uniprotkb:Q3TS21|uniprotkb:Q8BSA3|uniprotkb:Q9CX28|ensembl:ENSMUSP00000125415	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:phocn_mouse(display_long)|uniprotkb:Mob4(gene name)|psi-mi:Mob4(display_short)|uniprotkb:Class II mMOB1(gene name synonym)|uniprotkb:Mob1 homolog 3(gene name synonym)|uniprotkb:Mob3(gene name synonym)|uniprotkb:Mobkl3(gene name synonym)|uniprotkb:Mps one binder kinase activator-like 3(gene name synonym)|uniprotkb:Phocn(gene name synonym)|uniprotkb:Prei3(gene name synonym)|uniprotkb:Preimplantation protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_079559.2|ensembl:ENSMUSG00000025979(gene)|ensembl:ENSMUST00000162364(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR005301(Mob1/phocein)|interpro:IPR036703	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:ihsb3qrdGqwKdh6ZhHlJlwBGJbc10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P63085	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q80TE7	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-774900	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:lrrc7_mouse(display_long)|uniprotkb:Protein LAP1(gene name synonym)|uniprotkb:Densin-180(gene name synonym)|uniprotkb:Lrrc7(gene name)|psi-mi:Lrrc7(display_short)|uniprotkb:Kiaa1365(gene name synonym)|uniprotkb:Lap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001278381.1|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR032675|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR036034|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6798695|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043194"(axon initial segment)|go:"GO:0043197"(dendritic spine)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:QWCdfe/eQM/ZaaAG2GwZi+Rf87Q10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q922S8	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-10989794|ensembl:ENSMUSP00000064261|uniprotkb:A2AE71	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kif2c_mouse(display_long)|uniprotkb:Kif2c(gene name)|psi-mi:Kif2c(display_short)|uniprotkb:Mitotic centromere-associated kinesin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_608301.3|ensembl:ENSMUSG00000028678(gene)|ensembl:ENSMUST00000065896(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|rcsb pdb:1V8J|rcsb pdb:1V8K|rcsb pdb:5XJA|rcsb pdb:5XJB|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-6811434|reactome:R-MMU-68877|reactome:R-MMU-9648025|reactome:R-MMU-983189|go:"GO:0005634"(nucleus)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:WAnrlbkope7txWJvChOH4p3aMdw10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P28740	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-776122|uniprotkb:O54744|uniprotkb:Q91W03|ensembl:ENSMUSP00000022204	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kif2a_mouse(display_long)|uniprotkb:Kif2a(gene name)|psi-mi:Kif2a(display_short)|uniprotkb:Kif2(gene name synonym)|uniprotkb:Kns2(gene name synonym)|uniprotkb:Kinesin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001139251.1|refseq:XP_006517602.1|ensembl:ENSMUSG00000021693(gene)|ensembl:ENSMUST00000022204(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0051301"(cell division)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097228"(sperm principal piece)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P28740|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-6811434|reactome:R-MMU-68877|reactome:R-MMU-9648025|reactome:R-MMU-983189	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:xPWg0rzeKQooA3AM2Ics+e/QnRM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8R0S2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-772277|uniprotkb:Q3TZC3|uniprotkb:Q5DU15|ensembl:ENSMUSP00000098712	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:iqec1_mouse(display_long)|uniprotkb:Iqsec1(gene name)|psi-mi:Iqsec1(display_short)|uniprotkb:Kiaa0763(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001127855.1|ensembl:ENSMUSG00000034312(gene)|ensembl:ENSMUST00000101153(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR030737|interpro:IPR033742|interpro:IPR035999	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:BZg7CaLndE4ak8KXs34YFf9iBRQ10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P46660	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-400482|uniprotkb:Q61958|uniprotkb:Q8VCW5|ensembl:ENSMUSP00000041347	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ainx_mouse(display_long)|uniprotkb:Ina(gene name)|psi-mi:Ina(display_short)|uniprotkb:66 kDa neurofilament protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_666212.3|ensembl:ENSMUSG00000034336(gene)|ensembl:ENSMUST00000037636(transcript)|go:"GO:0005883"(neurofilament)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027703|interpro:IPR039008|mint:P46660	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:amjP0AajB8s2oXmV96wzyfz6evE10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q7TMY8	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:O88704	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P15105	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-444858|uniprotkb:Q3TRK7|uniprotkb:Q64432|uniprotkb:Q91VC6|ensembl:ENSMUSP00000083375|ensembl:ENSMUSP00000123157	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:glna_mouse(display_long)|uniprotkb:Glutamate--ammonia ligase(gene name synonym)|uniprotkb:Glul(gene name)|psi-mi:Glul(display_short)|uniprotkb:Glns(gene name synonym)|uniprotkb:Palmitoyltransferase GLUL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_032157.2|go:"GO:0030145"(manganese ion binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0097386"(glial cell projection)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR008146(Glutamine synthetase, catalytic region)|interpro:IPR008147(Glutamine synthetase, beta-Grasp)|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR027302|interpro:IPR027303|interpro:IPR036651|mint:P15105|reactome:R-MMU-210455|reactome:R-MMU-8964539|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|ensembl:ENSMUSG00000026473(gene)|ensembl:ENSMUST00000086199(transcript)|ensembl:ENSMUST00000140685(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0004356"(glutamate-ammonia ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006542"(glutamine biosynthetic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0016595"(glutamate binding)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019676"(ammonia assimilation cycle)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:j6R9fxGLKpiREWpecpdnBY9ftoo10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q68FF6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-645933|ensembl:ENSMUSP00000037210	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P13020	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-445180|uniprotkb:Q3UPB1|uniprotkb:Q8R590|intact:EBI-4281654|ensembl:ENSMUSP00000028239	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:gels_mouse(display_long)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Brevin(gene name synonym)|uniprotkb:Gsn(gene name)|psi-mi:Gsn(display_short)|uniprotkb:Gsb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_666232.2|ensembl:ENSMUSG00000026879(gene)|ensembl:ENSMUST00000028239(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030478"(actin cap)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036313"(phosphatidylinositol 3-kinase catalytic subunit binding)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043209"(myelin sheath)|go:"GO:0045010"(actin nucleation)|go:"GO:0045159"(myosin II binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0051593"(response to folic acid)|go:"GO:0051693"(actin filament capping)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060271"(cilium assembly)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0097017"(renal protein absorption)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1903903"(regulation of establishment of T cell polarity)|go:"GO:1903906"(regulation of plasma membrane raft polarization)|go:"GO:1903909"(regulation of receptor clustering)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR030004|mint:P13020|rcsb pdb:1NPH|rcsb pdb:4CBU|rcsb pdb:4CBW|rcsb pdb:4CBX|rcsb pdb:5MVV|rcsb pdb:6I4D|rcsb pdb:6I4E|rcsb pdb:6I4F|rcsb pdb:6I4G|rcsb pdb:6I4H|rcsb pdb:6I4I|rcsb pdb:6I4J|rcsb pdb:6I4K|rcsb pdb:6I4L|rcsb pdb:6I4M|reactome:R-MMU-264870|reactome:R-MMU-6798695|dip:DIP-31941N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:vByKB6qbsPzebkkufeXoP6n0SUI10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6P9Q6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-5745700|uniprotkb:Q3TSY4|uniprotkb:Q5SQG3|uniprotkb:Q80TU5|ensembl:ENSMUSP00000081575	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:fkb15_mouse(display_long)|uniprotkb:Fkbp15(gene name)|psi-mi:Fkbp15(display_short)|uniprotkb:Fkbp133(gene name synonym)|uniprotkb:Kiaa0674(gene name synonym)|uniprotkb:133 kDa FK506-binding protein(gene name synonym)|uniprotkb:WASP and FKBP-like(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001038993.1|refseq:XP_006538097.1|ensembl:ENSMUSG00000066151(gene)|ensembl:ENSMUST00000084527(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003779"(actin binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006897"(endocytosis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:gDB5l8pi67+tU1sQCm2P77ypWC810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6PH08	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16726089|ensembl:ENSMUSP00000147886|uniprotkb:Q80U20|uniprotkb:Q8CCP1	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:erc2_mouse(display_long)|uniprotkb:CAZ-associated structural protein 1(gene name synonym)|uniprotkb:Erc2(gene name)|psi-mi:Erc2(display_short)|uniprotkb:Cast1(gene name synonym)|uniprotkb:D14Ertd171e(gene name synonym)|uniprotkb:Kiaa0378(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000040640(gene)|ensembl:ENSMUST00000211145(transcript)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048790"(maintenance of presynaptic active zone structure)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|interpro:IPR019323|interpro:IPR030625|refseq:NP_808482.2|refseq:XP_006519013.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:bmubXKmJ7vf/Hxo37UGDaxgYamM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9R0P5	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-1184008|ensembl:ENSMUSP00000099461	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dest_mouse(display_long)|uniprotkb:Dstn(gene name)|psi-mi:Dstn(display_short)|uniprotkb:Dsn(gene name synonym)|uniprotkb:Sid23(gene name synonym)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Sid 23(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_062745.1|ensembl:ENSMUSG00000015932(gene)|ensembl:ENSMUST00000103172(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR029006|interpro:IPR029924|mint:Q9R0P5	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:hqPae8VWEKvGPITqHtrSs78yI4M10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:O08553	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-446064|uniprotkb:Q6P5D0|ensembl:ENSMUSP00000022629	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dpyl2_mouse(display_long)|uniprotkb:Unc-33-like phosphoprotein 2(gene name synonym)|uniprotkb:Dpysl2(gene name)|psi-mi:Dpysl2(display_short)|uniprotkb:Crmp2(gene name synonym)|uniprotkb:Ulip2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_034085.2|ensembl:ENSMUSG00000022048(gene)|ensembl:ENSMUST00000022629(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043209"(myelin sheath)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098793"(presynapse)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030615|interpro:IPR032466|mint:O08553|rcsb pdb:5UQC|reactome:R-MMU-399956|reactome:R-MMU-437239	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:97yc8TNEPMcGtGNRLvl+KV+DYr010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P39053	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-397785|ensembl:ENSMUSP00000122679|uniprotkb:A2AN50|uniprotkb:A2AN51|uniprotkb:A2AN54|uniprotkb:A2AN55|uniprotkb:Q3UNM1|uniprotkb:Q5DTN7|uniprotkb:Q61358|uniprotkb:Q61359|uniprotkb:Q61360|uniprotkb:Q6PDM5|uniprotkb:Q8JZZ4|uniprotkb:Q9CSY7|uniprotkb:Q9QXX1	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dyn1_mouse(display_long)|uniprotkb:Dnm1(gene name)|psi-mi:Dnm1(display_short)|uniprotkb:Dnm(gene name synonym)|uniprotkb:Kiaa4093(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_034195.2|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:P39053|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|ensembl:ENSMUSG00000026825(gene)|ensembl:ENSMUST00000139624(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904645"(response to amyloid-beta)|refseq:NP_001288666.1|refseq:XP_006497721.2|refseq:XP_006497722.2|refseq:XP_006497723.2|refseq:XP_006497724.2|refseq:XP_006497718.2|refseq:XP_017170817.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:wtPz3gwyxU6tAgh5091LQpt099I10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P70175	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-396969|ensembl:ENSMUSP00000085299	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dlg3_mouse(display_long)|uniprotkb:Dlg3(gene name)|psi-mi:Dlg3(display_short)|uniprotkb:Dlgh3(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_058027.1|refseq:NP_001171249.1|ensembl:ENSMUSG00000000881(gene)|ensembl:ENSMUST00000087984(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|mint:P70175|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-6794361|reactome:R-MMU-8849932|dip:DIP-31585N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:9dR9P876v8QcvPinxtaWzDgpHwE10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q811D0	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-514290|uniprotkb:Q62402|uniprotkb:Q6PGB5|uniprotkb:Q8CGN7|ensembl:ENSMUSP00000097581|ensembl:ENSMUSP00000110859	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dlg1_mouse(display_long)|uniprotkb:Synapse-associated protein 97(gene name synonym)|uniprotkb:Embryo-dlg/synapse-associated protein 97(gene name synonym)|uniprotkb:Dlg1(gene name)|psi-mi:Dlg1(display_short)|uniprotkb:Dlgh1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_031888.2|refseq:NP_001239362.1|refseq:NP_001239364.1|refseq:XP_006521831.1|refseq:NP_001239363.1|dip:DIP-31591N|ensembl:ENSMUSG00000022770(gene)|ensembl:ENSMUST00000100001(transcript)|ensembl:ENSMUST00000115205(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034629"|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043219"(lateral loop)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060022"(hard palate development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1902473"(regulation of protein localization to synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903286"(regulation of potassium ion import)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903760"(regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:1903764"(regulation of potassium ion export across plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR015143(L27-1)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q811D0|rcsb pdb:4OAJ|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-8849932	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:b8LjYbiuR2K6/jxhwU1hxBJKX6410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:D3YWQ0	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16733539|ensembl:ENSMUSP00000099071|uniprotkb:D3Z2W1	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dgki_mouse(display_long)|uniprotkb:Dgki(gene name)|psi-mi:Dgki(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098891"(extrinsic component of presynaptic active zone membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000756(Diacylglycerol kinase accessory region)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR002110(Ankyrin)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037607|reactome:R-MMU-114508|go:"GO:0060076"(excitatory synapse)|ensembl:ENSMUSG00000038665(gene)|ensembl:ENSMUST00000101532(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0045202"(synapse)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0005829"(cytosol)|go:"GO:0046834"(lipid phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046959"(habituation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|refseq:NP_001074675.1|refseq:NP_001334033.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:lmBf/Q1tVETNnRy0MUe+8Oi/rrI10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9JLM8	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-771719|uniprotkb:Q6P207|ensembl:ENSMUSP00000050034	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:dclk1_mouse(display_long)|uniprotkb:Doublecortin-like and CAM kinase-like 1(gene name synonym)|uniprotkb:Dclk1(gene name)|psi-mi:Dclk1(display_short)|uniprotkb:Dclk(gene name synonym)|uniprotkb:Dcamkl1(gene name synonym)|uniprotkb:Doublecortin-like kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_064362.1|ensembl:ENSMUSG00000027797(gene)|ensembl:ENSMUST00000054237(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0009615"(response to virus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030900"(forebrain development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003533(Doublecortin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036572|mint:Q9JLM8	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:P3ZZ2GyKcdMimAcekZ8OlLbuciM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q5SQX6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q7TMB8	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:B9EJA2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16726062|ensembl:ENSMUSP00000088089|uniprotkb:G3X9L7|uniprotkb:Q69ZB2|uniprotkb:Q8BVG1|uniprotkb:Q8C044	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cttb2_mouse(display_long)|uniprotkb:Cttnbp2(gene name)|psi-mi:Cttnbp2(display_short)|uniprotkb:Kiaa1758(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUST00000090601(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR002110(Ankyrin)|interpro:IPR019131|interpro:IPR020683|interpro:IPR036770|ensembl:ENSMUSG00000000416(gene)|refseq:NP_525024.1|refseq:XP_006505167.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:DCSkzHQr+dNIdM9ELmeBWbxVryg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:O35927	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-774108|uniprotkb:B2RR80	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ctnd2_mouse(display_long)|uniprotkb:Neural plakophilin-related ARM-repeat protein(gene name synonym)|uniprotkb:Neurojungin(gene name synonym)|uniprotkb:Ctnnd2(gene name)|psi-mi:Ctnnd2(display_short)|uniprotkb:Catnd2(gene name synonym)|uniprotkb:Nprap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0045296"(cadherin binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR028435|refseq:NP_032755.2|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|mint:O35927	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:/YXEXiU6UKZhK6McB762K0GKcN010090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P30999	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-529924|uniprotkb:Q3TSU9|uniprotkb:Q80XQ4|uniprotkb:Q8CHF8|ensembl:ENSMUSP00000064518|ensembl:ENSMUSP00000107320|ensembl:ENSMUSP00000141166	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ctnd1_mouse(display_long)|uniprotkb:Kiaa0384(gene name synonym)|uniprotkb:p120 catenin(gene name synonym)|uniprotkb:Cadherin-associated Src substrate(gene name synonym)|uniprotkb:"p120(cas)"(gene name synonym)|uniprotkb:Ctnnd1(gene name)|psi-mi:Ctnnd1(display_short)|uniprotkb:Catns(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001078917.1|refseq:NP_001078918.1|refseq:NP_001078919.1|refseq:NP_001078922.1|refseq:NP_031641.2|refseq:XP_006498698.1|refseq:XP_017170690.1|refseq:XP_017170697.1|dip:DIP-31972N|ensembl:ENSMUSG00000034101(gene)|ensembl:ENSMUSG00000101645(gene)|ensembl:ENSMUST00000067232(transcript)|ensembl:ENSMUST00000111691(transcript)|ensembl:ENSMUST00000189772(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001822"(kidney development)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016600"(flotillin complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0043197"(dendritic spine)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060690"(epithelial cell differentiation involved in salivary gland development)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|interpro:IPR028439|mint:P30999|reactome:R-MMU-418990|reactome:R-MMU-5218920	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:CvcAbgejB5iLlsSAxt47G/6W3P410090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q02248	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q61301	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-774089|uniprotkb:Q61300|uniprotkb:Q6AXD1|uniprotkb:Q3TY37|ensembl:ENSMUSP00000124376	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ctna2_mouse(display_long)|uniprotkb:Alpha N-catenin(gene name synonym)|uniprotkb:Ctnna2(gene name)|psi-mi:Ctnna2(display_short)|uniprotkb:Catna2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001103234.1|refseq:NP_033949.2|refseq:NP_663785.2|dip:DIP-31971N|refseq:XP_011239496.1|refseq:XP_017176861.1|ensembl:ENSMUSG00000063063(gene)|ensembl:ENSMUST00000159626(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030046|interpro:IPR036723|mint:Q61301|rcsb pdb:4K1O|rcsb pdb:4ONS|rcsb pdb:4P9T|rcsb pdb:5XFL|rcsb pdb:6DUY|reactome:R-MMU-525793	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:0z1O3ZeQwbjZawJfbXvb+dGAWYU10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P16330	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-772515|uniprotkb:Q61424|uniprotkb:Q8C7C9|uniprotkb:Q91V42|uniprotkb:Q923F3|ensembl:ENSMUSP00000099409	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cn37_mouse(display_long)|uniprotkb:Cnp(gene name)|psi-mi:Cnp(display_short)|uniprotkb:Cnp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001139790.1|refseq:NP_034053.2|refseq:XP_017169734.1|ensembl:ENSMUSG00000006782(gene)|ensembl:ENSMUST00000103120(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003723"(RNA binding)|go:"GO:0004113"(2',3'-cyclic-nucleotide 3'-phosphodiesterase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009214"(cyclic nucleotide catabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030551"(cyclic nucleotide binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031143"(pseudopodium)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|interpro:IPR008431(Cyclic nucleotide phosphodiesterase)|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|interpro:IPR027417|mint:P16330|rcsb pdb:2XMI|rcsb pdb:2Y1P|rcsb pdb:2Y3X|rcsb pdb:2YDB|rcsb pdb:2YDC|rcsb pdb:2YDD|rcsb pdb:2YOZ|rcsb pdb:2YP0|rcsb pdb:2YPC|rcsb pdb:2YPE|rcsb pdb:2YPH|rcsb pdb:2YQ9|rcsb pdb:3ZBR|rcsb pdb:3ZBS|rcsb pdb:3ZBZ|rcsb pdb:4WBI|rcsb pdb:4WBL|rcsb pdb:4WC9|rcsb pdb:4WCA|rcsb pdb:4WCB|rcsb pdb:4WCC|rcsb pdb:4WDA|rcsb pdb:4WDB|rcsb pdb:4WDD|rcsb pdb:4WDE|rcsb pdb:4WDF|rcsb pdb:4WDG|rcsb pdb:4WDH|rcsb pdb:4WEX|rcsb pdb:4WFR|rcsb pdb:5AE0	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:z0XniuUAwQzaZTvQmEmctKYNw9810090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q80YA9	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q80U49	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16728053|ensembl:ENSMUSP00000098580|ensembl:ENSMUSP00000137331|ensembl:ENSMUSP00000152451|uniprotkb:Q3UH33|uniprotkb:Q3UHG1|uniprotkb:Q80UM2	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:c170b_mouse(display_long)|uniprotkb:Centrosomal protein 170B(gene name synonym)|uniprotkb:Cep170b(gene name)|psi-mi:Cep170b(display_short)|uniprotkb:Kiaa0284(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000072825(gene)|ensembl:ENSMUST00000101018(transcript)|ensembl:ENSMUST00000179041(transcript)|ensembl:ENSMUST00000222711(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029300|refseq:NP_001019773.2|refseq:XP_006515829.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:vmI/x564L8rTcob6vkmQLu2+JCQ10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6A065	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2554140|uniprotkb:Q7TQD9|uniprotkb:Q8BJW2|uniprotkb:Q9D3Z0|ensembl:ENSMUSP00000141793	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:ce170_mouse(display_long)|uniprotkb:Kiaa0470(gene name synonym)|uniprotkb:Cep170(gene name)|psi-mi:Cep170(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000057335(gene)|ensembl:ENSMUST00000194727(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q6A065|refseq:XP_006497000.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:gawEp+b6DVpUroRU0JHmHzo7qPg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P15116	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-397974|uniprotkb:Q64260|uniprotkb:Q6GU11|intact:EBI-2255565|ensembl:ENSMUSP00000025166	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cadh2_mouse(display_long)|uniprotkb:Cdh2(gene name)|psi-mi:Cdh2(display_short)|uniprotkb:Neural cadherin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_031690.3|ensembl:ENSMUSG00000024304(gene)|ensembl:ENSMUST00000025166(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030315"(T-tubule)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|interpro:IPR027397|interpro:IPR030051|interpro:IPR039808|mint:P15116|rcsb pdb:1NCG|rcsb pdb:1NCH|rcsb pdb:1NCI|rcsb pdb:1NCJ|rcsb pdb:1OP4|rcsb pdb:2QVI|rcsb pdb:3Q2W|rcsb pdb:4NUM|rcsb pdb:4NUP|rcsb pdb:4NUQ|reactome:R-MMU-381426|reactome:R-MMU-418990|reactome:R-MMU-525793|reactome:R-MMU-8957275|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090497"(mesenchymal cell migration)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|go:"GO:0043005"(neuron projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|dip:DIP-31564N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:Yon1udPwyvjKP2+GVGUcrsZtFng10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P70408	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-16727790|ensembl:ENSMUSP00000042199|ensembl:ENSMUSP00000128782|uniprotkb:Q3UUB3|uniprotkb:Q80WS7	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cad10_mouse(display_long)|uniprotkb:T2-cadherin(gene name synonym)|uniprotkb:Cdh10(gene name)|psi-mi:Cdh10(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000022321(gene)|ensembl:ENSMUST00000040562(transcript)|ensembl:ENSMUST00000166873(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0034332"(adherens junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR039808|rcsb pdb:6CG6|reactome:R-MMU-418990|refseq:NP_001303687.1|refseq:NP_033995.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:qcFZ51oDbh6HtvjWFmjiIAzscmM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:O70589	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-771402|uniprotkb:A2ADP8|uniprotkb:A2ADP9|uniprotkb:A2ADQ4|uniprotkb:O70588|uniprotkb:Q3UW92	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cskp_mouse(display_long)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Cask(gene name)|psi-mi:Cask(display_short)|uniprotkb:Lin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001271432.1|refseq:NP_001271433.1|refseq:NP_001271434.1|refseq:NP_033936.2|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR011009(Protein kinase-like)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O70589|go:"GO:0060170"(ciliary membrane)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097440"(apical dendrite)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098846"(podocyte foot)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|rcsb pdb:1Y74|rcsb pdb:6Y9O|reactome:R-MMU-212676|reactome:R-MMU-6794361|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:3co6JdI4q/n5C8zGb5JYFL2t7pc10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q9CYT6	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-6666048|ensembl:ENSMUSP00000021802|uniprotkb:Q80YU7|uniprotkb:Q9D6L0	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:cap2_mouse(display_long)|uniprotkb:Cap2(gene name)|psi-mi:Cap2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000021373(gene)|ensembl:ENSMUST00000021802(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045761"(regulation of adenylate cyclase activity)|interpro:IPR001837(Adenylate cyclase-associated CAP)|interpro:IPR006599(CARP motif)|interpro:IPR013912(Adenylate cyclase-associated CAP,  C-terminal)|interpro:IPR013992(Adenylate cyclase-associated CAP, N-terminal)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR018106|interpro:IPR028417|interpro:IPR028418|interpro:IPR036222|interpro:IPR036223|mint:Q9CYT6|refseq:NP_080332.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:iQZCcKXtPvIgU3MHJd24eOdz5HA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q3UHL1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-771778|uniprotkb:Q8VD20|ensembl:ENSMUSP00000040430	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:camkv_mouse(display_long)|uniprotkb:Camkv(gene name)|psi-mi:Camkv(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_663596.1|refseq:XP_006511785.1|ensembl:ENSMUSG00000032936(gene)|ensembl:ENSMUST00000035700(transcript)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|mint:Q3UHL1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:MJKDl/5XBCLsNw3CrNkwzC9zqYI10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q923T9	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-771638|uniprotkb:Q3U3H3|uniprotkb:Q8VED3|ensembl:ENSMUSP00000071720	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kcc2g_mouse(display_long)|uniprotkb:Camk2g(gene name)|psi-mi:Camk2g(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001034227.1|refseq:NP_001034228.1|refseq:NP_848712.2|ensembl:ENSMUSG00000021820(gene)|ensembl:ENSMUST00000071816(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q923T9|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:pbJqcEUQJQRnAwcKozmS72n9s1w10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6PHZ2	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-2308458|uniprotkb:Q3UF87|uniprotkb:Q3UQH9|uniprotkb:Q5DTK4|uniprotkb:Q8CAC5|uniprotkb:Q9CZE2|ensembl:ENSMUSP00000143504	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kcc2d_mouse(display_long)|uniprotkb:Camk2d(gene name)|psi-mi:Camk2d(display_short)|uniprotkb:Kiaa4163(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001020609.1|refseq:NP_076302.1|refseq:NP_001020610.1|refseq:NP_001280592.1|refseq:NP_001280593.1|dip:DIP-47638N|ensembl:ENSMUSG00000053819(gene)|ensembl:ENSMUST00000199300(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031432"(titin binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q6PHZ2|rcsb pdb:6BAB|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:z2mz73Kq9gwpKgo2Todn0IxQpSI10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P28652	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P11798	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8CGU1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-972374|ensembl:ENSMUSP00000023818|uniprotkb:Q5DTX0|uniprotkb:Q9D935	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:caco1_mouse(display_long)|uniprotkb:Calcoco1(gene name)|psi-mi:Calcoco1(display_short)|uniprotkb:CocoA(gene name synonym)|uniprotkb:Kiaa1536(gene name synonym)|uniprotkb:Coiled-coil coactivator protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000023055(gene)|ensembl:ENSMUST00000023818(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0070016"(armadillo repeat domain binding)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|refseq:NP_080468.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:8o6ahpVzsvD8LhyYRkdw5sE7Ufg10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:O08539	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-775152|uniprotkb:Q62434|ensembl:ENSMUSP00000025239	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:bin1_mouse(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:SH3 domain-containing protein 9(gene name synonym)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Sh3p9(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_033798.1|refseq:XP_006526056.1|ensembl:ENSMUSG00000024381(gene)|ensembl:ENSMUST00000025239(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O08539|reactome:R-MMU-8856828	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:VdFcKXTcbayNaahmrT13Dju7kLo10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q6PAJ1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-6271726|ensembl:ENSMUSP00000126377|uniprotkb:E9PZL3|uniprotkb:Q61339|uniprotkb:Q6ZPE5|uniprotkb:Q99LW5	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:bcr_mouse(display_long)|uniprotkb:Bcr(gene name)|psi-mi:Bcr(display_short)|uniprotkb:Kiaa3017(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000009681(gene)|ensembl:ENSMUST00000164107(transcript)|go:"GO:0002692"(negative regulation of cellular extravasation)|go:"GO:0003014"(renal system process)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043197"(dendritic spine)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051171"(regulation of nitrogen compound metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060268"(negative regulation of respiratory burst)|go:"GO:0060313"(negative regulation of blood vessel remodeling)|go:"GO:0065002"(intracellular protein transmembrane transport)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0014069"(postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000198(RhoGAP)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR015123(Bcr-Abl oncoprotein oligomerisation)|interpro:IPR035892|interpro:IPR035899|interpro:IPR036481|interpro:IPR037769|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_001074881.1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:JTsOT1EJiIrOlQlKncjeKv6E7yM10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q60875	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-772191|uniprotkb:E9QNW9|uniprotkb:O09115|uniprotkb:Q3TBI4|uniprotkb:Q3TJ16|uniprotkb:Q8CHE1|uniprotkb:Q923E0|uniprotkb:Q9ESG7|ensembl:ENSMUSP00000029694	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:arhg2_mouse(display_long)|uniprotkb:Kiaa0651(gene name synonym)|uniprotkb:Lbcl1(gene name synonym)|uniprotkb:Lfc(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Lymphoid blast crisis-like 1(gene name synonym)|uniprotkb:LBC'S first cousin(gene name synonym)|uniprotkb:Oncogene LFC(gene name synonym)|uniprotkb:Rhobin(gene name synonym)|uniprotkb:Arhgef2(gene name)|psi-mi:Arhgef2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001185840.1|refseq:NP_001185841.1|refseq:NP_001185842.1|refseq:NP_032513.3|refseq:XP_006501130.1|ensembl:ENSMUSG00000028059(gene)|ensembl:ENSMUST00000029694(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002102"(podosome)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071802"(negative regulation of podosome assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037806|interpro:IPR041020|mint:Q60875|rcsb pdb:5WI4|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:Le4PMm1AT/ManVpetNT2wBsUlok10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P59281	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-772284|uniprotkb:Q69ZD4|uniprotkb:Q6P9R6|ensembl:ENSMUSP00000036697	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:rhg39_mouse(display_long)|uniprotkb:Arhgap39(gene name)|psi-mi:Arhgap39(display_short)|uniprotkb:D15Wsu169e(gene name synonym)|uniprotkb:Kiaa1688(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001161760.1|refseq:NP_940812.2|ensembl:ENSMUSG00000033697(gene)|ensembl:ENSMUST00000036176(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007165"(signal transduction)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036020|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9035034	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:Bm7bwXl6puNRxWYdWzAQynmHJ/E10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q70FJ1	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-645887|uniprotkb:Q3TH74|uniprotkb:Q80TR6	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:akap9_mouse(display_long)|uniprotkb:Akap9(gene name)|psi-mi:Akap9(display_short)|uniprotkb:Kiaa0803(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_919444.2|interpro:IPR019528|interpro:IPR028745|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007165"(signal transduction)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034705"(potassium channel complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044307"(dendritic branch)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097729"(9+2 motile cilium)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0120219"(subapical part of cell)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903358"(regulation of Golgi organization)|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5576890|reactome:R-MMU-5576893|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:Q70FJ1	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:9yyCeoX35wNULJg413iGM9TIQxA10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q3UHD9	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-771911|uniprotkb:Q5DU45|ensembl:ENSMUSP00000043466	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:agap2_mouse(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Kiaa0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_001028435.1|refseq:NP_001287943.1|ensembl:ENSMUSG00000025422(gene)|ensembl:ENSMUST00000039259(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|go:"GO:0005768"(endosome)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:yq2lQtfk+FPqgT++CxAx2CS69nE10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:P62484	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-15791842|ensembl:ENSMUSP00000058754|uniprotkb:Q6PHU3	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:abi2_mouse(display_long)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:Abi2(gene name)|psi-mi:Abi2(display_short)|uniprotkb:Abelson interactor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	ensembl:ENSMUSG00000026782(gene)|ensembl:ENSMUST00000052332(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007611"(learning or memory)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_001185499.1|refseq:NP_001185500.1|refseq:NP_937760.1|dip:DIP-48418N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:A5p3uqPuid61N78yiLHbnxA64mQ10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83510	uniprotkb:Q8CBW3	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734044|imex:IM-26285-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/01/23	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	rigid:uL8ZVsGuSBSolhbQOUeCFCv29+Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P11499	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-492813|uniprotkb:O89078|uniprotkb:Q3UIQ7|ensembl:ENSMUSP00000024739	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:hs90b_mouse(display_long)|uniprotkb:Heat shock 84 kDa(gene name synonym)|uniprotkb:Tumor-specific transplantation 84 kDa antigen(gene name synonym)|uniprotkb:Hsp90ab1(gene name)|psi-mi:Hsp90ab1(display_short)|uniprotkb:Hsp84(gene name synonym)|uniprotkb:Hsp84-1(gene name synonym)|uniprotkb:Hspcb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_032328.2|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P11499|reactome:R-MMU-168928|reactome:R-MMU-2029482|reactome:R-MMU-3371497|reactome:R-MMU-3371511|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-399954|reactome:R-MMU-6798695|reactome:R-MMU-844456|reactome:R-MMU-8852276|reactome:R-MMU-8937144|reactome:R-MMU-8939211|reactome:R-MMU-9013418|reactome:R-MMU-9018519|ensembl:ENSMUSG00000023944(gene)|ensembl:ENSMUST00000024739(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|dip:DIP-461N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:5/MXDESVXdwuWna0s87Ap19aLMA10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9D1D4	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-6999360|ensembl:ENSMUSP00000037583|uniprotkb:Q6P227|uniprotkb:Q3U7I7|intact:MINT-1863252|uniprotkb:Q922U8	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:tmeda_mouse(display_long)|uniprotkb:Tmed10(gene name)|psi-mi:Tmed10(display_short)|uniprotkb:Tmp21(gene name synonym)|uniprotkb:21 kDa transmembrane-trafficking protein(gene name synonym)|uniprotkb:Transmembrane protein Tmp21(gene name synonym)|uniprotkb:p24 family protein delta-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000021248(gene)|ensembl:ENSMUST00000040766(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035964"(COPI-coated vesicle budding)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0048199"(vesicle targeting, to, from or within Golgi)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0106272"(protein localization to ERGIC)|go:"GO:0106273"(cytosol to ERGIC protein transport)|go:"GO:1902003"(regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|mint:Q9D1D4|reactome:R-MMU-204005|reactome:R-MMU-5694530|reactome:R-MMU-6807878|reactome:R-MMU-6811434|go:"GO:0030658"(transport vesicle membrane)|refseq:NP_081051.1	-	-	comment:mint|function:Involved in vesicular protein trafficking	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:2yUHxM9g4N5wIB8hmL7zQ4BluMc10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q91W18	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-8329718|uniprotkb:Q8C1A4|uniprotkb:Q8BZW6|intact:UNK-5479555|intact:MINT-4137349|uniprotkb:E9Q2Q4|intact:UNK-5512156|uniprotkb:Q6NZG7|ensembl:ENSMUSP00000129019	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:tdrd3_mouse(display_long)|uniprotkb:Tdrd3(gene name)|psi-mi:Tdrd3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001240684.1|refseq:NP_766193.3|ensembl:ENSMUSG00000022019(gene)|ensembl:ENSMUST00000168275(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006397"(mRNA processing)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035145"(exon-exon junction complex)|interpro:IPR002999(Tudor)|interpro:IPR009060(UBA-like)|interpro:IPR010304(Survival motor neuron)|interpro:IPR013894(Region of unknown function DUF1767)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR033472|interpro:IPR041915|interpro:IPR042470|mint:Q91W18|rcsb pdb:2D9T	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:OJkc6E7+tTHuVr5BSCn8MtiApZk10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P62715	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-8028975|uniprotkb:P11082|intact:UNK-5382027|ensembl:ENSMUSP00000009774	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:pp2ab_mouse(display_long)|uniprotkb:Ppp2cb(gene name)|psi-mi:Ppp2cb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_059070.1|ensembl:ENSMUSG00000009630(gene)|ensembl:ENSMUST00000009774(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P62715|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-9648025	-	-	function:PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase|comment:mint|comment:homomint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9CQ22	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-8328730|uniprotkb:Q9CYS0|intact:MINT-1870311|intact:MINT-4124770|ensembl:ENSMUSP00000033131	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:ltor1_mouse(display_long)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Lamtor1(gene name)|psi-mi:Lamtor1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_079881.2|ensembl:ENSMUSG00000030842(gene)|ensembl:ENSMUST00000033131(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0051020"(GTPase binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR028209|mint:Q9CQ22|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6798695|reactome:R-MMU-8943724|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9639288	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:DDzxcCbfpNbaFdldFxAR1QuFpXE10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9WVR4	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-8572772|uniprotkb:Q9WVR5|intact:UNK-5560063	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:fxr2_mouse(display_long)|uniprotkb:Fxr2(gene name)|psi-mi:Fxr2(display_short)|uniprotkb:Fxr2h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	interpro:IPR032172|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0045182"(translation regulator activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR022034|interpro:IPR008395(Agenet)|interpro:IPR004088(K Homology, type 1)|interpro:IPR040472|interpro:IPR040148|interpro:IPR036612|interpro:IPR041560	-	-	function:RNA-binding protein|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:q56uykuU0MnJ8r9/CdCuFG+ML0M10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q61584	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	-	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9R0M0	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-8294754|uniprotkb:A2AEE7|intact:MINT-5202369|uniprotkb:Q9Z2R4|uniprotkb:Q99K26|ensembl:ENSMUSP00000088046	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:celr2_mouse(display_long)|uniprotkb:Celsr2(gene name)|psi-mi:Celsr2(display_short)|uniprotkb:Flamingo homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_059088.2|ensembl:ENSMUST00000090558(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0003341"(cilium movement)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSMUSG00000068740(gene)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0021591"(ventricular system development)|go:"GO:0021999"(neural plate anterior/posterior regionalization)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000203(GPS)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001791(Laminin G)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR002126(Cadherin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015919(Cadherin-like)|interpro:IPR017981|interpro:IPR020894|interpro:IPR032471|interpro:IPR036445	-	-	comment:mint|function:Receptor that may have an important role in cell/cell signaling during nervous system formation	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:wPmtsYNVGZrtMfXD5UyeAIjTm7Y10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9DBT5	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-7780420|ensembl:ENSMUSP00000099697|ensembl:ENSMUSP00000099698|intact:MINT-4616236|uniprotkb:Q91YI2|uniprotkb:A2AE28	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:ampd2_mouse(display_long)|uniprotkb:Ampd2(gene name)|psi-mi:Ampd2(display_short)|uniprotkb:AMP deaminase isoform L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000027889(gene)|ensembl:ENSMUST00000102637(transcript)|ensembl:ENSMUST00000102638(transcript)|go:"GO:0003876"(AMP deaminase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006188"(IMP biosynthetic process)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0032264"(IMP salvage)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0052652"(cyclic purine nucleotide metabolic process)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0097009"(energy homeostasis)|interpro:IPR001365(Adenosine/AMP deaminase)|interpro:IPR006329(AMP deaminase)|interpro:IPR006650(Adenosine/AMP deaminase active site)|interpro:IPR029749|interpro:IPR032466|mint:Q9DBT5|reactome:R-MMU-74217|go:"GO:0046039"(GTP metabolic process)|refseq:NP_083055.1|refseq:NP_001276648.1|refseq:NP_001276649.1	-	-	comment:mint|function:AMP deaminase plays a critical role in energy metabolism	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:2i3EpQywgM8qHEU2v1fMCpn/Xes10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q811P8	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-6949116|ensembl:ENSMUSP00000133898|intact:MINT-268399|uniprotkb:B9EHJ8|uniprotkb:Q6A010	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:rhg32_mouse(display_long)|uniprotkb:RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling(gene name synonym)|uniprotkb:Rics(gene name synonym)|uniprotkb:p200RhoGAP(gene name synonym)|uniprotkb:p250GAP(gene name synonym)|uniprotkb:Arhgap32(gene name)|psi-mi:Arhgap32(display_short)|uniprotkb:Brain-specific Rho GTPase-activating protein(gene name synonym)|uniprotkb:GAB-associated Cdc42/Rac GTPase-activating protein(gene name synonym)|uniprotkb:GC-GAP(gene name synonym)|uniprotkb:Grit(gene name synonym)|uniprotkb:Kiaa0712(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 32(gene name synonym)|uniprotkb:Rho/Cdc42/Rac GTPase-activating protein RICS(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000041444(gene)|ensembl:ENSMUST00000174641(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001650"(fibrillar center)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005938"(cell cortex)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0043197"(dendritic spine)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036028|interpro:IPR036871|interpro:IPR042139|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-9035034|refseq:NP_796353.3|refseq:NP_001182561.1	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:4ZVZeciVms1xmC18riIhaDt9wMY10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q61037	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-7924402|uniprotkb:Q61007|uniprotkb:Q61008|uniprotkb:P97724|uniprotkb:P97727|uniprotkb:P97725|intact:MINT-5068541|uniprotkb:Q9WUF6|uniprotkb:P97723	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:tsc2_mouse(display_long)|uniprotkb:Tuberous sclerosis 2 protein homolog(gene name synonym)|uniprotkb:Tsc2(gene name)|psi-mi:Tsc2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	interpro:IPR018515|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024584|mint:Q61037|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|reactome:R-MMU-1632852|reactome:R-MMU-165181|reactome:R-MMU-198323|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035176"(social behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043276"(anoikis)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0030426"(growth cone)|interpro:IPR027107|interpro:IPR035974	-	-	function:Implicated as a tumor suppressor. May have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Specifically stimulates the intrinsic GTPase activity of the ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth|comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:Sw17BM+O0FRiPsuF0+h8V/MedTM10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P83510	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	-	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P51150	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-8321380|intact:MINT-1864693|ensembl:ENSMUSP00000092658|ensembl:ENSMUSP00000109226|ensembl:ENSMUSP00000109227|ensembl:ENSMUSP00000109228|ensembl:ENSMUSP00000109230	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:rab7a_mouse(display_long)|uniprotkb:Rab7a(gene name)|psi-mi:Rab7a(display_short)|uniprotkb:Rab7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001280581.1|refseq:NP_001280582.1|refseq:NP_001280583.1|refseq:NP_001280584.1|refseq:NP_033031.2|dip:DIP-60513N|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-9013148|ensembl:ENSMUSG00000079477(gene)|ensembl:ENSMUST00000095048(transcript)|ensembl:ENSMUST00000113596(transcript)|ensembl:ENSMUST00000113597(transcript)|ensembl:ENSMUST00000113598(transcript)|ensembl:ENSMUST00000113600(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007174"(epidermal growth factor catabolic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032419"(extrinsic component of lysosome membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045453"(bone resorption)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0061724"(lipophagy)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099638"(endosome to plasma membrane protein transport)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1905394"(retromer complex binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P51150|rcsb pdb:5Z2M|reactome:R-MMU-2132295|reactome:R-MMU-6798695|reactome:R-MMU-8854214|reactome:R-MMU-8873719|reactome:R-MMU-8876198	-	-	comment:mint|function:"Involved in late endocytic transport. Contributes to the maturation of phagosomes (acidification)"	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:AJbKizzw4zCAn+roRF2Im1Tt4xE10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q921M7	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-8321269|intact:MINT-4094888|ensembl:ENSMUSP00000066359|ensembl:ENSMUSP00000132486|ensembl:ENSMUSP00000154320	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:cyrib_mouse(display_long)|uniprotkb:Cyrib(gene name)|psi-mi:Cyrib(display_short)|uniprotkb:Cyri(gene name synonym)|uniprotkb:Fam49b(gene name synonym)|uniprotkb:Protein FAM49B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:XP_011243867.1|refseq:XP_011243865.1|refseq:NP_659095.1|refseq:XP_006520824.1|refseq:XP_006520826.1|refseq:XP_006520827.1|ensembl:ENSMUSG00000022378(gene)|ensembl:ENSMUST00000063838(transcript)|ensembl:ENSMUST00000164532(transcript)|ensembl:ENSMUST00000228226(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0023030"(MHC class Ib protein binding, via antigen binding groove)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000568"(positive regulation of memory T cell activation)|interpro:IPR009828(Protein of unknown function DUF1394)|interpro:IPR039789|mint:Q921M7|rcsb pdb:7AJL|reactome:R-MMU-114608	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:TKMOyqWPIodr3CdX53oO2MiyXHY10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9JMC3	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-8344673|uniprotkb:Q543S9|uniprotkb:Q9CUD4|intact:MINT-4093187|uniprotkb:Q9CTD6|uniprotkb:B2RW09|ensembl:ENSMUSP00000070413|ensembl:ENSMUSP00000112520	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:dnja4_mouse(display_long)|uniprotkb:Dnaja4(gene name)|psi-mi:Dnaja4(display_short)|uniprotkb:MmDjA4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_067397.1|ensembl:ENSMUSG00000032285(gene)|ensembl:ENSMUST00000070070(transcript)|ensembl:ENSMUST00000120452(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q9JMC3|reactome:R-MMU-3371497	-	-	comment:mint	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:7FqDLuIp6x/bjGDitvBgdgdXEDw10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P68254	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q80XP9	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-16718881|ensembl:ENSMUSP00000139037|uniprotkb:H6WJI2|uniprotkb:H6WJI3	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:wnk3_mouse(display_long)|uniprotkb:Protein kinase lysine-deficient 3(gene name synonym)|uniprotkb:Protein kinase with no lysine 3(gene name synonym)|uniprotkb:Wnk3(gene name)|psi-mi:Wnk3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|reactome:R-MMU-2672351|go:"GO:0005829"(cytosol)|ensembl:ENSMUSG00000041245(gene)|ensembl:ENSMUST00000184392(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|refseq:NP_001258607.1|refseq:NP_001258608.1|refseq:XP_006528933.1|refseq:XP_006528934.1|refseq:XP_006528935.1|refseq:XP_006528936.1|refseq:XP_006528937.1|refseq:XP_011246131.1|refseq:XP_011246132.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:hsiN9eICdGaExx9UEfxBrCbJssk10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q3UH66	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-16718850|uniprotkb:Q3V387|uniprotkb:Q6PAN9|uniprotkb:Q6ZPI6|uniprotkb:Q7TNS1|uniprotkb:Q811F2	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:wnk2_mouse(display_long)|uniprotkb:Protein kinase lysine-deficient 2(gene name synonym)|uniprotkb:Protein kinase with no lysine 2(gene name synonym)|uniprotkb:Wnk2(gene name)|psi-mi:Wnk2(display_short)|uniprotkb:Kiaa1760(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	reactome:R-MMU-2672351|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|refseq:NP_001277240.1|refseq:NP_001277242.1|refseq:NP_083637.2|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:XZP3MNd8Qw5pnZbyCSN4bKg5GBA10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P70398	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-2214043|uniprotkb:E9QLY0|uniprotkb:Q62497	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:usp9x_mouse(display_long)|uniprotkb:Ubiquitin thioesterase FAF-X(gene name synonym)|uniprotkb:Usp9x(gene name)|psi-mi:Usp9x(display_short)|uniprotkb:Fafl(gene name synonym)|uniprotkb:Fam(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-X(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-X(gene name synonym)|uniprotkb:Fat facets protein-related, X-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, X chromosome(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase FAM(gene name synonym)|uniprotkb:Fat facets homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	interpro:IPR016024(Armadillo-type fold)|interpro:IPR028889|refseq:NP_033507.2|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:P70398|interpro:IPR038765|interpro:IPR021905|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021698"(cerebellar cortex structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0030426"(growth cone)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045177"(apical part of cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|reactome:R-MMU-2173795|reactome:R-MMU-5689880|reactome:R-MMU-8866652|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-9033241	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:QXx5gkd+PxoNgIj2b2dLjpCuNr410090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:O88196	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-310028|uniprotkb:Q05D15|uniprotkb:Q3TMM9|uniprotkb:Q3TPC8|uniprotkb:Q3TPV5|uniprotkb:Q3TQL0|uniprotkb:Q3TSK0|uniprotkb:Q3UFH5|uniprotkb:Q5DTM5|uniprotkb:Q6PG61|uniprotkb:Q8BPM4|uniprotkb:Q8C2N6	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:ttc3_mouse(display_long)|uniprotkb:Ttc3(gene name)|psi-mi:Ttc3(display_short)|uniprotkb:Kiaa4119(gene name synonym)|uniprotkb:TPR repeat protein D(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TTC3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010771"(negative regulation of cell morphogenesis involved in differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR011029(DEATH-like)|interpro:IPR043866	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:c0v6smzObgNddoQsFT81OB1Fe6Q10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q62318	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-346909|uniprotkb:P70391|uniprotkb:Q8C283|uniprotkb:Q99PN4|ensembl:ENSMUSP00000005705	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:tif1b_mouse(display_long)|uniprotkb:Trim28(gene name)|psi-mi:Trim28(display_short)|uniprotkb:Krip1(gene name synonym)|uniprotkb:Tif1b(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:KRAB-A-interacting protein(gene name synonym)|uniprotkb:KRIP-1(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:Kap1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_035718.2|dip:DIP-31477N|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q62318|rcsb pdb:6O5K|reactome:R-MMU-212436|ensembl:ENSMUSG00000005566(gene)|ensembl:ENSMUST00000005705(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:DvGJxQNohVWs++QEAyrqe4ngcz810090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P70399	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-769130|uniprotkb:Q68FD0|uniprotkb:Q8CI97|uniprotkb:Q91YC9|intact:EBI-11051502|intact:EBI-11516626|uniprotkb:A2AU89|uniprotkb:A2AU91|ensembl:ENSMUSP00000106278	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:tp53b_mouse(display_long)|uniprotkb:Tp53bp1(gene name)|psi-mi:Tp53bp1(display_short)|uniprotkb:Trp53bp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001277759.1|refseq:NP_038763.3|dip:DIP-31595N|refseq:XP_011237883.1|ensembl:ENSMUSG00000043909(gene)|ensembl:ENSMUST00000110648(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:P70399|rcsb pdb:1SSF|reactome:R-MMU-3232118|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:z5tOHbR6ApNZRL9aptim/xRaVo010090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q6PFX9	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-11025784|uniprotkb:Q8BX62|ensembl:ENSMUSP00000033929	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:tnks1_mouse(display_long)|uniprotkb:Tnks(gene name)|psi-mi:Tnks(display_short)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 1(gene name synonym)|uniprotkb:Tnks1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_780300.2|ensembl:ENSMUSG00000031529(gene)|ensembl:ENSMUST00000033929(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:Q6PFX9|rcsb pdb:3UTM|rcsb pdb:4N4T|rcsb pdb:5HKP|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-5689880|reactome:R-MMU-8948751|rcsb pdb:6CF6|dip:DIP-61463N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:0iTld3A3m3MICMz4QGogB1kk7iA10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q99KF1	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-12603418|ensembl:ENSMUSP00000105531|uniprotkb:Q9CX02	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:tmed9_mouse(display_long)|uniprotkb:Tmed9(gene name)|psi-mi:Tmed9(display_short)|uniprotkb:Gp25l2(gene name synonym)|uniprotkb:Glycoprotein 25L2(gene name synonym)|uniprotkb:p24 family protein alpha-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000058569(gene)|ensembl:ENSMUST00000109905(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0048205"(COPI coating of Golgi vesicle)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|reactome:R-MMU-6807878|reactome:R-MMU-6811434|refseq:NP_080487.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:8GhpwiVxcXQEEYfeDFAoC4qmpKI10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9WTS5	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-16734841|uniprotkb:Q5NBW7|uniprotkb:Q5NBW8|uniprotkb:Q80TJ0|uniprotkb:Q9JLC0|uniprotkb:Q9QYZ1	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:ten2_mouse(display_long)|uniprotkb:Protein Odd Oz/ten-m homolog 2(gene name synonym)|uniprotkb:Tenascin-M2(gene name synonym)|uniprotkb:Teneurin transmembrane protein 2(gene name synonym)|uniprotkb:Tenm2(gene name)|psi-mi:Tenm2(display_short)|uniprotkb:Kiaa1127(gene name synonym)|uniprotkb:Odz2(gene name synonym)|uniprotkb:Tnm2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0016605"(PML body)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048666"(neuron development)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR008969(Carboxypeptidase-like, regulatory region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR022385|interpro:IPR027689|interpro:IPR009471(Teneurin intracellular, N-terminal)|interpro:IPR028916|interpro:IPR006530(YD repeat)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:wQ0xOO0bqzQ0E++dsnlaGkXJyis10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q6NZL0	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-776265|uniprotkb:Q8BLM2|uniprotkb:Q9CSN3|uniprotkb:Q9CU45|ensembl:ENSMUSP00000090293	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:soga3_mouse(display_long)|uniprotkb:Soga3(gene name)|psi-mi:Soga3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_080414.2|ensembl:ENSMUSG00000038916(gene)|ensembl:ENSMUST00000092629(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|interpro:IPR027881	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:fqFLavYLqmaqDCGT+/GaB6l9h9U10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q8CG48	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-643436|uniprotkb:Q52KE9|uniprotkb:Q61076|uniprotkb:Q9CS17|uniprotkb:Q9CSD8|ensembl:ENSMUSP00000099979|ensembl:ENSMUSP00000113940	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:smc2_mouse(display_long)|uniprotkb:Chromosome-associated protein E(gene name synonym)|uniprotkb:XCAP-E homolog(gene name synonym)|uniprotkb:FGF-inducible protein 16(gene name synonym)|uniprotkb:Smc2(gene name)|psi-mi:Smc2(display_short)|uniprotkb:Cape(gene name synonym)|uniprotkb:Fin16(gene name synonym)|uniprotkb:Smc2l1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_032043.3|refseq:NP_001288341.1|ensembl:ENSMUSG00000028312(gene)|ensembl:ENSMUST00000102915(transcript)|ensembl:ENSMUST00000117280(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027120|interpro:IPR027417|interpro:IPR036277|mint:Q8CG48|rcsb pdb:3L51|reactome:R-MMU-2299718|reactome:R-MMU-2514853	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:A8IwiTQIuTw7BA9PQ5ZTSmxFIQA10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q8VIJ6	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-6094576|uniprotkb:A2A7U6|uniprotkb:Q9ERW2|ensembl:ENSMUSP00000030623	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:sfpq_mouse(display_long)|uniprotkb:Sfpq(gene name)|psi-mi:Sfpq(display_short)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:Psf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_076092.1|ensembl:ENSMUSG00000028820(gene)|ensembl:ENSMUST00000030623(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:Q8VIJ6|reactome:R-MMU-8849468	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:9mciNgfKrEvyAv7kjs55FHlUtRY10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q80UK0	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-646282|uniprotkb:Q3TLJ1|uniprotkb:Q810W3|uniprotkb:Q8CI09|ensembl:ENSMUSP00000099720|ensembl:ENSMUSP00000099721	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:sesd1_mouse(display_long)|uniprotkb:Sestd1(gene name)|psi-mi:Sestd1(display_short)|uniprotkb:Huntingtin-interacting protein-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_780674.1|refseq:XP_006499263.1|refseq:XP_006499264.1|refseq:XP_006499265.1|ensembl:ENSMUSG00000042272(gene)|ensembl:ENSMUST00000102659(transcript)|ensembl:ENSMUST00000102660(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:6vT+co7M/u3no7+pSYJLpvahLEA10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q80U72	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-1766028|uniprotkb:Q6P5H7|uniprotkb:Q7TPH8|uniprotkb:Q80VB1|uniprotkb:Q8CI48|uniprotkb:Q8VII1|uniprotkb:Q922S3|ensembl:ENSMUSP00000068056	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:scrib_mouse(display_long)|uniprotkb:Scrib(gene name)|psi-mi:Scrib(display_short)|uniprotkb:Kiaa0147(gene name synonym)|uniprotkb:Lap4(gene name synonym)|uniprotkb:Scrib1(gene name synonym)|uniprotkb:Protein LAP4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_598850.1|refseq:XP_017171844.1|refseq:NP_001297471.1|refseq:NP_001297472.1|dip:DIP-40660N|ensembl:ENSMUSG00000022568(gene)|ensembl:ENSMUST00000063747(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001843"(neural tube closure)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0008104"(protein localization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016477"(cell migration)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036034|mint:Q80U72|reactome:R-MMU-9013148|reactome:R-MMU-9013406|reactome:R-MMU-9696264|reactome:R-MMU-9696270	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:WF4b5QAjIGIgq6tnexNZtDhI7gk10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q8K4Q0	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-4567273|uniprotkb:Q8C9W9|uniprotkb:Q8CBY4|uniprotkb:Q8CDY8|uniprotkb:Q9D4H3	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:rptor_mouse(display_long)|uniprotkb:Rptor(gene name)|psi-mi:Rptor(display_short)|uniprotkb:Raptor(gene name synonym)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	mint:Q8K4Q0|dip:DIP-46324N|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-3371571|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8943724|reactome:R-MMU-9639288	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:5e8iFGgviuWnhLs/d4+zuYX3bik10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:A0A338P6K9	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-8820921|ensembl:ENSMUSP00000155882|uniprotkb:A2BIE1|uniprotkb:Q3UR75	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:qser1_mouse(display_long)|uniprotkb:Qser1(gene name)|psi-mi:Qser1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000074994(gene)|ensembl:ENSMUST00000231375(transcript)|interpro:IPR025451|mint:A0A338P6K9|refseq:XP_006500521.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:axcsRVyLRD6mBiBbdo5c/Ooj1nU10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:B0V2N1	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-647877|uniprotkb:Q3TEC3|uniprotkb:Q3TXC9|uniprotkb:Q5XJV4|uniprotkb:Q64503|uniprotkb:Q64699|uniprotkb:Q7TT17|uniprotkb:Q4JFC7|ensembl:ENSMUSP00000064048	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:ptprs_mouse(display_long)|uniprotkb:Ptprs(gene name)|psi-mi:Ptprs(display_short)|uniprotkb:Receptor-type tyrosine-protein phosphatase sigma(gene name synonym)|uniprotkb:PTPNU-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_035348.2|refseq:NP_001239382.1|refseq:NP_001239384.1|refseq:NP_001239385.1|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|mint:B0V2N1|rcsb pdb:3SR9|reactome:R-MMU-388844|reactome:R-MMU-8849932|ensembl:ENSMUSG00000013236(gene)|ensembl:ENSMUST00000067538(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008201"(heparin binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021510"(spinal cord development)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:ZHccWWvEOOQcSSD7ic6ow6xeqtU10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q8C015	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-16728624|ensembl:ENSMUSP00000047285|ensembl:ENSMUSP00000076440|uniprotkb:Q3TQJ7|uniprotkb:Q6RWS7	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:pak5_mouse(display_long)|uniprotkb:p21-activated kinase 5(gene name synonym)|uniprotkb:p21-activated kinase 7(gene name synonym)|uniprotkb:Pak5(gene name)|psi-mi:Pak5(display_short)|uniprotkb:Pak7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000039913(gene)|ensembl:ENSMUST00000035264(transcript)|ensembl:ENSMUST00000077200(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028754|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013407|reactome:R-MMU-9013405|refseq:NP_766446.2|refseq:XP_006499572.1|refseq:XP_011237833.1|refseq:XP_017173706.1|refseq:XP_017173707.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:3r3/hAkAlWB3xoa0zEbeVJxDBy010090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q80TM9	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-6908752|ensembl:ENSMUSP00000022469|uniprotkb:Q2YDV7|uniprotkb:Q8C354|uniprotkb:Q8C4X9|uniprotkb:Q8CBH0|uniprotkb:Q91XW6|uniprotkb:Q99LG6|uniprotkb:Q9EPW8|uniprotkb:Q9WUM6	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:nisch_mouse(display_long)|uniprotkb:Nisch(gene name)|psi-mi:Nisch(display_short)|uniprotkb:Kiaa0975(gene name synonym)|uniprotkb:Imidazoline receptor 1(gene name synonym)|uniprotkb:Imidazoline receptor I-1-like protein(gene name synonym)|uniprotkb:Imidazoline-1 receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000021910(gene)|ensembl:ENSMUST00000022469(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048243"(norepinephrine secretion)|go:"GO:0055037"(recycling endosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001683(Phox-like)|interpro:IPR025875|interpro:IPR032675|interpro:IPR036871|interpro:IPR037904|mint:Q80TM9|reactome:R-MMU-9013149|reactome:R-MMU-9696264|reactome:R-MMU-9696270|refseq:NP_073147.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:4WK1HdDSTowpkrUNW9iMr+WB4t010090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P46935	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P55066	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-774845|uniprotkb:Q6P1E3|uniprotkb:Q8C4F8	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:ncan_mouse(display_long)|uniprotkb:Chondroitin sulfate proteoglycan 3(gene name synonym)|uniprotkb:Ncan(gene name)|psi-mi:Ncan(display_short)|uniprotkb:Cspg3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_031815.2|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR018378|interpro:IPR016187(C-type lectin fold)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR000538(Link)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR036179|mint:P55066|go:"GO:0001501"(skeletal system development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007417"(central nervous system development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0045202"(synapse)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0072534"(perineuronal net)|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|reactome:R-MMU-3000178	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:FbEuo7LHWAZLqfPi0o0JVHNX4Y410090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q8K310	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-1216295|ensembl:ENSMUSP00000125761|ensembl:ENSMUSP00000158074|ensembl:ENSMUSP00000158537	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:matr3_mouse(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_034901.2|rcsb pdb:1X4F|rcsb pdb:1X4D|ensembl:ENSMUSG00000037236(gene)|ensembl:ENSMUST00000166793(transcript)|ensembl:ENSMUST00000235199(transcript)|ensembl:ENSMUST00000237744(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:Q8K310	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:AwtFbI+oRfha+mn/v3yzG6bNXYg10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9ER67	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-16731218|ensembl:ENSMUSP00000026302|ensembl:ENSMUSP00000108317|ensembl:ENSMUSP00000108319|ensembl:ENSMUSP00000108320	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:q9er67_mouse(display_long)|uniprotkb:Maged2(gene name)|psi-mi:Maged2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000025268(gene)|ensembl:ENSMUST00000026302(transcript)|ensembl:ENSMUST00000112697(transcript)|ensembl:ENSMUST00000112699(transcript)|ensembl:ENSMUST00000112700(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007565"(female pregnancy)|go:"GO:0070294"(renal sodium ion absorption)|interpro:IPR002190(MAGE protein)|interpro:IPR028810|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-MMU-114608|refseq:NP_001186175.1|refseq:NP_109625.1|refseq:XP_006529060.1|refseq:XP_006529061.1|refseq:XP_006529062.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:+3Z5N6WLUNM2ed7Irzn9DAXL+AU10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9QYH6	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-1801274|uniprotkb:Q543L6|uniprotkb:Q99PB5|uniprotkb:Q9CYX1|ensembl:ENSMUSP00000026142	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:magd1_mouse(display_long)|uniprotkb:Maged1(gene name)|psi-mi:Maged1(display_short)|uniprotkb:Nrage(gene name synonym)|uniprotkb:MAGE-D1 antigen(gene name synonym)|uniprotkb:Neurotrophin receptor-interacting MAGE homolog(gene name synonym)|uniprotkb:Dlxin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_062765.1|interpro:IPR041898|interpro:IPR041899|mint:Q9QYH6|ensembl:ENSMUSG00000025151(gene)|ensembl:ENSMUST00000026142(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR030083|interpro:IPR037445	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:yQjDWQnoyOmw1R+BGkK3EO5blik10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P28738	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-2506834|uniprotkb:Q6NXI9|ensembl:ENSMUSP00000028102|uniprotkb:Q9Z2F8	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:kif5c_mouse(display_long)|uniprotkb:Kif5c(gene name)|psi-mi:Kif5c(display_short)|uniprotkb:Nkhc2(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000026764(gene)|ensembl:ENSMUST00000028102(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051028"(mRNA transport)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098964"(anterograde dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0150034"(distal axon)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:P28738|rcsb pdb:1VFV|rcsb pdb:1VFW|rcsb pdb:1VFX|rcsb pdb:1VFZ|rcsb pdb:3J6H|rcsb pdb:3WRD|rcsb pdb:3X2T|rcsb pdb:5HLE|refseq:NP_032475.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:GbPyKDztqPG8BP2+44k3TXPuI/010090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q6ZQ88	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-1216284|ensembl:ENSMUSP00000111977|uniprotkb:Q6PB53|uniprotkb:Q8VEA1|uniprotkb:A3KG94	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:kdm1a_mouse(display_long)|uniprotkb:Kdm1a(gene name)|psi-mi:Kdm1a(display_short)|uniprotkb:Kiaa0601(gene name synonym)|uniprotkb:Lsd1(gene name synonym)|uniprotkb:Flavin-containing amine oxidase domain-containing protein 2(gene name synonym)|uniprotkb:BRAF35-HDAC complex protein BHC110(gene name synonym)|uniprotkb:Aof2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_598633.2|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032451"(demethylase activity)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032453"(histone H3-methyl-lysine-4 demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0032991"(protein-containing complex)|ensembl:ENSMUSG00000036940(gene)|ensembl:ENSMUST00000116273(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0008134"(transcription factor binding)|dip:DIP-38599N|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0033184"(positive regulation of histone ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034648"("obsolete histone demethylase activity (H3-dimethyl-K4 specific)")|go:"GO:0034649"("obsolete histone demethylase activity (H3-monomethyl-K4 specific)")|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0043426"(MRF binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046098"(guanine metabolic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0055001"(muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061752"(telomeric repeat-containing RNA binding)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1903827"|go:"GO:1990138"(neuron projection extension)|go:"GO:1990391"(DNA repair complex)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR002937(Amine oxidase)|interpro:IPR007526(SWIRM)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017366(Histone lysine-specific demethylase)|interpro:IPR036188|mint:Q6ZQ88|reactome:R-MMU-3214815|reactome:R-MMU-3214842|reactome:R-MMU-5625886|reactome:R-MMU-9018519|reactome:R-MMU-983231|interpro:IPR036388	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:4rlXgUzLs3mhV2FLX207Io9etU010090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q07113	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-2891155|ensembl:ENSMUSP00000024599|uniprotkb:Q61822|uniprotkb:Q6LED1	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:mpri_mouse(display_long)|uniprotkb:Igf2r(gene name)|psi-mi:Igf2r(display_short)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:Q07113|reactome:R-MMU-432722|reactome:R-MMU-6798695|reactome:R-MMU-6811440|reactome:R-MMU-8856825|reactome:R-MMU-8856828|ensembl:ENSMUSG00000023830(gene)|ensembl:ENSMUST00000024599(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001889"(liver development)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|refseq:NP_034645.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:sqdDRrqMg68UCTjHNnqZACflsEs10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P63017	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-433443|uniprotkb:P08109|uniprotkb:P12225|uniprotkb:Q3U6R0|uniprotkb:Q3U764|uniprotkb:Q3U7D7|uniprotkb:Q3U7E2|uniprotkb:Q3U9B4|uniprotkb:Q3U9G0|uniprotkb:Q3UGM0|uniprotkb:Q5FWJ6|uniprotkb:Q62373|uniprotkb:Q62374|uniprotkb:Q62375|uniprotkb:Q6NZD0|ensembl:ENSMUSP00000015800	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:hsp7c_mouse(display_long)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Hspa8(gene name)|psi-mi:Hspa8(display_short)|uniprotkb:Hsc70(gene name synonym)|uniprotkb:Hsc73(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_112442.2|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031686"(A1 adenosine receptor binding)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043531"(ADP binding)|go:"GO:0043624"|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044309"(neuron spine)|go:"GO:0044788"(modulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0030425"(dendrite)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904592"(positive regulation of protein refolding)|go:"GO:1904593"(prostaglandin binding)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005681"(spliceosomal complex)|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-450408|reactome:R-MMU-6798695|reactome:R-MMU-72163|reactome:R-MMU-8856828|reactome:R-MMU-8876725|reactome:R-MMU-888590|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990836"(lysosomal matrix)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P63017|rcsb pdb:3CQX|reactome:R-MMU-3371453|reactome:R-MMU-3371497|ensembl:ENSMUSG00000015656(gene)|ensembl:ENSMUST00000015800(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|dip:DIP-32353N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:WDnUczLfoe3ODQbiEITN3DfQnFA10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P07901	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-78930|ensembl:ENSMUSP00000021698|ensembl:ENSMUSP00000091921	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:hs90a_mouse(display_long)|uniprotkb:Hsp90aa1(gene name)|psi-mi:Hsp90aa1(display_short)|uniprotkb:Hsp86(gene name synonym)|uniprotkb:Hsp86-1(gene name synonym)|uniprotkb:Hspca(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Tumor-specific transplantation 86 kDa antigen(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_034610.1|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045585"(positive regulation of cytotoxic T cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097226"(sperm mitochondrial sheath)|go:"GO:0097524"(sperm plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07901|rcsb pdb:5H22|reactome:R-MMU-1227986|reactome:R-MMU-1474151|reactome:R-MMU-168928|reactome:R-MMU-2029482|reactome:R-MMU-203615|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-3371511|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-399954|reactome:R-MMU-4420097|reactome:R-MMU-5218920|reactome:R-MMU-5620912|reactome:R-MMU-5675482|reactome:R-MMU-6798695|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8863795|reactome:R-MMU-8939211|reactome:R-MMU-9009391|reactome:R-MMU-9013418|reactome:R-MMU-9018519|reactome:R-MMU-9652282|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032564"(dATP binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|ensembl:ENSMUSG00000021270(gene)|ensembl:ENSMUST00000021698(transcript)|ensembl:ENSMUST00000094361(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042026"(protein refolding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|dip:DIP-30975N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:t9XAeXdXezYOtJX0wp3IY9/ZMkQ10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q60987	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-11166131|uniprotkb:Q80VP3|ensembl:ENSMUSP00000021333|ensembl:ENSMUSP00000136372	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:foxg1_mouse(display_long)|uniprotkb:Foxg1(gene name)|psi-mi:Foxg1(display_short)|uniprotkb:Fkhl1(gene name synonym)|uniprotkb:Foxg1b(gene name synonym)|uniprotkb:Hfhbf1(gene name synonym)|uniprotkb:Brain factor 1(gene name synonym)|uniprotkb:Forkhead-related protein FKHL1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001153584.1|refseq:NP_032267.1|ensembl:ENSMUSG00000020950(gene)|ensembl:ENSMUST00000021333(transcript)|ensembl:ENSMUST00000179669(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007568"(aging)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030900"(forebrain development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048664"(neuron fate determination)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|mint:Q60987|reactome:R-MMU-9617828	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:FbF/4ZOITo7F9nUUUXdx+1Khr8Q10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P35922	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-645094	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q8BNE1	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-16734801|uniprotkb:Q6A005|uniprotkb:Q80VG2|uniprotkb:Q8BPR4|uniprotkb:Q8BTD3|uniprotkb:Q8C8Q5|uniprotkb:Q8CEM1|uniprotkb:Q8CET9|uniprotkb:Q8K2D7|uniprotkb:Q9D223	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:tcaf1_mouse(display_long)|uniprotkb:TRP channel-associated factor 1(gene name synonym)|uniprotkb:Tcaf1(gene name)|psi-mi:Tcaf1(display_short)|uniprotkb:Fam115a(gene name synonym)|uniprotkb:Kiaa0738(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901529"(positive regulation of anion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0010359"(regulation of anion channel activity)|interpro:IPR042279|refseq:NP_084206.1|refseq:XP_006506814.1|refseq:XP_006506815.1|refseq:XP_006506816.1|refseq:XP_006506817.1|refseq:XP_006506818.1|refseq:XP_006506819.1|refseq:XP_017177319.1|interpro:IPR029062|interpro:IPR035423|interpro:IPR031161	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:8QlSrceywadQ2X66QD4YRmc7fos10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q03137	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-1539152|uniprotkb:Q80VZ2|ensembl:ENSMUSP00000027451|ensembl:ENSMUSP00000139640|ensembl:ENSMUSP00000140954	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:epha4_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor SEK-1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-3(gene name synonym)|uniprotkb:Epha4(gene name)|psi-mi:Epha4(display_short)|uniprotkb:Sek(gene name synonym)|uniprotkb:Sek1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_031962.2|dip:DIP-1019N|ensembl:ENSMUST00000027451(transcript)|ensembl:ENSMUST00000188797(transcript)|ensembl:ENSMUST00000188952(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016301"(kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|ensembl:ENSMUSG00000026235(gene)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:Q03137|rcsb pdb:1B0X|rcsb pdb:2HEL|rcsb pdb:2I8J|rcsb pdb:2XYU|rcsb pdb:2Y6M|rcsb pdb:2Y6O|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:cDRUcRD/LB5owMEI7vdfcaD90uE10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P10630	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-1634890|uniprotkb:Q61513|uniprotkb:Q61514|ensembl:ENSMUSP00000023599	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:if4a2_mouse(display_long)|uniprotkb:Eif4a2(gene name)|psi-mi:Eif4a2(display_short)|uniprotkb:Ddx2b(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001116509.1|refseq:NP_001116510.1|refseq:NP_038534.2|refseq:NP_001334108.1|ensembl:ENSMUSG00000022884(gene)|ensembl:ENSMUST00000023599(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900260"(negative regulation of RNA-directed 5'-3' RNA polymerase activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044728|mint:P10630|reactome:R-MMU-1169408|reactome:R-MMU-156827|reactome:R-MMU-429947|reactome:R-MMU-72649|reactome:R-MMU-72662|reactome:R-MMU-72702|reactome:R-MMU-72706	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:m9i/jWfsbU+6kQvj1h06x31+awg10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P58252	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-773856|uniprotkb:Q544E4|ensembl:ENSMUSP00000046101	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:ef2_mouse(display_long)|uniprotkb:Eef2(gene name)|psi-mi:Eef2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_031933.1|ensembl:ENSMUSG00000034994(gene)|ensembl:ENSMUST00000047864(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P58252|reactome:R-MMU-156902|reactome:R-MMU-5358493|reactome:R-MMU-6798695	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:910/vo3IRjcncyPD4f43dPtS83o10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q61214	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-80344|ensembl:ENSMUSP00000023614|ensembl:ENSMUSP00000113660	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:dyr1a_mouse(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:MP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000022897(gene)|ensembl:ENSMUST00000023614(transcript)|ensembl:ENSMUST00000119878(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|reactome:R-MMU-1538133|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|refseq:XP_011244396.1|refseq:XP_011244397.1|refseq:NP_001106860.1|refseq:NP_031916.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:UK/KpVs/ghE0Oxjq8KGWBvxAt5s10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q8R1A4	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-776274|uniprotkb:Q45V78|uniprotkb:Q5PRE6|uniprotkb:Q6PJ17|uniprotkb:Q9CSB6|uniprotkb:Q9CXM7	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:dock7_mouse(display_long)|uniprotkb:Gm430(gene name synonym)|uniprotkb:Dock7(gene name)|psi-mi:Dock7(display_short)|uniprotkb:Kiaa1771(gene name synonym)|uniprotkb:Mnlt(gene name synonym)|uniprotkb:Protein moonlight(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	interpro:IPR027357|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR043162|interpro:IPR043161|interpro:IPR026791|interpro:IPR027007|interpro:IPR035892|interpro:IPR037808|mint:Q8R1A4|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043473"(pigmentation)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|reactome:R-MMU-8875555|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-983231	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:T4W30iJF8XaTuK57c9vlJFr9gpg10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:O88809	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-16724620|ensembl:ENSMUSP00000033642|ensembl:ENSMUSP00000084570|uniprotkb:Q6E5A4	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:dcx_mouse(display_long)|uniprotkb:Doublin(gene name synonym)|uniprotkb:Lissencephalin-X(gene name synonym)|uniprotkb:Dcx(gene name)|psi-mi:Dcx(display_short)|uniprotkb:Dcn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000031285(gene)|ensembl:ENSMUST00000033642(transcript)|ensembl:ENSMUST00000087313(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0035082"(axoneme assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060041"(retina development in camera-type eye)|interpro:IPR003533(Doublecortin)|interpro:IPR017302(Neuronal migration protein doublecortin)|interpro:IPR036572|interpro:IPR040163|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|refseq:NP_001103692.1|refseq:NP_001103693.1|refseq:NP_001103694.1|refseq:NP_034155.2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:bZVdhkO518ZmQJpBRfIqaTPon1Y10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q80TV8	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-908322|uniprotkb:Q505G6|uniprotkb:Q6DI75|uniprotkb:Q6PG14|uniprotkb:Q8BNS4|uniprotkb:Q99JH5|uniprotkb:Q99JI2|uniprotkb:Q9CVU1	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:clap1_mouse(display_long)|uniprotkb:Clasp1(gene name)|psi-mi:Clasp1(display_short)|uniprotkb:Cytoplasmic linker-associated protein 1(gene name synonym)|uniprotkb:Kiaa0622(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001280229.1|refseq:NP_001280230.1|refseq:NP_083985.2|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024395|interpro:IPR021133|interpro:IPR028399|interpro:IPR034085|mint:Q80TV8|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0006903"(vesicle targeting)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0030981"(cortical microtubule cytoskeleton)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031592"(centrosomal corona)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0043515"(kinetochore binding)|go:"GO:0045180"(basal cortex)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-2500257	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:HwJCOu/w9CSWzqLB7WEjrC4a3bg10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P42932	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-772400|ensembl:ENSMUSP00000026704	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:tcpq_mouse(display_long)|uniprotkb:CCT-theta(gene name synonym)|uniprotkb:Cct8(gene name)|psi-mi:Cct8(display_short)|uniprotkb:Cctq(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_033970.3|ensembl:ENSMUSG00000025613(gene)|ensembl:ENSMUST00000026704(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012721(T-complex protein 1, theta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P42932|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6798695|reactome:R-MMU-6814122	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:p3GMjguKvbAdbh4NkDyU8W4nr1E10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P80318	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-772361|ensembl:ENSMUSP00000001452	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:tcpg_mouse(display_long)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:Matricin(gene name synonym)|uniprotkb:mTRiC-P5(gene name synonym)|uniprotkb:Cct3(gene name)|psi-mi:Cct3(display_short)|uniprotkb:Cctg(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_033966.1|dip:DIP-32344N|ensembl:ENSMUSG00000001416(gene)|ensembl:ENSMUST00000001452(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P80318|rcsb pdb:1GML|rcsb pdb:1GN1|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6814122	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:+jrWcoDzrkHivHA/h3aApt0gBFU10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:B2RQC6	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-3043834|ensembl:ENSMUSP00000013773|uniprotkb:B7ZN27	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:pyr1_mouse(display_long)|uniprotkb:Cad(gene name)|psi-mi:Cad(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000013629(gene)|ensembl:ENSMUST00000013773(transcript)|go:"GO:0002134"(UTP binding)|go:"GO:0004070"(aspartate carbamoyltransferase activity)|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004151"(dihydroorotase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014075"(response to amine)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016597"(amino acid binding)|go:"GO:0017144"|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0001889"(liver development)|go:"GO:0031000"(response to caffeine)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044205"('de novo' UMP biosynthetic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051414"(response to cortisol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR002082(Aspartate carbamoyltransferase, eukaryotic)|interpro:IPR002195(Dihydroorotase, conserved site)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|go:"GO:0019899"(enzyme binding)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR032466|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036901|interpro:IPR036914|mint:B2RQC6|reactome:R-MMU-500753|refseq:NP_076014.1|refseq:NP_001276451.1|dip:DIP-61412N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:t+qQw7me78vEm/Y4VBBhS8fmCsY10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:F6SEU4	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-5797569|ensembl:ENSMUSP00000141686	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q4ACU6	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P63328	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-397208|uniprotkb:P12816|uniprotkb:P20652|uniprotkb:Q3UCU1|uniprotkb:Q64135|ensembl:ENSMUSP00000053101	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:pp2ba_mouse(display_long)|uniprotkb:Ppp3ca(gene name)|psi-mi:Ppp3ca(display_short)|uniprotkb:Calna(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_032939.1|refseq:NP_001280551.1|ensembl:ENSMUSG00000028161(gene)|ensembl:ENSMUST00000056758(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042383"(sarcolemma)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P63328|rcsb pdb:4ORB|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|dip:DIP-31543N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:98yAyDGZZxKYOv22ejceyfJbvao10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P28660	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9JM52	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-645434|uniprotkb:Q5SXG2|uniprotkb:Q921M6|uniprotkb:Q9JM92|ensembl:ENSMUSP00000099619	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:mink1_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase kinase kinase kinase 6(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 6(gene name synonym)|uniprotkb:Misshapen/NIK-related kinase(gene name synonym)|uniprotkb:GCK family kinase MiNK(gene name synonym)|uniprotkb:Mink1(gene name)|psi-mi:Mink1(display_short)|uniprotkb:Map4k6(gene name synonym)|uniprotkb:Mink(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_795712.2|refseq:XP_006533744.1|refseq:NP_057922.2|ensembl:ENSMUSG00000020827(gene)|ensembl:ENSMUST00000102559(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007275"(multicellular organism development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000311"(regulation of AMPA receptor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9JM52|reactome:R-MMU-2559580	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:Kuk8yQcHbIShH9SwsEkvyMTVcMw10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q62108	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q7TMB8	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q923T9	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-771638|uniprotkb:Q3U3H3|uniprotkb:Q8VED3|ensembl:ENSMUSP00000071720	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:kcc2g_mouse(display_long)|uniprotkb:Camk2g(gene name)|psi-mi:Camk2g(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001034227.1|refseq:NP_001034228.1|refseq:NP_848712.2|ensembl:ENSMUSG00000021820(gene)|ensembl:ENSMUST00000071816(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q923T9|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:pbJqcEUQJQRnAwcKozmS72n9s1w10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q6PHZ2	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-2308458|uniprotkb:Q3UF87|uniprotkb:Q3UQH9|uniprotkb:Q5DTK4|uniprotkb:Q8CAC5|uniprotkb:Q9CZE2|ensembl:ENSMUSP00000143504	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:kcc2d_mouse(display_long)|uniprotkb:Camk2d(gene name)|psi-mi:Camk2d(display_short)|uniprotkb:Kiaa4163(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001020609.1|refseq:NP_076302.1|refseq:NP_001020610.1|refseq:NP_001280592.1|refseq:NP_001280593.1|dip:DIP-47638N|ensembl:ENSMUSG00000053819(gene)|ensembl:ENSMUST00000199300(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031432"(titin binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q6PHZ2|rcsb pdb:6BAB|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:z2mz73Kq9gwpKgo2Todn0IxQpSI10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P28652	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q60875	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-772191|uniprotkb:E9QNW9|uniprotkb:O09115|uniprotkb:Q3TBI4|uniprotkb:Q3TJ16|uniprotkb:Q8CHE1|uniprotkb:Q923E0|uniprotkb:Q9ESG7|ensembl:ENSMUSP00000029694	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:arhg2_mouse(display_long)|uniprotkb:Kiaa0651(gene name synonym)|uniprotkb:Lbcl1(gene name synonym)|uniprotkb:Lfc(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Lymphoid blast crisis-like 1(gene name synonym)|uniprotkb:LBC'S first cousin(gene name synonym)|uniprotkb:Oncogene LFC(gene name synonym)|uniprotkb:Rhobin(gene name synonym)|uniprotkb:Arhgef2(gene name)|psi-mi:Arhgef2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001185840.1|refseq:NP_001185841.1|refseq:NP_001185842.1|refseq:NP_032513.3|refseq:XP_006501130.1|ensembl:ENSMUSG00000028059(gene)|ensembl:ENSMUST00000029694(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002102"(podosome)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071802"(negative regulation of podosome assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037806|interpro:IPR041020|mint:Q60875|rcsb pdb:5WI4|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:Le4PMm1AT/ManVpetNT2wBsUlok10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q8K3H0	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-400377|uniprotkb:Q3UJP7|uniprotkb:Q69ZJ9|uniprotkb:Q8BWZ8|uniprotkb:Q8VCJ8|uniprotkb:Q9CUW4|ensembl:ENSMUSP00000042875	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:dp13a_mouse(display_long)|uniprotkb:Appl1(gene name)|psi-mi:Appl1(display_short)|uniprotkb:Dip13a(gene name synonym)|uniprotkb:Kiaa1428(gene name synonym)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_660256.1|ensembl:ENSMUSG00000040760(gene)|ensembl:ENSMUST00000036570(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|interpro:IPR037929|mint:Q8K3H0|reactome:R-MMU-418889	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:1ZML/W0Qi+jMAeZQ7PXfiHA6YBE10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q8CBW3	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P63101	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q8R5H6	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-774719|uniprotkb:Q91W51|uniprotkb:Q9ERQ9|ensembl:ENSMUSP00000019975|ensembl:ENSMUSP00000101148	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:wasf1_mouse(display_long)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Wasf1(gene name)|psi-mi:Wasf1(display_short)|uniprotkb:Wave1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_114083.1|refseq:XP_006512995.1|ensembl:ENSMUSG00000019831(gene)|ensembl:ENSMUST00000019975(transcript)|ensembl:ENSMUST00000105509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8R5H6|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013423	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:t+4F2ap7lNjE/AGuIwMhel4YknU10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9R1R2	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-775991|uniprotkb:Q3UMU5|ensembl:ENSMUSP00000053384|ensembl:ENSMUSP00000102401|ensembl:ENSMUSP00000114822	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:trim3_mouse(display_long)|uniprotkb:RING finger protein 22(gene name synonym)|uniprotkb:RING finger protein HAC1(gene name synonym)|uniprotkb:Trim3(gene name)|psi-mi:Trim3(display_short)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Rnf22(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001272799.1|refseq:NP_001272800.1|refseq:NP_001272802.1|refseq:NP_061368.1|ensembl:ENSMUSG00000036989(gene)|ensembl:ENSMUST00000057525(transcript)|ensembl:ENSMUST00000106789(transcript)|ensembl:ENSMUST00000147044(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001258(NHL repeat)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR017907|interpro:IPR027370|mint:Q9R1R2	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:fOQH1BPgmOXrJXOb8VYYFpNX0UQ10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q8BYI9	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-774167|uniprotkb:A2RT70|uniprotkb:O88717|ensembl:ENSMUSP00000107298|ensembl:ENSMUSP00000141553	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:tenr_mouse(display_long)|uniprotkb:Restrictin(gene name synonym)|uniprotkb:Janusin(gene name synonym)|uniprotkb:Neural recognition molecule J1-160/180(gene name synonym)|uniprotkb:Tnr(gene name)|psi-mi:Tnr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_071707.2|refseq:XP_006496805.1|refseq:XP_006496806.1|refseq:XP_006496807.1|ensembl:ENSMUSG00000015829(gene)|ensembl:ENSMUST00000111669(transcript)|ensembl:ENSMUST00000192069(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0045121"(membrane raft)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048692"(negative regulation of axon extension involved in regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072534"(perineuronal net)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098966"(perisynaptic extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR033079|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:Q8BYI9|reactome:R-MMU-3000178	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:K7s7yPGS4RvIe+thCkAZIFGjNRA10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9D0K0	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-11157369|ensembl:ENSMUSP00000021797|ensembl:ENSMUSP00000137280|uniprotkb:Q3U0V0|uniprotkb:Q05AE0|uniprotkb:B7ZNC1	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:tbcd7_mouse(display_long)|uniprotkb:Tbc1d7(gene name)|psi-mi:Tbc1d7(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001239568.1|refseq:NP_001239569.1|refseq:NP_080211.1|ensembl:ENSMUSG00000021368(gene)|ensembl:ENSMUST00000021797(transcript)|ensembl:ENSMUST00000179852(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0070848"(response to growth factor)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|interpro:IPR039842|interpro:IPR043039|reactome:R-MMU-8854214	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:VJJoSoRELbJzK+1iJef0zaLl1z010090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q01405	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-775901|ensembl:ENSMUSP00000021375|uniprotkb:Q8JZL4	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:sc23a_mouse(display_long)|uniprotkb:SEC23-related protein A(gene name synonym)|uniprotkb:Sec23a(gene name)|psi-mi:Sec23a(display_short)|uniprotkb:Sec23(gene name synonym)|uniprotkb:Sec23r(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000020986(gene)|ensembl:ENSMUST00000021375(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR007123(Gelsolin region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|refseq:NP_033173.2|refseq:XP_006515691.1|dip:DIP-32032N|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR037364|interpro:IPR037550|mint:Q01405|reactome:R-MMU-204005|reactome:R-MMU-2132295|reactome:R-MMU-5694530|reactome:R-MMU-983170	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:0aSRfr1sJuL/w805EjjbO4tw/Hg10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9Z268	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-2013210|uniprotkb:Q99K69|ensembl:ENSMUSP00000031606|ensembl:ENSMUSP00000123266	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:rasl1_mouse(display_long)|uniprotkb:Rasal1(gene name)|psi-mi:Rasal1(display_short)|uniprotkb:Rasal(gene name synonym)|uniprotkb:RAS protein activator like 1(gene name synonym)|uniprotkb:Ras GTPase-activating-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:XP_006530272.1|refseq:XP_006530273.1|refseq:NP_038860.2|ensembl:ENSMUSG00000029602(gene)|ensembl:ENSMUST00000031606(transcript)|ensembl:ENSMUST00000156722(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028555|interpro:IPR035892|interpro:IPR037776|interpro:IPR039360|mint:Q9Z268|reactome:R-MMU-5658442	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:VbTtsNfJC0uXiZYAtnOIFBPfLkA10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P61226	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-16724536|ensembl:ENSMUSP00000038841|uniprotkb:P17964|uniprotkb:Q96EG5|uniprotkb:Q9CXG0	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:rap2b_mouse(display_long)|uniprotkb:Rap2b(gene name)|psi-mi:Rap2b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000036894(gene)|ensembl:ENSMUST00000049064(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041840|reactome:R-MMU-6798695|refseq:NP_082988.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:dFHHIYuDf3lTGSX0Nys6IE9ONvs10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P62827	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-286564|uniprotkb:Q3U954|uniprotkb:Q811M2|uniprotkb:Q86V08|uniprotkb:P17080|uniprotkb:P28746|uniprotkb:P28747|uniprotkb:Q9UDJ5|uniprotkb:Q9CSP3|uniprotkb:Q9CWI7|uniprotkb:Q9CZA2|uniprotkb:Q9UEU9|ensembl:ENSMUSP00000031383|ensembl:ENSMUSP00000106975	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:ran_mouse(display_long)|uniprotkb:GTPase Ran(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:Ras-like protein TC4(gene name synonym)|uniprotkb:Ran(gene name)|psi-mi:Ran(display_short)|uniprotkb:Rasl2-8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_033417.1|refseq:XP_006504343.1|ensembl:ENSMUSG00000029430(gene)|ensembl:ENSMUST00000031383(transcript)|ensembl:ENSMUST00000111343(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0002177"(manchette)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030496"(midbody)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034629"|go:"GO:0036126"(sperm flagellum)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0061015"(snRNA import into nucleus)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62827|reactome:R-MMU-1655829|reactome:R-MMU-5578749|reactome:R-MMU-9615933	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:trIUv5n3nI5d0rkfDTgw/6ubxMA10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P63001	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q91V41	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-3869482|ensembl:ENSMUSP00000028238	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:rab14_mouse(display_long)|uniprotkb:Rab14(gene name)|psi-mi:Rab14(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_080973.1|ensembl:ENSMUST00000028238(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005795"(Golgi stack)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045176"(apical protein localization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090387"(phagolysosome assembly involved in apoptotic cell clearance)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030702|mint:Q91V41|reactome:R-MMU-1660499|reactome:R-MMU-6798695|reactome:R-MMU-8873719|reactome:R-MMU-8876198|ensembl:ENSMUSG00000026878(gene)	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:qFP8UXDCPt/RcLTWlZLaitH2LF410090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P42669	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-773823|ensembl:ENSMUSP00000059404	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:pura_mouse(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:Pura(gene name)|psi-mi:Pura(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_033015.1|refseq:XP_006525787.1|refseq:XP_011245162.1|ensembl:ENSMUSG00000043991(gene)|ensembl:ENSMUST00000051301(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:P42669	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:3LVZ5qdZYeJyeUVPhy3cozxROWs10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P63318	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-397096|uniprotkb:P05697|ensembl:ENSMUSP00000097874	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:kpcg_mouse(display_long)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_035232.1|ensembl:ENSMUSG00000078816(gene)|ensembl:ENSMUST00000100301(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0005829"(cytosol)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|interpro:IPR020454|interpro:IPR035892|mint:P63318|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-416993|reactome:R-MMU-5099900|reactome:R-MMU-76005	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P68404	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9JIA1	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-445256|ensembl:ENSMUSP00000143128	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:lgi1_mouse(display_long)|uniprotkb:Lgi1(gene name)|psi-mi:Lgi1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_064674.1|ensembl:ENSMUSG00000067242(gene)|ensembl:ENSMUST00000198518(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007411"(axon guidance)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031175"(neuron projection development)|go:"GO:0043083"(synaptic cleft)|go:"GO:0045202"(synapse)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005492(EPTP)|interpro:IPR009039(EAR)|interpro:IPR032675|mint:Q9JIA1|reactome:R-MMU-5682910	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:PEM1comV+IMxsMdEb0dRsl2+pqg10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P32883	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-644267|uniprotkb:P04200|uniprotkb:P08643|ensembl:ENSMUSP00000107339	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:rask_mouse(display_long)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)|uniprotkb:Kras(gene name)|psi-mi:Kras(display_short)|uniprotkb:Kras2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_067259.4|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|go:"GO:0008284"(positive regulation of cell population proliferation)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|reactome:R-MMU-2179392|reactome:R-MMU-2424491|interpro:IPR027417|mint:P32883|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-4086398|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-8951936|reactome:R-MMU-9607240|reactome:R-MMU-9634635|reactome:R-MMU-9648002|reactome:R-MMU-9674555|ensembl:ENSMUSG00000030265(gene)|ensembl:ENSMUST00000111710(transcript)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|refseq:XP_006506981.1|dip:DIP-29362N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:wRpf3zq2kO/Q0QbC/wp+rJNrBlQ10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q61411	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-400273|uniprotkb:Q80WD2|uniprotkb:Q6P716|uniprotkb:Q811B9|ensembl:ENSMUSP00000026572|ensembl:ENSMUSP00000095570|uniprotkb:F7BIB2	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:rash_mouse(display_long)|uniprotkb:Hras(gene name)|psi-mi:Hras(display_short)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:Hras1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:p21ras(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001123915.1|refseq:NP_001123916.1|refseq:NP_032310.2|ensembl:ENSMUSG00000025499(gene)|ensembl:ENSMUST00000026572(transcript)|ensembl:ENSMUST00000097957(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:Q61411|rcsb pdb:6KYH|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|go:"GO:1900029"(positive regulation of ruffle assembly)|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-3928662|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-9607240|reactome:R-MMU-9634635|reactome:R-MMU-9648002|refseq:XP_006536222.2|dip:DIP-29361N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P68040	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-296749|ensembl:ENSMUSP00000020640|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-1183965|uniprotkb:Q3THP0|uniprotkb:Q3THY7|uniprotkb:Q3TKQ0|uniprotkb:Q3TW88|uniprotkb:Q5NCC5|uniprotkb:Q5NCC6|uniprotkb:Q9CSQ0|uniprotkb:Q9ERM6	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:rack1_mouse(display_long)|uniprotkb:p205(gene name synonym)|uniprotkb:Receptor of activated protein kinase C 1(gene name synonym)|uniprotkb:12-3(gene name synonym)|uniprotkb:Gnb2-rs1(gene name synonym)|uniprotkb:Gnb2l1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Rack1(gene name)|psi-mi:Rack1(display_short)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P68040|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|go:"GO:0072344"(rescue of stalled ribosome)|ensembl:ENSMUSG00000020372(gene)|ensembl:ENSMUST00000020640(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008104"(protein localization)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0006412"(translation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044297"(cell body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|refseq:NP_032169.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q6NS60	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-16725383|ensembl:ENSMUSP00000124524|ensembl:ENSMUSP00000124754|ensembl:ENSMUSP00000125671|uniprotkb:Q6P7W4|uniprotkb:Q6ZPG1	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:fbx41_mouse(display_long)|uniprotkb:Fbxo41(gene name)|psi-mi:Fbxo41(display_short)|uniprotkb:D6Ertd538e(gene name synonym)|uniprotkb:Kiaa1940(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000047013(gene)|ensembl:ENSMUST00000159062(transcript)|ensembl:ENSMUST00000161078(transcript)|ensembl:ENSMUST00000161546(transcript)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-MMU-8951664|reactome:R-MMU-983168|refseq:NP_001001160.1|refseq:NP_001276603.1|refseq:NP_001276604.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:MbpGArQonCm6vp3gakR01/4W5Fg10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9QYJ0	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-772431|ensembl:ENSMUSP00000034138	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:dnja2_mouse(display_long)|uniprotkb:Dnaja2(gene name)|psi-mi:Dnaja2(display_short)|uniprotkb:mDj3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_062768.1|ensembl:ENSMUSG00000031701(gene)|ensembl:ENSMUST00000034138(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q9QYJ0|reactome:R-MMU-3371497	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:ZYn3t1WpFrPa82gsMHxjaQRPr3k10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P63037	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-772408|uniprotkb:P54102|ensembl:ENSMUSP00000030118|ensembl:ENSMUSP00000129730	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:dnja1_mouse(display_long)|uniprotkb:Heat shock 40 kDa protein 4(gene name synonym)|uniprotkb:DnaJ protein homolog 2(gene name synonym)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:Dnaja1(gene name)|psi-mi:Dnaja1(display_short)|uniprotkb:Dnaj2(gene name synonym)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Hspf4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001158143.1|refseq:NP_001158144.1|refseq:NP_032324.1|dip:DIP-32350N|ensembl:ENSMUSG00000028410(gene)|ensembl:ENSMUST00000030118(transcript)|ensembl:ENSMUST00000164233(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009408"(response to heat)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:1901998"(toxin transport)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:P63037|reactome:R-MMU-3371497	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:gi42F7LF6CiylXZF4fRg/kuM/s010090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q5SQX6	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q9JLV5	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-2551335|ensembl:ENSMUSP00000130738	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:cul3_mouse(display_long)|uniprotkb:Cul3(gene name)|psi-mi:Cul3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000004364(gene)|ensembl:ENSMUST00000163119(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q9JLV5|rcsb pdb:1IUY|reactome:R-MMU-4641258|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-8932339|reactome:R-MMU-8951664|go:"GO:0030030"(cell projection organization)|reactome:R-MMU-9013418|reactome:R-MMU-9013422|reactome:R-MMU-9706019|reactome:R-MMU-983168|refseq:NP_057925.1|refseq:NP_001300657.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:tSFsLPpnn80evlnxKTXO5olW5Xg10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q02248	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:Q5M8N0	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-16733235|ensembl:ENSMUSP00000050036|uniprotkb:Q3TAC7|uniprotkb:Q3UFR2	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:cnrp1_mouse(display_long)|uniprotkb:Cnrip1(gene name)|psi-mi:Cnrip1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000044629(gene)|ensembl:ENSMUST00000058159(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0031718"(type 1 cannabinoid receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:2000272"(negative regulation of signaling receptor activity)|interpro:IPR029204|mint:Q5M8N0|refseq:NP_084137.1	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:d4VBaXMMjEQ11X2/zohvbiwN3k010090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P49615	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-6510052|ensembl:ENSMUSP00000030814	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:cdk5_mouse(display_long)|uniprotkb:Cdk5(gene name)|psi-mi:Cdk5(display_short)|uniprotkb:Cdkn5(gene name synonym)|uniprotkb:Crk6(gene name synonym)|uniprotkb:CR6 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	ensembl:ENSMUSG00000028969(gene)|ensembl:ENSMUST00000030814(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042220"(response to cocaine)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099533"(positive regulation of presynaptic cytosolic calcium concentration)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49615|reactome:R-MMU-180024|reactome:R-MMU-399956|reactome:R-MMU-6804756|refseq:NP_031694.1|dip:DIP-29353N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:mFzCd7zhLyXpxPDQwc1xXCraDQI10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9EP53	uniprotkb:P11798	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16734894|imex:IM-26285-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	figure legend:Table S1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/12/01	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:Qen5PefAHm9XjJ8+NRK7g+KGiV4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q91XM9	uniprotkb:Q4ACU6	intact:EBI-400138|uniprotkb:Q8BXK7|uniprotkb:Q8BYG5|ensembl:ENSMUSP00000102814|uniprotkb:F8VQM7	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:dlg2_mouse(display_long)|uniprotkb:Dlg2(gene name)|psi-mi:Dlg2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16735282|imex:IM-26285-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000052572(gene)|ensembl:ENSMUST00000107196(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035759|interpro:IPR036028|interpro:IPR036034|mint:Q91XM9|rcsb pdb:2WL7|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6794361|refseq:NP_001229976.1|refseq:NP_035937.2|dip:DIP-31569N	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Figure 7B|comment:this interaction decreases in Tnik-/- mice|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:37/IFbjDNxh87dnN2gglIgDGyIU10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:hpC1mWgQkzx4Q/LNgkOCI62Yon8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8BKX1	uniprotkb:Q4ACU6	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16735272|imex:IM-26285-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0014069"(postsynaptic density)	-	-	comment:interactionMixImport_1516030697686|figure legend:Figure 7B|comment:this interaction decreases in Tnik-/- mice|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:fKiIt7c1oDNP0DQ7N1au/pmhfEI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:F6SEU4	uniprotkb:Q9D415	intact:EBI-5797569|ensembl:ENSMUSP00000141686	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16735242|imex:IM-26285-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Figure 7B|comment:this interaction decreases in Tnik-/- mice|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rigid:S7dZDNyeNGd7JJl4ebXgnZcvKU0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q4ACU6	uniprotkb:Q9D415	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16735202|imex:IM-26285-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Figure 7B|comment:this interaction decreases in Tnik-/- mice|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rigid:qVFwS3OwA1dAePCycXaV2asB3g0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5SQX6	uniprotkb:Q4ACU6	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16735292|imex:IM-26285-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Figure 7B|comment:this interaction decreases in Tnik-/- mice|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:8g7WKTSSdJnGDIKvewBG/9l8/UM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80YA9	uniprotkb:Q9D415	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16735252|imex:IM-26285-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Figure 7B|comment:this interaction decreases in Tnik-/- mice|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rigid:W7Y5hMdMdOS0fF8Sq761vpWJODc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z2Y3	uniprotkb:Q9D415	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16735212|imex:IM-26285-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Figure 7B|comment:this interaction decreases in Shank3deltaC-/+ mice|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rigid:7pF7s+Js+zfQa/tMqYp83dwot04	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9D415	uniprotkb:Q9Z2Y3	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16735222|imex:IM-26285-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Figure 7B|comment:this interaction decreases in Shank3deltaC-/+ mice|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rigid:7pF7s+Js+zfQa/tMqYp83dwot04	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9D415	uniprotkb:Q4ACU6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16735262|imex:IM-26285-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Figure 7B|comment:this interaction decreases in Tnik-/- mice|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:qVFwS3OwA1dAePCycXaV2asB3g0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35436	uniprotkb:Q9D415	intact:EBI-400115|ensembl:ENSMUSP00000032331|ensembl:ENSMUSP00000111501|ensembl:ENSMUSP00000142900	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:nmde1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:Grin2a(gene name)|psi-mi:Grin2a(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16735232|imex:IM-26285-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032196.2|reactome:R-MMU-8849932|reactome:R-MMU-9609736|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-438066|go:"GO:0098839"(postsynaptic density membrane)|ensembl:ENSMUSG00000059003(gene)|ensembl:ENSMUST00000032331(transcript)|ensembl:ENSMUST00000115835(transcript)|ensembl:ENSMUST00000199708(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040011"(locomotion)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|refseq:XP_006521857.1|dip:DIP-31567N	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Figure 7B|comment:this interaction decreases in Tnik-/- mice|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2018/01/16	rogid:5DMFDOh6NuFArDtKp2gp2IpmhWQ10090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rigid:FSq+7CxyhTn0+AB8MjJ2s/M7eks	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62108	uniprotkb:Q6PB66	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-1371262|uniprotkb:Q8K4V0|uniprotkb:Q9CRX4|ensembl:ENSMUSP00000107927	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:lpprc_mouse(display_long)|uniprotkb:Lrpprc(gene name)|psi-mi:Lrpprc(display_short)|uniprotkb:Lrp130(gene name synonym)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_082509.2|ensembl:ENSMUSG00000024120(gene)|ensembl:ENSMUST00000112308(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|reactome:R-MMU-611105|reactome:R-MMU-9707564|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:Q6PB66|reactome:R-MMU-5628897|go:"GO:0005634"(nucleus)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:wNo59nF0OqIHfnoUrxN10z7YIGM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q811P8	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-6949116|ensembl:ENSMUSP00000133898|intact:MINT-268399|uniprotkb:B9EHJ8|uniprotkb:Q6A010	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:rhg32_mouse(display_long)|uniprotkb:RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling(gene name synonym)|uniprotkb:Rics(gene name synonym)|uniprotkb:p200RhoGAP(gene name synonym)|uniprotkb:p250GAP(gene name synonym)|uniprotkb:Arhgap32(gene name)|psi-mi:Arhgap32(display_short)|uniprotkb:Brain-specific Rho GTPase-activating protein(gene name synonym)|uniprotkb:GAB-associated Cdc42/Rac GTPase-activating protein(gene name synonym)|uniprotkb:GC-GAP(gene name synonym)|uniprotkb:Grit(gene name synonym)|uniprotkb:Kiaa0712(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 32(gene name synonym)|uniprotkb:Rho/Cdc42/Rac GTPase-activating protein RICS(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000041444(gene)|ensembl:ENSMUST00000174641(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001650"(fibrillar center)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005938"(cell cortex)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0043197"(dendritic spine)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036028|interpro:IPR036871|interpro:IPR042139|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-9035034|refseq:NP_796353.3|refseq:NP_001182561.1	go:"GO:0014069"(postsynaptic density)	-	comment:mint	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:4ZVZeciVms1xmC18riIhaDt9wMY10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q3UTJ2	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-8345744|uniprotkb:Q80TS1|intact:MINT-1853612|uniprotkb:Q3USC6|uniprotkb:Q8BX47|uniprotkb:Q8CHU0|uniprotkb:Q8BLW9|intact:MINT-4116161|uniprotkb:Q8BJL6|uniprotkb:Q8BJU3	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:srbs2_mouse(display_long)|uniprotkb:Sorbs2(gene name)|psi-mi:Sorbs2(display_short)|uniprotkb:Arg/Abl-interacting protein 2(gene name synonym)|uniprotkb:Argbp2(gene name synonym)|uniprotkb:Kiaa0777(gene name synonym)|uniprotkb:Arg-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001297636.1|interpro:IPR003127(Sorbin-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR028506|interpro:IPR036028|mint:Q3UTJ2|refseq:XP_006509449.1|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR001452(Src homology-3)	go:"GO:0014069"(postsynaptic density)	-	comment:"fragmentation type: fragment"	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:2sKDQux/2IV7mW8l6LK36D3qlqw10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P84084	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-7569461|uniprotkb:P26437|intact:UNK-5383724|uniprotkb:A2RTC5|ensembl:ENSMUSP00000020717|ensembl:ENSMUSP00000127281	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:arf5_mouse(display_long)|uniprotkb:Arf5(gene name)|psi-mi:Arf5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_031506.1|ensembl:ENSMUSG00000020440(gene)|ensembl:ENSMUST00000020717(transcript)|ensembl:ENSMUST00000169841(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|reactome:R-MMU-6807878|reactome:R-MMU-6811434	go:"GO:0014069"(postsynaptic density)	-	function:GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus|comment:mint|comment:homomint	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:da8exbGR3MGxZ6CPZqLvqJbyUYI10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8CFI0	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-8046183|uniprotkb:Q8BS42|uniprotkb:Q8BRT9|intact:MINT-5097552|uniprotkb:Q99PK2	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ned4l_mouse(display_long)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:Nedd4l(gene name)|psi-mi:Nedd4l(display_short)|uniprotkb:Kiaa0439(gene name synonym)|uniprotkb:Nedd4b(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	dip:DIP-48843N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0009651"(response to salt stress)|go:"GO:0010038"(response to metal ion)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:1WR3|rcsb pdb:1WR4|rcsb pdb:1WR7|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-MMU-2173795|reactome:R-MMU-2672351|reactome:R-MMU-983168	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:rne2aA4b/xoATCErEBuu9uK3Zxk10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P61963	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-8318793|uniprotkb:Q9DAE4|uniprotkb:Q3TMV9|uniprotkb:O15491|intact:MINT-4428227|ensembl:ENSMUSP00000058168	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dcaf7_mouse(display_long)|uniprotkb:Dcaf7(gene name)|psi-mi:Dcaf7(display_short)|uniprotkb:Han11(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:Wdr68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_082222.1|ensembl:ENSMUSG00000049354(gene)|ensembl:ENSMUST00000058438(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61963|reactome:R-MMU-8951664	go:"GO:0014069"(postsynaptic density)	-	comment:mint	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P62715	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-8028975|uniprotkb:P11082|intact:UNK-5382027|ensembl:ENSMUSP00000009774	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:pp2ab_mouse(display_long)|uniprotkb:Ppp2cb(gene name)|psi-mi:Ppp2cb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_059070.1|ensembl:ENSMUSG00000009630(gene)|ensembl:ENSMUST00000009774(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P62715|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-9648025	go:"GO:0014069"(postsynaptic density)	-	function:PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase|comment:mint|comment:homomint	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P63101	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q6ZWQ0	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-11517168|uniprotkb:Q640M5|ensembl:ENSMUSP00000047697	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:syne2_mouse(display_long)|uniprotkb:Nuclear envelope spectrin repeat protein 2(gene name synonym)|uniprotkb:Nucleus and actin connecting element protein(gene name synonym)|uniprotkb:Synaptic nuclear envelope protein 2(gene name synonym)|uniprotkb:KASH domain-containing protein 2(gene name synonym)|uniprotkb:Syne2(gene name)|psi-mi:Syne2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	dip:DIP-61049N|refseq:NP_001005510.2|ensembl:ENSMUSG00000063450(gene)|ensembl:ENSMUST00000044217(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0005739"(mitochondrion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031981"(nuclear lumen)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0007097"(nuclear migration)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051642"(centrosome localization)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR012315(Klarsicht/ANC-1/syne-1 homology)|interpro:IPR018159|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|interpro:IPR030266|interpro:IPR036872|mint:Q6ZWQ0	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:dByvgsaISSaQdpGCQahK7a5mG2w10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q62417	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2365368|uniprotkb:Q80TF8|uniprotkb:Q8BZI3|uniprotkb:Q8K3Y2|uniprotkb:Q921F8|uniprotkb:Q9Z0Z8|uniprotkb:Q9Z0Z9	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:srbs1_mouse(display_long)|uniprotkb:Sorbs1(gene name)|psi-mi:Sorbs1(display_short)|uniprotkb:Kiaa1296(gene name synonym)|uniprotkb:Sh3d5(gene name synonym)|uniprotkb:Ponsin(gene name synonym)|uniprotkb:c-Cbl-associated protein(gene name synonym)|uniprotkb:SH3 domain protein 5(gene name synonym)|uniprotkb:SH3P12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001030134.1|refseq:NP_001030135.1|refseq:NP_001030136.1|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|interpro:IPR035606|interpro:IPR035610|interpro:IPR035611|interpro:IPR036028|mint:Q62417|go:"GO:0001725"(stress fiber)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016600"(flotillin complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|reactome:R-MMU-445355	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:3+0ZfSkNB+9ujOF3uyXmP2ovl8A10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P19246	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-1634658|uniprotkb:A1E2H9|uniprotkb:Q5SVF6|uniprotkb:Q61959|ensembl:ENSMUSP00000091061	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:nfh_mouse(display_long)|uniprotkb:Nefh(gene name)|psi-mi:Nefh(display_short)|uniprotkb:Kiaa0845(gene name synonym)|uniprotkb:Nfh(gene name synonym)|uniprotkb:Neurofilament triplet H protein(gene name synonym)|uniprotkb:200 kDa neurofilament protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_035034.2|ensembl:ENSMUSG00000020396(gene)|ensembl:ENSMUST00000093369(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001552"(ovarian follicle atresia)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0007420"(brain development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015643"(toxic substance binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031103"(axon regeneration)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0061564"(axon development)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:0150017"(basal proximal dendrite)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR010790(Protein of unknown function DUF1388)|interpro:IPR018039|interpro:IPR033183|interpro:IPR039008|mint:P19246	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:1Fs10v+/s87EA3iRKeuxNEijJ5o10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P33175	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-349710|uniprotkb:Q5DTP1|uniprotkb:Q6PDY7|uniprotkb:Q9Z2F9|ensembl:ENSMUSP00000096775|ensembl:ENSMUSP00000151402	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kif5a_mouse(display_long)|uniprotkb:Kif5a(gene name)|psi-mi:Kif5a(display_short)|uniprotkb:Kiaa4086(gene name synonym)|uniprotkb:Kif5(gene name synonym)|uniprotkb:Neuronal kinesin heavy chain(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 1(gene name synonym)|uniprotkb:Nkhc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001034089.1|refseq:NP_032473.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P33175|reactome:R-MMU-2132295|reactome:R-MMU-5625970|reactome:R-MMU-6811434|reactome:R-MMU-983189|ensembl:ENSMUSG00000074657(gene)|ensembl:ENSMUST00000099172(transcript)|ensembl:ENSMUST00000217895(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:otK0LxjRwOuSLqL6iOEI+7BY+SI10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:O88335	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-295404|ensembl:ENSMUSP00000046793|ensembl:ENSMUSP00000150540	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kcnj1_mouse(display_long)|uniprotkb:Kcnj1(gene name)|psi-mi:Kcnj1(display_short)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 1(gene name synonym)|uniprotkb:ATP-regulated potassium channel ROM-K(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir1.1"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_062633.1|ensembl:ENSMUSG00000041248(gene)|ensembl:ENSMUST00000047334(transcript)|ensembl:ENSMUST00000213393(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010467"(gene expression)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030955"(potassium ion binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042277"(peptide binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0072359"(circulatory system development)|go:"GO:1900128"(regulation of G-protein activated inward rectifier potassium channel activity)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR003268(Potassium channel, inwardly rectifying, Kir1.1)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|reactome:R-MMU-1296067	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:ctGjxRRWBKD0M5ESJAJfkntznMo10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q3UQ44	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-16724715|ensembl:ENSMUSP00000067685	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:iqga2_mouse(display_long)|uniprotkb:Iqgap2(gene name)|psi-mi:Iqgap2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000021676(gene)|ensembl:ENSMUST00000068603(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005902"(microvillus)|go:"GO:0009986"(cell surface)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR036872|reactome:R-MMU-5626467|reactome:R-MMU-6798695|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013408|refseq:NP_081987.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:YD6GurtWVrIzYEBzXb7fdJ6qAWI10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q80ZF8	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-16724676|ensembl:ENSMUSP00000035612|ensembl:ENSMUSP00000116231|ensembl:ENSMUSP00000119804|uniprotkb:G3XA05	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:agrb3_mouse(display_long)|uniprotkb:Brain-specific angiogenesis inhibitor 3(gene name synonym)|uniprotkb:Adgrb3(gene name)|psi-mi:Adgrb3(display_short)|uniprotkb:Bai3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000033569(gene)|ensembl:ENSMUST00000041838(transcript)|ensembl:ENSMUST00000135518(transcript)|ensembl:ENSMUST00000151309(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0043083"(synaptic cleft)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061743"(motor learning)|go:"GO:0098794"(postsynapse)|go:"GO:0099558"(maintenance of synapse structure)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR008077(GPCR, family 2, brain-specific angiogenesis inhibitor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR032471|interpro:IPR036383|interpro:IPR036445|interpro:IPR043838|mint:Q80ZF8|refseq:NP_783573.4	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:gSLNnlXd3ua1ax9MiKbUQTHz/yQ10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8C8R3	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-774322|intact:EBI-2133064|uniprotkb:Q6PCN2|uniprotkb:Q3TM62|uniprotkb:Q3V2X0|uniprotkb:Q80ZZ7|uniprotkb:Q8BNC1|uniprotkb:Q8C445|uniprotkb:Q8CCV0|intact:EBI-2255612|intact:EBI-8314005|intact:MINT-4115219	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ank2_mouse(display_long)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:AnkB(gene name synonym)|uniprotkb:Ank2(gene name)|psi-mi:Ank2(display_short)|uniprotkb:Ankyrin-B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001029340.1|refseq:NP_848770.2|dip:DIP-58645N|mint:Q8C8R3|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001257"(regulation of cation channel activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:SkB13oxZVcKuMnI8r5ItFIq2pXQ10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P61982	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-359843|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q4FK44|uniprotkb:Q3UFD6|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSMUSP00000051223|ensembl:ENSMUSP00000143631	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:1433g_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_061359.2|ensembl:ENSMUSG00000051391(gene)|ensembl:ENSMUST00000055808(transcript)|ensembl:ENSMUST00000198270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61982|reactome:R-MMU-111447|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-9614399	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q6ZWR6	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-10760754|uniprotkb:Q8K3T7|uniprotkb:Q9ERT7|uniprotkb:Q9ERT8	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:syne1_mouse(display_long)|uniprotkb:Synaptic nuclear envelope protein 1(gene name synonym)|uniprotkb:Enaptin(gene name synonym)|uniprotkb:Myocyte nuclear envelope protein 1(gene name synonym)|uniprotkb:Nuclear envelope spectrin repeat protein 1(gene name synonym)|uniprotkb:Syne1(gene name)|psi-mi:Syne1(display_short)|uniprotkb:KASH domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	mint:Q6ZWR6|refseq:NP_001073154.1|go:"GO:0000932"(P-body)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0007030"(Golgi organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030496"(midbody)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051642"(centrosome localization)|go:"GO:0061886"(negative regulation of mini excitatory postsynaptic potential)|go:"GO:0090292"(nuclear matrix anchoring at nuclear membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903353"(regulation of nucleus organization)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR012315(Klarsicht/ANC-1/syne-1 homology)|interpro:IPR018159|interpro:IPR036872|dip:DIP-60966N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:96Ke3lpwOXQNnVBWVhwJaEpeNAM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P42208	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-772099|uniprotkb:Q3U9Y5|uniprotkb:B2RRZ2|ensembl:ENSMUSP00000027495|ensembl:ENSMUSP00000132850|ensembl:ENSMUSP00000136366	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:sept2_mouse(display_long)|uniprotkb:Sept2(gene name synonym)|uniprotkb:Septin2(gene name)|psi-mi:Septin2(display_short)|uniprotkb:Nedd5(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001153189.1|refseq:NP_001153190.1|refseq:NP_001153191.1|refseq:NP_035021.1|refseq:XP_006529304.1|refseq:XP_006529305.1|dip:DIP-32438N|ensembl:ENSMUSG00000026276(gene)|ensembl:ENSMUSG00000116048(gene)|ensembl:ENSMUST00000027495(transcript)|ensembl:ENSMUST00000168776(transcript)|ensembl:ENSMUST00000179353(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0000776"(kinetochore)|go:"GO:0002036"(regulation of L-glutamate import across plasma membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0005938"(cell cortex)|go:"GO:0005940"(septin ring)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051258"(protein polymerization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|interpro:IPR008113(Septin 2)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|rcsb pdb:3FTQ|reactome:R-MMU-5620912|mint:P42208	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:vk7UVRzpfbNxL4cxXJhd94mfQxc10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P34152	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-77070|uniprotkb:Q5DTH7|uniprotkb:Q8C513|uniprotkb:Q8CFH7|uniprotkb:Q8CHM2|uniprotkb:Q8K2S0|uniprotkb:Q9DAW3|intact:EBI-644981|uniprotkb:O08578|ensembl:ENSMUSP00000105663	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:fak1_mouse(display_long)|uniprotkb:Ptk2(gene name)|psi-mi:Ptk2(display_short)|uniprotkb:Fadk(gene name synonym)|uniprotkb:Fak(gene name synonym)|uniprotkb:Fak1(gene name synonym)|uniprotkb:Kiaa4203(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001123881.1|refseq:NP_032008.2|refseq:XP_006520496.1|dip:DIP-31045N|ensembl:ENSMUSG00000022607(gene)|ensembl:ENSMUST00000110036(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001764"(neuron migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007097"(nuclear migration)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:P34152|rcsb pdb:1K40|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:5F28|rcsb pdb:6BZ3|reactome:R-MMU-111465|reactome:R-MMU-2029482|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-375165|reactome:R-MMU-3928662|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-8874081|reactome:R-MMU-9009391	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:ZO/rmkDeJv5vec4ug3C3YrIwSIM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P63318	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-397096|uniprotkb:P05697|ensembl:ENSMUSP00000097874	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kpcg_mouse(display_long)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_035232.1|ensembl:ENSMUSG00000078816(gene)|ensembl:ENSMUST00000100301(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0005829"(cytosol)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|interpro:IPR020454|interpro:IPR035892|mint:P63318|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-416993|reactome:R-MMU-5099900|reactome:R-MMU-76005	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P16054	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-298451|ensembl:ENSMUSP00000094873|ensembl:ENSMUSP00000094874	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kpce_mouse(display_long)|uniprotkb:Prkce(gene name)|psi-mi:Prkce(display_short)|uniprotkb:Pkce(gene name synonym)|uniprotkb:Pkcea(gene name synonym)|uniprotkb:nPKC-epsilon(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000045038(gene)|ensembl:ENSMUST00000097274(transcript)|ensembl:ENSMUST00000097275(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027274|interpro:IPR034669|interpro:IPR035892|reactome:R-MMU-114508|reactome:R-MMU-1250196|reactome:R-MMU-1489509|reactome:R-MMU-2029485|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0005829"(cytosol)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035276"(ethanol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071944"(cell periphery)|go:"GO:0043278"(response to morphine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046872"(metal ion binding)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001031"(positive regulation of cellular glucuronidation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050996"(positive regulation of lipid catabolic process)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0051301"(cell division)|refseq:NP_035234.1|dip:DIP-31066N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:LBpr5ejW6fnkKwlXL6akJYv3H1M10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P31324	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-455340|uniprotkb:Q3UTZ1|uniprotkb:Q80ZM4|uniprotkb:Q8BRZ7|uniprotkb:B1B199|ensembl:ENSMUSP00000003079|ensembl:ENSMUSP00000039797	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kap3_mouse(display_long)|uniprotkb:Prkar2b(gene name)|psi-mi:Prkar2b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_035288.2|refseq:XP_006515077.1|dip:DIP-31571N|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P31324|rcsb pdb:3TNP|rcsb pdb:3TNQ|rcsb pdb:4WBB|rcsb pdb:4X6Q|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-432040|reactome:R-MMU-442720|reactome:R-MMU-5610787|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-983231|ensembl:ENSMUSG00000002997(gene)|ensembl:ENSMUST00000003079(transcript)|ensembl:ENSMUST00000036497(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007612"(learning)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0097332"(response to antipsychotic drug)|go:"GO:0097546"(ciliary base)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0097338"(response to clozapine)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:/d/0NSAnglWjmZAcQUn6ATpbJnE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q6R891	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-774681|uniprotkb:Q8K0X7|ensembl:ENSMUSP00000041732	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:neb2_mouse(display_long)|uniprotkb:Neurabin-II(gene name synonym)|uniprotkb:Spinophilin(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 9B(gene name synonym)|uniprotkb:Ppp1r9b(gene name)|psi-mi:Ppp1r9b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_758465.2|ensembl:ENSMUSG00000038976(gene)|ensembl:ENSMUST00000038696(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051015"(actin filament binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0061458"(reproductive system development)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097338"(response to clozapine)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903119"(protein localization to actin cytoskeleton)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904372"(positive regulation of protein localization to actin cortical patch)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904386"(response to L-phenylalanine derivative)|go:"GO:1990778"(protein localization to cell periphery)|go:"GO:1990780"(cytoplasmic side of dendritic spine plasma membrane)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR029921|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q6R891	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:UKGG1FQWWvX56wsI2kQB1jU5uOc10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q68FF6	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-645933|ensembl:ENSMUSP00000037210	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:G5E8K5	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-457262|uniprotkb:G5E8K4|uniprotkb:Q3TSJ8|uniprotkb:Q4U205|uniprotkb:Q4U206|uniprotkb:Q4U256|uniprotkb:Q4U260|uniprotkb:Q61307|uniprotkb:Q8CBN3|uniprotkb:Q8VC68|uniprotkb:O08866|uniprotkb:O08867|uniprotkb:Q61305|uniprotkb:Q61306|uniprotkb:Q61308|uniprotkb:Q61309|uniprotkb:Q61310|intact:EBI-2133089|ensembl:ENSMUSP00000090090|ensembl:ENSMUSP00000138326	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ank3_mouse(display_long)|uniprotkb:Ankyrin-G(gene name synonym)|uniprotkb:Ank3(gene name)|psi-mi:Ank3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_666117.2|refseq:XP_006513202.1|refseq:NP_033800.2|refseq:NP_733788.2|refseq:NP_733789.1|refseq:NP_733790.2|refseq:NP_733791.2|refseq:NP_733924.2|refseq:NP_733925.2|refseq:NP_733926.2|ensembl:ENSMUSG00000069601(gene)|ensembl:ENSMUST00000092434(transcript)|ensembl:ENSMUST00000182884(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010650"(positive regulation of cell communication by electrical coupling)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014704"(intercalated disc)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042383"(sarcolemma)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043194"(axon initial segment)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0050808"(synapse organization)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072660"(maintenance of protein location in plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0099612"(protein localization to axon)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1900827"(positive regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037971|interpro:IPR040745|mint:G5E8K5	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:sPFqnXYHQKlR6xjYE/VqOvNFxG010090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q3UHD9	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-771911|uniprotkb:Q5DU45|ensembl:ENSMUSP00000043466	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:agap2_mouse(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Kiaa0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001028435.1|refseq:NP_001287943.1|ensembl:ENSMUSG00000025422(gene)|ensembl:ENSMUST00000039259(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|go:"GO:0005768"(endosome)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:yq2lQtfk+FPqgT++CxAx2CS69nE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9DCD5	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-775733|uniprotkb:I7H459|uniprotkb:Q8CFL7|uniprotkb:Q8R5I2|ensembl:ENSMUSP00000153632	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:tjap1_mouse(display_long)|uniprotkb:Tight junction protein 4(gene name synonym)|uniprotkb:Protein incorporated later into tight junctions(gene name synonym)|uniprotkb:Tjap1(gene name)|psi-mi:Tjap1(display_short)|uniprotkb:Pilt(gene name synonym)|uniprotkb:Tjp4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_083027.1|refseq:NP_001239402.1|refseq:NP_001239403.1|refseq:NP_001239404.1|refseq:XP_011244979.1|refseq:XP_011244964.1|refseq:XP_011244965.1|refseq:XP_011244966.1|refseq:XP_011244967.1|refseq:XP_011244968.1|refseq:XP_011244969.1|refseq:XP_011244970.1|refseq:XP_011244971.1|refseq:XP_011244972.1|refseq:XP_011244973.1|refseq:XP_011244974.1|refseq:XP_011244975.1|refseq:XP_011244976.1|refseq:XP_011244977.1|refseq:XP_011244978.1|ensembl:ENSMUSG00000012296(gene)|ensembl:ENSMUST00000225413(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007030"(Golgi organization)|interpro:IPR028179|interpro:IPR043441|interpro:IPR043470	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:ZjCyubXIYjg4LeKZDQOjtxq3fac10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9WV34	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-444614|ensembl:ENSMUSP00000017458|uniprotkb:Q3T9W1|uniprotkb:Q3TT52|uniprotkb:Q3URK8|uniprotkb:B1AQF8	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:mpp2_mouse(display_long)|uniprotkb:Protein MPP2(gene name synonym)|uniprotkb:Discs large homolog 2(gene name synonym)|uniprotkb:Mpp2(gene name)|psi-mi:Mpp2(display_short)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_057904.1|ensembl:ENSMUSG00000017314(gene)|ensembl:ENSMUST00000017458(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035602|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q9WV34|go:"GO:0098919"(structural constituent of postsynaptic density)|refseq:XP_006533746.1|refseq:XP_006533747.1|refseq:XP_006533748.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:KythGhvpyj7gkND18iMe73LgdtM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q2WF71	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-877109|ensembl:ENSMUSP00000103923|uniprotkb:Q8C1V9|uniprotkb:Q99KT6|uniprotkb:Q460M4	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:lrfn1_mouse(display_long)|uniprotkb:Salm2(gene name synonym)|uniprotkb:Semo1(gene name synonym)|uniprotkb:Synaptic adhesion-like molecule 2(gene name synonym)|uniprotkb:Synaptic differentiation-enhancing molecule 1(gene name synonym)|uniprotkb:Lrfn1(gene name)|psi-mi:Lrfn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000030600(gene)|ensembl:ENSMUST00000108288(transcript)|go:"GO:0009986"(cell surface)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036116|interpro:IPR036179|rcsb pdb:5XWU|reactome:R-MMU-8849932|refseq:NP_001135393.1|refseq:NP_085039.2|refseq:XP_006540501.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:zhY1QqE+45IjjCGXAliKK0fxGOY10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P28741	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-6169413|ensembl:ENSMUSP00000112782|uniprotkb:Q7TSZ7	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kif3a_mouse(display_long)|uniprotkb:Kif3a(gene name)|psi-mi:Kif3a(display_short)|uniprotkb:Kif3(gene name synonym)|uniprotkb:Microtubule plus end-directed kinesin motor 3A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000018395(gene)|ensembl:ENSMUST00000120613(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001947"(heart looping)|go:"GO:0003341"(cilium movement)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008544"(epidermis development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016939"(kinesin II complex)|go:"GO:0019894"(kinesin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021915"(neural tube development)|go:"GO:0030507"(spectrin binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0036334"(epidermal stem cell homeostasis)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060271"(cilium assembly)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0120170"(intraciliary transport particle B binding)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905128"(positive regulation of axo-dendritic protein transport)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990939"|go:"GO:2000771"(positive regulation of establishment or maintenance of cell polarity regulating cell shape)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P28741|rcsb pdb:5JVR|rcsb pdb:5JX1|reactome:R-MMU-2132295|reactome:R-MMU-5610787|reactome:R-MMU-5620924|reactome:R-MMU-5635838|reactome:R-MMU-983189|reactome:R-MMU-6811434|refseq:NP_001277734.1|refseq:NP_001277735.1|refseq:NP_032469.2|dip:DIP-46318N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:3P8b4UgzwNTTXf1KVCB6+T+1+bk10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P28740	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-776122|uniprotkb:O54744|uniprotkb:Q91W03|ensembl:ENSMUSP00000022204	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kif2a_mouse(display_long)|uniprotkb:Kif2a(gene name)|psi-mi:Kif2a(display_short)|uniprotkb:Kif2(gene name synonym)|uniprotkb:Kns2(gene name synonym)|uniprotkb:Kinesin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001139251.1|refseq:XP_006517602.1|ensembl:ENSMUSG00000021693(gene)|ensembl:ENSMUST00000022204(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0051301"(cell division)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097228"(sperm principal piece)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P28740|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-6811434|reactome:R-MMU-68877|reactome:R-MMU-9648025|reactome:R-MMU-983189	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:xPWg0rzeKQooA3AM2Ics+e/QnRM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:E9Q4K7	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-9085496|ensembl:ENSMUSP00000098041	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:e9q4k7_mouse(display_long)|uniprotkb:Kif13b(gene name)|psi-mi:Kif13b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001074646.1|dip:DIP-61928N|ensembl:ENSMUSG00000060012(gene)|ensembl:ENSMUST00000100473(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005902"(microvillus)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0033270"(paranode region of axon)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:1990939"|interpro:IPR000253(Forkhead-associated)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019821|interpro:IPR022140|interpro:IPR022164|interpro:IPR027417|interpro:IPR032405|interpro:IPR036859|interpro:IPR036961|rcsb pdb:5B64	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:FPzCTsgR0iwDPBqRiio7hJ2k6/s10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P46660	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-400482|uniprotkb:Q61958|uniprotkb:Q8VCW5|ensembl:ENSMUSP00000041347	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ainx_mouse(display_long)|uniprotkb:Ina(gene name)|psi-mi:Ina(display_short)|uniprotkb:66 kDa neurofilament protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_666212.3|ensembl:ENSMUSG00000034336(gene)|ensembl:ENSMUST00000037636(transcript)|go:"GO:0005883"(neurofilament)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027703|interpro:IPR039008|mint:P46660	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:amjP0AajB8s2oXmV96wzyfz6evE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P35922	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-645094	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:O08553	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-446064|uniprotkb:Q6P5D0|ensembl:ENSMUSP00000022629	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dpyl2_mouse(display_long)|uniprotkb:Unc-33-like phosphoprotein 2(gene name synonym)|uniprotkb:Dpysl2(gene name)|psi-mi:Dpysl2(display_short)|uniprotkb:Crmp2(gene name synonym)|uniprotkb:Ulip2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_034085.2|ensembl:ENSMUSG00000022048(gene)|ensembl:ENSMUST00000022629(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043209"(myelin sheath)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098793"(presynapse)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030615|interpro:IPR032466|mint:O08553|rcsb pdb:5UQC|reactome:R-MMU-399956|reactome:R-MMU-437239	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:97yc8TNEPMcGtGNRLvl+KV+DYr010090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8K4R9	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-16724654|uniprotkb:Q6ZQL3|uniprotkb:Q80VS7|uniprotkb:Q8BUC8|uniprotkb:Q8BZ79	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dlgp5_mouse(display_long)|uniprotkb:Discs large homolog 7(gene name synonym)|uniprotkb:Disks large-associated protein DLG7(gene name synonym)|uniprotkb:Hepatoma up-regulated protein homolog(gene name synonym)|uniprotkb:Dlgap5(gene name)|psi-mi:Dlgap5(display_short)|uniprotkb:Dlg7(gene name synonym)|uniprotkb:Kiaa0008(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0023052"(signaling)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0034451"(centriolar satellite)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0051642"(centrosome localization)|refseq:NP_653136.2|interpro:IPR005026(Guanylate-kinase-associated protein)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:ZALyec8yXtYNUXNZqiSJE+AmaVM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:O88809	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-16724620|ensembl:ENSMUSP00000033642|ensembl:ENSMUSP00000084570|uniprotkb:Q6E5A4	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dcx_mouse(display_long)|uniprotkb:Doublin(gene name synonym)|uniprotkb:Lissencephalin-X(gene name synonym)|uniprotkb:Dcx(gene name)|psi-mi:Dcx(display_short)|uniprotkb:Dcn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000031285(gene)|ensembl:ENSMUST00000033642(transcript)|ensembl:ENSMUST00000087313(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0035082"(axoneme assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060041"(retina development in camera-type eye)|interpro:IPR003533(Doublecortin)|interpro:IPR017302(Neuronal migration protein doublecortin)|interpro:IPR036572|interpro:IPR040163|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|refseq:NP_001103692.1|refseq:NP_001103693.1|refseq:NP_001103694.1|refseq:NP_034155.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:bZVdhkO518ZmQJpBRfIqaTPon1Y10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9QXS6	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-445208|uniprotkb:A2CG16|uniprotkb:Q3V234|uniprotkb:Q922X1|uniprotkb:Q9QXS5|ensembl:ENSMUSP00000021950	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dreb_mouse(display_long)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:Dbn1(gene name)|psi-mi:Dbn1(display_short)|uniprotkb:Drba(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001170842.1|refseq:NP_001170843.1|refseq:NP_062787.2|ensembl:ENSMUSG00000034675(gene)|ensembl:ENSMUST00000021950(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0005856"(cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048699"(generation of neurons)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0098828"(modulation of inhibitory postsynaptic potential)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:1904113"(negative regulation of muscle filament sliding)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q9QXS6|reactome:R-MMU-9013405|reactome:R-MMU-9013407|reactome:R-MMU-9013418|reactome:R-MMU-9013422	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:ArZUGZNIUfSwoIketPcPCXlSM8410090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q02248	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8BMA3	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-16724595|ensembl:ENSMUSP00000015346|uniprotkb:Q3UDS2|uniprotkb:Q8K2K0	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:cnkr3_mouse(display_long)|uniprotkb:CNK homolog protein 3(gene name synonym)|uniprotkb:CNKSR family member 3(gene name synonym)|uniprotkb:Maguin-like protein(gene name synonym)|uniprotkb:Cnksr3(gene name)|psi-mi:Cnksr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000015202(gene)|ensembl:ENSMUST00000015346(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|refseq:NP_766134.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:VU017cJ6L0oSQSKNSH5wShA80Lg10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:D3YYY8	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-16724572|ensembl:ENSMUSP00000078281	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:d3yyy8_mouse(display_long)|uniprotkb:Arhgef26(gene name)|psi-mi:Arhgef26(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000036885(gene)|ensembl:ENSMUST00000079300(transcript)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035797|interpro:IPR035899|interpro:IPR036028|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-9013148|reactome:R-MMU-9013408|refseq:NP_001074764.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:oPA8vFhn55DQ/z62v+jX2U1jkyM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q3UL36	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-6910384|ensembl:ENSMUSP00000039493|uniprotkb:Q80XJ0	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:argl1_mouse(display_long)|uniprotkb:Arglu1(gene name)|psi-mi:Arglu1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000040459(gene)|ensembl:ENSMUST00000048545(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|interpro:IPR033371|refseq:NP_789819.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:43h52BC+BsS6BK7VRNDkfVsJNa410090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P62259	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9CQV8	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-771608|uniprotkb:O70455|uniprotkb:Q3TY33|uniprotkb:Q3UAN6|ensembl:ENSMUSP00000018470	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:1433b_mouse(display_long)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Ywhab(gene name)|psi-mi:Ywhab(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_061223.2|refseq:XP_006499972.1|reactome:R-MMU-111447|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-170968|reactome:R-MMU-2028269|reactome:R-MMU-392517|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-75035|reactome:R-MMU-9614399|ensembl:ENSMUSG00000018326(gene)|ensembl:ENSMUST00000018470(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:4GNT|rcsb pdb:5F74|rcsb pdb:5WFU|rcsb pdb:5WFX	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:g94luGOxfq+Jbi0ztZ7gbAkp+2A10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9D2M8	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-911251|uniprotkb:Q8BGH6|uniprotkb:Q8CE99|uniprotkb:Q8K2V7|uniprotkb:Q9CYD7|uniprotkb:Q9ERI8|uniprotkb:A6X924|ensembl:ENSMUSP00000111443	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ub2v2_mouse(display_long)|uniprotkb:Ubc-like protein MMS2(gene name synonym)|uniprotkb:Ube2v2(gene name)|psi-mi:Ube2v2(display_short)|uniprotkb:Mms2(gene name synonym)|uniprotkb:Uev2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001152823.1|refseq:NP_076074.2|ensembl:ENSMUSG00000022674(gene)|ensembl:ENSMUST00000115777(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042275"(error-free postreplication DNA repair)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|mint:Q9D2M8|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-5696395|reactome:R-MMU-69473|reactome:R-MMU-8866654|reactome:R-MMU-983168	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:nY0ENcwjbooLvqOoe1NdM4Dp4J410090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9CZY3	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2310567|uniprotkb:Q8VEB5|uniprotkb:Q9ERI7|uniprotkb:A2A467|ensembl:ENSMUSP00000104830	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ub2v1_mouse(display_long)|uniprotkb:Ube2v1(gene name)|psi-mi:Ube2v1(display_short)|uniprotkb:Croc1(gene name synonym)|uniprotkb:CROC-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_075719.1|refseq:NP_001298075.1|ensembl:ENSMUSG00000078923(gene)|ensembl:ENSMUST00000109207(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0042275"(error-free postreplication DNA repair)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|reactome:R-MMU-168638|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-9646399|reactome:R-MMU-975144|reactome:R-MMU-983168	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:IQx/TVZCHoF9Jl512EHg5vG4gBg10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q02053	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2310520|uniprotkb:A6H6S6|uniprotkb:P31253|uniprotkb:Q542H8|ensembl:ENSMUSP00000001989|ensembl:ENSMUSP00000086626	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:uba1_mouse(display_long)|uniprotkb:Uba1(gene name)|psi-mi:Uba1(display_short)|uniprotkb:Sbx(gene name synonym)|uniprotkb:Ube1(gene name synonym)|uniprotkb:Ube1ax(gene name synonym)|uniprotkb:Ube1x(gene name synonym)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Ubiquitin-like modifier-activating enzyme 1 X(gene name synonym)|uniprotkb:Ubiquitin-activating enzyme E1 X(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001129557.1|refseq:NP_001263245.1|refseq:NP_001263246.1|refseq:NP_033483.2|ensembl:ENSMUSG00000001924(gene)|ensembl:ENSMUST00000001989(transcript)|ensembl:ENSMUST00000089217(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030057"(desmosome)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0032446"(protein modification by small protein conjugation)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:Q02053|rcsb pdb:1Z7L|rcsb pdb:2LZJ|rcsb pdb:2V31|reactome:R-MMU-8866652|reactome:R-MMU-983168|interpro:IPR019572	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:358Lm1CC2dWXeDL+IXAM2KaOlqM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q922F4	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2310445|ensembl:ENSMUSP00000001513	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:tbb6_mouse(display_long)|uniprotkb:Tubb6(gene name)|psi-mi:Tubb6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_080749.2|ensembl:ENSMUSG00000001473(gene)|ensembl:ENSMUST00000001513(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q922F4|reactome:R-MMU-190840|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3371497|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:HJaJs+zsyUZjmGSYEmEbcln56Z410090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9CWF2	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2794256|uniprotkb:Q3TG26|ensembl:ENSMUSP00000075178	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:tbb2b_mouse(display_long)|uniprotkb:Tubb2b(gene name)|psi-mi:Tubb2b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_076205.1|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1990403"(embryonic brain development)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9CWF2|reactome:R-MMU-190840|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3371497|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8955332|ensembl:ENSMUSG00000045136(gene)|ensembl:ENSMUST00000075774(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0046982"(protein heterodimerization activity)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:sluQMryNuOvp6xlV558+agiRwvE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q60803	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-520135|uniprotkb:B2RPW3|uniprotkb:Q62380|ensembl:ENSMUSP00000021706	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:traf3_mouse(display_long)|uniprotkb:CD40 receptor-associated factor 1(gene name synonym)|uniprotkb:TRAFAMN(gene name synonym)|uniprotkb:Traf3(gene name)|psi-mi:Traf3(display_short)|uniprotkb:Craf1(gene name synonym)|uniprotkb:Trafamn(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_035762.2|ensembl:ENSMUSG00000021277(gene)|ensembl:ENSMUST00000021706(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027128|interpro:IPR037304|interpro:IPR043211|mint:Q60803|rcsb pdb:4GHU|reactome:R-MMU-5668541|reactome:R-MMU-5676594|reactome:R-MMU-5689896|reactome:R-MMU-936964|refseq:XP_006515861.1|refseq:XP_006515862.1|refseq:XP_006515863.1|refseq:XP_006515864.1|dip:DIP-34050N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:2MrUSSGdyGB3zrZ39xovGDK6ysE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P46096	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-445340|ensembl:ENSMUSP00000063293|ensembl:ENSMUSP00000100912	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:syt1_mouse(display_long)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym)|uniprotkb:Syt1(gene name)|psi-mi:Syt1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001239271.1|refseq:NP_033332.1|refseq:XP_006513509.1|refseq:XP_006513510.1|refseq:XP_006513511.1|refseq:NP_001239270.1|ensembl:ENSMUSG00000035864(gene)|ensembl:ENSMUST00000064054(transcript)|ensembl:ENSMUST00000105276(transcript)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051291"(protein heterooligomerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0000149"(SNARE binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|refseq:XP_017169355.1|go:"GO:0060076"(excitatory synapse)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071911"(synchronous neurotransmitter secretion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098746"(fast, calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903235"(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903305"(regulation of regulated secretory pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|mint:P46096|rcsb pdb:5T0R|rcsb pdb:5T0S|rcsb pdb:5VFE|rcsb pdb:5VFF|rcsb pdb:5VFG|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-888590|dip:DIP-31322N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:CxQGrKu3l0pEzQ3aJZBJ/GZMyEA10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8CHC4	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-775693	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:synj1_mouse(display_long)|uniprotkb:Synj1(gene name)|psi-mi:Synj1(display_short)|uniprotkb:Kiaa0910(gene name synonym)|uniprotkb:Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	interpro:IPR015047(Region of unknown function DUF1866)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002013(Synaptojanin, N-terminal)|interpro:IPR034971|interpro:IPR034972|interpro:IPR035979|interpro:IPR036691|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:Q8CHC4|go:"GO:0003723"(RNA binding)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014015"(positive regulation of gliogenesis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030118"(clathrin coat)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904980"(positive regulation of endosome organization)|go:"GO:1990175"(EH domain binding)|reactome:R-MMU-1660499|reactome:R-MMU-1855183|reactome:R-MMU-1855204|reactome:R-MMU-8856828	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:jBMEFlptiz90uS1F1ajBc7zR3vo10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:F6SEU4	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-5797569|ensembl:ENSMUSP00000141686	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q62261	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P43006	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-444587|ensembl:ENSMUSP00000079100|uniprotkb:O35877|uniprotkb:O54686|uniprotkb:O54687	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:eaa2_mouse(display_long)|uniprotkb:Sodium-dependent glutamate/aspartate transporter 2(gene name synonym)|uniprotkb:GLT-1(gene name synonym)|uniprotkb:Solute carrier family 1 member 2(gene name synonym)|uniprotkb:Slc1a2(gene name)|psi-mi:Slc1a2(display_short)|uniprotkb:Eaat2(gene name synonym)|uniprotkb:Glt1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001070982.1|refseq:NP_001070983.1|refseq:NP_035523.1|go:"GO:0033229"(cysteine transmembrane transporter activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|ensembl:ENSMUSG00000005089(gene)|ensembl:ENSMUST00000080210(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005314"(high-affinity glutamate transmembrane transporter activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007632"(visual behavior)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0015501"("glutamate:sodium symporter activity")|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030424"(axon)|go:"GO:0030534"(adult behavior)|go:"GO:0030673"(axolemma)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043200"(response to amino acid)|go:"GO:0044297"(cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098796"(membrane protein complex)|go:"GO:0098810"(neurotransmitter reuptake)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR001991("Sodium:dicarboxylate symporter")|interpro:IPR018107|interpro:IPR036458|mint:P43006|reactome:R-MMU-210455|reactome:R-MMU-210500|reactome:R-MMU-425393	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:Up4px1d7xDeKcqcMDHsMCDbbF7810090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q4ACU6	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q80Z38	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-770338|uniprotkb:E9QPH7|uniprotkb:Q3UTK4|uniprotkb:Q5DU07	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:shan2_mouse(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)|uniprotkb:Kiaa1022(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001074839.2|refseq:NP_001106844.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001452(Src homology-3)|refseq:XP_006508596.1|reactome:R-MMU-6794361|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0043005"(neuron projection)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:OTohbAMxKtx7/WWwWXDc+c24HvQ10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:D3YZU1	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2314988|ensembl:ENSMUSP00000103571	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:shan1_mouse(display_long)|uniprotkb:Shank1(gene name)|psi-mi:Shank1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001029287.1|refseq:XP_006540927.1|ensembl:ENSMUSG00000038738(gene)|ensembl:ENSMUST00000107938(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:TbxBmjjabypLqTlAx9zbkSAAzpk10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q91V61	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-775926|uniprotkb:Q544M7|uniprotkb:Q8C1Z2|ensembl:ENSMUSP00000059419	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:sfxn3_mouse(display_long)|uniprotkb:Sfxn3(gene name)|psi-mi:Sfxn3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001171483.1|refseq:NP_444427.1|refseq:XP_006527556.1|ensembl:ENSMUSG00000025212(gene)|ensembl:ENSMUST00000062213(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0022889"(serine transmembrane transporter activity)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0140300"(serine import into mitochondrion)|go:"GO:1990542"(mitochondrial transmembrane transport)|interpro:IPR004686(Tricarboxylate/iron carrier)|mint:Q91V61	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:2SWKs65uF9TnCot4JyNDHb6Bf1I10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9Z2Q6	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-772125|uniprotkb:Q3UYG4|uniprotkb:Q6PB74|uniprotkb:B2RUC5|ensembl:ENSMUSP00000094750	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:sept5_mouse(display_long)|uniprotkb:Septin5(gene name)|psi-mi:Septin5(display_short)|uniprotkb:Cell division control-related protein 1(gene name synonym)|uniprotkb:Peanut-like protein 1(gene name synonym)|uniprotkb:Pnutl1(gene name synonym)|uniprotkb:Sept5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_998779.2|ensembl:ENSMUSG00000072214(gene)|ensembl:ENSMUST00000096987(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0005940"(septin ring)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030534"(adult behavior)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035176"(social behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0045202"(synapse)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098793"(presynapse)|go:"GO:0099148"(regulation of synaptic vesicle docking)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030647|mint:Q9Z2Q6	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:9ZY1BrCZ/7+83bn/q3OQkZoi8pg10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8C1B7	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-772076|uniprotkb:Q3TBA0|uniprotkb:Q3TC24|uniprotkb:Q5D0F0|uniprotkb:Q6P2K5|uniprotkb:Q6P6I0|ensembl:ENSMUSP00000143928	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:sep11_mouse(display_long)|uniprotkb:Septin11(gene name)|psi-mi:Septin11(display_short)|uniprotkb:D5Ertd606e(gene name synonym)|uniprotkb:Sept11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001009818.1|refseq:NP_001297598.1|refseq:NP_001297600.1|ensembl:ENSMUSG00000058013(gene)|ensembl:ENSMUST00000201421(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005940"(septin ring)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099629"(postsynaptic specialization of symmetric synapse)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|mint:Q8C1B7	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:RfdukqyhC/1qeJHPQmrz7ryDmdY10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P70336	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-771800|uniprotkb:Q8BR64|uniprotkb:Q8CBR0|uniprotkb:A5XDA7	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:rock2_mouse(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 2(gene name synonym)|uniprotkb:p164 ROCK-2(gene name synonym)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase II(gene name synonym)|uniprotkb:Rock2(gene name)|psi-mi:Rock2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_033098.2|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR015008(Rho Binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011072(HR1 rho-binding repeat)|mint:P70336|interpro:IPR037311|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0150033"(negative regulation of protein localization to lysosome)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5627117|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013407|reactome:R-MMU-9013422	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:XGh4GUDWts/RI6osd4zKXeh0lAE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9Z268	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2013210|uniprotkb:Q99K69|ensembl:ENSMUSP00000031606|ensembl:ENSMUSP00000123266	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:rasl1_mouse(display_long)|uniprotkb:Rasal1(gene name)|psi-mi:Rasal1(display_short)|uniprotkb:Rasal(gene name synonym)|uniprotkb:RAS protein activator like 1(gene name synonym)|uniprotkb:Ras GTPase-activating-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:XP_006530272.1|refseq:XP_006530273.1|refseq:NP_038860.2|ensembl:ENSMUSG00000029602(gene)|ensembl:ENSMUST00000031606(transcript)|ensembl:ENSMUST00000156722(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028555|interpro:IPR035892|interpro:IPR037776|interpro:IPR039360|mint:Q9Z268|reactome:R-MMU-5658442	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:VbTtsNfJC0uXiZYAtnOIFBPfLkA10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P61226	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-16724536|ensembl:ENSMUSP00000038841|uniprotkb:P17964|uniprotkb:Q96EG5|uniprotkb:Q9CXG0	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:rap2b_mouse(display_long)|uniprotkb:Rap2b(gene name)|psi-mi:Rap2b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000036894(gene)|ensembl:ENSMUST00000049064(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041840|reactome:R-MMU-6798695|refseq:NP_082988.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:dFHHIYuDf3lTGSX0Nys6IE9ONvs10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P63001	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P62823	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-4286215|uniprotkb:Q62858|uniprotkb:Q62974|uniprotkb:Q63482|uniprotkb:Q9CXQ1|ensembl:ENSMUSP00000132945	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:rab3c_mouse(display_long)|uniprotkb:Rab3c(gene name)|psi-mi:Rab3c(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_076341.1|ensembl:ENSMUSG00000021700(gene)|ensembl:ENSMUST00000167824(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037872|reactome:R-MMU-8873719	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:F0BXS2E7Unlk+uNhGFX8SXRN9hA10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9CZT8	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-911649|uniprotkb:Q80WV9|ensembl:ENSMUSP00000003502|ensembl:ENSMUSP00000102261|uniprotkb:Q920F1	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:rab3b_mouse(display_long)|uniprotkb:Rab3b(gene name)|psi-mi:Rab3b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000003411(gene)|ensembl:ENSMUST00000003502(transcript)|ensembl:ENSMUST00000106650(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037872|mint:Q9CZT8|reactome:R-MMU-8873719|refseq:NP_076026.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:4WkkwI5ty+Y60GheT3a0s2RVr2Q10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q91V41	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-3869482|ensembl:ENSMUSP00000028238	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:rab14_mouse(display_long)|uniprotkb:Rab14(gene name)|psi-mi:Rab14(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_080973.1|ensembl:ENSMUST00000028238(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005795"(Golgi stack)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045176"(apical protein localization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090387"(phagolysosome assembly involved in apoptotic cell clearance)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030702|mint:Q91V41|reactome:R-MMU-1660499|reactome:R-MMU-6798695|reactome:R-MMU-8873719|reactome:R-MMU-8876198|ensembl:ENSMUSG00000026878(gene)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:qFP8UXDCPt/RcLTWlZLaitH2LF410090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P61027	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-911581|uniprotkb:O88386|uniprotkb:Q9D7X6|ensembl:ENSMUSP00000021001	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:rab10_mouse(display_long)|uniprotkb:Rab10(gene name)|psi-mi:Rab10(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_057885.1|dip:DIP-37720N|ensembl:ENSMUSG00000020671(gene)|ensembl:ENSMUST00000021001(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0031489"(myosin V binding)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051021"(GDP-dissociation inhibitor binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61027|reactome:R-MMU-6798695|reactome:R-MMU-8873719|reactome:R-MMU-8876198	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:ZbfLtWtXl3z6/MYyhiZp6P1Y5tE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:O35449	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-774560|ensembl:ENSMUSP00000015620	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:prrt1_mouse(display_long)|uniprotkb:Synapse differentiation-induced protein 4(gene name synonym)|uniprotkb:Prrt1(gene name)|psi-mi:Prrt1(display_short)|uniprotkb:Ng5(gene name synonym)|uniprotkb:Dispanin subfamily D member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_112152.1|ensembl:ENSMUSG00000015476(gene)|ensembl:ENSMUST00000015620(transcript)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007611"(learning or memory)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0030545"(signaling receptor regulator activity)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0050808"(synapse organization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2000311"(regulation of AMPA receptor activity)|interpro:IPR007593(Interferon-induced transmembrane protein)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:K6vAxG6MRWmncPgTJOsyLkDriXE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P68404	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P68181	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-400685|uniprotkb:P05206|uniprotkb:Q3TQH5|uniprotkb:Q3UDD0|uniprotkb:Q3UTH5|ensembl:ENSMUSP00000099573	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kapcb_mouse(display_long)|uniprotkb:Prkacb(gene name)|psi-mi:Prkacb(display_short)|uniprotkb:Pkacb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001157670.1|refseq:NP_001157671.1|refseq:NP_001157672.1|refseq:NP_035230.1|ensembl:ENSMUSG00000005034(gene)|ensembl:ENSMUST00000102515(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0097338"(response to clozapine)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044109|mint:P68181|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356|reactome:R-MMU-432040|reactome:R-MMU-4420097|reactome:R-MMU-442720|reactome:R-MMU-5610785|reactome:R-MMU-5610787|reactome:R-MMU-5621575|reactome:R-MMU-5687128|reactome:R-MMU-8853659|reactome:R-MMU-8963896|reactome:R-MMU-983231	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:9278c8xZsjU90+vryXpzUc0y/G010090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q61171	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-444957|uniprotkb:O88376|uniprotkb:Q60796|uniprotkb:Q9CWJ4|uniprotkb:Q9DB49|ensembl:ENSMUSP00000005292|ensembl:ENSMUSP00000105355|ensembl:ENSMUSP00000105356|ensembl:ENSMUSP00000126451	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:prdx2_mouse(display_long)|uniprotkb:Thioredoxin-dependent peroxiredoxin 2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 1(gene name synonym)|uniprotkb:Thiol-specific antioxidant protein(gene name synonym)|uniprotkb:Prdx2(gene name)|psi-mi:Prdx2(display_short)|uniprotkb:Tdpx1(gene name synonym)|uniprotkb:Tpx(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_035693.3|go:"GO:0042098"(T cell proliferation)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q61171|reactome:R-MMU-3299685|reactome:R-MMU-5628897|go:"GO:0034599"(cellular response to oxidative stress)|refseq:NP_001304314.1|ensembl:ENSMUSG00000005161(gene)|ensembl:ENSMUST00000005292(transcript)|ensembl:ENSMUST00000109733(transcript)|ensembl:ENSMUST00000109734(transcript)|ensembl:ENSMUST00000164807(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002536"(respiratory burst involved in inflammatory response)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008430"(selenium binding)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:P1NxwIOnv1n4sNzQWtFjy2znSbA10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P35700	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-444948|uniprotkb:Q3UBV4|uniprotkb:Q9CWI2|ensembl:ENSMUSP00000102078|ensembl:ENSMUSP00000114159	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:prdx1_mouse(display_long)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Osteoblast-specific factor 3(gene name synonym)|uniprotkb:Macrophage 23 kDa stress protein(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Prdx1(gene name)|psi-mi:Prdx1(display_short)|uniprotkb:Msp23(gene name synonym)|uniprotkb:Paga(gene name synonym)|uniprotkb:Tdpx2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_035164.1|ensembl:ENSMUST00000135573(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000791"(euchromatin)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:P35700|reactome:R-MMU-3299685|reactome:R-MMU-5628897|ensembl:ENSMUST00000106470(transcript)|ensembl:ENSMUSG00000028691(gene)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:xOppWev1GtpILoJ1rY+tSPoymVU10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P48453	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-642618|uniprotkb:Q6NZR4|ensembl:ENSMUSP00000125722	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:pp2bb_mouse(display_long)|uniprotkb:Calmodulin-dependent calcineurin A subunit beta isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Ppp3cb(gene name)|psi-mi:Ppp3cb(display_short)|uniprotkb:Calnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032940.1|refseq:NP_001297355.1|refseq:NP_001297356.1|ensembl:ENSMUSG00000021816(gene)|ensembl:ENSMUST00000159027(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P48453|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|go:"GO:0005516"(calmodulin binding)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:YD7q3dcL87htgwHRd5m5ReMlqd010090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P63328	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-397208|uniprotkb:P12816|uniprotkb:P20652|uniprotkb:Q3UCU1|uniprotkb:Q64135|ensembl:ENSMUSP00000053101	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:pp2ba_mouse(display_long)|uniprotkb:Ppp3ca(gene name)|psi-mi:Ppp3ca(display_short)|uniprotkb:Calna(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032939.1|refseq:NP_001280551.1|ensembl:ENSMUSG00000028161(gene)|ensembl:ENSMUST00000056758(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042383"(sarcolemma)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P63328|rcsb pdb:4ORB|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|dip:DIP-31543N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:98yAyDGZZxKYOv22ejceyfJbvao10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P62141	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-352338|uniprotkb:P37140|uniprotkb:Q3TBE5|uniprotkb:Q3TL90|uniprotkb:Q542E7|uniprotkb:Q8C285|uniprotkb:Q9DBY2|ensembl:ENSMUSP00000015100|ensembl:ENSMUSP00000144047	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:pp1b_mouse(display_long)|uniprotkb:Ppp1cb(gene name)|psi-mi:Ppp1cb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_766295.2|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|mint:P62141|reactome:R-MMU-2565942|reactome:R-MMU-5625740|reactome:R-MMU-5627123|reactome:R-MMU-5673000|ensembl:ENSMUSG00000014956(gene)|ensembl:ENSMUST00000015100(transcript)|ensembl:ENSMUST00000201360(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:VtNJVyimeiEuRDDWtGswTqoSOH810090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P62137	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-357187|ensembl:ENSMUSP00000039109|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:Q3U7G7|uniprotkb:Q9Z1G2	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:pp1a_mouse(display_long)|uniprotkb:Ppp1ca(gene name)|psi-mi:Ppp1ca(display_short)|uniprotkb:Ppp1a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62137|rcsb pdb:5ZQV|rcsb pdb:5ZT0|reactome:R-MMU-180024|ensembl:ENSMUSG00000040385(gene)|ensembl:ENSMUST00000046094(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|refseq:NP_114074.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:kr38FkfqhN5ex5rxh4ZJbSdd8IM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P24369	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-494280|ensembl:ENSMUSP00000034947	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ppib_mouse(display_long)|uniprotkb:Cyclophilin B(gene name synonym)|uniprotkb:S-cyclophilin(gene name synonym)|uniprotkb:CYP-S1(gene name synonym)|uniprotkb:Ppib(gene name)|psi-mi:Ppib(display_short)|uniprotkb:Rotamase B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_035279.2|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0005737"(cytoplasm)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0060348"(bone development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:P24369|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0006457"(protein folding)|reactome:R-MMU-1650814|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|ensembl:ENSMUSG00000032383(gene)|ensembl:ENSMUST00000034947(transcript)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:Jp4wVPlfj3WNwhuh/Cvuk1TR7sY10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P17742	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-1206043|uniprotkb:Q9CWJ5|uniprotkb:Q9R137|ensembl:ENSMUSP00000117987	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ppia_mouse(display_long)|uniprotkb:Ppia(gene name)|psi-mi:Ppia(display_short)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:SP18(gene name synonym)|uniprotkb:Rotamase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032933.1|reactome:R-MMU-210991|reactome:R-MMU-6798695|rcsb pdb:6FK1|ensembl:ENSMUSG00000071866(gene)|ensembl:ENSMUST00000132846(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:P17742	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:VwIoW2yfdaAEwZj6MfekFYqkZjw10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q99JY8	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-773683|uniprotkb:Q3TVM4|uniprotkb:Q3TXR7|uniprotkb:Q8BTB7|ensembl:ENSMUSP00000065719	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:plpp3_mouse(display_long)|uniprotkb:Plpp3(gene name)|psi-mi:Plpp3(display_short)|uniprotkb:Lipid phosphate phosphohydrolase 3(gene name synonym)|uniprotkb:Lpp3(gene name synonym)|uniprotkb:PAP2-beta(gene name synonym)|uniprotkb:Phosphatidate phosphohydrolase type 2b(gene name synonym)|uniprotkb:Phosphatidic acid phosphatase 2b(gene name synonym)|uniprotkb:Ppap2b(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_542122.1|ensembl:ENSMUSG00000028517(gene)|ensembl:ENSMUST00000064139(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001568"(blood vessel development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008195"(phosphatidate phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042392"(sphingosine-1-phosphate phosphatase activity)|go:"GO:0042577"(lipid phosphatase activity)|go:"GO:0044328"(canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration)|go:"GO:0044329"(canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion)|go:"GO:0044330"(canonical Wnt signaling pathway involved in positive regulation of wound healing)|go:"GO:0045121"(membrane raft)|go:"GO:0046839"(phospholipid dephosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0106235"(ceramide-1-phosphate phosphatase activity)|go:"GO:1902068"(regulation of sphingolipid mediated signaling pathway)|interpro:IPR000326(Phosphatidic acid phosphatase type 2/haloperoxidase)|interpro:IPR028675|interpro:IPR036938|interpro:IPR043216|mint:Q99JY8|reactome:R-MMU-1660661	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:k0j2BFjYFftNCFSr6/PrQfurHck10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P60202	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2310045|uniprotkb:P04400|uniprotkb:P06905|uniprotkb:Q9WUS9|ensembl:ENSMUSP00000033800	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:mypr_mouse(display_long)|uniprotkb:Plp1(gene name)|psi-mi:Plp1(display_short)|uniprotkb:Plp(gene name synonym)|uniprotkb:Lipophilin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001277490.1|refseq:NP_035253.1|dip:DIP-46200N|refseq:XP_017173919.1|refseq:XP_017173920.1|refseq:XP_017173921.1|refseq:NP_001277491.1|ensembl:ENSMUSG00000031425(gene)|ensembl:ENSMUST00000033800(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008366"(axon ensheathment)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0042552"(myelination)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0061564"(axon development)|go:"GO:0098990"(AMPA selective glutamate receptor signaling pathway)|go:"GO:1904427"(positive regulation of calcium ion transmembrane transport)|interpro:IPR001614(Myelin proteolipid protein PLP)|interpro:IPR018237|mint:P60202	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:b7pt7FJVt10Iu1tTMeiVYEu5r/k10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:O35129	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-445002|uniprotkb:O89075|uniprotkb:Q61336|ensembl:ENSMUSP00000004375	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:phb2_mouse(display_long)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Repressor of estrogen receptor activity(gene name synonym)|uniprotkb:Phb2(gene name)|psi-mi:Phb2(display_short)|uniprotkb:Bap(gene name synonym)|uniprotkb:Bcap37(gene name synonym)|uniprotkb:Rea(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_031557.2|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098800"(inner mitochondrial membrane protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:O35129|reactome:R-MMU-8949664|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|ensembl:ENSMUSG00000004264(gene)|ensembl:ENSMUST00000004375(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016363"(nuclear matrix)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0016477"(cell migration)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:h4pib54mBeQgOKCe/hib58LM26w10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8BX10	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-776241|uniprotkb:Q3UK19|uniprotkb:Q80VY8|uniprotkb:Q8BM78|uniprotkb:Q9CZU2|uniprotkb:B2RSM6|ensembl:ENSMUSP00000108124	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:pgam5_mouse(display_long)|uniprotkb:Pgam5(gene name)|psi-mi:Pgam5(display_short)|uniprotkb:Phosphoglycerate mutase family member 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001157010.1|refseq:NP_082549.2|dip:DIP-32064N|ensembl:ENSMUSG00000029500(gene)|ensembl:ENSMUST00000112505(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|mint:Q8BX10|reactome:R-MMU-8934903	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:m8AARXCf3lNoMo3JN7zcJNw5gwY10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q922S4	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-772547|uniprotkb:Q8K2U1|uniprotkb:Q3TCR8|uniprotkb:Q3TXZ6|ensembl:ENSMUSP00000131553	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:pde2a_mouse(display_long)|uniprotkb:Cyclic GMP-stimulated phosphodiesterase(gene name synonym)|uniprotkb:Pde2a(gene name)|psi-mi:Pde2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001137321.1|refseq:XP_006507590.1|refseq:NP_001137320.1|ensembl:ENSMUSG00000110195(gene)|ensembl:ENSMUST00000163751(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004118"(cGMP-stimulated cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010749"(regulation of nitric oxide mediated signal transduction)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0035904"(aorta development)|go:"GO:0036004"(GAF domain binding)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:1904613"(cellular response to 2,3,7,8-tetrachlorodibenzodioxine)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|mint:Q922S4|rcsb pdb:1MC0|reactome:R-MMU-418457|reactome:R-MMU-418555	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:Mb4AbU3k9lQ/qLUITe5AJ1NZdk810090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q99LX0	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-1634273|uniprotkb:O88306|uniprotkb:Q3THB9|uniprotkb:Q3U509|ensembl:ENSMUSP00000030805|ensembl:ENSMUSP00000101298|ensembl:ENSMUSP00000101299|ensembl:ENSMUSP00000101300	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:park7_mouse(display_long)|uniprotkb:Park7(gene name)|psi-mi:Park7(display_short)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_065594.2|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|mint:Q99LX0|reactome:R-MMU-3899300|reactome:R-MMU-9646399|ensembl:ENSMUSG00000028964(gene)|ensembl:ENSMUST00000030805(transcript)|ensembl:ENSMUST00000105673(transcript)|ensembl:ENSMUST00000105674(transcript)|ensembl:ENSMUST00000105675(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007338"(single fertilization)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0061827"(sperm head)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:dfkL4WeM+WgrYJa3aYTWbFyi0bk10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P46460	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-398006|uniprotkb:A2A646|uniprotkb:Q8BQ65|uniprotkb:Q8C3R2|uniprotkb:Q8CCT9|uniprotkb:Q8CEF0|uniprotkb:Q923C6|ensembl:ENSMUSP00000099364	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:nsf_mouse(display_long)|uniprotkb:Nsf(gene name)|psi-mi:Nsf(display_short)|uniprotkb:Skd2(gene name synonym)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 2"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032766.2|ensembl:ENSMUSG00000034187(gene)|ensembl:ENSMUST00000103075(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46460|reactome:R-MMU-204005|reactome:R-MMU-416993|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811438|reactome:R-MMU-6811440	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:mqNfvBVWEdD4caFZug82c88vwE410090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8BYM5	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-775074|uniprotkb:A2AGI1|uniprotkb:Q8BXR4|ensembl:ENSMUSP00000066304	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:nlgn3_mouse(display_long)|uniprotkb:Gliotactin homolog(gene name synonym)|uniprotkb:Nlgn3(gene name)|psi-mi:Nlgn3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_766520.2|ensembl:ENSMUSG00000031302(gene)|ensembl:ENSMUST00000065858(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030024|mint:Q8BYM5|rcsb pdb:7CEE|rcsb pdb:7CEG|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:Gw7lb80nZihiPKBscpj115Zsldo10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q69ZK9	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-775065|uniprotkb:Q5F288|ensembl:ENSMUSP00000053097|ensembl:ENSMUSP00000104274	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:nlgn2_mouse(display_long)|uniprotkb:Nlgn2(gene name)|psi-mi:Nlgn2(display_short)|uniprotkb:Kiaa1366(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_942562.2|refseq:XP_006532964.1|dip:DIP-29702N|ensembl:ENSMUSG00000051790(gene)|ensembl:ENSMUST00000056484(transcript)|ensembl:ENSMUST00000108634(transcript)|go:"GO:0001966"(thigmotaxis)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007630"(jump response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035176"(social behavior)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0072553"(terminal button organization)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1904034"(positive regulation of t-SNARE clustering)|go:"GO:1904862"(inhibitory synapse assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030023|mint:Q69ZK9|rcsb pdb:3BL8|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:cSlsVbBCCXq2FW64Fa2J4b6apfA10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8R4I7	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2314926|uniprotkb:Q80X39|uniprotkb:Q8C4S3|uniprotkb:Q8CCM2|ensembl:ENSMUSP00000057340	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:neto1_mouse(display_long)|uniprotkb:Neto1(gene name)|psi-mi:Neto1(display_short)|uniprotkb:Btcl1(gene name synonym)|uniprotkb:Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_659195.3|refseq:XP_006526543.1|refseq:XP_006526544.1|refseq:XP_006526545.1|refseq:XP_017173396.1|refseq:XP_017173397.1|dip:DIP-48395N|ensembl:ENSMUSG00000050321(gene)|ensembl:ENSMUST00000058829(transcript)|go:"GO:0007613"(memory)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0060076"(excitatory synapse)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000312"(regulation of kainate selective glutamate receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000859(CUB)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR023415|interpro:IPR028867|interpro:IPR035914|interpro:IPR036055	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:wUdJM0aEQUXAGqKbe1hgsLWE5XQ10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P08551	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-445199|uniprotkb:Q8K0Z0|ensembl:ENSMUSP00000022639	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:nfl_mouse(display_long)|uniprotkb:Neurofilament triplet L protein(gene name synonym)|uniprotkb:68 kDa neurofilament protein(gene name synonym)|uniprotkb:Nefl(gene name)|psi-mi:Nefl(display_short)|uniprotkb:Nfl(gene name synonym)|uniprotkb:Nf68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_035040.1|ensembl:ENSMUSG00000022055(gene)|ensembl:ENSMUST00000022639(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027692|interpro:IPR039008|mint:P08551|reactome:R-MMU-438066|reactome:R-MMU-5673001|go:"GO:0098981"(cholinergic synapse)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0040011"(locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051258"(protein polymerization)|go:"GO:0051412"(response to corticosterone)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060074"(synapse maturation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|dip:DIP-31944N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:E8KK2ppZXyLXIlFZp/pjXv7GBEU10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P28660	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P13595	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-774943|uniprotkb:Q61949|uniprotkb:Q61950|intact:EBI-1018667|uniprotkb:P13594|uniprotkb:Q6LBU8|uniprotkb:Q8BQ96|uniprotkb:Q8C4B2|uniprotkb:Q921P2|uniprotkb:Q9R2A7	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ncam1_mouse(display_long)|uniprotkb:Ncam1(gene name)|psi-mi:Ncam1(display_short)|uniprotkb:Ncam(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001074914.1|refseq:NP_001106675.1|refseq:NP_035005.2|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR009138(Neural cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|refseq:NP_001297994.1|interpro:IPR033019|interpro:IPR036116|interpro:IPR036179|mint:P13595|go:"GO:0001928"(regulation of exocyst assembly)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0019902"(phosphatase binding)|go:"GO:0021794"(thalamus development)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0048666"(neuron development)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2001260"(regulation of semaphorin-plexin signaling pathway)|rcsb pdb:2NCM|rcsb pdb:3NCM|reactome:R-MMU-375165|reactome:R-MMU-419037|reactome:R-MMU-445144|reactome:R-MMU-5673001	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:bEVNNXNFliR5XooeBmVJ5PgeNwc10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9EPN1	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-527731|uniprotkb:Q8C931|uniprotkb:Q9EPM9|uniprotkb:Q9EPN0|uniprotkb:Q9WVM9|ensembl:ENSMUSP00000029374	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:nbea_mouse(display_long)|uniprotkb:Lysosomal-trafficking regulator 2(gene name synonym)|uniprotkb:Nbea(gene name)|psi-mi:Nbea(display_short)|uniprotkb:Lyst2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_085098.1|ensembl:ENSMUSG00000027799(gene)|ensembl:ENSMUST00000029374(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0008104"(protein localization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR010508(Protein of unknown function DUF1088)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023362|interpro:IPR031570|interpro:IPR036322|interpro:IPR036372|mint:Q9EPN1|refseq:XP_006501586.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:NWSzMiK/aQ6zHqkCxAoWJSqnrvA10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P63085	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9QXZ0	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-643248|intact:EBI-2658096|uniprotkb:B1ARU3|uniprotkb:Q4PLL5|uniprotkb:P97394|uniprotkb:P97395|uniprotkb:P97396	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:macf1_mouse(display_long)|uniprotkb:Actin cross-linking family 7(gene name synonym)|uniprotkb:Macf1(gene name)|psi-mi:Macf1(display_short)|uniprotkb:Acf7(gene name synonym)|uniprotkb:Aclp7(gene name synonym)|uniprotkb:Macf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR002017(Spectrin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR001101(Plectin repeat)|interpro:IPR018159|interpro:IPR001452(Src homology-3)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0008104"(protein localization)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|mint:Q9QXZ0|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:niJxpkI45VTa5x73A1tuX/aLXgo10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q91ZX7	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-300955|uniprotkb:Q61291|uniprotkb:Q920Y4	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:lrp1_mouse(display_long)|uniprotkb:Lrp1(gene name)|psi-mi:Lrp1(display_short)|uniprotkb:Alpha-2-macroglobulin receptor(gene name synonym)|uniprotkb:A2mr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	mint:Q91ZX7|go:"GO:0002020"(protease binding)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016964"(alpha-2 macroglobulin receptor activity)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032370"(positive regulation of lipid transport)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904300"(positive regulation of transcytosis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR032485|interpro:IPR036055|reactome:R-MMU-2168880|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048694"(positive regulation of collateral sprouting of injured axon)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0045807"(positive regulation of endocytosis)|reactome:R-MMU-975634|refseq:NP_032538.2|dip:DIP-47785N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:lX7IFHEMgDZnvC069QGK9D4BL1Y10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9JIA1	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-445256|ensembl:ENSMUSP00000143128	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:lgi1_mouse(display_long)|uniprotkb:Lgi1(gene name)|psi-mi:Lgi1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_064674.1|ensembl:ENSMUSG00000067242(gene)|ensembl:ENSMUST00000198518(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007411"(axon guidance)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031175"(neuron projection development)|go:"GO:0043083"(synaptic cleft)|go:"GO:0045202"(synapse)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005492(EPTP)|interpro:IPR009039(EAR)|interpro:IPR032675|mint:Q9JIA1|reactome:R-MMU-5682910	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:PEM1comV+IMxsMdEb0dRsl2+pqg10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P52189	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2309692	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kcnj4_mouse(display_long)|uniprotkb:Kcnj4(gene name)|psi-mi:Kcnj4(display_short)|uniprotkb:Irk3(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 4(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir2.3"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR003273(Potassium channel, inwardly rectifying, Kir2.3)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR040445|interpro:IPR041647|reactome:R-MMU-1296041|reactome:R-MMU-1296053|reactome:R-MMU-5576886|reactome:R-MMU-997272|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:o71idIrcU8IP7uaiSD/QJ/1NiBk10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9Z307	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2309675|uniprotkb:Q8BH37|ensembl:ENSMUSP00000102246|ensembl:ENSMUSP00000102247|ensembl:ENSMUSP00000136382|ensembl:ENSMUSP00000137414	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kcj16_mouse(display_long)|uniprotkb:Kcnj16(gene name)|psi-mi:Kcnj16(display_short)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 16(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir5.1"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001239136.1|refseq:NP_001239137.1|refseq:NP_001239138.1|refseq:NP_001239139.1|refseq:NP_034734.3|ensembl:ENSMUSG00000051497(gene)|ensembl:ENSMUST00000106635(transcript)|ensembl:ENSMUST00000106636(transcript)|ensembl:ENSMUST00000178798(transcript)|ensembl:ENSMUST00000180023(transcript)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006885"(regulation of pH)|go:"GO:0010037"(response to carbon dioxide)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR008061(Potassium channel, inwardly rectifying, Kir5)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|reactome:R-MMU-1296041|reactome:R-MMU-1296067|reactome:R-MMU-997272	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:WGRDuqZEkN33lG9jsqEPKKlY4JM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9JM63	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2309655|ensembl:ENSMUSP00000054356	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kcj10_mouse(display_long)|uniprotkb:Kcnj10(gene name)|psi-mi:Kcnj10(display_short)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 10(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir4.1"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001034573.1|refseq:XP_006496740.2|ensembl:ENSMUSG00000044708(gene)|ensembl:ENSMUST00000056136(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0044297"(cell body)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051935"(glutamate reuptake)|go:"GO:0051938"(L-glutamate import)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097546"(ciliary base)|go:"GO:0098793"(presynapse)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR003269(Potassium channel, inwardly rectifying, Kir1.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:Q9JM63|reactome:R-MMU-1296041|reactome:R-MMU-1296067|reactome:R-MMU-997272	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:xYsrr3gfPI6Dob9k78XGFz3Pp2410090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P62482	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-771096|uniprotkb:P97381|uniprotkb:Q60942|uniprotkb:Q64284|ensembl:ENSMUSP00000101273|ensembl:ENSMUSP00000125058	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kcab2_mouse(display_long)|uniprotkb:"K(+) channel subunit beta-2"(gene name synonym)|uniprotkb:Kv-beta-2(gene name synonym)|uniprotkb:Neuroimmune protein F5(gene name synonym)|uniprotkb:Kcnab2(gene name)|psi-mi:Kcnab2(display_short)|uniprotkb:Ckbeta2(gene name synonym)|uniprotkb:I2rf5(gene name synonym)|uniprotkb:Kcnb3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_034728.2|refseq:XP_017175485.1|refseq:NP_001239585.1|ensembl:ENSMUSG00000028931(gene)|ensembl:ENSMUST00000105648(transcript)|ensembl:ENSMUST00000160884(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004033"("aldo-keto reductase (NADP) activity")|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0030424"(axon)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034705"(potassium channel complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|go:"GO:0050905"(neuromuscular process)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0098900"(regulation of action potential)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1990031"(pinceau fiber)|go:"GO:2000008"(regulation of protein localization to cell surface)|interpro:IPR005399(Potassium channel, voltage-dependent, beta subunit, KCNAB-related)|interpro:IPR005401(Potassium channel, voltage-dependent, beta subunit, KCNAB2)|interpro:IPR005983(Potassium channel, voltage-dependent, beta subunit, KCNAB)|interpro:IPR023210|interpro:IPR036812|mint:P62482|reactome:R-MMU-1296072|reactome:R-MMU-6798695	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:ZWu/Ez0ginUniSAUbIGXgod3iqg10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P63143	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2311348|uniprotkb:Q91WM5|uniprotkb:P97380|uniprotkb:Q61763|uniprotkb:Q63277|ensembl:ENSMUSP00000047480	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kcab1_mouse(display_long)|uniprotkb:Kcnab1(gene name)|psi-mi:Kcnab1(display_short)|uniprotkb:Kvb1(gene name synonym)|uniprotkb:"K(+) channel subunit beta-1"(gene name synonym)|uniprotkb:Kv-beta-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_034727.3|ensembl:ENSMUSG00000027827(gene)|ensembl:ENSMUST00000049230(transcript)|go:"GO:0004033"("aldo-keto reductase (NADP) activity")|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007611"(learning or memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034705"(potassium channel complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|go:"GO:0070402"(NADPH binding)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1903817"(negative regulation of voltage-gated potassium channel activity)|go:"GO:1990635"(proximal dendrite)|interpro:IPR005399(Potassium channel, voltage-dependent, beta subunit, KCNAB-related)|interpro:IPR005400(Potassium channel, voltage-dependent, beta subunit, KCNAB1)|interpro:IPR005983(Potassium channel, voltage-dependent, beta subunit, KCNAB)|interpro:IPR023210|interpro:IPR036812|reactome:R-MMU-1296072	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:795ewCikN88RrzXAcw5WB7Jv4qI10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q61423	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2309633|uniprotkb:Q8CBF8|ensembl:ENSMUSP00000037958	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kcna4_mouse(display_long)|uniprotkb:Kcna4(gene name)|psi-mi:Kcna4(display_short)|uniprotkb:Voltage-gated potassium channel subunit Kv1.4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_067250.2|refseq:XP_006498875.1|ensembl:ENSMUSG00000042604(gene)|ensembl:ENSMUST00000037012(transcript)|go:"GO:0005216"(ion channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR012897(Potassium channel, voltage dependent, Kv1.4, tandem inactivation)|interpro:IPR020467|interpro:IPR027359|interpro:IPR028325|interpro:IPR037065|reactome:R-MMU-1296072	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:kLzL2QUiIqbJX3FwQ8RNPL9rxac10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P16390	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2309612|uniprotkb:A3KMM2|ensembl:ENSMUSP00000050680	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kcna3_mouse(display_long)|uniprotkb:Kcna3(gene name)|psi-mi:Kcna3(display_short)|uniprotkb:Voltage-gated potassium channel subunit Kv1.3(gene name synonym)|uniprotkb:MK3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032444.2|ensembl:ENSMUSG00000047959(gene)|ensembl:ENSMUST00000052718(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004050(Potassium channel, voltage dependent, Kv1.3)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|reactome:R-MMU-1296072	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:geKuqjBN25rHCIenRhqe0zsZB3M10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P63141	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-644033|uniprotkb:P15386|uniprotkb:Q02010|uniprotkb:Q8C8W4|uniprotkb:B2RS05|ensembl:ENSMUSP00000041702|ensembl:ENSMUSP00000142873|ensembl:ENSMUSP00000143798	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kcna2_mouse(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.2(gene name synonym)|uniprotkb:Kcna2(gene name)|psi-mi:Kcna2(display_short)|uniprotkb:MK2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032443.3|ensembl:ENSMUSG00000040724(gene)|ensembl:ENSMUST00000038695(transcript)|ensembl:ENSMUST00000196403(transcript)|ensembl:ENSMUST00000197470(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019894"(kinesin binding)|go:"GO:0021633"(optic nerve structural organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033010"(paranodal junction)|go:"GO:0034705"(potassium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044305"(calyx of Held)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004049(Potassium channel, voltage dependent, Kv1.2)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|rcsb pdb:5WIE|reactome:R-MMU-1296072|refseq:XP_006501113.1|refseq:XP_006501114.1|refseq:XP_006501111.1|refseq:XP_006501112.1|refseq:XP_006501115.1|refseq:XP_006501116.1|refseq:XP_006501117.1|refseq:XP_006501118.1|dip:DIP-32239N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:AimFojHr+yjzzdtmfxUCRBTvJyc10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P16388	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2309589|ensembl:ENSMUSP00000055225|ensembl:ENSMUSP00000144947	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kcna1_mouse(display_long)|uniprotkb:Kcna1(gene name)|psi-mi:Kcna1(display_short)|uniprotkb:Voltage-gated potassium channel subunit Kv1.1(gene name synonym)|uniprotkb:MKI(gene name synonym)|uniprotkb:MBK1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_034725.3|ensembl:ENSMUSG00000047976(gene)|ensembl:ENSMUST00000055168(transcript)|ensembl:ENSMUST00000203094(transcript)|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0021766"(hippocampus development)|go:"GO:0023041"(neuronal signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034705"(potassium channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044305"(calyx of Held)|go:"GO:0045202"(synapse)|go:"GO:0050905"(neuromuscular process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050976"(detection of mechanical stimulus involved in sensory perception of touch)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099508"(voltage-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|go:"GO:1905030"(voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004048(Potassium channel, voltage dependent, Kv1.1)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|mint:P16388|reactome:R-MMU-1296072|go:"GO:0034613"(cellular protein localization)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:jWMZN1sE3o5n4oah+dtPVzhAJPk10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:A2CG49	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-770321|uniprotkb:A2CG50|uniprotkb:A2CG51|uniprotkb:A2CG52|uniprotkb:A2CG53|uniprotkb:Q3TYL1|uniprotkb:Q3UTA5|uniprotkb:Q8BTT9|uniprotkb:Q8C4Q2|uniprotkb:Q9CVA9|uniprotkb:Q3TXY8|uniprotkb:B2RXR5|uniprotkb:D3Z559|ensembl:ENSMUSP00000076088	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kalrn_mouse(display_long)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001157740.1|refseq:XP_006522445.1|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018159|interpro:IPR028570|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSMUSG00000061751(gene)|ensembl:ENSMUST00000076810(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0035176"(social behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042711"(maternal behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046959"(habituation)|mint:A2CG49|rcsb pdb:1WFW|reactome:R-MMU-193648|reactome:R-MMU-3928662|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5687128|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013408|interpro:IPR036865	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:pDqdA2QNbqgLE3eYQXVVW2cxIyo10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q5DU25	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-773452|uniprotkb:E9QK46	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:iqec2_mouse(display_long)|uniprotkb:Iqsec2(gene name)|psi-mi:Iqsec2(display_short)|uniprotkb:Kiaa0522(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000904(SEC7-like)|interpro:IPR023394|interpro:IPR033742|refseq:XP_006528908.1|interpro:IPR035999|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900454"(positive regulation of long-term synaptic depression)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:D2kDV/pgwPkXPHcK5+7S9+HS6Wk10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8R0S2	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-772277|uniprotkb:Q3TZC3|uniprotkb:Q5DU15|ensembl:ENSMUSP00000098712	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:iqec1_mouse(display_long)|uniprotkb:Iqsec1(gene name)|psi-mi:Iqsec1(display_short)|uniprotkb:Kiaa0763(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001127855.1|ensembl:ENSMUSG00000034312(gene)|ensembl:ENSMUST00000101153(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR030737|interpro:IPR033742|interpro:IPR035999	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:BZg7CaLndE4ak8KXs34YFf9iBRQ10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9QYS2	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-770623|uniprotkb:Q14DJ9|ensembl:ENSMUSP00000004076	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:grm3_mouse(display_long)|uniprotkb:Gprc1c(gene name synonym)|uniprotkb:Mglur3(gene name synonym)|uniprotkb:Grm3(gene name)|psi-mi:Grm3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_862898.1|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0010467"(gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|ensembl:ENSMUSG00000003974(gene)|ensembl:ENSMUST00000004076(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001234(GPCR, family 3, metabotropic glutamate receptor 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:Q9QYS2|reactome:R-MMU-418594|reactome:R-MMU-420499	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:6YCf0CVHHO8OR8GpAMxCucRLxJE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q03391	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2309422|uniprotkb:C9K0Z5|ensembl:ENSMUSP00000002848|ensembl:ENSMUSP00000147663	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:nmde4_mouse(display_long)|uniprotkb:Grin2d(gene name)|psi-mi:Grin2d(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2D(gene name synonym)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-4(gene name synonym)|uniprotkb:GluN2D(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:XP_011249107.1|refseq:NP_032198.2|ensembl:ENSMUSG00000002771(gene)|ensembl:ENSMUST00000002848(transcript)|ensembl:ENSMUST00000211713(transcript)|go:"GO:0001964"(startle response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0045202"(synapse)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:Q03391|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:SJwi1VKUdtgh3l6xcUxHm/57loU10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q01097	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-400125|uniprotkb:Q9DCB2	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P35436	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-400115|ensembl:ENSMUSP00000032331|ensembl:ENSMUSP00000111501|ensembl:ENSMUSP00000142900	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:nmde1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:Grin2a(gene name)|psi-mi:Grin2a(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032196.2|reactome:R-MMU-8849932|reactome:R-MMU-9609736|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-438066|go:"GO:0098839"(postsynaptic density membrane)|ensembl:ENSMUSG00000059003(gene)|ensembl:ENSMUST00000032331(transcript)|ensembl:ENSMUST00000115835(transcript)|ensembl:ENSMUST00000199708(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040011"(locomotion)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|refseq:XP_006521857.1|dip:DIP-31567N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:5DMFDOh6NuFArDtKp2gp2IpmhWQ10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P35438	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q61626	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2311175|uniprotkb:G5E822|ensembl:ENSMUSP00000003468	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:grik5_mouse(display_long)|uniprotkb:Grik5(gene name)|psi-mi:Grik5(display_short)|uniprotkb:Glutamate receptor KA-2(gene name synonym)|uniprotkb:Glutamate receptor gamma-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032194.2|ensembl:ENSMUSG00000003378(gene)|ensembl:ENSMUST00000003468(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031630"(regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051649"(establishment of localization in cell)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-451308	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:ZuWV7C0m5w51dQbyp2GLH4n2D/810090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P39087	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-396914|uniprotkb:Q60933|ensembl:ENSMUSP00000101124|ensembl:ENSMUSP00000151921	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:grik2_mouse(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)|uniprotkb:Glutamate receptor beta-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:XP_017169293.1|ensembl:ENSMUSG00000056073(gene)|ensembl:ENSMUST00000105484(transcript)|ensembl:ENSMUST00000218823(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:P39087|reactome:R-MMU-451307|reactome:R-MMU-451308	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:6sgY8SzX07HzilLLeDg3pV+sXkc10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9Z2W8	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-445497|uniprotkb:Q6P9M7|ensembl:ENSMUSP00000066980	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:gria4_mouse(display_long)|uniprotkb:GluR-D(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 4(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 4(gene name synonym)|uniprotkb:Gria4(gene name)|psi-mi:Gria4(display_short)|uniprotkb:Glur4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001106651.1|refseq:NP_001106652.1|refseq:NP_062665.3|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-399710|reactome:R-MMU-399719|reactome:R-MMU-416993|reactome:R-MMU-438066|reactome:R-MMU-8849932|ensembl:ENSMUST00000063508(transcript)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|ensembl:ENSMUSG00000025892(gene)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:c8dAAqu5FPt6QuBSXPdJXnBRlV410090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9Z2W9	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-445507|uniprotkb:A2VDF4|uniprotkb:Q5DTJ0|ensembl:ENSMUSP00000075687	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:gria3_mouse(display_long)|uniprotkb:GluR-K3(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 3(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 3(gene name synonym)|uniprotkb:Gria3(gene name)|psi-mi:Gria3(display_short)|uniprotkb:Kiaa4184(gene name synonym)|uniprotkb:Glur3(gene name synonym)|uniprotkb:GluR-C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_058582.3|refseq:XP_006541583.1|refseq:NP_001268858.1|refseq:XP_017174034.1|ensembl:ENSMUSG00000001986(gene)|ensembl:ENSMUST00000076349(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032991"(protein-containing complex)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|go:"GO:0038023"(signaling receptor activity)|interpro:IPR028082|go:"GO:0043025"(neuronal cell body)|mint:Q9Z2W9|rcsb pdb:3LSW|rcsb pdb:3LSX|go:"GO:0043083"(synaptic cleft)|reactome:R-MMU-399710|reactome:R-MMU-399719|reactome:R-MMU-416993|go:"GO:0043195"(terminal bouton)|reactome:R-MMU-438066|go:"GO:0043197"(dendritic spine)|reactome:R-MMU-8849932|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:n9Lnq/kl4co4Th5d/N5JX+cN4yU10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P23819	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-77538|uniprotkb:Q61604|uniprotkb:Q61605|uniprotkb:Q8BG69|uniprotkb:Q8BXU3|uniprotkb:Q9D6D3	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:gria2_mouse(display_long)|uniprotkb:Gria2(gene name)|psi-mi:Gria2(display_short)|uniprotkb:Glur2(gene name synonym)|uniprotkb:GluR-B(gene name synonym)|uniprotkb:GluR-K2(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 2(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051117"(ATPase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|reactome:R-MMU-399710|reactome:R-MMU-416993|reactome:R-MMU-438066|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR028082|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|mint:P23819	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:v71xzThz9kadLOPBasVAc1y/FXs10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P23818	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-445486|ensembl:ENSMUSP00000044494	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:gria1_mouse(display_long)|uniprotkb:GluR-A(gene name synonym)|uniprotkb:GluR-K1(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 1(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 1(gene name synonym)|uniprotkb:Gria1(gene name)|psi-mi:Gria1(display_short)|uniprotkb:Glur1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001106796.1|dip:DIP-31970N|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044297"(cell body)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060076"(excitatory synapse)|go:"GO:0045202"(synapse)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:7LDD|rcsb pdb:7LDE|reactome:R-MMU-204005|reactome:R-MMU-399710|reactome:R-MMU-399719|reactome:R-MMU-416993|ensembl:ENSMUSG00000020524(gene)|ensembl:ENSMUST00000036315(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|reactome:R-MMU-438066|reactome:R-MMU-5694530|reactome:R-MMU-8849932	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:5hAcAV1UEfdgn7CNrrAHPIwUs/410090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8C4G9	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-16724519|ensembl:ENSMUSP00000026548|uniprotkb:Q8CC05	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:agra1_mouse(display_long)|uniprotkb:G-protein coupled receptor 123(gene name synonym)|uniprotkb:Adgra1(gene name)|psi-mi:Adgra1(display_short)|uniprotkb:Gpr123(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000025475(gene)|ensembl:ENSMUST00000026548(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR017981|interpro:IPR017983|refseq:NP_803420.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:FAmBtBtHGDbO73BEzhrgeNxT1ks10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P35802	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-774131|ensembl:ENSMUSP00000033915	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:gpm6a_mouse(display_long)|uniprotkb:Gpm6a(gene name)|psi-mi:Gpm6a(display_short)|uniprotkb:M6a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001240683.1|refseq:NP_001240685.1|refseq:NP_705809.1|ensembl:ENSMUSG00000031517(gene)|ensembl:ENSMUST00000033915(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0003407"(neural retina development)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0030175"(filopodium)|go:"GO:0031175"(neuron projection development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001614(Myelin proteolipid protein PLP)|interpro:IPR018237|mint:P35802	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:VjNJpPICJnWhRvbITEMlwqYYedE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P62874	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-357152|ensembl:ENSMUSP00000030940|ensembl:ENSMUSP00000101241|ensembl:ENSMUSP00000130123|ensembl:ENSMUSP00000135091|uniprotkb:P04901|uniprotkb:P04697	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:gbb1_mouse(display_long)|uniprotkb:Gnb1(gene name)|psi-mi:Gnb1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000029064(gene)|ensembl:ENSMUST00000030940(transcript)|ensembl:ENSMUST00000105616(transcript)|ensembl:ENSMUST00000165335(transcript)|ensembl:ENSMUST00000176637(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007603"(phototransduction, visible light)|reactome:R-MMU-9009391|reactome:R-MMU-997272|reactome:R-MMU-8964616|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030425"(dendrite)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043209"(myelin sheath)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62874|rcsb pdb:6K41|rcsb pdb:6K42|rcsb pdb:6RMV|reactome:R-MMU-1296041|reactome:R-MMU-202040|reactome:R-MMU-2485179|reactome:R-MMU-381676|reactome:R-MMU-381753|reactome:R-MMU-392170|reactome:R-MMU-392451|reactome:R-MMU-392851|reactome:R-MMU-400042|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418217|reactome:R-MMU-418555|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418597|reactome:R-MMU-420092|reactome:R-MMU-428930|reactome:R-MMU-432040|reactome:R-MMU-456926|reactome:R-MMU-500657|reactome:R-MMU-6814122|reactome:R-MMU-8964315|refseq:NP_001153488.1|refseq:NP_001153489.1|refseq:NP_032168.1|refseq:XP_017175466.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:zP/G70MXiSQpzbyyWFTWrJFQENk10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P18872	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-771950|uniprotkb:P18873|intact:EBI-1018769|ensembl:ENSMUSP00000034198|ensembl:ENSMUSP00000114144	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:gnao_mouse(display_long)|uniprotkb:Gnao1(gene name)|psi-mi:Gnao1(display_short)|uniprotkb:Gna0(gene name synonym)|uniprotkb:Gnao(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001106855.1|refseq:NP_034438.1|dip:DIP-29921N|ensembl:ENSMUSG00000031748(gene)|ensembl:ENSMUST00000034198(transcript)|ensembl:ENSMUST00000125716(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009987"(cellular process)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P18872|rcsb pdb:3C7K|reactome:R-MMU-4086398	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:CCww9l5owYxGicswRXjsSu6Y+5g10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:B2RSH2	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2308910|ensembl:ENSMUSP00000074259	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:gnai1_mouse(display_long)|uniprotkb:Gnai1(gene name)|psi-mi:Gnai1(display_short)|uniprotkb:Gnai-1(gene name synonym)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_034435.1|ensembl:ENSMUSG00000057614(gene)|ensembl:ENSMUST00000074694(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0099738"(cell cortex region)|go:"GO:1904322"(cellular response to forskolin)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-MMU-170670|reactome:R-MMU-392170|reactome:R-MMU-400042|reactome:R-MMU-418594|reactome:R-MMU-9009391	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:3yQOCXJb8Undp/Xw42xrBiG5ePE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P15105	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-444858|uniprotkb:Q3TRK7|uniprotkb:Q64432|uniprotkb:Q91VC6|ensembl:ENSMUSP00000083375|ensembl:ENSMUSP00000123157	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:glna_mouse(display_long)|uniprotkb:Glutamate--ammonia ligase(gene name synonym)|uniprotkb:Glul(gene name)|psi-mi:Glul(display_short)|uniprotkb:Glns(gene name synonym)|uniprotkb:Palmitoyltransferase GLUL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032157.2|go:"GO:0030145"(manganese ion binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0097386"(glial cell projection)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR008146(Glutamine synthetase, catalytic region)|interpro:IPR008147(Glutamine synthetase, beta-Grasp)|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR027302|interpro:IPR027303|interpro:IPR036651|mint:P15105|reactome:R-MMU-210455|reactome:R-MMU-8964539|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|ensembl:ENSMUSG00000026473(gene)|ensembl:ENSMUST00000086199(transcript)|ensembl:ENSMUST00000140685(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0004356"(glutamate-ammonia ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006542"(glutamine biosynthetic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0016595"(glutamate binding)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019676"(ammonia assimilation cycle)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:j6R9fxGLKpiREWpecpdnBY9ftoo10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q61598	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-6665490|ensembl:ENSMUSP00000152454|uniprotkb:Q541Z9|uniprotkb:Q8C530|uniprotkb:Q9D8M9	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:gdib_mouse(display_long)|uniprotkb:Gdi2(gene name)|psi-mi:Gdi2(display_short)|uniprotkb:Gdi3(gene name synonym)|uniprotkb:GDI-3(gene name synonym)|uniprotkb:Guanosine diphosphate dissociation inhibitor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:Q61598|reactome:R-MMU-6798695|reactome:R-MMU-8876198|ensembl:ENSMUSG00000021218(gene)|ensembl:ENSMUST00000223396(transcript)|refseq:NP_032138.3|dip:DIP-348N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:+ngZz9q02lDEdFO543w/yl6chgc10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P50396	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-1634930|uniprotkb:A2AMA8|uniprotkb:Q3TBI9|uniprotkb:Q8VHM3|uniprotkb:Q91Y71|uniprotkb:Q91Z41|uniprotkb:Q96CX5|ensembl:ENSMUSP00000015435	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:gdia_mouse(display_long)|uniprotkb:Gdi1(gene name)|psi-mi:Gdi1(display_short)|uniprotkb:Rabgdia(gene name synonym)|uniprotkb:Guanosine diphosphate dissociation inhibitor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000015291(gene)|ensembl:ENSMUST00000015435(transcript)|go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|refseq:NP_034403.1|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:P50396|reactome:R-MMU-8876198|go:"GO:0043209"(myelin sheath)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:PedrlfCE1ZCgXPtL9PZmNfOoxdo10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9R111	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2308876|ensembl:ENSMUSP00000084882	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:guad_mouse(display_long)|uniprotkb:Gda(gene name)|psi-mi:Gda(display_short)|uniprotkb:Guanine aminohydrolase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_034396.1|ensembl:ENSMUSG00000058624(gene)|ensembl:ENSMUST00000087600(transcript)|go:"GO:0000255"(allantoin metabolic process)|go:"GO:0005829"(cytosol)|go:"GO:0006147"(guanine catabolic process)|go:"GO:0006161"(deoxyguanosine catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008892"(guanine deaminase activity)|go:"GO:0019239"(deaminase activity)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0046055"(dGMP catabolic process)|go:"GO:0046098"(guanine metabolic process)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR014311(Guanine deaminase)|interpro:IPR032466|mint:Q9R111|reactome:R-MMU-74259|go:"GO:0046038"(GMP catabolic process)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:4GljtxkNduzgstV1OX/vkPJ/Qvg10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q61553	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2308857|uniprotkb:O09099|uniprotkb:O09156|uniprotkb:Q05DK3|uniprotkb:Q7TN32|uniprotkb:Q80V75|ensembl:ENSMUSP00000031565	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:fscn1_mouse(display_long)|uniprotkb:Fscn1(gene name)|psi-mi:Fscn1(display_short)|uniprotkb:Fan1(gene name synonym)|uniprotkb:Snl(gene name synonym)|uniprotkb:Singed-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032010.2|dip:DIP-54657N|ensembl:ENSMUSG00000029581(gene)|ensembl:ENSMUST00000031565(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044393"(microspike)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|interpro:IPR008999(Actin_cross-linking)|interpro:IPR010431(Fascin)|interpro:IPR022768|interpro:IPR024703|interpro:IPR030146|mint:Q61553	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:D+qdiRYJCXobCuZmdebrhb32jSI10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:A0A140LIW3	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-16724497|ensembl:ENSMUSP00000146983	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:a0a140liw3_mouse(display_long)|uniprotkb:Frmpd3(gene name)|psi-mi:Frmpd3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000042425(gene)|ensembl:ENSMUST00000208130(transcript)|go:"GO:0005856"(cytoskeleton)|interpro:IPR000159(Ras-association)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041779|reactome:R-MMU-6798695|refseq:NP_001307875.1|refseq:XP_017173990.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:Vzfrptm2IU2XJuVT8TWMY0AlUA810090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q3UXZ6	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2308826|uniprotkb:Q8BQV1|uniprotkb:Q8C548|uniprotkb:Q8R3B5|uniprotkb:Q9D369|ensembl:ENSMUSP00000034749	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:fa81a_mouse(display_long)|uniprotkb:Fam81a(gene name)|psi-mi:Fam81a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_084060.1|refseq:XP_006511613.1|refseq:XP_006511614.1|ensembl:ENSMUSG00000032224(gene)|ensembl:ENSMUST00000034749(transcript)|interpro:IPR029619|interpro:IPR029622	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:B2gqwbO+APP0oh2e0om4bCpv7UM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P17182	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-299507|ensembl:ENSMUSP00000075513|ensembl:ENSMUSP00000079727|ensembl:ENSMUSP00000157807|uniprotkb:Q99KT7|uniprotkb:Q9DCY7	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:enoa_mouse(display_long)|uniprotkb:Eno1(gene name)|psi-mi:Eno1(display_short)|uniprotkb:Eno-1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000059040(gene)|ensembl:ENSMUSG00000063524(gene)|ensembl:ENSMUST00000076155(transcript)|ensembl:ENSMUST00000080926(transcript)|ensembl:ENSMUST00000235307(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030426"(growth cone)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051020"(GTPase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0099738"(cell cortex region)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P17182|reactome:R-MMU-70171|reactome:R-MMU-70263|refseq:NP_001020559.1|refseq:NP_075608.2|refseq:XP_006538588.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:YFpn/7GDB6vXgCYLSxvNns7FlT410090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P10126	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-773865|uniprotkb:Q61511|uniprotkb:Q6ZWN2|uniprotkb:Q8BMB8|uniprotkb:Q8BVS8|uniprotkb:Q99KU5|ensembl:ENSMUSP00000042457	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ef1a1_mouse(display_long)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Eef1a1(gene name)|psi-mi:Eef1a1(display_short)|uniprotkb:Eef1a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	dip:DIP-46609N|refseq:NP_034236.2|ensembl:ENSMUSG00000037742(gene)|ensembl:ENSMUST00000042235(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P10126|reactome:R-MMU-156842|reactome:R-MMU-3371511|reactome:R-MMU-6798695|reactome:R-MMU-8876725	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:85G9Uje743KzA02bB/rmKuq2HbU10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9R0P5	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-1184008|ensembl:ENSMUSP00000099461	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dest_mouse(display_long)|uniprotkb:Dstn(gene name)|psi-mi:Dstn(display_short)|uniprotkb:Dsn(gene name synonym)|uniprotkb:Sid23(gene name synonym)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Sid 23(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_062745.1|ensembl:ENSMUSG00000015932(gene)|ensembl:ENSMUST00000103172(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR029006|interpro:IPR029924|mint:Q9R0P5	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:hqPae8VWEKvGPITqHtrSs78yI4M10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:B1AZP2	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-645637|uniprotkb:B1AZP3|uniprotkb:Q3KQQ8|uniprotkb:Q6PD44|uniprotkb:Q6XBF1|uniprotkb:Q80TN3|uniprotkb:Q8R3U9|uniprotkb:B7ZNS1|ensembl:ENSMUSP00000126980	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dlgp4_mouse(display_long)|uniprotkb:Kiaa0964(gene name synonym)|uniprotkb:Sapap4(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 4(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 4(gene name synonym)|uniprotkb:Dlgap4(gene name)|psi-mi:Dlgap4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001035952.1|refseq:NP_666240.4|refseq:NP_001264115.1|refseq:NP_001035953.1|refseq:NP_001264116.1|refseq:XP_006499403.1|ensembl:ENSMUSG00000061689(gene)|ensembl:ENSMUST00000169464(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023052"(signaling)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030527|mint:B1AZP2|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:Ksjp5jiwjvzSymdyt1kSs8I+1pE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q6PFD5	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2308733|uniprotkb:Q6PDX0|uniprotkb:Q6XBF2|ensembl:ENSMUSP00000039724|ensembl:ENSMUSP00000101700	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dlgp3_mouse(display_long)|uniprotkb:Dlgap3(gene name)|psi-mi:Dlgap3(display_short)|uniprotkb:Dap3(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 3(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:XP_011238839.1|refseq:NP_941020.1|refseq:NP_001289010.1|ensembl:ENSMUSG00000042388(gene)|ensembl:ENSMUST00000046659(transcript)|ensembl:ENSMUST00000106094(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023052"(signaling)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030526|mint:Q6PFD5|rcsb pdb:5IZU|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:mkXYwYR5Snou4RA8d71UDC7G59I10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8BJ42	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2308675|uniprotkb:Q6XBF3|ensembl:ENSMUSP00000039647|ensembl:ENSMUSP00000119613	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dlgp2_mouse(display_long)|uniprotkb:Dlgap2(gene name)|psi-mi:Dlgap2(display_short)|uniprotkb:Dap2(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 2(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001139437.1|refseq:NP_766498.2|refseq:XP_017168275.1|ensembl:ENSMUSG00000047495(gene)|ensembl:ENSMUST00000043279(transcript)|ensembl:ENSMUST00000133298(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0043197"(dendritic spine)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030525|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:9V3GlRM3AupA70mmFtZ4biXuC9E10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9D415	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P70175	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-396969|ensembl:ENSMUSP00000085299	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dlg3_mouse(display_long)|uniprotkb:Dlg3(gene name)|psi-mi:Dlg3(display_short)|uniprotkb:Dlgh3(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_058027.1|refseq:NP_001171249.1|ensembl:ENSMUSG00000000881(gene)|ensembl:ENSMUST00000087984(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|mint:P70175|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-6794361|reactome:R-MMU-8849932|dip:DIP-31585N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:9dR9P876v8QcvPinxtaWzDgpHwE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q91XM9	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-400138|uniprotkb:Q8BXK7|uniprotkb:Q8BYG5|ensembl:ENSMUSP00000102814|uniprotkb:F8VQM7	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dlg2_mouse(display_long)|uniprotkb:Dlg2(gene name)|psi-mi:Dlg2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000052572(gene)|ensembl:ENSMUST00000107196(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035759|interpro:IPR036028|interpro:IPR036034|mint:Q91XM9|rcsb pdb:2WL7|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6794361|refseq:NP_001229976.1|refseq:NP_035937.2|dip:DIP-31569N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:37/IFbjDNxh87dnN2gglIgDGyIU10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q811D0	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-514290|uniprotkb:Q62402|uniprotkb:Q6PGB5|uniprotkb:Q8CGN7|ensembl:ENSMUSP00000097581|ensembl:ENSMUSP00000110859	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dlg1_mouse(display_long)|uniprotkb:Synapse-associated protein 97(gene name synonym)|uniprotkb:Embryo-dlg/synapse-associated protein 97(gene name synonym)|uniprotkb:Dlg1(gene name)|psi-mi:Dlg1(display_short)|uniprotkb:Dlgh1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_031888.2|refseq:NP_001239362.1|refseq:NP_001239364.1|refseq:XP_006521831.1|refseq:NP_001239363.1|dip:DIP-31591N|ensembl:ENSMUSG00000022770(gene)|ensembl:ENSMUST00000100001(transcript)|ensembl:ENSMUST00000115205(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034629"|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043219"(lateral loop)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060022"(hard palate development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1902473"(regulation of protein localization to synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903286"(regulation of potassium ion import)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903760"(regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:1903764"(regulation of potassium ion export across plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR015143(L27-1)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q811D0|rcsb pdb:4OAJ|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-8849932	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:b8LjYbiuR2K6/jxhwU1hxBJKX6410090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q3UH60	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-16724475|ensembl:ENSMUSP00000097777|uniprotkb:Q8C1W5|uniprotkb:Q8CDG9|uniprotkb:Q8CHA2	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:dip2b_mouse(display_long)|uniprotkb:Dip2b(gene name)|psi-mi:Dip2b(display_short)|uniprotkb:Kiaa1463(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000023026(gene)|ensembl:ENSMUST00000100203(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR010506(DMAP1-binding)|interpro:IPR037337|interpro:IPR042099|mint:Q3UH60|refseq:NP_001152833.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:fgjJT8HpeVRm1osKj8p2Dx7WxU810090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q5SQX6	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q7TMB8	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:O54991	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-774794|uniprotkb:A2A4K6|ensembl:ENSMUSP00000099398	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:cntp1_mouse(display_long)|uniprotkb:Neurexin-4(gene name synonym)|uniprotkb:Neurexin IV(gene name synonym)|uniprotkb:Paranodin(gene name synonym)|uniprotkb:NCP1(gene name synonym)|uniprotkb:MHDNIV(gene name synonym)|uniprotkb:Cntnap1(gene name)|psi-mi:Cntnap1(display_short)|uniprotkb:Nrxn4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_058062.2|ensembl:ENSMUSG00000017167(gene)|ensembl:ENSMUST00000103109(transcript)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0005886"(plasma membrane)|go:"GO:0005918"(septate junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030424"(axon)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0033010"(paranodal junction)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR028872|interpro:IPR036056|mint:O54991	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:BTW+FjgSUq00WpWGDC6PpQcIowE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P12960	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-774808|uniprotkb:Q6NXV7|uniprotkb:Q8BR42|uniprotkb:Q8C6A0|ensembl:ENSMUSP00000000109|ensembl:ENSMUSP00000067842|ensembl:ENSMUSP00000133063	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:cntn1_mouse(display_long)|uniprotkb:Neural cell surface protein F3(gene name synonym)|uniprotkb:Cntn1(gene name)|psi-mi:Cntn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001153119.1|refseq:NP_001153120.1|refseq:NP_031753.1|refseq:XP_017171911.1|ensembl:ENSMUSG00000055022(gene)|ensembl:ENSMUST00000000109(transcript)|ensembl:ENSMUST00000068378(transcript)|ensembl:ENSMUST00000169825(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0021549"(cerebellum development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099026"(anchored component of presynaptic membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR036992|mint:P12960	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:TftNvfwJlK/7DTczqiV/IzDxhOM10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P16330	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-772515|uniprotkb:Q61424|uniprotkb:Q8C7C9|uniprotkb:Q91V42|uniprotkb:Q923F3|ensembl:ENSMUSP00000099409	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:cn37_mouse(display_long)|uniprotkb:Cnp(gene name)|psi-mi:Cnp(display_short)|uniprotkb:Cnp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001139790.1|refseq:NP_034053.2|refseq:XP_017169734.1|ensembl:ENSMUSG00000006782(gene)|ensembl:ENSMUST00000103120(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003723"(RNA binding)|go:"GO:0004113"(2',3'-cyclic-nucleotide 3'-phosphodiesterase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009214"(cyclic nucleotide catabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030551"(cyclic nucleotide binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031143"(pseudopodium)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|interpro:IPR008431(Cyclic nucleotide phosphodiesterase)|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|interpro:IPR027417|mint:P16330|rcsb pdb:2XMI|rcsb pdb:2Y1P|rcsb pdb:2Y3X|rcsb pdb:2YDB|rcsb pdb:2YDC|rcsb pdb:2YDD|rcsb pdb:2YOZ|rcsb pdb:2YP0|rcsb pdb:2YPC|rcsb pdb:2YPE|rcsb pdb:2YPH|rcsb pdb:2YQ9|rcsb pdb:3ZBR|rcsb pdb:3ZBS|rcsb pdb:3ZBZ|rcsb pdb:4WBI|rcsb pdb:4WBL|rcsb pdb:4WC9|rcsb pdb:4WCA|rcsb pdb:4WCB|rcsb pdb:4WCC|rcsb pdb:4WDA|rcsb pdb:4WDB|rcsb pdb:4WDD|rcsb pdb:4WDE|rcsb pdb:4WDF|rcsb pdb:4WDG|rcsb pdb:4WDH|rcsb pdb:4WEX|rcsb pdb:4WFR|rcsb pdb:5AE0	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:z0XniuUAwQzaZTvQmEmctKYNw9810090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q06890	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-774758|ensembl:ENSMUSP00000022616	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:clus_mouse(display_long)|uniprotkb:Sulfated glycoprotein 2(gene name synonym)|uniprotkb:Clustrin(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:Clu(gene name)|psi-mi:Clu(display_short)|uniprotkb:Apoj(gene name synonym)|uniprotkb:Msgp-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_038520.2|refseq:XP_006518567.1|ensembl:ENSMUSG00000022037(gene)|ensembl:ENSMUST00000022616(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002434"(immune complex clearance)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016235"(aggresome)|go:"GO:0017038"(protein import)|go:"GO:0030426"(growth cone)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0071944"(cell periphery)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0099020"(perinuclear endoplasmic reticulum lumen)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902847"(regulation of neuronal signal transduction)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1905892"(negative regulation of cellular response to thapsigargin)|go:"GO:1905895"(negative regulation of cellular response to tunicamycin)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000753(Clusterin-like)|interpro:IPR016014(Clusterin, N-terminal)|interpro:IPR016015(Clusterin, C-terminal)|interpro:IPR016016(Clusterin)|interpro:IPR033986|mint:Q06890|reactome:R-MMU-114608|reactome:R-MMU-166665|reactome:R-MMU-6803157|reactome:R-MMU-977606|go:"GO:0042583"(chromaffin granule)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:wP6AESslzICF3ojv9a+vJUn61VA10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q68FD5	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-769168|ensembl:ENSMUSP00000099475	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:clh1_mouse(display_long)|uniprotkb:Cltc(gene name)|psi-mi:Cltc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001003908.1|dip:DIP-31947N|ensembl:ENSMUSG00000047126(gene)|ensembl:ENSMUST00000103186(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043209"(myelin sheath)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q68FD5|rcsb pdb:5ODS|reactome:R-MMU-177504|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0032051"(clathrin light chain binding)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:iHg/TOG2rWePqtsEmuc/szn/chI10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P49025	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-397301|intact:EBI-487846|uniprotkb:O88528|uniprotkb:O88937|uniprotkb:O88938|uniprotkb:Q3UM99|uniprotkb:Q8CIJ1	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ctro_mouse(display_long)|uniprotkb:Cit(gene name)|psi-mi:Cit(display_short)|uniprotkb:Rho-interacting, serine/threonine-protein kinase 21(gene name synonym)|uniprotkb:Crik(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR017405(Citron Rho-interacting kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|refseq:XP_006530214.1|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001726"(ruffle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR037708|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005856"(cytoskeleton)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048699"(generation of neurons)|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-5625900	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:8kykadVIiyk12GjGCZNn0bQ13C010090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P18760	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-1183994|ensembl:ENSMUSP00000147514	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:cof1_mouse(display_long)|uniprotkb:Cfl1(gene name)|psi-mi:Cfl1(display_short)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_031713.1|ensembl:ENSMUSG00000056201(gene)|ensembl:ENSMUST00000209469(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001842"(neural fold formation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031252"(cell leading edge)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051511"(negative regulation of unidimensional cell growth)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090732"(cofilin-actin rod)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905873"(positive regulation of protein localization to cell leading edge)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000784"(positive regulation of establishment of cell polarity regulating cell shape)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P18760|dip:DIP-38073N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:nw/9u2+2nq9Ef43SapV43MeOtjE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P49615	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-6510052|ensembl:ENSMUSP00000030814	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:cdk5_mouse(display_long)|uniprotkb:Cdk5(gene name)|psi-mi:Cdk5(display_short)|uniprotkb:Cdkn5(gene name synonym)|uniprotkb:Crk6(gene name synonym)|uniprotkb:CR6 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000028969(gene)|ensembl:ENSMUST00000030814(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042220"(response to cocaine)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099533"(positive regulation of presynaptic cytosolic calcium concentration)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49615|reactome:R-MMU-180024|reactome:R-MMU-399956|reactome:R-MMU-6804756|refseq:NP_031694.1|dip:DIP-29353N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:mFzCd7zhLyXpxPDQwc1xXCraDQI10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P47754	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-299188|ensembl:ENSMUSP00000015877	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:caza2_mouse(display_long)|uniprotkb:Capza2(gene name)|psi-mi:Capza2(display_short)|uniprotkb:Cappa2(gene name synonym)|uniprotkb:CapZ alpha-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUST00000015877(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P47754|reactome:R-MMU-2132295|reactome:R-MMU-3371497|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-879415|reactome:R-MMU-983231|ensembl:ENSMUSG00000015733(gene)|refseq:NP_031630.1|dip:DIP-31382N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:9nxfEbrpHlDtTYwSvHAJvZLLweo10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q6ZQ38	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-597255|uniprotkb:Q6PFR0|uniprotkb:Q9CV45|ensembl:ENSMUSP00000020315	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:cand1_mouse(display_long)|uniprotkb:Cullin-associated and neddylation-dissociated protein 1(gene name synonym)|uniprotkb:p120 CAND1(gene name synonym)|uniprotkb:Cand1(gene name)|psi-mi:Cand1(display_short)|uniprotkb:D10Ertd516e(gene name synonym)|uniprotkb:Kiaa0829(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_082270.1|ensembl:ENSMUSG00000020114(gene)|ensembl:ENSMUST00000020315(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039852|mint:Q6ZQ38|reactome:R-MMU-6798695|reactome:R-MMU-8951664|reactome:R-MMU-917937	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:E6bJujLfT/V3C8Iyk0hUD1m4gT010090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q6PHZ2	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2308458|uniprotkb:Q3UF87|uniprotkb:Q3UQH9|uniprotkb:Q5DTK4|uniprotkb:Q8CAC5|uniprotkb:Q9CZE2|ensembl:ENSMUSP00000143504	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kcc2d_mouse(display_long)|uniprotkb:Camk2d(gene name)|psi-mi:Camk2d(display_short)|uniprotkb:Kiaa4163(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001020609.1|refseq:NP_076302.1|refseq:NP_001020610.1|refseq:NP_001280592.1|refseq:NP_001280593.1|dip:DIP-47638N|ensembl:ENSMUSG00000053819(gene)|ensembl:ENSMUST00000199300(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031432"(titin binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q6PHZ2|rcsb pdb:6BAB|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:z2mz73Kq9gwpKgo2Todn0IxQpSI10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P28652	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P11798	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:O88602	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-770326|ensembl:ENSMUSP00000019290	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ccg2_mouse(display_long)|uniprotkb:Neuronal voltage-gated calcium channel gamma-2 subunit(gene name synonym)|uniprotkb:Stargazin(gene name synonym)|uniprotkb:Cacng2(gene name)|psi-mi:Cacng2(display_short)|uniprotkb:Stg(gene name synonym)|uniprotkb:Transmembrane AMPAR regulatory protein gamma-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_031609.1|dip:DIP-32457N|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016247"(channel regulator activity)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0050877"(nervous system process)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060082"(eye blink reflex)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099590"(neurotransmitter receptor internalization)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904510"(positive regulation of protein localization to basolateral plasma membrane)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR005422(Voltage-dependent calcium channel, gamma-2 subunit)|interpro:IPR008368(Voltage-dependent calcium channel, gamma subunit)|rcsb pdb:3JXT|rcsb pdb:4X3H|rcsb pdb:5KBS|rcsb pdb:5KBT|rcsb pdb:5KBU|rcsb pdb:5WEO|reactome:R-MMU-112308|reactome:R-MMU-399719|reactome:R-MMU-5682910|ensembl:ENSMUSG00000019146(gene)|ensembl:ENSMUST00000019290(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006612"(protein targeting to membrane)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:horuxO013U9eKJYCTV7fS8OC0BY10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q6GQW0	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2308397|uniprotkb:Q6PCZ7|uniprotkb:Q8CAD2|uniprotkb:Q8CDA2|uniprotkb:Q9D3B9|ensembl:ENSMUSP00000100944	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:btbdb_mouse(display_long)|uniprotkb:Btbd11(gene name)|psi-mi:Btbd11(display_short)|uniprotkb:BTB/POZ domain-containing protein 11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001017525.1|refseq:NP_082985.2|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002110(Ankyrin)|interpro:IPR009072(Histone-fold)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR020683|interpro:IPR036770|ensembl:ENSMUSG00000020042(gene)|ensembl:ENSMUST00000105307(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046982"(protein heterodimerization activity)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:QyuqnS0wv/lYdgsX7P04pnGUqH010090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q68EF6	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2310845|ensembl:ENSMUSP00000158999	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:begin_mouse(display_long)|uniprotkb:Begain(gene name)|psi-mi:Begain(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:XP_011242432.1|refseq:NP_001156647.1|refseq:XP_006516107.1|ensembl:ENSMUSG00000040867(gene)|ensembl:ENSMUST00000238841(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098817"(evoked excitatory postsynaptic potential)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR033584|interpro:IPR043441	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:F3zprvxGqUithFEHDTFZJDTWiOA10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q91XV3	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-772877|ensembl:ENSMUSP00000053943	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:basp1_mouse(display_long)|uniprotkb:Neuronal axonal membrane protein NAP-22(gene name synonym)|uniprotkb:22 kDa neuronal tissue-enriched acidic protein(gene name synonym)|uniprotkb:Basp1(gene name)|psi-mi:Basp1(display_short)|uniprotkb:Nap22(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_081671.1|ensembl:ENSMUSG00000045763(gene)|ensembl:ENSMUST00000058845(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030426"(growth cone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|interpro:IPR008408(Brain acid soluble protein 1)|mint:Q91XV3|reactome:R-MMU-9035034	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:dwUwWfxMdUr+bki6HEHeaEibNOQ10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8BKX1	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P59999	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-445034|uniprotkb:O15509|uniprotkb:Q3UWV4|ensembl:ENSMUSP00000114839	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:arpc4_mouse(display_long)|uniprotkb:Arp2/3 complex 20 kDa subunit(gene name synonym)|uniprotkb:Arpc4(gene name)|psi-mi:Arpc4(display_short)|uniprotkb:Arc20(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001163956.1|refseq:NP_001163957.1|refseq:NP_080828.1|ensembl:ENSMUSG00000079426(gene)|ensembl:ENSMUST00000156898(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0051015"(actin filament binding)|interpro:IPR008384(ARP23 complex 20 kDa subunit)|interpro:IPR034666|mint:P59999|rcsb pdb:7AQK|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-5663213|reactome:R-MMU-8856828	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:Iqe60TWfO3QBVOY+fOqZd9JWfIE10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P61205	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-444797|uniprotkb:P16587|ensembl:ENSMUSP00000050689	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:arf3_mouse(display_long)|uniprotkb:Arf3(gene name)|psi-mi:Arf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_031504.1|refseq:XP_011243747.1|ensembl:ENSMUSG00000051853(gene)|ensembl:ENSMUST00000053183(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P61205|reactome:R-MMU-1660514|reactome:R-MMU-6807878|reactome:R-MMU-6811434	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:np09WjdbXRu9vgMbiXn9EA3ExqA10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9WV31	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-397779|ensembl:ENSMUSP00000023268|ensembl:ENSMUSP00000105636|uniprotkb:Q9ES15	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:arc_mouse(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001263613.1|ensembl:ENSMUSG00000022602(gene)|ensembl:ENSMUST00000023268(transcript)|ensembl:ENSMUST00000110009(transcript)|refseq:NP_061260.1|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|dip:DIP-31565N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:vZutgYl26hWTDm9UgMeY8dtgbg810090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8BIZ1	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-16724439|uniprotkb:E9Q644|uniprotkb:Q4KMR9|uniprotkb:Q8BJ47|uniprotkb:Q8BJ49	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ans1b_mouse(display_long)|uniprotkb:Amyloid-beta protein intracellular domain-associated protein 1(gene name synonym)|uniprotkb:E2A-PBX1-associated protein(gene name synonym)|uniprotkb:Anks1b(gene name)|psi-mi:Anks1b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	interpro:IPR041880|interpro:IPR041882|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900383"(regulation of synaptic plasticity by receptor localization to synapse)|mint:Q8BIZ1|refseq:NP_001170868.1|refseq:NP_001170869.1|refseq:NP_001333982.1|refseq:NP_001333983.1|refseq:NP_852063.1|interpro:IPR033636|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:xm2OG9kb/tmIo7e7c/qXBE4JeAY10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:P59672	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2310776|uniprotkb:Q6ZQG0|ensembl:ENSMUSP00000110491	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ans1a_mouse(display_long)|uniprotkb:Anks1a(gene name)|psi-mi:Anks1a(display_short)|uniprotkb:Anks1(gene name synonym)|uniprotkb:Kiaa0229(gene name synonym)|uniprotkb:Odin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001272970.1|refseq:NP_852078.1|ensembl:ENSMUSG00000024219(gene)|ensembl:ENSMUST00000114842(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0016322"(neuron remodeling)|go:"GO:0043005"(neuron projection)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1901187"(regulation of ephrin receptor signaling pathway)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033637|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|mint:P59672|rcsb pdb:5ZRY	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:nnkofMZa8AUPqZcbgGAYSHS4Lk810090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q9R1V6	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-770007|uniprotkb:Q5TLI8|uniprotkb:Q5TLI9|uniprotkb:Q5TLJ0|uniprotkb:Q5TLJ1|uniprotkb:Q5TLJ2|uniprotkb:Q5TLJ3|uniprotkb:Q5TLJ4|uniprotkb:Q5TLJ5|uniprotkb:Q5TLJ6|uniprotkb:Q5TLJ7|uniprotkb:Q5TLJ8|uniprotkb:Q5TLJ9|uniprotkb:Q5TLK0|uniprotkb:Q5TLK1|uniprotkb:Q5TLK2|uniprotkb:Q5TLK3|uniprotkb:Q5TLK4|uniprotkb:Q5TLK5|uniprotkb:Q5TLK6|uniprotkb:Q5TLK7|uniprotkb:Q5TLK8|uniprotkb:Q8BSF2|uniprotkb:Q9R1V5|ensembl:ENSMUSP00000086139	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ada22_mouse(display_long)|uniprotkb:Adam22(gene name)|psi-mi:Adam22(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001007221.1|refseq:NP_001007222.1|refseq:NP_001091695.1|refseq:NP_001297368.1|refseq:NP_001297369.1|refseq:XP_006503592.1|refseq:XP_006503593.1|refseq:XP_006503594.1|refseq:XP_006503596.1|refseq:XP_006503598.1|refseq:XP_006503600.1|refseq:XP_006503605.1|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR013111(EGF, extracellular)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:Q9R1V6|reactome:R-MMU-5682910|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|ensembl:ENSMUSG00000040537(gene)|ensembl:ENSMUST00000088761(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030424"(axon)|go:"GO:0042063"(gliogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:jOd0AHmc5bv3EK95Q84gaYLiKx010090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q5SSL4	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2310685|uniprotkb:Q3U5G0|uniprotkb:Q3UQJ6|uniprotkb:Q3UY38|uniprotkb:Q5SYJ5|uniprotkb:Q5SYJ7|uniprotkb:Q5SYJ8|uniprotkb:Q5SYJ9|uniprotkb:Q6PCY1|uniprotkb:Q6PDH3|ensembl:ENSMUSP00000072522	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:abr_mouse(display_long)|uniprotkb:Abr(gene name)|psi-mi:Abr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001333599.1|refseq:NP_001278115.1|refseq:NP_942597.1|refseq:NP_932135.1|refseq:NP_942598.1|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043197"(dendritic spine)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060313"(negative regulation of blood vessel remodeling)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000198(RhoGAP)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR035892|interpro:IPR035899|interpro:IPR037769|interpro:IPR037865|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|ensembl:ENSMUSG00000017631(gene)|ensembl:ENSMUST00000072740(transcript)|go:"GO:0002692"(negative regulation of cellular extravasation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:rkYDNM1hPvcrtB4OrgtHGMK0NTs10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q62108	uniprotkb:Q8K4G5	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-2307994|uniprotkb:Q80U86|uniprotkb:Q8BIR9|uniprotkb:Q8K4G3|uniprotkb:Q8K4G4	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:ablm1_mouse(display_long)|uniprotkb:Ablim1(gene name)|psi-mi:Ablim1(display_short)|uniprotkb:Ablim(gene name synonym)|uniprotkb:Kiaa0059(gene name synonym)|uniprotkb:Actin-binding LIM protein family member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16724752|imex:IM-26285-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001096647.1|refseq:NP_848803.3|interpro:IPR003128(Villin headpiece)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_001096648.1|refseq:NP_001277742.1|refseq:NP_001277744.1|interpro:IPR032402|interpro:IPR028448|mint:Q8K4G5|interpro:IPR036886|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060271"(cilium assembly)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig. 1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/04/12	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:UteUUoDaSxN+RrZNRUyx9jrzqHc10090	rigid:bghCsHtI6qr4ue6V2tzqdT4IfRE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q80TH2	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-7320461|uniprotkb:Q8K171|uniprotkb:E9QND6|uniprotkb:Q8CE41|uniprotkb:Q8BQ14|uniprotkb:Q9JI47|intact:MINT-138078|uniprotkb:Q99JU3|ensembl:ENSMUSP00000088813	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:erbin_mouse(display_long)|uniprotkb:Erbin(gene name)|psi-mi:Erbin(display_short)|uniprotkb:Densin-180-like protein(gene name synonym)|uniprotkb:Erbb2-interacting protein(gene name synonym)|uniprotkb:Erbb2ip(gene name synonym)|uniprotkb:Kiaa1225(gene name synonym)|uniprotkb:Lap2(gene name synonym)|uniprotkb:Protein LAP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000021709(gene)|ensembl:ENSMUST00000091269(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR032927|interpro:IPR036034|reactome:R-MMU-1227986|reactome:R-MMU-8863795|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9652282|refseq:NP_001005868.1|refseq:NP_001276402.1|refseq:NP_001276403.1|refseq:NP_001276404.1	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:8/YYmKxiql+Xa8+qsF+qTgYSU0M10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8C008	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-8317102|uniprotkb:Q8C060|intact:MINT-4113786|uniprotkb:A2AN93|ensembl:ENSMUSP00000080643	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dzan1_mouse(display_long)|uniprotkb:Dzank1(gene name)|psi-mi:Dzank1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_766447.2|ensembl:ENSMUSG00000037259(gene)|ensembl:ENSMUST00000081982(transcript)|go:"GO:0046872"(metal ion binding)|interpro:IPR025874|interpro:IPR026876|interpro:IPR036770|mint:Q8C008	go:"GO:0014069"(postsynaptic density)	-	comment:mint	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:ozGQu95/TVKGDwRgLlTCq+bl3PM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8CGM1	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-8014984|uniprotkb:B1ASB7|intact:MINT-1504097|uniprotkb:Q6PGN0|uniprotkb:B1ASB8|uniprotkb:Q3UNE2|uniprotkb:Q3TYC8|uniprotkb:Q3UN11|uniprotkb:B2FDE3|ensembl:ENSMUSP00000101636	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:agrb2_mouse(display_long)|uniprotkb:Adgrb2(gene name)|psi-mi:Adgrb2(display_short)|uniprotkb:Bai2(gene name synonym)|uniprotkb:Brain-specific angiogenesis inhibitor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001186625.1|refseq:NP_775094.2|refseq:NP_001277643.1|refseq:NP_001277644.1|ensembl:ENSMUSG00000028782(gene)|ensembl:ENSMUST00000106015(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0051965"(positive regulation of synapse assembly)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR008077(GPCR, family 2, brain-specific angiogenesis inhibitor)|interpro:IPR017981|interpro:IPR032471|interpro:IPR036383|interpro:IPR036445|interpro:IPR043838	go:"GO:0014069"(postsynaptic density)	-	function:Might be involved in angiogenesis inhibition|comment:mint|comment:homomint	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:8rlZowKB2ecMLVMojYSZDIwjx9410090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P98203	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-8399145|uniprotkb:Q924L3|uniprotkb:Q924L2|uniprotkb:Q8BQ36|uniprotkb:Q6PGJ6|uniprotkb:Q8C3U7|uniprotkb:Q924L4|uniprotkb:Q924L5|intact:MINT-4123053|uniprotkb:Q8BRF2|ensembl:ENSMUSP00000159426|ensembl:ENSMUSP00000159427	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:arvc_mouse(display_long)|uniprotkb:Arvcf(gene name)|psi-mi:Arvcf(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001258957.1|refseq:NP_001258960.1|refseq:NP_001258958.1|refseq:NP_258435.2|refseq:NP_001258959.1|refseq:NP_001258961.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0045296"(cadherin binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|interpro:IPR028444|mint:P98203|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000118669(gene)|ensembl:ENSMUST00000239534(transcript)|ensembl:ENSMUST00000239535(transcript)	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:Involved in protein-protein interactions at adherens junctions	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:7brlaZI4C07uNoqAPYZBkW2SWDg10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q811P8	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-6949116|ensembl:ENSMUSP00000133898|intact:MINT-268399|uniprotkb:B9EHJ8|uniprotkb:Q6A010	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:rhg32_mouse(display_long)|uniprotkb:RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling(gene name synonym)|uniprotkb:Rics(gene name synonym)|uniprotkb:p200RhoGAP(gene name synonym)|uniprotkb:p250GAP(gene name synonym)|uniprotkb:Arhgap32(gene name)|psi-mi:Arhgap32(display_short)|uniprotkb:Brain-specific Rho GTPase-activating protein(gene name synonym)|uniprotkb:GAB-associated Cdc42/Rac GTPase-activating protein(gene name synonym)|uniprotkb:GC-GAP(gene name synonym)|uniprotkb:Grit(gene name synonym)|uniprotkb:Kiaa0712(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 32(gene name synonym)|uniprotkb:Rho/Cdc42/Rac GTPase-activating protein RICS(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000041444(gene)|ensembl:ENSMUST00000174641(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001650"(fibrillar center)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005938"(cell cortex)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0043197"(dendritic spine)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036028|interpro:IPR036871|interpro:IPR042139|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-9035034|refseq:NP_796353.3|refseq:NP_001182561.1	go:"GO:0014069"(postsynaptic density)	-	comment:mint	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:4ZVZeciVms1xmC18riIhaDt9wMY10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P84084	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-7569461|uniprotkb:P26437|intact:UNK-5383724|uniprotkb:A2RTC5|ensembl:ENSMUSP00000020717|ensembl:ENSMUSP00000127281	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:arf5_mouse(display_long)|uniprotkb:Arf5(gene name)|psi-mi:Arf5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_031506.1|ensembl:ENSMUSG00000020440(gene)|ensembl:ENSMUST00000020717(transcript)|ensembl:ENSMUST00000169841(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|reactome:R-MMU-6807878|reactome:R-MMU-6811434	go:"GO:0014069"(postsynaptic density)	-	function:GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus|comment:mint|comment:homomint	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:da8exbGR3MGxZ6CPZqLvqJbyUYI10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8CFI0	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-8046183|uniprotkb:Q8BS42|uniprotkb:Q8BRT9|intact:MINT-5097552|uniprotkb:Q99PK2	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:ned4l_mouse(display_long)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:Nedd4l(gene name)|psi-mi:Nedd4l(display_short)|uniprotkb:Kiaa0439(gene name synonym)|uniprotkb:Nedd4b(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	dip:DIP-48843N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0009651"(response to salt stress)|go:"GO:0010038"(response to metal ion)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:1WR3|rcsb pdb:1WR4|rcsb pdb:1WR7|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-MMU-2173795|reactome:R-MMU-2672351|reactome:R-MMU-983168	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:rne2aA4b/xoATCErEBuu9uK3Zxk10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q61584	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q6ZPJ3	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-6999453|ensembl:ENSMUSP00000080791|intact:MINT-7034165|uniprotkb:Q60800|uniprotkb:A2A7X3|uniprotkb:Q7TPN2|uniprotkb:Q8BLE8|uniprotkb:Q6PCR9	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:ube2o_mouse(display_long)|uniprotkb:E2/E3 hybrid ubiquitin-protein ligase UBE2O(gene name synonym)|uniprotkb:Ube2o(gene name)|psi-mi:Ube2o(display_short)|uniprotkb:Kiaa1734(gene name synonym)|uniprotkb:Ubiquitin-protein ligase O(gene name synonym)|uniprotkb:Ubiquitin carrier protein O(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 of 230 kDa(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 O(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000020802(gene)|ensembl:ENSMUST00000082152(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|mint:Q6ZPJ3|reactome:R-MMU-983168|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_776116.2	go:"GO:0014069"(postsynaptic density)	-	comment:mint	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:7DrbsONnQCbVgpH24alvrdtoyJg10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P83510	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q3UTJ2	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-8345744|uniprotkb:Q80TS1|intact:MINT-1853612|uniprotkb:Q3USC6|uniprotkb:Q8BX47|uniprotkb:Q8CHU0|uniprotkb:Q8BLW9|intact:MINT-4116161|uniprotkb:Q8BJL6|uniprotkb:Q8BJU3	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:srbs2_mouse(display_long)|uniprotkb:Sorbs2(gene name)|psi-mi:Sorbs2(display_short)|uniprotkb:Arg/Abl-interacting protein 2(gene name synonym)|uniprotkb:Argbp2(gene name synonym)|uniprotkb:Kiaa0777(gene name synonym)|uniprotkb:Arg-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001297636.1|interpro:IPR003127(Sorbin-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR028506|interpro:IPR036028|mint:Q3UTJ2|refseq:XP_006509449.1|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR001452(Src homology-3)	go:"GO:0014069"(postsynaptic density)	-	comment:"fragmentation type: fragment"	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:2sKDQux/2IV7mW8l6LK36D3qlqw10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8VBX6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-8026435|uniprotkb:Q8VBV5|uniprotkb:Q6P7U4|uniprotkb:Q8VBY0|uniprotkb:B7ZNA1|uniprotkb:Q9Z1K3|uniprotkb:O08783|uniprotkb:Q8BKJ1|uniprotkb:Q8C0H8|intact:MINT-146667|uniprotkb:Q80ZY8|ensembl:ENSMUSP00000099894	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:mpdz_mouse(display_long)|uniprotkb:Mpdz(gene name)|psi-mi:Mpdz(display_short)|uniprotkb:Mupp1(gene name synonym)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001292213.1|refseq:NP_001292215.1|refseq:NP_034950.2|dip:DIP-41165N|ensembl:ENSMUSG00000028402(gene)|ensembl:ENSMUST00000102830(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042552"(myelination)|go:"GO:0043220"(Schmidt-Lanterman incisure)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:Q8VBX6|rcsb pdb:4XH7	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:PE6FMj7RyxofEiUpGMu97CF+TX810090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:A6X935	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-8346171|uniprotkb:Q8C7G9|uniprotkb:O54882|uniprotkb:Q8C7K5|uniprotkb:Q91W60|uniprotkb:Q505P8|intact:MINT-1858652|uniprotkb:Q9DBK8|ensembl:ENSMUSP00000112798	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:itih4_mouse(display_long)|uniprotkb:Itih4(gene name)|psi-mi:Itih4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_061216.2|refseq:NP_001152771.1|refseq:NP_001276561.1|refseq:NP_001276562.1|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006953"(acute-phase response)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0034097"(response to cytokine)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010600(Inter-alpha-trypsin inhibitor heavy chain, C-terminal)|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR036465|mint:A6X935|reactome:R-MMU-114608|ensembl:ENSMUSG00000021922(gene)|ensembl:ENSMUST00000120269(transcript)	go:"GO:0014069"(postsynaptic density)	-	comment:mint	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:7hMTiguIwMwVUDkReMMQWL8RM4k10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:F8VPU2	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16725343|ensembl:ENSMUSP00000026635|uniprotkb:C4IXU2	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:farp1_mouse(display_long)|uniprotkb:FERM, RhoGEF and pleckstrin domain-containing protein 1(gene name synonym)|uniprotkb:Farp1(gene name)|psi-mi:Farp1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000025555(gene)|ensembl:ENSMUST00000026635(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007416"(synapse assembly)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035899|interpro:IPR035963|interpro:IPR041788|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9035034|refseq:NP_598843.3|refseq:XP_006518977.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:FF1E2m+C2jrf4rDejtDV2rn93GA10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9WV92	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-911885|uniprotkb:Q69ZT8|ensembl:ENSMUSP00000079098|uniprotkb:Q9R102	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:e41l3_mouse(display_long)|uniprotkb:4.1B(gene name synonym)|uniprotkb:Differentially expressed in adenocarcinoma of the lung protein 1(gene name synonym)|uniprotkb:Epb41l3(gene name)|psi-mi:Epb41l3(display_short)|uniprotkb:Dal1(gene name synonym)|uniprotkb:Epb4.1l3(gene name synonym)|uniprotkb:Kiaa0987(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000024044(gene)|ensembl:ENSMUST00000080208(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043217"(myelin maintenance)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030691|interpro:IPR035963|mint:Q9WV92|reactome:R-MMU-6794361|refseq:NP_038841.1|refseq:XP_011244586.1|refseq:XP_011244591.1|refseq:XP_017172724.1|refseq:XP_017172725.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:51gkxiswTUqQbAUqjGoPthWD7jM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9Z2H5	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-774482|uniprotkb:Q3U3L1|uniprotkb:Q3UHP7|uniprotkb:Q80U34|uniprotkb:Q8K204	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:e41l1_mouse(display_long)|uniprotkb:Neuronal protein 4.1(gene name synonym)|uniprotkb:Epb41l1(gene name)|psi-mi:Epb41l1(display_short)|uniprotkb:Epb4(gene name synonym)|uniprotkb:Epb4.1l1(gene name synonym)|uniprotkb:Kiaa0338(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001278049.1|refseq:NP_001278051.1|refseq:NP_001278052.1|refseq:NP_001006665.1|refseq:NP_038538.1|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR019749|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019747|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR018979|interpro:IPR018980|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR007477(SAB)|interpro:IPR029071|interpro:IPR035963|mint:Q9Z2H5|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0097060"(synaptic membrane)|reactome:R-MMU-399719|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:Lu31NnWhI356njHUtKbBlaO6nWE10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9R0P5	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-1184008|ensembl:ENSMUSP00000099461	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dest_mouse(display_long)|uniprotkb:Dstn(gene name)|psi-mi:Dstn(display_short)|uniprotkb:Dsn(gene name synonym)|uniprotkb:Sid23(gene name synonym)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Sid 23(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_062745.1|ensembl:ENSMUSG00000015932(gene)|ensembl:ENSMUST00000103172(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR029006|interpro:IPR029924|mint:Q9R0P5	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:hqPae8VWEKvGPITqHtrSs78yI4M10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:O08553	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-446064|uniprotkb:Q6P5D0|ensembl:ENSMUSP00000022629	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dpyl2_mouse(display_long)|uniprotkb:Unc-33-like phosphoprotein 2(gene name synonym)|uniprotkb:Dpysl2(gene name)|psi-mi:Dpysl2(display_short)|uniprotkb:Crmp2(gene name synonym)|uniprotkb:Ulip2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_034085.2|ensembl:ENSMUSG00000022048(gene)|ensembl:ENSMUST00000022629(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043209"(myelin sheath)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098793"(presynapse)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030615|interpro:IPR032466|mint:O08553|rcsb pdb:5UQC|reactome:R-MMU-399956|reactome:R-MMU-437239	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:97yc8TNEPMcGtGNRLvl+KV+DYr010090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P39053	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-397785|ensembl:ENSMUSP00000122679|uniprotkb:A2AN50|uniprotkb:A2AN51|uniprotkb:A2AN54|uniprotkb:A2AN55|uniprotkb:Q3UNM1|uniprotkb:Q5DTN7|uniprotkb:Q61358|uniprotkb:Q61359|uniprotkb:Q61360|uniprotkb:Q6PDM5|uniprotkb:Q8JZZ4|uniprotkb:Q9CSY7|uniprotkb:Q9QXX1	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dyn1_mouse(display_long)|uniprotkb:Dnm1(gene name)|psi-mi:Dnm1(display_short)|uniprotkb:Dnm(gene name synonym)|uniprotkb:Kiaa4093(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_034195.2|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:P39053|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|ensembl:ENSMUSG00000026825(gene)|ensembl:ENSMUST00000139624(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904645"(response to amyloid-beta)|refseq:NP_001288666.1|refseq:XP_006497721.2|refseq:XP_006497722.2|refseq:XP_006497723.2|refseq:XP_006497724.2|refseq:XP_006497718.2|refseq:XP_017170817.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:wtPz3gwyxU6tAgh5091LQpt099I10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q80TZ3	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-773072|uniprotkb:Q6P2K9|uniprotkb:Q8C7L9|uniprotkb:B1B0B9|ensembl:ENSMUSP00000044251	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:auxi_mouse(display_long)|uniprotkb:DnaJ homolog subfamily C member 6(gene name synonym)|uniprotkb:Dnajc6(gene name)|psi-mi:Dnajc6(display_short)|uniprotkb:Kiaa0473(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001158055.1|refseq:NP_001158056.1|refseq:NP_001158057.1|refseq:NP_940804.1|refseq:XP_017175882.1|ensembl:ENSMUSG00000028528(gene)|ensembl:ENSMUST00000038207(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098793"(presynapse)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|interpro:IPR036869|mint:Q80TZ3|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-8856828	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:5GFmotNm8YcyPXpIr1cCVmXQ+Jw10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:B1AZP2	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-645637|uniprotkb:B1AZP3|uniprotkb:Q3KQQ8|uniprotkb:Q6PD44|uniprotkb:Q6XBF1|uniprotkb:Q80TN3|uniprotkb:Q8R3U9|uniprotkb:B7ZNS1|ensembl:ENSMUSP00000126980	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dlgp4_mouse(display_long)|uniprotkb:Kiaa0964(gene name synonym)|uniprotkb:Sapap4(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 4(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 4(gene name synonym)|uniprotkb:Dlgap4(gene name)|psi-mi:Dlgap4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001035952.1|refseq:NP_666240.4|refseq:NP_001264115.1|refseq:NP_001035953.1|refseq:NP_001264116.1|refseq:XP_006499403.1|ensembl:ENSMUSG00000061689(gene)|ensembl:ENSMUST00000169464(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023052"(signaling)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030527|mint:B1AZP2|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:Ksjp5jiwjvzSymdyt1kSs8I+1pE10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q6PFD5	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2308733|uniprotkb:Q6PDX0|uniprotkb:Q6XBF2|ensembl:ENSMUSP00000039724|ensembl:ENSMUSP00000101700	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dlgp3_mouse(display_long)|uniprotkb:Dlgap3(gene name)|psi-mi:Dlgap3(display_short)|uniprotkb:Dap3(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 3(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:XP_011238839.1|refseq:NP_941020.1|refseq:NP_001289010.1|ensembl:ENSMUSG00000042388(gene)|ensembl:ENSMUST00000046659(transcript)|ensembl:ENSMUST00000106094(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023052"(signaling)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030526|mint:Q6PFD5|rcsb pdb:5IZU|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:mkXYwYR5Snou4RA8d71UDC7G59I10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8BJ42	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2308675|uniprotkb:Q6XBF3|ensembl:ENSMUSP00000039647|ensembl:ENSMUSP00000119613	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dlgp2_mouse(display_long)|uniprotkb:Dlgap2(gene name)|psi-mi:Dlgap2(display_short)|uniprotkb:Dap2(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 2(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001139437.1|refseq:NP_766498.2|refseq:XP_017168275.1|ensembl:ENSMUSG00000047495(gene)|ensembl:ENSMUST00000043279(transcript)|ensembl:ENSMUST00000133298(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0043197"(dendritic spine)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030525|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:9V3GlRM3AupA70mmFtZ4biXuC9E10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q62108	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P70175	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-396969|ensembl:ENSMUSP00000085299	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dlg3_mouse(display_long)|uniprotkb:Dlg3(gene name)|psi-mi:Dlg3(display_short)|uniprotkb:Dlgh3(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_058027.1|refseq:NP_001171249.1|ensembl:ENSMUSG00000000881(gene)|ensembl:ENSMUST00000087984(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|mint:P70175|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-6794361|reactome:R-MMU-8849932|dip:DIP-31585N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:9dR9P876v8QcvPinxtaWzDgpHwE10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q91XM9	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-400138|uniprotkb:Q8BXK7|uniprotkb:Q8BYG5|ensembl:ENSMUSP00000102814|uniprotkb:F8VQM7	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dlg2_mouse(display_long)|uniprotkb:Dlg2(gene name)|psi-mi:Dlg2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000052572(gene)|ensembl:ENSMUST00000107196(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035759|interpro:IPR036028|interpro:IPR036034|mint:Q91XM9|rcsb pdb:2WL7|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6794361|refseq:NP_001229976.1|refseq:NP_035937.2|dip:DIP-31569N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:37/IFbjDNxh87dnN2gglIgDGyIU10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q811D0	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-514290|uniprotkb:Q62402|uniprotkb:Q6PGB5|uniprotkb:Q8CGN7|ensembl:ENSMUSP00000097581|ensembl:ENSMUSP00000110859	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dlg1_mouse(display_long)|uniprotkb:Synapse-associated protein 97(gene name synonym)|uniprotkb:Embryo-dlg/synapse-associated protein 97(gene name synonym)|uniprotkb:Dlg1(gene name)|psi-mi:Dlg1(display_short)|uniprotkb:Dlgh1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_031888.2|refseq:NP_001239362.1|refseq:NP_001239364.1|refseq:XP_006521831.1|refseq:NP_001239363.1|dip:DIP-31591N|ensembl:ENSMUSG00000022770(gene)|ensembl:ENSMUST00000100001(transcript)|ensembl:ENSMUST00000115205(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034629"|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043219"(lateral loop)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060022"(hard palate development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1902473"(regulation of protein localization to synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903286"(regulation of potassium ion import)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903760"(regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:1903764"(regulation of potassium ion export across plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR015143(L27-1)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q811D0|rcsb pdb:4OAJ|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-8849932	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:b8LjYbiuR2K6/jxhwU1hxBJKX6410090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:O08808	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-1026445|ensembl:ENSMUSP00000111297	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:diap1_mouse(display_long)|uniprotkb:Diaphanous-related formin-1(gene name synonym)|uniprotkb:p140mDIA(gene name synonym)|uniprotkb:Diaph1(gene name)|psi-mi:Diaph1(display_short)|uniprotkb:Diap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_031884.1|ensembl:ENSMUSG00000024456(gene)|ensembl:ENSMUST00000115634(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005903"(brush border)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007420"(brain development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O08808|rcsb pdb:1Z2C|rcsb pdb:2BAP|rcsb pdb:2BNX|rcsb pdb:2F31|rcsb pdb:2V8F|rcsb pdb:3EG5|rcsb pdb:3O4X|rcsb pdb:3OBV|rcsb pdb:4UWX|reactome:R-MMU-5663220|reactome:R-MMU-6785631|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013405|reactome:R-MMU-9035034|rcsb pdb:1V9D|dip:DIP-29028N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:cSWfzfilw9WnzAOYZE3i+0x9G5c10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q80TS7	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16725318|ensembl:ENSMUSP00000074895|uniprotkb:Q3TPT2|uniprotkb:Q3TY46	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dend_mouse(display_long)|uniprotkb:Ddn(gene name)|psi-mi:Ddn(display_short)|uniprotkb:Gm748(gene name synonym)|uniprotkb:Kiaa0749(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000059213(gene)|ensembl:ENSMUST00000075444(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0042995"(cell projection)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR026500|rcsb pdb:6J69|rcsb pdb:6JJZ|rcsb pdb:6JK0|rcsb pdb:6JK1|rcsb pdb:6KKG|rcsb pdb:7BQG|refseq:NP_001013763.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:XTb8iMdZY6ldSiQVXuwx2ofQeVs10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q3UHC7	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-6306507|ensembl:ENSMUSP00000088532|uniprotkb:A2AUW9|uniprotkb:A2AUX2|uniprotkb:B7ZD28|uniprotkb:Q3TPD5|uniprotkb:Q3UH44|uniprotkb:Q6JTV1|uniprotkb:Q80T97|uniprotkb:A5X2X2|uniprotkb:Q6Y636	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dab2p_mouse(display_long)|uniprotkb:ASK-interacting protein 1(gene name synonym)|uniprotkb:DOC-2/DAB-2 interactive protein(gene name synonym)|uniprotkb:Dab2ip(gene name)|psi-mi:Dab2ip(display_short)|uniprotkb:Kiaa1743(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000026883(gene)|ensembl:ENSMUST00000091010(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007049"(cell cycle)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021814"(cell motility involved in cerebral cortex radial glia guided migration)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035148"(tube formation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043553"(negative regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044301"(climbing fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1903363"(negative regulation of cellular protein catabolic process)|go:"GO:1990032"(parallel fiber)|go:"GO:1990597"(AIP1-IRE1 complex)|go:"GO:2001224"(positive regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR030403|interpro:IPR035892|interpro:IPR039360|reactome:R-MMU-5658442|interpro:IPR001849(Pleckstrin-like)|refseq:NP_001277568.1|refseq:NP_001277569.1|refseq:NP_001277570.1|refseq:NP_001001602.2|refseq:NP_001107596.1|refseq:NP_001107597.1|refseq:XP_006498370.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:2TdjnHyR0jQG+iT5S5+JaK8hhfY10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:O08967	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16725278|ensembl:ENSMUSP00000112157|uniprotkb:Q8CI93	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:cyh3_mouse(display_long)|uniprotkb:ARF nucleotide-binding site opener 3(gene name synonym)|uniprotkb:General receptor of phosphoinositides 1(gene name synonym)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 3(gene name synonym)|uniprotkb:SEC7 homolog C(gene name synonym)|uniprotkb:Cyth3(gene name)|psi-mi:Cyth3(display_short)|uniprotkb:Grp1(gene name synonym)|uniprotkb:Pscd3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000018001(gene)|ensembl:ENSMUST00000116456(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0090162"(establishment of epithelial cell polarity)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|rcsb pdb:1FGY|rcsb pdb:1FGZ|rcsb pdb:1FHW|rcsb pdb:1FHX|rcsb pdb:1U2B|rcsb pdb:2R09|rcsb pdb:2R0D|rcsb pdb:6BBP|rcsb pdb:6BBQ|reactome:R-MMU-6811438|refseq:NP_035312.3	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:SUSlHPxCGtFJpZM5a3R/pIpOFXU10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q80TQ2	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-943859|uniprotkb:Q80VB3|uniprotkb:Q8BXZ3|uniprotkb:Q8BYL9|uniprotkb:Q8CGB0|ensembl:ENSMUSP00000105254|ensembl:ENSMUSP00000147426|ensembl:ENSMUSP00000148037	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:cyld_mouse(display_long)|uniprotkb:Cyld(gene name)|psi-mi:Cyld(display_short)|uniprotkb:Cyld1(gene name synonym)|uniprotkb:Kiaa0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001121642.1|refseq:NP_001121643.1|refseq:NP_775545.1|refseq:XP_006531477.1|refseq:XP_006531478.1|refseq:XP_006531479.1|refseq:XP_006531480.1|refseq:XP_006531481.1|refseq:XP_011246825.1|refseq:XP_011246826.1|refseq:XP_011246827.1|refseq:XP_017168478.1|dip:DIP-35656N|ensembl:ENSMUSG00000036712(gene)|ensembl:ENSMUST00000109626(transcript)|ensembl:ENSMUST00000209559(transcript)|ensembl:ENSMUST00000211554(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689880|reactome:R-MMU-936440	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:U1ditS+hdqob77g9p8v9kSyOKsE10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q5SQX6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q7TMB8	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:O35927	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-774108|uniprotkb:B2RR80	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:ctnd2_mouse(display_long)|uniprotkb:Neural plakophilin-related ARM-repeat protein(gene name synonym)|uniprotkb:Neurojungin(gene name synonym)|uniprotkb:Ctnnd2(gene name)|psi-mi:Ctnnd2(display_short)|uniprotkb:Catnd2(gene name synonym)|uniprotkb:Nprap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0045296"(cadherin binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR028435|refseq:NP_032755.2|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|mint:O35927	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:/YXEXiU6UKZhK6McB762K0GKcN010090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P30999	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-529924|uniprotkb:Q3TSU9|uniprotkb:Q80XQ4|uniprotkb:Q8CHF8|ensembl:ENSMUSP00000064518|ensembl:ENSMUSP00000107320|ensembl:ENSMUSP00000141166	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:ctnd1_mouse(display_long)|uniprotkb:Kiaa0384(gene name synonym)|uniprotkb:p120 catenin(gene name synonym)|uniprotkb:Cadherin-associated Src substrate(gene name synonym)|uniprotkb:"p120(cas)"(gene name synonym)|uniprotkb:Ctnnd1(gene name)|psi-mi:Ctnnd1(display_short)|uniprotkb:Catns(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001078917.1|refseq:NP_001078918.1|refseq:NP_001078919.1|refseq:NP_001078922.1|refseq:NP_031641.2|refseq:XP_006498698.1|refseq:XP_017170690.1|refseq:XP_017170697.1|dip:DIP-31972N|ensembl:ENSMUSG00000034101(gene)|ensembl:ENSMUSG00000101645(gene)|ensembl:ENSMUST00000067232(transcript)|ensembl:ENSMUST00000111691(transcript)|ensembl:ENSMUST00000189772(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001822"(kidney development)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016600"(flotillin complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0043197"(dendritic spine)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060690"(epithelial cell differentiation involved in salivary gland development)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|interpro:IPR028439|mint:P30999|reactome:R-MMU-418990|reactome:R-MMU-5218920	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:CvcAbgejB5iLlsSAxt47G/6W3P410090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q02248	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:O54991	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-774794|uniprotkb:A2A4K6|ensembl:ENSMUSP00000099398	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:cntp1_mouse(display_long)|uniprotkb:Neurexin-4(gene name synonym)|uniprotkb:Neurexin IV(gene name synonym)|uniprotkb:Paranodin(gene name synonym)|uniprotkb:NCP1(gene name synonym)|uniprotkb:MHDNIV(gene name synonym)|uniprotkb:Cntnap1(gene name)|psi-mi:Cntnap1(display_short)|uniprotkb:Nrxn4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_058062.2|ensembl:ENSMUSG00000017167(gene)|ensembl:ENSMUST00000103109(transcript)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0005886"(plasma membrane)|go:"GO:0005918"(septate junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030424"(axon)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0033010"(paranodal junction)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR028872|interpro:IPR036056|mint:O54991	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:BTW+FjgSUq00WpWGDC6PpQcIowE10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q80YA9	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-771429|uniprotkb:Q80TP2|ensembl:ENSMUSP00000026750	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:cnkr2_mouse(display_long)|uniprotkb:Cnksr2(gene name)|psi-mi:Cnksr2(display_short)|uniprotkb:Kiaa0902(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_808419.1|refseq:NP_001297648.1|ensembl:ENSMUSG00000025658(gene)|ensembl:ENSMUST00000026750(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-MMU-5674135	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:bG3fvfM0wtqno1U+KQTLvhm6btA10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P49025	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-397301|intact:EBI-487846|uniprotkb:O88528|uniprotkb:O88937|uniprotkb:O88938|uniprotkb:Q3UM99|uniprotkb:Q8CIJ1	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:ctro_mouse(display_long)|uniprotkb:Cit(gene name)|psi-mi:Cit(display_short)|uniprotkb:Rho-interacting, serine/threonine-protein kinase 21(gene name synonym)|uniprotkb:Crik(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR017405(Citron Rho-interacting kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|refseq:XP_006530214.1|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001726"(ruffle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR037708|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005856"(cytoskeleton)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048699"(generation of neurons)|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-5625900	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:8kykadVIiyk12GjGCZNn0bQ13C010090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P49615	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-6510052|ensembl:ENSMUSP00000030814	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:cdk5_mouse(display_long)|uniprotkb:Cdk5(gene name)|psi-mi:Cdk5(display_short)|uniprotkb:Cdkn5(gene name synonym)|uniprotkb:Crk6(gene name synonym)|uniprotkb:CR6 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000028969(gene)|ensembl:ENSMUST00000030814(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042220"(response to cocaine)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099533"(positive regulation of presynaptic cytosolic calcium concentration)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49615|reactome:R-MMU-180024|reactome:R-MMU-399956|reactome:R-MMU-6804756|refseq:NP_031694.1|dip:DIP-29353N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:mFzCd7zhLyXpxPDQwc1xXCraDQI10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q6P9K8	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-771526|uniprotkb:Q6ZPU2|uniprotkb:Q8BWU2|uniprotkb:Q8BX99|uniprotkb:Q9CXH0|ensembl:ENSMUSP00000024958	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:cski1_mouse(display_long)|uniprotkb:CASK-interacting protein 1(gene name synonym)|uniprotkb:Caskin1(gene name)|psi-mi:Caskin1(display_short)|uniprotkb:Kiaa1306(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_082213.2|refseq:XP_006524378.1|ensembl:ENSMUSG00000033597(gene)|ensembl:ENSMUST00000024958(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001452(Src homology-3)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR027013|interpro:IPR032117|interpro:IPR032232|interpro:IPR035495|interpro:IPR035497|interpro:IPR035498|interpro:IPR036028|interpro:IPR036770|mint:Q6P9K8	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:zLkBAG7MLTXtMQ0HlY2ox2AumUE10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P47754	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-299188|ensembl:ENSMUSP00000015877	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:caza2_mouse(display_long)|uniprotkb:Capza2(gene name)|psi-mi:Capza2(display_short)|uniprotkb:Cappa2(gene name synonym)|uniprotkb:CapZ alpha-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUST00000015877(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P47754|reactome:R-MMU-2132295|reactome:R-MMU-3371497|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-879415|reactome:R-MMU-983231|ensembl:ENSMUSG00000015733(gene)|refseq:NP_031630.1|dip:DIP-31382N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:9nxfEbrpHlDtTYwSvHAJvZLLweo10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q923T9	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-771638|uniprotkb:Q3U3H3|uniprotkb:Q8VED3|ensembl:ENSMUSP00000071720	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kcc2g_mouse(display_long)|uniprotkb:Camk2g(gene name)|psi-mi:Camk2g(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001034227.1|refseq:NP_001034228.1|refseq:NP_848712.2|ensembl:ENSMUSG00000021820(gene)|ensembl:ENSMUST00000071816(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q923T9|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:pbJqcEUQJQRnAwcKozmS72n9s1w10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q6PHZ2	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2308458|uniprotkb:Q3UF87|uniprotkb:Q3UQH9|uniprotkb:Q5DTK4|uniprotkb:Q8CAC5|uniprotkb:Q9CZE2|ensembl:ENSMUSP00000143504	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kcc2d_mouse(display_long)|uniprotkb:Camk2d(gene name)|psi-mi:Camk2d(display_short)|uniprotkb:Kiaa4163(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001020609.1|refseq:NP_076302.1|refseq:NP_001020610.1|refseq:NP_001280592.1|refseq:NP_001280593.1|dip:DIP-47638N|ensembl:ENSMUSG00000053819(gene)|ensembl:ENSMUST00000199300(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031432"(titin binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q6PHZ2|rcsb pdb:6BAB|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:z2mz73Kq9gwpKgo2Todn0IxQpSI10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P28652	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P11798	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q6GQW0	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2308397|uniprotkb:Q6PCZ7|uniprotkb:Q8CAD2|uniprotkb:Q8CDA2|uniprotkb:Q9D3B9|ensembl:ENSMUSP00000100944	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:btbdb_mouse(display_long)|uniprotkb:Btbd11(gene name)|psi-mi:Btbd11(display_short)|uniprotkb:BTB/POZ domain-containing protein 11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001017525.1|refseq:NP_082985.2|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002110(Ankyrin)|interpro:IPR009072(Histone-fold)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR020683|interpro:IPR036770|ensembl:ENSMUSG00000020042(gene)|ensembl:ENSMUST00000105307(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046982"(protein heterodimerization activity)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:QyuqnS0wv/lYdgsX7P04pnGUqH010090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q68EF6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2310845|ensembl:ENSMUSP00000158999	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:begin_mouse(display_long)|uniprotkb:Begain(gene name)|psi-mi:Begain(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:XP_011242432.1|refseq:NP_001156647.1|refseq:XP_006516107.1|ensembl:ENSMUSG00000040867(gene)|ensembl:ENSMUST00000238841(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098817"(evoked excitatory postsynaptic potential)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR033584|interpro:IPR043441	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:F3zprvxGqUithFEHDTFZJDTWiOA10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8BKX1	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q80ZF8	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16724676|ensembl:ENSMUSP00000035612|ensembl:ENSMUSP00000116231|ensembl:ENSMUSP00000119804|uniprotkb:G3XA05	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:agrb3_mouse(display_long)|uniprotkb:Brain-specific angiogenesis inhibitor 3(gene name synonym)|uniprotkb:Adgrb3(gene name)|psi-mi:Adgrb3(display_short)|uniprotkb:Bai3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000033569(gene)|ensembl:ENSMUST00000041838(transcript)|ensembl:ENSMUST00000135518(transcript)|ensembl:ENSMUST00000151309(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0043083"(synaptic cleft)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061743"(motor learning)|go:"GO:0098794"(postsynapse)|go:"GO:0099558"(maintenance of synapse structure)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR008077(GPCR, family 2, brain-specific angiogenesis inhibitor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR032471|interpro:IPR036383|interpro:IPR036445|interpro:IPR043838|mint:Q80ZF8|refseq:NP_783573.4	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:gSLNnlXd3ua1ax9MiKbUQTHz/yQ10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P59281	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-772284|uniprotkb:Q69ZD4|uniprotkb:Q6P9R6|ensembl:ENSMUSP00000036697	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:rhg39_mouse(display_long)|uniprotkb:Arhgap39(gene name)|psi-mi:Arhgap39(display_short)|uniprotkb:D15Wsu169e(gene name synonym)|uniprotkb:Kiaa1688(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001161760.1|refseq:NP_940812.2|ensembl:ENSMUSG00000033697(gene)|ensembl:ENSMUST00000036176(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007165"(signal transduction)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036020|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9035034	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:Bm7bwXl6puNRxWYdWzAQynmHJ/E10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P61205	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-444797|uniprotkb:P16587|ensembl:ENSMUSP00000050689	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:arf3_mouse(display_long)|uniprotkb:Arf3(gene name)|psi-mi:Arf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_031504.1|refseq:XP_011243747.1|ensembl:ENSMUSG00000051853(gene)|ensembl:ENSMUST00000053183(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P61205|reactome:R-MMU-1660514|reactome:R-MMU-6807878|reactome:R-MMU-6811434	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:np09WjdbXRu9vgMbiXn9EA3ExqA10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9WV31	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-397779|ensembl:ENSMUSP00000023268|ensembl:ENSMUSP00000105636|uniprotkb:Q9ES15	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:arc_mouse(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001263613.1|ensembl:ENSMUSG00000022602(gene)|ensembl:ENSMUST00000023268(transcript)|ensembl:ENSMUST00000110009(transcript)|refseq:NP_061260.1|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|dip:DIP-31565N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:vZutgYl26hWTDm9UgMeY8dtgbg810090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q3UHD9	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-771911|uniprotkb:Q5DU45|ensembl:ENSMUSP00000043466	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:agap2_mouse(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Kiaa0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001028435.1|refseq:NP_001287943.1|ensembl:ENSMUSG00000025422(gene)|ensembl:ENSMUST00000039259(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|go:"GO:0005768"(endosome)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:yq2lQtfk+FPqgT++CxAx2CS69nE10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9R1V6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-770007|uniprotkb:Q5TLI8|uniprotkb:Q5TLI9|uniprotkb:Q5TLJ0|uniprotkb:Q5TLJ1|uniprotkb:Q5TLJ2|uniprotkb:Q5TLJ3|uniprotkb:Q5TLJ4|uniprotkb:Q5TLJ5|uniprotkb:Q5TLJ6|uniprotkb:Q5TLJ7|uniprotkb:Q5TLJ8|uniprotkb:Q5TLJ9|uniprotkb:Q5TLK0|uniprotkb:Q5TLK1|uniprotkb:Q5TLK2|uniprotkb:Q5TLK3|uniprotkb:Q5TLK4|uniprotkb:Q5TLK5|uniprotkb:Q5TLK6|uniprotkb:Q5TLK7|uniprotkb:Q5TLK8|uniprotkb:Q8BSF2|uniprotkb:Q9R1V5|ensembl:ENSMUSP00000086139	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:ada22_mouse(display_long)|uniprotkb:Adam22(gene name)|psi-mi:Adam22(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001007221.1|refseq:NP_001007222.1|refseq:NP_001091695.1|refseq:NP_001297368.1|refseq:NP_001297369.1|refseq:XP_006503592.1|refseq:XP_006503593.1|refseq:XP_006503594.1|refseq:XP_006503596.1|refseq:XP_006503598.1|refseq:XP_006503600.1|refseq:XP_006503605.1|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR013111(EGF, extracellular)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:Q9R1V6|reactome:R-MMU-5682910|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|ensembl:ENSMUSG00000040537(gene)|ensembl:ENSMUST00000088761(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030424"(axon)|go:"GO:0042063"(gliogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:jOd0AHmc5bv3EK95Q84gaYLiKx010090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8K4G5	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2307994|uniprotkb:Q80U86|uniprotkb:Q8BIR9|uniprotkb:Q8K4G3|uniprotkb:Q8K4G4	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:ablm1_mouse(display_long)|uniprotkb:Ablim1(gene name)|psi-mi:Ablim1(display_short)|uniprotkb:Ablim(gene name synonym)|uniprotkb:Kiaa0059(gene name synonym)|uniprotkb:Actin-binding LIM protein family member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001096647.1|refseq:NP_848803.3|interpro:IPR003128(Villin headpiece)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_001096648.1|refseq:NP_001277742.1|refseq:NP_001277744.1|interpro:IPR032402|interpro:IPR028448|mint:Q8K4G5|interpro:IPR036886|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060271"(cilium assembly)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:UteUUoDaSxN+RrZNRUyx9jrzqHc10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P28740	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-776122|uniprotkb:O54744|uniprotkb:Q91W03|ensembl:ENSMUSP00000022204	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kif2a_mouse(display_long)|uniprotkb:Kif2a(gene name)|psi-mi:Kif2a(display_short)|uniprotkb:Kif2(gene name synonym)|uniprotkb:Kns2(gene name synonym)|uniprotkb:Kinesin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001139251.1|refseq:XP_006517602.1|ensembl:ENSMUSG00000021693(gene)|ensembl:ENSMUST00000022204(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0051301"(cell division)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097228"(sperm principal piece)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P28740|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-6811434|reactome:R-MMU-68877|reactome:R-MMU-9648025|reactome:R-MMU-983189	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:xPWg0rzeKQooA3AM2Ics+e/QnRM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:O88809	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16724620|ensembl:ENSMUSP00000033642|ensembl:ENSMUSP00000084570|uniprotkb:Q6E5A4	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dcx_mouse(display_long)|uniprotkb:Doublin(gene name synonym)|uniprotkb:Lissencephalin-X(gene name synonym)|uniprotkb:Dcx(gene name)|psi-mi:Dcx(display_short)|uniprotkb:Dcn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000031285(gene)|ensembl:ENSMUST00000033642(transcript)|ensembl:ENSMUST00000087313(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0035082"(axoneme assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060041"(retina development in camera-type eye)|interpro:IPR003533(Doublecortin)|interpro:IPR017302(Neuronal migration protein doublecortin)|interpro:IPR036572|interpro:IPR040163|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|refseq:NP_001103692.1|refseq:NP_001103693.1|refseq:NP_001103694.1|refseq:NP_034155.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:bZVdhkO518ZmQJpBRfIqaTPon1Y10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9QXS6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-445208|uniprotkb:A2CG16|uniprotkb:Q3V234|uniprotkb:Q922X1|uniprotkb:Q9QXS5|ensembl:ENSMUSP00000021950	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dreb_mouse(display_long)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:Dbn1(gene name)|psi-mi:Dbn1(display_short)|uniprotkb:Drba(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001170842.1|refseq:NP_001170843.1|refseq:NP_062787.2|ensembl:ENSMUSG00000034675(gene)|ensembl:ENSMUST00000021950(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0005856"(cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048699"(generation of neurons)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0098828"(modulation of inhibitory postsynaptic potential)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:1904113"(negative regulation of muscle filament sliding)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q9QXS6|reactome:R-MMU-9013405|reactome:R-MMU-9013407|reactome:R-MMU-9013418|reactome:R-MMU-9013422	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:ArZUGZNIUfSwoIketPcPCXlSM8410090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:O70589	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-771402|uniprotkb:A2ADP8|uniprotkb:A2ADP9|uniprotkb:A2ADQ4|uniprotkb:O70588|uniprotkb:Q3UW92	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:cskp_mouse(display_long)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Cask(gene name)|psi-mi:Cask(display_short)|uniprotkb:Lin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001271432.1|refseq:NP_001271433.1|refseq:NP_001271434.1|refseq:NP_033936.2|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR011009(Protein kinase-like)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O70589|go:"GO:0060170"(ciliary membrane)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097440"(apical dendrite)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098846"(podocyte foot)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|rcsb pdb:1Y74|rcsb pdb:6Y9O|reactome:R-MMU-212676|reactome:R-MMU-6794361|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:3co6JdI4q/n5C8zGb5JYFL2t7pc10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9CQR6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-4286534|uniprotkb:A2ASL7|ensembl:ENSMUSP00000028087	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:ppp6_mouse(display_long)|uniprotkb:Ppp6c(gene name)|psi-mi:Ppp6c(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_077171.1|ensembl:ENSMUSG00000026753(gene)|ensembl:ENSMUST00000028087(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:Q9CQR6|reactome:R-MMU-171319|reactome:R-MMU-204005|go:"GO:0006470"(protein dephosphorylation)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:R0jsZoqJLoRaSNMNCLRkQ40CC+o10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P62137	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-357187|ensembl:ENSMUSP00000039109|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:Q3U7G7|uniprotkb:Q9Z1G2	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:pp1a_mouse(display_long)|uniprotkb:Ppp1ca(gene name)|psi-mi:Ppp1ca(display_short)|uniprotkb:Ppp1a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62137|rcsb pdb:5ZQV|rcsb pdb:5ZT0|reactome:R-MMU-180024|ensembl:ENSMUSG00000040385(gene)|ensembl:ENSMUST00000046094(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|refseq:NP_114074.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:kr38FkfqhN5ex5rxh4ZJbSdd8IM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:O88335	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-295404|ensembl:ENSMUSP00000046793|ensembl:ENSMUSP00000150540	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kcnj1_mouse(display_long)|uniprotkb:Kcnj1(gene name)|psi-mi:Kcnj1(display_short)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 1(gene name synonym)|uniprotkb:ATP-regulated potassium channel ROM-K(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir1.1"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_062633.1|ensembl:ENSMUSG00000041248(gene)|ensembl:ENSMUST00000047334(transcript)|ensembl:ENSMUST00000213393(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010467"(gene expression)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030955"(potassium ion binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042277"(peptide binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0072359"(circulatory system development)|go:"GO:1900128"(regulation of G-protein activated inward rectifier potassium channel activity)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR003268(Potassium channel, inwardly rectifying, Kir1.1)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|reactome:R-MMU-1296067	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:ctGjxRRWBKD0M5ESJAJfkntznMo10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q99JP6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-6272061|ensembl:ENSMUSP00000117033|uniprotkb:D3Z6N9|uniprotkb:Q9Z215	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:home3_mouse(display_long)|uniprotkb:Homer3(gene name)|psi-mi:Homer3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000003573(gene)|ensembl:ENSMUST00000140212(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q99JP6|reactome:R-MMU-6794361|refseq:NP_001139625.1|refseq:NP_036114.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:7IOPI8VTi6aKK/I0tl4AiUUIXIU10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8BMA3	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16724595|ensembl:ENSMUSP00000015346|uniprotkb:Q3UDS2|uniprotkb:Q8K2K0	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:cnkr3_mouse(display_long)|uniprotkb:CNK homolog protein 3(gene name synonym)|uniprotkb:CNKSR family member 3(gene name synonym)|uniprotkb:Maguin-like protein(gene name synonym)|uniprotkb:Cnksr3(gene name)|psi-mi:Cnksr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000015202(gene)|ensembl:ENSMUST00000015346(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|refseq:NP_766134.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:VU017cJ6L0oSQSKNSH5wShA80Lg10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P70398	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2214043|uniprotkb:E9QLY0|uniprotkb:Q62497	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:usp9x_mouse(display_long)|uniprotkb:Ubiquitin thioesterase FAF-X(gene name synonym)|uniprotkb:Usp9x(gene name)|psi-mi:Usp9x(display_short)|uniprotkb:Fafl(gene name synonym)|uniprotkb:Fam(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-X(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-X(gene name synonym)|uniprotkb:Fat facets protein-related, X-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, X chromosome(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase FAM(gene name synonym)|uniprotkb:Fat facets homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	interpro:IPR016024(Armadillo-type fold)|interpro:IPR028889|refseq:NP_033507.2|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:P70398|interpro:IPR038765|interpro:IPR021905|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021698"(cerebellar cortex structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0030426"(growth cone)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045177"(apical part of cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|reactome:R-MMU-2173795|reactome:R-MMU-5689880|reactome:R-MMU-8866652|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-9033241	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:QXx5gkd+PxoNgIj2b2dLjpCuNr410090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P97820	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-644181	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:m4k4_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase kinase 4(gene name synonym)|uniprotkb:HPK/GCK-like kinase HGK(gene name synonym)|uniprotkb:Nck-interacting kinase(gene name synonym)|uniprotkb:Map4k4(gene name)|psi-mi:Map4k4(display_short)|uniprotkb:Nik(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001239129.1|refseq:NP_001239130.1|refseq:NP_001239131.1|refseq:NP_032722.2|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-2559580|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032014"(positive regulation of ARF protein signal transduction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-40973N|mint:P97820	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:laMTX6DrOoTz4D8zxLP5ohzqKyw10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q7TMY8	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P35922	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-645094	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8K4R9	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16724654|uniprotkb:Q6ZQL3|uniprotkb:Q80VS7|uniprotkb:Q8BUC8|uniprotkb:Q8BZ79	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:dlgp5_mouse(display_long)|uniprotkb:Discs large homolog 7(gene name synonym)|uniprotkb:Disks large-associated protein DLG7(gene name synonym)|uniprotkb:Hepatoma up-regulated protein homolog(gene name synonym)|uniprotkb:Dlgap5(gene name)|psi-mi:Dlgap5(display_short)|uniprotkb:Dlg7(gene name synonym)|uniprotkb:Kiaa0008(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0023052"(signaling)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0034451"(centriolar satellite)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0051642"(centrosome localization)|refseq:NP_653136.2|interpro:IPR005026(Guanylate-kinase-associated protein)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:ZALyec8yXtYNUXNZqiSJE+AmaVM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q60865	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-647767|uniprotkb:Q6IMN3|uniprotkb:Q7TT26|uniprotkb:Q60758|uniprotkb:Q61620|ensembl:ENSMUSP00000028607|ensembl:ENSMUSP00000106777	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:capr1_mouse(display_long)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:Caprin1(gene name)|psi-mi:Caprin1(display_short)|uniprotkb:Gpiap(gene name synonym)|uniprotkb:Gpiap1(gene name synonym)|uniprotkb:Gpip137(gene name synonym)|uniprotkb:M11s1(gene name synonym)|uniprotkb:G5E5(orf name)|uniprotkb:Rng105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001104759.1|refseq:NP_001104760.1|refseq:NP_001104761.1|refseq:NP_001104762.1|refseq:NP_058019.2|ensembl:ENSMUSG00000027184(gene)|ensembl:ENSMUST00000028607(transcript)|ensembl:ENSMUST00000111147(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q60865	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:e+Dcb+82jx+CoLhlGBbdSG62dPU10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P63101	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P68254	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P68510	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-444641|uniprotkb:P11576|uniprotkb:P70198|uniprotkb:Q3TGZ9|ensembl:ENSMUSP00000019109	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:1433f_mouse(display_long)|uniprotkb:Ywhah(gene name)|psi-mi:Ywhah(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_035868.1|ensembl:ENSMUSG00000018965(gene)|ensembl:ENSMUST00000019109(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P68510|rcsb pdb:5YQG|go:"GO:0006886"(intracellular protein transport)|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:Ew2uUYIXrZ8nnP52xMnGB6KOCqc10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P61982	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-359843|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q4FK44|uniprotkb:Q3UFD6|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSMUSP00000051223|ensembl:ENSMUSP00000143631	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:1433g_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_061359.2|ensembl:ENSMUSG00000051391(gene)|ensembl:ENSMUST00000055808(transcript)|ensembl:ENSMUST00000198270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61982|reactome:R-MMU-111447|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-9614399	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P62259	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9CQV8	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-771608|uniprotkb:O70455|uniprotkb:Q3TY33|uniprotkb:Q3UAN6|ensembl:ENSMUSP00000018470	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:1433b_mouse(display_long)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Ywhab(gene name)|psi-mi:Ywhab(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_061223.2|refseq:XP_006499972.1|reactome:R-MMU-111447|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-170968|reactome:R-MMU-2028269|reactome:R-MMU-392517|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-75035|reactome:R-MMU-9614399|ensembl:ENSMUSG00000018326(gene)|ensembl:ENSMUST00000018470(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:4GNT|rcsb pdb:5F74|rcsb pdb:5WFU|rcsb pdb:5WFX	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:g94luGOxfq+Jbi0ztZ7gbAkp+2A10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8R5H6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-774719|uniprotkb:Q91W51|uniprotkb:Q9ERQ9|ensembl:ENSMUSP00000019975|ensembl:ENSMUSP00000101148	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:wasf1_mouse(display_long)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Wasf1(gene name)|psi-mi:Wasf1(display_short)|uniprotkb:Wave1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_114083.1|refseq:XP_006512995.1|ensembl:ENSMUSG00000019831(gene)|ensembl:ENSMUST00000019975(transcript)|ensembl:ENSMUST00000105509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8R5H6|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013423	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:t+4F2ap7lNjE/AGuIwMhel4YknU10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P61089	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-494560|uniprotkb:Q16781|uniprotkb:Q3TSL6|uniprotkb:Q6ZWZ0|uniprotkb:Q9DAJ6|ensembl:ENSMUSP00000096932	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:ube2n_mouse(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)|uniprotkb:Ube2n(gene name)|psi-mi:Ube2n(display_short)|uniprotkb:Blu(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_542127.1|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P61089|reactome:R-MMU-1169408|reactome:R-MMU-168638|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-5696395|reactome:R-MMU-69473|reactome:R-MMU-8866654|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-9646399|reactome:R-MMU-975144|reactome:R-MMU-983168|ensembl:ENSMUSG00000074781(gene)|ensembl:ENSMUST00000099329(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz810090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q0KL02	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16725543|uniprotkb:Q3U522|uniprotkb:Q6P9K6|uniprotkb:Q80W23	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:trio_mouse(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-MMU-193648|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418885|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|mint:Q0KL02|refseq:NP_001074771.1|refseq:XP_006520117.1|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|interpro:IPR028570	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:nUVpjuymw6gIq+G/H2xcZJh55a810090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:F7BAB2	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16725528|ensembl:ENSMUSP00000031446	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:f7bab2_mouse(display_long)|uniprotkb:Tmem132b(gene name)|psi-mi:Tmem132b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000070498(gene)|ensembl:ENSMUST00000031446(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR026307|interpro:IPR031435|interpro:IPR031436|interpro:IPR031437|refseq:NP_001177281.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:z9SczmUQw6FcojMWaUOVNb/P2go10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8CC35	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-774691|uniprotkb:Q99JI0|ensembl:ENSMUSP00000125272	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:synpo_mouse(display_long)|uniprotkb:Synpo(gene name)|psi-mi:Synpo(display_short)|uniprotkb:Kiaa1029(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000043079(gene)|ensembl:ENSMUST00000143275(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0097444"(spine apparatus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098886"(modification of dendritic spine)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099588"(positive regulation of postsynaptic cytosolic calcium concentration)|go:"GO:1905355"(spine apparatus assembly)|interpro:IPR028753	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:X85lScd6IVk7dALEA55e9/YC9Rw10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:F6SEU4	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-5797569|ensembl:ENSMUSP00000141686	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q6ZWR6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-10760754|uniprotkb:Q8K3T7|uniprotkb:Q9ERT7|uniprotkb:Q9ERT8	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:syne1_mouse(display_long)|uniprotkb:Synaptic nuclear envelope protein 1(gene name synonym)|uniprotkb:Enaptin(gene name synonym)|uniprotkb:Myocyte nuclear envelope protein 1(gene name synonym)|uniprotkb:Nuclear envelope spectrin repeat protein 1(gene name synonym)|uniprotkb:Syne1(gene name)|psi-mi:Syne1(display_short)|uniprotkb:KASH domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	mint:Q6ZWR6|refseq:NP_001073154.1|go:"GO:0000932"(P-body)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0007030"(Golgi organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030496"(midbody)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051642"(centrosome localization)|go:"GO:0061886"(negative regulation of mini excitatory postsynaptic potential)|go:"GO:0090292"(nuclear matrix anchoring at nuclear membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903353"(regulation of nucleus organization)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR012315(Klarsicht/ANC-1/syne-1 homology)|interpro:IPR018159|interpro:IPR036872|dip:DIP-60966N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:96Ke3lpwOXQNnVBWVhwJaEpeNAM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q68FG2	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2255511|ensembl:ENSMUSP00000008991	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:q68fg2_mouse(display_long)|uniprotkb:Sptbn2(gene name)|psi-mi:Sptbn2(display_short)|uniprotkb:Spnb3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_067262.1|refseq:XP_006531767.1|refseq:XP_006531768.1|ensembl:ENSMUSG00000067889(gene)|ensembl:ENSMUST00000008991(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008091"(spectrin)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0030534"(adult behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051693"(actin filament capping)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098918"(structural constituent of synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:0099189"(postsynaptic spectrin-associated cytoskeleton)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-MMU-2132295|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:2F7U0dl21KxXpc9Z2sk7D/wzQvM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q62261	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P16546	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-911063|uniprotkb:A3KGU6|uniprotkb:Q8K380|uniprotkb:Q9CT05|uniprotkb:A3KGU8|ensembl:ENSMUSP00000092697	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:sptn1_mouse(display_long)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym)|uniprotkb:Spta2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	dip:DIP-37712N|ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000095083(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032437"(cuticular plate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:P16546|reactome:R-MMU-264870|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:UVB6Kv+PBlqDH3OLoGjxm5oYVPQ10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q62417	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2365368|uniprotkb:Q80TF8|uniprotkb:Q8BZI3|uniprotkb:Q8K3Y2|uniprotkb:Q921F8|uniprotkb:Q9Z0Z8|uniprotkb:Q9Z0Z9	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:srbs1_mouse(display_long)|uniprotkb:Sorbs1(gene name)|psi-mi:Sorbs1(display_short)|uniprotkb:Kiaa1296(gene name synonym)|uniprotkb:Sh3d5(gene name synonym)|uniprotkb:Ponsin(gene name synonym)|uniprotkb:c-Cbl-associated protein(gene name synonym)|uniprotkb:SH3 domain protein 5(gene name synonym)|uniprotkb:SH3P12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001030134.1|refseq:NP_001030135.1|refseq:NP_001030136.1|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|interpro:IPR035606|interpro:IPR035610|interpro:IPR035611|interpro:IPR036028|mint:Q62417|go:"GO:0001725"(stress fiber)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016600"(flotillin complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|reactome:R-MMU-445355	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:3+0ZfSkNB+9ujOF3uyXmP2ovl8A10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q61548	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-775174|uniprotkb:Q61547|uniprotkb:Q8K0D4	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:ap180_mouse(display_long)|uniprotkb:Clathrin coat-associated protein AP180(gene name synonym)|uniprotkb:91 kDa synaptosomal-associated protein(gene name synonym)|uniprotkb:Phosphoprotein F1-20(gene name synonym)|uniprotkb:Snap91(gene name)|psi-mi:Snap91(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001264911.1|refseq:NP_001264915.1|refseq:NP_038697.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|refseq:XP_006510957.1|refseq:XP_006510963.1|interpro:IPR030428|mint:Q61548|go:"GO:0000149"(SNARE binding)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043679"(axon terminus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1904006"(negative regulation of phospholipase D activity)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|reactome:R-MMU-8856825|reactome:R-MMU-8856828	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:uew/lk0YJ8j0CQULEZaC/qLlLF810090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:A2AQ25	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-8821027|ensembl:ENSMUSP00000066170|uniprotkb:A2AUE9|uniprotkb:A2AUF0|uniprotkb:A2AUF1|uniprotkb:Q75UV8|uniprotkb:Q75UV9|uniprotkb:Q80VK2|uniprotkb:Q8BHX8|uniprotkb:Q8BHY1|uniprotkb:Q8CHA8|uniprotkb:Q8R0K6	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:skt_mouse(display_long)|uniprotkb:Skt(gene name)|psi-mi:Skt(display_short)|uniprotkb:Etl4(gene name synonym)|uniprotkb:Kiaa1217(gene name synonym)|uniprotkb:Enhancer trap locus 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	interpro:IPR022782|interpro:IPR026725|mint:A2AQ25|ensembl:ENSMUSG00000036617(gene)|ensembl:ENSMUST00000066509(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0048706"(embryonic skeletal system development)|refseq:NP_001074475.1|refseq:NP_001171101.2|refseq:NP_084171.2|refseq:NP_835160.2|refseq:XP_006497478.1|refseq:XP_006497487.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:WI45C2F/GFoa1PhVnBHPtxCj5mM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q4ACU6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q80Z38	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-770338|uniprotkb:E9QPH7|uniprotkb:Q3UTK4|uniprotkb:Q5DU07	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:shan2_mouse(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)|uniprotkb:Kiaa1022(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001074839.2|refseq:NP_001106844.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001452(Src homology-3)|refseq:XP_006508596.1|reactome:R-MMU-6794361|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0043005"(neuron projection)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:OTohbAMxKtx7/WWwWXDc+c24HvQ10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:D3YZU1	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2314988|ensembl:ENSMUSP00000103571	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:shan1_mouse(display_long)|uniprotkb:Shank1(gene name)|psi-mi:Shank1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001029287.1|refseq:XP_006540927.1|ensembl:ENSMUSG00000038738(gene)|ensembl:ENSMUST00000107938(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:TbxBmjjabypLqTlAx9zbkSAAzpk10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8R550	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-642709|uniprotkb:Q8CAL8|uniprotkb:Q8CEF6|uniprotkb:Q8R545|uniprotkb:Q8R546|uniprotkb:Q8R547|uniprotkb:Q8R548|uniprotkb:Q8R549|uniprotkb:Q8R551|uniprotkb:Q9CTQ9|uniprotkb:Q9DC14|uniprotkb:Q9JKC3|uniprotkb:B1AZ86|uniprotkb:B1AZ87|ensembl:ENSMUSP00000072840	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:sh3k1_mouse(display_long)|uniprotkb:SH3-containing, expressed in tumorigenic astrocytes(gene name synonym)|uniprotkb:Regulator of ubiquitous kinase(gene name synonym)|uniprotkb:Sh3kbp1(gene name)|psi-mi:Sh3kbp1(display_short)|uniprotkb:Ruk(gene name synonym)|uniprotkb:Seta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001129199.1|refseq:NP_001129200.1|refseq:NP_067364.2|refseq:XP_006528987.1|ensembl:ENSMUSG00000040990(gene)|ensembl:ENSMUST00000073094(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q8R550|rcsb pdb:1WI7|rcsb pdb:2DA9|rcsb pdb:5XHZ|reactome:R-MMU-182971|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866376|reactome:R-MMU-983695|refseq:XP_011246151.1|refseq:XP_011246153.1|refseq:NP_001277590.1|refseq:NP_001277593.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:Fd7WikE+fZIgob7Ax2vr9J291N010090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:O55131	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-772161	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:sept7_mouse(display_long)|uniprotkb:Septin7(gene name)|psi-mi:Septin7(display_short)|uniprotkb:CDC10 protein homolog(gene name synonym)|uniprotkb:Cdc10(gene name synonym)|uniprotkb:Sept7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001192296.1|interpro:IPR016491(Septin)|interpro:IPR008115(Septin 7)|interpro:IPR030379|interpro:IPR027417|mint:O55131|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0005938"(cell cortex)|go:"GO:0005940"(septin ring)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0030496"(midbody)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031105"(septin complex)|go:"GO:0031270"(pseudopodium retraction)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032156"(septin cytoskeleton)|go:"GO:0032160"(septin filament array)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0048668"(collateral sprouting)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|reactome:R-MMU-5687128	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:VULb4UyoWVn5vRWIzERa9YQJIYo10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9Z2Q6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-772125|uniprotkb:Q3UYG4|uniprotkb:Q6PB74|uniprotkb:B2RUC5|ensembl:ENSMUSP00000094750	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:sept5_mouse(display_long)|uniprotkb:Septin5(gene name)|psi-mi:Septin5(display_short)|uniprotkb:Cell division control-related protein 1(gene name synonym)|uniprotkb:Peanut-like protein 1(gene name synonym)|uniprotkb:Pnutl1(gene name synonym)|uniprotkb:Sept5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_998779.2|ensembl:ENSMUSG00000072214(gene)|ensembl:ENSMUST00000096987(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0005940"(septin ring)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030534"(adult behavior)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035176"(social behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0045202"(synapse)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098793"(presynapse)|go:"GO:0099148"(regulation of synaptic vesicle docking)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030647|mint:Q9Z2Q6	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:9ZY1BrCZ/7+83bn/q3OQkZoi8pg10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9Z1S5	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-772112|uniprotkb:Q3TNZ2|uniprotkb:Q7TNT7	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:sept3_mouse(display_long)|uniprotkb:Septin3(gene name)|psi-mi:Septin3(display_short)|uniprotkb:Sep3(gene name synonym)|uniprotkb:Sept3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_036019.2|interpro:IPR016491(Septin)|interpro:IPR008114(Septin 3)|interpro:IPR030379|interpro:IPR027417|mint:Q9Z1S5|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005940"(septin ring)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098793"(presynapse)|go:"GO:0099569"(presynaptic cytoskeleton)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:bh+Ipxn2l+rYj60pLw1/8IB04qw10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P42208	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-772099|uniprotkb:Q3U9Y5|uniprotkb:B2RRZ2|ensembl:ENSMUSP00000027495|ensembl:ENSMUSP00000132850|ensembl:ENSMUSP00000136366	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:sept2_mouse(display_long)|uniprotkb:Sept2(gene name synonym)|uniprotkb:Septin2(gene name)|psi-mi:Septin2(display_short)|uniprotkb:Nedd5(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001153189.1|refseq:NP_001153190.1|refseq:NP_001153191.1|refseq:NP_035021.1|refseq:XP_006529304.1|refseq:XP_006529305.1|dip:DIP-32438N|ensembl:ENSMUSG00000026276(gene)|ensembl:ENSMUSG00000116048(gene)|ensembl:ENSMUST00000027495(transcript)|ensembl:ENSMUST00000168776(transcript)|ensembl:ENSMUST00000179353(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0000776"(kinetochore)|go:"GO:0002036"(regulation of L-glutamate import across plasma membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0005938"(cell cortex)|go:"GO:0005940"(septin ring)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051258"(protein polymerization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|interpro:IPR008113(Septin 2)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|rcsb pdb:3FTQ|reactome:R-MMU-5620912|mint:P42208	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:vk7UVRzpfbNxL4cxXJhd94mfQxc10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8C1B7	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-772076|uniprotkb:Q3TBA0|uniprotkb:Q3TC24|uniprotkb:Q5D0F0|uniprotkb:Q6P2K5|uniprotkb:Q6P6I0|ensembl:ENSMUSP00000143928	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:sep11_mouse(display_long)|uniprotkb:Septin11(gene name)|psi-mi:Septin11(display_short)|uniprotkb:D5Ertd606e(gene name synonym)|uniprotkb:Sept11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001009818.1|refseq:NP_001297598.1|refseq:NP_001297600.1|ensembl:ENSMUSG00000058013(gene)|ensembl:ENSMUST00000201421(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005940"(septin ring)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099629"(postsynaptic specialization of symmetric synapse)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|mint:Q8C1B7	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:RfdukqyhC/1qeJHPQmrz7ryDmdY10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:E9PW37	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16725503|ensembl:ENSMUSP00000077423	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:e9pw37_mouse(display_long)|uniprotkb:Rasal2(gene name)|psi-mi:Rasal2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000070565(gene)|ensembl:ENSMUST00000078308(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0007165"(signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR039360|reactome:R-MMU-5658442|reactome:R-MMU-9696264|reactome:R-MMU-9696273|refseq:NP_808312.3	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:ZIal1IuCekt9MxN5+SgsQJnrcsM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9EQZ6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-772212|uniprotkb:Q8VIP9|uniprotkb:Q9CW52|uniprotkb:Q9Z1P0|ensembl:ENSMUSP00000088336	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:rpgf4_mouse(display_long)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor II(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 2(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 2(gene name synonym)|uniprotkb:cAMP-dependent Rap1 guanine-nucleotide exchange factor(gene name synonym)|uniprotkb:Rapgef4(gene name)|psi-mi:Rapgef4(display_short)|uniprotkb:Cgef2(gene name synonym)|uniprotkb:Epac2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_062662.1|refseq:NP_001191094.1|refseq:NP_001191095.1|dip:DIP-32333N|ensembl:ENSMUSG00000049044(gene)|ensembl:ENSMUST00000090826(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030552"(cAMP binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044316"(cone cell pedicle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1904457"(positive regulation of neuronal action potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|rcsb pdb:1O7F|rcsb pdb:2BYV|rcsb pdb:3CF6|rcsb pdb:4F7Z|rcsb pdb:4MGI|rcsb pdb:4MGK|rcsb pdb:4MGY|rcsb pdb:4MGZ|rcsb pdb:4MH0|reactome:R-MMU-354192|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:E6oFNR3wXazvvq3wWWxfn4CW5F410090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P62835	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-1634972|uniprotkb:P10113|ensembl:ENSMUSP00000088174	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:rap1a_mouse(display_long)|uniprotkb:Rap1a(gene name)|psi-mi:Rap1a(display_short)|uniprotkb:Krev-1(gene name synonym)|uniprotkb:Ras-related protein Krev-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_663516.1|refseq:XP_006500970.1|ensembl:ENSMUSG00000068798(gene)|ensembl:ENSMUST00000090678(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0030054"(cell junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0035690"|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:0097421"(liver regeneration)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|mint:P62835|reactome:R-MMU-170968|reactome:R-MMU-170984|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-5674135|reactome:R-MMU-6798695|reactome:R-MMU-8875555	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:QtjMjJiMQF0CbTD40IZgca4XfIU10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P63001	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P62821	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-1634955|uniprotkb:P11476|uniprotkb:Q3TX44|uniprotkb:Q811M4|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|ensembl:ENSMUSP00000127330	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:rab1a_mouse(display_long)|uniprotkb:Rab1A(gene name)|psi-mi:Rab1A(display_short)|uniprotkb:Rab1(gene name synonym)|uniprotkb:YPT1-related protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_033022.1|ensembl:ENSMUSG00000020149(gene)|ensembl:ENSMUST00000163483(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043025"(neuronal cell body)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0098793"(presynapse)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62821|reactome:R-MMU-162658|reactome:R-MMU-204005|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-8873719|reactome:R-MMU-8876198	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf010090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P42669	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-773823|ensembl:ENSMUSP00000059404	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:pura_mouse(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:Pura(gene name)|psi-mi:Pura(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_033015.1|refseq:XP_006525787.1|refseq:XP_011245162.1|ensembl:ENSMUSG00000043991(gene)|ensembl:ENSMUST00000051301(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:P42669	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:3LVZ5qdZYeJyeUVPhy3cozxROWs10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P34152	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-77070|uniprotkb:Q5DTH7|uniprotkb:Q8C513|uniprotkb:Q8CFH7|uniprotkb:Q8CHM2|uniprotkb:Q8K2S0|uniprotkb:Q9DAW3|intact:EBI-644981|uniprotkb:O08578|ensembl:ENSMUSP00000105663	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:fak1_mouse(display_long)|uniprotkb:Ptk2(gene name)|psi-mi:Ptk2(display_short)|uniprotkb:Fadk(gene name synonym)|uniprotkb:Fak(gene name synonym)|uniprotkb:Fak1(gene name synonym)|uniprotkb:Kiaa4203(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001123881.1|refseq:NP_032008.2|refseq:XP_006520496.1|dip:DIP-31045N|ensembl:ENSMUSG00000022607(gene)|ensembl:ENSMUST00000110036(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001764"(neuron migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007097"(nuclear migration)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:P34152|rcsb pdb:1K40|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:5F28|rcsb pdb:6BZ3|reactome:R-MMU-111465|reactome:R-MMU-2029482|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-375165|reactome:R-MMU-3928662|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-8874081|reactome:R-MMU-9009391	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:ZO/rmkDeJv5vec4ug3C3YrIwSIM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P63318	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-397096|uniprotkb:P05697|ensembl:ENSMUSP00000097874	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kpcg_mouse(display_long)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_035232.1|ensembl:ENSMUSG00000078816(gene)|ensembl:ENSMUST00000100301(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0005829"(cytosol)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|interpro:IPR020454|interpro:IPR035892|mint:P63318|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-416993|reactome:R-MMU-5099900|reactome:R-MMU-76005	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P68404	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P48453	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-642618|uniprotkb:Q6NZR4|ensembl:ENSMUSP00000125722	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:pp2bb_mouse(display_long)|uniprotkb:Calmodulin-dependent calcineurin A subunit beta isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Ppp3cb(gene name)|psi-mi:Ppp3cb(display_short)|uniprotkb:Calnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_032940.1|refseq:NP_001297355.1|refseq:NP_001297356.1|ensembl:ENSMUSG00000021816(gene)|ensembl:ENSMUST00000159027(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P48453|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|go:"GO:0005516"(calmodulin binding)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:YD7q3dcL87htgwHRd5m5ReMlqd010090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P63328	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-397208|uniprotkb:P12816|uniprotkb:P20652|uniprotkb:Q3UCU1|uniprotkb:Q64135|ensembl:ENSMUSP00000053101	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:pp2ba_mouse(display_long)|uniprotkb:Ppp3ca(gene name)|psi-mi:Ppp3ca(display_short)|uniprotkb:Calna(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_032939.1|refseq:NP_001280551.1|ensembl:ENSMUSG00000028161(gene)|ensembl:ENSMUST00000056758(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042383"(sarcolemma)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P63328|rcsb pdb:4ORB|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|dip:DIP-31543N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:98yAyDGZZxKYOv22ejceyfJbvao10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P63087	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-80040|uniprotkb:O09186|uniprotkb:O09189|uniprotkb:P37139|uniprotkb:Q64679|ensembl:ENSMUSP00000099587	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:pp1g_mouse(display_long)|uniprotkb:Ppp1cc(gene name)|psi-mi:Ppp1cc(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|rcsb pdb:4V0U|rcsb pdb:4V0V|rcsb pdb:4V0W|rcsb pdb:4V0X|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-68877|reactome:R-MMU-9648025|go:"GO:0005856"(cytoskeleton)|ensembl:ENSMUSG00000004455(gene)|ensembl:ENSMUST00000102528(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_038664.2|refseq:XP_006508478.1|refseq:XP_006530263.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:67YjuOIxqIl6Qj+bQnfLBo4iRAg10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:B1AWC9	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16725459|ensembl:ENSMUSP00000102524	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:b1awc9_mouse(display_long)|uniprotkb:Pde4b(gene name)|psi-mi:Pde4b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000028525(gene)|ensembl:ENSMUST00000106911(transcript)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006198"(cAMP catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009408"(response to heat)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030552"(cAMP binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035690"|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0060076"(excitatory synapse)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1901898"(negative regulation of relaxation of cardiac muscle)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|go:"GO:0000930"(gamma-tubulin complex)|interpro:IPR023174|interpro:IPR036971|interpro:IPR040844|interpro:IPR043371|reactome:R-MMU-180024|go:"GO:0001780"(neutrophil homeostasis)|refseq:XP_006502918.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:7CrVN5FTm9YCqaXg9IMdWcahW+k10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P08551	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-445199|uniprotkb:Q8K0Z0|ensembl:ENSMUSP00000022639	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:nfl_mouse(display_long)|uniprotkb:Neurofilament triplet L protein(gene name synonym)|uniprotkb:68 kDa neurofilament protein(gene name synonym)|uniprotkb:Nefl(gene name)|psi-mi:Nefl(display_short)|uniprotkb:Nfl(gene name synonym)|uniprotkb:Nf68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_035040.1|ensembl:ENSMUSG00000022055(gene)|ensembl:ENSMUST00000022639(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027692|interpro:IPR039008|mint:P08551|reactome:R-MMU-438066|reactome:R-MMU-5673001|go:"GO:0098981"(cholinergic synapse)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0040011"(locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051258"(protein polymerization)|go:"GO:0051412"(response to corticosterone)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060074"(synapse maturation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|dip:DIP-31944N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:E8KK2ppZXyLXIlFZp/pjXv7GBEU10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P19246	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-1634658|uniprotkb:A1E2H9|uniprotkb:Q5SVF6|uniprotkb:Q61959|ensembl:ENSMUSP00000091061	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:nfh_mouse(display_long)|uniprotkb:Nefh(gene name)|psi-mi:Nefh(display_short)|uniprotkb:Kiaa0845(gene name synonym)|uniprotkb:Nfh(gene name synonym)|uniprotkb:Neurofilament triplet H protein(gene name synonym)|uniprotkb:200 kDa neurofilament protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_035034.2|ensembl:ENSMUSG00000020396(gene)|ensembl:ENSMUST00000093369(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001552"(ovarian follicle atresia)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0007420"(brain development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015643"(toxic substance binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031103"(axon regeneration)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0061564"(axon development)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:0150017"(basal proximal dendrite)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR010790(Protein of unknown function DUF1388)|interpro:IPR018039|interpro:IPR033183|interpro:IPR039008|mint:P19246	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:1Fs10v+/s87EA3iRKeuxNEijJ5o10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P28660	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9Z0E0	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-775082|uniprotkb:Q3TCW4|uniprotkb:Q80TW1|uniprotkb:Q91YH7|uniprotkb:Q9CW81|uniprotkb:Q9QUQ0|ensembl:ENSMUSP00000030637|ensembl:ENSMUSP00000101722	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:ncdn_mouse(display_long)|uniprotkb:Sfap75(gene name synonym)|uniprotkb:Norbin(gene name synonym)|uniprotkb:M-Sema F-associating protein of 75 kDa(gene name synonym)|uniprotkb:Ncdn(gene name)|psi-mi:Ncdn(display_short)|uniprotkb:Kiaa0607(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_036116.3|refseq:XP_006503181.1|refseq:XP_006503182.1|ensembl:ENSMUSG00000028833(gene)|ensembl:ENSMUST00000030637(transcript)|ensembl:ENSMUST00000106116(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045453"(bone resorption)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0098794"(postsynapse)|interpro:IPR008709(Neurochondrin)|interpro:IPR016024(Armadillo-type fold)|mint:Q9Z0E0	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:afzLC/h+kiexMllkeyxpn1btb1U10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9EPN1	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-527731|uniprotkb:Q8C931|uniprotkb:Q9EPM9|uniprotkb:Q9EPN0|uniprotkb:Q9WVM9|ensembl:ENSMUSP00000029374	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:nbea_mouse(display_long)|uniprotkb:Lysosomal-trafficking regulator 2(gene name synonym)|uniprotkb:Nbea(gene name)|psi-mi:Nbea(display_short)|uniprotkb:Lyst2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_085098.1|ensembl:ENSMUSG00000027799(gene)|ensembl:ENSMUST00000029374(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0008104"(protein localization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR010508(Protein of unknown function DUF1088)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023362|interpro:IPR031570|interpro:IPR036322|interpro:IPR036372|mint:Q9EPN1|refseq:XP_006501586.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:NWSzMiK/aQ6zHqkCxAoWJSqnrvA10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P97434	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2365654|uniprotkb:Q3TBR5|uniprotkb:Q3TC85|uniprotkb:Q3TRS0|uniprotkb:Q3U1Y8|uniprotkb:Q3U3E4|uniprotkb:Q5SWZ3|uniprotkb:Q5SWZ4|uniprotkb:Q5SWZ7|uniprotkb:Q6P559|uniprotkb:Q80YC8|ensembl:ENSMUSP00000112072	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:mprip_mouse(display_long)|uniprotkb:Mprip(gene name)|psi-mi:Mprip(display_short)|uniprotkb:Kiaa0864(gene name synonym)|uniprotkb:Mrip(gene name synonym)|uniprotkb:Rhoip3(gene name synonym)|uniprotkb:Rho-interacting protein 3(gene name synonym)|uniprotkb:p116Rip(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_036157.2|refseq:NP_957697.1|refseq:XP_006533503.1|ensembl:ENSMUSG00000005417(gene)|ensembl:ENSMUST00000116371(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0051015"(actin filament binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039597|mint:P97434	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:jwOKcVLEosfXdMVQ5LfEjkan/U410090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9JM52	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-645434|uniprotkb:Q5SXG2|uniprotkb:Q921M6|uniprotkb:Q9JM92|ensembl:ENSMUSP00000099619	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:mink1_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase kinase kinase kinase 6(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 6(gene name synonym)|uniprotkb:Misshapen/NIK-related kinase(gene name synonym)|uniprotkb:GCK family kinase MiNK(gene name synonym)|uniprotkb:Mink1(gene name)|psi-mi:Mink1(display_short)|uniprotkb:Map4k6(gene name synonym)|uniprotkb:Mink(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_795712.2|refseq:XP_006533744.1|refseq:NP_057922.2|ensembl:ENSMUSG00000020827(gene)|ensembl:ENSMUST00000102559(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007275"(multicellular organism development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000311"(regulation of AMPA receptor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9JM52|reactome:R-MMU-2559580	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:Kuk8yQcHbIShH9SwsEkvyMTVcMw10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q63844	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-397682|uniprotkb:Q61531|uniprotkb:Q8K0X5|uniprotkb:Q91YW5|ensembl:ENSMUSP00000051619	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:mk03_mouse(display_long)|uniprotkb:Mapk3(gene name)|psi-mi:Mapk3(display_short)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:MNK1(gene name synonym)|uniprotkb:Erk1(gene name synonym)|uniprotkb:Prkm3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_036082.1|dip:DIP-31078N|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0014032"(neural crest cell development)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|ensembl:ENSMUSG00000063065(gene)|ensembl:ENSMUST00000057669(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|reactome:R-MMU-9627069|reactome:R-MMU-982772|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63844|reactome:R-MMU-110056|reactome:R-MMU-112409|reactome:R-MMU-1169408|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6811558|reactome:R-MMU-73728|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:I2hStA4IjS6t6Ky7fb9zFPOcZag10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P63085	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8K377	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2314899|uniprotkb:Q3UVX1|ensembl:ENSMUSP00000020400|ensembl:ENSMUSP00000124373|ensembl:ENSMUSP00000125207	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:lrrt1_mouse(display_long)|uniprotkb:Lrrtm1(gene name)|psi-mi:Lrrtm1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_083156.2|refseq:XP_006506775.1|ensembl:ENSMUSG00000060780(gene)|ensembl:ENSMUST00000020400(transcript)|ensembl:ENSMUST00000159616(transcript)|ensembl:ENSMUST00000161677(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007626"(locomotory behavior)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035640"(exploration behavior)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-MMU-6794361|go:"GO:0099151"(regulation of postsynaptic density assembly)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:mC6rwAk8WrxjH0Ph59e5IQTwcEM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q80TE7	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-774900	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:lrrc7_mouse(display_long)|uniprotkb:Protein LAP1(gene name synonym)|uniprotkb:Densin-180(gene name synonym)|uniprotkb:Lrrc7(gene name)|psi-mi:Lrrc7(display_short)|uniprotkb:Kiaa1365(gene name synonym)|uniprotkb:Lap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001278381.1|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR032675|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR036034|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6798695|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043194"(axon initial segment)|go:"GO:0043197"(dendritic spine)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:QWCdfe/eQM/ZaaAG2GwZi+Rf87Q10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q80X72	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16725433|ensembl:ENSMUSP00000066777	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:lrc15_mouse(display_long)|uniprotkb:Lrrc15(gene name)|psi-mi:Lrrc15(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000052316(gene)|ensembl:ENSMUST00000064606(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0043236"(laminin binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|refseq:NP_083249.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:YnwGQKhve3tOWPVVJh/ZClhjkwI10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9JIA1	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-445256|ensembl:ENSMUSP00000143128	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:lgi1_mouse(display_long)|uniprotkb:Lgi1(gene name)|psi-mi:Lgi1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_064674.1|ensembl:ENSMUSG00000067242(gene)|ensembl:ENSMUST00000198518(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007411"(axon guidance)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031175"(neuron projection development)|go:"GO:0043083"(synaptic cleft)|go:"GO:0045202"(synapse)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005492(EPTP)|interpro:IPR009039(EAR)|interpro:IPR032675|mint:Q9JIA1|reactome:R-MMU-5682910	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:PEM1comV+IMxsMdEb0dRsl2+pqg10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P28738	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2506834|uniprotkb:Q6NXI9|ensembl:ENSMUSP00000028102|uniprotkb:Q9Z2F8	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kif5c_mouse(display_long)|uniprotkb:Kif5c(gene name)|psi-mi:Kif5c(display_short)|uniprotkb:Nkhc2(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000026764(gene)|ensembl:ENSMUST00000028102(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051028"(mRNA transport)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098964"(anterograde dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0150034"(distal axon)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:P28738|rcsb pdb:1VFV|rcsb pdb:1VFW|rcsb pdb:1VFX|rcsb pdb:1VFZ|rcsb pdb:3J6H|rcsb pdb:3WRD|rcsb pdb:3X2T|rcsb pdb:5HLE|refseq:NP_032475.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:GbPyKDztqPG8BP2+44k3TXPuI/010090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P33175	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-349710|uniprotkb:Q5DTP1|uniprotkb:Q6PDY7|uniprotkb:Q9Z2F9|ensembl:ENSMUSP00000096775|ensembl:ENSMUSP00000151402	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kif5a_mouse(display_long)|uniprotkb:Kif5a(gene name)|psi-mi:Kif5a(display_short)|uniprotkb:Kiaa4086(gene name synonym)|uniprotkb:Kif5(gene name synonym)|uniprotkb:Neuronal kinesin heavy chain(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 1(gene name synonym)|uniprotkb:Nkhc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001034089.1|refseq:NP_032473.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P33175|reactome:R-MMU-2132295|reactome:R-MMU-5625970|reactome:R-MMU-6811434|reactome:R-MMU-983189|ensembl:ENSMUSG00000074657(gene)|ensembl:ENSMUST00000099172(transcript)|ensembl:ENSMUST00000217895(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:otK0LxjRwOuSLqL6iOEI+7BY+SI10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P52189	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2309692	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kcnj4_mouse(display_long)|uniprotkb:Kcnj4(gene name)|psi-mi:Kcnj4(display_short)|uniprotkb:Irk3(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 4(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir2.3"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR003273(Potassium channel, inwardly rectifying, Kir2.3)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR040445|interpro:IPR041647|reactome:R-MMU-1296041|reactome:R-MMU-1296053|reactome:R-MMU-5576886|reactome:R-MMU-997272|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:o71idIrcU8IP7uaiSD/QJ/1NiBk10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9JM63	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2309655|ensembl:ENSMUSP00000054356	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kcj10_mouse(display_long)|uniprotkb:Kcnj10(gene name)|psi-mi:Kcnj10(display_short)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 10(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir4.1"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001034573.1|refseq:XP_006496740.2|ensembl:ENSMUSG00000044708(gene)|ensembl:ENSMUST00000056136(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0044297"(cell body)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051935"(glutamate reuptake)|go:"GO:0051938"(L-glutamate import)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097546"(ciliary base)|go:"GO:0098793"(presynapse)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR003269(Potassium channel, inwardly rectifying, Kir1.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:Q9JM63|reactome:R-MMU-1296041|reactome:R-MMU-1296067|reactome:R-MMU-997272	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:xYsrr3gfPI6Dob9k78XGFz3Pp2410090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P63143	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2311348|uniprotkb:Q91WM5|uniprotkb:P97380|uniprotkb:Q61763|uniprotkb:Q63277|ensembl:ENSMUSP00000047480	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kcab1_mouse(display_long)|uniprotkb:Kcnab1(gene name)|psi-mi:Kcnab1(display_short)|uniprotkb:Kvb1(gene name synonym)|uniprotkb:"K(+) channel subunit beta-1"(gene name synonym)|uniprotkb:Kv-beta-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_034727.3|ensembl:ENSMUSG00000027827(gene)|ensembl:ENSMUST00000049230(transcript)|go:"GO:0004033"("aldo-keto reductase (NADP) activity")|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007611"(learning or memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034705"(potassium channel complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|go:"GO:0070402"(NADPH binding)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1903817"(negative regulation of voltage-gated potassium channel activity)|go:"GO:1990635"(proximal dendrite)|interpro:IPR005399(Potassium channel, voltage-dependent, beta subunit, KCNAB-related)|interpro:IPR005400(Potassium channel, voltage-dependent, beta subunit, KCNAB1)|interpro:IPR005983(Potassium channel, voltage-dependent, beta subunit, KCNAB)|interpro:IPR023210|interpro:IPR036812|reactome:R-MMU-1296072	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:795ewCikN88RrzXAcw5WB7Jv4qI10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q61423	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2309633|uniprotkb:Q8CBF8|ensembl:ENSMUSP00000037958	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kcna4_mouse(display_long)|uniprotkb:Kcna4(gene name)|psi-mi:Kcna4(display_short)|uniprotkb:Voltage-gated potassium channel subunit Kv1.4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_067250.2|refseq:XP_006498875.1|ensembl:ENSMUSG00000042604(gene)|ensembl:ENSMUST00000037012(transcript)|go:"GO:0005216"(ion channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR012897(Potassium channel, voltage dependent, Kv1.4, tandem inactivation)|interpro:IPR020467|interpro:IPR027359|interpro:IPR028325|interpro:IPR037065|reactome:R-MMU-1296072	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:kLzL2QUiIqbJX3FwQ8RNPL9rxac10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P63141	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-644033|uniprotkb:P15386|uniprotkb:Q02010|uniprotkb:Q8C8W4|uniprotkb:B2RS05|ensembl:ENSMUSP00000041702|ensembl:ENSMUSP00000142873|ensembl:ENSMUSP00000143798	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kcna2_mouse(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.2(gene name synonym)|uniprotkb:Kcna2(gene name)|psi-mi:Kcna2(display_short)|uniprotkb:MK2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_032443.3|ensembl:ENSMUSG00000040724(gene)|ensembl:ENSMUST00000038695(transcript)|ensembl:ENSMUST00000196403(transcript)|ensembl:ENSMUST00000197470(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019894"(kinesin binding)|go:"GO:0021633"(optic nerve structural organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033010"(paranodal junction)|go:"GO:0034705"(potassium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044305"(calyx of Held)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004049(Potassium channel, voltage dependent, Kv1.2)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|rcsb pdb:5WIE|reactome:R-MMU-1296072|refseq:XP_006501113.1|refseq:XP_006501114.1|refseq:XP_006501111.1|refseq:XP_006501112.1|refseq:XP_006501115.1|refseq:XP_006501116.1|refseq:XP_006501117.1|refseq:XP_006501118.1|dip:DIP-32239N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:AimFojHr+yjzzdtmfxUCRBTvJyc10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P16388	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2309589|ensembl:ENSMUSP00000055225|ensembl:ENSMUSP00000144947	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kcna1_mouse(display_long)|uniprotkb:Kcna1(gene name)|psi-mi:Kcna1(display_short)|uniprotkb:Voltage-gated potassium channel subunit Kv1.1(gene name synonym)|uniprotkb:MKI(gene name synonym)|uniprotkb:MBK1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_034725.3|ensembl:ENSMUSG00000047976(gene)|ensembl:ENSMUST00000055168(transcript)|ensembl:ENSMUST00000203094(transcript)|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0021766"(hippocampus development)|go:"GO:0023041"(neuronal signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034705"(potassium channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044305"(calyx of Held)|go:"GO:0045202"(synapse)|go:"GO:0050905"(neuromuscular process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050976"(detection of mechanical stimulus involved in sensory perception of touch)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099508"(voltage-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|go:"GO:1905030"(voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004048(Potassium channel, voltage dependent, Kv1.1)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|mint:P16388|reactome:R-MMU-1296072|go:"GO:0034613"(cellular protein localization)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:jWMZN1sE3o5n4oah+dtPVzhAJPk10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:A2CG49	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-770321|uniprotkb:A2CG50|uniprotkb:A2CG51|uniprotkb:A2CG52|uniprotkb:A2CG53|uniprotkb:Q3TYL1|uniprotkb:Q3UTA5|uniprotkb:Q8BTT9|uniprotkb:Q8C4Q2|uniprotkb:Q9CVA9|uniprotkb:Q3TXY8|uniprotkb:B2RXR5|uniprotkb:D3Z559|ensembl:ENSMUSP00000076088	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:kalrn_mouse(display_long)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001157740.1|refseq:XP_006522445.1|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018159|interpro:IPR028570|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSMUSG00000061751(gene)|ensembl:ENSMUST00000076810(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0035176"(social behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042711"(maternal behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046959"(habituation)|mint:A2CG49|rcsb pdb:1WFW|reactome:R-MMU-193648|reactome:R-MMU-3928662|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5687128|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013408|interpro:IPR036865	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:pDqdA2QNbqgLE3eYQXVVW2cxIyo10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q3TES0	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16725408|ensembl:ENSMUSP00000038653|uniprotkb:Q3UHP8|uniprotkb:Q80TJ8	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:iqec3_mouse(display_long)|uniprotkb:Iqsec3(gene name)|psi-mi:Iqsec3(display_short)|uniprotkb:Kiaa1110(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000040797(gene)|ensembl:ENSMUST00000046373(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050808"(synapse organization)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099629"(postsynaptic specialization of symmetric synapse)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR033742|interpro:IPR035999|go:"GO:0060077"(inhibitory synapse)|refseq:NP_001028526.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:ca8BfkMISVCn8R1jxdoGGFCJd3s10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q5DU25	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-773452|uniprotkb:E9QK46	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:iqec2_mouse(display_long)|uniprotkb:Iqsec2(gene name)|psi-mi:Iqsec2(display_short)|uniprotkb:Kiaa0522(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000904(SEC7-like)|interpro:IPR023394|interpro:IPR033742|refseq:XP_006528908.1|interpro:IPR035999|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900454"(positive regulation of long-term synaptic depression)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:D2kDV/pgwPkXPHcK5+7S9+HS6Wk10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q8R0S2	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-772277|uniprotkb:Q3TZC3|uniprotkb:Q5DU15|ensembl:ENSMUSP00000098712	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:iqec1_mouse(display_long)|uniprotkb:Iqsec1(gene name)|psi-mi:Iqsec1(display_short)|uniprotkb:Kiaa0763(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001127855.1|ensembl:ENSMUSG00000034312(gene)|ensembl:ENSMUST00000101153(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR030737|interpro:IPR033742|interpro:IPR035999	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:BZg7CaLndE4ak8KXs34YFf9iBRQ10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q3UQ44	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16724715|ensembl:ENSMUSP00000067685	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:iqga2_mouse(display_long)|uniprotkb:Iqgap2(gene name)|psi-mi:Iqgap2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000021676(gene)|ensembl:ENSMUST00000068603(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005902"(microvillus)|go:"GO:0009986"(cell surface)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR036872|reactome:R-MMU-5626467|reactome:R-MMU-6798695|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013408|refseq:NP_081987.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:YD6GurtWVrIzYEBzXb7fdJ6qAWI10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9Z2Y3	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P13020	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-445180|uniprotkb:Q3UPB1|uniprotkb:Q8R590|intact:EBI-4281654|ensembl:ENSMUSP00000028239	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:gels_mouse(display_long)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Brevin(gene name synonym)|uniprotkb:Gsn(gene name)|psi-mi:Gsn(display_short)|uniprotkb:Gsb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_666232.2|ensembl:ENSMUSG00000026879(gene)|ensembl:ENSMUST00000028239(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030478"(actin cap)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036313"(phosphatidylinositol 3-kinase catalytic subunit binding)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043209"(myelin sheath)|go:"GO:0045010"(actin nucleation)|go:"GO:0045159"(myosin II binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0051593"(response to folic acid)|go:"GO:0051693"(actin filament capping)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060271"(cilium assembly)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0097017"(renal protein absorption)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1903903"(regulation of establishment of T cell polarity)|go:"GO:1903906"(regulation of plasma membrane raft polarization)|go:"GO:1903909"(regulation of receptor clustering)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR030004|mint:P13020|rcsb pdb:1NPH|rcsb pdb:4CBU|rcsb pdb:4CBW|rcsb pdb:4CBX|rcsb pdb:5MVV|rcsb pdb:6I4D|rcsb pdb:6I4E|rcsb pdb:6I4F|rcsb pdb:6I4G|rcsb pdb:6I4H|rcsb pdb:6I4I|rcsb pdb:6I4J|rcsb pdb:6I4K|rcsb pdb:6I4L|rcsb pdb:6I4M|reactome:R-MMU-264870|reactome:R-MMU-6798695|dip:DIP-31941N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:vByKB6qbsPzebkkufeXoP6n0SUI10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q03391	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2309422|uniprotkb:C9K0Z5|ensembl:ENSMUSP00000002848|ensembl:ENSMUSP00000147663	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:nmde4_mouse(display_long)|uniprotkb:Grin2d(gene name)|psi-mi:Grin2d(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2D(gene name synonym)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-4(gene name synonym)|uniprotkb:GluN2D(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:XP_011249107.1|refseq:NP_032198.2|ensembl:ENSMUSG00000002771(gene)|ensembl:ENSMUST00000002848(transcript)|ensembl:ENSMUST00000211713(transcript)|go:"GO:0001964"(startle response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0045202"(synapse)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:Q03391|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:SJwi1VKUdtgh3l6xcUxHm/57loU10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q01097	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-400125|uniprotkb:Q9DCB2	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P35436	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-400115|ensembl:ENSMUSP00000032331|ensembl:ENSMUSP00000111501|ensembl:ENSMUSP00000142900	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:nmde1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:Grin2a(gene name)|psi-mi:Grin2a(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_032196.2|reactome:R-MMU-8849932|reactome:R-MMU-9609736|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-438066|go:"GO:0098839"(postsynaptic density membrane)|ensembl:ENSMUSG00000059003(gene)|ensembl:ENSMUST00000032331(transcript)|ensembl:ENSMUST00000115835(transcript)|ensembl:ENSMUST00000199708(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040011"(locomotion)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|refseq:XP_006521857.1|dip:DIP-31567N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:5DMFDOh6NuFArDtKp2gp2IpmhWQ10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P35438	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q9Z2W9	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-445507|uniprotkb:A2VDF4|uniprotkb:Q5DTJ0|ensembl:ENSMUSP00000075687	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:gria3_mouse(display_long)|uniprotkb:GluR-K3(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 3(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 3(gene name synonym)|uniprotkb:Gria3(gene name)|psi-mi:Gria3(display_short)|uniprotkb:Kiaa4184(gene name synonym)|uniprotkb:Glur3(gene name synonym)|uniprotkb:GluR-C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_058582.3|refseq:XP_006541583.1|refseq:NP_001268858.1|refseq:XP_017174034.1|ensembl:ENSMUSG00000001986(gene)|ensembl:ENSMUST00000076349(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032991"(protein-containing complex)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|go:"GO:0038023"(signaling receptor activity)|interpro:IPR028082|go:"GO:0043025"(neuronal cell body)|mint:Q9Z2W9|rcsb pdb:3LSW|rcsb pdb:3LSX|go:"GO:0043083"(synaptic cleft)|reactome:R-MMU-399710|reactome:R-MMU-399719|reactome:R-MMU-416993|go:"GO:0043195"(terminal bouton)|reactome:R-MMU-438066|go:"GO:0043197"(dendritic spine)|reactome:R-MMU-8849932|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:n9Lnq/kl4co4Th5d/N5JX+cN4yU10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P23819	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-77538|uniprotkb:Q61604|uniprotkb:Q61605|uniprotkb:Q8BG69|uniprotkb:Q8BXU3|uniprotkb:Q9D6D3	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:gria2_mouse(display_long)|uniprotkb:Gria2(gene name)|psi-mi:Gria2(display_short)|uniprotkb:Glur2(gene name synonym)|uniprotkb:GluR-B(gene name synonym)|uniprotkb:GluR-K2(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 2(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051117"(ATPase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|reactome:R-MMU-399710|reactome:R-MMU-416993|reactome:R-MMU-438066|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR028082|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|mint:P23819	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:v71xzThz9kadLOPBasVAc1y/FXs10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P68040	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-296749|ensembl:ENSMUSP00000020640|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-1183965|uniprotkb:Q3THP0|uniprotkb:Q3THY7|uniprotkb:Q3TKQ0|uniprotkb:Q3TW88|uniprotkb:Q5NCC5|uniprotkb:Q5NCC6|uniprotkb:Q9CSQ0|uniprotkb:Q9ERM6	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:rack1_mouse(display_long)|uniprotkb:p205(gene name synonym)|uniprotkb:Receptor of activated protein kinase C 1(gene name synonym)|uniprotkb:12-3(gene name synonym)|uniprotkb:Gnb2-rs1(gene name synonym)|uniprotkb:Gnb2l1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Rack1(gene name)|psi-mi:Rack1(display_short)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P68040|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|go:"GO:0072344"(rescue of stalled ribosome)|ensembl:ENSMUSG00000020372(gene)|ensembl:ENSMUST00000020640(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008104"(protein localization)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0006412"(translation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044297"(cell body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|refseq:NP_032169.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P62880	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-356951|uniprotkb:P11016|uniprotkb:P54312|ensembl:ENSMUSP00000031726|ensembl:ENSMUSP00000129353	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:gbb2_mouse(display_long)|uniprotkb:Gnb2(gene name)|psi-mi:Gnb2(display_short)|uniprotkb:Transducin beta chain 2(gene name synonym)|uniprotkb:G protein subunit beta-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_034442.1|refseq:XP_006504616.1|ensembl:ENSMUSG00000029713(gene)|ensembl:ENSMUST00000031726(transcript)|ensembl:ENSMUST00000150063(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043209"(myelin sheath)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051020"(GTPase binding)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62880|reactome:R-MMU-1296041|reactome:R-MMU-202040|reactome:R-MMU-381676|reactome:R-MMU-392170|reactome:R-MMU-392451|reactome:R-MMU-392851|reactome:R-MMU-400042|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418217|reactome:R-MMU-418555|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418597|reactome:R-MMU-420092|reactome:R-MMU-428930|reactome:R-MMU-432040|reactome:R-MMU-456926|reactome:R-MMU-500657|reactome:R-MMU-6814122|reactome:R-MMU-8964315|reactome:R-MMU-8964616|reactome:R-MMU-9009391|reactome:R-MMU-997272	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:dingPUxdpAhe7UMLquv0eqXNtUM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P62874	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-357152|ensembl:ENSMUSP00000030940|ensembl:ENSMUSP00000101241|ensembl:ENSMUSP00000130123|ensembl:ENSMUSP00000135091|uniprotkb:P04901|uniprotkb:P04697	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:gbb1_mouse(display_long)|uniprotkb:Gnb1(gene name)|psi-mi:Gnb1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000029064(gene)|ensembl:ENSMUST00000030940(transcript)|ensembl:ENSMUST00000105616(transcript)|ensembl:ENSMUST00000165335(transcript)|ensembl:ENSMUST00000176637(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007603"(phototransduction, visible light)|reactome:R-MMU-9009391|reactome:R-MMU-997272|reactome:R-MMU-8964616|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030425"(dendrite)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043209"(myelin sheath)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62874|rcsb pdb:6K41|rcsb pdb:6K42|rcsb pdb:6RMV|reactome:R-MMU-1296041|reactome:R-MMU-202040|reactome:R-MMU-2485179|reactome:R-MMU-381676|reactome:R-MMU-381753|reactome:R-MMU-392170|reactome:R-MMU-392451|reactome:R-MMU-392851|reactome:R-MMU-400042|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418217|reactome:R-MMU-418555|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418597|reactome:R-MMU-420092|reactome:R-MMU-428930|reactome:R-MMU-432040|reactome:R-MMU-456926|reactome:R-MMU-500657|reactome:R-MMU-6814122|reactome:R-MMU-8964315|refseq:NP_001153488.1|refseq:NP_001153489.1|refseq:NP_032168.1|refseq:XP_017175466.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:zP/G70MXiSQpzbyyWFTWrJFQENk10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:P15105	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-444858|uniprotkb:Q3TRK7|uniprotkb:Q64432|uniprotkb:Q91VC6|ensembl:ENSMUSP00000083375|ensembl:ENSMUSP00000123157	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:glna_mouse(display_long)|uniprotkb:Glutamate--ammonia ligase(gene name synonym)|uniprotkb:Glul(gene name)|psi-mi:Glul(display_short)|uniprotkb:Glns(gene name synonym)|uniprotkb:Palmitoyltransferase GLUL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_032157.2|go:"GO:0030145"(manganese ion binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0097386"(glial cell projection)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR008146(Glutamine synthetase, catalytic region)|interpro:IPR008147(Glutamine synthetase, beta-Grasp)|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR027302|interpro:IPR027303|interpro:IPR036651|mint:P15105|reactome:R-MMU-210455|reactome:R-MMU-8964539|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|ensembl:ENSMUSG00000026473(gene)|ensembl:ENSMUST00000086199(transcript)|ensembl:ENSMUST00000140685(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0004356"(glutamate-ammonia ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006542"(glutamine biosynthetic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0016595"(glutamate binding)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019676"(ammonia assimilation cycle)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:j6R9fxGLKpiREWpecpdnBY9ftoo10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q68FF6	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-645933|ensembl:ENSMUSP00000037210	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q61598	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-6665490|ensembl:ENSMUSP00000152454|uniprotkb:Q541Z9|uniprotkb:Q8C530|uniprotkb:Q9D8M9	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:gdib_mouse(display_long)|uniprotkb:Gdi2(gene name)|psi-mi:Gdi2(display_short)|uniprotkb:Gdi3(gene name synonym)|uniprotkb:GDI-3(gene name synonym)|uniprotkb:Guanosine diphosphate dissociation inhibitor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:Q61598|reactome:R-MMU-6798695|reactome:R-MMU-8876198|ensembl:ENSMUSG00000021218(gene)|ensembl:ENSMUST00000223396(transcript)|refseq:NP_032138.3|dip:DIP-348N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:+ngZz9q02lDEdFO543w/yl6chgc10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q6NS60	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-16725383|ensembl:ENSMUSP00000124524|ensembl:ENSMUSP00000124754|ensembl:ENSMUSP00000125671|uniprotkb:Q6P7W4|uniprotkb:Q6ZPG1	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:fbx41_mouse(display_long)|uniprotkb:Fbxo41(gene name)|psi-mi:Fbxo41(display_short)|uniprotkb:D6Ertd538e(gene name synonym)|uniprotkb:Kiaa1940(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	ensembl:ENSMUSG00000047013(gene)|ensembl:ENSMUST00000159062(transcript)|ensembl:ENSMUST00000161078(transcript)|ensembl:ENSMUST00000161546(transcript)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-MMU-8951664|reactome:R-MMU-983168|refseq:NP_001001160.1|refseq:NP_001276603.1|refseq:NP_001276604.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:MbpGArQonCm6vp3gakR01/4W5Fg10090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9D415	uniprotkb:Q80UW2	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	intact:EBI-2314714|uniprotkb:Q8R0D2|ensembl:ENSMUSP00000037377	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:fbx2_mouse(display_long)|uniprotkb:Fbs1(gene name synonym)|uniprotkb:Fbxo2(gene name)|psi-mi:Fbxo2(display_short)|uniprotkb:Fbx2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16725590|imex:IM-26285-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	refseq:NP_789818.1|refseq:XP_006538877.1|dip:DIP-54758N|ensembl:ENSMUSG00000041556(gene)|ensembl:ENSMUST00000047951(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0043197"(dendritic spine)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR007397(F-box associated region)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036047|interpro:IPR039752|rcsb pdb:1UMH|rcsb pdb:1UMI|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2E33|rcsb pdb:2RJ2|rcsb pdb:5B4N|reactome:R-MMU-8951664|reactome:R-MMU-983168	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2019/02/20	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rogid:MFGKJfNmB58nx1Ij634RZe95br010090	rigid:849wLYq9iFKvV5weLzMRWSfDxAE	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8CFI0	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-8046183|uniprotkb:Q8BS42|uniprotkb:Q8BRT9|intact:MINT-5097552|uniprotkb:Q99PK2	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ned4l_mouse(display_long)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:Nedd4l(gene name)|psi-mi:Nedd4l(display_short)|uniprotkb:Kiaa0439(gene name synonym)|uniprotkb:Nedd4b(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	dip:DIP-48843N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0009651"(response to salt stress)|go:"GO:0010038"(response to metal ion)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:1WR3|rcsb pdb:1WR4|rcsb pdb:1WR7|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-MMU-2173795|reactome:R-MMU-2672351|reactome:R-MMU-983168	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:rne2aA4b/xoATCErEBuu9uK3Zxk10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q810U4	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-8321816|uniprotkb:Q8BLG8|uniprotkb:Q8BX92|intact:MINT-3090404|uniprotkb:Q8BYJ8|uniprotkb:Q80U33|ensembl:ENSMUSP00000020939	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:nrcam_mouse(display_long)|uniprotkb:Nrcam(gene name)|psi-mi:Nrcam(display_short)|uniprotkb:Kiaa0343(gene name synonym)|uniprotkb:NgCAM-related cell adhesion molecule(gene name synonym)|uniprotkb:Neuronal surface protein Bravo(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_795904.3|refseq:NP_001139503.1|ensembl:ENSMUSG00000020598(gene)|ensembl:ENSMUST00000020939(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0008104"(protein localization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0033268"(node of Ranvier)|go:"GO:0043194"(axon initial segment)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0045202"(synapse)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099175"(regulation of postsynapse organization)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026966|interpro:IPR036116|interpro:IPR036179|interpro:IPR043204|mint:Q810U4	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:Q2DED8Rhe2F3bHYkEbvfKEa2ing10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q923D5	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-8339190|uniprotkb:O88539|uniprotkb:Q8VDI0|uniprotkb:Q3UMD8|intact:MINT-125895|ensembl:ENSMUSP00000112213	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:wbp11_mouse(display_long)|uniprotkb:Wbp11(gene name)|psi-mi:Wbp11(display_short)|uniprotkb:Sipp1(gene name synonym)|uniprotkb:Splicing factor that interacts with PQBP-1 and PP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_068360.4|refseq:XP_017177182.1|ensembl:ENSMUSG00000030216(gene)|ensembl:ENSMUST00000116514(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0050699"(WW domain binding)|interpro:IPR019007|mint:Q923D5|reactome:R-MMU-72163	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:May play a role in the regulation of pre-mRNA processing	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:YCcyxBraQLnCIceR99oIZ6pAyXQ10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q80YT5	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-7990667|intact:UNK-5501527|ensembl:ENSMUSP00000042572	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:spt20_mouse(display_long)|uniprotkb:Spata20(gene name)|psi-mi:Spata20(display_short)|uniprotkb:Tisp78(gene name synonym)|uniprotkb:Transcript increased in spermiogenesis 78 protein(gene name synonym)|uniprotkb:Sperm-specific protein 411(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_659076.2|ensembl:ENSMUSG00000020867(gene)|ensembl:ENSMUST00000041705(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|interpro:IPR004879(Protein of unknown function DUF255)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR012341(Six-hairpin glycosidase)|interpro:IPR024705|interpro:IPR036249	go:"GO:0014069"(postsynaptic density)	-	function:May play a role in fertility regulation|comment:mint	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:O8BITvutVTFM6QfqLgDzUGs3FTk10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:A2AAY5	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-8412723|uniprotkb:Q3TB89|uniprotkb:Q8BIC6|intact:MINT-4110712|uniprotkb:B6F0V1|uniprotkb:Q1LZM5|uniprotkb:Q1LZL8|ensembl:ENSMUSP00000044276	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:spd2b_mouse(display_long)|uniprotkb:Sh3pxd2b(gene name)|psi-mi:Sh3pxd2b(display_short)|uniprotkb:Tks4(gene name synonym)|uniprotkb:Fad49(gene name synonym)|uniprotkb:Factor for adipocyte differentiation 49(gene name synonym)|uniprotkb:Tyrosine kinase substrate with four SH3 domains(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_796338.2|ensembl:ENSMUSG00000040711(gene)|ensembl:ENSMUST00000038753(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001654"(eye development)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030054"(cell junction)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042995"(cell projection)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060348"(bone development)|go:"GO:0060378"(regulation of brood size)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071800"(podosome assembly)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1904888"(cranial skeletal system development)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030512|interpro:IPR035477|interpro:IPR035478|interpro:IPR035479|interpro:IPR035480|interpro:IPR036028|interpro:IPR036871|interpro:IPR037961|mint:A2AAY5|go:"GO:0060090"(molecular adaptor activity)	go:"GO:0014069"(postsynaptic density)	-	function:"Binds phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2)"|comment:mint	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:TFz2wjgH548+QpkHqH83EhLelZ010090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q91XU3	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-8418084|uniprotkb:Q99K02|uniprotkb:Q3UFU5|intact:MINT-4121758|ensembl:ENSMUSP00000013970	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:pi42c_mouse(display_long)|uniprotkb:Phosphatidylinositol 5-phosphate 4-kinase type II gamma(gene name synonym)|uniprotkb:Pip4k2c(gene name)|psi-mi:Pip4k2c(display_short)|uniprotkb:Pip5k2c(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_473438.1|refseq:XP_017169257.1|ensembl:ENSMUSG00000025417(gene)|ensembl:ENSMUST00000013970(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0016309"(1-phosphatidylinositol-5-phosphate 4-kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0090217"(negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:1902635"(1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|mint:Q91XU3|reactome:R-MMU-1660499|reactome:R-MMU-6811555|reactome:R-MMU-6811558|reactome:R-MMU-8847453	go:"GO:0014069"(postsynaptic density)	-	function:"May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum"|comment:mint	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:zBeOjcUhFT6OO19aYaI8AVqWFgw10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q6P9L6	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-8586561|ensembl:ENSMUSP00000035490|uniprotkb:Q70MX5|uniprotkb:O35065|intact:UNK-5482037	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:kif15_mouse(display_long)|uniprotkb:Klp2(gene name synonym)|uniprotkb:Knsl7(gene name synonym)|uniprotkb:Kinesin-like protein 2(gene name synonym)|uniprotkb:Kinesin-like protein 7(gene name synonym)|uniprotkb:Kif15(gene name)|psi-mi:Kif15(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000036768(gene)|ensembl:ENSMUST00000040717(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR031794|interpro:IPR036961|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189|refseq:NP_034750.1	go:"GO:0014069"(postsynaptic density)	-	comment:mint	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:apHySN9WwHHX9Qh/HQGQbfPA22E10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q61584	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P83510	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-7280013|intact:MINT-4138101|ensembl:ENSMUSP00000124681	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:tnik_mouse(display_long)|uniprotkb:Tnik(gene name)|psi-mi:Tnik(display_short)|uniprotkb:Kiaa0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001156480.1|ensembl:ENSMUSG00000027692(gene)|ensembl:ENSMUST00000159236(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P83510|reactome:R-MMU-2559580|go:"GO:0055037"(recycling endosome)|dip:DIP-57467N	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:+Hdc1nFS32RS9/n1kdeF66gw2zs10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:O54988	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-8314190|ensembl:ENSMUSP00000049977|uniprotkb:Q8CAU2|uniprotkb:A2RRK4|uniprotkb:Q80U65|uniprotkb:Q8CDW2|intact:MINT-4105110|uniprotkb:Q9WU41	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:slk_mouse(display_long)|uniprotkb:Slk(gene name)|psi-mi:Slk(display_short)|uniprotkb:Kiaa0204(gene name synonym)|uniprotkb:Stk2(gene name synonym)|uniprotkb:STE20-related serine/threonine-protein kinase(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 2(gene name synonym)|uniprotkb:STE20-related kinase SMAK(gene name synonym)|uniprotkb:Etk4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000025060(gene)|ensembl:ENSMUST00000051691(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022165|mint:O54988|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001943(UvrB/UvrC protein)|refseq:NP_033315.2|refseq:NP_001158111.1	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:Mediates apoptosis and actin stress fiber dissolution	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:TG8n5uo72LrZ6Gf6oyJKvtviYyk10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9WUT3	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-7837634|ensembl:ENSMUSP00000024575|intact:MINT-1486826|uniprotkb:Q9D2C0	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ks6a2_mouse(display_long)|uniprotkb:Rps6ka2(gene name)|psi-mi:Rps6ka2(display_short)|uniprotkb:Rsk3(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 2(gene name synonym)|uniprotkb:Ribosomal S6 kinase 3(gene name synonym)|uniprotkb:pp90RSK3(gene name synonym)|uniprotkb:Protein-tyrosine kinase Mpk-9(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1c(gene name synonym)|uniprotkb:Mapkapk1c(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000023809(gene)|ensembl:ENSMUST00000024575(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001556"(oocyte maturation)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0060047"(heart contraction)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0072687"(meiotic spindle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR041906|interpro:IPR042766|reactome:R-MMU-198753|reactome:R-MMU-199920|reactome:R-MMU-2559582|reactome:R-MMU-442742|reactome:R-MMU-444257|reactome:R-MMU-881907|refseq:NP_035429.1	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:vwP4hJ931kpHykwYsHrGnYOhndc10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8CHG7	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-7027510|ensembl:ENSMUSP00000114119|intact:MINT-4133098|uniprotkb:E9QMD0	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:rpgf2_mouse(display_long)|uniprotkb:Rapgef2(gene name)|psi-mi:Rapgef2(display_short)|uniprotkb:Kiaa0313(gene name synonym)|uniprotkb:Pdzgef1(gene name synonym)|uniprotkb:Neural RAP guanine nucleotide exchange protein(gene name synonym)|uniprotkb:PDZ domain-containing guanine nucleotide exchange factor 1(gene name synonym)|uniprotkb:Cyclic nucleotide ras GEF(gene name synonym)|uniprotkb:RA-GEF-1(gene name synonym)|uniprotkb:Ras/Rap1-associating GEF-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:XP_006502317.1|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|go:"GO:0050699"(WW domain binding)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000159(Ras-association)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR018490|interpro:IPR023578|interpro:IPR029071|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030739|interpro:IPR036034|mint:Q8CHG7|reactome:R-MMU-5673001|ensembl:ENSMUSG00000062232(gene)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021591"(ventricular system development)|go:"GO:0021884"(forebrain neuron development)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038180"(nerve growth factor signaling pathway)|ensembl:ENSMUST00000118100(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001764"(neuron migration)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045202"(synapse)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048022"(negative regulation of melanin biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)	go:"GO:0014069"(postsynaptic density)	-	comment:"fragmentation type: fragment"|comment:mint|comment:homomint|function:"Guanine nucleotide exchange factor (GEF) for Rap1, Rap1B and Rap2 GTPases"	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:gH1WVMkcR44bJMCVvh7NctDb5KI10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P20444	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-6976815|intact:MINT-98140	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:kpca_mouse(display_long)|uniprotkb:Prkca(gene name)|psi-mi:Prkca(display_short)|uniprotkb:Pkca(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001525"(angiogenesis)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002159"(desmosome assembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007611"(learning or memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000707"(positive regulation of dense core granule biogenesis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034663|interpro:IPR035892|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-1250196|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-2179392|reactome:R-MMU-3000170|reactome:R-MMU-399997|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-450520|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|reactome:R-MMU-8853659|refseq:NP_035231.2|mint:P20444|dip:DIP-532N	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. May play a role in cell motility by phosphorylating CSPG4|function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters|function:Expression of the mutant form UV25 causes malignant transformation of cells	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:mcB2Fkcsk/5w7OhEH93JAec585I10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q7TN74	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-7385297|intact:MINT-4600266|ensembl:ENSMUSP00000046906	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:q7tn74_mouse(display_long)|uniprotkb:Ppp1r9a(gene name)|psi-mi:Ppp1r9a(display_short)|uniprotkb:Neurabin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_853626.1|ensembl:ENSMUSG00000032827(gene)|ensembl:ENSMUST00000035813(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|refseq:XP_006505142.1|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1990761"(growth cone lamellipodium)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR029994|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q7TN74|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)	go:"GO:0014069"(postsynaptic density)	-	comment:mint	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:Wxg3Z5Mlh48qmQ+FMbR/MqquP7k10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q3UM45	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-8318179|ensembl:ENSMUSP00000027494|intact:MINT-1869744|uniprotkb:Q9CV31|uniprotkb:Q9Z105|intact:MINT-3292766	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:pp1r7_mouse(display_long)|uniprotkb:Ppp1r7(gene name)|psi-mi:Ppp1r7(display_short)|uniprotkb:Sds22(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 22(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000026275(gene)|ensembl:ENSMUST00000027494(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0007059"(chromosome segregation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR025875|interpro:IPR032675|mint:Q3UM45|refseq:NP_075689.1	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:Regulatory subunit of protein phosphatase 1	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:/Mhy2MmXvmdOYuIKhxmu/rNQRKc10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9QXB9	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-8585956|ensembl:ENSMUSP00000018568|intact:MINT-4619155|uniprotkb:Q5SX94	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:drg2_mouse(display_long)|uniprotkb:Drg2(gene name)|psi-mi:Drg2(display_short)|uniprotkb:Translation factor GTPase DRG2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000020537(gene)|ensembl:ENSMUST00000018568(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR004095(TGS)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR006074(GTP1/OBG, conserved site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR027417|interpro:IPR031167|interpro:IPR031662|refseq:NP_067329.1	go:"GO:0014069"(postsynaptic density)	-	comment:mint|function:May play a role in cell proliferation, differentiation and death	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:3k9KBJVWLVXzD/iHmjwM6vfLFEU10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P46935	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q14BI2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-5281533|ensembl:ENSMUSP00000023959	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:grm2_mouse(display_long)|uniprotkb:Grm2(gene name)|psi-mi:Grm2(display_short)|uniprotkb:Gprc1b(gene name synonym)|uniprotkb:Mglur2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001153825.1|ensembl:ENSMUSG00000023192(gene)|ensembl:ENSMUST00000023959(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:Q14BI2|reactome:R-MMU-418594|reactome:R-MMU-420499	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:51Vq4ZsTylhat6thFK/8MBMIKUI10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q7TT50	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-771662|uniprotkb:E9QK15|uniprotkb:Q69ZR5|uniprotkb:Q80W33|ensembl:ENSMUSP00000042565	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:mrckb_mouse(display_long)|uniprotkb:CDC42-binding protein kinase beta(gene name synonym)|uniprotkb:Myotonic dystrophy kinase-related CDC42-binding kinase beta(gene name synonym)|uniprotkb:DMPK-like beta(gene name synonym)|uniprotkb:Cdc42bpb(gene name)|psi-mi:Cdc42bpb(display_short)|uniprotkb:Kiaa1124(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_898837.2|ensembl:ENSMUSG00000021279(gene)|ensembl:ENSMUST00000041965(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042641"(actomyosin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014930(DMPK coiled coil)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR031597|interpro:IPR033232|interpro:IPR042718|reactome:R-MMU-9013148|reactome:R-MMU-9013406	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:gXGKo/AZU7Vr8NERSStovYdzcuw10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q149C2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726521|ensembl:ENSMUSP00000042391|uniprotkb:Q538H5|uniprotkb:Q80VQ3|uniprotkb:Q9CS98	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:mipt3_mouse(display_long)|uniprotkb:Intraflagellar transport protein 54 homolog(gene name synonym)|uniprotkb:Microtubule-interacting protein associated with TRAF3(gene name synonym)|uniprotkb:Traf3ip1(gene name)|psi-mi:Traf3ip1(display_short)|uniprotkb:Ift54(gene name synonym)|uniprotkb:Mipt3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000034292(gene)|ensembl:ENSMUST00000047242(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001822"(kidney development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0021532"(neural tube patterning)|go:"GO:0030992"(intraciliary transport particle B)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|interpro:IPR018799|interpro:IPR040468|interpro:IPR041476|interpro:IPR042576|rcsb pdb:5FMU|reactome:R-MMU-5620924|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|refseq:NP_082994.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:MykwZRj/gtQR0ghgq2xiIoh42y410090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P05480	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-298680|ensembl:ENSMUSP00000029175|ensembl:ENSMUSP00000105157|ensembl:ENSMUSP00000105159|uniprotkb:Q2M4I4|intact:EBI-7361449|intact:MINT-142018|uniprotkb:F8WI90	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:src_mouse(display_long)|uniprotkb:Src(gene name)|psi-mi:Src(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P05480|rcsb pdb:6F3F|reactome:R-MMU-1227986|reactome:R-MMU-1251985|reactome:R-MMU-1253288|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-177929|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-191650|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418885|reactome:R-MMU-430116|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-456926|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-6811558|reactome:R-MMU-69231|reactome:R-MMU-8853659|reactome:R-MMU-8874081|reactome:R-MMU-8934903|reactome:R-MMU-8941858|reactome:R-MMU-9009391|reactome:R-MMU-9603381|ensembl:ENSMUSG00000027646(gene)|ensembl:ENSMUST00000029175(transcript)|ensembl:ENSMUST00000109531(transcript)|ensembl:ENSMUST00000109533(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|refseq:NP_001020566.1|refseq:NP_033297.2|dip:DIP-31071N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:SY8bQUpE/ni7hRMp4F02ygRsU7Q10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P62835	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-1634972|uniprotkb:P10113|ensembl:ENSMUSP00000088174	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:rap1a_mouse(display_long)|uniprotkb:Rap1a(gene name)|psi-mi:Rap1a(display_short)|uniprotkb:Krev-1(gene name synonym)|uniprotkb:Ras-related protein Krev-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_663516.1|refseq:XP_006500970.1|ensembl:ENSMUSG00000068798(gene)|ensembl:ENSMUST00000090678(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0030054"(cell junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0035690"|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:0097421"(liver regeneration)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|mint:P62835|reactome:R-MMU-170968|reactome:R-MMU-170984|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-5674135|reactome:R-MMU-6798695|reactome:R-MMU-8875555	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:QtjMjJiMQF0CbTD40IZgca4XfIU10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P48453	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-642618|uniprotkb:Q6NZR4|ensembl:ENSMUSP00000125722	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:pp2bb_mouse(display_long)|uniprotkb:Calmodulin-dependent calcineurin A subunit beta isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Ppp3cb(gene name)|psi-mi:Ppp3cb(display_short)|uniprotkb:Calnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_032940.1|refseq:NP_001297355.1|refseq:NP_001297356.1|ensembl:ENSMUSG00000021816(gene)|ensembl:ENSMUST00000159027(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P48453|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|go:"GO:0005516"(calmodulin binding)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:YD7q3dcL87htgwHRd5m5ReMlqd010090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q63844	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-397682|uniprotkb:Q61531|uniprotkb:Q8K0X5|uniprotkb:Q91YW5|ensembl:ENSMUSP00000051619	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:mk03_mouse(display_long)|uniprotkb:Mapk3(gene name)|psi-mi:Mapk3(display_short)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:MNK1(gene name synonym)|uniprotkb:Erk1(gene name synonym)|uniprotkb:Prkm3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_036082.1|dip:DIP-31078N|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0014032"(neural crest cell development)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|ensembl:ENSMUSG00000063065(gene)|ensembl:ENSMUST00000057669(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|reactome:R-MMU-9627069|reactome:R-MMU-982772|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63844|reactome:R-MMU-110056|reactome:R-MMU-112409|reactome:R-MMU-1169408|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6811558|reactome:R-MMU-73728|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:I2hStA4IjS6t6Ky7fb9zFPOcZag10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P63085	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P47809	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-447934|ensembl:ENSMUSP00000041282	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:mp2k4_mouse(display_long)|uniprotkb:MAPK/ERK kinase 4(gene name synonym)|uniprotkb:JNK-activating kinase 1(gene name synonym)|uniprotkb:C-JUN N-terminal kinase kinase 1(gene name synonym)|uniprotkb:SAPK/ERK kinase 1(gene name synonym)|uniprotkb:Map2k4(gene name)|psi-mi:Map2k4(display_short)|uniprotkb:Jnkk1(gene name synonym)|uniprotkb:Prkmk4(gene name synonym)|uniprotkb:Sek1(gene name synonym)|uniprotkb:Serk1(gene name synonym)|uniprotkb:Skk1(gene name synonym)|uniprotkb:Mkk4(gene name synonym)|uniprotkb:Mek4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_033183.1|dip:DIP-869N|ensembl:ENSMUSG00000033352(gene)|ensembl:ENSMUST00000046963(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009611"(response to wounding)|go:"GO:0030424"(axon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P47809|reactome:R-MMU-2559580|reactome:R-MMU-2871796|reactome:R-MMU-450321	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:6v5etIlqj4yLuTNnVlEBVRaMYKg10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9QXL2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-911098|uniprotkb:Q6P5H1|uniprotkb:Q6ZPJ8|uniprotkb:Q8BWZ9|uniprotkb:Q8BXF1|ensembl:ENSMUSP00000085985	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ki21a_mouse(display_long)|uniprotkb:Kif21a(gene name)|psi-mi:Kif21a(display_short)|uniprotkb:Kiaa1708(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001102510.1|refseq:NP_001102511.1|refseq:NP_001102512.1|refseq:NP_057914.2|ensembl:ENSMUSG00000022629(gene)|ensembl:ENSMUST00000088614(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:1990939"|interpro:IPR001680(WD40 repeat)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036322|interpro:IPR036961|mint:Q9QXL2|rcsb pdb:5YAY|rcsb pdb:5YBE|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:PQNGrSKw7f5ThMhMs/glF32RiZs10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q3UVX5	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-8795045|ensembl:ENSMUSP00000114927	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:grm5_mouse(display_long)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|reactome:R-MMU-416476|reactome:R-MMU-420499|reactome:R-MMU-6794361|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|ensembl:ENSMUSG00000049583(gene)|ensembl:ENSMUST00000155358(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|refseq:XP_011239945.1|refseq:NP_001137306.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:pA3IUBq9r3mGn7M8R2qnAaYqaT810090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q60737	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-771698|uniprotkb:Q8R0X4|ensembl:ENSMUSP00000096829	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:csk21_mouse(display_long)|uniprotkb:Csnk2a1(gene name)|psi-mi:Csnk2a1(display_short)|uniprotkb:Ckiia(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_031814.2|refseq:XP_011237574.1|refseq:XP_006498720.1|dip:DIP-32409N|ensembl:ENSMUSG00000074698(gene)|ensembl:ENSMUST00000099224(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q60737|reactome:R-MMU-1483191|reactome:R-MMU-201688|reactome:R-MMU-2514853|reactome:R-MMU-445144|reactome:R-MMU-6804756|reactome:R-MMU-6814122|reactome:R-MMU-8934903|reactome:R-MMU-8939243|reactome:R-MMU-8948751	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:7UK+lLG3t/3xJi7CaiGSCIcxfPg10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q99PP2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726499|ensembl:ENSMUSP00000109109|uniprotkb:Q3TZL5|uniprotkb:Q8BMX9|uniprotkb:Q9JJ01|uniprotkb:B0V2M3|uniprotkb:B9EK88	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:zn318_mouse(display_long)|uniprotkb:Testicular zinc finger protein(gene name synonym)|uniprotkb:Znf318(gene name)|psi-mi:Znf318(display_short)|uniprotkb:Tzf(gene name synonym)|uniprotkb:Zfp318(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000015597(gene)|ensembl:ENSMUST00000113481(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR003604(Zinc finger, U1-type)|mint:Q99PP2|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042803"(protein homodimerization activity)|refseq:NP_997554.2|refseq:NP_067321.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:YlyBt2UNh34DlqoslOr6yKf8tc410090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8CF60	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726479|ensembl:ENSMUSP00000023176|uniprotkb:E9PXW0|uniprotkb:Q7TMI6|uniprotkb:Q8K439	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:zn263_mouse(display_long)|uniprotkb:Znf263(gene name)|psi-mi:Znf263(display_short)|uniprotkb:FPM315(gene name synonym)|uniprotkb:ZKSCAN12(gene name synonym)|uniprotkb:Zfp263(gene name synonym)|uniprotkb:Zinc finger protein FPM315(gene name synonym)|uniprotkb:Zinc finger protein with KRAB and SCAN domains 12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000022529(gene)|ensembl:ENSMUST00000023176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030752|interpro:IPR036051|interpro:IPR036236|interpro:IPR038269|reactome:R-MMU-212436|refseq:NP_683726.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:psPERDxBYR4ymhFeKtm03GkxOzg10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8BH43	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q62318	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-346909|uniprotkb:P70391|uniprotkb:Q8C283|uniprotkb:Q99PN4|ensembl:ENSMUSP00000005705	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:tif1b_mouse(display_long)|uniprotkb:Trim28(gene name)|psi-mi:Trim28(display_short)|uniprotkb:Krip1(gene name synonym)|uniprotkb:Tif1b(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:KRAB-A-interacting protein(gene name synonym)|uniprotkb:KRIP-1(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:Kap1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_035718.2|dip:DIP-31477N|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q62318|rcsb pdb:6O5K|reactome:R-MMU-212436|ensembl:ENSMUSG00000005566(gene)|ensembl:ENSMUST00000005705(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:DvGJxQNohVWs++QEAyrqe4ngcz810090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q5DU57	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726449|uniprotkb:Q3TZ09	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:spt13_mouse(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:Spata13(gene name)|psi-mi:Spata13(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046847"(filopodium assembly)|reactome:R-MMU-9013149|reactome:R-MMU-9013148|refseq:NP_001028444.1|refseq:NP_001297523.1|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR036028|interpro:IPR001452(Src homology-3)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:bv1eL5RAkdw2LYvmRRRWxO6uZ5810090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q6NZL0	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-776265|uniprotkb:Q8BLM2|uniprotkb:Q9CSN3|uniprotkb:Q9CU45|ensembl:ENSMUSP00000090293	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:soga3_mouse(display_long)|uniprotkb:Soga3(gene name)|psi-mi:Soga3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_080414.2|ensembl:ENSMUSG00000038916(gene)|ensembl:ENSMUST00000092629(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|interpro:IPR027881	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:fqFLavYLqmaqDCGT+/GaB6l9h9U10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P70423	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726414|ensembl:ENSMUSP00000073582|ensembl:ENSMUSP00000098914|ensembl:ENSMUSP00000109339|uniprotkb:B1AVE2	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ctr3_mouse(display_long)|uniprotkb:Cationic amino acid transporter y+(gene name synonym)|uniprotkb:Solute carrier family 7 member 3(gene name synonym)|uniprotkb:Slc7a3(gene name)|psi-mi:Slc7a3(display_short)|uniprotkb:Atrc3(gene name synonym)|uniprotkb:Cat3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUST00000073927(transcript)|ensembl:ENSMUST00000101362(transcript)|ensembl:ENSMUST00000113710(transcript)|go:"GO:0000064"(L-ornithine transmembrane transporter activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015174"(basic amino acid transmembrane transporter activity)|go:"GO:0015181"|go:"GO:0015189"(L-lysine transmembrane transporter activity)|go:"GO:0015809"|go:"GO:0015819"(lysine transport)|go:"GO:0015822"(ornithine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0097638"(L-arginine import across plasma membrane)|go:"GO:0097639"(L-lysine import across plasma membrane)|go:"GO:0097640"(L-ornithine import across plasma membrane)|go:"GO:1903352"(L-ornithine transmembrane transport)|interpro:IPR002293(Amino acid/polyamine transporter I)|interpro:IPR004755(Cationic amino acid transport permease)|interpro:IPR015606(Cationic amino acid transporter)|interpro:IPR029485|reactome:R-MMU-352230|ensembl:ENSMUSG00000031297(gene)|refseq:NP_001288769.1|refseq:NP_031541.1|refseq:XP_006527816.1|refseq:XP_011245812.1|refseq:XP_011245813.1|refseq:XP_011245814.1|refseq:XP_011245815.1|refseq:XP_017173852.1|refseq:XP_017173853.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:ISTb9/icitiIP4tSB5yIC2XqIEA10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9Z131	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726388|ensembl:ENSMUSP00000117152|uniprotkb:Q3TTD6|uniprotkb:Q8C903|uniprotkb:Q8VCZ0	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:3bp5_mouse(display_long)|uniprotkb:SH3 domain-binding protein that preferentially associates with BTK(gene name synonym)|uniprotkb:Sh3bp5(gene name)|psi-mi:Sh3bp5(display_short)|uniprotkb:Sab(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000021892(gene)|ensembl:ENSMUST00000140002(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|interpro:IPR007940(SH3-binding 5)|refseq:NP_001334514.1|refseq:NP_036024.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:A8dYi3oIDClj1Fb4zgAwoWUFe2Y10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8R3Q2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-4285597|uniprotkb:Q9CXB7	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:pp6r2_mouse(display_long)|uniprotkb:Ppp6r2(gene name)|psi-mi:Ppp6r2(display_short)|uniprotkb:Kiaa0685(gene name synonym)|uniprotkb:Pp6r2(gene name synonym)|uniprotkb:Saps2(gene name synonym)|uniprotkb:SAPS domain family member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	mint:Q8R3Q2|interpro:IPR007587(SIT4 phosphatase-associated protein)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR016024(Armadillo-type fold)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:NKhCFgctjoEdJxqAxzU6GnXg4iQ10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9CQR6	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-4286534|uniprotkb:A2ASL7|ensembl:ENSMUSP00000028087	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ppp6_mouse(display_long)|uniprotkb:Ppp6c(gene name)|psi-mi:Ppp6c(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_077171.1|ensembl:ENSMUSG00000026753(gene)|ensembl:ENSMUST00000028087(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:Q9CQR6|reactome:R-MMU-171319|reactome:R-MMU-204005|go:"GO:0006470"(protein dephosphorylation)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:R0jsZoqJLoRaSNMNCLRkQ40CC+o10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9JJV2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-990247|uniprotkb:Q9ES48|uniprotkb:Q9ES49|uniprotkb:Q9ES50|uniprotkb:Q3TPT7|uniprotkb:Q3V171|ensembl:ENSMUSP00000068890	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:prof2_mouse(display_long)|uniprotkb:Profilin II(gene name synonym)|uniprotkb:Pfn2(gene name)|psi-mi:Pfn2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000027805(gene)|ensembl:ENSMUST00000066882(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:1900028"(negative regulation of ruffle assembly)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|go:"GO:0050821"(protein stabilization)|interpro:IPR027310|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR029891|interpro:IPR036140|mint:Q9JJV2|rcsb pdb:2V8C|go:"GO:0098793"(presynapse)|rcsb pdb:2V8F|reactome:R-MMU-376176|go:"GO:0098794"(postsynapse)|reactome:R-MMU-5663220|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|refseq:NP_062283.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:uNzINp9rOD7Tub8YlybDaVOgLNc10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q80YT7	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726361|uniprotkb:C4IXU1|uniprotkb:Q05CH5|uniprotkb:Q80U00|uniprotkb:Q8K240	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:myome_mouse(display_long)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)|uniprotkb:Kiaa0454(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034622"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1903358"(regulation of Golgi organization)|mint:Q80YT7|refseq:NP_001034465.2|refseq:NP_835181.2|interpro:IPR012943(Spindle associated)|interpro:IPR010630(Protein of unknown function DUF1220)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:zVBkYyVR82H9Xm1vqn3lSkgZ//I10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q04690	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-397326|uniprotkb:Q61956|uniprotkb:Q61957|ensembl:ENSMUSP00000071289	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:nf1_mouse(display_long)|uniprotkb:Nf1(gene name)|psi-mi:Nf1(display_short)|uniprotkb:Neurofibromatosis-related protein NF-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_035027.1|refseq:XP_006532504.1|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0008542"(visual learning)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0021510"(spinal cord development)|go:"GO:0021764"(amygdala development)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0021915"(neural tube development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0045685"(regulation of glial cell differentiation)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023152|interpro:IPR036865|interpro:IPR039360|mint:Q04690|go:"GO:0030424"(axon)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035021"(negative regulation of Rac protein signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045545"(syndecan binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|ensembl:ENSMUSG00000020716(gene)|ensembl:ENSMUST00000071325(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001656"(metanephros development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007154"(cell communication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|reactome:R-MMU-5658442	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:aegHzgNy813/APoCjeM166e+MFE10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q6P5H2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-2899462|ensembl:ENSMUSP00000088493|uniprotkb:A1E2I2|uniprotkb:Q80X00|uniprotkb:Q8BPH7|uniprotkb:Q9CV43|uniprotkb:Q9R0C4	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:nest_mouse(display_long)|uniprotkb:Nes(gene name)|psi-mi:Nes(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUST00000090973(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030844"(positive regulation of intermediate filament depolymerization)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048858"(cell projection morphogenesis)|ensembl:ENSMUSG00000004891(gene)|go:"GO:0072089"(stem cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR018039|interpro:IPR031211|interpro:IPR039008|refseq:NP_057910.3	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:c9UQwTSScUEP6n41WzoQiEzEyN410090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P12025	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726312|ensembl:ENSMUSP00000028672|ensembl:ENSMUSP00000068413|ensembl:ENSMUSP00000088090|ensembl:ENSMUSP00000106941	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:mk_mouse(display_long)|uniprotkb:Retanoic acid-responsive protein(gene name synonym)|uniprotkb:Retinoic acid-induced differentiation factor(gene name synonym)|uniprotkb:Mdk(gene name)|psi-mi:Mdk(display_short)|uniprotkb:Mk(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000027239(gene)|ensembl:ENSMUST00000028672(transcript)|ensembl:ENSMUST00000069423(transcript)|ensembl:ENSMUST00000090602(transcript)|ensembl:ENSMUST00000111309(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007614"(short-term memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016477"(cell migration)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021681"(cerebellar granular layer development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030421"(defecation)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0042995"(cell projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044849"(estrous cycle)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0048477"(oogenesis)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071673"(positive regulation of smooth muscle cell chemotaxis)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:0106091"(glial cell projection elongation)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:1904036"(negative regulation of epithelial cell apoptotic process)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000762(PTN/MK heparin-binding protein)|interpro:IPR020089|interpro:IPR020090|interpro:IPR020091|interpro:IPR020092|interpro:IPR037122|interpro:IPR038130|refseq:NP_001012335.1|refseq:NP_001012336.1|refseq:NP_001278410.1|refseq:NP_034914.1|dip:DIP-5791N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:lf0KMWJoUzamS1IZ4O3zLc2Aarc10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P97820	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-644181	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:m4k4_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase kinase 4(gene name synonym)|uniprotkb:HPK/GCK-like kinase HGK(gene name synonym)|uniprotkb:Nck-interacting kinase(gene name synonym)|uniprotkb:Map4k4(gene name)|psi-mi:Map4k4(display_short)|uniprotkb:Nik(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001239129.1|refseq:NP_001239130.1|refseq:NP_001239131.1|refseq:NP_032722.2|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-2559580|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032014"(positive regulation of ARF protein signal transduction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-40973N|mint:P97820	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:laMTX6DrOoTz4D8zxLP5ohzqKyw10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q5XJV6	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726286|uniprotkb:A6BLZ0|uniprotkb:Q52KF1	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:lmtk3_mouse(display_long)|uniprotkb:Apoptosis-associated tyrosine kinase 3(gene name synonym)|uniprotkb:Lemur tyrosine kinase 3(gene name synonym)|uniprotkb:Lmtk3(gene name)|psi-mi:Lmtk3(display_short)|uniprotkb:Aatyk3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:Q5XJV6|refseq:NP_001005511.2|refseq:NP_001277919.1|refseq:XP_006541027.1|refseq:XP_017177816.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:FJgk1CZB0wgIbl5dhC81Wy7TRJE10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:B7ZNG0	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16356783|uniprotkb:B2RUB1	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:kif7_mouse(display_long)|uniprotkb:Kif7(gene name)|psi-mi:Kif7(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0003279"(cardiac septum development)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0035904"(aorta development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|go:"GO:0036064"(ciliary basal body)|reactome:R-MMU-5610787|reactome:R-MMU-5632684|dip:DIP-61761N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:WZ5rB98fyn0jmOSroekMVmjUZMM10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q61771	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-6395332|ensembl:ENSMUSP00000028977|uniprotkb:Q3UFZ8|uniprotkb:Q8BNH4	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:kif3b_mouse(display_long)|uniprotkb:Kif3b(gene name)|psi-mi:Kif3b(display_short)|uniprotkb:Microtubule plus end-directed kinesin motor 3B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000027475(gene)|ensembl:ENSMUST00000028977(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016939"(kinesin II complex)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0036372"(opsin transport)|go:"GO:0042073"(intraciliary transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0060271"(cilium assembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0120170"(intraciliary transport particle B binding)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-MMU-2132295|reactome:R-MMU-5620924|reactome:R-MMU-6811434|reactome:R-MMU-983189|refseq:NP_032470.3	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:JsWP3UOgu6c3iZWc6pr3aU+hNrs10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q07113	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-2891155|ensembl:ENSMUSP00000024599|uniprotkb:Q61822|uniprotkb:Q6LED1	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:mpri_mouse(display_long)|uniprotkb:Igf2r(gene name)|psi-mi:Igf2r(display_short)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:Q07113|reactome:R-MMU-432722|reactome:R-MMU-6798695|reactome:R-MMU-6811440|reactome:R-MMU-8856825|reactome:R-MMU-8856828|ensembl:ENSMUSG00000023830(gene)|ensembl:ENSMUST00000024599(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001889"(liver development)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|refseq:NP_034645.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:sqdDRrqMg68UCTjHNnqZACflsEs10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8K4P8	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726252|uniprotkb:D3YZ67|uniprotkb:Q6A086|uniprotkb:Q8BIA6|uniprotkb:Q8BKC2|uniprotkb:Q8BKL3|uniprotkb:Q8BKZ8|ensembl:ENSMUSP00000106145	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:hecw1_mouse(display_long)|uniprotkb:HECT, C2 and WW domain-containing protein 1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HECW1(gene name synonym)|uniprotkb:NEDD4-like E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:Hecw1(gene name)|psi-mi:Hecw1(display_short)|uniprotkb:Kiaa0322(gene name synonym)|uniprotkb:Nedl1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001074817.3|refseq:XP_006516873.1|refseq:XP_006516874.1|refseq:XP_006516875.1|ensembl:ENSMUSG00000021301(gene)|ensembl:ENSMUST00000110516(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR032348|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|interpro:IPR037795|interpro:IPR040524|reactome:R-MMU-4641258	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:wgXzbaueyriv924jEMcwhmOJyLM10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:A2A699	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726238|ensembl:ENSMUSP00000038486|uniprotkb:B7ZC48|uniprotkb:Q05CH6|uniprotkb:Q6P2L1	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:f1712_mouse(display_long)|uniprotkb:Fam171a2(gene name)|psi-mi:Fam171a2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000034685(gene)|ensembl:ENSMUST00000049057(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR018890|refseq:NP_954670.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:7NVAzhDbIF2fudv/6EvN9nU/Ops10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9Z2H5	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-774482|uniprotkb:Q3U3L1|uniprotkb:Q3UHP7|uniprotkb:Q80U34|uniprotkb:Q8K204	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:e41l1_mouse(display_long)|uniprotkb:Neuronal protein 4.1(gene name synonym)|uniprotkb:Epb41l1(gene name)|psi-mi:Epb41l1(display_short)|uniprotkb:Epb4(gene name synonym)|uniprotkb:Epb4.1l1(gene name synonym)|uniprotkb:Kiaa0338(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001278049.1|refseq:NP_001278051.1|refseq:NP_001278052.1|refseq:NP_001006665.1|refseq:NP_038538.1|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR019749|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019747|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR018979|interpro:IPR018980|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR007477(SAB)|interpro:IPR029071|interpro:IPR035963|mint:Q9Z2H5|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0097060"(synaptic membrane)|reactome:R-MMU-399719|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:Lu31NnWhI356njHUtKbBlaO6nWE10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9QXS6	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-445208|uniprotkb:A2CG16|uniprotkb:Q3V234|uniprotkb:Q922X1|uniprotkb:Q9QXS5|ensembl:ENSMUSP00000021950	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:dreb_mouse(display_long)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:Dbn1(gene name)|psi-mi:Dbn1(display_short)|uniprotkb:Drba(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001170842.1|refseq:NP_001170843.1|refseq:NP_062787.2|ensembl:ENSMUSG00000034675(gene)|ensembl:ENSMUST00000021950(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0005856"(cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048699"(generation of neurons)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0098828"(modulation of inhibitory postsynaptic potential)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:1904113"(negative regulation of muscle filament sliding)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q9QXS6|reactome:R-MMU-9013405|reactome:R-MMU-9013407|reactome:R-MMU-9013418|reactome:R-MMU-9013422	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:ArZUGZNIUfSwoIketPcPCXlSM8410090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q505D1	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-4286346|ensembl:ENSMUSP00000014640	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:anr28_mouse(display_long)|uniprotkb:Ankrd28(gene name)|psi-mi:Ankrd28(display_short)|uniprotkb:Ankyrin repeat domain-containing protein 28(gene name synonym)|uniprotkb:Phosphatase interactor targeting protein hnRNP K(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001019775.1|ensembl:ENSMUSG00000014496(gene)|ensembl:ENSMUST00000014640(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|reactome:R-MMU-171319|reactome:R-MMU-204005	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:jhZYM9tAWCCd4hV3c/YAyNi0Y3s10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P62484	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-15791842|ensembl:ENSMUSP00000058754|uniprotkb:Q6PHU3	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:abi2_mouse(display_long)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:Abi2(gene name)|psi-mi:Abi2(display_short)|uniprotkb:Abelson interactor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000026782(gene)|ensembl:ENSMUST00000052332(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007611"(learning or memory)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_001185499.1|refseq:NP_001185500.1|refseq:NP_937760.1|dip:DIP-48418N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:A5p3uqPuid61N78yiLHbnxA64mQ10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P63101	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P61982	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-359843|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q4FK44|uniprotkb:Q3UFD6|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSMUSP00000051223|ensembl:ENSMUSP00000143631	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:1433g_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_061359.2|ensembl:ENSMUSG00000051391(gene)|ensembl:ENSMUST00000055808(transcript)|ensembl:ENSMUST00000198270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61982|reactome:R-MMU-111447|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-9614399	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P62259	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9CQV8	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-771608|uniprotkb:O70455|uniprotkb:Q3TY33|uniprotkb:Q3UAN6|ensembl:ENSMUSP00000018470	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:1433b_mouse(display_long)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Ywhab(gene name)|psi-mi:Ywhab(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_061223.2|refseq:XP_006499972.1|reactome:R-MMU-111447|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-170968|reactome:R-MMU-2028269|reactome:R-MMU-392517|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-75035|reactome:R-MMU-9614399|ensembl:ENSMUSG00000018326(gene)|ensembl:ENSMUST00000018470(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:4GNT|rcsb pdb:5F74|rcsb pdb:5WFU|rcsb pdb:5WFX	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:g94luGOxfq+Jbi0ztZ7gbAkp+2A10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8R5H6	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-774719|uniprotkb:Q91W51|uniprotkb:Q9ERQ9|ensembl:ENSMUSP00000019975|ensembl:ENSMUSP00000101148	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:wasf1_mouse(display_long)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Wasf1(gene name)|psi-mi:Wasf1(display_short)|uniprotkb:Wave1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_114083.1|refseq:XP_006512995.1|ensembl:ENSMUSG00000019831(gene)|ensembl:ENSMUST00000019975(transcript)|ensembl:ENSMUST00000105509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8R5H6|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013423	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:t+4F2ap7lNjE/AGuIwMhel4YknU10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q02053	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-2310520|uniprotkb:A6H6S6|uniprotkb:P31253|uniprotkb:Q542H8|ensembl:ENSMUSP00000001989|ensembl:ENSMUSP00000086626	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:uba1_mouse(display_long)|uniprotkb:Uba1(gene name)|psi-mi:Uba1(display_short)|uniprotkb:Sbx(gene name synonym)|uniprotkb:Ube1(gene name synonym)|uniprotkb:Ube1ax(gene name synonym)|uniprotkb:Ube1x(gene name synonym)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Ubiquitin-like modifier-activating enzyme 1 X(gene name synonym)|uniprotkb:Ubiquitin-activating enzyme E1 X(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001129557.1|refseq:NP_001263245.1|refseq:NP_001263246.1|refseq:NP_033483.2|ensembl:ENSMUSG00000001924(gene)|ensembl:ENSMUST00000001989(transcript)|ensembl:ENSMUST00000089217(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030057"(desmosome)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0032446"(protein modification by small protein conjugation)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:Q02053|rcsb pdb:1Z7L|rcsb pdb:2LZJ|rcsb pdb:2V31|reactome:R-MMU-8866652|reactome:R-MMU-983168|interpro:IPR019572	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:358Lm1CC2dWXeDL+IXAM2KaOlqM10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q7TQD2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-2933886|ensembl:ENSMUSP00000022057	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:tppp_mouse(display_long)|uniprotkb:Tppp(gene name)|psi-mi:Tppp(display_short)|uniprotkb:25 kDa brain-specific protein(gene name synonym)|uniprotkb:TPPP/p25(gene name synonym)|uniprotkb:p25-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000021573(gene)|ensembl:ENSMUST00000022057(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032288"(myelin assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051301"(cell division)|go:"GO:0051418"(microtubule nucleation by microtubule organizing center)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097427"(microtubule bundle)|go:"GO:0150051"(postsynaptic Golgi apparatus)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR008907(P25-alpha)|interpro:IPR011992(EF-Hand type)|interpro:IPR030792|go:"GO:0014003"(oligodendrocyte development)|refseq:NP_878259.1|refseq:XP_006517472.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:m6g+6uIsfnaSQDNzM4B9FTNwTSA10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8BYI9	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-774167|uniprotkb:A2RT70|uniprotkb:O88717|ensembl:ENSMUSP00000107298|ensembl:ENSMUSP00000141553	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:tenr_mouse(display_long)|uniprotkb:Restrictin(gene name synonym)|uniprotkb:Janusin(gene name synonym)|uniprotkb:Neural recognition molecule J1-160/180(gene name synonym)|uniprotkb:Tnr(gene name)|psi-mi:Tnr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_071707.2|refseq:XP_006496805.1|refseq:XP_006496806.1|refseq:XP_006496807.1|ensembl:ENSMUSG00000015829(gene)|ensembl:ENSMUST00000111669(transcript)|ensembl:ENSMUST00000192069(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0045121"(membrane raft)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048692"(negative regulation of axon extension involved in regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072534"(perineuronal net)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098966"(perisynaptic extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR033079|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:Q8BYI9|reactome:R-MMU-3000178	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:K7s7yPGS4RvIe+thCkAZIFGjNRA10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q71LX4	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-2255655|uniprotkb:E9QM49|uniprotkb:Q8BWK0	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:tln2_mouse(display_long)|uniprotkb:Tln2(gene name)|psi-mi:Tln2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	mint:Q71LX4|refseq:NP_001074711.2|dip:DIP-53098N|go:"GO:0001726"(ruffle)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0045202"(synapse)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036723|interpro:IPR037438|rcsb pdb:3G9W|interpro:IPR036476	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:fPA7JK3ca5p+y6dQlF+Srehsd2A10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q6ZQ29	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-11075873|uniprotkb:Q7TSS8|ensembl:ENSMUSP00000112963	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:taok2_mouse(display_long)|uniprotkb:Taok2(gene name)|psi-mi:Taok2(display_short)|uniprotkb:Kiaa0881(gene name synonym)|uniprotkb:Thousand and one amino acid protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001157246.1|refseq:NP_001157247.1|ensembl:ENSMUSG00000059981(gene)|ensembl:ENSMUST00000117394(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007409"(axonogenesis)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030424"(axon)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150019"(basal dendrite morphogenesis)|go:"GO:0150020"(basal dendrite arborization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:3C4cqoGaWAJFiVl7jRPn7kGlaCc10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8CC35	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-774691|uniprotkb:Q99JI0|ensembl:ENSMUSP00000125272	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:synpo_mouse(display_long)|uniprotkb:Synpo(gene name)|psi-mi:Synpo(display_short)|uniprotkb:Kiaa1029(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000043079(gene)|ensembl:ENSMUST00000143275(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0097444"(spine apparatus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098886"(modification of dendritic spine)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099588"(positive regulation of postsynaptic cytosolic calcium concentration)|go:"GO:1905355"(spine apparatus assembly)|interpro:IPR028753	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:X85lScd6IVk7dALEA55e9/YC9Rw10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:F6SEU4	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-5797569|ensembl:ENSMUSP00000141686	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:sygp1_mouse(display_long)|uniprotkb:Syngap1(gene name)|psi-mi:Syngap1(display_short)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001268420.1|ensembl:ENSMUSG00000067629(gene)|ensembl:ENSMUST00000194598(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:F6SEU4|rcsb pdb:5JXC|reactome:R-MMU-5658442	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:X1QOpwn0EU5av7G5/QRYmQopTdM10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q68FG2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-2255511|ensembl:ENSMUSP00000008991	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:q68fg2_mouse(display_long)|uniprotkb:Sptbn2(gene name)|psi-mi:Sptbn2(display_short)|uniprotkb:Spnb3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_067262.1|refseq:XP_006531767.1|refseq:XP_006531768.1|ensembl:ENSMUSG00000067889(gene)|ensembl:ENSMUST00000008991(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008091"(spectrin)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0030534"(adult behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051693"(actin filament capping)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098918"(structural constituent of synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:0099189"(postsynaptic spectrin-associated cytoskeleton)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-MMU-2132295|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:2F7U0dl21KxXpc9Z2sk7D/wzQvM10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q62261	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:E9PX29	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726177|ensembl:ENSMUSP00000011895	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:e9px29_mouse(display_long)|uniprotkb:Sptbn4(gene name)|psi-mi:Sptbn4(display_short)|uniprotkb:Spnb4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000011751(gene)|ensembl:ENSMUST00000011895(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007409"(axonogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008091"(spectrin)|go:"GO:0009566"(fertilization)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019902"(phosphatase binding)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022414"(reproductive process)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0030534"(adult behavior)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034613"(cellular protein localization)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0043203"(axon hillock)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0051693"(actin filament capping)|go:"GO:0061337"(cardiac conduction)|go:"GO:0070852"(cell body fiber)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|rcsb pdb:6M3Q|rcsb pdb:6M3R|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|go:"GO:0002028"(regulation of sodium ion transport)|refseq:NP_115999.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:3opwQ0kPX0QazJZ879BT5RmTr6A10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P16546	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-911063|uniprotkb:A3KGU6|uniprotkb:Q8K380|uniprotkb:Q9CT05|uniprotkb:A3KGU8|ensembl:ENSMUSP00000092697	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:sptn1_mouse(display_long)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym)|uniprotkb:Spta2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	dip:DIP-37712N|ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000095083(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032437"(cuticular plate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:P16546|reactome:R-MMU-264870|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:UVB6Kv+PBlqDH3OLoGjxm5oYVPQ10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q61548	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-775174|uniprotkb:Q61547|uniprotkb:Q8K0D4	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ap180_mouse(display_long)|uniprotkb:Clathrin coat-associated protein AP180(gene name synonym)|uniprotkb:91 kDa synaptosomal-associated protein(gene name synonym)|uniprotkb:Phosphoprotein F1-20(gene name synonym)|uniprotkb:Snap91(gene name)|psi-mi:Snap91(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001264911.1|refseq:NP_001264915.1|refseq:NP_038697.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|refseq:XP_006510957.1|refseq:XP_006510963.1|interpro:IPR030428|mint:Q61548|go:"GO:0000149"(SNARE binding)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043679"(axon terminus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1904006"(negative regulation of phospholipase D activity)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|reactome:R-MMU-8856825|reactome:R-MMU-8856828	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:uew/lk0YJ8j0CQULEZaC/qLlLF810090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P97797	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-644732|uniprotkb:O08907|uniprotkb:O35924|uniprotkb:O88555|uniprotkb:O88556|uniprotkb:P97796|uniprotkb:Q8R559|uniprotkb:Q9QX57|uniprotkb:Q9WTN4|ensembl:ENSMUSP00000049022|ensembl:ENSMUSP00000124048|uniprotkb:A0A0R4J1Z7|uniprotkb:E0CYM8|uniprotkb:E9QPT7	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:shps1_mouse(display_long)|uniprotkb:Inhibitory receptor SHPS-1(gene name synonym)|uniprotkb:Signal-regulatory protein alpha-1(gene name synonym)|uniprotkb:MyD-1 antigen(gene name synonym)|uniprotkb:Brain Ig-like molecule with tyrosine-based activation motifs(gene name synonym)|uniprotkb:p84(gene name synonym)|uniprotkb:CD172 antigen-like family member A(gene name synonym)|uniprotkb:Sirp(gene name synonym)|uniprotkb:Sirpa(gene name)|psi-mi:Sirpa(display_short)|uniprotkb:Bit(gene name synonym)|uniprotkb:Myd1(gene name synonym)|uniprotkb:Shps1(gene name synonym)|uniprotkb:Ptpns1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:XP_017172050.1|refseq:NP_001277950.1|refseq:XP_006499049.1|refseq:XP_017172057.1|refseq:NP_001171118.1|refseq:NP_031573.2|ensembl:ENSMUSG00000037902(gene)|ensembl:ENSMUST00000049262(transcript)|ensembl:ENSMUST00000161620(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071349"(cellular response to interleukin-12)|go:"GO:0071641"(negative regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0097530"(granulocyte migration)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P97797|rcsb pdb:2YZ1|reactome:R-MMU-202733|reactome:R-MMU-2172127|reactome:R-MMU-391160|reactome:R-MMU-6798695|go:"GO:0050765"(negative regulation of phagocytosis)|refseq:NP_001277948.1|refseq:NP_001277949.1|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|refseq:XP_017172058.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:v0FShADF6c2OXAD2gmm2P0Kkv8c10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q80Z38	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-770338|uniprotkb:E9QPH7|uniprotkb:Q3UTK4|uniprotkb:Q5DU07	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:shan2_mouse(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)|uniprotkb:Kiaa1022(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001074839.2|refseq:NP_001106844.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001452(Src homology-3)|refseq:XP_006508596.1|reactome:R-MMU-6794361|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0043005"(neuron projection)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:OTohbAMxKtx7/WWwWXDc+c24HvQ10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:D3YZU1	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-2314988|ensembl:ENSMUSP00000103571	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:shan1_mouse(display_long)|uniprotkb:Shank1(gene name)|psi-mi:Shank1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001029287.1|refseq:XP_006540927.1|ensembl:ENSMUSG00000038738(gene)|ensembl:ENSMUST00000107938(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:TbxBmjjabypLqTlAx9zbkSAAzpk10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:O55131	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-772161	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:sept7_mouse(display_long)|uniprotkb:Septin7(gene name)|psi-mi:Septin7(display_short)|uniprotkb:CDC10 protein homolog(gene name synonym)|uniprotkb:Cdc10(gene name synonym)|uniprotkb:Sept7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001192296.1|interpro:IPR016491(Septin)|interpro:IPR008115(Septin 7)|interpro:IPR030379|interpro:IPR027417|mint:O55131|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0005938"(cell cortex)|go:"GO:0005940"(septin ring)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0030496"(midbody)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031105"(septin complex)|go:"GO:0031270"(pseudopodium retraction)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032156"(septin cytoskeleton)|go:"GO:0032160"(septin filament array)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0048668"(collateral sprouting)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|reactome:R-MMU-5687128	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:VULb4UyoWVn5vRWIzERa9YQJIYo10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9Z1S5	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-772112|uniprotkb:Q3TNZ2|uniprotkb:Q7TNT7	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:sept3_mouse(display_long)|uniprotkb:Septin3(gene name)|psi-mi:Septin3(display_short)|uniprotkb:Sep3(gene name synonym)|uniprotkb:Sept3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_036019.2|interpro:IPR016491(Septin)|interpro:IPR008114(Septin 3)|interpro:IPR030379|interpro:IPR027417|mint:Q9Z1S5|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005940"(septin ring)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098793"(presynapse)|go:"GO:0099569"(presynaptic cytoskeleton)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:bh+Ipxn2l+rYj60pLw1/8IB04qw10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P70336	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-771800|uniprotkb:Q8BR64|uniprotkb:Q8CBR0|uniprotkb:A5XDA7	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:rock2_mouse(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 2(gene name synonym)|uniprotkb:p164 ROCK-2(gene name synonym)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase II(gene name synonym)|uniprotkb:Rock2(gene name)|psi-mi:Rock2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_033098.2|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR015008(Rho Binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011072(HR1 rho-binding repeat)|mint:P70336|interpro:IPR037311|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0150033"(negative regulation of protein localization to lysosome)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5627117|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013407|reactome:R-MMU-9013422	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:XGh4GUDWts/RI6osd4zKXeh0lAE10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9EQZ6	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-772212|uniprotkb:Q8VIP9|uniprotkb:Q9CW52|uniprotkb:Q9Z1P0|ensembl:ENSMUSP00000088336	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:rpgf4_mouse(display_long)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor II(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 2(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 2(gene name synonym)|uniprotkb:cAMP-dependent Rap1 guanine-nucleotide exchange factor(gene name synonym)|uniprotkb:Rapgef4(gene name)|psi-mi:Rapgef4(display_short)|uniprotkb:Cgef2(gene name synonym)|uniprotkb:Epac2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_062662.1|refseq:NP_001191094.1|refseq:NP_001191095.1|dip:DIP-32333N|ensembl:ENSMUSG00000049044(gene)|ensembl:ENSMUST00000090826(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030552"(cAMP binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044316"(cone cell pedicle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1904457"(positive regulation of neuronal action potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|rcsb pdb:1O7F|rcsb pdb:2BYV|rcsb pdb:3CF6|rcsb pdb:4F7Z|rcsb pdb:4MGI|rcsb pdb:4MGK|rcsb pdb:4MGY|rcsb pdb:4MGZ|rcsb pdb:4MH0|reactome:R-MMU-354192|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:E6oFNR3wXazvvq3wWWxfn4CW5F410090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P63001	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P63318	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-397096|uniprotkb:P05697|ensembl:ENSMUSP00000097874	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:kpcg_mouse(display_long)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_035232.1|ensembl:ENSMUSG00000078816(gene)|ensembl:ENSMUST00000100301(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0005829"(cytosol)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|interpro:IPR020454|interpro:IPR035892|mint:P63318|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-416993|reactome:R-MMU-5099900|reactome:R-MMU-76005	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P16054	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-298451|ensembl:ENSMUSP00000094873|ensembl:ENSMUSP00000094874	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:kpce_mouse(display_long)|uniprotkb:Prkce(gene name)|psi-mi:Prkce(display_short)|uniprotkb:Pkce(gene name synonym)|uniprotkb:Pkcea(gene name synonym)|uniprotkb:nPKC-epsilon(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000045038(gene)|ensembl:ENSMUST00000097274(transcript)|ensembl:ENSMUST00000097275(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027274|interpro:IPR034669|interpro:IPR035892|reactome:R-MMU-114508|reactome:R-MMU-1250196|reactome:R-MMU-1489509|reactome:R-MMU-2029485|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0005829"(cytosol)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035276"(ethanol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071944"(cell periphery)|go:"GO:0043278"(response to morphine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046872"(metal ion binding)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001031"(positive regulation of cellular glucuronidation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050996"(positive regulation of lipid catabolic process)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0051301"(cell division)|refseq:NP_035234.1|dip:DIP-31066N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:LBpr5ejW6fnkKwlXL6akJYv3H1M10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P68404	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q7TSI3	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-4286465|uniprotkb:Q80TJ4|ensembl:ENSMUSP00000066736	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:pp6r1_mouse(display_long)|uniprotkb:Ppp6r1(gene name)|psi-mi:Ppp6r1(display_short)|uniprotkb:Kiaa1115(gene name synonym)|uniprotkb:Pp6r1(gene name synonym)|uniprotkb:Saps1(gene name synonym)|uniprotkb:SAPS domain family member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_766482.2|refseq:XP_011248858.1|ensembl:ENSMUSG00000052296(gene)|ensembl:ENSMUST00000064099(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007587(SIT4 phosphatase-associated protein)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-204005	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:ET7IE429eaRNAHpRwjds5XF7nrA10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P63328	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-397208|uniprotkb:P12816|uniprotkb:P20652|uniprotkb:Q3UCU1|uniprotkb:Q64135|ensembl:ENSMUSP00000053101	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:pp2ba_mouse(display_long)|uniprotkb:Ppp3ca(gene name)|psi-mi:Ppp3ca(display_short)|uniprotkb:Calna(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_032939.1|refseq:NP_001280551.1|ensembl:ENSMUSG00000028161(gene)|ensembl:ENSMUST00000056758(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042383"(sarcolemma)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P63328|rcsb pdb:4ORB|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|dip:DIP-31543N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:98yAyDGZZxKYOv22ejceyfJbvao10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P63087	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-80040|uniprotkb:O09186|uniprotkb:O09189|uniprotkb:P37139|uniprotkb:Q64679|ensembl:ENSMUSP00000099587	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:pp1g_mouse(display_long)|uniprotkb:Ppp1cc(gene name)|psi-mi:Ppp1cc(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|rcsb pdb:4V0U|rcsb pdb:4V0V|rcsb pdb:4V0W|rcsb pdb:4V0X|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-68877|reactome:R-MMU-9648025|go:"GO:0005856"(cytoskeleton)|ensembl:ENSMUSG00000004455(gene)|ensembl:ENSMUST00000102528(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_038664.2|refseq:XP_006508478.1|refseq:XP_006530263.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:67YjuOIxqIl6Qj+bQnfLBo4iRAg10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P17742	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-1206043|uniprotkb:Q9CWJ5|uniprotkb:Q9R137|ensembl:ENSMUSP00000117987	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ppia_mouse(display_long)|uniprotkb:Ppia(gene name)|psi-mi:Ppia(display_short)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:SP18(gene name synonym)|uniprotkb:Rotamase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_032933.1|reactome:R-MMU-210991|reactome:R-MMU-6798695|rcsb pdb:6FK1|ensembl:ENSMUSG00000071866(gene)|ensembl:ENSMUST00000132846(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:P17742	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:VwIoW2yfdaAEwZj6MfekFYqkZjw10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9Z1B3	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-397636|uniprotkb:Q62075|uniprotkb:Q8K5A5|uniprotkb:Q8K5A6|uniprotkb:Q9Z0E5|uniprotkb:Q9Z2T5|uniprotkb:Q6PDH1|ensembl:ENSMUSP00000105743	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:plcb1_mouse(display_long)|uniprotkb:Plcb1(gene name)|psi-mi:Plcb1(display_short)|uniprotkb:Phosphoinositide phospholipase C-beta-1(gene name synonym)|uniprotkb:Phospholipase C-beta-1(gene name synonym)|uniprotkb:PLC-154(gene name synonym)|uniprotkb:Plcb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001139302.1|refseq:NP_062651.2|ensembl:ENSMUSG00000051177(gene)|ensembl:ENSMUST00000110116(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001556"(oocyte maturation)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031161"(phosphatidylinositol catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032957"(inositol trisphosphate metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034284"(response to monosaccharide)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0060466"(activation of meiosis involved in egg activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0080154"(regulation of fertilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099178"(regulation of retrograde trans-synaptic signaling by endocanabinoid)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902618"(cellular response to fluoride)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1905631"(cellular response to glyceraldehyde)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000438"(negative regulation of monocyte extravasation)|go:"GO:2000560"(positive regulation of CD24 production)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR009535(Protein of unknown function DUF1154)|go:"GO:0043209"(myelin sheath)|interpro:IPR014815(PLC-beta, C-terminal)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR028400|interpro:IPR035892|interpro:IPR037862|interpro:IPR042531|mint:Q9Z1B3|reactome:R-MMU-112043|reactome:R-MMU-1855204|reactome:R-MMU-399997|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-418217|reactome:R-MMU-434316|reactome:R-MMU-500657|interpro:IPR011992(EF-Hand type)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:OdorlKjHTBQOboAmplMz5kjIwAs10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q810U3	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-774147|ensembl:ENSMUSP00000092148	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:nfasc_mouse(display_long)|uniprotkb:Nfasc(gene name)|psi-mi:Nfasc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_874385.1|dip:DIP-31976N|ensembl:ENSMUSG00000026442(gene)|ensembl:ENSMUST00000094569(transcript)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005918"(septate junction)|go:"GO:0007411"(axon guidance)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0033010"(paranodal junction)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043194"(axon initial segment)|go:"GO:0043209"(myelin sheath)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0050808"(synapse organization)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0097454"(Schwann cell microvillus)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026965|interpro:IPR026966|interpro:IPR036116|interpro:IPR036179|interpro:IPR043204|reactome:R-MMU-447043|reactome:R-MMU-6798695	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:yQIOKw2oQ41AsAhoSu/Ok13Zs6U10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P08553	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-445188|uniprotkb:A2VCT5|uniprotkb:Q0VDM8|uniprotkb:Q3HRJ6|uniprotkb:Q3TNS4|uniprotkb:Q3TPK2|uniprotkb:Q61961|uniprotkb:Q8BQ20	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:nfm_mouse(display_long)|uniprotkb:Neurofilament triplet M protein(gene name synonym)|uniprotkb:160 kDa neurofilament protein(gene name synonym)|uniprotkb:Neurofilament 3(gene name synonym)|uniprotkb:Nefm(gene name)|psi-mi:Nefm(display_short)|uniprotkb:Nef3(gene name synonym)|uniprotkb:Nfm(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_032717.2|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR002957(Keratin, type I)|interpro:IPR039008|interpro:IPR027697|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030424"(axon)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|mint:P08553	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:2HBUZIEhbbrfamAhbq7gyuRUaTk10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P08551	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-445199|uniprotkb:Q8K0Z0|ensembl:ENSMUSP00000022639	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:nfl_mouse(display_long)|uniprotkb:Neurofilament triplet L protein(gene name synonym)|uniprotkb:68 kDa neurofilament protein(gene name synonym)|uniprotkb:Nefl(gene name)|psi-mi:Nefl(display_short)|uniprotkb:Nfl(gene name synonym)|uniprotkb:Nf68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_035040.1|ensembl:ENSMUSG00000022055(gene)|ensembl:ENSMUST00000022639(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027692|interpro:IPR039008|mint:P08551|reactome:R-MMU-438066|reactome:R-MMU-5673001|go:"GO:0098981"(cholinergic synapse)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0040011"(locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051258"(protein polymerization)|go:"GO:0051412"(response to corticosterone)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060074"(synapse maturation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|dip:DIP-31944N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:E8KK2ppZXyLXIlFZp/pjXv7GBEU10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P28660	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-771576|uniprotkb:Q3UPY6|uniprotkb:Q80TX0|uniprotkb:Q8CG49|uniprotkb:Q99KY0|ensembl:ENSMUSP00000028386	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:nckp1_mouse(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Brain protein H19(gene name synonym)|uniprotkb:MH19(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Kiaa0587(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_058661.1|ensembl:ENSMUSG00000027002(gene)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|ensembl:ENSMUST00000028386(transcript)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:P28660|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:NIygMTpuScC4fys7MrAWJD7Hd4M10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9Z0E0	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-775082|uniprotkb:Q3TCW4|uniprotkb:Q80TW1|uniprotkb:Q91YH7|uniprotkb:Q9CW81|uniprotkb:Q9QUQ0|ensembl:ENSMUSP00000030637|ensembl:ENSMUSP00000101722	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ncdn_mouse(display_long)|uniprotkb:Sfap75(gene name synonym)|uniprotkb:Norbin(gene name synonym)|uniprotkb:M-Sema F-associating protein of 75 kDa(gene name synonym)|uniprotkb:Ncdn(gene name)|psi-mi:Ncdn(display_short)|uniprotkb:Kiaa0607(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_036116.3|refseq:XP_006503181.1|refseq:XP_006503182.1|ensembl:ENSMUSG00000028833(gene)|ensembl:ENSMUST00000030637(transcript)|ensembl:ENSMUST00000106116(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045453"(bone resorption)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0098794"(postsynapse)|interpro:IPR008709(Neurochondrin)|interpro:IPR016024(Armadillo-type fold)|mint:Q9Z0E0	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:afzLC/h+kiexMllkeyxpn1btb1U10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P55066	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-774845|uniprotkb:Q6P1E3|uniprotkb:Q8C4F8	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ncan_mouse(display_long)|uniprotkb:Chondroitin sulfate proteoglycan 3(gene name synonym)|uniprotkb:Ncan(gene name)|psi-mi:Ncan(display_short)|uniprotkb:Cspg3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_031815.2|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR018378|interpro:IPR016187(C-type lectin fold)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR000538(Link)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR036179|mint:P55066|go:"GO:0001501"(skeletal system development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007417"(central nervous system development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0045202"(synapse)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0072534"(perineuronal net)|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|reactome:R-MMU-3000178	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:FbEuo7LHWAZLqfPi0o0JVHNX4Y410090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q99104	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-400199|uniprotkb:E9PUE5|ensembl:ENSMUSP00000116028	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:myo5a_mouse(display_long)|uniprotkb:Myo5a(gene name)|psi-mi:Myo5a(display_short)|uniprotkb:Dilute(gene name synonym)|uniprotkb:Dilute myosin heavy chain, non-muscle(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_034994.2|ensembl:ENSMUSG00000034593(gene)|ensembl:ENSMUST00000123128(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000149"(SNARE binding)|go:"GO:0001726"(ruffle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007601"(visual perception)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014046"(dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031585"(regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031982"(vesicle)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032433"(filopodium tip)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042476"(odontogenesis)|go:"GO:0042552"(myelination)|go:"GO:0042641"(actomyosin)|go:"GO:0042642"(actomyosin, myosin complex part)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043473"(pigmentation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0050808"(synapse organization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051643"(endoplasmic reticulum localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099089"(establishment of endoplasmic reticulum localization to postsynapse)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0099640"(axo-dendritic protein transport)|go:"GO:0150103"(reactive gliosis)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|go:"GO:0030318"(melanocyte differentiation)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR037988|mint:Q99104|rcsb pdb:2IX7|rcsb pdb:3WB8|rcsb pdb:4KP3|rcsb pdb:4ZLK|rcsb pdb:6KU0|reactome:R-MMU-2029482|interpro:IPR002710(Dilute)|go:"GO:0030141"(secretory granule)|dip:DIP-29542N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:8QtBlLL4DqB3An4CoCFVmvBEXBg10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9WV34	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-444614|ensembl:ENSMUSP00000017458|uniprotkb:Q3T9W1|uniprotkb:Q3TT52|uniprotkb:Q3URK8|uniprotkb:B1AQF8	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:mpp2_mouse(display_long)|uniprotkb:Protein MPP2(gene name synonym)|uniprotkb:Discs large homolog 2(gene name synonym)|uniprotkb:Mpp2(gene name)|psi-mi:Mpp2(display_short)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_057904.1|ensembl:ENSMUSG00000017314(gene)|ensembl:ENSMUST00000017458(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035602|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q9WV34|go:"GO:0098919"(structural constituent of postsynaptic density)|refseq:XP_006533746.1|refseq:XP_006533747.1|refseq:XP_006533748.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:KythGhvpyj7gkND18iMe73LgdtM10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:O35099	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9QXZ0	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-643248|intact:EBI-2658096|uniprotkb:B1ARU3|uniprotkb:Q4PLL5|uniprotkb:P97394|uniprotkb:P97395|uniprotkb:P97396	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:macf1_mouse(display_long)|uniprotkb:Actin cross-linking family 7(gene name synonym)|uniprotkb:Macf1(gene name)|psi-mi:Macf1(display_short)|uniprotkb:Acf7(gene name synonym)|uniprotkb:Aclp7(gene name synonym)|uniprotkb:Macf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR002017(Spectrin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR001101(Plectin repeat)|interpro:IPR018159|interpro:IPR001452(Src homology-3)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0008104"(protein localization)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|mint:Q9QXZ0|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:niJxpkI45VTa5x73A1tuX/aLXgo10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q80TE7	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-774900	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:lrrc7_mouse(display_long)|uniprotkb:Protein LAP1(gene name synonym)|uniprotkb:Densin-180(gene name synonym)|uniprotkb:Lrrc7(gene name)|psi-mi:Lrrc7(display_short)|uniprotkb:Kiaa1365(gene name synonym)|uniprotkb:Lap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001278381.1|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR032675|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR036034|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6798695|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043194"(axon initial segment)|go:"GO:0043197"(dendritic spine)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:QWCdfe/eQM/ZaaAG2GwZi+Rf87Q10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P28738	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-2506834|uniprotkb:Q6NXI9|ensembl:ENSMUSP00000028102|uniprotkb:Q9Z2F8	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:kif5c_mouse(display_long)|uniprotkb:Kif5c(gene name)|psi-mi:Kif5c(display_short)|uniprotkb:Nkhc2(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000026764(gene)|ensembl:ENSMUST00000028102(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051028"(mRNA transport)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098964"(anterograde dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0150034"(distal axon)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:P28738|rcsb pdb:1VFV|rcsb pdb:1VFW|rcsb pdb:1VFX|rcsb pdb:1VFZ|rcsb pdb:3J6H|rcsb pdb:3WRD|rcsb pdb:3X2T|rcsb pdb:5HLE|refseq:NP_032475.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:GbPyKDztqPG8BP2+44k3TXPuI/010090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:A2CG49	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-770321|uniprotkb:A2CG50|uniprotkb:A2CG51|uniprotkb:A2CG52|uniprotkb:A2CG53|uniprotkb:Q3TYL1|uniprotkb:Q3UTA5|uniprotkb:Q8BTT9|uniprotkb:Q8C4Q2|uniprotkb:Q9CVA9|uniprotkb:Q3TXY8|uniprotkb:B2RXR5|uniprotkb:D3Z559|ensembl:ENSMUSP00000076088	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:kalrn_mouse(display_long)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001157740.1|refseq:XP_006522445.1|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018159|interpro:IPR028570|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSMUSG00000061751(gene)|ensembl:ENSMUST00000076810(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0035176"(social behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042711"(maternal behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046959"(habituation)|mint:A2CG49|rcsb pdb:1WFW|reactome:R-MMU-193648|reactome:R-MMU-3928662|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5687128|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013408|interpro:IPR036865	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:pDqdA2QNbqgLE3eYQXVVW2cxIyo10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q61702	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726158|ensembl:ENSMUSP00000126449|uniprotkb:Q3UEI9	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:itih1_mouse(display_long)|uniprotkb:Itih1(gene name)|psi-mi:Itih1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000006529(gene)|ensembl:ENSMUST00000163118(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010600(Inter-alpha-trypsin inhibitor heavy chain, C-terminal)|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR036465|refseq:NP_001293007.1|refseq:NP_032432.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:hktujK/7kl/BHs3q7Lpa70PP68s10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q5DU25	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-773452|uniprotkb:E9QK46	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:iqec2_mouse(display_long)|uniprotkb:Iqsec2(gene name)|psi-mi:Iqsec2(display_short)|uniprotkb:Kiaa0522(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000904(SEC7-like)|interpro:IPR023394|interpro:IPR033742|refseq:XP_006528908.1|interpro:IPR035999|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900454"(positive regulation of long-term synaptic depression)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:D2kDV/pgwPkXPHcK5+7S9+HS6Wk10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8R0S2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-772277|uniprotkb:Q3TZC3|uniprotkb:Q5DU15|ensembl:ENSMUSP00000098712	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:iqec1_mouse(display_long)|uniprotkb:Iqsec1(gene name)|psi-mi:Iqsec1(display_short)|uniprotkb:Kiaa0763(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001127855.1|ensembl:ENSMUSG00000034312(gene)|ensembl:ENSMUST00000101153(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR030737|interpro:IPR033742|interpro:IPR035999	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:BZg7CaLndE4ak8KXs34YFf9iBRQ10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P46660	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-400482|uniprotkb:Q61958|uniprotkb:Q8VCW5|ensembl:ENSMUSP00000041347	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ainx_mouse(display_long)|uniprotkb:Ina(gene name)|psi-mi:Ina(display_short)|uniprotkb:66 kDa neurofilament protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_666212.3|ensembl:ENSMUSG00000034336(gene)|ensembl:ENSMUST00000037636(transcript)|go:"GO:0005883"(neurofilament)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027703|interpro:IPR039008|mint:P46660	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:amjP0AajB8s2oXmV96wzyfz6evE10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q99JP6	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-6272061|ensembl:ENSMUSP00000117033|uniprotkb:D3Z6N9|uniprotkb:Q9Z215	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:home3_mouse(display_long)|uniprotkb:Homer3(gene name)|psi-mi:Homer3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000003573(gene)|ensembl:ENSMUST00000140212(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q99JP6|reactome:R-MMU-6794361|refseq:NP_001139625.1|refseq:NP_036114.2	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:7IOPI8VTi6aKK/I0tl4AiUUIXIU10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9QWW1	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726117|ensembl:ENSMUSP00000146787|uniprotkb:O89025|uniprotkb:Q9Z0E4	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:home2_mouse(display_long)|uniprotkb:Cupidin(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 2(gene name synonym)|uniprotkb:Homer2(gene name)|psi-mi:Homer2(display_short)|uniprotkb:Vesl2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000025813(gene)|ensembl:ENSMUST00000207983(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|rcsb pdb:1I7A|rcsb pdb:5ZZ9|reactome:R-MMU-6794361|refseq:NP_001157558.1|refseq:NP_001157559.1|refseq:NP_036113.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:QqlsSdZkcnJaG2sLtfGrUV3Os6g10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9Z2Y3	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:O88703	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:O88704	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9WV60	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-400793|ensembl:ENSMUSP00000023507	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:gsk3b_mouse(display_long)|uniprotkb:Gsk3b(gene name)|psi-mi:Gsk3b(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_062801.1|dip:DIP-32446N|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006983"(ER overload response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014043"(negative regulation of neuron maturation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034452"(dynactin binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:Q9WV60|rcsb pdb:4NU1|rcsb pdb:5AIR|rcsb pdb:6AE3|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3371453|reactome:R-MMU-399956|reactome:R-MMU-4641262|reactome:R-MMU-5250924|reactome:R-MMU-5610785|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046849"(bone remodeling)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0106027"(neuron projection organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904780"(negative regulation of protein localization to centrosome)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|ensembl:ENSMUSG00000022812(gene)|ensembl:ENSMUST00000023507(transcript)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:FKe0WkOBBYU0vIJLmcFNMJ+KVHA10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9QYS2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-770623|uniprotkb:Q14DJ9|ensembl:ENSMUSP00000004076	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:grm3_mouse(display_long)|uniprotkb:Gprc1c(gene name synonym)|uniprotkb:Mglur3(gene name synonym)|uniprotkb:Grm3(gene name)|psi-mi:Grm3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_862898.1|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0010467"(gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|ensembl:ENSMUSG00000003974(gene)|ensembl:ENSMUST00000004076(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001234(GPCR, family 3, metabotropic glutamate receptor 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:Q9QYS2|reactome:R-MMU-418594|reactome:R-MMU-420499	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:6YCf0CVHHO8OR8GpAMxCucRLxJE10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q01097	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-400125|uniprotkb:Q9DCB2	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P35436	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-400115|ensembl:ENSMUSP00000032331|ensembl:ENSMUSP00000111501|ensembl:ENSMUSP00000142900	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:nmde1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:Grin2a(gene name)|psi-mi:Grin2a(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_032196.2|reactome:R-MMU-8849932|reactome:R-MMU-9609736|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-438066|go:"GO:0098839"(postsynaptic density membrane)|ensembl:ENSMUSG00000059003(gene)|ensembl:ENSMUST00000032331(transcript)|ensembl:ENSMUST00000115835(transcript)|ensembl:ENSMUST00000199708(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040011"(locomotion)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|refseq:XP_006521857.1|dip:DIP-31567N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:5DMFDOh6NuFArDtKp2gp2IpmhWQ10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P35438	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P62874	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-357152|ensembl:ENSMUSP00000030940|ensembl:ENSMUSP00000101241|ensembl:ENSMUSP00000130123|ensembl:ENSMUSP00000135091|uniprotkb:P04901|uniprotkb:P04697	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:gbb1_mouse(display_long)|uniprotkb:Gnb1(gene name)|psi-mi:Gnb1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000029064(gene)|ensembl:ENSMUST00000030940(transcript)|ensembl:ENSMUST00000105616(transcript)|ensembl:ENSMUST00000165335(transcript)|ensembl:ENSMUST00000176637(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007603"(phototransduction, visible light)|reactome:R-MMU-9009391|reactome:R-MMU-997272|reactome:R-MMU-8964616|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030425"(dendrite)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043209"(myelin sheath)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62874|rcsb pdb:6K41|rcsb pdb:6K42|rcsb pdb:6RMV|reactome:R-MMU-1296041|reactome:R-MMU-202040|reactome:R-MMU-2485179|reactome:R-MMU-381676|reactome:R-MMU-381753|reactome:R-MMU-392170|reactome:R-MMU-392451|reactome:R-MMU-392851|reactome:R-MMU-400042|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418217|reactome:R-MMU-418555|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418597|reactome:R-MMU-420092|reactome:R-MMU-428930|reactome:R-MMU-432040|reactome:R-MMU-456926|reactome:R-MMU-500657|reactome:R-MMU-6814122|reactome:R-MMU-8964315|refseq:NP_001153488.1|refseq:NP_001153489.1|refseq:NP_032168.1|refseq:XP_017175466.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:zP/G70MXiSQpzbyyWFTWrJFQENk10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P15105	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-444858|uniprotkb:Q3TRK7|uniprotkb:Q64432|uniprotkb:Q91VC6|ensembl:ENSMUSP00000083375|ensembl:ENSMUSP00000123157	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:glna_mouse(display_long)|uniprotkb:Glutamate--ammonia ligase(gene name synonym)|uniprotkb:Glul(gene name)|psi-mi:Glul(display_short)|uniprotkb:Glns(gene name synonym)|uniprotkb:Palmitoyltransferase GLUL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_032157.2|go:"GO:0030145"(manganese ion binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0097386"(glial cell projection)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR008146(Glutamine synthetase, catalytic region)|interpro:IPR008147(Glutamine synthetase, beta-Grasp)|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR027302|interpro:IPR027303|interpro:IPR036651|mint:P15105|reactome:R-MMU-210455|reactome:R-MMU-8964539|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|ensembl:ENSMUSG00000026473(gene)|ensembl:ENSMUST00000086199(transcript)|ensembl:ENSMUST00000140685(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0004356"(glutamate-ammonia ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006542"(glutamine biosynthetic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0016595"(glutamate binding)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019676"(ammonia assimilation cycle)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:j6R9fxGLKpiREWpecpdnBY9ftoo10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q6NS60	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16725383|ensembl:ENSMUSP00000124524|ensembl:ENSMUSP00000124754|ensembl:ENSMUSP00000125671|uniprotkb:Q6P7W4|uniprotkb:Q6ZPG1	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:fbx41_mouse(display_long)|uniprotkb:Fbxo41(gene name)|psi-mi:Fbxo41(display_short)|uniprotkb:D6Ertd538e(gene name synonym)|uniprotkb:Kiaa1940(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000047013(gene)|ensembl:ENSMUST00000159062(transcript)|ensembl:ENSMUST00000161078(transcript)|ensembl:ENSMUST00000161546(transcript)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-MMU-8951664|reactome:R-MMU-983168|refseq:NP_001001160.1|refseq:NP_001276603.1|refseq:NP_001276604.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:MbpGArQonCm6vp3gakR01/4W5Fg10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q6PH08	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726089|ensembl:ENSMUSP00000147886|uniprotkb:Q80U20|uniprotkb:Q8CCP1	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:erc2_mouse(display_long)|uniprotkb:CAZ-associated structural protein 1(gene name synonym)|uniprotkb:Erc2(gene name)|psi-mi:Erc2(display_short)|uniprotkb:Cast1(gene name synonym)|uniprotkb:D14Ertd171e(gene name synonym)|uniprotkb:Kiaa0378(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000040640(gene)|ensembl:ENSMUST00000211145(transcript)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048790"(maintenance of presynaptic active zone structure)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|interpro:IPR019323|interpro:IPR030625|refseq:NP_808482.2|refseq:XP_006519013.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:bmubXKmJ7vf/Hxo37UGDaxgYamM10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9WV92	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-911885|uniprotkb:Q69ZT8|ensembl:ENSMUSP00000079098|uniprotkb:Q9R102	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:e41l3_mouse(display_long)|uniprotkb:4.1B(gene name synonym)|uniprotkb:Differentially expressed in adenocarcinoma of the lung protein 1(gene name synonym)|uniprotkb:Epb41l3(gene name)|psi-mi:Epb41l3(display_short)|uniprotkb:Dal1(gene name synonym)|uniprotkb:Epb4.1l3(gene name synonym)|uniprotkb:Kiaa0987(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000024044(gene)|ensembl:ENSMUST00000080208(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043217"(myelin maintenance)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030691|interpro:IPR035963|mint:Q9WV92|reactome:R-MMU-6794361|refseq:NP_038841.1|refseq:XP_011244586.1|refseq:XP_011244591.1|refseq:XP_017172724.1|refseq:XP_017172725.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:51gkxiswTUqQbAUqjGoPthWD7jM10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9JHU4	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-645061|uniprotkb:E9QM71|ensembl:ENSMUSP00000018851	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:dyhc1_mouse(display_long)|uniprotkb:Dhc1(gene name synonym)|uniprotkb:Dyhc(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:Dync1h1(gene name)|psi-mi:Dync1h1(display_short)|uniprotkb:Dnch1(gene name synonym)|uniprotkb:Dnchc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_084514.2|ensembl:ENSMUSG00000018707(gene)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002177"(manchette)|go:"GO:0003341"(cilium movement)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|ensembl:ENSMUST00000018851(transcript)|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|interpro:IPR042219|mint:Q9JHU4|rcsb pdb:3ERR|rcsb pdb:3J1T|rcsb pdb:3J1U|rcsb pdb:3WUQ|rcsb pdb:5AYH|rcsb pdb:6RZA|rcsb pdb:6RZB|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:sbED0xqQpe32T7I8ijeS3Xqlx7010090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P39053	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-397785|ensembl:ENSMUSP00000122679|uniprotkb:A2AN50|uniprotkb:A2AN51|uniprotkb:A2AN54|uniprotkb:A2AN55|uniprotkb:Q3UNM1|uniprotkb:Q5DTN7|uniprotkb:Q61358|uniprotkb:Q61359|uniprotkb:Q61360|uniprotkb:Q6PDM5|uniprotkb:Q8JZZ4|uniprotkb:Q9CSY7|uniprotkb:Q9QXX1	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:dyn1_mouse(display_long)|uniprotkb:Dnm1(gene name)|psi-mi:Dnm1(display_short)|uniprotkb:Dnm(gene name synonym)|uniprotkb:Kiaa4093(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_034195.2|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:P39053|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|ensembl:ENSMUSG00000026825(gene)|ensembl:ENSMUST00000139624(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904645"(response to amyloid-beta)|refseq:NP_001288666.1|refseq:XP_006497721.2|refseq:XP_006497722.2|refseq:XP_006497723.2|refseq:XP_006497724.2|refseq:XP_006497718.2|refseq:XP_017170817.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:wtPz3gwyxU6tAgh5091LQpt099I10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:B1AZP2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-645637|uniprotkb:B1AZP3|uniprotkb:Q3KQQ8|uniprotkb:Q6PD44|uniprotkb:Q6XBF1|uniprotkb:Q80TN3|uniprotkb:Q8R3U9|uniprotkb:B7ZNS1|ensembl:ENSMUSP00000126980	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:dlgp4_mouse(display_long)|uniprotkb:Kiaa0964(gene name synonym)|uniprotkb:Sapap4(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 4(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 4(gene name synonym)|uniprotkb:Dlgap4(gene name)|psi-mi:Dlgap4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001035952.1|refseq:NP_666240.4|refseq:NP_001264115.1|refseq:NP_001035953.1|refseq:NP_001264116.1|refseq:XP_006499403.1|ensembl:ENSMUSG00000061689(gene)|ensembl:ENSMUST00000169464(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023052"(signaling)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030527|mint:B1AZP2|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:Ksjp5jiwjvzSymdyt1kSs8I+1pE10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q6PFD5	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-2308733|uniprotkb:Q6PDX0|uniprotkb:Q6XBF2|ensembl:ENSMUSP00000039724|ensembl:ENSMUSP00000101700	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:dlgp3_mouse(display_long)|uniprotkb:Dlgap3(gene name)|psi-mi:Dlgap3(display_short)|uniprotkb:Dap3(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 3(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:XP_011238839.1|refseq:NP_941020.1|refseq:NP_001289010.1|ensembl:ENSMUSG00000042388(gene)|ensembl:ENSMUST00000046659(transcript)|ensembl:ENSMUST00000106094(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023052"(signaling)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030526|mint:Q6PFD5|rcsb pdb:5IZU|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:mkXYwYR5Snou4RA8d71UDC7G59I10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8BJ42	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-2308675|uniprotkb:Q6XBF3|ensembl:ENSMUSP00000039647|ensembl:ENSMUSP00000119613	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:dlgp2_mouse(display_long)|uniprotkb:Dlgap2(gene name)|psi-mi:Dlgap2(display_short)|uniprotkb:Dap2(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 2(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001139437.1|refseq:NP_766498.2|refseq:XP_017168275.1|ensembl:ENSMUSG00000047495(gene)|ensembl:ENSMUST00000043279(transcript)|ensembl:ENSMUST00000133298(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0043197"(dendritic spine)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030525|reactome:R-MMU-6794361	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:9V3GlRM3AupA70mmFtZ4biXuC9E10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9D415	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q62108	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q91XM9	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-400138|uniprotkb:Q8BXK7|uniprotkb:Q8BYG5|ensembl:ENSMUSP00000102814|uniprotkb:F8VQM7	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:dlg2_mouse(display_long)|uniprotkb:Dlg2(gene name)|psi-mi:Dlg2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000052572(gene)|ensembl:ENSMUST00000107196(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035759|interpro:IPR036028|interpro:IPR036034|mint:Q91XM9|rcsb pdb:2WL7|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6794361|refseq:NP_001229976.1|refseq:NP_035937.2|dip:DIP-31569N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:37/IFbjDNxh87dnN2gglIgDGyIU10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q811D0	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-514290|uniprotkb:Q62402|uniprotkb:Q6PGB5|uniprotkb:Q8CGN7|ensembl:ENSMUSP00000097581|ensembl:ENSMUSP00000110859	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:dlg1_mouse(display_long)|uniprotkb:Synapse-associated protein 97(gene name synonym)|uniprotkb:Embryo-dlg/synapse-associated protein 97(gene name synonym)|uniprotkb:Dlg1(gene name)|psi-mi:Dlg1(display_short)|uniprotkb:Dlgh1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_031888.2|refseq:NP_001239362.1|refseq:NP_001239364.1|refseq:XP_006521831.1|refseq:NP_001239363.1|dip:DIP-31591N|ensembl:ENSMUSG00000022770(gene)|ensembl:ENSMUST00000100001(transcript)|ensembl:ENSMUST00000115205(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034629"|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043219"(lateral loop)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060022"(hard palate development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1902473"(regulation of protein localization to synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903286"(regulation of potassium ion import)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903760"(regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:1903764"(regulation of potassium ion export across plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR015143(L27-1)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q811D0|rcsb pdb:4OAJ|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-8849932	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:b8LjYbiuR2K6/jxhwU1hxBJKX6410090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:O08788	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-776180|uniprotkb:E9QLJ1|uniprotkb:Q3TZG7|ensembl:ENSMUSP00000109552	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:dctn1_mouse(display_long)|uniprotkb:150 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:DAP-150(gene name synonym)|uniprotkb:p150-glued(gene name synonym)|uniprotkb:Dctn1(gene name)|psi-mi:Dctn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_031861.2|dip:DIP-32057N|ensembl:ENSMUSG00000031865(gene)|ensembl:ENSMUST00000113919(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005938"(cell cortex)|go:"GO:0007097"(nuclear migration)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032402"(melanosome transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045171"(intercellular bridge)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061744"(motor behavior)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0099738"(cell cortex region)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1904398"(positive regulation of neuromuscular junction development)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR022157|interpro:IPR036859|mint:O08788|reactome:R-MMU-2132295|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-8854518	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:pqj7TtNDgexEbxqLwksW3eW41bo10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9JLM8	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-771719|uniprotkb:Q6P207|ensembl:ENSMUSP00000050034	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:dclk1_mouse(display_long)|uniprotkb:Doublecortin-like and CAM kinase-like 1(gene name synonym)|uniprotkb:Dclk1(gene name)|psi-mi:Dclk1(display_short)|uniprotkb:Dclk(gene name synonym)|uniprotkb:Dcamkl1(gene name synonym)|uniprotkb:Doublecortin-like kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_064362.1|ensembl:ENSMUSG00000027797(gene)|ensembl:ENSMUST00000054237(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0009615"(response to virus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030900"(forebrain development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003533(Doublecortin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036572|mint:Q9JLM8	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:P3ZZ2GyKcdMimAcekZ8OlLbuciM10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q80TQ2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-943859|uniprotkb:Q80VB3|uniprotkb:Q8BXZ3|uniprotkb:Q8BYL9|uniprotkb:Q8CGB0|ensembl:ENSMUSP00000105254|ensembl:ENSMUSP00000147426|ensembl:ENSMUSP00000148037	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:cyld_mouse(display_long)|uniprotkb:Cyld(gene name)|psi-mi:Cyld(display_short)|uniprotkb:Cyld1(gene name synonym)|uniprotkb:Kiaa0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001121642.1|refseq:NP_001121643.1|refseq:NP_775545.1|refseq:XP_006531477.1|refseq:XP_006531478.1|refseq:XP_006531479.1|refseq:XP_006531480.1|refseq:XP_006531481.1|refseq:XP_011246825.1|refseq:XP_011246826.1|refseq:XP_011246827.1|refseq:XP_017168478.1|dip:DIP-35656N|ensembl:ENSMUSG00000036712(gene)|ensembl:ENSMUST00000109626(transcript)|ensembl:ENSMUST00000209559(transcript)|ensembl:ENSMUST00000211554(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689880|reactome:R-MMU-936440	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:U1ditS+hdqob77g9p8v9kSyOKsE10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q5SQX6	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q7TMB8	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-772928|uniprotkb:Q3U7Q7|uniprotkb:Q5DU50|uniprotkb:Q7TSZ5|uniprotkb:Q80VN6|uniprotkb:Q8CE85|uniprotkb:Q99LY1|uniprotkb:O88558|ensembl:ENSMUSP00000032629|ensembl:ENSMUSP00000127717	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:cyfp1_mouse(display_long)|uniprotkb:Cyfip1(gene name)|psi-mi:Cyfip1(display_short)|uniprotkb:Shyc(gene name synonym)|uniprotkb:Kiaa0068(gene name synonym)|uniprotkb:Sra1(gene name synonym)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001158134.1|refseq:NP_035500.2|refseq:NP_001158133.1|refseq:XP_006540792.1|ensembl:ENSMUSG00000030447(gene)|ensembl:ENSMUST00000032629(transcript)|ensembl:ENSMUST00000163845(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7TMB8|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:u8cObqx85DIdhPYtV2YWyOao3KE10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q9JLV5	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-2551335|ensembl:ENSMUSP00000130738	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:cul3_mouse(display_long)|uniprotkb:Cul3(gene name)|psi-mi:Cul3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUSG00000004364(gene)|ensembl:ENSMUST00000163119(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q9JLV5|rcsb pdb:1IUY|reactome:R-MMU-4641258|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-8932339|reactome:R-MMU-8951664|go:"GO:0030030"(cell projection organization)|reactome:R-MMU-9013418|reactome:R-MMU-9013422|reactome:R-MMU-9706019|reactome:R-MMU-983168|refseq:NP_057925.1|refseq:NP_001300657.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:tSFsLPpnn80evlnxKTXO5olW5Xg10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:B9EJA2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16726062|ensembl:ENSMUSP00000088089|uniprotkb:G3X9L7|uniprotkb:Q69ZB2|uniprotkb:Q8BVG1|uniprotkb:Q8C044	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:cttb2_mouse(display_long)|uniprotkb:Cttnbp2(gene name)|psi-mi:Cttnbp2(display_short)|uniprotkb:Kiaa1758(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUST00000090601(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR002110(Ankyrin)|interpro:IPR019131|interpro:IPR020683|interpro:IPR036770|ensembl:ENSMUSG00000000416(gene)|refseq:NP_525024.1|refseq:XP_006505167.1	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:DCSkzHQr+dNIdM9ELmeBWbxVryg10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q6P9K8	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-771526|uniprotkb:Q6ZPU2|uniprotkb:Q8BWU2|uniprotkb:Q8BX99|uniprotkb:Q9CXH0|ensembl:ENSMUSP00000024958	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:cski1_mouse(display_long)|uniprotkb:CASK-interacting protein 1(gene name synonym)|uniprotkb:Caskin1(gene name)|psi-mi:Caskin1(display_short)|uniprotkb:Kiaa1306(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_082213.2|refseq:XP_006524378.1|ensembl:ENSMUSG00000033597(gene)|ensembl:ENSMUST00000024958(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001452(Src homology-3)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR027013|interpro:IPR032117|interpro:IPR032232|interpro:IPR035495|interpro:IPR035497|interpro:IPR035498|interpro:IPR036028|interpro:IPR036770|mint:Q6P9K8	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:zLkBAG7MLTXtMQ0HlY2ox2AumUE10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:O54991	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-774794|uniprotkb:A2A4K6|ensembl:ENSMUSP00000099398	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:cntp1_mouse(display_long)|uniprotkb:Neurexin-4(gene name synonym)|uniprotkb:Neurexin IV(gene name synonym)|uniprotkb:Paranodin(gene name synonym)|uniprotkb:NCP1(gene name synonym)|uniprotkb:MHDNIV(gene name synonym)|uniprotkb:Cntnap1(gene name)|psi-mi:Cntnap1(display_short)|uniprotkb:Nrxn4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_058062.2|ensembl:ENSMUSG00000017167(gene)|ensembl:ENSMUST00000103109(transcript)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0005886"(plasma membrane)|go:"GO:0005918"(septate junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030424"(axon)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031175"(neuron projection development)|go:"GO:0033010"(paranodal junction)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR028872|interpro:IPR036056|mint:O54991	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:BTW+FjgSUq00WpWGDC6PpQcIowE10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P12960	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-774808|uniprotkb:Q6NXV7|uniprotkb:Q8BR42|uniprotkb:Q8C6A0|ensembl:ENSMUSP00000000109|ensembl:ENSMUSP00000067842|ensembl:ENSMUSP00000133063	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:cntn1_mouse(display_long)|uniprotkb:Neural cell surface protein F3(gene name synonym)|uniprotkb:Cntn1(gene name)|psi-mi:Cntn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001153119.1|refseq:NP_001153120.1|refseq:NP_031753.1|refseq:XP_017171911.1|ensembl:ENSMUSG00000055022(gene)|ensembl:ENSMUST00000000109(transcript)|ensembl:ENSMUST00000068378(transcript)|ensembl:ENSMUST00000169825(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0021549"(cerebellum development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099026"(anchored component of presynaptic membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR036992|mint:P12960	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:TftNvfwJlK/7DTczqiV/IzDxhOM10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:A2AGT5	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-910980|uniprotkb:A0PJ77|uniprotkb:A2AGT6|uniprotkb:B2RRC4|uniprotkb:Q0VGR0|uniprotkb:Q3TML9|uniprotkb:Q3UDY6|uniprotkb:Q9CUN0|uniprotkb:Q4VAE7	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ckap5_mouse(display_long)|uniprotkb:Ckap5(gene name)|psi-mi:Ckap5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_083713.2|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024395|interpro:IPR021133|interpro:IPR034085|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008017"(microtubule binding)|go:"GO:0008542"(visual learning)|go:"GO:0010609"(mRNA localization resulting in posttranscriptional regulation of gene expression)|go:"GO:0022618"(ribonucleoprotein complex assembly)|go:"GO:0030425"(dendrite)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043204"(perikaryon)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046959"(habituation)|go:"GO:0050658"(RNA transport)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061863"(microtubule plus end polymerase)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098794"(postsynapse)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:fUm3RHxuyZP1aUHZq+R7EvuGlWY10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P49025	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-397301|intact:EBI-487846|uniprotkb:O88528|uniprotkb:O88937|uniprotkb:O88938|uniprotkb:Q3UM99|uniprotkb:Q8CIJ1	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ctro_mouse(display_long)|uniprotkb:Cit(gene name)|psi-mi:Cit(display_short)|uniprotkb:Rho-interacting, serine/threonine-protein kinase 21(gene name synonym)|uniprotkb:Crik(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR017405(Citron Rho-interacting kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|refseq:XP_006530214.1|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001726"(ruffle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR037708|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005856"(cytoskeleton)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048699"(generation of neurons)|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-5625900	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:8kykadVIiyk12GjGCZNn0bQ13C010090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P47754	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-299188|ensembl:ENSMUSP00000015877	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:caza2_mouse(display_long)|uniprotkb:Capza2(gene name)|psi-mi:Capza2(display_short)|uniprotkb:Cappa2(gene name synonym)|uniprotkb:CapZ alpha-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	ensembl:ENSMUST00000015877(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P47754|reactome:R-MMU-2132295|reactome:R-MMU-3371497|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-879415|reactome:R-MMU-983231|ensembl:ENSMUSG00000015733(gene)|refseq:NP_031630.1|dip:DIP-31382N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:9nxfEbrpHlDtTYwSvHAJvZLLweo10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q923T9	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-771638|uniprotkb:Q3U3H3|uniprotkb:Q8VED3|ensembl:ENSMUSP00000071720	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:kcc2g_mouse(display_long)|uniprotkb:Camk2g(gene name)|psi-mi:Camk2g(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001034227.1|refseq:NP_001034228.1|refseq:NP_848712.2|ensembl:ENSMUSG00000021820(gene)|ensembl:ENSMUST00000071816(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q923T9|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:pbJqcEUQJQRnAwcKozmS72n9s1w10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q6PHZ2	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-2308458|uniprotkb:Q3UF87|uniprotkb:Q3UQH9|uniprotkb:Q5DTK4|uniprotkb:Q8CAC5|uniprotkb:Q9CZE2|ensembl:ENSMUSP00000143504	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:kcc2d_mouse(display_long)|uniprotkb:Camk2d(gene name)|psi-mi:Camk2d(display_short)|uniprotkb:Kiaa4163(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001020609.1|refseq:NP_076302.1|refseq:NP_001020610.1|refseq:NP_001280592.1|refseq:NP_001280593.1|dip:DIP-47638N|ensembl:ENSMUSG00000053819(gene)|ensembl:ENSMUST00000199300(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031432"(titin binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q6PHZ2|rcsb pdb:6BAB|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:z2mz73Kq9gwpKgo2Todn0IxQpSI10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P28652	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P11798	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q91XV3	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-772877|ensembl:ENSMUSP00000053943	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:basp1_mouse(display_long)|uniprotkb:Neuronal axonal membrane protein NAP-22(gene name synonym)|uniprotkb:22 kDa neuronal tissue-enriched acidic protein(gene name synonym)|uniprotkb:Basp1(gene name)|psi-mi:Basp1(display_short)|uniprotkb:Nap22(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_081671.1|ensembl:ENSMUSG00000045763(gene)|ensembl:ENSMUST00000058845(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030426"(growth cone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|interpro:IPR008408(Brain acid soluble protein 1)|mint:Q91XV3|reactome:R-MMU-9035034	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:dwUwWfxMdUr+bki6HEHeaEibNOQ10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8BKX1	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:P61205	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-444797|uniprotkb:P16587|ensembl:ENSMUSP00000050689	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:arf3_mouse(display_long)|uniprotkb:Arf3(gene name)|psi-mi:Arf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_031504.1|refseq:XP_011243747.1|ensembl:ENSMUSG00000051853(gene)|ensembl:ENSMUST00000053183(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P61205|reactome:R-MMU-1660514|reactome:R-MMU-6807878|reactome:R-MMU-6811434	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:np09WjdbXRu9vgMbiXn9EA3ExqA10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8BIZ1	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-16724439|uniprotkb:E9Q644|uniprotkb:Q4KMR9|uniprotkb:Q8BJ47|uniprotkb:Q8BJ49	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ans1b_mouse(display_long)|uniprotkb:Amyloid-beta protein intracellular domain-associated protein 1(gene name synonym)|uniprotkb:E2A-PBX1-associated protein(gene name synonym)|uniprotkb:Anks1b(gene name)|psi-mi:Anks1b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	interpro:IPR041880|interpro:IPR041882|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900383"(regulation of synaptic plasticity by receptor localization to synapse)|mint:Q8BIZ1|refseq:NP_001170868.1|refseq:NP_001170869.1|refseq:NP_001333982.1|refseq:NP_001333983.1|refseq:NP_852063.1|interpro:IPR033636|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:xm2OG9kb/tmIo7e7c/qXBE4JeAY10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:G5E8K5	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-457262|uniprotkb:G5E8K4|uniprotkb:Q3TSJ8|uniprotkb:Q4U205|uniprotkb:Q4U206|uniprotkb:Q4U256|uniprotkb:Q4U260|uniprotkb:Q61307|uniprotkb:Q8CBN3|uniprotkb:Q8VC68|uniprotkb:O08866|uniprotkb:O08867|uniprotkb:Q61305|uniprotkb:Q61306|uniprotkb:Q61308|uniprotkb:Q61309|uniprotkb:Q61310|intact:EBI-2133089|ensembl:ENSMUSP00000090090|ensembl:ENSMUSP00000138326	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ank3_mouse(display_long)|uniprotkb:Ankyrin-G(gene name synonym)|uniprotkb:Ank3(gene name)|psi-mi:Ank3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_666117.2|refseq:XP_006513202.1|refseq:NP_033800.2|refseq:NP_733788.2|refseq:NP_733789.1|refseq:NP_733790.2|refseq:NP_733791.2|refseq:NP_733924.2|refseq:NP_733925.2|refseq:NP_733926.2|ensembl:ENSMUSG00000069601(gene)|ensembl:ENSMUST00000092434(transcript)|ensembl:ENSMUST00000182884(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010650"(positive regulation of cell communication by electrical coupling)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014704"(intercalated disc)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042383"(sarcolemma)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043194"(axon initial segment)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0050808"(synapse organization)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072660"(maintenance of protein location in plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0099612"(protein localization to axon)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1900827"(positive regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037971|interpro:IPR040745|mint:G5E8K5	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:sPFqnXYHQKlR6xjYE/VqOvNFxG010090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8C8R3	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-774322|intact:EBI-2133064|uniprotkb:Q6PCN2|uniprotkb:Q3TM62|uniprotkb:Q3V2X0|uniprotkb:Q80ZZ7|uniprotkb:Q8BNC1|uniprotkb:Q8C445|uniprotkb:Q8CCV0|intact:EBI-2255612|intact:EBI-8314005|intact:MINT-4115219	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:ank2_mouse(display_long)|uniprotkb:Brain ankyrin(gene name synonym)|uniprotkb:AnkB(gene name synonym)|uniprotkb:Ank2(gene name)|psi-mi:Ank2(display_short)|uniprotkb:Ankyrin-B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001029340.1|refseq:NP_848770.2|dip:DIP-58645N|mint:Q8C8R3|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0015031"(protein transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031430"(M band)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031672"(A band)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0036371"(protein localization to T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086066"(atrial cardiac muscle cell to AV node cell communication)|go:"GO:0086070"(SA node cell to atrial cardiac muscle cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901021"(positive regulation of calcium ion transmembrane transporter activity)|go:"GO:2001257"(regulation of cation channel activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:SkB13oxZVcKuMnI8r5ItFIq2pXQ10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q3UHD9	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-771911|uniprotkb:Q5DU45|ensembl:ENSMUSP00000043466	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:agap2_mouse(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Kiaa0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_001028435.1|refseq:NP_001287943.1|ensembl:ENSMUSG00000025422(gene)|ensembl:ENSMUST00000039259(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|go:"GO:0005768"(endosome)	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:yq2lQtfk+FPqgT++CxAx2CS69nE10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q4ACU6	uniprotkb:Q8CBW3	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2017)	pubmed:28671696|doi:10.1038/nn.4594|imex:IM-26285	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16726570|imex:IM-26285-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	go:"GO:0014069"(postsynaptic density)	-	-	figure legend:Table S1, Fig.1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/01/15	2021/02/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	rigid:IYXN37kjWq9nXsk93dczLzDm4J0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)